@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_34_1910: (2018-03-12 )
MPQDARLQPFSLVGIEATVRPEQRRWSAGKRSGTHGRPLERFFLFLFLAALALCSVCCSQASSAPFHPARHIVADEALSNAPSARSVALRYTFPGSSLALLVTEGGHLHAYDLERGQHAWCADAGGDMVTVTIDLPPSKEAALRDPLALPFLVRGNSLFTRVPFFTYTPLESMDATERLEGLPQSLRPYFFMNISTLLRRQTLFLGGTDVYVTTSVQVADLDASTGRPVGGLETPSQAFCGSNATRSPPRGDSTTESHRVPHNELLPLLHIVRYNIVLHVVRPGEYSWSICLSQLRMSPRAVVQPRFPSPFSAHSAADTSSAAPEDDSEHTPRFFSQFMRNMFDYDDEHVVNVAYRRAADQQANPTPAARTSTAVLMRNLQRTHTQAADYISRVVSVHQVNESHVSLRSVHDGTTAWTSALPHVAREPSGDGTGSTTSSSNATSTVIAAYVWVSGADEIFRVPVLRLAFGSVVEEAEQLRISMETDARGAVPTGLPRLTSASLAGALVPATHAAGRLQLWTLMQSGDSGRGRCRDGGACGEWATDDVEADEREETELAAYYHQCTWWETPPVSWPLLAGAFNGESGAVTFQAIDSATSSRTVAGTSGVYSTENPPLGFDSSGAVVKTGLAWRTAAFISFHVLCLAGSIAFLCAGVPPRGQLQRAWAQADRNRDRVSHTSSSHQPSTQLVPQDLLSPHGGRGTPFSLIMDSFSMDTLGLGTLPTASASMATVSLPHSDDSLQELMRHHQLGHLSRSPPRSPWVYPAPEQVRSLTYEESEKMLPVTATPATTTTTKGTATSSKAGFGMTPSTARQKAKTSETPVKRAAALPSSPADSAAADKAAASASNSSSDDDTVDIDLGERWWLRAQFLPRQHASAPALDETFSDRGSSYSRSQANTGTEEEGKLFQLHFKVLEKIGFGGEGSVFCVEHRVTHARYAIKVIHIHEKDEERVVQEAVLHSSFDNANVVRFYFCWIEDIAVSTANRLELCHRDEDGLDATSLAYSDNSLMVSTSGNTNGHSTDHDTASKAGDTYHMLFIQMEYFPRGTLADWLRLRSGFFRLEVLRYMKQIGEGLAYLHNQDVVHHDLKPTNIFVSNDNVLKIGDFGLAKRRGNANGSAGDLASNVAGGQEERSVVGGSPLYSSPEQTRGEPVNKPSDIFSLGIIAVEMLCTFTTLHERIRILTDAHQLILPEELEAEFPDEAQLIKSMLAANPLQRPPIRKLLRQISKLIVALEAQESDEEAEKPPPPSPLDGAEHSESRNGNDEAATVALVDDSASALAAATATGKFGNTPLSTSVTAASSSCGRSVAADLASGSHVDSFPSPLGEQKSRVALLPVLHSEAATGISAAAASHMPATTSAHDSNAASTGKHVTRLGDSLASLHASTMVKRGNTYHHRRRGSASPNMEAEIGRLHICEMVATGSASRKEFFANDPYGLPNTPVMYTEDADLSTILKHDLQDRTVSAPD
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940......--.950.......960.......970.......980....-...990.......1000......1010......1020......1030......1040......1050...-.--..1060--...-....1070......1080......1090.....-.1100......1110......1120......1130......1140......1150....-----...1160......1170.......1180........--1190......1200--.........1210......1220......1230......1240......1250......1260......1270......1280...---...1290......1300......1310......1320......1330......1340......1350......1360......1370......1380......1390......1400......1410......1420......1430......1440......1450......1460....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MPQDARLQ
P
F
S
L
V
G
I
E
A
TV
R
P
E
Q
R
RWSAGKRSGTHG
R
P
L
E
R
F
F
L
F
L
F
L
A
A
L
A
L
C
S
V
C
C
S
QASSAPFH
P
A
R
H
I
V
A
D
E
A
LSNAPSA
R
S
V
A
L
R
Y
TFPG
S
S
L
A
L
L
V
TEGG
H
L
H
A
Y
DLERGQH
A
W
CADAGG
D
M
V
T
V
T
I
DLPPSK
E
A
ALRDPLA
L
P
F
L
VRGNS
