@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_33_2100: (2018-03-12 )
MAEAIPISSQQVSDNGEVELQFKDILGPIGCKTCKYERVRELGSGSFGKALLVRRVSDGQLLVAKRMDLAAMSEKDTKYATAEIQCLASCDHFAIIKYYEDYVAEPHMLIIMEFADAGDLNMQIKQRAKAGFIYFEEHEVGYTFVQLAMAVDHIHRRRMLHRDIKGANVMLMTNGVIKLGDFGFSHQYENTVSDQVAQTFCGTPYYLAPELWNHQRYSKKADVWAMGILLFEMMALRRPFVGQGMRALSEAVMSNRRDCELPQQYSRSLKDLCNIMLRTDPNQRPSCAQLFKLPHMMKLLLDFGTSVDNSQLVSDALKKKIHANICEIRDTSVNDPETFTFVGHVGTVSSSVFYEGYVRKESGKTWKERFLVLRDGGLVISRHKGDKETKPLPVTFINSAVFVPEQSACSTGVFAINLADTKTMWFQALPPETAEIWVHKIQQSIGVS
Atome Classification :
(20 SA)
-----------------------------------------------------------------------------------------------------------------------------------.........10........20....-....30........40........50........60........70..---...-...80........90........100.....--..110.......120.......130.......140.......150......-----.160.......170--.--.---.....180.......190.......200.......210.---...-...220.......230.......240.......250.....---.--.260.--......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-----------------------------------------------------------------------------------------------------------------------------------MAEAIPISSQQVSDN
G
E
V
E
L
Q
F
K
DI-LGPIGCKT
C
K
Y
E
R
V
R
E
LGSGSF
G
K
A
L
L
V
R
RVSDG
Q
L
L
V
A
KRM
D
L
A
AMS---EKD-TKYA
T
A
E
I
Q
C
LASCD
H
F
A
I
I
K
Y
Y
E
D
Y
VAEP
H
--
M
L
I
I
M
E
FADAGDL
N
M
Q
I
K
Q
RAKA
G
F
I
Y
F
E
EHEV
G
Y
T
F
V
Q
L
A
M
A
V
D
H
I
H
R
R
R
-----
M
L
H
RDIKGA
N
V
M
L
M
--T--N---
G
V
I
K
LGDFGFS
H
Q
YE
N
T
V
S
D
Q
V
A
Q
T
FCGTPYYL
A
P
E
LWN---
H
Q
R
-
Y
SKK
A
D
V
W
A
M
G
I
L
L
F
E
M
M
A
LRR
P
F
V
G
Q
G
M
R
A
L
S
E
A
V
M
SNRR---D--CEL
P
Q
--
Q
Y
S
R
S
L
K
D
L
C
N
I
M
LRTDPNQR
P
S
C
A
Q
L
F
K
L
P
H
M
M
K
L
L
L
DFGTSVD
N
S
Q
L
V
S
D
A
L
K
K
K
I
H
A
N
I
C
E
IRDTSVNDP
E
T
F
T
F
V
GHVGTVSSS
V
F
Y
E
G
Y
V
RKESGK
T
W
K
E
R
F
L
V
L
RDG
G
L
V
I
S
RHKGDKETK
P
L
P
V
T
F
IN
S
A
VFVPEQSACST
G
V
F
A
I
NLADT
K
T
M
W
F
QALPP
E
T
A
E
I
W
V
H
K
I
Q
Q
S
IGVS
2
PsiBlast_PDB
75.78
33%
-147
- C1 -
-
4B9D
1
NEK1_HUMAN
A:
[25-287]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
V
R
L
Q
K
I
------
K
A
I
L
V
K
S
T
E
D
G
R
Q
Y
V
I
K
E
I
N
I
S
R
M
S
---
S
K
E
-
R
E
E
S
R
R
E
V
A
V
L
A
N
M
K
H
P
N
I
V
Q
Y
R
E
S
F
E
E
N
G
S
--
L
Y
I
V
M
D
Y
C
E
G
G
D
L
F
K
R
I
N
--
A
Q
K
G
-
V
L
F
Q
E
D
Q
I
L
D
W
F
V
Q
I
C
L
A
L
K
H
V
H
D
R
K
-----
I
L
H
R
D
I
K
S
Q
N
I
F
L
T
--
K
--
D
---
G
T
V
Q
L
G
D
F
G
I
A
R
V
L
N
S
T
V
--
E
L
A
R
A
C
I
G
T
P
Y
Y
L
S
P
E
I
C
E
---
N
K
P
-
Y
N
N
K
S
D
I
W
A
L
G
C
V
L
Y
E
L
C
T
L
K
H
A
F
E
A
G
S
M
K
N
L
V
L
K
I
I
S
G
S
F
---
P
---
P
V
S
L
--
H
Y
S
Y
D
L
R
S
L
V
S
Q
L
F
K
R
N
P
R
D
R
P
S
V
N
S
I
L
E
K
G
F
I
A
K
R
I
E
K
F
-------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
75.18
33%
-149
- C1 -
-
4APC
-
NEK1_HUMAN
A:
[25-287]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Y
V
R
L
Q
K
I
------
K
A
I
L
V
K
S
T
E
D
G
R
Q
Y
V
I
K
E
I
N
I
S
R
M
S
---
S
K
E
-
R
E
E
S
R
R
E
V
A
V
L
A
N
M
K
H
P
N
I
V
Q
Y
R
E
S
F
E
E
N
G
S
--
L
Y
I
V
M
D
Y
C
E
G
G
D
L
F
K
R
I
N
--
A
Q
K
G
-
V
L
F
Q
E
D
Q
I
L
D
W
F
V
Q
I
C
L
A
L
K
H
V
H
D
R
K
-----
I
L
H
R
D
I
K
S
Q
N
I
F
L
T
--
K
--
D
---
G
T
V
Q
L
G
D
F
G
I
A
R
V
L
N
S
T
V
--
E
L
A
R
A
C
I
G
T
P
Y
Y
L
S
P
E
I
C
E
---
N
K
P
-
Y
N
N
K
S
D
I
W
A
L
G
C
V
L
Y
E
L
C
T
L
K
H
A
F
E
A
G
S
M
K
N
L
V
L
K
I
I
S
G
S
F
---
P
---
P
V
S
L
--
H
Y
S
Y
D
L
R
S
L
V
S
Q
L
F
K
R
N
P
R
D
R
P
S
V
N
S
I
L
E
K
G
F
I
A
K
R
I
E
K
F
-------------------------------------------------------------------------------------------------------------------------------------------------
56
Fugue
73.22
21%
26
- C1 -
-
3C4Z
1
RK_BOVIN
A:
[31-533]
------------RD
R
K
Y
L
A
R
LKLPPLSKC
E
A
L
R
E
S
LDLGFEGMCLEQ
P
I
G
K
R
L
F
Q
Q
F
L
R
T
H
EQH
G
P
A
L
Q
L
W
K
D
I
E
D
Y
D
T
ADDAL
R
P
Q
K
A
Q
A
L
R
