@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_32_1900: (2018-03-12 )
MGGGLSKSQLNVHYQGATEVESTYIVTKTDPNNNVVGAASATKPLSVVDAQWARNATEPGRDGVAVSAAAAAAAAPRKEEARGLGTAPARAGSALDGVGGNRGTNSATSAVDDNGSPIPIRNGGSHVGYICLSDIIGDKDSHSKYIKISSIGRGAYGEAYVVKRNPAYDAAARPMVEAQIQSNALANPTQPNGLYVAKIMDLRAMVSQDRQYAQTEIMCLAHTHHFAIIRYYEHYVLDSDDETVVIVTELADHGDLRRNLYNASAVRPFLEAGSQATTGGNAGTNDSRMLLTEREAGTYFVQLLLALHHISARRMIHRDIKSANVLLTSRGFLKLGDFGFSQKYESTVSSETIAGTFLGTPYYLSPEMWKGKRYGKKADVWAAGVVLYEMLMGGRRPFEAASLPELRMCVLEEEFVPPTGPPTSGAADVNSQEGGQPKFSNDMRELLVAIFQKAPEKRPSAEELLHKPVMQHYLYVFEKYVHSLISYDAAALAANPTMDRQGLYFADPGDQAMVLQGIAEGKAAIQQVTKRTISENASARFEGVVYKDNHNGVWKERYLLLDGATLTISLSKGKEAVGGGERSKRVLLSSIKSVSPCEVEDAHVRVVNAASPSDGYKPPYAFAIAMHSSNSIVFGVASAEELDHWMQALMRALQID
Atome Classification :
(31 SA)
------.........10........20........30........40........50........---60........70........80........90........100.......110.......120.......130.......140-----.......150.......160.......170.......180.......190.......200....------.-..210........220.-......230.......240.......250.......260.......270.......280.......290.......300.......310-..-.....320.....--..330.---........340....--...350.......360.......370----..-----.----......380.......390......----.400.......410-....--....420.......430.......440.......450.....--..-----460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
------MGGGLSK
S
Q
L
N
V
H
YQGATE
V
E
S
T
Y
I
V
TKTDPNN
N
V
V
GAASATK
P
L
S
V
V
D
A
Q
WARNATEP---GRD
G
V
A
V
S
A
A
A
A
AAAAP
R
K
E
E
ARGLGTAPARAGSALDGVGGNRGTNSATSAVDDNGSPIPIRNGGS
H
V
G
Y
I
C
L
S
D
IIGDKDSH-----
S
K
Y
I
K
I
S
SIGRGAYG
E
A
Y
V
V
KRNPAYD
A
A
AR
P
M
V
E
A
Q
IQSNALANPTQPN
G
L
Y
V
A
K
I
M
D
L
R
A
M
V
------
S
-
Q
D
R
Q
-
Y
A
Q
T
E
I
M
C
L
AHT-
H
H
F
A
I
I
R
Y
Y
E
H
YVLDSDD
E
T
V
V
I
V
TELAD
H
G
D
L
R
R
N
LY
N
A
S
A
V
R
P
F
L
EAGSQATTGGNAGTND
S
R
M
L
L
T
EREA
G
T
Y
F
V
Q
L
L
L
A
L
H
H
I
S
A
-
R
R
-
M
I
H
R
D
IKSA
N
V
L
L
--TSR--G---
F
L
K
LGDFGF
S
Q
K
Y
E
S--TVSSE
T
I
A
G
T
FLGTPYYLSPEMWK------GK-----R----YGKK
A
D
V
W
A
A
G
V
V
L
Y
E
M
L
MGGRRPF----EAAS
L
P
E
L
R
M
C
V
L
--
E
EEF--VPPTGPPTSGAADVNSQEGGQPK
F
S
N
D
M
R
E
L
L
V
A
I
F
Q
KAPEK--RP-----
S
A
E
E
L
L
H
K
P
V
M
Q
H
Y
L
Y
V
F
E
K
Y
V
H
S
L
I
S
Y
D
A
A
A
LAANPTMDRQG
L
Y
F
ADPGD
Q
A
M
V
L
Q
G
I
AE
G
K
A
A
I
Q
Q
V
T
K
R
T
I
SENASA
R
F
E
G
V
V
Y
KDNHNGV
W
K
E
R
Y
L
L
L
DG
A
T
L
T
I
S
LSKGKEAVGGG
E
R
S
K
R
V
L
L
S
S
IKSVSPCEVEDA
H
V
R
V
V
NAASPSDGYKP
P
Y
A
F
A
I
A
M
HSSN
S
I
V
F
GVA
S
A
E
E
L
D
H
W
M
Q
A
L
M
R
A
LQID
50
Fugue
67.45
20%
19
- C1 -
-
3C4Z
1
RK_BOVIN
A:
[31-533]
RD
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
C
E
A
L
R
E
S
L
D
L
G
F
E
G
M
C
L
E
Q
P
I
G
K
R
L
F
Q
Q
F
L
R
T
H
E
Q
H
G
P
A
L
Q
L
W
K
D
I
E
D
Y
D
T
A
D
D
A
L
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
E
P
Q
A
Q
L
F
C
S
F
L
D
A
E
T
V
A
R
A
R
A
G
G
L
F
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
P
M
G
E
-----
D
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
K
A
------------------------
T
G
K
L
Y
A
C
K
K
L
N
K
K
R
L
K
------
K
R
K
G
Y
Q
-
G
A
M
V
E
K
K
I
L
A
K
V
-
H
S
R
F
I
V
S
L
A
Y
A
F
E
---
T
K
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
V
D
E
D
N
P
G
F
Q
---------------------
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
-
R
N
-
I
I
Y
R
D
L
K
P
E
N
V
L
L
--
D
D
D
--
G
---
N
V
R
I
S
D
L
G
L
A
V
E
L
K
A
-----
G
Q
T
K
T
K
G
Y
A
G
T
P
G
F
M
A
P
E
L
L
L
------
G
E
-----
E
----
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
-
R
G
P
F
RARG
E
K
V
E
N
K
E
L
K
Q
R
V
L
--
E
Q
A
V
--
T
Y
P
------------------
D
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
--
R
L
-----
G
F
R
D
G
S
C
D
G
L
R
T
H
P
L
F
-----------------------------------
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
T
V
Y
A
K
N
G
A
F
S
G
V
A
F
E
K
A
D
T
E
F
F
Q
E
F
------
A
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
