@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_34_0030: (2018-03-12 )
MGNYFSLCPEPFHGLISSYGIGSTSSTHPSGVAVKGQEYSAVKLVGEGGYSFVYEGYNNASGQRVALKRYVFSETQQQQGAVEEMSIYRDVCPNDYIVTYLDSEVVYRHGVPLPEMWVVMEFCDGPSLQEYINNRLRSPQPFSVREVFEIVDNIVHAIGHLHSQSPPVSHWDIKPENFLFTDTGRLKLCDFGSATRQFYAPTSAEEVSAAESELGSRMTLLYRPPESLDLWSKDRVDTKADIWALGVIIYVLVFREMPFDANPMEVMAAVPKRYKGKTQEGCPEEFRALMDIVRTKMLTKKPADRADIFAISEELEGITHLPPLSRPRPGFQSAQRPRFA
Atome Classification :
(20 SA)
.........10........20........30........40........50..--......60........70........80........90.-....-...100.......--110.......120.......130..-.....140...-....150.......160.......170.......180--.--......190.......200---.......210.......220....--...230.......240.......250......-.-260......----.---270--.........280.....---..290.......300.......310..--.....320.......330.......340---------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MGNYFSLC
P
E
P
F
H
G
L
I
S
SYGIGSTSSTHPS
G
V
A
V
KGQE
Y
S
A
V
K
L
V
GEGG
Y
S
F
V
--
Y
EGYNNASGQ
R
V
A
L
K
R
Y
V
F
S
E
T
Q
Q
QQG
A
V
E
E
M
S
I
Y
R
D
VC-PN
D
Y
-
I
V
T
Y
LDS
E
V
V
Y
RH--GVP
L
P
E
M
W
V
V
M
EFCDGP
S
L
Q
E
Y
I
N
N
-RLRSPQPF
S
V
R
-
E
V
F
E
I
V
D
N
I
V
H
A
I
G
H
L
HSQSPPVSHWDIKPE
N
F
L
FTD--T--G
R
L
K
L
CDFGS
A
T
R
Q
FYAPT---
S
A
E
E
V
S
A
A
E
S
E
LGS
R
M
T
L
L
YRPPE--SLDLWSKDRVDT
K
A
D
I
W
A
L
G
V
I
I
Y
V
L
V
F
R
EMP-F-DA
N
P
M
E
V
M
A
----
A
---
V
----
P
K
RYKGKTQEG
C
P
E
E
F
R
---
A
L
M
D
I
V
R
T
K
M
LTKKPADRA
D
I
F
A
I
S
E
E
--LEGITHLPPLSRPRPGFQSAQRPRFA-----------------------------------------
26
HHSearch
95.25
31%
-129
- C1 -
-
5TE0
10
AAK1_HUMAN
A:
[11-291]
----------------------------
G
R
V
F
G
I
G
R
Q
Q
V
T
V
D
E
V
L
A
E
G
G
F
A
I
V
--
F
L
V
R
T
S
-
N
G
M
K
C
A
L
K
R
M
F
V
N
N
E
H
D
L
Q
V
C
K
R
E
I
Q
I
M
R
D
L
S
-
G
H
K
N
-
I
V
G
Y
I
D
S
S
I
N
N
V
------
V
W
E
V
L
I
L
M
D
F
C
R
G
G
Q
V
V
N
L
M
N
Q
-
R
L
Q
--
T
G
F
T
E
N
-
E
V
L
Q
I
F
C
D
T
C
E
A
V
A
R
L
H
Q
C
K
T
P
I
I
H
R
D
L
K
V
E
N
I
L
L
H
D
--
R
--
G
H
Y
V
L
C
D
F
G
S
A
T
N
K
F
Q
N
P
Q
---
T
E
-
G
V
N
A
V
E
D
E
I
K
K
Y
T
T
L
S
Y
R
A
P
E
--
M
V
N
L
Y
S
G
K
I
I
T
T
K
A
D
I
W
A
L
G
C
L
L
Y
K
L
C
Y
F
T
L
P
-
F
-
G
E
S
Q
V
A
I
C
---------------
D
G
---
N
F
T
I
P
D
N
S
R
Y
S
---
Q
D
