@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_33_1930: (2018-03-12 )
MHPEDGLGTSGAAPISASEALHSFGGCLTAYERKEIVQYETIHYVGQRCVDKMGSPTNGRNDGYDTEEGEYIFRVKDHIAYRYEILKELGSGAFGQVFKAIDHLDSSIVAVKMIRNQRKVLQQAEQEIHMLQHVNDRDPKGLYGIVRMTDNFKFRGHTCVSYELLGANLYEYLKANNFFPMTLSLIRSIAARVLVALTFLARENIIHCDLKPENILLRDNDPSVVKVIDLGSASFDVKNMYTYIQSRFYRAPEVIMEQKYDKAIDWWSFGCILCELANGDPVFPGEDEKDQLGCIMEYLGPPPQSFVEASSARRRREFFDERYKPRPRTTCKGKQREPGSRSLAKFVAVSEDDDFLSFVRLFLQWEPSKRVPPREAMKHRWICGEFVFPNQSEEKPELSSLTKESNGSAAGSLKACMPQEPAAPLKTEASTSTTVGQPFTARGAPADLLSPSAAHQRVQRPAPLPQPPTACTSRANCNALSGDGVISVDTLPCSRDASASTETRGAARLTDAKVQRPPAQRRQSGRLQRGRQRRSTDMADVEMPGEAITSPNHSTSLHAPWDAEESSAEQRTREFIIAANSASSPSSSACGTATRATNARPHEVRLANRVLSSEVLSAAILRSSANPIIFTSRGRNAHSPENKASPNASHSKITNGGAVGNARGGDSAGDVHTGVLELRQKYADSKTKAGTVDLVDRSGSVIAFDSLSRWPNTAGKTQLGGRRQGSASAPDRLDSRGRTSPGVSTESPRGQPRGERREYSINLDAATLPPTEVYQPAAVKGSLHAGEYMLPSELQPFSEDGRSSSPHDVEVAPKCRLLAAMMSEPRDKSEKSQLSLQPRGSSPPSSSGPSAVATPSLRPQYTRRQRSTQCSMLAMRDGGAAHAAARSQRSVAGAAAPMSWKRPAVQPSDVPLVPPRQTLTQRSLLPQRNGAGTRGGDVGKPSTTPTPQLPSLKRYSAH
Atome Classification :
(21 SA)
.........10........20........30........40........50........60........70........80........90........100-.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.--........210.......220------------........230.......240.......250.......260.......270.......280.......290.......300.......310.......----320.....---.----------------.330--------------.-..-...-..340...--..-----------------..350.--------------......360..---.....370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MHPEDGLGTSGAAPI
S
A
S
E
A
L
H
SF
G
G
C
L
T
A
Y
E
R
K
E
I
V
Q
Y
E
T
I
H
Y
V
G
Q
R
C
V
D
KMGSPTNGRNDGYDTEEG
E
Y
I
F
R
V
K
D
H
I
A
Y
R
Y
E
I
L
K
E
LGS
G
A
F
G
Q
V
F
K
A
I
D
-
H
LD
S
S
I
V
A
V
K
M
I
R
N
Q
R
K
V
L
Q
Q
A
E
Q
E
I
H
M
L
Q
HVNDRDPKG
L
Y
G
I
V
R
MTDN
F
K
FRG
H
T
C
V
S
Y
E
L
L
G
A
N
L
Y
E
Y
L
K
ANNFF
P
M
T
L
S
L
I
R
S
I
A
A
R
V
L
V
A
L
T
F
L
--A--RE
N
I
I
H
CDLKPE
N
I
L
L
RDND-------------P
S
V
V
K
V
I
DLGSASF
D
V
K
N
M
Y
T
Y
I
Q
S
R
FYRA
P
E
V
I
M
E
Q
K
Y
D
KAI
D
W
W
S
F
G
C
I
L
CELANGDPVFPGEDE
K
D
Q
L
G
C
I
M
E
Y
LGP
P
P
Q
S
F
V
E
A
S
S
A
R
R
R
R
E
F
F
----
D
E
RYKPRP---R----------------TTC---------------K-GK-QRE-PG
S
R
S
L
A
K
--
F
V
-----------------AVSEDD--------------
D
F
L
S
F
V
R
L
F
LQ---WEPSKRVP
P
R
E
A
M
K
HRWICGEFVFPNQSEEKP
E
L
S
S
L
T
KESNGSAAGS
L
K
ACMPQEPAAPLKTEASTSTTVGQPFTARGA
P
A
DLLS
P
S
A
A
H
Q
RVQRPAPLPQPPTACTSRANCNALSGD
G
V
I
S
V
DTLPCSRDASASTETRGAARLTDAKVQRP
P
A
Q
R
R
QSG
R
L
Q
RGRQRRSTDMADVEMPGEAITSPNHSTSLHAPWDAEE
S
S
A
E
Q
R
T
R
E
F
I
I
A
ANSASSPSSSACGTATRATNARP
H
E
V
R
L
A
N
R
V
L
S
S
E
V
L
S
A
A
I
L
RSSAN
P
I
I
F
TSRGRNAHSPENKASPNASHSKITNGGAVGNARGGDSAG
D
V
H
T
G
V
L
E
L
R
Q
K
YADSKTKAG
T
V
D
L
VDRSG
S
V
I
A
F
D
S
L
SRWPNTAGKTQLGGRRQGSASAPDRLDSRGRTSPGVSTESPRGQPRGER
R
E
Y
S
I
NLDAATL
P
P
T
EVYQPAAVKGSLHAGEYMLPSELQPFSEDGRSSSPHDVEV
A
P
K
C
R
L
L
A
A
M
M
SEPRDKSEKS
Q
L
S
LQPRGSSPPSSSGPSAVATPSLR
P
Q
Y
T
R
R
QRSTQ
C
S
M
L
A
MRDGG
A
A
H
A
A
A
RSQRSVAGAAAPMSWKRPAVQPSDVPLVP
P
R
Q
T
L
T
Q
RSLLPQRNGAGTRGGDVGKPSTTPTPQLPSLKRYSAH
3
PsiBlast_PDB
93.18
41%
-83
- C1 -
-
3KVW
1
DYRK2_HUMAN
A:
[23-412]
------
M
G
K
V
K
A
T
P
M
T
P
E
Q
A
M
K
Q
Y
M
Q
K
L
T
A
F
E
H
H
E
I
F
S
Y
P
E
I
Y
F
L
G
L
N
A
K
K
R
Q
G
M
T
G
G
P
N
N
G
G
Y
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
H
K
V
H
Q
H
V
A
L
K
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
N
V
I
H
M
L
E
N
F
T
F
R
N
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
--
H
--
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
K
Q
Q
G
-------------
R
S
G
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
R
V
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
D
A
S
--
K
R
A
K
N
F
V
----
S
S
K
G
Y
P
R
Y
---
C
----------------
T
V
T
TLS
D
V
V
L
N
G
G
RSR--
R
-
G
K
-
L
R
G
P
P
E
S
R
E
W
G
N
--
A
L
-----------------
K
G
C
D
D
P
--------------
L
F
L
D
F
L
K
Q
C
L
E
---
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
92.99
41%
-80
- C1 -
-
5LXD
6
DYRK2_HUMAN
A:
[9-391]
-------------
P
M
T
P