------
V
F
G
D
L
N
V
W
R
P
------------------------------------------------------------
1
PsiBlast_PDB
62.98
30%
-122
- C1 -
-
4APC
-
NEK1_HUMAN
A:
[22-277]
-----------------------------------------------------------------------------------------------------------------------------------------------------
S
M
-----
E
K
Y
V
R
L
Q
K
I
------
K
A
I
L
V
K
------------------------
S
T
E
D
G
R
Q
Y
V
I
K
E
I
N
I
S
R
M
S
------
S
-
K
E
R
E
-
E
S
R
R
E
V
A
V
L
A
N
M
-
K
H
P
N
I
V
Q
Y
R
E
S
F
---
E
E
N
G
S
L
Y
I
V
M
D
Y
C
E
G
G
D
L
F
K
R
I
--------------
N
A
Q
K
G
---------
V
L
F
Q
E
D
Q
I
L
D
W
F
V
Q
I
C
L
A
L
K
H
V
H
D
-
R
K
-
I
L
H
R
D
I
K
S
Q
N
I
F
L
--
T
K
D
--
G
---
T
V
Q
L
G
D
F
G
I
A
R
V
L
N
S
--
T
V
E
---
L
A
R
A
C
I
G
T
P
Y
Y
L
S
P
E
I
C
E
------
N
K
-----
P
----
Y
N
N
K
S
D
I
W
A
L
G
C
V
L
Y
E
-
L
C
T
L
K
H
A
F
----
E
A
G
S
M
K
N
L
V
L
K
I
I
--
S
G
S
F
-------
P
P
V
S
------------
L
H
Y
S
Y
D
L
R
S
L
V
S
Q
L
F
K
R
N
P
R
D
--
R
P
-----
S
V
N
S
I
L
E
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
61.98
30%
-121
- C1 -
-
4B9D
1
NEK1_HUMAN
A:
[22-277]
-----------------------------------------------------------------------------------------------------------------------------------------------------
S
M
-----
E
K
Y
V
R
L
Q
K
I
------
K
A
I
L
V
K
------------------------
S
T
E
D
G
R
Q
Y
V
I
K
E
I
N
I
S
R
M
S
------
S
-
K
E
R
E
-
E
S
R
R
E
V
A
V
L
A
N
M
-
K
H
P
N
I
V
Q
Y
R
E
S
F
---
E
E
N
G
S
L
Y
I
V
M
D
Y
C
E
G
G
D
L
F
K
R
I
--------------
N
A
Q
K
G
---------
V
L
F
Q
E
D
Q
I
L
D
W
F
V
Q
I
C
L
A
L
K
H
V
H
D
-
R
K
-
I
L
H
R
D
I
K
S
Q
N
I
F
L
--
T
K
D
--
G
---
T
V
Q
L
G
D
F
G
I
A
R
V
L
N
S
--
T
V
E
---
L
A
R
A
C
I
G
T
P
Y
Y
L
S
P
E
I
C
E
------
N
K
-----
P
----
Y
N
N
K
S
D
I
W
A
L
G
C
V
L
Y
E
-
L
C
T
L
K
H
A
F
----
E
A
G
S
M
K
N
L
V
L
K
I
I
--
S
G
S
F
-------
P
P
V
S
------------
L
H
Y
S
Y
D
L
R
S
L
V
S
Q
L
F
K
R
N
P
R
D
--
R
P
-----
S
V
N
S
I
L
E
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
59.45
29%
-67
- C1 -
-
5J5T
1
M4K3_HUMAN
A:
[3-269]
------------------------------------------------------------------------------------------------------------------------------------------------------
Q
-----
E
D
F
E
L
I
Q
R
I
G
S
G
T
Y
G
D
V
Y
K
A
R
N
------------------------
V
N
T
G
E
L
A
A
I
K
V
I
K
L
E
P
G
---------
E
D
F
A
-
V
V
Q
Q
E
I
I
M
M
K
D
C
-
K
H
P
N
I
V
A
Y
F
G
S
Y
L
---
R
R
D
K
L
W
I
C
M
E
F
C
G
G
G
S
L
Q
D
I
Y
H
V
T
G
-------------------------
P
L
S
E
L
Q
I
A
Y
V
S
R
E
T
L
Q
G
L
Y
Y
L
H
S
-
K
G
-
K
M
H
R
D
I
K
G
A
N
I
L
L
--
T
D
N
--
G
---
H
V
K
L
A
D
F
G
V
S
A
Q
I
T
A
--
T
I
---
A
---
A
F
I
G
T
P
Y
W
M
A
P
E
V
A
A
V
ER---
K
G
-----
G
----
Y
N
Q
L
C
D
L
W
A
V
G
I
T
A
I
E
L
A
-
E
L
Q
P
P
M
----
F
D
L
H
P
M
R
A
L
F
L
M
T
--
K
S
N
F
--
Q
P
P
K
-------------
L
K
D
K
M
K
W
S
N
S
F
H
H
F
V
K
M
A
L
T
K
N
P
K
K
--
R
P
-----
T
A
E
K
L
L
Q
H
P
F
V
T
Q
H
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
HHSearch
57.28
27%
-110
- C1 -
-
5K00
1
MELK_HUMAN
A:
[7-266]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
-----
K
Y
Y
E
L
H
E
T
I
G
T
G
--
A
K
V
K
L
A
C
H
------------------------
I
L
T
G
E
M
V
A
I
K
I
M
D
K
N
T
L
-------
G
-
S
D
L
P
-
R
I
K
T
E
I
E
A
L
K
N
L
-
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
---
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
-------------------------
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
-
Q
G
-
Y
A
H
R
D
L
K
P
E
N
L
L
F
--
D
E
Y
--
H
---
K
L
K
L
I
D
F
G
L
C
A
K
P
-----------------
S
L
A
Y
A
A
P
E
L
I
Q
------
G
K
-----
S
Y---
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
-
C
G
F
L
P
F
----
D
D
D
N
V
M
A
L
Y
K
K
I
M
--
R
G
K
Y
--------------------
D
V
P
K
W
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
--
R
I
-----
S
M
K
N
L
L
N
H
P
W
I
M
Q
D
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