M
H
C
L
I
R
Y
M
L
E
P
D
P
D
K
R
P
D
I
Y
Q
V
S
Y
F
--
S
F
K
L
L
K
-------------------------------------------------------------
3
PsiBlast_PDB
91.21
31%
-114
- C1 -
-
4WSQ
1
AAK1_HUMAN
A:
[1-280]
-------------------
G
L
G
S
G
Y
I
G
R
V
F
G
I
G
--
R
Q
Q
V
T
V
D
E
V
L
A
E
G
G
F
A
I
V
--
F
L
-
V
R
T
S
N
G
M
K
C
A
L
K
R
M
F
V
N
N
E
H
D
L
Q
V
C
K
R
E
I
Q
I
M
R
D
L
S
-
G
H
K
N
-
I
V
G
Y
I
D
S
S
I
N
N
V
S
--
S
G
D
V
W
E
V
L
I
L
M
D
F
C
R
G
G
Q
V
V
N
L
M
N
Q
-
R
L
Q
T
G
--
F
T
E
N
-
E
V
L
Q
I
F
C
D
T
C
E
A
V
A
R
L
H
Q
C
K
T
P
I
I
H
R
D
L
K
V
E
N
I
L
L
H
D
--
R
--
G
H
Y
V
L
C
D
F
G
S
A
T
N
K
F
Q
N
P
Q
---
T
-
E
G
V
N
A
V
E
D
E
I
K
K
Y
T
T
L
S
Y
R
A
P
E
--
M
V
N
L
Y
S
G
K
I
I
T
T
K
A
D
I
W
A
L
G
C
L
L
Y
K
L
C
Y
F
T
L
P
-
F
-
G
E
S
Q
V
A
I
C
D
----
G
N
F
T
I
----
P
D
N
S
R
Y
S
Q
D
M
H
C
------------
L
I
R
Y
-
M
L
E
P
D
P
D
K
R
P
D
I
Y
Q
V
S
-----------------------------------------------------------------------
2
PsiBlast_PDB
86.96
32%
-113
- C1 -
-
5TE0
10
AAK1_HUMAN
A:
[19-283]
------------------------------------
Q
Q
V
T
V
D
E
V
L
A
E
G
G
F
A
I
V
--
F
L
-
V
R
T
S
N
G
M
K
C
A
L
K
R
M
F
V
N
N
E
H
D
L
Q
V
C
K
R
E
I
Q
I
M
R
D
L
S
-
G
H
K
N
-
I
V
G
Y
I
D
S
S
I
N
N
V
------
V
W
E
V
L
I
L
M
D
F
C
R
G
G
Q
V
V
N
L
M
N
Q
-
R
L
Q
T
G
--
F
T
E
N
-
E
V
L
Q
I
F
C
D
T
C
E
A
V
A
R
L
H
Q
C
K
T
P
I
I
H
R
D
L
K
V
E
N
I
L
L
H
D
--
R
--
G
H
Y
V
L
C
D
F
G
S
A
T
N
K
F
Q
N
P
Q
---
T
-
E
G
V
N
A
V
E
D
E
I
K
K
Y
T
T
L
S
Y
R
A
P
E
--
M
V
N
L
Y
S
G
K
I
I
T
T
K
A
D
I
W
A
L
G
C
L
L
Y
K
L
C
Y
F
T
L
P
-
F
-
G
E
S
Q
V
A
I
C
D
----
G
N
F
T
I
----
P
D
N
S
R
Y
S
Q
D
M
H
C
------------
L
I
R
Y
-
M
L
E
P
D
P
D
K
R
P
D
I
Y
Q
V
S
-----------------------------------------------------------------------
8
PsiBlast_PDB
86.12
31%
-113
- C1 -
-
5I3O
1
BMP2K_HUMAN
A:
[4-271]
--------------------------------
A
V
G
R
H
Q
V
T
L
E
E
S
L
A
E
G
G
F
S
T
V
--
F
L
-
V
R
T
H
G
G
I
R
C
A
L
K
R
M
Y
V
N
N
M
P
D
L
N
V
C
K
R
E
I
T
I
M
K
E
L
S
-
G
H
K
N
-
I
V
G
Y
L
D
C
-
A
V
N
S
I
--
S
D
N
V
W
E
V
L
I
L
M
E
Y
C
R
A
G
Q
V
V
N
Q
M
N
K
-
K
L
Q
T
G
--
F
T
E
P
-
E
V
L
Q
I
F
C
D
T
C
E
A
V
A
R
L
H
Q
C
K
T
P
I
I
H
R
D
L
K
V
E
N
I
L
L
N
D
--
G
--
G
N
Y
V
L
C
D
F
G
S
A
T
N
K
F
L
N
P
----
Q
K
D
G
V
N
V
V
