@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_32_3450: (2018-03-12 )
MEAYEILGILGEGTYGVVVKARSRVTGKLVAIKRFKQTEQDEHVRKTSSREVRMLQLLQHPNVIRLEDVFRREGKLYLVFEFIDQTILQLLESTTRGLHRRELRRYTYQLLRGIEFCHNHNVIHRDVKPENVLIDESGLLKLCDFGFARQTSAKGKYTDYVATRWYRAPELLVGDVAYGKPVDVWALGCMFAELSDGQPLFPGESDLDQLCLIMQTCGPVPQRLVFIFMHNPLYNGISFPHTDILYTLKERYHRESNDWLEFLSSCLHTDPAQRLTCTELMELPYFTRDGFRDRYEAELRAATGLPQLRSTPTTSAPSTQRRAPDQAVALGGDLKADTVVSPHERRSSEIISPKLQGEQPPTVKNSSSDTHISKTALKPAAHDANAGKGKGAGAPTFTLTSPHKAASEHPVQLPMILNSNSERAVAAALTDYLNQMPASSSAVVSTPLQATPAEVAGGFTNADLLSRSCGAVPPPQTSQITNPSTTRDKNRKRNVGLAETELHRPSSASISDDTEYAATIDSSKGEPAKHISDHPRASATLPPNGVLGSGGSHEPTREGEKTNASPPLPSHGVAESSMRVLLTTAAPGKDDGETAVLSHRPLKPASADKAAATAATAFSSPTLAATHGAPLAECLQGLPALSLHLPRHLQQERQTPAAEQPQSHTPLSAETSISSFHVCRRNPLAAASTENDDVSRGKANIEPAGSSVANPRRGLSNSSVSTAASETKKRKSARHKRDTSRLHDQAVGPVSGSASRRSVPGNASDVVAYRAGFASVVNSLKSTVSQSLSYILGQQQRQPLLSPDSRGVHAADPHLHGVGAGPSVPDSTHNRNADAAGPQLRKERRSKPLAASTHALQGSDQRHRQQSQPRLDGPLHPDGGASQRATATLMALSALRNVSLPPPTKSAGDADKSSYGHHTRSHTNNNGGETVSPVVGGDGNGTQTCIASRARRPIAVCAVHGNNRDSDELISTRRVQKKNAVATHGRTGNGAVGPISCTDSSTTSSYQATSIMYGAPYHPFTRASKMDGEVGGAPQRQTLRRPKKKIADSRGSGIANITSSIGPRHSLARARQIQHQPQLAKEDGGSGDGKTPQFNAAAAASPYTSS
Atome Classification :
(23 SA)
.........10........20........30........40........50........60........70........80........90.-.......100.......110.......120.......130.......140.......-150....-...160.......170.......180.......190.......200......-.-210.......220.......230........240-----.....-...250......-.260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100...
