@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_34_1840: (2018-03-12 )
MPPKLKPLPAKKSTLPPELPEESDELTVGNIRVGPRGVEFTGEGDLQVRRPDLNFENLKRVRQLGQGTQGNVSMYVTADKSVFAVKKITIPVTLDTRTRQTVAAELRNIFSAQSNEYTVNLYNAFYRNRALRLVMEYMDWGNIDELIAEKVKIPPTVCGYIASQMLHALAVLHTKSNIVTEPNQHKSLRQIHRDIKPANVLLSTTGCVKLADFGIATSAETIGVNSFVGTATYMSPERIQGRRYSTPSDIWSVGVVVAQMLLGHYPFSSVSKGFMALLREINSVEKYPLMDETGCSQETQDFIDSCLRQDPDDRSSAFELLESPWIKYCEEHGKAEMVALLASLGDRNRQYREDDALQAASRETSSLSLPRDTSETCKADNPLGM
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260....----------------.---..270.......280..--.....290.......300.......310.......320.......330.......340.......350.......360.......370.......380...
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MPPKLKPLPAKKSTLPPELPEESDE
L
T
V
G
N
I
R
VGPRG
V
E
FTGEG
D
L
Q
V
RRPDL
N
F
E
N
L
K
R
V
R
Q
LGQGTQG
N
V
S
M
Y
V
TADK
S
V
F
A
V
K
K
I
T
I
P
V
T
LDTR
T
R
Q
T
V
A
A
E
L
R
N
I
F
SAQSN
E
Y
T
V
N
L
Y
N
A
F
Y
R
N
R
A
L
R
L
V
M
E
Y
MDWG
N
I
D
E
L
I
A
E
KVKIP
P
T
V
C
G
Y
I
A
S
Q
M
L
H
A
L
A
V
L
HTKSNIVTEP
N
Q
H
K
S
L
R
Q
I
H
R
DIKPA
N
V
L
L
STTG
C
V
K
L
ADFGIATS
A
E
T
I
GVNSFVGTATYM
S
P
E
RIQGRRYS
T
P
S
D
I
W
S
V
G
V
V
V
A
Q
M
L
LGHY
P
----------------
F
---
S
S
V
S
K
G
F
M
A
L
L
R
E
I
N
S
V
--EKYPLMDETGC
S
Q
E
T
Q
D
F
I
D
S
C
L
RQDPD
D
R
S
S
A
F
E
L
L
E
S
P
W
I
K
Y
C
E
EHG
K
A
E
M
V
A
L
L
A
S
LGDRNRQYR
E
D
D
A
L
Q
A
ASRETSSLSLPRDTSETCKADNPLGM
2
PsiBlast_PDB
85.43
31%
-95
- C1 -
-
3ORN
3
MP2K1_HUMAN
A:
[2-270]
---------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
-
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
L
H
E
C
N
S
-
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
K
K
A
G
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
------------
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
N
S
F
V
G
T
R
S
Y
M
S
P
E
R
L
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
----------------
I
PPP------
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
G
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
----------------------------------------------------------
4
PsiBlast_PDB
85.35
31%
-100
- C1 -
-
3WIG
3
MP2K1_HUMAN
A:
[2-270]
---------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
----
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
L
H
E
C
N
S
-
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
K
K
A
G
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
------------
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
N
S
F
V
G
T
R
S
Y
M
S
P
E
R
L
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
----------------
I
PPP-----
P
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
G
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
----------------------------------------------------------
10
PsiBlast_PDB
83.73
28%
-101
- C1 -
-
3EQD
1
MP2K1_HUMAN
A:
[29-329]
---------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
-
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
L
H
E
C
N
S
-
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
K
K
A
G
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
------------
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
N
S
F
V
G
T
R
S
Y
M
S
P
E
R
L
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
IPPPD
A
K
E
L
E
L
M
F
GC-----------
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
G
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
----------------------------------------------------------
9
PsiBlast_PDB
83.55
28%
-103
- C1 -
-
3EQC
2
MP2K1_HUMAN
A:
[29-329]
---------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
-
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
L
H
E
C
N
S
-
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
K
K
A
G
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
------------
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
---
V
G
T
R
S
Y
M
S
P
E
R
L
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
IPPPD
A
K
E
L
E
L
M
F
GC-----------
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
G
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
----------------------------------------------------------
14
PsiBlast_PDB
83.54
28%
-99
- C1 -
-
3EQI
1
MP2K1_HUMAN
A:
[29-329]
---------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
-
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
L
H
E
C
N
S
-
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
K
K
A
G
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
------------
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
N
S
F
V
G
T
R
S
Y
M
S
P
E
R
L
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
IPPPD
A
K
E
L
E
L
M
FGC-----------
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
G
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
----------------------------------------------------------
8
PsiBlast_PDB
83.20
30%
-76
- C1 -
-
4ANB
2
MP2K1_HUMAN
A:
[5-263]
---------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
-
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
L
H
E
C
N
S
-
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
K
K
A
G
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
------------
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
E
M
A
N
E
F
V
G
T
R
S
Y
M
S
P
E
R
L
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
------------------------
R
P
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
A
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
----------------------------------------------------------
13
PsiBlast_PDB
82.87
28%
-101
- C1 -
-
3EQH
2
MP2K1_HUMAN
A:
[29-329]
---------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
-
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
L
H
E
C
N
S
-
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
K
K
A
G
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
------------
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
N
S
F
V
G
T
R
S
Y
M
S
P
E
R
L
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
IPPPD
A
K
E
L
E
L
M
F
GC-----------
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
G
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
----------------------------------------------------------
1
PsiBlast_PDB
82.57
32%
-85
- C1 -
-
3SLS
2
MP2K1_HUMAN
A:
[21-283]
---------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
-
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
L
H
E
C
N
S
-
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
K
K
A
G
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
------------
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
------
F
V
G
T
R
S
Y
M
S
P
E
R
L
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
----------------
I
---
G
-------
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
G
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
----------------------------------------------------------
11
PsiBlast_PDB
82.55
28%
-102
- C1 -
-
3EQF
1
MP2K1_HUMAN
A:
[29-329]
---------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
-
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
L
H
E
C
N
S
-
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
K
K
A
G
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
------------
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
N
S
F
V
G
T
R
S
Y
M
S
P
E
R
L
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
IPPPD
A
K
E
L
E
L
M
F
GC-----------
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
G
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
----------------------------------------------------------
