@TOME V2.3
(Mar 2018)
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
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Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_34_3750: (2018-03-12 )
MAETLAPNDVGGISVTKLFSSDSTAALGQQLSSIFSNLNSTPNDRQQRAEECLSALTDTLFLHENELGANESLHERIIALIDGTFCTSVDKGCSSFRVVFDVKWKDQHEKRNRCFVLLLSRAFKCTTPEDCLKVIQCLGEVLEDNIRTTTDLLADNVEPLLRDLFAADVHRRTVACEVLAKIVSTTTFIIKRNPTLLELLTSSCAPLVTLKDAMETRNLWHRTALIRLTSALVENCYEVTPAVAKDVADLVFRYMRAAEDESQLVGVLSALIHVAVTPAFVSAPWDLPQLVRFLCETDWSVYAVATRVAAVAAINKVAFFFCQEEKACYEALRTRSLEFISLDDAVEVVTEGLELIKEMEVLERELHLGTAVVNALCACIQRLPHVPIIYELLELIRERYGDLEVKPIYSLLEGYLDTKQELLNFGKVNALLRFAGPRIRLDDPRLAQLRINVGANQPIPVILHSLPLLTTLQRTEQLHEVLEILSHDDRGVRRVAVSTALELCEIMMERNKFRNATPKGGVQRMQWLDEEVSNAVERVLDVAVADRDPEIRLWALQHLTVPFFPYLCLCDNLDAIFMARNDNDKATRDQALTLLCQLLPYHPTVVQPQLQRAQEYMLHDVATMDASVSFAVCKAGLLKMCVDHEALLIEKSTVEAIVLRRLEAQPFISRSLSIALLQLIRSILERTASQHHSDFHSFLRPLLLIVNGGDSCTRRREALETLTAFISHITKTDISGLSEVYRAVARIIRRETEEEESVTIAAMKVLSSIGAVTPVKMRHVFRMVESDEMEEEEEVVTPALAHCKPRLRISTDMPERYPSTVLYYLVRSLQLALDPKQQVDTLVAVRTMLHDVEGKVKLNLLTQLLPQLQTWLRDPERAFLYETVLGLMNDLAILLCQFKESVAPSVGHELLRSVQAFCLLPQASQKPFSAYVVQLLDSLAKGIPAQEMRDNRWAIEFIHQRLSQNKNDLDLVHRVVKSLESFIAVMHEKELQMILPHVLQCIEPAKASPGGKLSKSKDINDACFDFLNFVMAKQLTLVKHCCAQIVHTIMWYIELADSNEEMDVGLNTLATLVDTVKMPAKRFIMPIERVAVRNGFPPQYFVNLVQSAAGGAKIRMTTSNGTGLNPDRPITLVSHLPRLSQAEFEHEMRSTPRSENVLIDVLDVRHHQGQTMIDFRFHPGTDTAACCNLFSRKATDNKSAMRRNLGILRVEQTEESPRPVGADVIKALANLPVAKTKKREQSWVLWLHNATVTLLRNSPYAVLRDTCAVADRNTELAKDLFPFAVAAVCGHLETPLRAQLMDIFDRALAAAPADVKQGLFCFAEFMESERDDDRVKLVKVMRESVFSVDRESTSQKFGINYDQDPERGVIVTKLAPNGLGARAGVPIGAQLLAINDIPVRAVSDIRGLIEGLTHIELLLSYEVEEKTKSKPKPLMNLEVLASVAFSGEMHIKAIYFNEVLFESLSSKICKITDRKDSQMRRVMTIAEDLIQYYRHLNMTMTANGLLKTLTRKFSDEIFAPEQFGFEEIASLEQLNWWSEALRRYEARMASFGARYLEVASLVGVLRCEQALGHSSRVQELAEQYWEQLPVDAQREVAPFRAKAAFCLGAWDTFDALALDKRMQSCFGVVERCAALFRAECHDELLRYTDKVRESMLESFADSLNENYNRAYEGMTRLQHLRHFEELVSFTTACEERQALLKRVWHRRLVQMSSRPDDLMTVLSINSLVLEPEDDLHSYVYVIRCLCKSQWFSHAEHLLQRLLRENASLEVLCECDPELIHTYIKYVYLAKDKHGAYVELKNILSAVEVDPEDPRAEMWGQCWLLLGEWTMYLFPDCGEEAIKELMCATELGPNSAAAFHSLGILHCDLARDPSTQGEVQNNHLICCINSLFKSIQLCNDVPGSLVMQDVLRILSVWFANSSIREINEAVHHGVQVVADHVWLNVVPQLIARIGIEARYARAILTDLLIRVGSQYSHALIYPLTVAEKSPDAVRRHMAERVIMGMRNIPENDRIVKEASLVSNEMVRIAILWTEKWHAAIQQAAYKPNNTAAIFSMLQPLYAELDRASTPNELSFRCNFGQTLRRAKVALEEAKTEEAWGFLRQVYAQLRRGVLERRLYMSDVSPTLDGIQDSIVAVPGTFEHDKPLITILKFHSRVYVMPSKQKPRRIGLDASDGKKYRFLLKGHEDMRQDERVMQFIRLIDTIFQSDNAASAIGLSIPQYAVIPLTDNVGVVGWVENTETIYKMLETYRQAHEVSIYEEVNLIMKKGGLDTIEDYHRLPKQQRKALLNYAMENTPKNELRHIFWDHNDTCEQWLSYRQTYGQTLAAMSMVGYVLGLGDRHLNNLMLQGNGTVVHIDFGDCFEVAMHRALYAEAVPFRLTRLLVCALGITGVDGLYRMTCELAMKNLHRHSENLLSILEAFIYDPIINWRLNTVNDVTEKSGSKSAQQESSNGGTAALAGETAAAACLGVDDAAQAEAKPVAMQLSKSVSKLVPHSALPGESQMFENGEETRNQQGDLALARVQAKLTGQDFGVVNSSFSMMRSSRRLEAGGSQPQGSSWGSNSLAGFTDSPKDSFAAPLLTTYLSLRVLNGGAESLDVPHQVDRLIQEATSLDNLSDAFLTGWAPFW
Atome Classification :
(20 SA)
.........10........20........30......-..40........50........60........--70-.........80-.-----.--......90........100.-----------.-----------.--....110.......120.......130.......140..-....---.150.......160..----..-----...170.......180..---..-..-----.----190.-......200-...--.--...210.......220.......230.......240.-.--.......250...----..--------------------.-.------------------260.-.-.......270-------.......-.280---........290...-..-..300.........310.......320--.......330.......340.......350.......360.......370.......380.-.....-.390.......400----.........410.......420.......430.......440.......450.......460.......470......-.480...-.-.-..490.......500.......510.......520.......530.......540...-----------....550.......560......--------.-------570.......580-...-------....590.......600..-.-------.....610.......620-.--......630..---.-----....640.......-650---.---.......660....-------------..---------------------------------.----670.......680.......690.......700..-....-.-----------------710........720.......730-----.--.--....--.740.......750......-.760.-......-----770.......780.......790.......800.......810......--.820....-...830---------------.-----------------..--......840.......850...--....860--.......870...-.-----------..----------.880.......890.......---900---...--......910.......920--..------------.......930.......940.-..-.-..-.950........960.-----.-----.--.-.-..970.......980.......990.......1000-.-.-....1010......1020......1030----...-.....--1040......--1050...----...-1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310.......1320......1330......1340......1350......1360......1370......1380......1390......1400......1410......1420......1430......1440......1450......1460......1470......1480......1490......1500......1510......1520......1530......1540......1550......1560......1570......1580......1590......1600......1610......1620....--------..1630......1640......1650......1660....-..1670......1680......1690.--.....1700......1710......1720......1730......1740......1750......--1760......1770.........1780.....----.1790......1800......-----1810----------...-----------....1820......1830--.....----..1840......1850.....--------.1860......1870......-----------------1880------------........-1890......1900......1910......1920......1930......1940........1950......1960......1970......1980......1990......2000......2010......2020......2030......2040---...---...2050......2060..-....2070......2080......2090.-------.....2100..---....2110.-.....2120.....----.2130......2140......2150.-.-....2160......2170.-----.------..-----..2180......2190......2200......2210......2220......2230......2240...--------...2250......2260......2270......2280......2290......2300......--2310--........2320......2330......2340....-..2350......2360......-2370......2380......2390-.-------.-----.----....2400......2410......2420.---.....2430......2440......2450......2460......2470......2480......2490.....----.2500......2510......2520......2530......2540......2550......2560......2570......2580......2590......2600......2610......2620.....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MAETLAPNDVGG
I
S
V
T
K
L
FSSD
S
T
A
A
L
G
Q
Q
L
S
S
I
F
S
N-LNSTP
N
D
R
Q
Q
R
A
E
E
C
L
S
A
L
T
D
T
L
F
L
HENELGA--
N
--
E
S
L
H
E
R
I
I
A
L
I-D-----G--TFCT
S
V
D
KGCSS
F
R
V
V
F
D
V
K
-----------W-----------K--
D
Q
H
EKRNR
C
F
V
L
L
L
S
R
AFKCT
T
P
E
D
C
L
K
V
I
Q
C
L
G
E
V
L
E
D
-
N
IR
T
---