Fugue
55.34
24%
7
- C1 -
-
4AW2
5
MRCKA_RAT
A:
[1-416]
--------------------------------------------------------------------------------
S
G
E
V
R
L
R
Q
L
E
Q
F
I
L
D
G
P
A
Q
T
N
G
Q
C
F
S
V
E
T
L
L
D
I
L
I
C
L
Y
D
E
C
N
N
S
---
P
L
R
R
E
K
N
I
L
E
Y
L
E
W
A
K
P
F
T
S
K
V
K
Q
M
RLHR
E
D
F
E
I
L
K
V
I
G
R
G
A
F
G
E
V
A
V
V
K
L
K
------------------------
N
A
D
K
V
F
A
M
K
I
L
N
K
W
E
M
L
------
K
-
R
A
E
T
A
C
F
R
E
E
R
D
V
L
V
N
G
-
D
S
K
W
I
T
T
L
H
Y
A
F
Q
---
D
D
N
N
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
----------------------
F
E
D
R
--
L
P
E
E
M
A
R
F
Y
L
A
E
M
V
I
A
I
D
S
V
H
Q
-
L
H
-
Y
V
H
R
D
I
K
P
D
N
I
L
M
--
D
M
N
--
G
---
H
I
R
L
A
D
F
G
S
C
L
K
L
M
E
DG
T
V
Q
S
S
V
A
----
V
G
T
P
D
Y
I
S
P
E
I
L
Q
------
A
M
E
GGKG
R
----
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
-
E
T
P
F
----
Y
A
E
S
L
V
E
T
Y
G
K
I
M
N
H
K
E
R
F
--
Q
F
P
T
Q
V
T
---------------
D
V
S
E
N
A
K
D
L
I
R
R
L
I
C
S
R
E
H
R
LG
Q
N
-----
G
I
E
D
F
K
K
H
P
F
F
S
G
I
D
W
------
D
N
I
R
N
C
E
A
P
Y
I
P
E
V
S
S
P
T
D
T
S
N
F
D
V
D
S
G
H
H
-
L
P
F
V
G
F
T
-------
Y
T
S
S
C
V
L
S
D
R
S
C
L
R
--------------------------------------------------------------------------------------------------------------------
27
HHSearch
55.27
29%
3
- C1 -
-
2Y7J
1
PHKG2_HUMAN
C:
[93-364]
------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-----
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
------------------------
R
A
T
G
H
E
F
A
V
K
I
M
E
V
T
A
E
R
LSPEQL
E
-
E
V
R
E
-
A
T
R
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
---
S
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
V
-------------------------
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
-
N
N
-
I
V
H
R
D
L
K
P
E
N
I
L
L
--
D
D
N
--
M
---
Q
I
R
L
S
D
F
G
F
S
C
H
L
E
P
--
G
----
E
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
CSMDET
H
P
-----
G
----
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
-
G
S
P
P
F
----
W
H
R
R
Q
I
L
M
L
R
M
I
M
--
E
G
Q
Y
--
Q
F
S
--------------
S
P
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
--
R
L
-----
T
A
E
Q
A
L
Q
H
P
F
F
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
HHSearch
54.50
28%
-109
- C1 -
-
4XBR
1
INKA1_HUMAN (first)
A:
[93-350]
------------------------------------------------------------------------------------------------------------------------------------------------------
R
-----
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
------------------------
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
Q
---------
Q
R
R
E
-
L
L
F
N
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
---
V
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
T
--------------------------
R
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
-
Q
G
-
V
I
H
R
D
I
K
S
D
S
I
L
L
--
T
H
D
--
G
---
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
--
E
V
---
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
------
R
L
-----
P
----
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
-
D
G
E
P
P
Y
----
F
N
E
P
P
L
K
A
M
K
M
I
R
--
D
N
-
L
---
P
P
R
-------------
L
K
N
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
--
R
A
-----
T
A
A
E
L
L
K
H
P
F
L
A
K
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
HHSearch
53.74
29%
-34
- C1 -
-
3V8S
1
ROCK1_HUMAN
D:
[68-340]
------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----
E
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
------------------------
K
S
T
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K-----
R
-
S
D
S
A
-
F
F
W
E
E
R
D
I
M
A
F
A
-
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
---
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
--------------------------
D
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
-
F
I
H