L
F
T
RV
P
F
F
T
YTPLESM
D
A
T
E
R
L
EG
L
P
Q
S
L
R
P
Y
F
F
M
N
I
S
T
L
L
R
R
Q
T
L
F
LGG
T
D
V
Y
V
T
T
S
V
Q
V
A
DLDASTGRPVGGLETP
S
Q
AFCGSNATRSPPRGDSTTESHRV
P
H
N
E
L
L
P
L
L
H
I
V
R
Y
N
I
V
L
H
V
VRPGE
Y
S
W
S
I
C
L
S
Q
LRMSPRAVVQPRFPSPFSAHSAADTSSAAPEDDSEH
T
P
R
F
F
S
Q
F
M
R
N
MFDYDD
E
H
V
V
N
V
A
Y
R
RAADQQANPTPAA
R
T
S
T
A
V
L
M
R
N
L
Q
R
T
H
T
Q
A
A
D
Y
I
S
R
V
V
S
V
H
QVNESH
V
S
L
R
SVHDG
T
T
A
W
T
S
ALP
H
V
AREPSGDGTGSTTSSSNAT
S
T
V
I
A
A
Y
V
W
VSGA
D
E
I
F
R
V
P
V
L
R
L
A
F
G
S
V
V
E
E
A
E
Q
L
R
I
S
METDARGAVPTGLPRL
T
S
A
S
LA
G
A
LVPATHAAGR
L
Q
L
W
T
L
MQSGDSGRGRCRDGGACGEWATDDVEA
D
E
R
E
E
T
E
L
A
A
Y
Y
H
QCTWWETPPVSW
P
L
L
A
G
AFNGESG
A
V
T
F
Q
AIDSATSSR
T
V
AGTSGVYSTENPPLGFDSSG
A
V
V
KTGL
A
W
R
T
A
A
F
I
S
F
H
V
L
C
L
A
G
S
I
A
F
L
CAGVPP
R
G
Q
L
Q
R
A
W
A
Q
ADRNRDRVSHTSSSHQPSTQLV
P
Q
D
LLSPHGGRGT
P
F
S
L
I
M
D
SFSMDTLGLGTLPTASA
S
M
A
T
V
SLPHS
D
D
S
L
Q
E
L
M
R
H
H
QLGHLSRSPPRSPWVYPA
P
E
Q
V
R
S
L
T
Y
E
ESEKM
L
P
V
TATPATTTTTKGTATSSKAGFGMT
P
S
T
A
RQKAKTSETP
V
K
R
A
AALPSSPADSAAADKAAASASNSSSDD
D
T
V
D
IDLG
E
R
W
W
L
R
AQFLPRQHASAPA
L
D
E
T
F
S
DRGSSYSRSQANTGTEEEGK
L
F
Q
L
H
F
K
V
L
E
K
IGFGGEG
S
V
F
C
V
EHRVTH
A
R
Y
A
I
K
V
I
H
I
HEK
D
--
E
E
R
V
V
Q
E
A
V
L
HSSFDNA
N
V
V
R
F
Y
F
C
W
I
E
D
I
A
V
S
T
A
N
R
L
-
E
L
CHRDEDGLDA
T
S
L
AYSD
N
S
L
M
V
S
TSGNTNGHSTDHDTASKAG
D
T
Y
H
M
L
F
I
Q
M
E
YFPR
G
T
L
A
D
W
L
R
L
R
S-G--
F
F
R
L
E
---
V
L
R
-
Y
M
K
Q
I
G
E
G
L
A
Y
LHNQDVVHHDLKP
T
N
I
F
VSND
N
-
V
L
K
IGDFGLAKRRGNANGSA
G
D
L
A
S
NVAGGQ
E
E
RSVVGGSPLYSSPEQTRGE-PVNK
P
S
-----
D
I
F
S
L
G
I
I
A
V
E
M
L
C
-
T
F
T
T
L
H
E
R
I
R
--
I
L
T
D
A
H
Q
LI--L
P
E
E
L
EAEFP
D
-----
E
A
Q
L
I
K
S
M
L
AANPLQR
P
P
I
R
K
L
L
R
Q
I
S
K
L
I
V
A
LEAQESDEEAEKPPPPSPLDGAEHSESRNGNDE
A
A
T
V
A
L
VDDSA
S
A
L
A
A
A
TATG---KFGNTPLS
T
S
V
TAASSSC
G
R
S
V
A
A
D
LASGSHVDSFPSP
L
G
EQKS
R
V
A
L
L
P
VLHSEAATG
I
S
A
A
AASHMPATTSAHDSNAASTG
K
H
V
T
R
L
G
D
S
L
A
S
L
H
A
S
T
M
V
KRGNT
Y
H
HRRRGSASPNMEAEIG
R
L
H
I
C
E
MVATGSAS
R
K
EFFANDPYGLPNT
P
V
M
Y
TEDA
D
L
S
T
I
L
K
H
D
LQDRTVSAPD
14
PsiBlast_PDB
74.23
30%
-65
- C1 -
-
1ZY5
1
GCN2_YEAST
A:
[8-282]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
E
I
A
V
L
G
Q
G
A
F
G
Q
V
V
K
A
R
N
A
L
D
S
R
Y
Y
A
I
K
K
I
R
H
T
E
E
K
--
L
S
T
I
L
S
E
V
M
L
L
A
S
L
N
H
Q
Y
V
V
R
Y
Y
A
A
W
L
E
-----------------------------------------
R
R
N
F
V
K
------
K
K
S
T
---
L
F
I
Q
M
E
Y
C
E
N
G
T
L
Y
D
L
I
H
S
E
N
L
N
--
Q
Q
R
D
E
---
Y
W
R
-
L
F
R
Q
I
L
E
A
L
S
Y
I
H
S
Q
G
I
I
H
R
D
L
K
P
M
N
I
F
I
D
E
S
R
-
N
V
K
I