E
E
E
I
K
K
Y
T
T
L
S
Y
R
A
P
E
--
M
I
N
L
Y
G
G
K
P
I
T
T
K
A
D
I
W
A
L
G
C
L
L
Y
K
L
C
F
F
T
L
P
-
F
-
G
E
S
Q
V
A
I
C
D
----
G
N
F
T
I
----
P
D
N
S
R
Y
S
R
N
I
H
C
L
I
R
F
-------------
M
L
E
P
D
P
E
H
R
P
D
I
F
Q
V
S
-----------------------------------------------------------------------
9
PsiBlast_PDB
84.76
31%
-110
- C1 -
-
5I3R
1
BMP2K_HUMAN
A:
[4-271]
--------------------------------
A
V
G
R
H
Q
V
T
L
E
E
S
L
A
E
G
G
F
S
T
V
--
F
L
-
V
R
T
H
G
G
I
R
C
A
L
K
R
M
Y
V
N
N
M
P
D
L
N
V
C
K
R
E
I
T
I
M
K
E
L
S
-
G
H
K
N
-
I
V
G
Y
L
D
C
-
A
V
N
S
I
--
S
D
N
V
W
E
V
L
I
L
M
E
Y
C
R
A
G
Q
V
V
N
Q
M
N
K
-
K
L
Q
T
G
--
F
T
E
P
-
E
V
L
Q
I
F
C
D
T
C
E
A
V
A
R
L
H
Q
C
K
T
P
I
I
H
R
D
L
K
V
E
N
I
L
L
N
D
--
G
--
G
N
Y
V
L
C
D
F
G
S
A
T
N
K
F
L
N
P
----
Q
K
D
G
V
N
V
V
E
E
E
I
K
K
Y
T
T
L
S
Y
R
A
P
E
--
M
I
N
L
Y
G
G
K
P
I
T
T
K
A
D
I
W
A
L
G
C
L
L
Y
K
L
C
F
F
T
L
P
-
F
-
G
E
S
Q
V
A
I
C
D
----
G
N
F
T
I
----
P
D
N
S
R
Y
S
R
N
I
H
C
L
I
R
F
-------------
M
L
E
P
D
P
E
H
R
P
D
I
F
Q
V
S
-----------------------------------------------------------------------
7
PsiBlast_PDB
84.01
31%
-111
- C1 -
-
5IKW
1
BMP2K_HUMAN
A:
[10-277]
--------------------------------
A
V
G
R
H
Q
V
T
L
E
E
S
L
A
E
G
G
F
S
T
V
--
F
L
-
V
R
T
H
G
G
I
R
C
A
L
K
R
M
Y
V
N
N
M
P
D
L
N
V
C
K
R
E
I
T
I
M
K
E
L
S
-
G
H
K
N
-
I
V
G
Y
L
D
C
-
A
V
N
S
I
--
S
D
N
V
W
E
V
L
I
L
M
E
Y
C
R
A
G
Q
V
V
N
Q
M
N
K
-
K
L
Q
T
G
--
F
T
E
P
-
E
V
L
Q
I
F
C
D
T
C
E
A
V
A
R
L
H
Q
C
K
T
P
I
I
H
R
D
L
K
V
E
N
I
L
L
N
D
--
G
--
G
N
Y
V
L
C
D
F
G
S
A
T
N
K
F
L
N
P
----
Q
K
D
G
V
N
V
V
E
E
E
I
K
K
Y
T
T
L
S
Y
R
A
P
E
--
M
I
N
L
Y
G
G
K
P
I
T
T
K
A
D
I
W
A
L
G
C
L
L
Y
K
L
C
F
F
T
L
P
-
F
-
G
E
S
Q
V
A
I
C
D
----
G
N
F
T
I
----
P
D
N
S
R
Y
S
R
N
I
H
C
L
I
R
F
-------------
M
L
E
P
D
P
E
H
R
P
D
I
F
Q
V
S
-----------------------------------------------------------------------
5
PsiBlast_PDB
83.95
31%
-114
- C1 -
-
4W9W
7
BMP2K_HUMAN
A:
[7-274]
--------------------------------
A
V
G
R
H
Q
V
T
L
E
E
S
L
A
E
G
G
F
S
T
V
--
F
L
-
V
R
T
H
G
G
I
R
C
A
L
K
R
M
Y
V
N
N
M
P
D
L
N
V
C
K
R
E
I
T
I
M
K
E
L
S
-
G
H
K
N
-
I
V
G
Y
L
D
C
-
A
V
N
S
I
--
S
D
N
V
W
E
V
L
I
L
M
E
Y
C
R
A
G
Q
V
V
N
Q
M
N
K
-
K
L