R
D
V
K
P
D
N
M
L
L
--
D
K
S
--
G
---
H
L
K
L
A
D
F
G
T
C
M
K
M
N
K
--
E
G
--
M
V
R
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
------
S
Q
-----
G
GDGY
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
-
V
G
D
T
P
F
----
Y
A
D
S
L
V
G
T
Y
S
K
I
M
--
N
H
K
N
--
S
L
T
--------------
F
P
D
D
N
D
I
S
K
E
A
K
N
L
I
C
A
F
L
T
D
R
E
V
R
LG
R
N
-----
G
V
E
E
I
K
R
H
L
F
F
K
N
D
Q
W
A
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
52.63
30%
-39
- C1 -
-
4WOT
1
ROCK2_HUMAN
B:
[68-341]
------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----
E
D
Y
D
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
------------------------
K
A
S
Q
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
-----
R
-
S
D
S
A
-
F
F
W
E
E
R
D
I
M
A
F
A
-
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
---
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
--------------------------
D
V
P
E
K
W
A
K
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
-
L
I
H
R
D
V
K
P
D
N
M
L
L
--
D
K
H
--
G
---
H
L
K
L
A
D
F
G
T
C
M
K
M
D
E
--
T
G
--
M
V
H
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
------
S
Q
-----
G
GDGF
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
-
G
D
T
P
F
----
Y
A
D
S
L
V
G
T
Y
S
K
I
M
--
D
H
K
N
--
S
L
C
--------------
F
P
E
D
A
E
I
S
K
H
A
K
N
L
I
C
A
F
L
T
D
R
E
V
R
LG
R
N
-----
G
V
E
E
I
R
Q
H
P
F
F
K
N
D
Q
W
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
52.16
29%
6
- C1 -
-
2Y7J
1
PHKG2_HUMAN
D:
[92-364]
-----------------------------------------------------------------------------------------------------------------------------------------------------
F
Y
-----
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
------------------------
R
A
T
G
H
E
F
A
V
K
I
M
E
V
---
R
LSPEQL
E
-
E
V
R
E
-
A
T
R
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
---
S
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
V
-------------------------
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
-
N
N
-
I
V
H
R
D
L
K
P
E
N
I
L
L
--
D
D
N
--
M
---
Q
I
R
L
S
D
F
G
F
S
C
H
L
E
P
--
G
----
E
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
CSMDET
H
P
-----
G
----
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
-
G
S
P
P
F
----
W
H
R
R
Q
I
L
M
L
R
M
I
M
--
E
G
Q
Y
--
Q
F
S
--------------
S
P
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
--
R
L
-----
T
A
E
Q
A
L
Q
H
P
F
F
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
49.23
25%
-61
- C1 -
-
2BDW
-
KCC2D_CAEEL
A:
[10-275]
------------------------------------------------------------------------------------------------------------------------------------------------------
S
-----
D
N
Y
D
V
K
E
E
L
G
K
G
A
F
S
V
V
R
R
C
V
H
------------------------
K
T
T
G
L
E
F
A
A
K
I
I
N
T
K
K
L
S
------
A
-
R
D
F
Q
-
K
L
E
R
E
A
R
I
C
R
K
L
-
Q
H
P
N
I
V
R
L
H
D
S
I
Q
---
E
E
S
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
-------------------------
F
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
I
A
Y
C
H
S
-
N
G
-
I
V
H
R
N
L
K
P
E
N
L
L
L
--
A
S
K
--
A
KG
A
A
V
K
L
A
D
F
G
L
A
I
E
V
N
D
--
S
----
E
A
W
H
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
K
------
K
D
-----
P
----
Y
S
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
-
V
G
Y
P
P
F
----
W
D
E
D
Q
H
R
L
Y
A
Q
I
K
--
A
G
A
Y
--
D
Y
P
--------------
S
P
E
W
D
T
V
T
P
E
A
K
S
L
I
D
S
M
L
T
V
N
P
K
K
--
R
I
-----
T
A
D
Q
A
L
K
V
P
W
I
C
N
R
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
48.35
30%
-89
- C1 -
-
2W5A
5
NEK2_HUMAN
A:
[33-271]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
V
W
K
E
L
D
Y
G
S
M
T
------
E
-
A
E
K
Q
-
M
L
V
S
E
V
N
L
L
R
E
L
-
K
H
P
N
I
V
R
Y
Y
D
R
-
I
I
D
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
------
A
S
V
I
--------------
T
K
G
T
K
E
-