E
Q
A
M
K
Q
Y
M
Q
K
L
T
A
F
E
H
H
E
I
F
S
Y
P
E
I
Y
F
L
G
L
N
A
K
K
R
Q
G
M
T
G
G
P
N
N
G
G
Y
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
H
K
V
H
Q
H
V
A
L
K
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
N
V
I
H
M
L
E
N
F
T
F
R
N
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
--
H
--
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
K
Q
Q
G
-------------
R
S
G
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
R
V
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
D
A
S
--
K
R
A
K
N
F
V
----
S
S
K
G
Y
P
R
Y
---
C
----------------
T
V
T
TLSD
G
S
V
V
L
N
G
G
R
SR
R
-
G
K
-
L
R
G
P
P
E
S
R
E
W
G
N
--
A
L
-----------------
K
G
C
D
D
P
--------------
L
F
L
D
F
L
K
Q
C
L
E
---
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
92.21
43%
-81
- C1 -
-
4AZF
2
DYRK2_HUMAN
A:
[29-413]
------------
T
P
M
T
P
E
Q
A
M
K
Q
Y
M
Q
K
L
T
A
F
E
H
H
E
I
F
S
Y
P
E
I
Y
F
L
G
L
N
A
K
K
R
Q
G
M
T
G
G
P
N
N
G
G
Y
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
H
K
V
H
Q
H
V
A
L
K
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
N
V
I
H
M
L
E
N
F
T
F
R
N
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
--
H
--
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
K
Q
Q
G
-------------
R
S
G
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
R
V
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
D
A
S
--
K
R
A
K
N
F
V
----
S
S
K
G
Y
P
R
Y
---
C
T
V
T
TLS
D
V
V
L
N
G
----
G
R
S
R--------------
R
-
G
K
L
R
G
P
-
P
E
S
R
E
W
G
N
--
A
L
-----------------
K
G
C
D
D
P
--------------
L
F
L
D
F
L
K
Q
C
L
E
---
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
91.93
41%
-76
- C1 -
-
3K2L
-
DYRK2_HUMAN
A:
[23-412]
------
M
G
K
V
K
A
T
P
M
T
P
E
Q
A
M
K
Q
Y
M
Q
K
L
T
A
F
E
H
H
E
I
F
S
Y
P
E
I
Y
F
L
G
L
N
A
K
K
R
Q
G
M
T
G
-
P
N
N
G
G
Y
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
H
K
V
H
Q
H
V
A
L
K
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
N
V
I
H
M
L
E
N
F
T
F
R
N
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
--
H
--
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
K
Q
Q
G
-------------
R
S
G
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
R
V
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
D
A
S
--
K
R
A
K
N
F
V
----
S
S
K
G
Y
P
R
Y
---
C
----------------
T
V
T
TLSDG
S
V
V
L
NGG
R
S
R
R
-
G
K
-
L
R
G
P
P
E
S
R
E
W
G
N
--
A
L
-----------------
K
G
C
D
D
P
--------------
L
F
L
D
F
L
K
Q
C
L
E
---
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
91.69
41%
-80
- C1 -
-
5LXC
10
DYRK2_HUMAN
A:
[9-391]
-------------
P
M
T
P
E
Q
A
M
K
Q
Y
M
Q
K
L
T
A
F
E
H
H
E
I
F
S
Y
P
E
I
Y
F
L
G
L
N
A
K
K
R
Q
G
M
T
G
G
P
N
N
G
G
Y
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
H
K
V
H
Q
H
V
A
L
K
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
N
V
I
H
M
L
E
N
F
T
F
R
N
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
--
H
--
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
K
Q
Q
G
-------------
R
S
G
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
R
V
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
D
A
S
--
K
R
A
K
N
F
V
----
S
S
K
G
Y
P
R
Y
---
C
----------------
T
V
T
T
LSD
G
S
V
V
L
N
G
G
R
SR
R
-
G
K
-
L
R
G
P
P
E
S
R
E
W
G
N
--
A
L
-----------------
K
G
C
D
D
P
--------------
L
F
L
D
F
L
K
Q
C
L
E
---
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
91.57
41%
-81
- C1 -
-
4AZF
2
DYRK2_HUMAN
A:
[23-412]
------
M
G
K
V
K
A
T
P
M
T
P
E
Q
A
M
K
Q
Y
M
Q
K
L
T
A
F
E
H
H
E
I
F
S
Y
P
E
I
Y
F
L
G
L
N
A
K
K
R
Q
G
M
T
G
G
P
N
N
G
G
Y
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
H
K
V
H
Q
H
V
A
L
K
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
N
V
I
H
M
L
E
N
F
T
F
R
N
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
--
H
--
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
K
Q
Q
G
-------------
R
S
G
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
R
V
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
D
A
S
--
K
R
A
K
N
F
V
----
S
S
K
G
Y
P
R
Y
---
C