A
A
YLEPQAQLFCSFLD
A
E
T
V
A
R
A
R
AGGLF
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
R
F
L
Q
W
K
W
L
E
A
Q
P
M
G
E
D
W
--
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
K
A
T
G
K
L
Y
A
C
K
K
L
N
K
K
R
L
K
---
K
R
K
G
Y
Q
G
A
M
V
E
K
K
I
L
A
K
V
H
S
R
F
I
V
S
L
A
Y
A
F
E
T
K
T
D
--
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
V
D
E
D
N
P
-
G
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
R
N
-----
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
--
D
--
D
---
G
N
V
R
I
S
D
L
G
L
A
V
E
L
K
A
--
G
Q
T
K
T
K
G
Y
A
G
T
P
G
F
M
A
P
E
L
L
L
---
G
E
E
-
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
R
A
R
G
E
K
V
E
N
K
E
L
K
Q
R
V
L
---
E
Q
A
V
T
Y
P
D
--
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
F
R
D
------------
G
S
C
D
G
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
--
M
L
T
P
P
F
V
P
D
S
R
T
-------------------------------------------
V
Y
A
K
N
G
A
F
S
G
V
A
F
E
K
A
D
T
E
F
F
Q
E
F
A
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
--
V
F
G
D
L
N
V
W
R
P
--------------
55
Fugue
72.25
21%
13
- C1 -
-
2ACX
1
GRK6_HUMAN
A:
[14-532]
KARKGKSKK
W
R
Q
M
L
QFPHISQC
E
E
L
R
L
S
LERD
Y
H
S
L
C
ERN
P
I
G
R
L
L
F
R
E
F
C
A
T
R
P
E
L
S
R
C
V
A
F
L
D
G
V
A
E
Y
E
V
TPDDK
R
K
A
C
G
R
N
L
T
Q
N
FLSHTGPDLIPEVP
R
Q
L
V
T
N
C
T
Q
R
L
E
Q
GPCKDLF
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
-
E
R
Q
-
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
R
A
T
G
K
M
Y
A
C
K
K
L
E
K
K
R
I
K
---
K
R
K
G
E
A
M
A
L
N
E
K
Q
I
L
E
K
V
N
S
R
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
--
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
M
G
Q
A
G
F
---
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
E
R
-----
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
--
D
--
H
---
G
H
I
R
I
S
D
L
G
L
A
V
H
V
P
E
---
G
Q
T
I
K
G
R
V
G
T
V
G
Y
M
A
P
E
V
V
K
---
N
E
R
-
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
F
Q
Q
R
K
K
K
I
K
R
E
E
V
E
R
L
V
K
E
V
-
P
--
E
E
Y
S
E
--
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
G
C
R
G
------------
G
S
A
R
E
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
G
-----------
M
L
E
P
P
F
K
P
D
P
Q
A
I
Y
C
E
P
T
D
Q
D
F
Y
Q
K
F
A
T
G
S
----------------------
V
P
I
P
W
Q
N
E
M
V
E
T
E
C
F
Q
E
L
N
V
F
G
L
D
G
S
-----------------------------------
34
HHSearch
64.50
30%
-122
- C1 -
-
5K00
1
MELK_HUMAN
A:
[6-266]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
--
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
N
T
L
----
G
S
D
-
L
P
R
I
K
T
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
--
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
-----
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
-----
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
--
E
--
Y
---
H
K
L
K
L
I
D
F
G
L
C
A
K
P
--------------
S
L
A
Y
A
A
P
E
L
I
Q
---
G
K
S
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
K
-------
Y
D
V
P
K
--
W
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
L
L
N
H
P
W
I
M
Q
D
Y
----------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
64.40
33%
-32
- C1 -
-
5M51
1
NEK2_HUMAN
A:
[8-273]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
V
L
Y
T
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
T
---
E
A
E
-
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
-
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
DG
G
H
T
V
L
H
R
D
L
K
P
A
N
V
F
L
D
--
G
--
K
---
Q
N
V
K
L
G
D
F
------------------
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
---
R
M
S
-
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
F
---
R
---
R
I
P
Y
--
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
64.18
33%
-37
- C1 -
-
2W5A
5
NEK2_HUMAN
A:
[8-273]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
