@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_34_0990: (2018-03-12 )
MRAKIDDENSSVAVTLLPSAQVEPLASSQPPTRTGAVGTMVNTDAIDARGNDAESSGGGSAPSSMATTTTINAVFYNPSAQLPTPPPLHRNSSSPAPMQHLQHEEPQRLRAVPYFPASCESDSNEEPLFQHPPPAKPRAPLRPAPQSGRLWGAVSATPSSAGFVSGGTAPYASLLHTSSAPAVADTETSSTTAGHGLVVGCETSNHCLPASIKAHPPASATSPASIHGGYSDSVSDSTATTTVGNHSSGGRGLRRPPLMTGPNGAAVPLASPMLSGPQGRWVRSSGDESSSGFATLAVPAAPANLGDTVLVAEPPTPTKQRRTIHTGMGNTVSLSCGGIGAAPRLSTSAAASTGTCASAAAATSAAAVAGGASPKPSLRIAAPFRGLGYNPAANSVSAPASRATTSSMSTAPPPPSFKCYRREGSRKRSADVLSQFSALDLDETPATPFAQTGTSRFTSINHNGNGHNAFPSQPSPSTAVYRGAGGGSNAISTVSPLTIDYATPVALSQQIGGSNTFSQVLLHPSQDVLDMSQAETECSNFLARRILKEYNEVRLLGSGSFGTVSLFKEISSGEYVAVKMSPPLRTPEMERRYRRERSVMGMVRGLPHVVQLSAAWEEGRVPRMYLQLEYCPGGSVASVANAKQSRNEPWPEAEVKVFLAHMSIALDALHRANIAHVDFKPDNVLVDKDGAYKLSDFGCSVLLDERGRPRPETRNGYGSLARGQRAGWVGGVACANPNGGPAVHTGAGVGAGGLGSSLDFNNWNEGNELSTMSIDEGDCRYLCADMLNEKQHFKAGDMFSLGMSLFELMSGQPLPRNGDQFLALRRRVPVEVLRRRGYSADLVELVVALLRSDPPQRPTARQVLQYLRLSSEELQLLSSASAMKRWTESAESFLQLQEEERQQPPLGKDGVLAATVDALRCVSALMEASMWLFTTTQQDVHRLAAPANAGKGEDEEDERRRQQTQQPQPQPLLQLPRGQQLEDLPMSPIQCDEACTPTALNY
Atome Classification :
(30 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430...---....440.......450.......460.......470.......480.......490.......500.......510.--......520.......530.......-540..--...-------.----------.550.......560.......570.......580--.....-------...590-----.......600.......610.......620.......630.......640.......650.......660.......670-.......680....---..--.---690--.........700.......710.......720.......730.......740.......750.......760.......770.......780......------.790........800.......810...---...----------.--820-.---.---..----.----..-----.830.....-----...----.840.......850.....-----..860...--....870.......880.......890.......900.......910.....-..920.......930.......940.......950.......960.......970.......980.......990.......1000
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MRAKIDDENS
S
V
A
V
T
LLPSAQVEPLASSQPPTRTGA
V
G
T
M
V
NTDAIDARGNDAESSGGGSAPSS
M
A
T
T
T
T
I
N
A
V
F
YNPSAQLPTPPPLHRNSSSPA
P
M
Q
H
L
QHEEP
Q
R
LRAVPYFPASCESDSNEEPLFQHPPPAKPRAPLRPAPQSG
R
L
W
G
A
V
SATPSSAGFVSGGT
A
P
Y
A
S
L
LHTSSAP
A
V
ADTETSSTTAG
H
G
L
V
V
G
CETSNHCLPASIKAHPPASATSP
A
S
I
HGGYSDSVSDST
A
T
T
TVGNHSSGGRGLRRPPLMTGPNGAAVPLA
S
P
MLSGPQG
R
W
V
RSSGDESSS
G
F
A
T
L
AVPAAPANLG
D
T
V
L
V
AEPPTPTK
Q
R
R
T
I
HTGMG
N
T
V
S
L
SCGGIGAAPRLSTSAAASTGTCA
S
A
A
AAT
S
A
A
AVAGGASPKP
S
L
R
I
AAPFRGLGYNPAANSVSAPASRATTSSMSTAPPPPS
F
K
C
Y
RREGSRK
R
S
A
D
V
L
S
Q
---
F
SALDLDETPATPFAQTGTS
R
F
T
S
INHNGNGHNAFPSQPSPS
T
A
V
Y
RGAGGGSNA
I
S
TVS
P
L
T
I
DYATP
V
A
L
S
Q
QIGG--SN
T
F
S
Q
VLLHPS
Q
D
V
L
D
M
S
Q
A
E
T
E
C
S
-
N
F
L
A
R
--
R
I
L
-------
K
----------
E
YN
E
V
R
L
L
GSGSF
G
T
V
S
L
F
K
E
ISSG
E
Y
V
A
V
KM-S--PPLR
T
-------
P
E
M
E
R
R
-----
Y
R
R
E
R
S
V
M
G
M
V
RGL
P
H
V
V
Q
L
SAAWEEGRV
P
R
M
Y
L
Q
L
E
YCPGG
S
V
A
S
V
A
N
A
K
QSRNEPW
P
E
A
E
V
K
V
F
L
A
H
M
S
I
A
L
D
A
L
HRA-N
I
A
H
V
DFKPD
N
V
L
V---DK--D---G----
A
Y
K
LSDFG
C
S
V
L
LDERGRPRPETRNGYGSLARGQRAGWVG
G
V
A
CANPNGGPAVHTGAGVGAGGLGSSLDFNNWNEGNE
L
S
T
M
SIDEG
D
C
R
Y
L
C
A
D
M
LN------
E
K
Q
-HFKAG
D
M
F
S
L
G
M
S
L
F
E
L
MSGQPLP---RN
G
----------
D
--
Q
F
--
L
---
A
---
L
R
----
R
----RV-----
P
V
--
E
V
L
R
R-----RGY----
S
A
D
L
V
E
L
V
V
A
L
L
RSDPPQR-----
P
T
A
R
Q
V
L
Q
--
Y
L
RL
S
S
E
E
L
Q
L
L
S
S
A
S
A
M
K
R
W
T
E
S
A
E
S
F
L
Q
L
Q
E
E
ERQQPPLGKD
G
V
L
A
A
T
V
D
-
A
L
R
C
V
S
A
L
M
E
AS
M
W
L
F
TT
T
Q
Q
D
V
H
R
LAAPANAGKGE
D
E
E
D
E
R
R
R
Q
QTQQPQPQ
P
L
LQLPRGQQLEDLPMSPIQCDEACTPTALNY
52
Fugue
69.03
16%
6
- C1 -
-
3C4Z
1
RK_BOVIN
A:
[31-533]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
R
K
Y
L
A
R
L
K
L
P
P
L
S
K
C
E
A
L
R
E
S
L
D
L
G
F
E
G
M
C
L
E
Q
P
---
I
G
K
R
L
F
Q
Q
F
L
R
T
H
E
Q
H
G
P
A
L
Q
L
W
K
D
I
E
D
Y
D
T
A
D
D
A
L
R
P
Q
K
A
Q
A
L
R
A
A
Y
L
E
P
Q
A
Q
--
L
F
C
S
F
L
D
A
E
T
V
A
R
A
R
A
G
G
L
F
----
Q
P
L
L
R
A
V
L
A
H
L
G
Q
A
P
F
Q
E
F
L
D
S
L
Y
F
L
-
R
F
L
Q
W
--