Q
T
G
--
F
T
E
P
-
E
V
L
Q
I
F
C
D
T
C
E
A
V
A
R
L
H
Q
C
K
T
P
I
I
H
R
D
L
K
V
E
N
I
L
L
N
D
--
G
--
G
N
Y
V
L
C
D
F
G
S
A
T
N
K
F
L
N
P
----
Q
K
D
G
V
N
V
V
E
E
E
I
K
K
Y
T
T
L
S
Y
R
A
P
E
--
M
I
N
L
Y
G
G
K
P
I
T
T
K
A
D
I
W
A
L
G
C
L
L
Y
K
L
C
F
F
T
L
P
-
F
-
G
E
S
Q
V
A
I
C
D
----
G
N
F
T
I
----
P
D
N
S
R
Y
S
R
N
I
H
C
L
I
R
F
-------------
M
L
E
P
D
P
E
H
R
P
D
I
F
Q
V
S
-----------------------------------------------------------------------
6
PsiBlast_PDB
83.15
31%
-114
- C1 -
-
4W9X
3
BMP2K_HUMAN
A:
[10-277]
--------------------------------
A
V
G
R
H
Q
V
T
L
E
E
S
L
A
E
G
G
F
S
T
V
--
F
L
-
V
R
T
H
G
G
I
R
C
A
L
K
R
M
Y
V
N
N
M
P
D
L
N
V
C
K
R
E
I
T
I
M
K
E
L
S
-
G
H
K
N
-
I
V
G
Y
L
D
C
-
A
V
N
S
I
--
S
---
W
E
V
L
I
L
M
E
Y
C
R
A
G
Q
V
V
N
Q
M
N
K
-
K
-
Q
T
G
--
F
T
E
P
-
E
V
L
Q
I
F
C
D
T
C
E
A
V
A
R
L
H
Q
C
K
T
P
I
I
H
R
D
L
K
V
E
N
I
L
L
N
D
--
G
--
G
N
Y
V
L
C
D
F
G
S
A
T
N
K
F
L
N
P
----
Q
K
D
G
V
N
V
V
E
E
E
I
K
K
Y
T
T
L
S
Y
R
A
P
E
--
M
I
N
L
Y
G
G
K
P
I
T
T
K
A
D
I
W
A
L
G
C
L
L
Y
K
L
C
F
F
T
L
P
-
F
-
G
E
S
Q
V
A
I
C
D
----
G
N
F
T
I
----
P
D
N
S
R
Y
S
R
N
I
H
C
L
I
R
F
-------------
M
L
E
P
D
P
E
H
R
P
D
I
F
Q
V
S
-----------------------------------------------------------------------
1
PsiBlast_PDB
81.69
32%
-112
- C1 -
-
5L4Q
2
AAK1_HUMAN
A:
[18-282]
------------------------------------
Q
Q
V
T
V
D
E
V
L
A
E
G
G
F
A
I
V
--
F
L
-
V
R
T
S
N
G
M
K
C
A
L
K
R
M
F
V
N
N
E
H
D
L
Q
V
C
K
R
E
I
Q
I
M
R
D
L
S
-
G
H
K
N
-
I
V
G
Y
I
D
S
S
I
N
N
V
S
--
S
G
D
V
W
E
V
L
I
L
M
D
F
C
R
G
G
Q
V
V
N
L
M
N
Q
-
R
L
Q
T
G
--
F
T
E
N
-
E
V
L
Q
I
F
C
D
T
C
E
A
V
A
R
L
H
Q
C
K
T
P
I
I
H
R
D
L
K
V
E
N
I
L
L
H
D
--
R
--
G
H
Y
V
L
C
D
F
G
S
A
T
N
K
F
Q
N
P
Q
---
T
-
E
G
V
N
A
V
E
D
E
I
K
K
Y
T
T
L
S
Y
R
A
P
E
--
M
V
N
L
Y
S
G
K
I
I
T
T
K
A
D
I
W
A
L
G
C
L
L
Y
K
L
C
Y
F
T
L
P
-
F
---------------NFT
I
----
P
D
N
S
R
Y
S
Q
D
M
H
C
------------
L
I
R
Y
-
M
L
E
P
D
P
D
K
R
P
D
I
Y
Q
V
S
-----------------------------------------------------------------------
4
PsiBlast_PDB
75.92
30%
-8
- C1 -
-
4C57
5
GAK_HUMAN
A:
[33-305]
------------------------------------------
R
V
L
A
E
G
G
F
A
F
V
--
Y
E
A
Q
D
V
G
S
G
R
E
Y
A
L
K
R
L
L
S
N
E
E
E