T
T
D
L
L
A
D
N
V
E
P
L
L
R
D
L
----
F
A
-----
A
D
V
H
R
R
T
V
A
C
E
V
L
A
K
I
V
S
---
T
T
-
T
F
-----
I
----
I
KRN-
P
T
L
L
E
L
L
T
S-SCA--
P
--
L
V
T
L
K
D
A
M
E
T
R
N
L
W
H
R
T
A
L
I
R
L
T
S
A
L
V
E
N
C
Y
EV
T
--
P
-
A
--
V
A
K
D
V
A
D
L
V
F
R
Y
M
----
R
A--------------------A-E------------------D--
E
-
S
-
Q
L
V
G
V
L
S
A
L
--------
I
H
V
AVT
P
-
A
FV----SAPW
D
L
P
Q
L
V
R
F
L
C-ET-DW
S
--
V
Y
A
V
A
T
R
V
A
A
V
A
A
I
N
K
V
A
F
F
F
C--Q
E
E
K
A
C
Y
E
A
L
R
TRS
L
E
F
I
SL
D
D
A
V
E
V
V
T
E
G
L
E
L
I
K
E
M
E
V
L
E
R
E
LH
L
G
T
A
V
V
N
A
L
C
A
C
I
Q
RL-PH
V
P
I
-
I
Y
E
L
L
E
L
I
R
E
R
Y------GDL
E
V
K
P
I
Y
S
L
L
E
G
Y
L
D
T
K
Q
E
L
L
N
F
G
K
V
N
A
L
L
R
FAG
P
R
I
RLDDP
R
L
A
Q
L
R
I
NVGANQ
P
I
P
V
I
L
HS
L
P
L
L
T
T
L
Q
R
T
E
Q
L
-
H
E
V
L
E
I
L-S-H-DDRG
V
R
R
V
A
V
S
T
A
L
E
L
C
E
I
M
M
E
R
N
K
FRNATPKG
G
V
Q
R
M
Q
W
L
D
E
E
V
S
N
A
V
E
R
V
L
D
V
AVA-----------DRDP
E
I
R
L
W
A
LQHLTV
P
F
F
P
Y
L
C
--------
L
-------CDNL
D
A
I
F
M
ARND-ND
K
-------
A
T
R
D
Q
A
L
T
L
L
C
Q
LLP-YHP-T-------VV
Q
P
Q
L
Q
R
A
Q
E
Y
M
L
H
D
V
A-T--MDA
S
V
S
F
A
V
C
K
---
A
-----
G
L
L
K
M
CVDH
E
A
L
L
I
-
E
K
----
S
---
T
V
E
A
I
V
L
R
R
LEAQ
P
-------------
F
I
---------------------------------
S
----
R
S
L
S
I
A
L
L
Q
L
I
R
S
I
L
E
R
T
A
S
Q
H
H
S
D
F
H
S
F
L
R
P
L
L
L
-
I
VNG-G-----------------
D
-
S
C
T
R
R
R
E
A
L
E
T
L
T
A
F
I
S
H
I
T
KT-----
D
--
I
--
S
G
L
S
--
E
V
Y
R
A
V
A
R
I
I
R
RETEEEE
S
V
-
T
I
A
A
M
-
K
V
L
S
SI-----GAV
T
P
V
K
M
R
H
V
F
R
M
VESDE
M
E
E
E
E
E
VV
T
P
A
L
A
HCKP
R
L
R
ISTDMPERY
P
--
S
T
V
L
Y
Y
L
V
-
R
S
L
Q
-----------------L-----------------AL--D
P
K
Q
Q
V
D
T
L
V
A
V
R
T
M
L
H
DVEGK--
V
K
L
N
L
L
T
--
Q
L
L
P
Q
L
Q
T
W
LRD
P
-
E
-----------
R
A
----------
F
L
Y
E
T
V
L
G
L
M
N
D
L
A
I
L
L
C
Q
F
K
---
E
-----SV
A
--
P
S
V
G
H
E
L
L
R
S
V
Q
A
F
CLL----PQ------------ASQK
P
F
S
A
Y
V
V
Q
L
L
D
S
L
A
KGI-
P
A
-
Q
-
E
M-RDN-
R
W
A
I
E
F
I
H
Q
R
L
S-----Q-----N--K-N-
D
L
D
L
V
H
R
V
V
K
S
L
E
S
F
I
A
V
M
H
E
K
E
L
Q
M
I
L
P
H
V
L
Q
C
IE-P-A-KASPGGKLSKSKDI
N
D
A
C
F
D
F
L
N
F
V
M
------
A
K
Q
-
L
T
L
V
K
--
H
C
C
A
Q
I
V
H
T
I
--
M
W
Y
I
E
LA----DSN-EE
M
D
V
G
L
N
T
L
A
T
L
V
D
T
V
KM
P
A
K
R
F
I
M
P
I
E
R
V
A
VRNGF
P
P
Q
Y
F
V
N
L
V
Q
SAAGG
A
K
I
R
M
TTSNGTGLNPDRP
I
T
L
V
S
HLPR
L
S
Q
A
E
F
E
H
E
M
RSTPRSE
N
V
L
I
D
V
LDVRHHQG
Q
T
M
I
D
F
R
FHPGT
D
T
A
A
C
C
N
L
F
SRKATD
N
K
S
A
M
R
RNL
G
I
L
R
V
EQTEESPRPV
G
A
D
V
I
K
A
L
ANLPVAKTKKREQ
S
W
V
L
W
LHN
A
T
V
T
L
LRNS
P
Y
A
V
L
R
D
T
C
AVADR
N
T
E
L
A
K
D
L
F
P
F
A
V
A
A
V
CGHLET
P
L
R
A
Q
L
M
D
I
F
D
R
A
LAAA
P
-
A
D
V
K
Q
G
L
F
C
F
A
E
F
M
E
SERD
D
D
R
V
K
L
V
K
V
M
R
E
S
V
F
SVDRESTSQKFGINYDQDPER
G
V
I
V
T
K
LAPNGLGARAGVPI
G
A
Q
L
L
A
INDI
P
V
R
A
V
S
D
I
R
G
L
I
E
G
L
T
H
I
E
L
L
L
S
Y
E
V
E
E
KTKSKPKP
L
M
N
L
E
V
L
A
S
V
AFSG
E
M
H
I
K
A
I
Y
F
N
E
V
L
F
E
S
L
S
S
K
I
C
K
ITDR
K
D
S
Q
M
R
R
V
M
T
I
A
E
D
L
I
Q
Y
Y
R
HLN
M
T
MTA
N
G
L
L
K
T
L
T
R
K
F
S
D
EIFA
P
E
QF
G
F
E
E
I
A
S
L
E
Q
L
N
W
W
S
E
A
L
R
R
Y
E
A
R
M
A
S
F
G
A
R
Y
L
E
V
A
S
L
V
G
V
L
R
C
E
Q
A
LG
H
S
S
R
V
Q
E
L
A
E
Q
Y
W
E
QLPVDAQREVAPFRA
K
A
A
F
C
LGAW
D
T
F
D
A
L
A
L
D
K
R
M
Q
S
C
F
G
--------
V
V
E
R
C
A
A
L
F
R
A
E
C
H
D
E
L
L
R
Y
T
D
K
V
R
E
S
M
L
E
S
F
A
D
S
L
N
E
N
Y
-
N
R
A
Y
E
G
M
T
R
L
Q
H
L
R
H
F
E
E
L
V
S
F
T
T
A
C
E
--
E
R
Q
A
L
L
K
R
V
W
H
R
R
L
V
Q
MSSRP
D
D
L
M
T
V
L
S
I
N
S
L
V
LEPE
D
D
L
H
S
Y
V
Y
V
I
R
C
L
C
K
S
Q
W
F
S
H
A
E
H
L
L
Q
--
R
L
L
RENA
S
L
E
V
---
L
CEC
D
P
E
L
I
H
T
Y
I
K
Y
V
Y
L
----AKDKHG
A
Y
V
E
L
K
N
I
L
S
A
VEVD-----PED-----------
P
R
A
-----------
E
M
W
G
Q
C
W
L
L
LGE
W
T
M
Y
L---FPDC
G
----
E
E
A
I
K
E
L
M
C
A
TELGPN
S
A
A
A
F
--------
H
S
L
G
I
L
H
CDLARDPSTQGEVQ-----------------N
N
--------------
H
L
I
C
C
I
N
S
-
L
F
K
S
I
Q
L
C
NDV
P
G
S
L
V
M
Q
D
V
L
R
I
L
S
V
W
FAN
S
S
I
R
E
I
N
E
A
V
H
H
G
V
Q
V
V
A
D
H
V
W
--
L
N
V
V
P
Q
L
I
A
RIGI
E
A
R
Y
A
R
A
I
L
T
D
L
L
I
R
VGSQYS
H
A
L
I
Y
P
L
TVAEK
S
P
D
A
V
R
R
H
M
A
E
R
V
I
M
G
M
RNIPEN
D
R
I
V
K
E
A
S
LVSN
E
M
V
R
I
A
I
L
W
T
E
K
W
H
A
A
I
Q
Q
AA---YKP---N
N
T
A
A
I
F
S
M
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LDR-ASTPN
E
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RCN
F
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V
A
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EAK
T
-------
E
E
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---
A
Q
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MSDVS
P
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MPSKQKPRRIGLDASD-----G------
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-----
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LKG
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LNT
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EKSGSKSAQQESSNGG
T
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LAGE
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LTGWAPFW
62
Fugue
52.92
25%
1
- C1 -
-
5H64
-
MTOR_HUMAN
A:
[210-2549]
---------------------------
V
A
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---------------------------------------------------------------------------
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----
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---
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------------------------------------------------------------------------------
T
A
L
N
K
K
A
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Q
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N
R
V
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K
L
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R
D
F
S
-----------------------------------------------------------
H
D
D
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L
L
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A
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H
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N
L
C
Q
C
Y
I
-
G
W
C
P
F
W
63
Fugue
49.57
30%
-28
- C1 -
-
4JSP
1
MTOR_HUMAN
A:
[10-1174]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
A
A
K
C
R
A
Y
A
K
A
L
H
Y
K
E
L
E
F
Q
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P
T
----------------
P
A
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---------------------------------------------------------------------------------------------------------------------------
61
Fugue
47.91
26%
-0
- C1 -
-
5FVM
-
?