----------------
T
V
T
TLS
D
V
V
L
N
G
G
RSR--
R
-
G
K
-
L
R
G
P
P
E
S
R
E
W
G
N
--
A
L
-----------------
K
G
C
D
D
P
--------------
L
F
L
D
F
L
K
Q
C
L
E
---
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
91.19
42%
-80
- C1 -
-
5LXC
10
DYRK2_HUMAN
A:
[9-392]
-------------
P
M
T
P
E
Q
A
M
K
Q
Y
M
Q
K
L
T
A
F
E
H
H
E
I
F
S
Y
P
E
I
Y
F
L
G
L
N
A
K
K
R
Q
G
M
T
G
G
P
N
N
G
G
Y
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
H
K
V
H
Q
H
V
A
L
K
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
N
V
I
H
M
L
E
N
F
T
F
R
N
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
--
H
--
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
K
Q
Q
G
-------------
R
S
G
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
R
V
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
D
A
S
K
--
R
A
K
N
F
V
----
S
S
K
G
Y
P
R
Y
---
C
T
V
T
T
LSD
G
S
V
V
L
N
G
G
R
S
R
R
---------------
G
-
K
L
-
R
G
P
-
P
E
S
R
E
W
G
N
--
A
L
-----------------
K
G
C
D
D
P
--------------
L
F
L
D
F
L
K
Q
C
L
E
---
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
74.94
38%
-49
- C1 -
-
3ANQ
1
DYR1A_HUMAN
A:
[36-357]
---------------------------------------------------------------------------------
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
V
E
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
Y
Y
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
--
A
TP
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
P
K
-------------
R
S
A
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
--
Q
A
P
K
A
R
K
F
F
E
K
LP
D
G
T
W
N
L
K
K
----------------------------------------
R
E
-
Y
K
P
-
P
G
T
R
K
L
H
N
--
I
L
-----------------
G
V
E
T
G
G
PGGRRAGESGH
T
V
A
D
Y
L
K
F
K
D
L
I
L
R
M
LD
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
74.60
38%
-47
- C1 -
-
4NCT
1
DYR1A_HUMAN
A:
[36-357]
---------------------------------------------------------------------------------
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
V
E
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
Y
Y
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
--
A
TP
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
P
K
-------------
R
S
A
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
--
Q
A
P
K
A
R
K
F
F
E
K
LP
D
G
T
W
N
L
K
K
---
T
-------------------------------------
E
-
Y
K
P
-
P
G
T
R
K
L
H
N
--
I
L
-----------------
G
V
E
T
G
G
PGGRRAGESGH
T
V
A
D
Y
L
K
F
K
D
L
I
L
R
M
LD
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
74.57
38%
-48
- C1 -
-
5A4T
1
DYR1A_HUMAN
A:
[36-357]
---------------------------------------------------------------------------------
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
V
E
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
Y
Y
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
--
A
TP
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
P
K
-------------
R
S
A
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
--
Q
A
P
K
A
R
K
F
F
E
K
LP
D
G
T
W
N
L
K
K
---
T
-------------------------------------
E
-
Y
K
P
-
P
G
T
R
K
L
H
N
--
I
L
-----------------
G
V
E
T
G
G
PGGRRAGESGH
T
V
A
D
Y
L
K
F
K
D
L
I
L
R
M
LD
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
74.31
40%
-54
* C1 *
-
4YU2
2
DYR1A_HUMAN
A:
[12-358]
-----------------------------------------------------------
Y
N
D
G
Y
D
D
D
N
Y
D
Y
I
V
K
N
G
E
K
W
M
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
V
E
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
Y
Y
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
--
A
TP
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
P
K
-------------
R
S
A
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
A
--
P
K
A
R
K
F
F
----
E
K
L
P
D
G
T
W
N
L
K
K
T---------------
K
D
G
---------------
K
-
R
E
-
Y
K
P
-
P
G
T
R
K
L
H
N
--
I
L
GVETGGPGGRRAGESGH
T
V
A
D
Y
L
--------------
K
F
K
D
L
I
L
R
M
L
D
---
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
74.08
38%
-52
- C1 -
-
5AIK
1
DYR1A_HUMAN
A:
[55-376]