G
D
F
G
L
A
K
---
N
V
H
R
----------------------
A
M
Y
V
A
T
E
V
L
D
G
T
G
H
Y
N
E
K
I
-----
D
M
Y
S
L
G
I
I
F
F
E
M
I
Y
-
P
F
S
T
G
M
E
R
V
N
--
I
L
K
K
L
R
S
V
S
--
I
--
E
F
P
P
D
F
D
D
NKM
K
V
E
K
K
I
I
R
L
L
I
D
H
D
P
N
K
R
P
G
A
R
T
L
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
73.62
30%
-65
- C1 -
-
1ZY4
1
GCN2_YEAST
A:
[8-282]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
E
I
A
V
L
G
Q
G
A
F
G
Q
V
V
K
A
R
N
A
L
D
S
R
Y
Y
A
I
K
K
I
R
H
T
E
E
K
--
L
S
T
I
L
S
E
V
M
L
L
A
S
L
N
H
Q
Y
V
V
R
Y
Y
A
A
W
L
E
-----------------------------------------
R
R
N
F
V
K
------
K
K
S
T
---
L
F
I
Q
M
E
Y
C
E
N
G
T
L
Y
D
L
I
H
S
E
N
L
N
--
Q
Q
R
D
E
---
Y
W
R
-
L
F
R
Q
I
L
E
A
L
S
Y
I
H
S
Q
G
I
I
H
R
D
L
K
P
M
N
I
F
I
D
E
S
R
-
N
V
K
I
G
D
F
G
L
A
K
---
N
V
H
R
----------------------
A
M
Y
V
A
T
E
V
L
D
G
T
G
H
Y
N
E
K
I
-----
D
M
Y
S
L
G
I
I
F
F
E
M
I
Y
-
P
F
S
T
G
M
E
R
V
N
--
I
L
K
K
L
R
S
V
S
--
I
--
E
F
P
P
D
F
D
D
NKM
K
V
E
K
K
I
I
R
L
L
I
D
H
D
P
N
K
R
P
G
A
R
T
L
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
Fugue
72.11
21%
-19
- C1 -
-
4AW2
5
MRCKA_RAT
A:
[1-416]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
E
V
R
L
R
Q
L
E
Q
F
I
L
D
G
P
A
Q
T
N
G
Q
C
F
S
V
E
T
L
L
D
I
L
I
C
L
Y
D
E
C
N
N
S
P
L
R
R
E
-
K
N
I
L
E
Y
L
E
W
A
K
P
F
T
S
K
V
K
Q
M
R
L
H
R
E
D
F
E
I
L
K
V
I
G
R
G
A
F
G
E
V
A
V
V
K
L
K
N
A
D
K
V
F
A
M
K
I
L
N
K
W
E
M
L
--
K
R
-------------------------
A
E
T
A
C
F
R
E
E
R
D
-
V
L
V
N
G
D
S
K
W
I
T
T
L
H
Y
A
F
Q
D
D
N
---------------------------
N
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F
E
-
D
--
R
L
P
E
E
---
M
A
R
F
Y
L
A
E
M
V
I
A
I
D
S
V
H
Q
L
H
Y
V
H
R
D
I
K
P
D
N
I
L
M
D
M
N
G
-
H
I
R
L
A
D
F
G
S
C
L
K
----------
L
M
E
D
---
G
T
V
Q
S
S
V
A
V
G
T
P
D
Y
I
S
P
E
I
L
Q
A
M
-
E
G
G
K
G
R
YGP
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
-
G
E
T
P
F
Y
A
E
S
----
L
V
E
T
Y
G
K
I
--
M
N
H
K
E
R
F
Q
F
P
T
-----
Q
V
T
D
V
----------
S
E
N
A
K
D
L
I
R
---
R
L
I
C
S
R
E
H
R
L
G
Q
N
G
I
E
D
F
K
K
H
P
F
F
S
G
I
D
W
D
N
I
R
N
C
--
E
A
P
Y
I
P
E
V
S
S
P
T
D
T
S
N
F
D
V
D
S
G
HHL
P
F
V
G
F
T
Y
T
S
S
C
V
L
S
D
R
S
C
L
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
69.35
29%
-58
- C1 -
-
1ZYC
-
GCN2_YEAST
A:
[599-976]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
E
I
A
V
L
G
Q
G
A
F
G
Q
V
V
K
A
R
N
A
L
D
S
R
Y
Y
A
I
K
K
I
R
H
T
E
E
K
--
L
S
T
I
L
S
E
V
M
L
L
A
S
L
N
H
Q
Y
V
V
R
Y
Y
A
A
W
L
E
-----------------------------------------
R
R
N
---------
K
K
S
T
---