A:
[85-2469]
---
N
V
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------
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----------------------------------------------
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---------------------------------------------------------------------------------------------------
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R
I
H
Q
P
N
Q
T
V
S
R
S
L
L
S
L
L
A
D
L
G
K
A
H
P
Q
A
L
V
Y
P
L
T
V
A
I
K
S
D
S
V
S
R
Q
R
A
A
L
S
I
I
D
K
M
R
M
--
H
S
P
K
L
V
N
Q
A
E
L
V
S
D
E
L
I
R
V
A
V
L
W
H
E
L
W
Y
E
G
L
E
D
A
S
---
R
Q
F
F
G
E
H
N
T
E
K
M
F
A
T
L
E
P
L
H
E
M
L
K
R
G
P
E
T
L
R
E
I
S
F
Q
N
S
F
G
R
D
L
N
D
A
Y
E
W
V
L
N
Y
K
R
TKDI
N
N
L
N
Q
A
W
D
I
Y
Y
N
V
F
---
R
R
I
S
R
K
L
P
Q
L
Q
T
L
D
L
Q
H
V
S
P
K
L
S
A
----
A
K
D
L
E
L
A
V
P
G
T
Y
H
A
G
K
P
I
V
R
I
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H
F
E
P
-
V
-
F
T
V
I
S
S
K
Q
R
P
R
R
V
I
I
K
G
S
D
-----
G
------
K
D
-----
Y
Q
Y
L
L
K
S
H
E
D
I
R
Q
D
N
L
V
M
Q
L
F
G
L
V
N
T
L
L
Q
N
D
P
E
S
F
Q
R
H
L
N
I
Q
Q
Y
P
A
I
P
L
S
P
K
T
G
L
L
G
W
V
P
N
S
D
T
F
H
V
L
I
--------
R
E
H
R
E
A
S
K
I
P
L
N
I
E
H
R
I
M
L
Q
M
A
-----
P
D
Y
D
N
L
T
L
L
Q
K
V
E
V
F
T
Y
A
L
D
N
T
K
G
Q
D
L
Y
K
V
L
W
L
K
S
R
--
S
S
----
E
S
W
L
D
R
R
T
T
Y
T
R
S
L
A
V
M
S
M
V
G
Y
I
L
G
L
G
D
R
H
P
S
N
L
M
L
D
R
I
T
G
K
V
V
H
I
D
F
G
D
C
F
E
A
A
I
L
R
E
-
K
Y
P
E
K
V
P
F
R
L
T
R
M
L
T
Y
A
M
E
V
S
G
I
--
E
-------
G
-----
S
----
F
R
I
T
C
E
N
V
M
M
V
L
R
D
N
K
E
S
L
M
A
I
L
E
A
F
A
Y
D
---
P
L
I
N
W
G
F
D
L
P
T
H
A
V
M
E
Q
T
G
I
D
L
P
L
A
N
P
S
--------
E
L
L
R
K
G
V
I
S
V
E
D
A
A
K
M
E
-------------------------------
L
Q
Q
K
A
E
V
R
N
A
R
A
T
L
V
L
K
R
I
A
D
K
L
T
G
N
D
F
P
R
C
Q
E
-----------------------------------------------------------
L
S
V
P
D
Q
V
D
K
L
I
Q
Q
A
T
S
V
E
N
L
C
Q
H
Y
I
-
G
W
C
S
--
50
HHSearch
43.95
10%
-50
- C2 -
-
4FDD
-
TNPO1_HUMAN
A:
[12-825]
---------------------------
L
Q
Q
I
L
Q
L
L
K
E
-
S
Q
S
P
D
T
T
I
Q
R
T
V
Q
Q
K
L
E
Q
L
N
-----------
Q
--
Y
--
P
D
F
N
N
Y
L
I
F
V
L
-
T
KLK--
S
--
E
D
E
P
T
R
S
L
S
G
L
I
L
K
N
N
V
K
A
H
-----------
F
-----------
Q
N-
F
P
N
G
V
T
D
F
I
K
S
E
C
L
N
-
N
I
G
D
S
S
P
L
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R
A
T
V
G
I
L
I
T
T
I
A
S
K
G
E
-----------
L
Q
N
W
P
D
L
L
P
K
L
C
S
L
L
D
S
-----
E
D
Y
N
T
C
E
G
A
F
G
A
L
Q
K
I
C
E
---
D
S
A
E
I
LDSDV
L
----
D
R
P
L
-
N
I
M
I
P
K
F
L
Q
F
F
K
H
--
S
--
S
P
K
I
R
S
H
A
---
V
--------
A
C
V
N
Q
F
I
I
S
R
T
Q
A
L
--
M
-
L
--
H
I
D
S
F
I
E
N
L
F
A
L
A
----
G
D
--------------------
E
E
P
------------------
E
--
V
R
K
-
N
V
C
R
A
L
V
M
L
--------
L
--
E
V
R
M
D
R
L
L
----
P
--
H
-
M
H
N
I
V
E
Y
M
L
-
Q
R
-
T
Q
D
--
Q
D
-
E
N
V
A
L
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A
C
E
F
W
L
T
L
A
E
Q
P
I
C
K
D
V
L
V
-------------
R
H
L
P
K
L
I
P
V
L
V
N
G
M
K
Y
---------------------------
S
-
D
I
D
I
I
-
L
L
K
G
----------------
S
D
-
W
N
L
R
---
K
C
S
A
A
A
L
D
V
L
A
N
V
-------------------------------------------
Y
R
D
-
E
L
L
P
H
I
L
P
L
L
K
E
L
L
-
F
-
H
-
H
E
W
V
V
K
E
S
G
I
L
V
L
G
A
I
A
E
G
C
M
Q
G
-----------------
M
I
P
Y
L
P
E
L
I
P
H
L
I
-
Q
C
L
S
-----------
D
K
K
A
L
V
R
S
I
T
C
W
T
L
S
-
R
Y
A
H
W
V
V
--------
S
QPPDTY
L
K
P
L
M
T
E
L
L
K
R
I
L
D
-
S
N
K
-------
R
V
Q
E
A
A
C
S
A
F
A
T
L
E
E
-
E
A
C
-
T
-------
E
L
V
P
Y
L
A
Y
I
L
D
T
L
V
F
A
F
S
-
K
--
Y
Q
---
H
K
N
L
L
I
L
--
Y
-----
D
A
I
G
T
L
A
D
S
V
G
H
H
L
-
N
K
P
E
Y
I
Q
---
M
L
M
P
P
L
I
Q
K
W
N
-
M
L
-------------
K
D
---------------------------------
E
----
D
K
D
L
F
P
L
L
E
C
L
S
S
V
A
T
-
A
L
Q
S
G
F
L
P
Y
C
E
P
V
Y
Q
R
C
V
-
N
L
V
Q
-
K
T
L
A
Q
A
M
L
N
N
A
QPDQYEA
P
-
D
K
D
F
M
I
V
A
L
D
L
L
S
G
L
A
E
G
L
G
G
N
-----
I
--
E
--
Q
L
V
A
R
S
N
I
L
T
L
M
Y
Q
C
M
Q
D
---
K
M
P
E
V
-
R
Q
S
S
F
-
A
L
L
G
D
L
-----
T
K
A
C
F
Q
H
V
K
P
-------------------------------------
C
I
--
A
D
F
M
P
I
L
G
-
T
N
L
N
-----------------
P
-----------------
E
F
--
I
S
-
V
C
N
N
A
T
W
A
I
G
E
I
S
I
Q
M
G
I
E
--
M
-
Q
P
Y
I
P
--
M
V
L
H
Q
L
V
E
I
I
N
R
P
N
T
-----------
P
K
----------
T
L
L
E
N
T
A
I
T
I
G
R
---
L
G
Y
V
C
P
---
Q
-----
E
V
A
--
P
M
L
Q
-
Q
F
I
R
P
W
C
T
S
L
R
N
----
I
R
--------------
D
N
E
E
K
D
S
A
F
R
G
I
C
T
M
I
S
V
N
-
P
S
-
G
-
V
I
-
Q
D
F
-
I
F
F
C
D
A
V
A
S
W
I
N
-----
P
-----
K
--
D
-
D
-
L
R
D
M
F
C
K
I
L
H
G
F
K
N
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
HHSearch
40.43
10%
-52
- C2 -
-
3W3U
-
IMB3_YEAST
A:
[136-1064]
---------------------------------------------------------------------
A
--
W
--
P
E
L
L
Q
A
L
I
E
S
L
-
K
-----
S
--
G
N
P
N
F
R
E
S
S
F
R
I
L
T
T
V
P
Y
L
I
-----------
T
----------------
A
V
D
I
N
S
I
L
P
I
F
Q
S
-
G
F
T
D
A
S
D
N
V
K
I
A
A
V
T
A
F
V
G
Y
F
K
Q
L
P
K
S
E
WSK
L
G
I
L
L
P
S
L
L
N
S
L
P
R
F
L
----
D
D
-----
G
K
D
D
A
L
A
S
V
F
E
S
L
I
E
L
V
E
---
L
A
P
K