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
-
R
S
--
L
H
R
D
L
K
P
A
N
V
F
L
--
D
G
K
--
Q
---
N
V
K
L
G
D
F
G
L
A
R
I
L
-----
T
S
---
F
A
K
T
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
------
R
M
----------
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
-
L
C
A
L
M
P
P
F
----
T
A
F
S
Q
K
E
L
A
G
K
I
R
--
E
G
K
F
RR
I
P
-------------------
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
--
R
P
-----
S
V
E
E
I
L
E
N
P
L
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
48.34
30%
-93
- C1 -
-
2XKF
1
NEK2_HUMAN
A:
[33-271]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
V
W
K
E
L
D
Y
G
S
M
T
------
E
-
A
E
K
Q
-
M
L
V
S
E
V
N
L
L
R
E
L
-
K
H
P
N
I
V
R
Y
Y
D
R
-
I
I
D
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
------
A
S
V
I
--------------
T
K
G
T
K
E
-
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
-
R
S
----
R
D
L
K
P
A
N
V
F
L
--
D
G
K
--
Q
---
N
V
K
L
G
D
F
--------------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
------
R
------
S
----
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
-
L
C
A
L
M
P
P
F
----
T
A
F
S
Q
K
E
L
A
G
K
I
R
--
E
G
K
F
RR
I
P
-------------------
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
--
R
P
-----
S
V
E
E
I
L
E
N
P
L
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
48.27
25%
-57
- C1 -
-
2X4F
4
MYLK4_HUMAN
A:
[89-350]
------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
V
S
K
T
E
I
L
G
-----
Q
V
H
K
C
E
E
------------------------
T
A
T
G
L
K
L
A
A
K
I
I
K
T
R
G
M
---------
K
D
K
E
-
E
V
K
N
E
I
S
V
M
N
Q
L
-
D
H
A
N
L
I
Q
L
Y
D
A
F
E
---
S
K
N
D
I
V
L
V
M
E
Y
V
D
G
G
E
L
F
D
R
I
I
D
E
S
------------------------
Y
N
L
T
E
L
D
T
I
L
F
M
K
Q
I
C
E
G
I
R
H
M
H
Q
-
M
Y
-
I
L
H
L
D
L
K
P
E
N
I
L
C
VN
R
D
A
--
K
---
Q
I
K
I
I
D
F
G
L
A
R
R
Y
K
P
--
R
E
----
K
L
K
V
N
F
G
T
P
E
F
L
A
P
E
V
V
N
------
Y
D
-----
F
----
V
S
F
P
T
D
M
W
S
V
G
V
I
A
Y
M
L
L
-
S
G
L
S
P
F
----
L
G
D
N
D
A
E
T
L
N
N
I
L
--
A
C
R
W
--
D
L
E
--------------
D
E
E
F
Q
D
I
S
E
E
A
K
E
F
I
S
K
L
L
I
K
E
K
S
W
--
R
I
-----
S
A
S
E
A
L
K
H
P
W
L
S
D
H
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
48.18
32%
-139
- C1 -
-
2WQN
1
NEK7_HUMAN
A:
[59-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
V
A
L
K
K
V
Q
I
F
D
L
--
M
D
------
A
-
K
A
R
A
-
D
C
I
K
E
I
D
L
L
K
Q
L
-
N
H
P
N
V
I
K
Y
Y
A
S
F
I
---
E
D
N
E
L
N
I
V
L
E
L
A
D
A
G
D
L
S
R
------
M
I
K
H
F
---------------
K
K
Q
K
R
L
I
P
E
R
T
V
W
K
Y
F
V
Q
L
C
S
A
L
E
H
M
H
S
-
R
R
-
V
M
H
R
D
I
K
P
A
N
V
F
I
--
T
A
T
--
G
---
V
V
K
L
G
D
L
-----------------------
T
P
Y
Y
M
S
P
E
R
I
H
------
E
N
-----
G
----
Y
N
F
K
S
D
I
W
S
L
G
C
L
L
Y
E
M
-
A
A
L
Q
S
P
F
----
Y
---
M
N
L
Y
S
L
C
K
K
--
I
E
Q
C
--
D
Y
P
P
L
P
S
D
H
--------------
Y
S
E
E
L
R
Q
L
V
N
M
C
I
N
P
D
P
E
K
--
R
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
Fugue
48.13
19%
-32
- C1 -
-
1TKI
-
TITIN_HUMAN
A:
[18-338]
---------------------------------------------------------------------------------------------------------------------------------------------------
K
E
L
Y
-----
E
K
Y
M
I
A
E
D
L
G
R
G
E
F
G
I
V
H
R
C
V
E
T
S
------------------------
S
K
K
T
Y
M
A
K
F
V
K
V
K
---------
G
-
T
D
Q
V
-
L
V
K
K
E
I
S
I
L
N
I
A
-
R
H
R
N
I
L
H
L
H
E
S
F
E
S
M
E
---
E
L
V
M
I
F
E
F
I
S
G
L
D
I
F
E
R
I
------------------------
N
T
S
A
F
E
L
N
E
R
E
I
V
S
Y
V
H
Q
V
C
E
A
L
Q
F
L
H
S
-
H
N
-
I
G
H
F
D
I
R
P
E
N
I
I
Y
--
Q
T
R
RS
S
---
T
I
K
I
I
E
F
G
Q
A
R
Q
------
L
K
P
G
D
N
F
R
L
L
F
T
A
P
E
Y
Y
A
P
E
V
H
Q
------
H
D
-----
V
----
V
S
T
A
T
D
M
W
S
L
G
T
L
V
Y
-
V
L
L
S
G
I
N
P
F
----
L
A
E
T
N
Q
Q
I
I
E
N
I
M
--
N
A
E
Y
----------------
T
F
D
E
E
A
F
K
E
I
S
I
E
A
M
D
F
V
D
R
L
L
V
K
E
R
K
S
--
R
M
-----
T
A
S
E
A
L
Q
H
P
W
L
K
Q
K
I
E
R
V
S
T
K
V
I
R
T
L
K
H
R
R
Y
Y
H
T
L
I
K
K
D
L
N
M
V
V
S
A
A
R
I