K
W
L
E
A
QPMGE
D
----------
W
F
L
D
F
R
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
M
K
A
T
G
K
L
Y
A
C
K
K
-
L
N
K
K
R
L
K
K
-------
R
K
G
Y
Q
G
-----
A
M
V
E
K
K
I
L
A
K
V
H
S
-
R
F
I
V
S
L
A
Y
A
F
E
T
K
--
T
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
V
D
E
D
N
P
G
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
R
-
N
I
I
Y
R
D
L
K
P
E
N
V
L
L
---
D
D
--
D
---
G
----
N
V
R
I
S
D
L
G
L
A
V
E
L
K
A
-
G
Q
T
K
T
K
G
Y
A
G
T
P
G
-------------------------------------------------------------
F
M
A
P
E
L
L
L
------
G
E
E
-
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
R
G
P
F
---
R
A
R
G
E
K
V
------
E
--
N
K
--
E
---
L
---
K
Q
----
R
----
V
L
-----
E
Q
--
A
V
T
Y
P
-----
D
K
F
----
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
-----
L
G
F
R
D
-
G
S
--
C
D
G
L
R
T
H
P
L
F
R
D
I
S
W
R
Q
L
E
A
G
M
L
T
P
P
F
V
P
D
S
R
T
V
Y
A
K
N
G
A
F
S
G
V
A
F
E
K
A
D
T
E
-
F
F
Q
E
F
A
S
G
T
C
P
I
P
W
Q
E
E
M
I
E
T
G
V
F
G
D
L
N
V
W
R
P
-----------------------------------------------------
33
HHSearch
67.94
24%
-86
- C1 -
-
4XBR
1
INKA1_HUMAN (first)
A:
[93-350]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
-------
S
----------
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
-
M
--
D
L
R
K
--------
Q
Q
R
R
E
L
-----
L
F
N
E
V
V
I
M
R
D
Y
Q
-
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
--
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
T
-----
R
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
-
G
V
I
H
R
D
I
K
S
D
S
I
L
L
---
T
H
--
D
---
G
----
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
P
--------------------------------------------------------------
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
------
R
L
P
-
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
---
F
N
E
----------
P
--
P
L
--
K
A
M
K
M
---
I
R
----
D
----
N
L
-----
P
P
--
R
L
K
N
L
-----
H
K
V
----
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
-----
A
T
A
A
E
L
L
K
--
H
P
F
L
A
K
A
-----------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
65.36
25%
-86
- C1 -
-
5K00
1
MELK_HUMAN
A:
[6-265]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
-------
K
----------
Y
Y
E
L
H
E
T
I
G
T
G
--
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
-
M
--
D
K
N
T
L
-------
G
S
D
L
P
R
-----
I
K
T
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
--
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
----
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
-
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
--
Y
---
H
----
K
L
K
L
I
D
F
G
L
C
A
K
P
--------------------------------------------------------------------------
S
L
A
Y
A
A
P
E
L
I
Q
------
G
K
S
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
---
D
D
D
----------
N
--
V
---
M
---
A
---
L
Y
----
K
----
K
I
M
----
R
G
--
K
Y
D
V
P
-----
K
W
L
----
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
-----
I
S
M
K
N
L
L
N
--
H
P
W
I
M
Q
D
-----------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
64.32
28%
-2
- C1 -
-
2Y7J
1
PHKG2_HUMAN
C:
[93-364]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-------
Q
----------
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
-
M
--
E
V
T
A
E
RLSPEQL
E
E
V
R
E
A
-----
T
R
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
--
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
----
V
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
-
N
I
V
H
R
D
L
K
P
E
N
I
L
L
---
D
D
--
N
---
M
----
Q
I
R
L
S
D
F
G
F
S
C
H
L
E
P
G
E
K
---------------------------------------------------------------
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
CSMDET
H
P
G
-
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
---
W
H
R
----------
R
--
Q
I
--
L
---
M
---
L
R
MIME
G
----
Q
Y
-----
Q
F
--
S
S
P
E
W
-----
D
D
R
----
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
-----
L
T
A
E
Q
A
L
Q
--
H
P
F
F
E