L
F
I
Q
M
E
Y
C
E
N
R
T
L
Y
D
L
I
H
S
E
N
L
N
--
Q
Q
R
D
E
---
Y
W
R
-
L
F
R
Q
I
L
E
A
L
S
Y
I
H
S
Q
G
I
I
H
R
D
L
K
P
M
N
I
F
I
D
E
S
R
-
N
V
K
I
G
D
F
G
L
A
K
---
N
----------------------
I
G
T
A
M
Y
V
A
T
E
V
L
D
G
T
G
H
Y
N
E
K
I
-----
D
M
Y
S
L
G
I
I
F
F
E
M
I
Y
-
P
F
S
T
G
M
E
R
V
N
--
I
L
K
K
L
R
S
V
S
--
I
--
E
F
P
P
D
F
D
D
NKM
K
V
E
K
K
I
I
R
L
L
I
D
H
D
P
N
K
R
P
G
A
R
T
L
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
69.17
29%
-66
- C1 -
-
1ZYD
1
GCN2_YEAST
A:
[8-282]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
E
I
A
V
L
G
Q
G
A
F
G
Q
V
V
K
A
R
N
A
L
D
S
R
Y
Y
A
I
K
K
I
R
H
T
E
E
K
--
L
S
T
I
L
S
E
V
M
L
L
A
S
L
N
H
Q
Y
V
V
R
Y
Y
A
A
W
L
E
-----------------------------------------
R
R
N
F
V
K
------
K
K
S
T
---
L
F
I
Q
M
E
Y
C
E
N
R
T
L
Y
D
L
I
H
S
E
N
L
N
--
Q
Q
R
D
E
---
Y
W
R
-
L
F
R
Q
I
L
E
A
L
S
Y
I
H
S
Q
G
I
I
H
R
D
L
K
P
M
N
I
F
I
D
E
S
R
-
N
V
K
I
G
D
F
G
L
A
K
--------------------------
I
G
T
A
M
Y
V
A
T
E
V
L
D
G
T
G
H
Y
N
E
K
I
-----
D
M
Y
S
L
G
I
I
F
F
E
M
I
Y
-
P
F
S
T
G
M
E
R
V
N
--
I
L
K
K
L
R
S
V
S
--
I
--
E
F
P
P
D
F
D
D
NKM
K
V
E
K
K
I
I
R
L
L
I
D
H
D
P
N
K
R
P
G
A
R
T
L
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
68.56
28%
-63
- C1 -
-
1ZXE
1
GCN2_YEAST
A:
[8-282]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
E
I
A
V
L
G
Q
G
A
F
G
Q
V
V
K
A
R
N
A
L
D
S
R
Y
Y
A
I
K
K
I
R
H
T
E
E
K
--
L
S
T
I
L
S
E
V
M
L
L
A
S
L
N
H
Q
Y
V
V
R
Y
Y
A
A
W
L
E
-----------------------------------------
R
R
N
F
V
K
------
K
K
S
T
---
L
F
I
Q
M
E
Y
C
E
N
R
T
L
Y
D
L
I
H
S
E
N
L
N
--
Q
Q
R
D
E
---
Y
W
R
-
L
F
R
Q
I
L
E
A
L
S
Y
I
H
S
Q
G
I
I
H
R
N
L
K
P
M
N
I
F
I
D
E
S
R
-
N
V
K
I
G
D
F
G
L
A
K
---
N
---------------------
A
I
G
T
A
M
Y
V
A
T
E
V
L
D
G
--
H
Y
N
E
K
I
-----
D
M
Y
S
L
G
I
I
F
F
E
M
I
Y
-
P
F
S
T
G
M
E
R
V
N
--
I
L
K
K
L
R
S
V
S
--
I
--
E
F
P
P
D
F
D
D
NKM
K
V
E
K
K
I
I
R
L
L
I
D
H
D
P
N
K
R
P
G
A
R
T
L
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
63.94
28%
-39
- C1 -
-
4X7J
2
A:
[21-289]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
P
I
Q
C
L
G
R
G
G
F
G
V
V
F
E
A
K
N
K
V
D
D
C
N
Y
A
I
K
R
I
R
L
P
N
R
E
L
A
R
E
K
V
M
R
E
V
K
A
L
A
K
L
E
H
P
G
I
V
R
Y
F
N
A
W
L
E
A
P
P
----------------------
K
V
Y
--------------------------------
L
Y
I
Q
M
Q
L
C
R
K
E
N
L
K
D
W
M
N
G
R
C
-
T
--
I
E
E
R
E
R
S
V
C
L
H
-
I
F
L
Q
I
A
E
A
V
E
F
L
H
S
K
G
L
M
H
R
N
L
K
P
S
N
I
F
F
T
M
D
D
-
V
V
K
V
G
D
F
G
L
V
------------------------------
K
L
Y
M
S
P
E
Q
I
H
G
N
-
S
Y
S
H