S
C
G
G
A
I
R
S
Q
K
G
V
S
V
A
K
V
K
V
A
S
I
------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
47.85
32%
-140
- C1 -
-
5DE2
-
NEK7_HUMAN
A:
[59-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
V
A
L
K
K
V
Q
I
F
D
L
--
M
D
------
A
-
K
A
R
A
-
D
C
I
K
E
I
D
L
L
K
Q
L
-
N
H
P
N
V
I
K
F
Y
A
S
F
I
---
E
D
N
E
L
N
I
V
L
E
L
A
D
A
G
D
L
S
R
------
M
I
K
H
F
---------------
K
K
Q
K
R
L
I
P
E
R
T
V
W
K
Y
F
V
Q
L
C
S
A
L
E
H
M
H
S
-
R
R
-
V
M
H
R
D
I
K
P
A
N
V
F
I
--
T
A
T
--
G
---
V
V
K
L
G
D
L
G
L
-------------------
V
G
T
P
Y
Y
M
S
P
E
R
I
H
------
E
N
-----
G
----
Y
N
F
K
S
D
I
W
S
L
G
C
L
L
Y
E
M
-
A
A
L
Q
S
P
F
----
Y
G
D
K
M
N
L
Y
S
L
C
K
K
--
I
E
Q
C
--
D
Y
P
P
L
P
S
D
H
--------------
Y
S
E
E
L
R
Q
L
V
N
M
C
I
N
P
D
P
E
K
--
R
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
47.75
30%
-78
- C1 -
-
2XNN
6
NEK2_HUMAN
A:
[33-271]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
V
W
K
E
L
D
Y
G
S
M
T
------
E
-
A
E
K
Q
-
M
L
V
S
E
V
N
L
L
R
E
L
-
K
H
P
N
I
V
R
Y
Y
D
R
-
I
I
D
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
------
A
S
V
I
--------------
T
K
G
T
K
E
-
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
-
R
S
----
R
D
L
K
P
A
N
V
F
L
--
D
G
K
--
Q
---
N
V
K
L
G
D
F
G
-------------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
------
R
-----------
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
-
L
C
A
L
M
P
P
F
----
T
A
F
S
Q
K
E
L
A
G
K
I
R
--
E
G
K
F
RR
I
P
-------------------
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
--
R
P
-----
S
V
E
E
I
L
E
N
P
L
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
47.29
26%
-21
- C1 -
-
4GV1
5
AKT1_HUMAN
A:
[7-277]
------------------------------------------------------------------------------------------------------------------------------------------------------
M
-----
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
------------------------
K
A
T
G
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
-----
K
-
D
E
V
A
-
H
T
L
T
E
N
R
V
L
Q
N
S
-
R
H
P
F
L
T
A
L
K
Y
S
F
Q
---
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
-------------------------
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
-
V
V
Y
R
D
L
K
L
E
N
L
M
L
--
D
K
D
--
G
---
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
--
D
G
---
A
T
M
K
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
------
D
N
-----
D
----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
-
C
G
R
L
P
F
----
Y
N
Q
D
H
E
K
L
F
E
L
I
L
--
M
E
E
I
--------------------
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
GGGS
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
47.25
30%
-88
- C1 -
-
2XK6
1
NEK2_HUMAN
A:
[33-271]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
V
W
K
E
L
D
Y
G
S
M
T
------
E
-
A
E
K
Q
-
M
L
V
S
E
V
N
L
L
R
E
L
-
K
H
P
N
I
V
R
Y
Y
D
R
-
I
I
D
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
------
A
S
V
I
--------------
T
K
G
T
K
E
-
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
-
R
S
----
R
D
L
K
P
A
N
V
F
L
--
D
G
K
--
Q
---
N
V
K
L
G
D
----------------------
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
------
R
------------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
-
L
C
A
L
M
P
P
F
----
T
A
F
S
Q
K
E
L
A
G
K
I
R
--
E
G
K
F
RR
I
P
-------------------
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
--
R
P
-----
S
V
E
E
I
L
E
N
P
L
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
47.04
30%
-86
- C1 -
-
2XK3
1
NEK2_HUMAN
A:
[33-271]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
V
W
K
E
L
D
Y
G
S
M
T
------
E
-
A
E
K
Q
-
M
L
V
S
E
V
N
L
L
R
E
L
-
K
H
P
N
I
V
R
Y
Y
D
R
-
I
I
D
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
------
A
S
V
I
--------------
T
K
G
T
K
E
-
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
-