L
-----
F
----
K
D
M
F
-
D
Q
I
I
Q
F
T
D
M
V
I
K
N
KD
L
--
E
P
P
A
R
T
T
A
---
L
E
--------
L
L
T
V
F
S
E
N
A
P
Q
M
C
K
S
N
-
Q
N
-
Y
G
Q
T
L
V
M
V
T
L
I
M
M
----
T
E
VSIDDDDA
A
E
W
I
E
SDDTDDE
E
-
E
------------------
V
--
T
Y
D
-
H
A
A
A
A
L
A
R
V
--------
A
--
L
K
L
G
---
G
----
E
Y
-
L
-
A
A
P
L
F
Q
Y
L
Q
-
Q
M
-
I
T
S
--
T
E
-
W
R
E
R
F
A
A
M
M
A
L
S
S
A
A
A
G
C
A
--
D
V
L
I
-------------
G
E
I
P
K
I
L
D
M
V
I
P
L
I
N
D
--------------------------
P
H
P
R
V
Q
Y
G
-
C
C
K
V
L
G
Q
I
S
T
A
F
------
S
P
F
I
-------------------
Q
R
----------------------------------
T
-------------
A
H
D
R
I
L
P
A
L
I
S
K
L
-
T
S
E
-
C
T
S
R
V
Q
T
H
A
A
A
A
L
V
A
F
S
E
F
A
S
K
D
----------------
I
L
E
P
Y
L
D
S
L
L
T
N
L
L
-
V
L
L
Q
-----------
S
N
K
L
Y
V
Q
E
Q
A
L
T
T
I
A
-
F
I
A
E
A
A
K
NKFIKY--
Y
-------
D
T
L
M
P
L
L
L
N
V
L
K
V
N--
S
-------
V
L
K
G
K
C
M
E
C
A
T
L
I
G
F
-
A
V
G
-
K
E
------
K
F
H
E
H
S
Q
E
L
I
S
I
L
V
A
L
Q
N
-
S
DI
D
E
D
--
D
A
L
R
S
Y
L
--
E
-----
Q
S
W
S
R
I
C
R
I
L
G
D
D
F
-
V
P
LL--
P
---
I
V
I
P
P
L
L
I
T
A
K
-
A
T
-------------
Q
D
VGLIEEEEAANFQQYPD
W
D
V
V
Q
V
QG
K
H
I
A
I
H
T
S
V
----
L
D
D
K
V
S
A
M
E
L
L
Q
S
Y
A
T
-
L
L
R
G
Q
F
A
V
Y
V
K
E
V
M
E
E
I
A
L
P
S
L
D
F
Y
-----------------
L
-
H
D
G
V
R
A
A
G
A
T
L
I
P
I
L
L
S
C
L
L
A
A
E
E
---
L
--
V
--
L
L
W
H
--
K
A
S
S
K
L
I
G
G
L
M
S
E
--
P
M
P
E
I
-
T
Q
V
Y
H
-
N
S
L
V
N
G
-----
I
K
V
M
G
D
N
C
L
S
-
E
D
Q
L
A
A
F
T
-----------
K
G
V
S
A
N
L
T
D
T
Y
E
R
M
Q
D
R
----
D
E
Y
N
E
-------------------------
F
-----------------
T
D
--
E
D
-
L
L
D
E
I
N
K
S
I
A
A
V
L
K
T
T
N
G
H
--
Y
-
L
K
N
L
E
--
N
I
W
P
M
I
N
T
F
L
L
D
N
-
E
------------
P
----------
I
L
V
I
F
A
L
V
V
I
G
D
---
L
I
Q
Y
G
G
---
E
-----
Q
T
A
--
S
M
K
N
-
A
F
I
P
K
V
T
E
C
L
I
S
----
P
D
---------------
A
R
I
R
Q
A
A
S
Y
I
I
G
V
C
A
Q
Y
A
-
P
S
-
T
-
Y
A
-
D
V
C
-
I
P
T
L
D
T
L
V
Q
I
V
D
PGSKL
E
-----
E
--
N
R
S
-
S
T
E
N
A
S
A
A
I
A
K
I
L
Y
A
Y
-------
V
D
T
Y
T
A
N
W
F
K
T
L
P
-
T
I
T
-
D
K
----------
E
A
A
S
F
N
Y
Q
F
L
S
Q
L
-------
I
E
N
N
S
---
Q
--
S
N
I
S
A
V
V
D
S
V
--
I
Q
A
L
N
E
R
----
S
L
T
------
V
I
S
S
V
K
K
L
L
G
F
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
Fugue
40.25
57%
-121
* C1 *
-
1W1N
-
A:
[1-33]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
L
D
V
P
E
Q
V
D
K
L
I
Q
Q
A
T
S
I
E
R
L
C
Q
H
Y
-
I
G
W
C
P
F
W
57
HHSearch
39.09
10%
-25
- C2 -
-
4FDD
-
TNPO1_HUMAN
A:
[22-826]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
S
P
D
T
T
I
Q
R
T
V
Q
Q
K
L
E
Q
L
N
Q
Y
-
P
--------
D
F
N
-
N
Y
L
I
F
V
L
T
K
L
----
K
S
-----
E
D
E
P
T
R
S
L
S
G
L
I
L
K
N
N
V
K
---
A
H
F
Q
N
-----
F
----
P
N
G
V
T
D
F
I
K
S
E
C
L
N
N
I
G
D
--
S
--
S
P
L
I
R
A
T
V
---
G
--------
I
L
I
T
T
I
A
S
K
G
E
L
Q
--------
N
W
P
D
L
L
P
K
L
C
S
L
L
----
D
S
--------------------
E
D
Y
------------------
N
--
T
C
E
-
G
A
F
G
A
L
Q
K
I
--------
C
--
E
D
S
A
E
I
L
D
SDVL
D
R
-
P
-
L
N
I
M
I
P
K
F
L
-
Q
F
-
F
K
H
--
S
S
-
P
K
I
R
S
H
A
V
A
C
V
N
Q
F
I
I
S
R
T
--
Q
A
L
M
-------------
L
H
I
D
S
F
I
E
N
L
F
A
L
A
G
D
E
-------------------------
E
P
-
E
V
R
K
N
-
V
C
R
A
L
V
M
L
L
E
V
R
------
M
D
R
L
--------
L
P
-----------------------------------------------------------
H
M
H
N
I
V
E
Y
M
L
Q
R
T
-
Q
-
D
-
Q
D
E
N
V
A
L
E
A
C
E
F
W
L
T
L
A
E
Q
P
I
C
K
---------------
D
V
L
V
R
H
L
P
K
L
I
P
V
L
V
N
-
G
M
K
YS
D
I
D
I
I
L
L
K
G-
S
D
W
N
L
R
K
C
S
A
A
A
L
D
-
V
L
A
N
V
Y
R
DEL-----
L
-------
P
H
I
L
P
L
L
K
E
L
L
F
H
-
H
E
W
-------
V
V
K
E
S
G
I
L
V
L
G
A
I
A
E
-
G
C
M
-
Q
-------
G
M
I
P
Y
L
P
E
L
I
P
H
L
I
Q
C
L
S
-
D
--
K
-
K
--
A
L
V
R
S
I
T
--
C
-----
W
T
L
S
R
Y
A
H
W
V
V
S
Q
P
P
D
T
Y
L
--
K
---
P
L
M
T
E
L
L
K
R
I
L
----------------
D
S
---------------------------------
N
----
K
R
V
Q
E
A
A
C
S
A
F
A
T
L
E
E
-
E
A
C
T
E
L
V
P
Y
L
A
Y
I
L
D
T
L
V
-
F
A
F
S
-
K
-----------------
Y
-
Q
H
K
N
L
L
I
L
Y
D
A
I
G
T
L
A
D
S
V
G
H
H
-----
L
NK
P
--
E
Y
I
Q
--
M
L
M
P
P
L
I
Q
K
W
N
M
L
-
K
D
E
D
K
D
-
L
F
P
L
L
-
E
C
L
S
S
V
-----
A
T
A
L
Q
S
G
F
L
P
Y
C
---------------------------------------
E
P
V
Y
Q
R
C
V
-
N
L
V
Q
-----------------
K
T
L
A
Q
A
M
L
N
N
A
QPDQYEA
P
D
--
K
D
-
F
M
I
V
A
L
D
L
L
S
G
L
A
E
G
L
G
G
N
--
I
-
E
Q
L
V
A
R
S
N
I
L
T
L
M
Y
Q
C
M
Q
D
K
-------------
M
P
----------
E
V
R
Q
S
S
F
A
L
L
G
D
---
L
T
K
A
C
F
---
Q
-----
H
V
K
--
P
C
I
A
-
D
F
M
P
I
L
G
T
N
L
N
P
----
E
F
---------------
I
S
V
C
N
N
A
T
W
A
I
G
E
I
S
I
Q
M
-
G
I
-
E
-
M
Q
-
P
Y
I
-
P
M
V
L
H
Q
L
V
E
I
I
N
-----
R
-----
P
NT
P
K
T
-
L
L
E
N
T
A
I
T
I
G
R
L
G
Y
V
C
P
Q
E
V
A
P
M
L
Q
Q
F
I
R
P
W
C
T
S
L
R
-
N
-
I
R
D
N
----------
E
E
K
D
S
A
F
R
G
I
C
T
M
-------
I
S
V
N
P
S
G
V
I
--
Q
D
F
I
F
F
C
D
A
V
--
A
S
W
I
N
P
K
------
D
-
D
L
R
D
M
F
C
K
I
L
H
G
F
K
N
Q
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
HHSearch
38.77
13%
-13
- C2 -
-
4XRI
9
?
