@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_35_0480: (2018-03-12 )
MQLVSRTMSWNTTSFFTGSLDLEDEVKVLGDYVVGHRLGEGAYGSVYVVKYLPSGDRFALKILQKQDLFTSSGIYPVAYYDADGGASPWEADGVESHPLGGAPVPTVAALAKTFEQQIISEAMVMQALEHPHVVKFYKFLNSTTAFYFVMELAEGGKLLDLILSKSYFAEDEARMYFQQLLSAIDYCHRNGVAHKDLKAENLLLSDDGRLLVCDFGFSSKIAKENIDDPEQTIGTGGNAALLDAINNGGMFGTLHYTSPEAVMASSQQWKLAFAGDMAVPAETLGVPEDQHQGDPARYSPSSTATPWSSFSTSSSAASNASSCSGSLARGWRRRAAEVVSSKHCKARGKISGKGSGASLRTSNSTSLTDEAGAAHKPSVEKRRARPDSLTPLPSAAEAAAPGSSLQRAGSTHSLASATNGHRHKWVSPTSGLNKVGEGLSILVKSLMGSSGSSSGGHHHHHHRHDSHARSGHAKSPQGKQAAIIVPSSADAKAKLKRSSSTAALSVDGEAEEGNSRLHQPLRHLRTNAPSQARVPSPLSGASPSVSPTTSSFASPRFHESVAAAAACIADSPSATGAEKPSTLSSPAGSPTDSKSAITSPARHRPGTKDDIAVSDTNVGELGPPVTAFDRDAVGAPPLPLPVPPTTASTLKTPNSSSASPQALHHCHQAHEHKHHHRHRQRRSNSSSQIFGASTPCKSQPIIVDPFQQDLWSAGVILFFMLTGRLPFEGRDEEETLHLIQVNEFAFNDEEAQRISPAARRLVAQMLAPEPTDRPTIEQIIANPWFRRDLQLEKDFPHRKDLMEALGSASPDSALRHPLPQKSAKGAGPAADACAGPSGADRGGDTRAWMSTSHGVPSSCGSNATNAVAVSPRFHSFTPDVRAPVPLVPSHNTSFNVGPSAHPGGAPGSSPGSDQHRDASAHTTCNFLDFSTHHSITPEEEWVLETAFRKVDSDGYGCITRDQVRDMLTTLHGDVVPTKDVDELVCLFTGDASAASITFQQFRDAWVSKDLAHTPFTHNSEFQLVNIIGTEMDAVERGVVRQLRTAFNSLDENHRGVIQLHQVQRVFEKCQIAVHKEECLSFIKYFHESELACCHNRASLYSQRRGPAPNTMSLLHASGAASPRGFAKVHSLPSATGATQGGSPATTHYSATTPKQPSETGDSDTATITAAAGGTTYTGSQATSRGAPKSPLSPSSITVSFNSFVRGIVKSDILLKHPLGRKLAAATNLAALFQSRNVTECVRHGFLVTGLQSVILTKLASMPERLQLLYSDKVVSNAANVYSFRYLGSSSLATMPTTSTATPPMSSPLVAMAASTDPAATCSPIGLQGSFSAQHRNHATPAVSSLQRRTVSSDAGNGATGSTAATSNAGTHPHNPSPCLSDRSTVRSHATCTKPSSASPHSLARADSPGSAMHSPSPEISGSTLTSCGAFVSQSQRSPAVPMHRSSSRPRATGGTSAHRMASRSASARGAAPSHPVALCCPSNSLQHTPTSLCARRRHLRGQDAHTDPRHDTVRDGDGVRDNTRGFSSCPHNSSSAVNTAIDDSHSKRSRSALSPGMGEELKGPNTTPAAGGQRRVKENVTQLPFPSISSAVAILSTTSATLAHPGVAYSSSDAVTLVNGVCDLDVILSPASLGYTMVQFRCIHGKTSDFHEAVAFISNVLEVEREQAMQDTMTRGESELM
Atome Classification :
(20 SA)
.........10........20.....----------...30........40........50........60........70........80........90........100.......110.......120......-.130.......140.......150.......160.....-..170.......180.......190.......200...---.---.---..210.......220.......--230.......240.......250.......260.-----......270.......280.......290.......300.......310.-......320.......330.......340.......350.......360.......370.......380..--.....390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310......1320......1330......1340......1350......1360......1370......1380......1390......1400......1410......1420......1430......1440......1450......1460......1470......1480......1490......1500......1510......1520......1530......1540......1550......1560......1570......1580......1590......1600......1610......1620......1630......1640......1650......1660......1670......1680