R
S
----
R
D
L
K
P
A
N
V
F
L
--
D
G
K
--
Q
---
N
V
K
L
G
D
F
G
--------------------
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
------
R
------------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
-
L
C
A
L
M
P
P
F
----
T
A
F
S
Q
K
E
L
A
G
K
I
R
--
E
G
K
F
RR
I
P
-------------------
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
--
R
P
-----
S
V
E
E
I
L
E
N
P
L
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
46.75
30%
-86
- C1 -
-
2XK8
1
NEK2_HUMAN
A:
[33-271]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
V
W
K
E
L
D
Y
G
S
M
T
------
E
-
A
E
K
Q
-
M
L
V
S
E
V
N
L
L
R
E
L
-
K
H
P
N
I
V
R
Y
Y
D
R
-
I
I
D
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
------
A
S
V
I
--------------
T
K
G
T
K
E
-
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
-
R
S
----
R
D
L
K
P
A
N
V
F
L
--
D
G
K
--
Q
---
N
V
K
L
G
D
F
--------------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
-------------------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
-
L
C
A
L
M
P
P
F
----
T
A
F
S
Q
K
E
L
A
G
K
I
R
--
E
G
K
F
RR
I
P
-------------------
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
--
R
P
-----
S
V
E
E
I
L
E
N
P
L
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
45.56
30%
-90
- C1 -
-
2XNP
6
NEK2_HUMAN
A:
[33-271]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
V
W
K
E
L
D
Y
G
S
M
T
------
E
-
A
E
K
Q
-
M
L
V
S
E
V
N
L
L
R
E
L
-
K
H
P
N
I
V
R
Y
Y
D
R
-
I
I
D
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
------
A
S
V
I
--------------
T
K
G
T
K
E
-
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
-
R
S
---
H
R
D
L
K
P
A
N
V
F
L
--
D
G
K
--
Q
---
N
V
K
L
G
D
F
G
L
------------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
------
R
------------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
-
L
C
A
L
M
P
P
F
----
T
A
F
S
Q
K
E
L
A
G
K
I
R
--
E
G
K
F
RR
I
P
-------------------
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
--
R
P
-----
S
V
E
E
I
L
E
N
P
L
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
44.40
30%
-86
- C1 -
-
2XKC
1
NEK2_HUMAN
A:
[33-271]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
V
W
K
E
L
D
Y
G
S
M
T
------
E
-
A
E
K
Q
-
M
L
V
S
E
V
N
L
L
R
E
L
-
K
H
P
N
I
V
R
Y
Y
D
R
-
I
I
D
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
------
A
S
V
I
--------------
T
K
G
T
K
E
-
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
-
R
S
------
L
K
P
A
N
V
F
L
--
D
G
K
--
Q
---
N
V
K
L
G
D
-----------------------
G
T
P
Y
Y
M
S
P
E
Q
M
N
------
R
------------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
-
L
C
A
L
M
P
P
F
----
T
A
F
S
Q
K
E
L
A
G
K
I
R
--
E
G
K
F
RR
I
P
-------------------
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
--
R
P
-----
S
V
E
E
I
L
E
N
P
L
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
44.39
30%
-85
- C1 -
-
2XK7
1
NEK2_HUMAN
A:
[33-271]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
V
W
K
E
L
D
Y
G
S
M
T
------
E
-
A
E
K
Q
-
M
L
V
S
E
V
N
L
L
R
E
L
-
K
H
P
N
I
V
R
Y
Y
D
R
-
I
I
D
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
------
A
S
V
I
--------------
T
K
G
T
K
E
-
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
-
R
S
----
R
D
L
K
P
A
N
V
F
L
--
D
G
K
--
Q
---
N
V
K
L
G
D
F
---------------------
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
-------------------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
-
L
C
A
L
M
P
P
F
----
T
A
F
S
Q
K
E
L
A
G
K
I
R
--
E
G
K
F
RR
I
P
-------------------
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
--
R
P
-----
S
V
E
E
I
L
E
N
P
L
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
44.38
30%
-85
- C1 -
-
2XK4
1
NEK2_HUMAN
A:
[33-271]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
V
W
K
E
L
D
Y
G
S
M
T
------
E
-
A
E
K
Q
-
M
L
V
S
E
V
N
L
L