K
V
-----
D
I
F
S
L
G
L
I
L
F
E
L
L
Y
-
P
F
S
T
Q
M
E
R
V
R
--
T
L
T
D
V
R
N
L
K
--
F
P
P
L
F
T
Q
K
Y
P
C
-----
E
Y
V
M
V
Q
D
M
L
S
P
S
P
M
E
R
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
63.93
28%
-33
- C1 -
-
4X7K
3
A:
[21-289]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
P
I
Q
C
L
G
R
G
G
F
G
V
V
F
E
A
K
N
K
V
D
D
C
N
Y
A
I
K
R
I
R
L
P
N
R
E
L
A
R
E
K
V
M
R
E
V
K
A
L
A
K
L
E
H
P
G
I
V
R
Y
F
N
A
W
L
E
A
P
P
----------------------
K
V
Y
--------------------------------
L
Y
I
Q
M
Q
L
C
R
K
E
N
L
K
D
W
M
N
G
R
C
-
T
--
I
E
E
R
E
R
S
V
C
L
H
-
I
F
L
Q
I
A
E
A
V
E
F
L
H
S
K
G
L
M
H
R
N
L
K
P
S
N
I
F
F
T
M
D
D
-
V
V
K
V
G
D
F
G
L
V
T
----------------------------
T
K
L
Y
M
S
P
E
Q
I
H
G
N
-
S
Y
S
H
K
V
-----
D
I
F
S
L
G
L
I
L
F
E
L
L
Y
-
P
F
S
T
Q
M
E
R
V
R
--
T
L
T
D
V
R
N
L
K
--
F
P
P
L
F
T
Q
K
Y
P
C
-----
E
Y
V
M
V
Q
D
M
L
S
P
S
P
M
E
R
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
63.68
28%
-34
- C1 -
-
4X7L
3
A:
[21-289]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
P
I
Q
C
L
G
R
G
G
F
G
V
V
F
E
A
K
N
K
V
D
D
C
N
Y
A
I
K
R
I
R
L
P
N
R
E
L
A
R
E
K
V
M
R
E
V
K
A
L
A
K
L
E
H
P
G
I
V
R
Y
F
N
A
W
L
E
A
P
P
----------------------
K
V
Y
--------------------------------
L
Y
I
Q
M
Q
L
C
R
K
E
N
L
K
D
W
M
N
G
R
C
-
T
--
I
E
E
R
E
R
S
V
C
L
H
-
I
F
L
Q
I
A
E
A
V
E
F
L
H
S
K
G
L
M
H
R
N
L
K
P
S
N
I
F
F
T
M
D
D
-
V
V
K
V
G
D
F
G
L
V
T
----------------------------
T
K
L
Y
M
S
P
E
Q
I
H
G
N
-
S
Y
S
H
K
V
-----
D
I
F
S
L
G
L
I
L
F
E
L
L
Y
-
P
F
S
T
Q
M
E
R
V
R
--
T
L
T
D
V
R
N
L
K
--
F
P
P
L
F
T
Q
K
Y
P
C
-----
E
Y
V
M
V
Q
D
M
L
S
P
S
P
M
E
R
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
63.35
28%
-31
- C1 -
-
4X7N
2
A:
[21-289]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
P
I
Q
C
L
G
R
G
G
F
G
V
V
F
E
A
K
N
K
V
D
D
C
N
Y
A
I
K
R
I
R
L
P
N
R
E
L
A
R
E
K
V
M
R
E
V
K
A
L
A
K
L
E
H
P
G
I
V
R
Y
F
N
A
W
L
E
A
P
-----------------------
K
V
Y
--------------------------------
L
Y
I
Q
M
Q
L
C
R
K
E
N
L
K
D
W
M
N
G
R
C
-
T
--
I
E
E
R
E
R
S
V
C
L
H
-
I
F
L
Q
I
A
E
A
V
E
F
L
H
S
K
G
L
M
H
R
N
L
K
P
S
N
I
F
F
T
M
D
D
-
V
V
K
V
G
D
F
G
L
V
T
----------------------------
T
K
L
Y
M
S
P
E
Q
I
H
G
N
-
S
Y
S
H
K
V
-----
D
I
F
S
L
G
L
I
L
F
E
L
L
Y
-
P
F
S
T
Q
M
E
R
V
R
--
T
L
T
D
V
R
N
L
K
--
F
P
P
L
F
T
Q
K
Y
P
C
-----
E
Y
V
M
V
Q
D
M
L
S
P
S
P
M
E
R
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
63.32
22%
-89
- C1 -
-
5T18
1
A:
[6-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
K
D
L
T
F