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
Q
L
V
S
R
TMSWNT
T
S
F
F
TGSLD
L
E
D
E
V
----------
K
V
L
G
D
Y
V
V
G
HRLGEGAYG
S
V
Y
V
V
K
YLPSG
D
R
F
A
L
K
I
L
Q
K
QDLFTSSG
I
Y
P
V
A
Y
Y
DADGGASPWEADGVESHPLGGAP
V
P
T
V
A
A
L
A
K
T
F
E
Q
Q
I
I
S
E
A
M
V
M
Q
A
L-EH
P
H
V
V
K
F
Y
K
F
L
NSTT
A
F
Y
F
V
M
E
L
AEGG
K
L
L
D
L
I
LSKSY-F
A
E
D
E
A
R
M
Y
F
Q
Q
L
L
S
A
I
D
Y
C
H
RNGVAHKDLKAE
N
L
L
LS---D---D---G
R
L
L
V
C
DFGFSS
K
I
A
KENID
D
P
--
E
Q
T
IGTGG
N
A
A
L
L
D
AINNG
G
M
F
G
T
L
H
YT
S
P
E
A
V
M-----ASSQ
Q
W
K
L
A
F
AGDMAV
P
A
E
TLGVPEDQHQGDPARYSPSSTATPWSSFSTS-SSAASNASSCS
G
S
L
A
R
G
W
R
R
R
A
A
E
V
V
S
S
KHCKARGKISGKGSG
A
S
L
RTSNSTSLTDEAGAAHKP
S
V
E
K
RRA--RPDSLTPLPSAAEAAAPG
S
S
L
Q
RAGSTHSLASATNGH
R
H
KWVSPTS
G
L
N
K
V
G
E
G
L
S
I
L
V
K
S
L
MGSSGSSSGGHHHHHHRHDSHARSGHAKSPQG
K
Q
A
A
I
I
VPSSAD
A
K
A
K
L
KRSSS
T
A
A
L
S
VDGEAEEG
N
S
R
L
H
Q
P
L
R
H
L
RTNAPSQARVPSPLSGASPSVSPTTSSFASP
R
F
H
E
S
V
A
A
A
A
A
CIADSPSATGAEKPSTLSSPAGSPTDSKSAITSPARHRPGTKD
D
I
A
VSDTNVGELGPPVTAFDRDAVGAPPLPLPVPPTTASTLKTPNSSSA
S
P
Q
A
L
H
H
C
H
Q
A
H
E
H
K
H
H
H
R
H
R
Q
RRSNSSS
Q
I
FGASTPCKSQ
P
I
I
VD
P
F
Q
Q
D
L
W
S
A
G
V
I
L
F
F
M
L
TGRLPFEGRDEE
E
T
L
H
L
I
Q
V
NEFAF
N
D
E
E
A
Q
R
I
S
P
A
A
R
R
L
V
A
Q
M
LAPEPTD
R
P
T
I
E
Q
I
I
ANP
W
F
RRDLQLEKDFP
H
R
K
D
L
M
E
A
LGSASP
D
S
A
LRHPLPQKSAKGAGPAADACAGPSGADRGGDT
R
A
W
M
STSHGVPSSCGSNAT
N
A
V
A
VSPRFHSFTPDVRAPVPLVPSHNTSFNVGPSAHPGGAPGSSPGSDQHRDASAH
T
T
C
N
F
L
DFSTHHSIT
P
E
E
E
W
V
L
E
T
A
F
R
KVDSDGYGCI
T
R
D
Q
V
R
D
M
L
T
T
L
HGDVVPTK
D
V
D
E
L
V
C
L
FTGDAS
A
A
S
I
T
F
Q
Q
F
R
D
A
W
VSKDLAHTPFTHNSE
F
Q
L
V
N
I
IG
T
E
M
D
A
V
E
R
G
V
V
R
Q
L
R
T
A
F
N
SLDENH
R
G
V
I
Q
L
H
Q
V
Q
R
V
F
E
K
C
Q
I
AV
H
K
E
E
C
L
S
F
I
K
Y
F
H
E
S
E
L
A
C
C
H
N
R
A
S
L
Y
S
QRRGPAPNT
M
S
L
L
HASGAASPR
G
F
A
K
V
HSLPSATGATQGGSPAT
T
H
YSATTPKQPSETGDSD
T
A
T
I
T
AAAGG
T
T
YTGSQATSRGAPKSPLSPS
S
I
T
V
S
F
N
S
F
V
R
G
I
V
KSD
I
L
LKHPLG
R
K
L
A
A
A
T
N
L
A
A
L
F
QSR
N
V
T
E
C
V
RH
G
F
L
V
T
G
L
Q
S
V
I
L
T
K
L
AS
M
P
E
R
L
Q
L
L
YSDKVVSNAA
N
V
Y
S
F
R
Y
LGSSSLATMPTTSTATPPMSSP
L
V
A
M
AASTDPAATCSPIGLQGSFSAQHRNHA
T
P
A
V
S
S
L
Q
R
R
TVSSDAGNGATGSTAATSNAGTHPHNPSPCLS
D
R
S
T
V
RSHATCTKPSSASPHSLARADSPGSAMHSPSPEISGS
T
L
T
S
C
G
A
F
V
S
QSQRSPAVPMHRSSSRPRATGG
T
S
A
H
R
M
A
SRSASARGAAPSH
P
V
A
L
C
CPSNSLQHT
P
T
S
L
C
A
R
R
R
HLRGQDAHTDPRHDTVRDGDGVRDNTRGFSSCPHNSSSAVNTAIDDSHSKRSRSALSPGMGEELKGPNTTPAAGG
Q
R
R
V
K
E
N
V
TQLPFP
S
I
S
S
A
V
A
I
L
STTSATLAHPGVAYSSSD
A
V
T
L
VNGVCD
L
D
V
I