-------------------------------------------------------------------------------------------------------------------------------------
44
HHSearch
63.82
23%
-67
- C1 -
-
4IDV
1
M3K14_HUMAN
A:
[73-328]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-------
H
----------
W
A
T
H
Q
L
R
L
G
R
G
S
F
G
E
V
H
R
M
E
D
K
Q
T
G
F
Q
C
A
V
K
K
-
V
--
R
L
E
V
-------------
F
-----
R
A
E
E
L
M
A
C
A
G
L
T
-
S
P
R
I
V
P
L
Y
G
A
V
R
E
G
P
--
W
V
N
I
F
M
E
L
L
E
G
G
S
L
G
Q
L
V
K
E
Q
----
G
C
L
P
E
D
R
A
L
Y
Y
L
G
Q
A
L
E
G
L
E
Y
L
H
S
R
-
R
I
L
H
G
D
V
K
A
D
N
V
L
L
---
S
S
--
D
---
G
S---
H
A
A
L
C
D
F
G
H
A
V
C
L
Q
P
D
G
L
G
K
S
---------------------------------------------------------
L
L
T
G
D
Y
I
P
G
T
E
T
H
M
A
P
E
V
V
L
------
G
R
S
-
C
D
A
K
V
D
V
W
S
S
C
C
M
M
L
H
M
L
N
G
C
H
P
W
---
T
Q
F
----------
F
--
R
G
--
P
---
L
C
L
K
I
A
----
S
----
E
P
-----
P
P
--
V
R
E
I
P
-----
P
S
C
----
A
P
L
T
A
Q
A
I
Q
E
G
L
R
K
E
P
I
H
R
-----
V
S
A
A
E
L
G
G
--
K
V
N
---------------------------------------------------------------------------------------------------------------------------------------
51
Fugue
63.07
17%
31
- C1 -
-
2ACX
1
GRK6_HUMAN
A:
[14-532]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
R
K
G
K
S
K
K
W
R
Q
M
L
Q
F
P
H
I
S
Q
C
E
E
L
R
L
S
L
E
R
D
Y
H
S
L
C
E
R
N
P
I
G
R
L
L
F
R
E
F
C
A
T
R
P
E
L
S
R
C
V
A
F
L
D
G
V
A
E
Y
E
V
T
P
D
D
K
R
K
A
C
G
R
N
L
T
Q
N
F
L
S
H
T
G
P
D
L
I
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L
E
Q
G
P
C
K
D
LF
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
-
R
F
L
Q
W
--
K
W
L
E
R
QPVTK
N
----------
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
R
A
T
G
K
M
Y
A
C
K
K
-
L
E
K
K
R
I
K
K
-------
R
K
G
E
A
M
-----
A
L
N
E
K
Q
I
L
E
K
V
N
S
-
R
F
V
V
S
L
A
Y
A
Y
E
T
K
--
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
--
H
M
G
Q
A
G
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
E
-
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
---
D
D
--
H
---
G
----
H
I
R
I
S
D
L
G
L
A
V
H
V
P
E
G
Q
T
I
K
G
R
V
---------------------------------------------------------------
G
T
V
G
Y
M
A
P
E
V
V
K
------
N
E
R
-
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
F
---
Q
Q
R
----------
K
--
K
K
--
I
---
K
----
R
----
E
----
E
V
-----
E
R
--
L
V
K
E
V
P
E
E
Y
S
E
R
F
----
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
LGCRG
G
S
A
R
E
V
K
E
--
H
P
L
F
K
K
L
N
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
D
P
Q
A
I
Y
C
E
P
T
D
Q
D
F
Y
Q
K
F
A
T
G
S
V
P
I
P
W
Q
N
-
E
M
V
E
T
E
C
F
Q
E
L
N
V
F
G
L
D
G
S
------------------------------------------------------------------
54
Fugue
62.77
23%
-42
- C1 -
-
5KCV
1
AKT1_HUMAN
A:
[20-452]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
K
E
G
W
L
H
K
R
G
E
Y
I
T
W
R
P
R
Y
F
L
L
K
N
D
G
T
-
F
I
G
Y
K
E
R
P
A
P
L
---------
N
N
F
S
V
A
Q
C
Q
L
M
K
T
E
R
P
R
P
N
T
F
I
I
R
C
L
Q
--
W
T
T
V
I
E
R
T
F
H
-----
V
E
T
P
E
E
R
E
E
W
T
-
T
A
I
Q
R
--
V
T
M
-------
N
----------
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
A
T
G
R
Y
Y
A
M
K
I
-
L
--
K
---------------
K
V
-----
L
Q
N
S
R
H
--------
P
F
L
T
A
L
K
Y
S
F
Q
T
H
--
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
----
L
F
F
H
L
S
R
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
---
D
K
--
D
---
G
----
H
I
K
I
T
D
F
G
---
L
C
P
E
---------------------------------------------------------------------------
Y
L
A
P
E
V
L
E
------
D
N
D
-
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
---
Y
N
Q
----------
D
--
H
E
--
K
---
L
---
F
E
----
L
----
I
L
-----
M
E
--
E
I
R
F
P
-----
R
T
L
----
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
LGGGS
E
D
A
K
E
I
M
Q
--
H
--------
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
------------------------------------------------------------------------------------------------
30
HHSearch
61.77
28%
2
- C1 -
-
2Y7J
1
PHKG2_HUMAN
D:
[93-364]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-------
Q