L
K
E
L
G
T
G
Q
F
G
V
V
K
Y
G
K
W
R
-
G
Q
Y
D
V
A
I
K
M
I
K
E
G
S
M
S
--
E
D
E
F
I
E
E
A
K
V
M
M
N
L
S
H
E
K
L
V
Q
L
Y
G
V
C
T
K
Q
---------------------------------------------------------
R
P
I
F
I
I
T
E
Y
M
A
N
G
C
L
L
N
Y
L
R
E
------
F
Q
T
Q
Q
---
L
L
E
-
M
C
K
D
V
C
E
A
M
E
Y
L
E
S
K
Q
F
L
H
R
D
L
A
A
R
N
C
L
V
N
D
Q
G
-
V
V
K
V
S
D
F
G
L
S
R
Y
V
L
D
D
E
Y
-------------
T
S
S
V
G
S
K
F
P
V
R
W
S
P
P
E
V
L
M
Y
S
-
K
F
S
S
K
S
-----
D
I
W
A
F
G
V
L
M
W
E
I
Y
S
L
G
K
M
P
Y
E
R
F
T
N
S
E
T
A
E
H
I
A
Q
G
L
--
R
L
Y
R
P
H
L
A
S
E
K
-----
V
Y
T
I
M
Y
S
C
W
H
E
K
A
D
E
R
P
T
F
K
I
L
L
S
N
I
L
D
V
M
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
62.82
30%
-
- C1 -
-
3QD2
-
E2AK3_MOUSE
B:
[589-1064]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
P
I
Q
C
M
G
R
G
-
F
G
V
V
F
E
A
K
N
K
V
D
D
C
N
Y
A
I
K
R
I
R
L
P
N
R
E
LA
R
E
K
V
M
R
E
V
K
A
L
A
K
L
E
H
P
G
I
V
R
Y
F
N
A
W
L
E
T
P
P
E
K
W
Q
E
E
M
D
E
--------------------------------------------
P
K
V
Y
L
Y
I
Q
M
Q
L
C
R
K
E
N
L
K
D
W
M
N
R
R
C
-
S
--
L
E
D
R
E
HGV
C
L
H
-
I
F
I
Q
I
A
E
A
V
E
F
L
H
S
K
G
L
M
H
R
D
L
K
P
S
N
I
F
F
T
M
D
D
-
V
V
K
V
G
D
F
G
L
V
T
A
M
D
Q
D
--------------
T
H
T
G
Q
V
---
T
K
L
Y
M
S
P
E
Q
I
H
G
N
-
N
Y
S
H
K
V
-----
D
I
F
S
L
G
L
I
L
F
E
L
L
Y
-
S
F
S
T
Q
M
E
R
V
R
--
I
I
T
D
V
R
N
L
K
--
F
P
L
L
F
T
Q
K
Y
P
Q
-----
E
H
M
M
V
Q
D
M
L
S
P
S
P
T
E
R
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
62.61
29%
-33
- C1 -
-
4G31
2
A:
[7-272]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
P
I
Q
C
L
G
R
G
--
G
V
V
F
E
A
K
N
K
V
D
D
C
N
Y
A
I
K
R
I
R
L
P
N
R
E
L
A
R
E
K
V
M
R
E
V
K
A
L
A
K
L
E
H
P
G
I
V
R
Y
F
N
A
W
L
E
K
---
N
--------------------
K
V
Y
--------------------------------
L
Y
I
Q
M
Q
L
C
R
K
E
N
L
K
D
W
M
N
G
R
C
-
T
--
I
E
E
R
E
R
S
V
C
L
H
-
I
F
L
Q
I
A
E
A
V
E
F
L
H
S
K
G
L
M
H
R
D
L
K
P
S
N
I
F
F
T
M
D
D
-
V
V
K
V
G
D
F
G
L
V
----------------------------
G
T
K
L
Y
M
S
P
E
Q
I
H
G
N
-
S
Y
S
H
K
V
-----
D
I
F
S
L
G
L
I
L
F
E
L
L
Y
-
P
F
S
T
Q
M
E
R
V
R
--
T
L
T
D
V
R
N
L
K
--
F
P
P
L
F
T
Q
K
Y
P
C
-----
E
Y
V
M
V
Q
D
M
L
S
P
S
P
M
E
R
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
61.90
29%
-34
- C1 -
-
4M7I
1
A:
[7-272]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
P
I
Q
C
L
G
R
--
F
G
V
V
F
E
A
K
N
K
V
D
D
C
N
Y
A
I
K
R
I
R
L
P
N
R
E
L
A
R
E
K
V
M
R
E
V
K
A
L
A
K
L
E
H
P
G
I
V
R
Y
F
N
A
W
L
E
K
------------------------
K
V
Y
--------------------------------
L
Y
I
Q
M
Q
L
C
R
K
E
N
L
K
D
W
M
N
G
R
C
-