---------------------------------------------------------------------------------
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
V
E
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
Y
Y
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
--
A
TP
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
P
K
-------------
R
S
A
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
--
Q
A
P
K
A
R
K
F
F
E
K
LP
D
G
T
W
N
L
K
K
---
T
----------------------------------
K
-
R
E
-
Y
K
P
-
P
G
T
R
K
L
H
N
--
I
L
-----------------
G
V
E
T
G
G
PGGRRAGESGH
T
V
A
D
Y
L
K
F
K
D
L
I
L
R
M
LD
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
73.73
38%
-49
- C1 -
-
4MQ2
3
DYR1A_HUMAN
A:
[34-355]
---------------------------------------------------------------------------------
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
V
E
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
Y
Y
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
--
A
TP
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
P
K
-------------
R
S
A
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
--
Q
A
P
K
A
R
K
F
F
E
K
LP
D
G
T
W
N
L
K
K
---
T
----------------
K
-----------------
K
-
R
E
-
Y
K
P
-
P
G
T
R
K
L
H
N
--
I
L
-----------------
G
V
E
T
G
G
PGGRRAGESGH
T
V
A
D
Y
L
K
F
K
D
L
I
L
R
M
LD
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
73.61
38%
-53
- C1 -
-
4YLJ
3
DYR1A_HUMAN
A:
[34-355]
---------------------------------------------------------------------------------
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
V
E
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
Y
Y
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
--
A
TP
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
P
K
-------------
R
S
A
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
--
Q
A
P
K
A
R
K
F
F
E
K
LP
D
G
T
W
N
L
K
K
---
T
----------------
K
D
G
---------------
K
-
R
E
-
Y
K
P
-
P
G
T
R
K
L
H
N
--
I
L
-----------------
G
V
E
T
G
G
PGGRRAGESGH
T
V
A
D
Y
L
K
F
K
D
L
I
L
R
M
LD
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
73.32
38%
-50
- C1 -
-
2WO6
1
DYR1A_HUMAN
A:
[55-376]
---------------------------------------------------------------------------------
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
V
E
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
Y
Y
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
--
A
TP
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
P
K
-------------
R
S
A
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
--
Q
A
P
K
A
R
K
F
F
E
K
LP
D
G
T
W
N
L
K
K
---
T
------------------------------------
R
E
-
Y
K
P
-
P
G
T
R
K
L
H
N
--
I
L
-----------------
G
V
E
T
G
G
PGGRRAGESGH
T
V
A
D
Y
L
K
F
K
D
L
I
L
R
M
LD
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
73.14
38%
-49
- C1 -
-
3ANR
1
DYR1A_HUMAN
A:
[36-357]
---------------------------------------------------------------------------------
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
V
E
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
Y
Y
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
--
A
TP
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
P
K
-------------
R
S
A
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
--
Q
A
P
K
A
R
K
F
F
E
K
LP
D
G
T
W
N
L
K
K
---
T
-------------------------------------
E
-
Y
K
P
-
P
G
T
R
K
L
H
N
--
I
L
-----------------
G
V
E
T
G
G
PGGRRAGESGH
T
V
A
D
Y
L
K
F
K
D
L
I
L
R
M
LD
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
73.08
38%
-44
- C1 -
-
5A54
1
DYR1A_HUMAN
A:
[36-357]
---------------------------------------------------------------------------------
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
V
E
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
Y
Y
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
--
A
TP
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
P
K
-------------
R
S
A
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
--
Q
A
P
K
A
R
K
F
F
E
K
LP
D
G
T
W
N
L
K
K
---
T
-------------------------------------