----------
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
-
M
--
E
V
---RLSPEQL
E
E
V
R
E
A
-----
T
R
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
--
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
----
V
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
-
N
I
V
H
R
D
L
K
P
E
N
I
L
L
---
D
D
--
N
---
M
----
Q
I
R
L
S
D
F
G
F
S
C
H
L
E
P
G
E
K
---------------------------------------------------------------
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
CSMDET
H
P
G
-
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
---
W
H
R
----------
R
--
Q
I
--
L
---
M
---
L
R
----
M
IMEG
Q
Y
-----
Q
F
--
S
S
P
E
W
-----
D
D
R
----
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
-----
L
T
A
E
Q
A
L
Q
--
H
P
F
F
E
-------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
59.53
23%
-13
- C1 -
-
3C0I
1
CSKP_HUMAN
A:
[23-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-------
D
----------
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
-
V
--
D
V
A
K
F
T
S
SP---
G
L
S
T
E
D
-----
L
K
R
E
A
S
I
C
H
M
L
K
-
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
--
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
-
N
I
I
H
R
D
V
K
P
H
C
V
L
L
---
A
S
--
K
---
E
NS
A
-
P
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
S
G
L
--------------------------------------------------------------
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
------
R
E
P
-
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
---
Y
G
T
----------
K
--
E
R
L
F
E
---
G
---
I
I
K
---
G
----
K
Y
-----
K
M
--
N
P
R
Q
W
-----
S
H
I
----
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
-----
I
T
V
Y
E
A
L
N
--
H
P
W
L
K
E
R
-----------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
58.54
23%
-14
* C1 *
-
3C0G
1
CSKP_HUMAN
B:
[23-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-------
D
----------
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
-
V
--
D
V
A
K
F
T
S
SP---
G
L
S
T
E
D
-----
L
K
R
E
A
S
I
C
H
M
L
K
-
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
--
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
-
N
I
I
H
R
D
V
K
P
H
C
V
L
L
---
A
S
--
K
ENS
A
----
P
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
S
G
L
--------------------------------------------------------------
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
------
R
E
P
-
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
---
Y
G
T
----------
K
--
E
R
L
F
E
---
G
---
I
I
K
---
G
----
K
Y
-----
K
M
--
N
P
R
Q
W
-----
S
H
I
----
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
-----
I
T
V
Y
E
A
L
N
--
H
P
W
L
K
E
R
-----------------------------------------------------------------------------------------------------------------------------------
53
Fugue
58.04
21%
11
- C1 -
-
4XHG
2
?
A:
[2-397]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
--
R
V
G
-------
R
----------
K
F
R
I
G
R
K
I
G
S
G
S
F
G
D
I
Y
H
G
T
N
L
I
S
G
E
E
V
A
I
R
L
E
S
--
I
R
S
R
H
-------
P
Q
L
D
Y
E
-----
S
R
V
Y
K
Y
L
S
G
G
V
-
G
I
P
F
I
R
W
F
G
---
R
E
G
E
Y
N
A
M
V
I
D
L
---
L
G
P
S
L
E
D
L
F
N
Y
---
C
H
R
K
F
S
F
K
T
V
I
M
L
A
L
Q
M
I
C
R
V
Q
Y
I
H
G
R
-
S
F
I
H
R
D
I
K
P
D
N
F
L
M
G
V
G
R
R
--
G
---
S
----
T
V
H
V
I
D
F
G
---------------------
L
S
K
K
Y
R
----------
D
F
N
T
H
R
H
I
------------------
P
Y
R
E
N
K
S
L
T
------
G
T
A
R
Y
A
S
V
N
T
H
L
------
G
I
E
-
Q
S
R
R
D
D
L
E
S
L
G
Y
M
L
I
Y
F
C
K
G
-
S
L
P
---
W
Q
G
LKATT
K
K
Q
K
Y
D
--
R
I
--
L
---
E
---
K
K
----
L
----
C
I
-----
S
V
--
E
T
L
C
A
------
G
L
----
P
L
E
F
S
E
Y
M
N
Y
C
R
N
L
K
F
D
E
R
-----
P
D
----
Y
L
--
Y
L
A
R
L
F
K
D
L
S
I
K
L
E
Y
H
N
D
H
L
F
D
W
T
M
L
R
Y
T
K
A
M
V
E
K
K
N
D
S
F
N
K
V
K
L
L
A
M
K
K
F
A
-
S
H
F
H
Y
C
K
N
D
D
K
H
Y
P
T
P
E
E
I
K
Q
Q
T
V
Q
N
N
N
A
A
P
E
L
L
S
A
I
D
K
----------------------------------------------
42
HHSearch
57.18
23%
-71
- C1 -
-
4G3F
1
A:
[57-312]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-------