T
--
I
E
E
R
E
R
S
V
C
L
H
-
I
F
L
Q
I
A
E
A
V
E
F
L
H
S
K
G
L
M
H
R
D
L
K
P
S
N
I
F
F
T
M
D
D
-
V
V
K
V
G
D
F
G
L
V
----------------------------
G
T
K
L
Y
M
S
P
E
Q
I
H
G
N
-
S
Y
S
H
K
V
-----
D
I
F
S
L
G
L
I
L
F
E
L
L
Y
-
P
F
S
T
Q
M
E
R
V
R
--
T
L
T
D
V
R
N
L
K
--
F
P
P
L
F
T
Q
K
Y
P
C
-----
E
Y
V
M
V
Q
D
M
L
S
P
S
P
M
E
R
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
61.63
29%
-20
- C1 -
-
3UIU
-
E2AK2_HUMAN
A:
[261-537]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
F
G
M
D
F
K
E
I
E
L
I
G
S
G
G
F
G
Q
V
F
K
A
K
H
R
I
D
G
K
T
Y
V
I
R
R
V
K
Y
N
N
E
K
--
A
E
R
E
V
K
A
L
---
A
K
L
D
H
V
N
I
V
H
Y
N
G
C
W
--------------------
D
G
F
D
Y
D
P
-
E
T
S
---------------------
R
S
K
T
----
K
C
L
F
I
Q
M
E
F
C
D
K
G
T
L
E
Q
W
I
E
K
R
R
-
G
EK
L
D
K
V
L
---
A
L
E
-
L
F
E
Q
I
T
K
G
V
D
Y
I
H
S
K
K
L
I
H
R
D
L
K
P
S
N
I
F
L
V
D
T
K
-
Q
V
K
I
G
D
F
G
L
V
T
S
L
--------------------------
T
L
R
Y
M
S
P
E
Q
I
-----
Y
G
K
E
V
-----
D
L
Y
A
L
G
L
I
L
A
E
L
L
H
-
V
C
D
T
A
F
E
T
S
K
--
F
F
T
D
L
R
D
G
I
--
I
S
D
I
F
D
K
K
--------
E
K
T
L
L
Q
K
L
L
S
K
K
P
E
D
R
P
N
T
S
E
I
L
R
T
L
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
60.24
28%
-31
- C1 -
-
4X7H
1
A:
[21-289]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
P
I
Q
C
L
G
R
G
G
F
G
V
V
F
E
A
K
N
K
V
D
D
C
N
Y
A
I
K
R
I
R
L
P
N
R
E
L
A
R
E
K
V
M
R
E
V
K
A
L
A
K
L
E
H
P
G
I
V
R
Y
F
N
A
W
L
E
A
P
P
----------------------
K
V
Y
--------------------------------
L
Y
I
Q
M
Q
L
C
R
K
E
N
L
K
D
W
M
N
G
R
C
-
T
--
I
E
E
R
E
R
S
V
C
L
H
-
I
F
L
Q
I
A
E
A
V
E
F
L
H
S
K
G
L
M
H
R
N
L
K
P
S
N
I
F
F
T
M
D
D
-
V
V
K
V
G
D
F
-------------------------------
G
T
K
L
Y
M
S
P
E
Q
I
H
G
N
-
S
Y
S
H
K
V
-----
D
I
F
S
L
G
L
I
L
F
E
L
L
Y
-
P
F
S
T
Q
M
E
R
V
R
--
T
L
T
D
V
R
N
L
K
--
F
P
P
L
F
T
Q
K
Y
P
C
-----
E
Y
V
M
V
Q
D
M
L
S
P
S
P
M
E
R
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
60.03
23%
-71
- C1 -
-
4G3F
1
A:
[56-318]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
H
W
M
T
H
Q
P
R
V
G
R
G
S
F
G
E
V
H
R
M
K
D
K
Q
T
G
F
Q
C
A
V
K
K
V
R
L
E
V
------
F
R
V
E
E
L
V
A
C
A
G
L
S
S
P
R
I
V
P
L
Y
G
A
V
R
E
G
---------------------------------------------------------
P
W
V
N
I
F
M
E
L
L
E
G
G
S
L
G
Q
L
I
K
Q
M
G
-
C
--
L
P
E
D
R
---
A
L
Y
-
Y
L
G
Q
A
L
E
G
L
E
Y
L
H
T
R
R
I
L
H
G
D
V
K
A
D
N
V
L
L
S
S
D
G
S
R
A
A
L
C
D
F
G
H
A
L
C
L
---------------------
D
Y
I
P
G
T
E
T
H
M
A
P
E
V
V
M
G
K
-
P
C
D
A
K
V
-----
D
I
W
S
S
C
C
M
M
L
H
M
L
N
-
G
C
H
P
W
T
Q
Y
F
R
GP
L
C