K
N
R
A
I
I
Q
E
V
C
F
M
K
K
L
S
-
G
H
P
N
-
I
V
Q
F
C
S
A
A
S
I
G
K
E
ES
D
T
G
Q
A
E
F
L
L
L
T
E
L
C
K
G
-
Q
L
V
E
F
L
K
--
K
M
E
S
R
G
P
L
S
C
D
-
T
V
L
K
I
F
Y
Q
T
C
R
A
V
Q
H
M
H
R
Q
K
P
P
I
I
H
R
D
L
K
V
E
N
L
L
L
S
N
--
Q
--
G
T
I
K
L
C
D
F
G
S
A
T
T
I
S
H
Y
P
D
YSW
S
A
Q
R
R
A
L
V
E
E
E
I
T
R
N
T
T
P
M
Y
R
T
P
E
--
I
I
D
L
Y
S
N
F
P
I
G
E
K
Q
D
I
W
A
L
G
C
I
L
Y
L
L
C
F
R
Q
H
P
-
F
-
E
D
G
A
K
--
L
R
----
I
---
V
----
N
G
K
Y
S
I
P
P
H
D
---
T
Q
Y
T
---
V
F
H
S
L
I
R
A
-
M
L
Q
V
N
P
E
E
R
L
S
I
A
E
V
V
H
Q
--
L
Q
E
I
---------------------------------------------------------------
31
HHSearch
73.22
22%
-127
- C1 -
-
2BUJ
2
STK16_HUMAN
A:
[19-310]
--------------------------
F
Q
G
H
M
V
I
I
D
N
K
H
Y
L
F
I
Q
K
L
G
E
--
F
S
Y
V
--
D
L
V
E
G
L
H
D
G
H
F
Y
A
L
K
R
I
L
C
H
E
Q
Q
D
R
E
E
A
Q
R
E
A
D
M
H
R
L
-
F
-
N
H
P
N
-
I
L
R
L
V
A
Y
C
L
R
E
R
----
G
A
K
H
E
A
W
L
L
L
P
F
F
K
R
G
T
L
W
N
E
I
E
R
-
L
K
D
K
G
N
F
L
T
E
D
-
Q
I
L
W
L
L
L
G
I
C
R
G
L
E
A
I
H
A
K
--
G
Y
A
H
R
D
L
K
P
T
N
I
L
L
G
D
--
E
--
G
Q
P
V
L
M
D
L
G
S
M
N
Q
A
C
I
H
V
E
---
G
S
R
Q
A
L
T
L
Q
D
W
A
A
Q
R
C
T
I
S
Y
R
A
P
E
--
L
F
S
V
Q
S
H
C
V
I
D
E
R
T
D
V
W
S
L
G
C
V
L
Y
A
M
M
F
G
E
G
P
-
Y
-
D
M
V
F
Q
K
G
D
S
--------
V
----
A
L
A
V
Q
N
Q
--
I
P
Q
S
P
R
H
S
---
S
A
L
W
Q
L
L
N
S
M
M
T
V
D
P
H
Q
R
P
H
I
P
L
L
L
S
Q
--
L
E
A
L
Q
P
P
A
P
G
---------------------------------------------------------
30
HHSearch
63.33
24%
-106
- C1 -
-
4XBR
1
INKA1_HUMAN (first)
A:
[94-352]
------------------------------------
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
--
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
Q
Q
R
R
E
L
L
F
N
E
V
V
I
M
R
D
-
Y
-
Q
H
E
N
-
V
V
E
M
Y
N
S
Y
L
--------
V
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
-
T
-----
R
M
N
E
E
-
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
--
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
--
D
--
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
P
------------
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
--
L
I
S
---
R
L
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
-
Y
-
F
N
E
P
P
L
K
A
M
----
K
---
M
----
I
R
D
N
L
-
P
P
R
L
K
N
L
H
K
V
S
---