E
-
Y
K
P
-
P
G
T
R
K
L
H
N
--
I
L
-----------------
G
V
E
T
G
G
PGGRRAGESGH
T
V
A
D
Y
L
K
F
K
D
L
I
L
R
M
LD
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
73.05
39%
-54
- C1 -
-
4YLL
10
DYR1A_HUMAN
A:
[13-357]
------------------------------------------------------------
N
D
G
Y
D
D
D
N
Y
D
Y
I
V
K
N
G
E
K
W
M
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
V
E
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
-
K
Y
Y
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
T
P
--
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
P
K
-------------
R
S
A
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
A
P
--
K
A
R
K
F
F
----
E
K
L
P
D
G
T
W
N
L
K
K
-------------------------------------
E
-
Y
K
P
-
P
G
T
R
K
L
H
N
--
I
L
GVETGGPGGRRAGESGH
T
V
A
D
Y
L
--------------
K
F
K
D
L
I
L
R
M
L
D
---
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
72.51
38%
-49
- C1 -
-
5A3X
1
DYR1A_HUMAN
A:
[36-357]
---------------------------------------------------------------------------------
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
V
E
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
Y
Y
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
--
A
TP
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
P
K
-------------
R
S
A
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
--
Q
A
P
K
A
R
K
F
F
E
K
LP
D
G
T
W
N
L
K
K
---
T
-------------------------------------
E
-
Y
K
P
-
P
G
T
R
K
L
H
N
--
I
L
-----------------
G
V
E
T
G
G
PGGRRAGESGH
T
V
A
D
Y
L
K
F
K
D
L
I
L
R
M
LD
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
72.48
38%
-50
- C1 -
-
5A4L
1
DYR1A_HUMAN
A:
[36-357]
---------------------------------------------------------------------------------
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
V
E
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
Y
Y
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
--
A
TP
E
L
S
I
I
H
C
D
L
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P
E
N
I
L
L
C
N
P
K
-------------
R
S
A
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Q
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L
L
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--
Q
A
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A
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F
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LP
D
G
T
W
N
L
K
K
---
T
-------------------------------------
E
-
Y
K
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-
P
G
T
R
K
L
H
N
--
I
L
-----------------
G
V
E
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PGGRRAGESGH
T
V
A
D
Y
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K
D
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LD
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Y
A
L
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H
S
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
67.06
35%
-38
- C1 -
-
1Z57
1
CLK1_HUMAN
A:
[10-335]
----------------------------------------------------------------------------
D
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---
K
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----
H
H
D
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-
D
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---
D
----------------
E
H
S
---------------
S
A
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R
-
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A
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K
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L
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FM
L
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-----------------
Q
D
V
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H
E
--------------
R
L
F
D
L
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L
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---
Y
D
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L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------