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
E
A
Y
E
I
L
G
I
LGEG
T
Y
G
V
V
V
K
ARSRVTG
K
L
V
A
I
K
R
F
KQT
E
Q
D
E
H
V
R
KTSS
R
E
V
R
M
L
Q
L
LQHP
N
V
I
R
L
E
D
V
F
R
REG
K
L
Y
L
V
F
E
F
I
D
Q
T
I
L
Q
L
L
E
-
S
T
T
R
G
L
H
R
R
E
L
R
R
Y
T
Y
Q
L
L
R
G
I
E
F
C
HNHNVIHRDVKPE
N
V
L
IDESG
L
L
K
L
CDFGFAR-QTSAKGK-
Y
T
D
Y
V
A
T
R
WYRA
P
E
L
L
V
GDVAYGK
P
V
D
V
W
A
L
G
C
M
F
A
ELSDGQPLFPGES
D
L
D
-
Q
-
L
C
L
I
M
Q
TCGP
V
P
Q
R
L
V
F
I
F
MHN-PLYNGISFP
H
------
T
D
I
L
Y
-
T
L
K
E
R
YHRES
N
D
-
W
L
E
F
L
S
S
C
LHTDPAQRL
T
C
T
E
L
M
ELPYFTRDGF
R
D
R
Y
E
A
E
L
R
AATGLPQLRSTPTTSAPSTQRRAPDQ
A
V
ALGGDLKADTVVSPHERRSSEIISPKLQGEQPPTVKNSSSDTHI
S
K
TALKPAAHDANAGKGKGAGA
P
T
F
T
LTSPHKAASEHP
V
Q
L
P
M
I
LNSNS
E
R
A
V
A
A
A
L
T
D
Y
L
N
QMPASSS
A
V
VSTPLQA
T
P
A
E
VAGGFT
N
A
D
L
L
S
RSCGAVPPPQTSQITNPSTTRDKNRKRNVGLA
E
T
ELHRPSSASISDDT
E
Y
A
A
TIDSSKGEP
A
K
HISDHPRASATLPPNGVLGSGGSHEPTREGEKTNASPPLPSHGVAESS
M
R
V
L
L
T
TAAPGKDDG
E
T
A
VLSHRPLKPASADK
A
A
A
T
A
ATAFSSP
T
L
AATHGA
P
L
A
E
C
L
Q
GLP
A
L
S
L
H
L
P
R
H
L
Q
Q
E
RQTPAAEQPQSHTPLSAETSI
S
S
F
H
V
CRRNPLAAASTENDDVSRGKANIEPAGSSVANPRRGLSNSSVS
T
A
A
S
E
T
K
K
R
K
S
ARHKR
D
T
S
R
L
H
DQAVGPVSGSASRRSVPGN
A
S
D
V
V
A
Y
R
A
G
F
A
S
V
V
N
S
L
K
S
T
V
S
Q
S
L
S
Y
I
L
G
Q
Q
QRQPLLSPDSRGVHAADPHLHGVGAGPSVPDSTHNRNADAA
G
P
Q
L
R
K
E
RRSKPLAASTHALQGS
D
Q
R
H
R
Q
QSQPRLDGPLHPDGGAS
Q
R
A
T
A
T
L
M
A
L
S
A
L
RNVSLPPPTKSAGDADKSSYGHHTRSHTNNNGG
E
T
VSPVVGGDGN
G
T
Q
T
C
I
A
S
RARR
P
I
A
V
C
A
VHGNNR
D
S
D
E
L
I
S
T
R
R
V
QKKNAVATHGRTGNGAVG
P
I
SCTDSSTTSS
Y
Q
A
T
S
I
M
YGAPYHPFTRASKMDGEVGGA
P
Q
R
Q
T
L
R
R
P
K
K
K
IADSRGS
G
I
A
N
I
T
S
SIGP
R
H
S
L
A
R
A
R
Q
I
QHQPQLAKEDGGSGDGKTPQFNAAAAASPYTSS
1
PsiBlast_PDB
94.17
48%
-154
- C1 -
-
4AAA
7
CDKL2_HUMAN
A:
[24-324]
M
E
K
Y
E
N
L
G
L
V
G
E
G
S
Y
G
M
V
M
K
C
R
N
K
D
T
G
R
I
V
A
I
K
K
F
L
E
S
D
D
D
K
M
V
K
K
I
A
M
R
E
I
K
L
L
K
Q
L
R
H
E
N
L
V
N
L
L
E
V
C
K
K
K
K
R
W
Y
L
V
F
E
F
V
D
H
T
I
L
D
D
L
E
-
L
F
P
N
G
L
D
Y
Q
V
V
Q
K
Y
L
F
Q
I
I
N
G
I
G
F
C
H
S
H
N
I
I
H
R
D
I
K
P
E
N
I
L
V
S
Q
S
G
V
V
K
L
C
D
F
G
F
A
-------------
E
V
A
T
R
W
Y
R
A
P
E
L
L
V
G
D
V
K
Y
G
K
A
V
D
V
W
A
I
G
C
L
V
T
E
M
F
M
G
E
P
L
F
P
G
D
S
D
I
D
-
Q
-
L
Y
H
I
M
M
C
L
G
N
L
I
P
R
H
Q
E
L
F
N
K
N
-
P
V
F
A
G
V
R
L
P
E
------
I
K
E
R
E
-
P
L
E
R
R
Y
P
K
L
S
E
V
-
V
I
D
L
A
K
K
C
L
H
I
D
P
D
K
R
P
F
C
A
E
L
L
H
H
D
F
F
Q
M
D
G
F
A
E
R
F
S
Q
E
L
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