R
E
L
-
K
H
P
N
I
V
R
Y
Y
D
R
-
I
I
D
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
------
A
S
V
I
--------------
T
K
G
T
K
E
-
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
-
R
S
----
R
D
L
K
P
A
N
V
F
L
--
D
G
K
--
Q
---
N
V
K
L
G
D
F
G
L
------------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
------
R
M
-----------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
-
L
C
A
L
M
P
P
F
----
T
A
F
S
Q
K
E
L
A
G
K
I
R
--
E
G
K
F
RR
I
P
-------------------
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
--
R
P
-----
S
V
E
E
I
L
E
N
P
L
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
43.46
30%
-86
- C1 -
-
2XNO
13
NEK2_HUMAN
A:
[33-271]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
V
W
K
E
L
D
Y
G
S
M
T
------
E
-
A
E
K
Q
-
M
L
V
S
E
V
N
L
L
R
E
L
-
K
H
P
N
I
V
R
Y
Y
D
R
-
I
I
D
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
------
A
S
V
I
--------------
T
K
G
T
K
E
-
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
-
R
S
----
R
D
L
K
P
A
N
V
F
L
--
D
G
K
--
Q
---
N
V
K
L
G
D
F
--------------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
------
R
------------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
-
L
C
A
L
M
P
P
F
----
T
A
F
S
Q
K
E
L
A
G
K
I
R
--
E
G
K
F
RR
I
P
-------------------
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
--
R
P
-----
S
V
E
E
I
L
E
N
P
L
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
43.46
30%
-91
- C1 -
-
2WQO
1
NEK2_HUMAN
A:
[33-271]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
V
W
K
E
L
D
Y
G
S
M
T
------
E
-
A
E
K
Q
-
M
L
V
S
E
V
N
L
L
R
E
L
-
K
H
P
N
I
V
R
Y
Y
D
R
-
I
I
D
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
------
A
S
V
I
--------------
T
K
G
T
K
E
-
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
-
R
-------
L
K
P
A
N
V
F
L
--
D
G
K
--
Q
---
N
V
K
L
G
D
-----------------------
G
T
P
Y
Y
M
S
P
E
Q
M
N
------
R
------------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
-
L
C
A
L
M
P
P
F
----
T
A
F
S
Q
K
E
L
A
G
K
I
R
--
E
G
K
F
RR
I
P
-------------------
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
--
R
P
-----
S
V
E
E
I
L
E
N
P
L
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
42.92
30%
-68
- C1 -
-
2XKD
1
NEK2_HUMAN
A:
[33-271]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
V
W
K
E
L
D
Y
G
S
M
T
------
E
-
A
E
K
Q
-
M
L
V
S
E
V
N
L
L
R
E
L
-
K
H
P
N
I
V
R
Y
Y
D
R
-
I
I
D
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
------
A
S
V
I
--------------
T
K
G
T
K
E
-
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
-
R
S
D-----
L
K
P
A
N
V
F
L
--
D
G
K
--
Q
---
N
V
K
L
G
D
F
-------------------
T
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
------
R
M
-----
S
----
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
-
L
C
A
L
M
P
P
F
----
T
A
F
S
Q
K
E
L
A
G
K
I
R
--
E
G
K
F
RR
I
P
-------------------
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
--
R
P
-----
S
V
E
E
I
L
E
N
P
L
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
41.32
30%
-66
- C1 -
-
2XKE
1
NEK2_HUMAN
A:
[33-271]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
V
W
K
E
L
D
Y
G
S
M
T
------
E
-
A
E
K
Q
-
M
L
V
S
E
V
N
L
L
R
E
L
-
K
H
P
N
I
V
R
Y
Y
D
R
-
I
I
D
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
------
A
S
V
I
--------------
T
K
G
T
K
E
-
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
-
R
S
D-----
L
K
P
A
N
V
F
L
--
D
G
K
--
Q
---
N
V
K
L
G
D
F
-----------------------
T
P
Y
Y
M
S
P
E
Q
M
N
-------------------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
-
L
C
A
L
M
P
P
F
----
T
A
F
S
Q
K
E
L
A
G
K
I
R
--
E
G
K
F
RR
I
P
-------------------
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
--
R
P
-----
S
V
E
E
I
L
E
N
P
L
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------