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
--
P
F
L
A
K
A
G
P
-----------------------------------------------------------
44
Fugue
62.61
20%
-36
- C1 -
-
1KOB
1
?
A:
[23-374]
I
N
D
Y
D
K
F
Y
E
D
I
W
K
K
--------
Y
V
P
Q
P
V
E
V
K
Q
G
S
V
Y
D
Y
Y
D
I
L
E
E
L
G
S
G
A
F
G
V
V
--
H
R
C
V
E
K
A
T
G
R
V
F
V
A
K
F
I
N
T
P
Y
P
L
D
K
Y
T
V
K
N
E
I
S
I
M
N
Q
L
--
H
H
P
K
-
L
I
N
L
H
D
A
F
E
--------
D
K
Y
E
M
V
L
I
L
E
F
L
S
G
G
E
L
F
D
R
I
----
A
A
E
D
Y
K
M
S
E
A
-
E
V
I
N
Y
M
R
Q
A
C
E
G
L
K
H
M
H
E
H
S
--
I
V
H
L
D
I
K
P
E
N
I
M
C
E
T
--
K
KA
S
S
V
K
I
I
D
F
G
L
A
T
K
------------------
L
N
P
D
E
I
V
K
V
T
T
A
T
A
E
FA
A
P
E
I
V
D
R
E
P
V
G
F
Y
T
D
M
W
A
I
G
V
L
G
Y
V
L
L
S
G
L
S
P
-
F
A
G
E
D
D
L
E
T
L
Q
----
N
---
V
----
K
R
C
D
W
E
F
D
E
D
A
F
S
S
V
S
P
---
E
A
K
D
F
I
K
-
N
L
L
Q
K
E
P
R
K
R
L
T
V
H
D
A
L
E
H
PW
L
K
G
D
H
S
N
L
T
S
R
I
P
S
S
R
Y
N
K
I
R
Q
K
I
K
E
K
Y
ADWPAPQPAIGRIANFSSLRKHRPQEYQ
I
Y
D
S
Y
F
DRKEA
48
Fugue
62.47
22%
-59
- C1 -
-
1TKI
-
TITIN_HUMAN
A:
[18-338]
-----------------------------
K
E
L
---
Y
E
K
Y
M
I
A
E
D
L
G
R
G
E
F
G
I
V
--
H
R
C
V
E
T
S
S
K
K
T
Y
M
A
K
-
F
V
K
V
K
G
T
D
Q
V
L
V
K
K
E
I
S
I
L
N
I
A
--
R
H
R
N
-
I
L
H
------
L
H
E
S
--
F
E
S
M
E
E
L
V
M
I
F
E
F
I
S
G
L
D
I
F
E
R
I
N
T
-
S
---
A
F
E
L
N
E
R
-
E
I
V
S
Y
V
H
Q
V
C
E
A
L
Q
F
L
H
S
H
N
--
I
G
H
F
D
I
R
P
E
N
I
I
Y
Q
T
RR
S
--
S
T
I
K
I
I
E
F
G
Q
A
R
Q
------------------
L
K
P
G
D
N
F
R
L
L
F
T
A
P
E
YY
A
P
E
V
H
Q
H
D
V
V
S
T
A
T
D
M
W
S
L
G
T
L
V
Y
V
L
L
S
G
I
N
P
-
F
L
A
E
T
N
Q
Q
I
I
E
----
N
---
I
----
M
N
A
E
Y
T
F
D
E
E
A
F
K
E
I
S
I
---
E
A
M
D
F
V
D
-
R
L
L
V
K
E
R
K
S
R
M
T
A
S
E
A
L
Q
H
--
P
W
L
K
Q
K
I
E
R
V
S
T
K
V
I
R
T
L
K
H
R
R
Y
Y
H
T
L
IKKDLNMVVSAARISCGGAIRSQKG
V
S
V
A
K
V
K
V
A
SI----
17
PsiBlast_PDB
61.57
27%
-55
- C1 -
-
4FIF
1
PAK4_HUMAN
A:
[82-316]
--------------------------------------------
I
G
E
G
S
T
G
I
V
--
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
Q
Q
R
R
E
L
L
F
N
E
V
V
I
M
R
D
Y
Q
--
H
E
N
-
V
V
E
M
Y
N
S
Y
L
V
G
D
--------
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
T
R
M
N
E
E
Q
-------
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
--
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