93.02
49%
-157
- C1 -
-
4AAA
7
CDKL2_HUMAN
A:
[24-318]
M
E
K
Y
E
N
L
G
L
V
G
E
G
S
Y
G
M
V
M
K
C
R
N
K
D
T
G
R
I
V
A
I
K
K
F
L
E
S
D
D
D
K
M
V
K
K
I
A
M
R
E
I
K
L
L
K
Q
L
R
H
E
N
L
V
N
L
L
E
V
C
K
K
K
K
R
W
Y
L
V
F
E
F
V
D
H
T
I
L
D
D
L
E
-
L
F
P
N
G
L
D
Y
Q
V
V
Q
K
Y
L
F
Q
I
I
N
G
I
G
F
C
H
S
H
N
I
I
H
R
D
I
K
P
E
N
I
L
V
S
Q
S
G
V
V
K
L
C
D
F
G
F
A
-------------
E
V
A
T
R
W
Y
R
A
P
E
L
L
V
G
D
V
K
Y
G
K
A
V
D
V
W
A
I
G
C
L
V
T
E
M
F
M
G
E
P
L
F
P
G
D
S
D
I
D
-
Q
-
L
Y
H
I
M
M
C
L
G
N
L
I
P
R
H
Q
E
L
F
N
K
N
-
P
V
F
A
G
V
R
L
P
E
------
I
K
E
R
E
-
P
L
E
R
R
Y
P
K
L
S
E
V
-
V
I
D
L
A
K
K
C
L
H
I
D
P
D
K
R
P
F
C
A
E
L
L
H
H
D
F
F
Q
M
D
G
F
A
E
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
HHSearch
88.67
49%
-132
- C1 -
-
4AGU
1
CDKL1_HUMAN
A:
[3-292]
-
E
K
Y
E
K
I
G
K
I
G
E
G
S
Y
G
V
V
F
K
C
R
N
R
D
T
G
Q
I
V
A
I
K
K
F
L
E
S
E
D
-
P
V
I
K
K
I
A
L
R
E
I
R
M
L
K
Q
L
K
H
P
N
L
V
N
L
L
E
V
F
R
R
K
R
R
L
H
L
V
F
E
Y
C
D
H
T
V
L
H
E
L
D
-
R
Y
Q
R
G
V
P
E
H
L
V
K
S
I
T
W
Q
T
L
Q
A
V
N
F
C
H
K
H
N
C
I
H
R
D
V
K
P
E
N
I
L
I
T
K
H
S
V
I
K
L
C
D
F
G
F
A
R
-
L
L
T
------------
R
W
Y
R
S
P
E
L
L
V
G
D
T
Q
Y
G
P
P
V
D
V
W
A
I
G
C
V
F
A
E
L
L
S
G
V
P
L
W
P
G
K
S
D
V
D
-
Q
-
L
Y
L
I
R
K
T
L
G
D
L
I
P
R
H
Q
Q
V
F
S
T
N
-
Q
Y
F
S
G
V
K
I
P
D
------
P
E
D
M
E
-
P
L
E
L
K
F
P
N
I
S
Y
P
-
A
L
G
L
L
K
G
C
L
H
M
D
P
T
E
R
L
T
C
E
Q
L
L
H
H
P
Y
F
E
N
I
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
88.34
48%
-92
- C1 -
-
4BBM
3
CDKL2_HUMAN
A:
[24-324]
M
E
K
Y
E
N
L
G
L
V
G
--
S
Y
G
M
V
M
K
C
R
N
K
D
T
G
R
I
V
A
I
K
K
F
L
E
S
D
D
D
K
M
V
K
K
I
A
M
R
E
I
K
L
L
K
Q
L
R
H
E
N
L
V
N
L
L
E
V
C
K
K
K
K
R
W
Y
L
V
F
E
F
V
D
H
T
I
L
D
D
L
E
-
L
F
P
N
G
L
D
Y
Q
V
V
Q
K
Y
L
F
Q
I
I
N
G
I
G
F
C
H
S
H
N
I
I
H
R
D
I
K
P
E
N
I
L
V
S
Q
S
G
V
V
K
L
C
D
F
G
F
A
R
-
T
L
A
A
P
G
E
V
Y
D
D
E
V
A
T
R
W
Y
R
A
P
E
L
L
V
G
D
V
K
Y
G
K
A
V
D
V
W
A
I
G
C
L
V
T
E
M
F
M
G
E
P
L
F
P
G
D
S
D
I
D
-
Q
-
L
Y
H
I
M
M
C
L
G
N
L
I
P
R
H
Q
E
L
F
N
K
N
-
P
V
F
A
G
V
R
L
P
E
------
I
K
E
R
E
-
P
L
E
R
R
Y
P
K
L
S
E
V
-
V
I
D
L
A
K
K
C
L
H
I
D
P
D
K
R
P
F
C
A
E
L
L
H
H
D
F
F
Q
M
D
G
F
A
E
R
F
S
Q
E
L
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
87.45
49%
-98
- C1 -
-
4BBM
3
CDKL2_HUMAN
A:
[24-318]
M
E
K
Y
E
N
L
G
L
V
G
--
S
Y
G
M
V
M
K
C
R
N
K
D
T
G
R
I
V
A
I
K
K
F
L
E
S
D
D
D
K
M
V
K
K
I
A
M
R
E
I
K
L
L
K
Q
L
R
H
E
N
L
V
N
L
L
E
V
C
K
K
K
K
R
W
Y
L
V