LSPASL
G
Y
T
M
V
Q
F
R
C
IHGKT
S
D
F
H
E
A
V
A
F
I
S
N
V
L
E
V
E
R
E
Q
A
M
Q
D
T
M
TRGESELM
45
Fugue
84.93
23%
-
- C1 -
-
3H4J
-
SNF1_SCHPO
B:
[27-356]
------------------------
S
K
----------
R
H
I
G
P
Y
I
I
R
E
T
L
G
E
G
S
F
G
K
V
K
L
A
T
H
Y
K
T
Q
Q
K
V
A
L
K
F
I
S
R
Q
L
L
K
K
S
D
-----------------------------------------
M
H
M
R
V
E
R
E
I
S
Y
L
K
L
L
-
R
H
P
H
I
I
K
L
Y
D
V
I
T
T
P
T
D
I
V
M
V
I
E
Y
A
-
G
G
E
L
F
D
Y
I
V
E
K
K
R
-
M
T
E
D
E
G
R
R
F
F
Q
Q
I
I
C
A
I
E
Y
C
H
R
H
K
I
V
H
R
D
L
K
P
E
N
L
L
L
D
---
D
---
N
---
L
N
V
K
I
A
D
F
G
L
S
N
I
M
T
D
G
N
F
L
K
T
--
S
C
--------------------
G
S
P
N
Y
A
A
P
E
V
I
N
-----
G
K
L
Y
A
G
P
E
V
D
V
W
S
C
G
I
V
L
Y
V
M
L
V
G
R
L
P
F
D
D
E
F
I
P
N
L
F
K
K
V
N
S
C
V
Y
V
M
P
D
F
L
S
P
G
A
Q
S
L
I
R
R
M
I
V
A
D
P
M
Q
R
I
T
I
Q
E
I
R
R
D
P
W
F
N
V
N
L
P
D
Y
L
R
P
M
E
E
V
Q
G
S
Y
A
D
S
R
I
V
S
K
L
G
E
A
M
G
F
S
E
D
Y
I
V
E
AL
R
S
D
E
N
N
E
V
K
E
A
Y
N
L
L
H
E
N
Q
V
I
Q
E
K
L
E
H
H
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
62.67
31%
-144
- C1 -
-
4D28
-
CIPKO_ARATH
A:
[8-172]
--------------------------------------
V
G
K
Y
E
V
G
R
T
I
-----
A
K
V
K
F
A
R
N
T
D
T
G
D
N
V
A
I
K
I
M
A
K
S
T
I
L
K
N
R
M
V
-----------------------------------------
D
Q
I
K
R
E
I
S
I
M
K
I
V
-
R
H
P
N
I
V
R
L
Y
E
V
L
A
S
K
S
K
I
Y
I
V
L
E
F
V
T
G
G
E
L
F
D
R
I
V
H
K
G
R
-
L
K
E
D
E
S
R
K
Y
F
Q
Q
L
V
D
A
V
A
H
C
H
S
K
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
D
---
T
---
N
---
G
N
L
K
V
S
D
F
G
L
S
A
-
L
P
Q
E
G
---
L
--
N
D
T
C
G
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
61.36
33%
-106
- C1 -
-
4CZU
3
CIPKN_ARATH
A:
[10-197]
--------------------------------------
V
G
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
L
K
N
K
M
I
-----------------------------------------
A
Q
I
K
R
E
I
S
T
M
K
L
I
-
K
H
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
R
-
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
D
---
A
---
N
---
G
A
L
K
V
S
D
F
G
L
S
A
-
L
P
Q
Q
V
R
E
D
G
LL
H
D
T
C
G
T
-
P
N
Y
V
A
P
E
V
I
N
N
K
G
Y
D
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
61.14
31%
-152
- C1 -
-
4ZHX
2
AAPK2_HUMAN
A:
[26-311]
--------------------------------------
I
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
R
S
---------
L
D
V
V
G
--------------------------------
K
I
K
R
E
I
Q
N
L
K
L
F
-
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
G
R
-
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
---
A
---
H
---
M
N
A
K
I
A
D
F
G
L
S
N
M
M
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
61.06
31%
-144
- C1 -
-