A:
[10-871]
----------------------------
P
D
I
N
I
I
L
E
N
-
S
L
S
P
D
A
T
L
R
H
A
A
E
Q
Q
L
T
H
A
A
-----------
E
T
N
F
--
S
Q
Y
L
L
T
L
V
Q
A
L
-
A
-----
N
ES
S
E
G
H
I
R
A
A
A
G
I
A
L
K
N
A
F
S
A
R
-----------
E
F
A
R
Q
A
A
L
Q
A
K
W
L
NQ
T
D
Q
E
T
R
T
R
V
K
Q
L
A
L
E
-
T
L
A
S
P
N
S
K
A
G
Q
A
A
A
Q
V
I
A
A
I
A
A
I
----------
E
L
P
R
N
Q
W
P
E
L
M
H
A
L
----
V
R
N
A
S
E-
G
G
Q
H
Q
K
Q
A
S
L
T
A
I
G
F
I
C
E
---
T
Q
D
T
D
-----
L
R
N
S
L
V
G
H
S
-
N
A
I
L
T
A
V
V
Q
G
A
R
K
EE
P
--
N
N
E
V
R
F
A
A
---
I
--------
T
A
L
G
D
S
L
E
F
V
G
N
N
F
--
K
-
H
E
G
E
R
N
Y
I
M
Q
V
V
C
E
A
T
----
Q
A
--------------------
Q
D
S
------------------
R
--
I
Q
Q
-
G
A
F
G
C
L
N
R
I
--------
M
--
A
L
Y
Y
E
H
M
R
----
Y
--
Y
-
M
E
K
A
L
F
G
L
T
I
L
G
-
M
K
S
--
D
D
-
E
D
V
A
K
L
A
V
E
F
W
S
T
V
C
E
E
E
I
--
A
I
E
D
---
D
N
--
A
Q
V
E
S
S
E
Q
M
R
P
F
Y
N
F
A
R
V
A
--------------------
T
N
----------
E
V
V
P
V
-
L
L
Q
L
L
T
K
Q
D
E
D
A
------
S
D
D
E
-
Y
N
I
S
R
A
A
Y
Q
C
L
Q
L
Y
A
Q
A
V
G
S
-----------------------------------------------
T
I
I
P
P
V
I
Q
F
V
E
H
N
L
-
R
-
H
-
A
D
W
H
F
R
D
A
A
V
S
A
F
G
A
I
M
D
G
P
E
E
K
----------------
V
L
E
P
I
V
K
T
G
M
Q
P
L
I
-
A
M
M
E
-----------
D
E
S
I
Q
V
R
D
S
T
A
Y
A
L
G
-
R
I
T
E
A
C
S
EAIDPNTH
L
-------
E
P
L
I
R
S
L
F
N
G
L
M
N
--
S
P
-------
K
M
A
A
S
C
C
W
A
L
M
N
I
A
E
-
R
F
A
-
G
EPGAAQN
P
L
T
P
H
F
N
Q
S
V
T
N
L
L
T
V
T
A
P
M
--
N
G
D
--
S
T
V
R
T
A
A
--
Y
-----
E
V
L
S
V
F
V
Q
N
A
A
N
D
S
-
L
S
A
V
--
A
---
S
L
S
T
V
I
L
Q
R
L
E
-
E
T
-------------
L
P
L
Q
Q
Q
VVS
V
E
------------------------
D
K
L
I
L
E
D
M
Q
T
S
L
C
T
V
L
Q
A
T
V
Q
-
R
L
D
K
E
I
A
P
Q
G
D
R
I
M
Q
V
L
L
-
Q
I
L
S
-
T
CG---------------
G
-
K
S
S
V
P
E
G
V
F
A
A
I
S
A
L
A
N
A
M
E
E
E
-----
F
--
A
--
K
Y
M
E
--
A
F
A
P
F
L
Y
N
A
L
G
N
Q
--
E
E
P
S
L
-
C
S
M
A
I
-
G
L
V
S
D
V
-----
T
R
S
L
G
E
R
S
Q
------------------------------------
P
-
Y
C
--
D
N
F
M
N
Y
L
L
-
G
N
L
R
-----------------
S
TT---------------
L
A
--
N
Q
-
F
K
P
A
I
L
Q
C
F
G
D
I
A
S
A
I
G
G
H
--
F
-
E
T
Y
L
T
--
I
V
A
Q
V
L
Q
Q
A
A
T
I
T
-
A
GPDGS
Y
E
M
I
D
Y
V
I
----------
S
L
R
E
G
I
M
D
A
W
G
G
---
I
I
G
A
M
K
---
T
S
NKTN
V
L
Q
--
P
Y
V
E
-
S
I
F
A
L
L
N
S
I
A
N
D
----
P
N
-------------
R
S
E
A
L
M
R
A
S
M
G
V
I
G
D
L
A
D
A
Y
-
P
N
-
G
Q
L
A
D
A
F
R
-
Q
D
W
I
T
A
M
I
R
E
T
R
-----
S
NREF-
G
--
A
-
R
-
T
I
E
T
A
R
W
A
R
E
Q
V
K
R
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
HHSearch
37.23
25%
-76
- C1 -
-
5C46
-
PI4KB_HUMAN
E:
[285-488]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
-----
W
------
R
L
-----
L
S
V
I
V
K
C
G
D
D
L
R
Q
E
L
L
A
F
Q
V
L
K
Q
L
Q
S
I
W
E
Q
E
----
R
V
P
L
W
I
K
P
Y
K
I
L
V
I
S
A
D
S
G
M
I
E
P
V
V
N
A
V
S
I
H
Q
V
K
--------
K
Q
S
Q
-----------------------------------------------
L
S
L
L
D
Y
F
L
Q
E
H
G
SY
T
T
----
E
A
F
L
S
A
Q
R
N
F
V
Q
S
C
A
G
Y
C
L
V
C
Y
L
L
Q
V
K
D
R
H
N
G
N
I
L
L
-
D
A
E
G
H
I
I
H
I
D
F
G
F
I
L
S
S
S
P
---------
S
A
F
K
L
T
T
E
F
V
D
V
M
G
--
G
L
--
D
-------
G
-----
D
MFNY
Y
K
M
L
M
L
Q
G
L
I
A
A
R
K
H
M
D
K
V
V
Q
I
V
E
I
M
Q
Q
G
---
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
HHSearch
36.99
12%
-26
- C2 -
-
3W3W
-
IMB3_YEAST
A:
[9-983]
---------------------------
N
R
T
L
L
Q
I
V
Q
A
-
F
A
S
-
D
N
Q
I
R
S
V
A
E
K
A
L
S
E
E
W
-----------
I
--
T
--
E
N
N
I
E
Y
L
L
T
F
L
-
A
E
Q
A
A
F
S
--
Q
D
T
T
V
A
A
L
S
A
V
L
F
R
K
L
A
L
K
A
P----------
I
-----------
T
H-
I
R
K
E
V
L
A
Q
I
R
S
S
L
L
K
G
F
L
S
E
R
A
D
S
I
R
H
K
L
S
D
A
I
A
E
C
V
Q
D
----------
D
L
P
--
A
W
P
E
L
L
Q
A
L
----
I
E
S
L
K
S-
G
N
P
N
F
R
E
S
S
F
R
I
L
T
T
V
P
Y
---
L
I
-
T
-----------
A
V
D
I
-
N
S
I
L
P
I
F
Q
S
G
F
T
D
--
A
--
S
D
N
V
K
I
A
A
---
V
T
A
F
--------
V
G
Y
F
K
Q
L
P
K
S
E
--
W
-
S
--
K
L
G
I
L
L
P
S
L
L
N
S
L
P
R
F
L
D
D
G-------------------
K
-
D
------------------
D
--
A
L
A
-
S
V
F
E
S
L
I
E
L
--------
V
--
E
L
A
P
K
L
F
K
----
D
--
M
-
F
D
Q
I
I
Q
F
T
D
-
M
V
-
I
K
N
KD
L
E
-
P
P
A
R
T
T
A
L
E
L
L
T
V
F
S
E
N
A
P
--
Q
M
C
K
---------
S
N
Q
-
N
Y
G
Q
T
L
V
M
V
T
L
I
M
M
T
E
---------------------------
V
-
S
I
D
D
D
D
A
A
E
W
I
E
S
D
D
T
D
D
------
E
E
E
V
T
Y
D
H
A
---
R
Q
A
L
D
R
V
A
L
----------------------------------------------
K
L
G
G
E
Y
L
A
A
P
L
F
Q
Y
L
Q
Q
M
I
-
T
-
S
-
T
E
W
R
E
R
F
A
A
M
M
A
L
S
S
A
A
E
G
C
A
D
V
-----------------
L
I
G
E
I
P
K
I
L
D
M
V
I
-
P
L
I
N
-----------
D
P
H
P
R
V
Q
Y
G
C
C
N
V
L
G
-
Q
I
S
T
D
F
S
--------
P
F
I
Q
R
T
A
H
D
R
I
L
P
A
L
I
S
K
L
T
S
E
C
T
S
-------
R
V
Q
T
H
A
A
A
A
L
V
N
F
S
E
-
F
A
S
-
K
D------
I
L
E
P
Y
L
D
S
L
L
T
N
L
L
V
L
L
Q
-
S
--
N
-
K
--
L
Y
V
Q
E
Q
A
--
L
-----
T
T
I
A
F
I
A
E
A
A
K
N
K
F
-
I
K
YY--
D
---
T
L
M
P
L
L
L
N
V
L
K
-
V
N
-----------------------------------------------------
S
V
L
K
G
K
C
M
E
C
A
T
L
I
G
F
A
V
G
K
E
K
F
H
E
H
S
Q
E
L
I
S
I
L
V
-
A
L
Q
N
S---------------------
D
A
L
R
S
Y
L
E
Q
S
W
S
R
I
C
R
I
L
G
D
D
-----
F
--
V
--
P
L
L
P
--
I
V
I
P
P
L
L
I
T
A
K
A
T
--
Q
D
V
G
L
-
I
E
E
E
E
A
A
N
F
Q
Q
Y
PD
W
D
V
V
Q
V
Q
G
K
H
I
A
I
H
T
S
V
L
D
D
K
-----------
V
S
A
M
E
L
L
Q
S
Y
A
T
L
L
R
G
Q
F
A
V
Y
V
K
E
V
M
E
E
I
A
L
P
S
L
D
F----------------
Y
-----------------
L
H
--
D
G
-
V
R
A
A
G
A
T
L
I
P
I
L
L
S
C
L
L
A
A
E
E
L
-
V
L
L
W
H
--
K
A
S
S
K
L
I
G
G
L
M
S
E
-
P
-----------
M
P
----------
E
I
T
Q
V
Y
H
N
S
L
V
N
---
G
I
K
V
M
G
---
D
-----
N
C
L
S
E
D
Q
L
A
-
A
F
T
K
G
V
S
A
N
L
T
D
----
T
Y
E
R
M
Q
DRDEYNED
F
T
D
E
D
L
L
D
E
I
N
K
S
I
A
A
V
L
K
T
T
-
N
G
-
H
-
Y
L
-
K
N
L
-
E
N
I
W
P
M
I
N
T
F
L
L
--------------
E
-
P
I
L
V
I
F
A
L
V
V
I
G
D
L
I
Q
Y
--
E
Q
T
A
S
M
K
N
A
F
I
P
K
V
T
E
C
L
I
-
S
-
P
-
D
A
----------
R
I
R
Q
A
A
S
Y
I
I
G
V
C
-------
A
Q
Y
A
P
S
T
Y
A
--
D
V
C
I
P
T
L
D
T
L
--
V
Q
I
V
D
--GSKL
E
E
N
R
S
S
T
E
N
A
S
A
A
I
A
K
I
L
Y
A
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
HHSearch
36.98
12%
-18
* C2 *
-
2BPT
-
?