F
E
F
V
D
H
T
I
L
D
D
L
E
-
L
F
P
N
G
L
D
Y
Q
V
V
Q
K
Y
L
F
Q
I
I
N
G
I
G
F
C
H
S
H
N
I
I
H
R
D
I
K
P
E
N
I
L
V
S
Q
S
G
V
V
K
L
C
D
F
G
F
A
R
-
T
L
A
A
P
G
E
V
Y
D
D
E
V
A
T
R
W
Y
R
A
P
E
L
L
V
G
D
V
K
Y
G
K
A
V
D
V
W
A
I
G
C
L
V
T
E
M
F
M
G
E
P
L
F
P
G
D
S
D
I
D
-
Q
-
L
Y
H
I
M
M
C
L
G
N
L
I
P
R
H
Q
E
L
F
N
K
N
-
P
V
F
A
G
V
R
L
P
E
------
I
K
E
R
E
-
P
L
E
R
R
Y
P
K
L
S
E
V
-
V
I
D
L
A
K
K
C
L
H
I
D
P
D
K
R
P
F
C
A
E
L
L
H
H
D
F
F
Q
M
D
G
F
A
E
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
85.14
46%
-125
- C1 -
-
4BGQ
3
CDKL5_HUMAN
A:
[11-298]
M
N
K
F
E
I
L
G
V
V
G
E
G
A
Y
G
V
V
L
K
C
R
H
K
E
T
H
E
I
V
A
I
K
K
F
K
-------
V
K
E
T
T
L
R
E
L
K
M
L
R
T
L
K
Q
E
N
I
V
E
L
K
E
A
F
R
R
R
G
K
L
Y
L
V
F
E
Y
V
E
K
N
M
L
E
L
L
E
-
E
M
P
N
G
V
P
P
E
K
V
K
S
Y
I
Y
Q
L
I
K
A
I
H
W
C
H
K
N
D
I
V
H
R
D
I
K
P
E
N
L
L
I
S
H
N
D
V
L
K
L
C
D
F
G
F
A
R
-
N
L
S
E
----------
T
R
W
Y
R
S
P
E
L
L
L
G
-
A
P
Y
G
K
S
V
D
M
W
S
V
G
C
I
L
G
E
L
S
D
G
Q
P
L
F
P
G
E
S
E
I
D
-
Q
-
L
F
T
I
Q
K
V
L
G
P
L
P
S
E
Q
M
K
L
F
Y
S
N
-
P
R
F
H
G
L
R
F
P
A
------
V
N
H
P
Q
-
S
L
E
R
R
Y
L
G
I
L
N
S
V
L
L
D
L
M
K
N
L
L
K
L
D
P
A
D
R
Y
L
T
E
Q
C
L
N
H
P
T
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
84.23
45%
-76
- C1 -
-
3ZDU
3
CDKL3_HUMAN
A:
[2-302]
M
E
M
Y
E
T
L
G
K
V
G
E
G
S
Y
G
T
V
M
K
C
K
H
K
N
T
G
Q
I
V
A
I
K
I
F
Y
--------
N
K
I
A
M
R
E
I
K
F
L
K
Q
F
H
H
E
N
L
V
N
L
I
E
V
F
R
Q
K
K
K
I
H
L
V
F
E
F
I
D
H
T
V
L
D
E
L
Q
-
H
Y
C
H
G
L
E
S
K
R
L
R
K
Y
L
F
Q
I
L
R
A
I
D
Y
L
H
S
N
N
I
I
H
R
D
I
K
P
E
N
I
L
V
S
Q
S
G
I
T
K
L
C
D
F
G
F
A
R
-
T
-----
D
I
Y
D
D
E
V
A
T
R
W
Y
R
A
P
E
L
V
L
K
D
T
S
Y
G
K
P
V
D
I
W
A
L
G
C
M
I
I
E
M
A
T
G
N
P
Y
L
P
S
S
S
D
L
D
-
L
-
L
H
K
I
V
L
K
V
G
N
L
S
P
H
L
Q
N
I
F
S
K
S
-
P
I
F
A
G
V
V
L
P
Q
------
V
Q
H
P
K
-
N
A
R
K
K
Y
P
K
L
N
G
L
-
L
A
D
I
V
H
A
C
L
Q
I
D
P
A
D
R
I
S
S
S
D
L
L
H
H
E
Y
F
T
R
D
G
F
I
E
K
F
M
P
E
L
K
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
83.50
50%
-92
- C1 -
-
4AGU
1
CDKL1_HUMAN
A:
[3-288]
-
E
K
Y
E
K
I
G
K
I
G
E
G
S
Y
G
V
V
F
K
C
R
N
R
D
T
G
Q
I
V
A
I
K
K
F
L
E
S
E
D
-
P
V
I
K
K
I
A
L
R
E
I
R
M
L
K
Q
L
K
H
P
N
L
V
N
L
L
E
V
F
R
R
K
R
R
L
H
L
V
F
E
Y
C
D
H
T
V
L
H
E
L
D
-
R
Y
Q
R
G
V
P
E
H
L
V
K
S
I
T
W
Q
T
L
Q
A
V
N
F
C
H
K
H
N
C
I
H
R
D
V
K
P
E
N
I
L
I
T
K
H
S
V
I
K
L
C
D
F
G
F
A
R
L
L
T
-------------
R
W
Y
R
S
P
E
L
L
V
G
D
T
Q
Y
G
P
P
V
D
V
W
A
I
G
C
V
F
A
E
L
L
S
G
V
P
L
W