H
----------
W
M
T
H
Q
P
R
V
G
R
G
S
F
G
E
V
H
R
M
K
D
K
Q
T
G
F
Q
C
A
V
K
K
-
V
--
R
L
E
-------------
V
F
-----
R
V
E
E
L
V
A
C
A
G
L
S
-
S
P
R
I
V
P
L
Y
G
A
V
R
E
G
P
--
W
V
N
I
F
M
E
L
L
E
G
G
S
L
G
Q
L
I
K
Q
M
----
G
C
L
P
E
D
R
A
L
Y
Y
L
G
Q
A
L
E
G
L
E
Y
L
H
T
R
-
R
I
L
H
G
D
V
K
A
D
N
V
L
L
---
S
S
--
D
---
G
S---
R
A
A
L
C
D
F
G
H
A
L
C
L
---------------------------------------------------------------------
D
Y
I
P
G
T
E
T
H
M
A
P
E
V
V
M
------
G
K
P
-
C
D
A
K
V
D
I
W
S
S
C
C
M
M
L
H
M
L
N
G
C
H
P
W
---
T
Q
Y
----------
F
--
R
G
--
P
L
C
L
K
---
I
A
----
S
----
E
P
-----
P
P
--
I
R
E
I
P
-----
P
S
C
----
A
P
L
T
A
Q
A
I
Q
E
G
L
R
K
E
P
V
H
R
-----
A
S
A
M
E
L
R
R
--
K
V
G
---------------------------------------------------------------------------------------------------------------------------------------
41
HHSearch
57.14
19%
-66
- C1 -
-
3CBL
3
A:
[113-370]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
-------
E
----------
D
L
V
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
R
A
D
N
T
L
V
A
V
K
S
-
C
--
R
E
T
L
P
-------
P
D
L
K
A
K
-----
F
L
Q
E
A
R
I
L
K
Q
Y
S
-
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
Q
--
P
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
E
---
G
A
R
L
R
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
-
C
C
I
H
R
D
L
A
A
R
N
C
L
V
---
T
E
--
K
---
N
----
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
V
Y
A
------------------------------------------------------------
A
S
G
G
L
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
------
Y
G
R
-
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
---
Y
P
N
----------
L
--
S
N
--
Q
---
Q
---
T
R
----
E
----
F
V
-----
E
K
G
G
R
L
P
C
P
-----
E
L
C
----
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
-----
P
S
F
S
T
I
Y
Q
--
E
L
Q
---------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
56.79
19%
-63
- C1 -
-
3BKB
7
A:
[113-370]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
-------
E
----------
D
L
V
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
R
A
D
N
T
L
V
A
V
K
S
-
C
--
R
E
T
L
P
-------
P
D
L
K
A
K
-----
F
L
Q
E
A
R
I
L
K
Q
Y
S
-
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
Q
--
P
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
E
---
G
A
R
L
R
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
-
C
C
I
H
R
D
L
A
A
R
N
C
L
V
---
T
E
--
K
---
N
----
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
V
Y
A
------------------------------------------------------------
A
S
G
G
L
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
------
Y
G
R
-
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
---
Y
P
N
----------
L
--
S
N
--
Q
---
Q
---
T
R
----
E
----
F
V
-----
E
K
G
G
R
L
P
C
P
-----
E
L
C
----
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
-----
P
S
F
S
T
I
Y
Q
--
E
L
Q
---------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
55.27
24%
-66
- C1 -
-
2X4F
4
MYLK4_HUMAN
A:
[89-349]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
----------
T
V
S
K
T
E
I
L
G
-----
Q
V
H
K
C
E
E
T
A
T
G
L
K
L
A
A
K
I
-
I
--
K
T
R
G
M
--------
K
D
K
E
E
-----
V
K
N
E
I
S
V
M
N
Q
L
D
-
H
A
N
L
I
Q
L
Y
D
A
F
E
S
K
N
--
D
I
V
L
V
M
E
Y
V
D
G
G
E
L
F
D
R
I
I
D
E
S
---
Y
N
L
T
E
L
D
T
I
L
F
M
K
Q
I
C
E
G
I
R
H
M
H
Q
M
-
Y
I
L
H
L
D
L
K
P
E
N
I
L
C
VN-
R
D
--
A
---
K
----
Q
I
K
I
I
D
F
G
L
A
R
R
Y
K
P
R
E
K
---------------------------------------------------------------
L
K
V
N
F
G
T
P
E
F
L
A
P
E
V
V
N
------
Y
D
F
-
V
S
F
P
T
D
M
W
S
V
G
V
I
A
Y
M
L
L
S
G
L
S
P
F
---
L
G
D
----------
N
--
D
A
--
E
---
T
---
L
N
----
N
I
L
A
C
R
W
-----
D
L
--
E
D
E
E
F
-----
Q
D
I
----
S
E
E
A
K
E
F
I
S
K
L
L
I
K
E
K
S
W
R
-----
I
S
A
S
E
A
L
K
--
H
P
W
L
S
D
H
-----------------------------------------------------------------------------------------------------------------------------------
48
Fugue
51.76
18%
6
- C1 -
-
1KOB
1
?