A:
[4-835]
----------------------------
A
E
F
A
Q
L
L
E
N
S
I
L
S
P
D
Q
N
I
R
L
T
S
E
T
Q
L
K
K
L
S
-----------
N
--
D
N
F
L
Q
F
A
G
L
S
S
Q
V
L
I
D
E----
N
--
T
K
L
E
G
R
I
L
A
A
L
T
L
K
N
E
L
V
S
K
D
S
V
K
T
Q
Q
F
A
Q
R
W
-----------
I
TQ
V
S
P
E
A
K
N
Q
I
K
T
N
A
L
T
-
A
L
V
S
I
E
P
R
I
A
N
A
A
A
Q
L
I
A
A
I
A
D
I
----------
E
L
P
H
G
A
W
P
E
L
M
K
I
M
----
V
D
N
T
GAE
Q
P
E
N
V
K
R
A
S
L
L
A
L
G
Y
M
C
E
---
S
A
D
P
Q
SQA--
L
----
V
S
S
S
-
N
N
I
L
I
A
I
V
Q
G
A
Q
S
--
T
ET
S
K
A
V
R
L
A
A
---
L
--------
N
A
L
A
D
S
L
I
F
I
K
N
N
M
--
E
R
E
G
-
E
R
N
Y
L
M
Q
V
V
C
E
A
T
----
Q
A
--------------------
E
D
I
------------------
E
--
V
Q
A
-
A
A
F
G
C
L
C
K
I
--------
M
--
S
K
Y
Y
T
F
M
K
----
P
--
Y
-
M
E
Q
A
L
Y
A
L
T
-
I
A
T
M
K
S
--
P
N
-
D
K
V
A
S
M
T
V
E
F
W
S
T
I
C
E
E
E
I
--
D
I
A
Y
E
L
A
----------
Q
F
P
Q
S
P
L
Q
S
Y
N
F
A
L
S
S
-----------------
I
K
----------
D
V
V
P
N
-
L
L
N
L
L
T
R
Q
N
E
D
-------
E
D
D
D
-
W
N
V
S
---
M
S
A
G
A
C
L
Q
L
F
A
Q
N
-------------------------------------------
C
G
N
-
H
I
L
E
P
V
L
E
F
V
E
Q
N
I
-
T
-
A
-
D
N
W
R
N
R
E
A
A
V
M
A
F
G
S
I
M
D
G
P
D
K
V
----------------
Q
R
T
Y
Y
V
H
Q
A
L
P
S
I
L
-
N
L
M
N
-----------
D
Q
S
L
Q
V
K
E
T
T
A
W
C
I
G
-
R
I
A
D
S
V
A
ESIDPQQH
L
-------
P
G
V
V
Q
A
C
L
I
G
L
Q
D
--
H
P
-------
K
V
A
T
N
C
S
W
T
I
I
N
L
V
E
-
Q
L
A
-
E
ATPS---
P
I
Y
N
F
Y
P
A
L
V
D
G
L
I
G
A
A
N
-
R
I-
D
N
E
--
F
N
A
R
A
S
A
--
F
-----
S
A
L
T
T
M
V
E
Y
A
T
D
T
V
-
A
E
T
S
--
A
---
S
I
S
T
F
V
M
D
K
L
G
-
Q
T
M
S
VDENQLT
L
E
D
A
Q
S
---------------------------------
L
----
Q
E
L
Q
S
N
I
L
T
V
L
A
A
V
I
R
-
K
S
P
S
S
V
E
P
V
A
D
M
L
M
G
L
F
F
-
R
L
L
E
-
K
-----------------
K
D
S
A
F
I
E
D
D
V
F
Y
A
I
S
A
L
A
A
S
L
G
K
G
-----
F
--
E
--
K
Y
L
E
--
T
F
S
P
Y
L
L
K
A
L
N
Q
---
V
D
S
P
V
-
S
I
T
A
V
-
G
F
I
A
D
I
-----
S
N
S
L
E
E
D
F
R
------------------------------------
R
-
Y
S
--
D
A
M
M
N
V
L
A
-
Q
M
I
S
-----------------
N
-----------------
P
N
AR
R
E
-
L
K
P
A
V
L
S
V
F
G
D
I
A
S
N
I
G
A
D
--
F
-
I
P
Y
L
N
--
D
I
M
A
L
C
V
A
A
Q
N
T
K
-
P
-----------
E
N
GT
L
E
A
L
D
Y
Q
I
K
V
L
E
A
V
L
D
A
Y
V
G
---
I
V
A
G
L
H
DKP
E
-----
A
L
F
--
P
Y
V
G
-
T
I
F
Q
F
I
A
Q
V
A
E
D
PQLY
S
E
---------------
D
A
T
S
R
A
A
V
G
L
I
G
D
I
A
A
M
F
-
P
D
G
S
-
I
K
-
Q
F
Y
G
Q
D
W
V
I
D
Y
I
K
R
T
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
HHSearch
36.96
9%
-42
- C2 -
-
3W3W
-
IMB3_YEAST
A:
[125-1053]
---------------------------------------------------------------------
A
--
W
--
P
E
L
L
Q
A
L
I
E
S
L
-
K
-----
S
--
G
N
P
N
F
R
E
S
S
F
R
I
L
T
T
V
P
Y
L
I
-----------
T
----------------
A
V
D
I
N
S
I
L
P
I
F
Q
S
-
G
F
T
D
A
S
D
N
V
K
I
A
A
V
T
A
F
V
G
Y
F
K
Q
L
P
K
S
E
WSK
L
G
I
L
L
P
S
L
L
N
S
L
P
R
F
L
----
D
D
-----
G
K
D
D
A
L
A
S
V
F
E
S
L
I
E
L
V
E
---
L
A
P
K
L
-----
F
----
K
D
M
F
-
D
Q
I
I
Q
F
T
D
M
V
I
K
N
KD
L
--
E
P
P
A
R
T
T
A
---
L
E
L
L
--------
T
V
F
S
E
N
A
P
Q
M
C
K
S
N
-
Q
N
-
Y
G
Q
T
L
V
M
V
T
L
I
M
M
----
T
E
--------------------
V
-
S
IDDDDA
A
E
W
I
E
SDDTDDE
E
E
V
T
Y
D
-
H
A
R
Q
A
L
D
R
V
--------
A
--
L
K
L
G
G
E
Y
--------
L
-
A
A
P
L
F
Q
Y
L
Q
-
Q
M
-
I
T
S
--
T
E
-
W
R
E
R
F
A
A
M
M
A
L
S
S
A
A
E
G
C
A
--
D
V
L
I
-------------
G
E
I
P
K
I
L
D
M
V
I
P
L
I
N
D
--------------------------
P
H
P
R
V
Q
Y
G
-
C
C
N
V
L
G
Q
I
S
T
D
F
------
S
P
F
I
----
Q
---
R
T
-----------------------------------------------------------
A
H
D
R
I
L
P
A
L
I
S
K
L
-
T
-
S
E
C
T
S
R
V
Q
T
H
A
A
A
A
L
V
N
F
S
E
F
A
S
K
D
----------------
I
L
E
P
Y
L
D
S
L
L
T
N
L
L
-
V
L
L
Q
-----------
S
N
K
L
Y
V
Q
E
Q
A
L
T
T
I
A
-
F
I
A
E
A
A
K
NKFIKY--
Y
-------
D
T
L
M
P
L
L
L
N
V
L
K
V
N--
S
-------
V
L
K
G
K
C
M
E
C
A
T
L
I
G
F
-
A
V
G
K
E
-------
K
F
H
E
H
S
Q
E
L
I
S
I
L
V
A
L
Q
N
-
S
-------
D
A
L
R
S
Y
L
--
E
-----
Q
S
W
S
R
I
C
R
I
L
G
D
D
F
-
V
P
LL--
P
---
I
V
I
P
P
L
L
I
T
A
K
-
A
T
-------------
Q
D
VGLIEEEEAANFQQYPD
W
D
V
V
Q
V
QG
K
H
I
A
I
H
T
S
V
----
L
D
D
K
V
S
A
M
E
L
L
Q
S
Y
A
T
-
L
L
R
G
Q
F
A
V
Y
V
K
E
V
M
E
E
I
A
L
P
S
L
D
F
Y
-----------------
L
-
H
D
G
V
R
A
A
G
A
T
L
I
P
I
L
L
S
C
L
L
A
A
E
E
---
L
--
V
--
L
L
W
H
--
K
A
S
S
K
L
I
G
G
L
M
S
E
--
P
M
P
E
I
-
T
Q
V
Y
H
-
N
S
L
V
N
G
-----
I
K
V
M
G
D
N
C
L
S
-
E
D
Q
L
A
A
F
T
-----------
K
G
V
S
A
N
L
T
D
T
Y
E
R
M
Q
D
R
----
D
E
Y
N
E
-------
D
-----------------
F
-----------------
T
D
--
E
D
-
L
L
D
E
I
N
K
S
I
A
A
V
L
K
T
T
N
G
H
--
Y
-
L
K
N
L
E
--
N
I
W
P
M
I
N
T
F
L
L
---
E
------------
P
----------
I
L
V
I
F
A
L
V
V
I
G
D
---
L
I
Q
Y
-----
E
-----
Q
T
A
--
S
M