3
PsiBlast_PDB
82.31
31%
-106
- C1 -
-
3OS3
2
MP2K1_HUMAN
A:
[2-270]
---------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
-
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
L
H
E
C
N
S
-
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
K
K
A
G
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
------------
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
N
S
F
V
G
T
R
S
Y
M
S
P
E
R
L
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
----------------
I
P---------
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
--
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
----------------------------------------------------------
12
PsiBlast_PDB
81.96
28%
-100
- C1 -
-
3EQG
2
MP2K1_HUMAN
A:
[29-329]
---------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
-
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
L
H
E
C
N
S
-
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
K
K
A
G
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
------------
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
N
S
F
V
G
T
R
S
Y
M
S
P
E
R
L
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
IPPPD
A
K
E
L
E
L
M
FGC-----------
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
G
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
----------------------------------------------------------
19
PsiBlast_PDB
81.35
27%
-107
- C1 -
-
4U7Z
2
MP2K1_HUMAN
A:
[2-302]
---------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
-
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
L
H
E
C
N
S
-
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
K
K
A
G
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
------------
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
N
S
-
V
G
T
R
S
Y
M
S
P
E
R
L
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
IPPPD
A
K
E
L
E
L
M
F------------
P
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
G
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
----------------------------------------------------------
5
PsiBlast_PDB
81.24
30%
-79
- C1 -
-
4AN2
2
MP2K1_HUMAN
A:
[5-263]
---------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
-
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
L
H
E
C
N
S
-
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
K
K
A
G
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
------------
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
E
M
A
N
E
F
V
G
T
R
S
Y
M
S
P
E
R
L
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
------------------------
R
P
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
A
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
----------------------------------------------------------
20
PsiBlast_PDB
80.84
27%
-109
- C1 -
-
4U80
2
MP2K1_HUMAN
A:
[2-302]
---------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
-
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
L
H
E
C
N
S
-
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
K
K
A
G
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
------------
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
---
V
G
T
R
S
Y
M
S
P
E
R
L
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
IPPPD
A
K
E
L
E
L
M
F------------
P
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
G
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
----------------------------------------------------------
7
PsiBlast_PDB
80.74
30%
-79
- C1 -
-
4AN9
2
MP2K1_HUMAN
A:
[5-263]
---------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
-
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
L
H
E
C
N
S
-
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
K
K
A
G
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
------------
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
E
M
A
N
E
-
V
G
T
R
S
Y
M
S
P
E
R
L
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
------------------------
R
P
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
A
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
----------------------------------------------------------
18
PsiBlast_PDB
80.32
27%
-111
- C1 -
-
3W8Q
1
MP2K1_HUMAN
A:
[24-324]
---------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
-
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
L
H
E
C
N
S
-
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
K
K
A
G
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
------------
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
N
S
F
V
G
T
R
S
Y
M
S
P
E
R
L
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
IPPPD
A
K
E
L
E
L
M
F
GCQ--------
R
P
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
G
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
----------------------------------------------------------
15
PsiBlast_PDB
80.28
28%
-92
- C1 -
-
5HZE
1
MP2K1_HUMAN
A:
[27-327]
---------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
-
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
L
H
E
C
N
S
-
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
K
K
A
G
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
----------------
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
N
S
F
V
G
T
R
S
Y
M
S
P
E
R
L
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
IPPPDAK
E
L
E
L
M
F-------------
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
G
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
----------------------------------------------------------
6
PsiBlast_PDB
79.86
30%
-79
- C1 -
-
4AN3
2
MP2K1_HUMAN
A:
[5-263]
---------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
-
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
L
H
E
C
N
S
-
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
K
K
A
G
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
------------
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
E
M
A
N
E
--
G
T
R
S
Y
M
S
P
E
R
L
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
------------------------
R
P
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
A
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
----------------------------------------------------------
16
PsiBlast_PDB
79.25
27%
-113
- C1 -
-
2Y4I
1
MP2K1_RABIT
C:
[64-364]
---------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
----
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
L
H
E
C
N
S
-
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
K
K
A
G
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
------------
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
N
S
F
V
G
T
R
S
Y
M
S
P
E
R
L
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
IPPPDAKELELMFGC-----------
P
M
A
I
F
E
L
L
D
Y
I
VN
E
P
P
P
K
L
P
S
A
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
----------------------------------------------------------
17
PsiBlast_PDB
77.51
27%
-111
- C1 -
-
5KKR
-
MP2K1_RABIT
C:
[64-364]
---------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
----
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
L
H
E
C
N
S
-
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
K
K
A
G
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
------------
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
S
M
A
N
S
F
V
G
T
R
S
Y
M
S
P
E
R
L
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
IPPPDAKELELMFGC-----------
P
M
A
I
F
E
L
L
D
Y
I
VN
E
P
P
P
K
L
P
S
A
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
----------------------------------------------------------