A:
[23-374]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
N
D
Y
D
K
F
Y
E
D
I
W
K
K
Y
V
P
Q
P
V
E
V
K
Q
G
--
S
V
Y
-------
D
----------
Y
Y
D
I
L
E
E
L
G
S
G
A
F
G
V
V
H
R
C
V
E
K
A
T
G
R
V
F
V
A
K
F
-
I
--
N
-
T
P
Y
-------
P
L
D
K
Y
T
-----
V
K
N
E
I
S
I
M
N
Q
L
H
H
-
P
K
L
I
N
L
H
D
A
F
E
D
K
--
Y
E
M
V
L
I
L
E
F
L
S
G
G
E
L
F
D
R
I
A
---
A
E
D
Y
K
M
S
E
A
E
V
I
N
Y
M
R
Q
A
C
E
G
L
K
H
M
H
E
H
-
S
I
V
H
L
D
I
K
P
E
N
I
M
C
ET-
K
K
--
A
---
S
----
S
V
K
I
I
D
F
G
L
A
T
K
L
N
P
D
E
I
---------------------------------------------------------------
V
K
V
T
T
A
T
A
E
F
A
A
P
E
I
V
D
------
R
E
P
-
V
G
F
Y
T
D
M
W
A
I
G
V
L
G
Y
V
L
L
S
G
L
S
P
F
---
A
G
E
----------
D
--
D
L
--
E
---
T
---
L
Q
----
N
----
V
K
-----
R
C
--
D
W
E
F
D
-----
E
D
A
FSSV
S
P
E
A
K
D
F
I
K
N
L
L
Q
K
E
P
R
K
R
-----
L
T
V
H
D
A
L
E
--
H
P
W
L
K
G
D
-------
H
S
N
L
T
S
R
I
P
S
S
R
Y
N
K
I
R
Q
K
I
K
E
K
Y
A
D
W
P
A
P
Q
P
A
I
G
R
I
A
-
N
F
S
S
L
R
K
H
R
P
Q
E
Y
Q
I
Y
D
S
Y
F
D
R
K
E
A
------------------------------------------------------------
26
HHSearch
51.54
21%
-58
- C1 -
-
1TKI
-
TITIN_HUMAN
A:
[20-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Y
-------
E
----------
K
Y
M
I
A
E
D
L
G
R
G
E
F
G
I
V
H
R
C
V
E
T
S
S
K
K
T
Y
M
A
K
F
-
V
--
K
V
K
G
---------
T
D
Q
V
L
-----
V
K
K
E
I
S
I
L
N
I
A
R
-
H
R
N
I
L
H
L
H
E
S
F
E
S
M
E
--
E
L
V
M
I
F
E
F
I
S
G
L
D
I
F
E
R
I
N
T
S
---
A
F
E
L
N
E
R
E
I
V
S
Y
V
H
Q
V
C
E
A
L
Q
F
L
H
S
H
-
N
I
G
H
F
D
I
R
P
E
N
I
I
Y
---
Q
T
RR
S
---
S
----
T
I
K
I
I
E
F
G
Q
A
R
Q
L
K
P
G
D
N
---------------------------------------------------------------
F
R
L
L
F
T
A
P
E
Y
Y
A
P
E
V
H
Q
------
H
D
V
-
V
S
T
A
T
D
M
W
S
L
G
T
L
V
Y
V
L
L
S
G
I
N
P
F
---
L
A
E
----------
T
--
N
Q
--
Q
---
I
---
I
E
----
N
I
M
N
A
E
Y
-----
T
F
--
D
E
E
A
F
-----
K
E
I
----
S
I
E
A
M
D
F
V
D
R
L
L
V
K
E
R
K
S
R
-----
M
T
A
S
E
A
L
Q
--
H
P
W
L
K
Q
K
-----------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
50.86
22%
-49
- C1 -
-
4NIF
-
KS6A1_HUMAN
A:
[6-269]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
-------
D
----------
G
Y
V
V
K
E
T
I
G
V
G
S
Y
S
E
C
K
R
C
V
H
K
A
T
N
M
E
Y
A
V
K
V
-
I
--
D
K
S
K
------------
R
D
-----
P
S
E
E
I
E
I
L
L
R
Y
G
Q
H
P
N
I
I
T
L
K
D
V
Y
D
D
G
K
--
H
V
Y
L
V
T
E
L
M
R
G
G
E
L
L
D
K
I
L
R
Q
----
K
F
F
S
E
R
E
A
S
F
V
L
H
T
I
G
K
T
V
E
Y
L
H
S
Q
-
G
V
V
H
R
D
L
K
P
S
N
I
L
Y
---
V
D
--
E
---
S
GNPE
C
L
R
I
C
D
F
G
F
A
K
Q
L
R
A
E
N
G
--------------------------------------------------------------
L
L
M
T
P
C
Y
---
F
V
A
P
E
V
L
K
------
R
Q
G
-
Y
D
E
G
C
D
I
W
S
L
G
I
L
L
Y
T
M
L
A
G
Y
T
P
F
---
A
N
G
----------
P
SD
T
P
--
E
---
E
---
I
L
----
T
----
R
I
G
S
GKF
T
L
--
S
G
G
N
W
-----
N
T
V
----
S
E
T
A
K
D
L
V
S
K
M
L
H
V
D
P
H
Q
R
-----
L
T
A
K
Q
V
L
Q
--
H
P
W
V
T
Q
------------------------------------------------------------------------------------------------------------------------------------
49
Fugue
50.42
18%
-33
- C1 -
-
1TKI
-
TITIN_HUMAN
A:
[18-338]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
E
L
Y
-------
E
----------
K
Y
M
I
A
E
D
L
G
R
G
E
F
G
I
V
H
R
C
V
E
T
S
S
K
K
T
Y
M
A
K
F
-
V
--
K
--
V
K
-------
G
T
D
Q
V
L
-----
V
K
K
E
I
S
I
L
N
I
A
R
H
-
R
N
I
L
H
L
H
E
S
F
E
S
M
--
E
E
L
V
M
I
F
E
F
I
S
G
L
D
I
F
E
R
I
N
T
S
---
A
F
E
L
N
E
R
E
I
V
S
Y
V
H
Q
V
C
E
A
L
Q
F
L
H
S
H
-
N
I
G
H
F
D
I
R
P
E
N
I
I
Y
QT-
R
R
--
S
---
S
----
T
I
K
I
I
E
F
G
Q
A
R
Q
L
K
P
G
---------------------------------------------------------------
D
N
F
R
L
L
F
T
A
P
E
Y
Y
A
P
E
V
H
Q
------
H
D
V
-
V
S
T
A
T
D
M
W
S
L
G
T
L
V
Y
V
L
L
S
G
I
N
P
F
---
L
A
E
----------
T
--
N
Q
--
Q
---
I
---
I
E
----
N
----
I
M
N
AEY-
T
F
--
D
E
E
A
F
-----
K
E
I
----
S
I
E
A
M
D
F
V
D
R
L
L
V
K
E
R
K
S
R
-----
M
T
A
S
E
A
L
Q
--
H
P
W
L
K
Q
K
I
E
R
V
S
T
K
V
------
I
R
T
L
K
H
R
R
Y
Y
H
T
L
I
K
K
D
L
N
M
V
V
S