K
N
-
A
F
I
P
K
V
T
E
C
L
I
S
----
P
D
---------------
A
R
I
R
Q
A
A
S
Y
I
I
G
V
C
A
Q
Y
A
-
P
S
-
T
-
Y
A
-
D
V
C
-
I
P
T
L
D
T
L
V
Q
I
V
D
------GSKLE
E
--
N
-
R
S
S
T
E
N
A
S
A
A
I
A
K
I
L
Y
A
Y
N
S
N
I
P
---
D
T
Y
T
A
N
W
F
K
T
L
P
T
I
-
T
-
D
K
----------
E
A
A
S
F
N
Y
Q
F
L
S
Q
---------------
V
C
AQ
S
N
I
S
A
V
V
D
S
V
--
I
Q
A
L
N
E
R
----
S
L
T
------
V
I
S
S
V
K
K
L
L
G
F
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
Fugue
34.61
19%
-50
- C1 -
-
4D0L
2
PI4KB_HUMAN
A:
[10-566]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
L
L
R
L
F
E
S
K
L
F
D
I
S
M
A
I
S
Y
L
Y
--
N
S
K
E
P
G
V
Q
A
Y
I
G
N
R
L
F
C
F
R
N
E
D
V
D
F
Y
------
L
P
Q
L
L
N
M
Y
I
H
M
D
E
D
V
G
D
A
I
K
P
Y
I
V
H
R
C
R
Q
S
---------------------------
I
N
F
S
L
Q
C
A
L
L
L
G
A
---
Y
S
S
---
R
G
T
K
L
R
K
L
I
L
S
R
L
A
P
E
R
E
F
-
I
K
S
L
M
A
I
G
K
R
L
A
T
L
P
T
K
E
Q
K
T
Q
R
L
I
S
E
L
S
-------
L
L
N
H
K
L
P
A
R
V
W
LPT
A
G
F
D
H
H
V
V
R
-
V
P
H
T
Q
A
V
V
L
N
S
K
D
K
A
P
Y
L
I
Y
V
E
V
L
E
C
E
N
F
D
T
T
S
V
P
A
R
I
P
E
N
P
S
A
-
V
-
A
L
K
E
P
W
Q
E
K
V
R
R
I
R
E
G
S
P
Y
-----
G
------
H
L
PN
W
R
L
L
S
V
I
V
K
C
G
D
D
L
R
Q
E
L
L
A
F
Q
V
L
K
Q
L
Q
S
I
W
E
Q
E
R
----
V
P
L
W
I
K
P
Y
K
I
L
V
I
S
A
D
S
G
M
I
E
P
V
V
N
A
V
S
------------------------------------------
I
H
Q
V
K
K
Q
S
Q
L
S
L
L
D
Y
F
L
Q
E
H
-----------
G
S
Y
--
T
T
----
E
A
F
L
S
A
Q
R
N
F
V
Q
S
C
A
G
Y
C
L
V
C
Y
L
L
Q
V
K
D
R
H
N
G
N
I
L
L
-
D
A
E
G
H
I
I
H
I
D
F
G
F
I
L
S
----------
S
S
S
A
F
K
L
T
T
E
F
V
D
V
M
G
G
L
D
G
--
D
-------
M
-----
F
N
Y
--
Y
K
M
L
M
L
Q
G
L
I
A
A
R
K
H
M
D
K
V
V
Q
I
V
E
I
M
Q
Q
G
SQL
P
C
F
H
G
S
-
S
T
I
R
N
L
K
E
R
F
H
M
S
M
T
E
E
Q
L
Q
L
L
V
E
Q
M
V
D
G
S
M
R
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
34.25
31%
-66
- C1 -
-
5NP0
-
ATM_HUMAN
A:
[2673-2989]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
P
T
M
E
----------
I
K
V
D
H
T
G
E
Y
G
N
-
L
V
T
I
Q
S
F
K
A
-
E
-
F
R
L
A
G
G
V
N
L
P
K
I
I
D
C
V
G
S
D
-----
G
------
K
E
-----
R
R
Q
L
V
K
G
R
D
D
L
R
Q
D
A
V
M
Q
Q
V
F
Q
M
C
N
T
L
L
Q
R
N
T
E
T
R
K
R
K
L
T
I
C
T
Y
K
V
V
P
L
S
Q
R
S
G
V
L
E
W
C
T
G
T
V
P
I
G
E
F
L
V
N
N
E
DGAH
K
R
Y
R
-
P
N
D
F
S
A
F
Q
C
Q
K
K
M
M
---
F
E
E
K
Y
E
V
F
M
D
V
C
Q
N
F
Q
P
V
F
R
Y
F
C
M
E
K
---------
F
L
D
P
----------
A
I
W
F
E
K
R
L
A
Y
T
R
S
V
A
T
S
S
I
V
G
Y
I
L
G
L
G
D
R
H
V
Q
N
I
L
I
N
E
Q
S
A
E
L
V
H
I
D
L
G
V
A
F
E
Q
G
K
I
L
P
-
T
-
P
E
T
V
P
F
R
L
T
R
D
I
V
D
G
M
G
I
T
G
V
--
E
-------
G
-----
V
----
F
R
R
C
C
E
K
T
M
E
V
M
R
N
S
Q
E
T
L
L
T
I
V
E
V
L
L
Y
D
---
P
L
F
D
W
T
M
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
HHSearch
32.41
9%
-41
- C2 -
-
1QBK
-
TNPO1_HUMAN
B:
[370-864]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
D
W
N
L
R
K
C
S
A
A
A
L
D
-
V
L
A
N
V
Y
R
DEL-----
L
-------
P
H
I
L
P
L
L
K
E
L
L
F
H
-
H
E
W
-------
V
V
K
E
S
G
I
L
V
L
G
A
I
A
E
-
G
C
M
-
Q
-------
G
M
I
P
Y
L
P
E
L
I
P
H
L
I
Q
C
L
S
-
D
--
K
-
K
--
A
L
V
R
S
I
T--
C
-----
W
T
L
S
R
Y
A
H
W
V
V
S
Q
P
P
D
T
YL--
K
---
P
L
M
T
E
L
L
K
R
I
L
----------------
D
S
---------------------------------
N
----
K
R
V
Q
E
A
A
C
S
A
F
A
T
L
E
E
-
E
A
C
T
E
L
V
P
Y
L
A
Y
I
L
D
T
L
V
-
F
A
F
S
-
K
-----------------
Y
-
Q
H
K
N
L
L
I
L
Y
D
A
I
G
T
L
A
D
S
V
G
H
H
-----
L
--
N
KP
E
Y
I
Q
--
M
L
M
P
P
L
I
Q
K
W
N
M
L
-
K
D
E
D
K
D
-
L
F
P
L
L
-
E
C
L
S
S
V
-----
A
T
A
L
Q
S
G
F
L
P
Y
C
---------------------------------------
E
P
V
Y
Q
R
C
V
-
N
L
V
Q
KTLAQAMLNNAQPDQYE
A
-----------------
P
D
--
K
D
-
F
M
I
V
A
L
D
L
L
S
G
L
A
E
G
L
G
G
N
--
I
-
E
Q
L
V
A
RS
N
I
L
T
L
M
Y
Q
C
M
Q
D
K
-------------
M
P
----------
E
V
R
Q
S
S
F
A
L
L
G
D
---
L
T
K
A
C
F
---
Q
-----
H
V
K
--
P
C
I
A
-
D
F
M
P
I
L
G
T
N
L
N
P
----
E
F
---------------
I
S
V
C
N
N
A
T
W
A
I
G
E
I
S
I
Q
M
-
G
I
-
E
-
M
Q
-
P
Y
I
-
P
M
V
L
H
Q
L
V
E
I
I
N
-----
R
-----
P
NT
P
K
T
-
L
L
E
N
T
A
I
T
I
G
R
L
G
Y
V
C
P
Q
E
V
A
P
M
L
Q
Q
F
I
R
P
W
C
T
S
L
R
-
N
-
I
R
D
N
----------
E
E
K
D
S
A
F
R
G
I
C
T
M
-------
I
S
V
N
P
S
G
V
I
--
Q
D
F
I
F
F
C
D
A
V
--
A
S
W
I
N
-------
P
K
D
D
L
R
D
M
F
C
K
I
L
H
G
F
K
N
Q
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
Fugue
32.23
11%
-13
- C2 -
-
1QGR
-
IMB1_HUMAN
A:
[1-876]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
L
I
T
I
L
E
K
T
V
--
S
P
--
D
-
R
--
L
E
L
E
A
A
Q
K
F
L
E
R
A
----
A
V
--------------------
E
-
N
------------------
L
--
P
-
T
-
F
L
V
E
L
S
R
V
L
A
NPGNS
Q
V
A
R
V
A
A
G
L
-
Q
I
K
----
N
S
L
T
S
K
D
P
D
I
K
A
Q
Y
-
Q
Q
-
R
W
L
--
A
I
D
A
N
A
R
R
E
V
K
N
Y
V
L
H
T
L
G
T
E
T
--
Y
R
P
S
S
A