P
G
K
S
D
V
D
-
Q
-
L
Y
L
I
R
K
T
L
G
D
L
I
P
R
H
Q
Q
V
F
S
T
N
-
Q
Y
F
S
G
V
K
I
P
D
------
P
E
D
M
E
-
P
L
E
L
K
F
P
N
I
S
Y
P
-
A
L
G
L
L
K
G
C
L
H
M
D
P
T
E
R
L
T
C
E
Q
L
L
H
H
P
Y
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
82.91
45%
-119
- C1 -
-
4BGQ
3
CDKL5_HUMAN
A:
[11-301]
M
N
K
F
E
I
L
G
V
V
G
E
G
A
Y
G
V
V
L
K
C
R
H
K
E
T
H
E
I
V
A
I
K
K
F
K
-------
V
K
E
T
T
L
R
E
L
K
M
L
R
T
L
K
Q
E
N
I
V
E
L
K
E
A
F
R
R
R
G
K
L
Y
L
V
F
E
Y
V
E
K
N
M
L
E
L
L
E
-
E
M
P
N
G
V
P
P
E
K
V
K
S
Y
I
Y
Q
L
I
K
A
I
H
W
C
H
K
N
D
I
V
H
R
D
I
K
P
E
N
L
L
I
S
H
N
D
V
L
K
L
C
D
F
G
F
A
R
-
N
L
S
E
----------
T
R
W
Y
R
S
P
E
L
L
L
G
-
A
P
Y
G
K
S
V
D
M
W
S
V
G
C
I
L
G
E
L
S
D
G
Q
P
L
F
P
G
E
S
E
I
D
-
Q
-
L
F
T
I
Q
K
V
L
G
P
L
P
S
E
Q
M
K
L
F
Y
S
N
-
P
R
F
H
G
L
R
F
P
A
------
V
N
H
P
Q
S
L
E
R
R
Y
L
G
I
L
N
S
V
-
L
L
D
L
M
K
N
L
L
K
L
D
P
A
D
R
Y
L
T
E
Q
C
L
N
H
P
T
F
Q
T
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
71.87
41%
-62
- C1 -
-
1BUH
-
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
-------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
-
Q
-
L
F
R
I
F
R
T
L
G
-
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
-
S
F
P
K
W
A
RQD
F
S
K
V
V
P
-
P
L
D
E
-------
D
-
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
70.72
41%
-60
- C1 -
-
5UQ2
-
CDK2_HUMAN
A:
[4-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
-
Q
-
L
F
R
I
F
R
T
L
G
-
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
-
S
F
P
K
W
A
R
QDF
S
K
V
V
P
-
P
L
D
E
-------
D
-
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
70.66
38%
-84
- C1 -
-
1V0B
-
CDC2H_PLAFK
A:
[1-286]
M
E
K
Y
H
G
L
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
Q
N
N
-
Y
G
E
T
F
A
L
K
K
I
R
L
E
K
E
D
E
G
I
P
S
T
T
I
R
E
I
S
I
L
K
E
L
K
H
S
N
I
V
K
L
Y
D
V
I
H
T
K
K
R
L
V
L
V
F
E
H
L
D
Q
D
L
K
K
L
L
D
-
V
C
E
G
G
L
E
S
V
T
A
K
S
F
L
L
Q
L
L
N
G
I
A
Y
C
H
D
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
R
E
G
E
L
K
I
A
D
F
G
L
A
R
-
A
F
G
I
P
V
R
K
Y
T
H
E
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
T
I
D
I
W
S
V
G
C
I
F
A
E
M
V
N
G
A
P
L
F
P
G
V
S
E
A
D
-
Q
-
L
M
R
I
F
R
I
L
G
T
P
N
S
K
N
W
P
N
V
T
E
L
-
P
K
Y
D
P
-
N
F
T
-------
V
Y
E
P
L
-
P
W
E
S
F
L
K
G
L
D
E
S
-
G
I
D
L
L
S
K
M
L
K
L
D
P
N
Q
R
I
T
A
K
Q
A
L
E
H
A
Y
F
K
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
70.34
41%
-63
- C1 -
-
5UQ1
-
CDK2_HUMAN
A:
[6-289]
--
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
------
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
-
Q
-
L
F
R
I
F
R
T
L
G
-
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
-
S
F
P
K
W
A
R
QDF
S
K
V
V
P
-
P
L
D
E
-------
D
-
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
69.84
41%
-52
- C1 -
-
1FVV
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
-
Q
-
L
F
R
I
F
R
T
L
G
-
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
-
S
F
P
K
W
A
R
Q
DF
S
K
V
V
P
-
P
L
D
E
-------
D
-
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
69.74
41%
-70
- C1 -
-
3PJ8
1
CDK2_HUMAN
A:
[2-287]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
---
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
--------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
-
Q
-
L
F
R
I
F
R
T
L
G
-
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
-
S
F
P
K
W
A
R
Q
D
F
S
K
V
V
P
-
P
L
D
E
-------
D
-
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
69.30
41%
-76
- C1 -
-
1DI8
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
------
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
---------
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
-
Q
-
L
F
R
I
F
R
T
L
G
-
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
-
S
F
P
K
W
A
R
Q
D
F
S
K
V
V
P
-
P
L
D
E
-------
D
-
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
68.92
41%
-61
- C1 -
-
1JSV
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
-----------
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
-
Q
-
L
F
R
I
F
R
T
L
G
-
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
-
S
F
P
K
W
A
R
Q
D
F
S
K
V
V
P
-
P
L
D
E
-------
D
-
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
68.81
41%
-54
- C1 -
-
1FIN
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
-
Q
-
L
F
R
I
F
R
T
L
G
-
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
-
S
F
P
K
W
A
R
Q
DF
S
K
V
V
P
-
P
L
D
E
-------
D
-
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
67.92
41%
-50
- C1 -
-
1F5Q
-
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
--
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
G
V
P
V
R
T
Y
T
H
E
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
-
Q
-
L
F
R
I
F
R
T
L
G
-
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
-
S
F
P
K
W
A
R
Q
DF
S
K
V
V
P
-
P
L
D
E
-------
D
-