A
A
R
I
S
C
G
G
-
A
I
R
S
Q
K
G
V
S
V
A
K
V
K
V
A
S
I
-------------------------------------------------------------------
47
Fugue
47.12
18%
-28
- C1 -
-
2RIO
1
IRE1_YEAST
A:
[8-434]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
F
E
Q
--
S
L
K
-------
N
----------
L
V
V
S
E
K
I
L
G
Y
G
S
S
G
T
-
V
V
F
Q
G
S
F
Q
G
R
P
V
A
V
K
R
-
M
--
L
-----------
I
D
F
C
D
I
-----
A
L
M
E
I
K
L
L
T
E
S
D
D
H
P
N
V
I
R
Y
Y
C
S
E
T
T
D
R
--
F
L
Y
I
A
L
E
L
C
N
L
N
L
Q
D
L
V
E
S
----------
K
Y
N
P
I
S
L
L
R
Q
I
A
S
G
V
A
H
L
H
S
L
-
K
I
I
H
R
D
L
K
P
Q
N
I
L
V
---
S
T
--
S
----------------------
S
R
F
T
A
D
Q
Q
T
G
A
E
N
L
R
I
L
I
---
S
D
F
------------------------
G
L
C
K
K
L
D
S
T
S
G
W
R
A
P
E
L
L
E
E
S
N
N
L
Q
----------
T
------
K
R
R
-
L
T
R
S
I
D
I
F
S
M
G
C
V
F
Y
Y
I
L
S
K
G
K
H
P
FGD
K
Y
S
----------
R
--
E
S
--
N
---
I
---
I
R
----
G
----
I
F
-----
S
L
--
D
E
M
K
C
LHD--
R
S
L
----
I
A
E
A
T
D
L
I
S
Q
M
I
D
H
D
P
L
K
R
-----
P
T
A
M
K
V
L
R
HP
L
F
W
P
K
S
K
K
L
E
F
L
L
K
V
S
D
R
L
E
I
E
N
R
D
P
P
S
A
L
L
M
K
F
D
A
G
S
D
F
V
I
P
S
G
D
W
T
V
K
F
D
K
T
F
M
D
R
K
Y
H
S
S
K
L
M
D
L
L
R
A
L
R
N
K
Y
H
H
F
M
D
L
P
E
D
I
A
E
L
M
G
P
V
P
D
G
F
Y
D
Y
F
T
K
R
F
-
P
N
L
L
I
G
V
Y
M
I
V
K
E
N
L
S
D
D
Q
I
L
R
E
F
L
Y
S
-----
16
PsiBlast_PDB
41.96
33%
-53
- C1 -
-
4YVC
1
ROCK1_HUMAN
A:
[74-243]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
----------
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
S
T
R
K
V
Y
A
M
K
L
------
L
S
K
-------
F
E
M
I
K
-F----
F
W
E
E
R
D
I
M
A
F
A
N
S
-
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
--
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
-----
N
Y
D
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
M
-
G
F
I
H
R
D
V
K
P
D
N
M
L
L
---
D
K
--
S
---
G
----
H
L
K
L
A
D
F
G
T
C
M
K
M
N
K
E
G
M
V
R
C
D
T
A
V
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
40.53
31%
10
- C1 -
-
4L6Q
1
ROCK2_HUMAN
A:
[24-240]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
I
N
V
E
S
L
L
D
G
--
L
N
S
L
V
L
D
L
D
F
P
A
L
------
R
K
N
K
N
I
D
-
N
F
L
N
R
Y
E
K
I
V
-------
K
K
I
R
G
L
QMKAE
D
Y
D
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
A
S
Q
K
V
Y
A
M
K
L
------
L
S
K
-------
F
E
M
I
K
R
SDSAF
F
W
E
E
R
D
I
M
A
F
A
N
S
-
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
--
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
-----
N
Y
D
V
P
E
K
W
A
K
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
M
-
G
L
I
H
R
D
V
K
P
D
N
M
L
L
---
D
K
--
H
---
G
----
H
L
K
L
A
D
F
G
T
C
M
K
M
D
E
T
G
M
V
H
C
D
T
A
V
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
35.73
30%
14
- C1 -
-
2F2U
1
ROCK2_BOVIN
A:
[12-242]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
R
K
L
E
A
L
I
R
D
P
R
S
P
I
N
V
E
S
L
L
D
G
--
L
N
S
L
V
L
D
L
D
F
P
A
L
------
R
K
N
K
N
I
D
-
N
F
L
N
R
Y
E
K
I
V
-------
K
K
I
R
G
L
QMKAE
D
Y
D
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
A
S
Q
K
V
Y
A
M
K
L
------
L
S
K
-------
F
E
M
I
K
R
SDSAF
F
W
E
E
R
D
I
M
A
F
A
N
S
-
P
W
V
V
Q
L
F
C
A
F
Q
D
D
K
Y
--
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
-----
N
Y
D
V
P
E
K
W
A
K
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
M
-
G
L
I
H
R
D
V
K
P
D
N
M
L
L
---
D
K
--
H
---
G
----
H
L
K
L
A
D
F
G
T
C
M
K
M
D
E
T
G
M
V
H
C
D
T
A
V
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
35.49
33%
-1
- C1 -
-
2ETR
1
ROCK1_HUMAN
A:
[74-236]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
----------
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
S
T
R
K
V
Y
A
M
K
L
------
L
S
K
-------
F
E
M
I
K
R
SDSAF
F
W
E
E
R
D
I
M
A
F
A
N
S
-
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
--
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
-----
N
Y
D
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
M
-
G
F
I
H
R
D
V
K
P
D
N
M
L
L
---
D
K
--
S
---
G
----
H
L
K
L
A
D
F
G
T
C
M
K