V
L
Y
T
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
T
---
E
A
E
-
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
-
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
------
L
H
R
D
L
K
P
A
N
V
F
L
D
--
G
--
K
---
Q
N
V
K
L
G
D
F
G
L
A
R
I
L
---
T
S
--
F
A
K
T
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
---
R
M
--
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
F
---
R
---
R
I
P
Y
--
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
------------------------------------------------------------------------------------------------------------------------------------------------------
47
HHSearch
60.64
27%
-108
- C1 -
-
4XBR
1
INKA1_HUMAN (first)
A:
[93-350]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
-----
Q
Q
R
-
R
E
L
L
F
N
E
V
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
E
--
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
T
------
R
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
-----
V
I
H
R
D
I
K
S
D
S
I
L
L
T
--
H
--
D
---
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
--
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
---
R
L
P
-
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P--
R
--
L
K
N
L
H
--
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
A
K
A
-----------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
59.99
33%
-40
- C1 -
-
2XNM
10
NEK2_HUMAN
A:
[8-273]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
V
L
Y
T
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
T
---
E
A
E
-
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
-
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
---------
R
D
L
K
P
A
N
V
F
L
D
--
G
--
K
---
Q
N
V
K
L
G
D
F
G
L
A
R
I
L
-----------
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
---
R
-
S
-
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
F
---
R
---
R
I
P
Y
--
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
------------------------------------------------------------------------------------------------------------------------------------------------------
53
Fugue
59.57
21%
-59
- C1 -
-
1TKI
-
TITIN_HUMAN
A:
[18-338]
--------------------------------------------------------------------------------------------------------------------------------------------
K
E
L
Y
E
---------------------
K
Y
M
I
A
E
D
L
G
R
G
E
F
G
I
V
H
R
C
V
E
T
S
S
K
K
T
Y
M
A
K
F
V
K
---
V
K
---
G
T
D
-
Q
V
L
V
K
K
E
I
S
I
L
N
I
A
R
H
R
N
I
L
H
L
H
E
S
F
E
S
M
E
E
--
L
V
M
I
F
E
F
I
S
G
L
D
I
F
E
R
I
N
T
S
A
F
E
----
L
N
E
R
E
I
V
S
Y
V
H
Q
V
C
E
A
L
Q
F
L
H
S
H
N
-----
I
G
H
F
D
I
R
P
E
N
I
I
Y
Q
--
T
RR
S
---
S
T
I
K
I
I
E
F
G
Q
A
R
Q
L
K
P
---
G
D
N
F
R
L
L
F
T
A
P
E
Y
Y
A
P
E
V
H
Q
---
H
D
V
-
V
S
T
A
T
D
M
W
S
L
G
T
L
V
Y
V
L
L
S
G
I
N
P
F
L
A
E
T
N
Q
Q
I
I
E
N
I
M
N
A
E
Y
---
T
--
F
D
E
E
A
FK
E
I
S
I
E
A
M
D
F
V
D
R
L
L
V
K
E
R
K
S
R
M
T
A
S
E
A
L
Q
H
P
W
L
K
Q
K
I
E
R
V
S
T
K
V
I
R
T
L
K
H
R
R
Y
Y
H
T
L
I
K
K
D
L
------------------
N
M
V
V
S
A
A
R
I
S
C
G
G
A
I
R
S
Q
K
G
V
-------------------------------------------------------------------
S
V
A
K
V
K
V
A
S
I
-------
39
HHSearch
59.28
28%
-88
- C1 -
-
5J5T
1
M4K3_HUMAN
A:
[3-269]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
D
F
E
L
I
Q
R
I
G
S
G
T
Y
G
D
V
Y
K
A
R
N
V
N
T
G
E
L
A
A
I
K
V
I
K
L
E
P
-----
G
E
D
-
F
A
V
V
Q
Q
E
I
I
M
M
K
D
C
K
H
P
N
I
V
A
Y
F
G
S
Y
L
R
R
D
K
--
L
W
I
C
M
E
F
C
G
G
G
S
L
Q
D
I
Y
H
V
T
G
-----
P
L
S
E
L
Q
I
A
Y
V
S
R
E
T
L
Q
G
L
Y
Y
L
H
S
K
G
-----
K
M
H
R
D
I
K
G
A
N
I
L
L
T
--
D
--
N
---
G
H
V
K
L
A
D
F
G
V
S
A
Q
I
T
A
T
I
--
A
---
A
F
I
G
T
P
Y
W
M
A
P
E
V
A
A
V
ER
K
G
G
-
Y
N
Q
L
C
D
L
W
A
V
G
I
T
A
I
E
L
A
E
L
Q
P
P
M
F
D
L
H
P
M
R
A
L
F
L
M
T
K
S
N
F
Q
P
P
K
--
L
K
D
K
M
--
K
W
S
N
S
F
H
H
F
V
K
M
A
L
T
K
N
P
K
K