--
D
--
G
R
V
K
L
S
D
F
G
------
F
C
A
Q
---
V
S
K
E
V
P
R
R
K
S
L
V
G
---
T
P
Y
W
M
A
P
E
-----
L
I
S
R
L
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
-
N
E
P
P
L
K
A
M
K
----
M
---
I
R
D
N
L
P
P
R
L
K
N
L
H
K
--
V
S
P
S
L
K
---
G
F
L
D
----
R
L
L
V
R
D
P
A
Q
R
A
-----------------------------------------------------------------------------
18
PsiBlast_PDB
61.32
27%
-52
- C1 -
-
4FIG
1
?
A:
[82-316]
--------------------------------------------
I
G
E
G
S
T
G
I
V
--
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
Q
Q
R
R
E
L
L
F
N
E
V
V
I
M
R
D
Y
Q
--
H
E
N
-
V
V
E
M
Y
N
S
Y
L
V
G
D
--------
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
T
R
M
N
E
E
Q
-------
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
--
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
--
D
--
G
R
V
K
L
S
D
F
G
------
F
C
A
Q
---
V
S
K
E
V
P
R
R
K
S
L
V
G
---
T
P
Y
W
M
A
P
E
-----
L
I
S
R
L
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
-
N
E
P
P
L
K
A
M
K
----
M
---
I
R
DNL
P
P
R
L
K
N
L
H
K
--
V
S
P
S
L
K
---
G
F
L
D
----
R
L
L
V
R
D
P
A
Q
R
A
-----------------------------------------------------------------------------
11
PsiBlast_PDB
61.10
27%
-54
- C1 -
-
2F57
1
PAK5_HUMAN
A:
[53-287]
--------------------------------------------
I
G
E
G
S
T
G
I
V
--
C
I
A
T
E
K
H
T
G
K
Q
V
A
V
K
K
M
D
L
R
K
Q
Q
R
R
E
L
L
F
N
E
V
V
I
M
R
D
Y
--
H
H
D
N
-
V
V
D
M
Y
S
S
Y
L
V
G
--------
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
T
R
M
N
E
E
Q
-------
I
A
T
V
C
L
S
V
L
R
A
L
S
Y
L
H
N
Q
G
--
V
I
H
R
D
I
K
S
D
S
I
L
L
T
S
--
D
--
G
R
I
K
L
S
D
F
G
------
F
C
A
Q
---
V
S
K
E
V
P
K
R
K
S
L
V
G
---
T
P
Y
W
M
A
P
E
--
V
I
---
S
R
L
P
Y
G
T
E
V
D
I
W
S
L
G
I
M
V
I
E
M
I
D
G
E
P
P
Y
F
-
N
E
P
P
L
Q
A
M
R
R
I
RD
S
---
L
----
P
P
R
V
K
D
L
H
K
--
V
S
S
V
L
R
---
G
F
L
D
L
----
M
L
V
R
E
P
S
Q
R
A
-----------------------------------------------------------------------------
14
PsiBlast_PDB
61.08
27%
-54
- C1 -
-
4FIE
1
PAK4_HUMAN
A:
[159-393]
--------------------------------------------
I
G
E
G
S
T
G
I
V
--
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
Q
Q
R
R
E
L
L
F
N
E
V
V
I
M
R
D
Y
Q
--
H
E
N
-
V
V