M
N
K
E
G
M
V
R
C
D
T
A
V
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
35.35
30%
9
- C1 -
-
2H9V
1
ROCK2_BOVIN
A:
[10-247]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
Q
R
K
L
E
A
L
I
R
D
P
R
S
P
I
N
V
E
S
L
L
D
G
--
L
N
S
L
V
L
D
L
D
F
P
A
L
------
R
K
N
K
N
I
D
-
N
F
L
N
R
Y
E
K
I
V
-------
K
K
I
R
G
L
QMKAE
D
Y
D
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
A
S
Q
K
V
Y
A
M
K
L
------
L
S
K
-------
F
E
M
I
K
R
SDSAF
F
W
E
E
R
D
I
M
A
F
A
N
S
-
P
W
V
V
Q
L
F
C
A
F
Q
D
D
K
Y
--
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
-----
N
Y
D
V
P
E
K
W
A
K
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
M
-
G
L
I
H
R
D
V
K
P
D
N
M
L
L
---
D
K
--
H
---
G
----
H
L
K
L
A
D
F
G
T
C
M
K
M
D
E
T
G
M
V
H
C
D
T
A
V
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
34.66
33%
-1
- C1 -
-
5KKS
1
ROCK1_HUMAN
A:
[74-241]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
----------
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
S
T
R
K
V
Y
A
M
K
L
------
L
S
K
-------
F
E
M
I
K
R
SDSAF
F
W
E
E
R
D
I
M
A
F
A
N
S
-
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
--
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
-----
N
Y
D
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
M
-
G
F
I
H
R
D
V
K
P
D
N
M
L
L
---
D
K
--
S
---
G
----
H
L
K
L
A
D
F
G
T
C
M
K
M
N
K
E
G
M
V
R
C
D
T
A
V
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
34.05
33%
2
- C1 -
-
2ETK
1
ROCK1_HUMAN
A:
[74-236]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
----------
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
S
T
R
K
V
Y
A
M
K
L
------
L
S
K
-------
F
E
M
I
K
R
SDSAF
F
W
E
E
R
D
I
M
A
F
A
N
S
-
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
--
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
-----
N
Y
D
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
M
-
G
F
I
H
R
D
V
K
P
D
N
M
L
L
---
D
K
--
S
---
G
----
H
L
K
L
A
D
F
G
T
C
M
K
M
N
K
E
G
M
V
R
C
D
T
A
V
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
33.92
33%
-2
- C1 -
-
4YVE
1
ROCK1_HUMAN
A:
[74-246]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
----------
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
S
T
R
K
V
Y
A
M
K
L
------
L
S
K
-------
F
E
M
I
K
R
SDSAF
F
W
E
E
R
D
I
M
A
F
A
N
S
-
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
--
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
-----
N
Y
D
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
M
-
G
F
I
H
R
D
V
K
P
D
N
M
L
L
---
D
K
--
S
---
G
----
H
L
K
L
A
D
F
G
T
C
M
K
M
N
K
E
G
M
V
R
C
D
T
A
V
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
33.25
33%
-2
- C1 -
-
5BML
1
ROCK1_HUMAN
A:
[74-243]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
----------
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
S
T
R
K
V
Y
A
M
K
L
------
L
S
K
-------
F
E
M
I
K
R
SDSA
F
F
W
E
E
R
D
I
M
A
F
A
N
S
-
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
--
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
-----
N
Y
D
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
M
-
G
F
I
H
R
D
V
K
P
D
N
M
L
L
---
D
K
--
S
---
G
----
H
L
K
L
A
D
F
G
T
C
M
K
M
N
K
E
G
M
V
R
C
D
T
A
V
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
32.66
33%
2
- C1 -
-
3D9V
1
ROCK1_HUMAN
A:
[74-236]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
----------
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
S
T
R
K
V
Y
A
M
K
L
------
L
S
K
-------
F
E
M
I
K
R
SDSAF
F
W
E
E
R
D
I
M
A
F
A
N
S
-
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
--
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
-----
N
Y
D
V
P
E
K
W
A
R
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
M
-
G
F
I
H
R
D
V
K
P
D
N
M
L
L
---
D
K
--
S
---
G
----
H
L
K
L
A
D
F
G
T
C
M
K
M
N
K
E
G
M
V
R
C
D
T
A
V
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------