L
K
I
A
S
E
P
PP
I
R
E
I
P
P
S
C
A
P
L
-----
T
A
Q
A
I
Q
E
G
L
R
K
E
P
V
H
R
A
S
A
M
E
L
R
R
K
V
G
K
A
L
Q
E
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
58.96
28%
5
- C1 -
-
2A19
1
E2AK2_HUMAN
B:
[2-270]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
H
T
V
D
K
R
F
G
M
D
F
K
E
I
E
L
I
G
S
G
G
F
G
Q
V
F
K
A
K
H
R
I
D
G
K
T
Y
V
I
K
R
V
K
Y
N
N
E
K
--
A
E
R
E
V
K
A
L
---
A
K
L
D
H
V
N
I
V
H
Y
N
G
C
W
--------------------
D
G
F
D
Y
D
---------
R
S
K
T
K
---------------------
C
L
F
I
Q
M
E
F
C
D
K
G
T
L
E
Q
W
I
E
K
R
R
-
G
EK
L
D
K
V
L
---
A
L
E
-
L
F
E
Q
I
T
K
G
V
D
Y
I
H
S
K
K
L
I
N
R
D
L
K
P
S
N
I
F
L
V
D
T
K
-
Q
V
K
I
G
D
F
G
L
V
T
S
L
K
N
-------------
D
G
K
R
T
R
S
--
K
G
T
L
R
Y
M
S
P
E
Q
I
S
S
Q
-
D
Y
G
K
E
V
-----
D
L
Y
A
L
G
L
I
L
A
E
L
L
H
-
V
C
D
T
A
F
E
T
S
K
--
F
F
T
D
L
R
D
G
I
--
I
S
D
I
F
D
K
K
--------
E
K
T
L
L
Q
K
L
L
S
K
K
P
E
D
R
P
N
T
S
E
I
L
R
T
L
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
58.11
28%
8
- C1 -
-
2A1A
-
E2AK2_HUMAN
B:
[255-537]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
A
H
T
V
D
K
R
F
G
M
D
F
K
E
I
E
L
I
G
S
G
G
F
G
Q
V
F
K
A
K
H
R
I
D
G
K
T
Y
V
I
K
R
V
K
Y
N
N
E
K
--
A
E
R
E
V
K
A
L
---
A
K
L
D
H
V
N
I
V
H
Y
N
G
C
W
--------------------
D
G
F
D
Y
D
P
E
T
S
S
----
R
S
K
T
K
---------------------
C
L
F
I
Q
M
E
F
C
D
K
G
T
L
E
Q
W
I
E
K
R
R
-
G
EK
L
D
K
V
L
---
A
L
E
-
L
F
E
Q
I
T
K
G
V
D
Y
I
H
S
K
K
L
I
N
R
D
L
K
P
S
N
I
F
L
V
D
T
K
-
Q
V
K
I
G
D
F
G
L
V
T
S
L
K
N
-------------
D
G
K
R
T
R
S
--
K
G
T
L
R
Y
M
S
P
E
Q
I
S
S
Q
-
D
Y
G
K
E
V
-----
D
L
Y
A
L
G
L
I
L
A
E
L
L
H
-
V
C
D
T
A
F
E
T
S
K
--
F
F
T
D
L
R
D
G
I
--
I
S
D
I
F
D
K
K
--------
E
K
T
L
L
Q
K
L
L
S
K
K
P
E
D
R
P
N
T
S
E
I
L
R
T
L
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
57.25
28%
-37
- C1 -
-
4X7O
1
A:
[21-289]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
P
I
Q
C
L
G
R
G
--
G
V
V
F
E
A
K
N
K
V
D
D
C
N
Y
A
I
K
R
I
R
L
P
N
R
E
L
A
R
E
K
V
M
R
E
V
K
A
L
A
K
L
E
H
P
G
I
V
R
Y
F
N
A
W
L
E
A
P
P
----------------------
K
V
Y
--------------------------------
L
Y
I
Q
M
Q
L
C
R
K
E
N
L
K
D
W
M
N
G
R
C
-
T
--
I
E
E
R
E
R
S
V
C
L
H
-
I
F
L
Q
I
A
E
A
V
E
F
L
H
S
K
G
L
M
H
R
N
L
K
P
S
N
I
F
F
T
M
D
D
-
V
V
K
V
G
D
F
-------------------------------
G
T
K
L
Y
M
S
P
E
Q
I
H
----
Y
S
H
K
V
-----
D
I
F
S
L
G
L
I
L
F
E
L
L
Y
-
P
F
S
T
Q
M
E
R
V
R
--
T
L
T
D
V
R
N
L
K
--
F
P
P
L
F
T
Q
K
Y
P
C
-----
E
Y
V
M
V
Q
D
M
L
S
P
S
P
M
E
R
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------