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
67.81
41%
-81
- C1 -
-
1CKP
2
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
R
-
A
F
-----------
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
-
Q
-
L
F
R
I
F
R
T
L
G
-
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
-
S
F
P
K
W
A
RQDF
S
K
V
V
P
-
P
L
D
E
-------
D
-
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
65.51
41%
-75
- C1 -
-
1G5S
1
CDK2_HUMAN
A:
[1-286]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
---------
S
T
A
I
R
E
I
S
L
L
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
F
L
H
Q
D
L
K
K
F
M
D
A
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
---------------
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
G
D
S
E
I
D
-
Q
-
L
F
R
I
F
R
T
L
G
-
T
P
D
E
V
V
W
P
G
V
T
S
M
P
D
Y
K
P
-
S
F
P
K
W
A
R
QDF
S
K
V
V
P
-
P
L
D
E
-------
D
-
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
64.73
37%
-82
* C1 *
-
4AU8
2
CDK5_HUMAN
A:
[6-293]
-
Q
K
Y
E
K
L
E
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
R
E
T
H
E
I
V
A
L
K
R
V
---------
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
H
K
N
I
V
R
L
H
D
V
L
H
---
K
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
-
S
C
N
G
D
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
R
N
G
E
L
K
L
A
D
F
G
L
A
R
-
A
F
G
I
P
V
R
--
S
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
R
P
L
F
P
G
N
D
V
D
D
Q
-
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
T
K
L
-
P
D
Y
K
P
Y
--
P
M
------
Y
P
A
T
T
-
S
L
V
N
V
V
P
K
L
N
A
T
-
G
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
S
D
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
61.55
36%
-44
- C1 -
-
1UNL
1
CDK5_HUMAN
A:
[1-289]
M
Q
K
Y
E
K
L
E
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
R
E
T
H
E
I
V
A
L
K
R
V
R
L
D
D
D
D
E
G
V
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
H
K
N
I
V
R
L
H
D
V
L
H
S
D
K
K
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
-
S
C
N
G
D
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
R
N
G
E
L
K
L
A
N
F
G
L
A
R
-
A
F
G
I
P
V
R
C
Y
S
A
E
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
R
P
L
F
P
G
N
D
V
D
-
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
T
K
L
-
P
D
Y
K
P
Y
P
M
--------
Y
P
A
T
T
-
S
L
V
N
V
V
P
K
L
N
A
T
-
G
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
S
D
F
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