R
P
T
A
E
K
L
L
Q
H
P
F
V
T
Q
H
L
----------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
58.60
33%
-33
- C1 -
-
2XKD
1
NEK2_HUMAN
A:
[8-273]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
V
L
Y
T
I
G
T
G
---
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
T
---
E
A
E
-
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
-
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
---------
D
L
K
P
A
N
V
F
L
D
--
G
--
K
---
Q
N
V
K
L
G
D
F
----------------
T
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
---
R
M
S
-
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
F
---
R
---
R
I
P
Y
--
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
58.54
33%
-36
- C1 -
-
2XKF
1
NEK2_HUMAN
A:
[8-273]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
V
L
Y
T
I
G
T
G
---
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
T
---
E
A
E
-
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
-
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
--------
R
D
L
K
P
A
N
V
F
L
D
--
G
--
K
---
Q
N
V
K
L
G
D
F
-----------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
---
R
-
S
-
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
F
---
R
---
R
I
P
Y
--
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
58.45
33%
-45
- C1 -
-
2XNP
6
NEK2_HUMAN
A:
[8-273]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
V
L
Y
T
I
G
T
G
-
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
T
---
E
A
E
-
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
-
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
-------
H
R
D
L
K
P
A
N
V
F
L
D
--
G
--
K
---
Q
N
V
K
L
G
D
F
G
L
---------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
---
R
----
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
F
---
R
---
R
I
P
Y
--
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
58.02
33%
-42
- C1 -
-
2XNO
13
NEK2_HUMAN
A:
[8-273]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
V
L
Y
T
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
T
---
E
A
E
-
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
-
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
--------
R
D
L
K
P
A
N
V
F
L
D
--
G
--
K
---
Q
N
V
K
L
G
D
F
-----------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
---
R
----
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
F
---
R
---
R
I
P
Y
--
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
57.96
33%
-39
- C1 -
-
2XK4
1
NEK2_HUMAN
A:
[8-273]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
V
L
Y
T
I
G
T
--
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
T
---
E
A
E
-
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
-
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
--------
R
D
L
K
P
A
N
V
F
L
D
--
G
--
K
---
Q
N
V
K
L
G
D
F
G
L
---------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
---
R
M
---
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
F
---
R
---
R
I
P
Y
--
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
56.67
33%
-41
- C1 -
-
2XK7
1
NEK2_HUMAN
A:
[8-273]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
V
L
Y
T
I
G
T
G
---
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
T
---
E
A
E
-
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
-
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
--------
R
D
L
K
P
A
N
V
F
L
D
--
G
--
K
---
Q
N
V
K
L
G
D
F
------------------
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
--------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
F
---
R
---
R
I
P
Y
--
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
------------------------------------------------------------------------------------------------------------------------------------------------------
49
Fugue
56.56
20%
-46
- C1 -
-
1KOB
1
?