S
Q
C
V
A
G
I
A
C
A
E
I
P
V
N
Q
W
P
E
L
I
P
Q
L
V
A
N
V
T
N
P
N
S
T
E
H
M
K
E
S
T
L
E
A
I
G
Y
I
C
Q
D
I
D
P
E
-
Q
L
Q
D
K
-
S
N
E
I
L
T
A
I
I
Q
G
M
RKEEPS
N
N
V
K
L
A
A
T
N
A
L
L
N
S
L
E
F
T
K
A
N
F
D
K
E
S
E
R
H
F
I
M
Q
V
V
C
E
A
T
Q
C
P
D
-----
T
R
V
R
V
A
A
L
Q
N
L
V
K
I
M
S
L
Y
Y
Q
Y
M
E
T
Y
M
G
P
A
L
-
F
A
I
T
I
E
A
M
K
-
S
-
D
I
D
E
V
A
L
Q
G
I
E
F
W
S
N
V
C
D
E
E
M
D
L
A
I
E
A
S
E
A
A
E
Q
G
R
P
P
E
H
T
S
K
F
Y
A
K
G
A
L
Q
Y
L
V
P
I
L
T
Q
T
L
T
KQ------
D
E
N
D
D
D
D
D
W
N
P
C
K
A
A
G
V
C
L
M
L
L
A
--------
T
-------
C
C
E
D
D
I
V
P
H
V
L
P
F
-
I
K
E
H
I
KNPD
W
R
Y
R
D
A
A
V
M
A
F
G
C
I
L
E
G
P
E
P
-
S
-------
Q
L
K
P
L
V
I
Q
A
M
P
T
L
I
E
L
M
K
-
D
--
P
S
V
V
V
R
D
T
A
A
W
---
T
-------
V
G
R
I
C
E
L
L
P
E
A
A
-
I
N
----
D
---
V
Y
L
A
P
L
L
Q
C
L
I
E
G
L
-------------
S
A
---------------------------------
E
----
P
R
V
A
S
N
V
C
W
A
F
S
S
L
A
E
A
A
Y
E
A
A
D
V
A
D
D
Q
E
E
P
A
T
Y
C
-
L
S
S
-------------------------
S
F
E
L
I
V
Q
K
L
L
E
T
T
D
R
P
D
G
H
-----
Q
--
N
--
N
L
R
S
--
S
A
Y
E
S
L
M
E
I
V
K
N
S
A
K
D
C
Y
P
A
-
V
Q
K
T
T
-
L
V
I
M
E
R
-----
L
Q
Q
V
L
Q
M
E
S
H
I
Q
S
T
S
D
R
I
Q
F
N
D
L
Q
S
L
L
C
A
T
L
Q
N
V
L
R
K
V
------
Q
H
Q
D
A
--
L
Q
I
S
D
V
V
M
-
A
S
L
L
-----------------
R
-----------------
M
F
--
S
G
G
V
Q
E
D
A
L
M
A
V
S
T
L
V
E
V
L
-
G
G
--
E
F
L
K
Y
M
E
--
A
F
K
P
F
L
G
I
G
L
K
N
Y
-
A
-----------
E
Y
----------
Q
V
C
L
A
A
V
G
L
V
G
D
L
C
R
A
L
Q
S
N
I
---
I
-----
P
F
C
--
D
E
V
M
Q
L
L
L
E
N
L
G
---------
N
E
------------
N
V
H
R
S
V
K
P
Q
I
L
S
V
F
G
D
I
A
L
A
I
-
G
--
G
-
E
F
-
K
K
Y
-
L
E
V
V
L
N
T
L
Q
Q
A
S
-----
Q
-----
A
--
Q
-
V
-
D
K
S
-----
D
Y
D
M
V
D
Y
L
N
E
L
R
E
S
C
L
E
A
Y
T
G
-
I
V
Q
G
L
K
-
G
-
D
-
Q
E
N
V
H
P
D
V
M
L
V
Q
P
R
V
E
F
I
L
S
F
I
D
H
I
A
G
DEDHT
D
G
V
-
V
A
C
A
A
--
G
L
I
G
D
L
C
T
A
F
G
K
D
V
L
K
L
V
E
----
A
R
P
-
M
I
H
E
L
L
T
E
G
R
R
S
K
T
N
K
A
K
T
L
A
R
W
A
T
K
E
L
R
K
L
K
N
Q
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
Fugue
31.54
26%
-50
- C1 -
-
1NSG
1
B:
[1-94]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
I
L
W
H
E
M
W
H
E
G
L
E
E
A
S
R
L
Y
F
G
E
---
R
N
V
K
G
M
F
E
V
L
E
P
L
H
A
M
M
E
R
G
P
Q
T
L
K
E
T
S
F
N
Q
A
Y
G
R
D
L
M
E
A
Q
E
W
C
R
K
Y
M
K
-------
S
G
N
V
K
D
L
T
Q
A
W
---
D
L
Y
Y
H
V
F
R
R
-
I
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
31.11
23%
-47
- C1 -
-
5KC2
-
VPS34_YEAST
C:
[584-821]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
D
V
L
I
C
D
V
C
P
-
E
T
S
K
V
F
K
S
S
L
S
P
L
K
I
T
F
K
T
T
L
-----
N
------
Q
P
-----
Y
H
L
M
F
K
V
G
D
D
L
R
Q
D
Q
L
V
V
Q
I
I
S
L
M
N
E
L
L
K
N
E
N
----
V
D
L
K
L
T
P
Y
K
I
L
A
T
G
P
Q
E
G
A
I
E
F
I
P
N
-
D
T
L
A
S
I
L
--------
S
K
Y
H
G
I
L
--------
G
Y
L
----------------------------------------
K
L
H
Y
P
--
D
E
NATL
G
V
Q
G
W
V
L
D
N
F
V
K
S
C
A
G
Y
C
V
I
T
Y
I
L
G
V
G
D
R
H
L
D
N
L
L
V
-
T
P
D
G
H
F
F
H
A
D
F
G
Y
I
L
G
Q
D
P
-----
K
P
F
P
P
L
M
K
L
P
P
Q
I
I
E
A
F
G
G
A
E
S
SN
Y
-------
D
-----
K
----
F
R
S
Y
C
F
V
A
Y
S
I
L
R
R
N
A
G
L
I
L
N
L
F
E
L
M
K
T
S
---
N
I
P
D
I
R
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
30.59
21%
-42
- C1 -
-
4JPS
1
PK3CA_HUMAN
A:
[753-1016]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
L
N
P
A
H
Q
L
G
N
L
R
L
E
E
-
C
R
I
M
S
S
A
K
R
P
L
W
L
N
W
E
N
P
D
-----
I
MSELLF
Q
N
-----
N
E
I
I
F
K
N
G
D
D
L
R
Q
D
M
L
T
L
Q
I
I
R
I
M
E
N
I
W
Q
N
Q
G
----
L
D
L
R
M
L
P
Y
G
C
L
S
I
G
D
C
V
G
L
I
E
V
V
R
N
S
H
T
I
M
Q
I
Q
--------
C
K
----------------------------------------------
F
N
S
H
T
L
H
Q
W
L
K
D
K
N
K
--
G
-----
E
I
Y
D
A
A
I
D
L
F
T
R
S
C
A
G
Y
C
V
A
T
F
I
L
G
I
G
D
R
H
N
S
N
I
M
V
-
K
D
D
G
Q
L
F
H
I
D
F
G
H
F
L
D
H
K
K
K
K
F
G
Y
K
R
E
R
V
P
F
V
L
T
Q
D
F
L
I
V
I
S
K
G
A
Q
--
E
CTKT
R
E
F
E
-----
R
----
F
Q
E
M
C
Y
K
A
Y
L
A
I
R
Q
H
A
N
L
F
I
N
L
F
S
M
M
L
G
S
---
G
M
P
E
L
Q
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
Fugue
30.41
12%
-7
- C1 -
-
1E8X
1
PK3CG_PIG
A:
[1-951]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
S
E
E
T
L
A
F
Q
R
Q
L
N
A
L
I
G
YDVTDVSN
V
H
D
D
E
L
E
F
T
R
R
R
L
V
T
P
R
M
A
E
V
A
G
R
D
P
K
L
Y
A
M
H
P
W
V
T
S
K
P
L
P
E
Y
L
L
K
K
I
T
N
N
C
V
F
I
V
I
H
R
S
T
T
S
Q
T
I
K
V
--
S
A
D
D
T
P
G
T
I
L
Q
S
F
F
T
K
M
A
N
E
R
D
F
V
L
R
V
C
G
R
D
E
Y
L
V
G
E
-
T
P
I
K
N
F
Q
W
V
R
Q
C
L
K
N
G
E
E
I
H
-----
L
V
--
L
D
T
P
P
D
P
A
L
D
E
---
V
R
K
E
C
D
R
K
F
R
V
K
I
R
G
I
D
I
PVLP
R
T
A
D
L
T
V
F
V
E
A
N
I
Q
Y
G
Q
Q
V
L
C
-----
Q
R
R
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--------------
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