E
M
Y
N
S
Y
L
V
G
D
--------
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
T
R
M
N
E
E
Q
-------
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
--
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
--
D
--
G
R
V
K
L
S
D
F
G
------
F
C
A
Q
---
V
S
K
E
V
P
R
R
K
S
L
V
G
---
T
P
Y
W
M
A
P
E
-----
L
I
S
R
L
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
-
N
E
P
P
L
K
A
M
K
----
M
---
I
R
DNL
P
P
R
L
K
N
L
H
K
--
V
S
P
S
L
K
---
G
F
L
D
----
R
L
L
V
R
D
P
A
Q
R
A
-----------------------------------------------------------------------------
10
PsiBlast_PDB
60.88
26%
-2
- C1 -
-
2BUJ
2
STK16_HUMAN
A:
[24-310]
-------------------------------
V
I
I
D
N
K
H
Y
L
F
I
Q
K
L
G
E
--
F
S
Y
V
D
L
V
E
G
L
H
D
--
G
H
F
Y
A
L
K
R
I
L
C
H
E
Q
Q
D
R
E
E
A
Q
R
E
A
D
M
H
R
L
F
N
H
P
N
I
L
R
L
V
A
Y
C
L
R
E
R
G
A
K
H
-------
E
A
W
L
L
L
P
F
F
K
R
G
T
L
W
N
E
I
E
--
R
L
K
D
K
G
N
F
L
T
E
D
Q
I
L
W
L
L
L
G
I
C
R
G
L
E
A
I
H
A
K
G
--
Y
A
H
R
D
L
K
P
T
N
I
L
L
G
D
--
E
--
G
Q
P
V
L
M
D
L
G
S
M
N
Q
A
C
I
H
V
E
---
G
S
R
Q
A
L
T
L
Q
D
W
A
A
Q
R
C
T
I
S
Y
R
A
P
E
--
L
F
S
V
Q
S
H
C
V
I
D
E
R
T
D
V
W
S
L
G
C
V
L
Y
A
M
M
F
G
E
G
P
-
Y
-
D
---
M
V
F
Q
K
----
G
---
D
----
S
V
A
L
A
V
Q
N
Q
--
I
P
Q
S
P
R
HS
S
A
L
W
Q
L
L
N
S
-
M
M
T
V
D
P
H
Q
R
P
H
I
P
L
L
L
S
Q
--
L
E
A
------
L
Q
P
P
A
P
G
---------------------------------------------------
16
PsiBlast_PDB
59.82
27%
-57
- C1 -
-
4XBU
-
PAK4_HUMAN
A:
[327-561]
--------------------------------------------
I
G
E
G
S
T
G
I
V
--
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
Q
Q
R
R
E
L
L
F
N
E
V
V
I
M
R
D
Y
--
Q
H
E
N
-
V
V
E
M
Y
N
S
Y
L
V
G
D
--------
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
T
R
M
N
E
E
Q
-------
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
--
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
--
D
--
G
R
V
K
L
S
D
F
G
------
F
C
A
Q
---
V
S
K
E
V
P
R
R
K
S
L
V
G
---
T
P
Y
W
M
A
P
E
-----
L
I
S
R
L
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
-
N
E
P
P
L
K
A
M
K
----
M
---
I
R
DNL
P
P
R
L
K
N
L
H
K
--
V
S
P
S
L
K
---
G
F
L
D
----
R
L
L
V
R
D
P
A
Q
R
A
-----------------------------------------------------------------------------