A:
[23-374]
----------------------------------------------------------------------------------------------------------------------------------------
I
N
D
Y
D
K
F
Y
E
D
I
W
K
K
Y
V
P
Q
P
V
-
E
V
K
Q
G
S
V
Y
D
Y
Y
D
I
L
E
E
L
G
S
G
A
F
G
V
V
H
R
C
V
E
K
A
T
G
R
V
F
V
A
K
F
I
N
T
P
--
Y
---
P
L
D
-
K
Y
T
V
K
N
E
I
S
I
M
N
Q
L
H
H
P
K
L
I
N
L
H
D
A
F
E
D
K
Y
E
--
M
V
L
I
L
E
F
L
S
G
G
E
L
F
D
R
I
A
A
E
D
Y
K
----
M
S
E
A
E
V
I
N
Y
M
R
Q
A
C
E
G
L
K
H
M
H
E
H
S
-----
I
V
H
L
D
I
K
P
E
N
I
M
C
E
TK
K
--
A
---
S
S
V
K
I
I
D
F
G
L
A
T
K
L
N
P
---
D
E
I
V
K
V
T
T
A
T
A
E
F
A
A
P
E
I
V
D
---
R
E
P
-
V
G
F
Y
T
D
M
W
A
I
G
V
L
G
Y
V
L
L
S
G
L
S
P
F
A
G
E
D
D
L
E
T
L
Q
N
V
K
R
C
D
W
---
E
--
F
D
E
D
A
FS
S
V
S
P
E
A
K
D
F
I
K
N
L
L
Q
K
E
P
R
K
R
L
T
V
H
D
A
L
E
H
P
W
L
K
G
---------
D
H
S
N
L
T
S
R
I
P
S
S
R
Y
N
K
I
R
Q
K
I
K
E
K
Y
A
D
W
P
A
P
Q
P
A
I
G
R
I
A
N
F
S
---------------------------------------------------------------------------
S
L
R
K
H
R
P
Q
E
Y
Q
I
Y
D
S
Y
F
D
R
K
E
A
--
15
PsiBlast_PDB
56.03
33%
-37
- C1 -
-
2XNN
7
NEK2_HUMAN
A:
[8-273]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
V
L
Y
T
I
G
T
--
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
T
---
E
A
E
-
K
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
-
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
--------
R
D
L
K
P
A
N
V
F
L
D
--
G
--
K
---
Q
N
V
K
L
G
D
F
G
----------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
---
R
---
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
F
---
R
---
R
I
P
Y
--
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
------------------------------------------------------------------------------------------------------------------------------------------------------
42
HHSearch
55.40
28%
-36
- C1 -
-
3C0G
1
CSKP_HUMAN
B:
[22-293]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
S
SP
G
L
S
-
T
E
D
L
K
R
E
A
S
I
C
H
M
L
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
--
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
A
-
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
-----
I
I
H
R
D
V
K
P
H
C
V
L
L
A
--
S
--
K
ENS
A
P
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
S
--
G
L
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
---
R
E
P
-
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
K
E
R
-
L
F
E
G
I
I
K
G
K
Y
---
K
MN
P
R
Q
W
S
--
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
-----------------------------------------------------------------------------------------------------------------------------------------------------