5ISO
2
?
A:
[13-255]
--------------------------------------
I
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
R
S
---------
L
D
V
V
G
--------------------------------
K
I
K
R
E
I
Q
N
L
K
L
F
-
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
G
R
-
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
---
A
---
H
---
M
N
A
K
I
A
D
F
G
L
S
N
M
M
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
60.66
31%
-150
- C1 -
-
5EZV
2
AAPK1_HUMAN (first)
A:
[27-275]
--------------------------------------
I
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
R
S
---------
L
D
V
V
G
--------------------------------
K
I
K
R
E
I
Q
N
L
K
L
F
-
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
G
R
-
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
---
A
---
H
---
M
N
A
K
I
A
D
F
G
L
S
N
M
M
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
60.05
35%
-130
- C1 -
-
4YSM
-
?
B:
[27-183]
------------------------------------
A
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
V
T
G
Q
E
Y
A
V
K
V
I
S
K
R
Q
V
K
Q
-----------------------------------------
K
T
D
K
E
L
L
L
K
E
V
E
L
L
K
K
L
-
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
T
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
NKR
K
---
D
---
A
N
I
R
I
I
D
F
G
L
S
T
H
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
59.99
28%
-142
- C- -
-
3FE3
-
MARK3_HUMAN
A:
[50-202]
-------------------------
Q
----------
P
H
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
R
E
V
A
I
K
I
I
D
K
T
Q
L
N
P
T
S
------------------------------------------
L
Q
K
L
F
R
E
V
R
I
M
K
I
L
-
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
I
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
R
-
M
K
E
K
E
A
R
S
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
R
I
V
H
R
D
L
K
A
E
N
L
L
L
D
---
A
---
D
---
M
N
I
K
I
A
D
F
G
F
S
N
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
59.45
28%
-146
- C1 -
-
3IEC
-
MARK2_HUMAN
A:
[6-160]
--------------------------------------
I
G
N
Y
R
L
L
K
T
I
G
----
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
I
D
K
T
Q
L
N
S
S
S
------------------------------------------
L
Q
K
L
F
R
E
V
R
I
M
K
V
L
-
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
W
-
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
L
D
---
A
---
D
---
M
N
I
K
I
A
D
F
G
F
S
N
E
F
T
F
G
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
59.09
31%
-145
- C1 -
-
4CFE
2
AAPK2_HUMAN
A:
[32-302]
--------------------------------------
I
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
R
S
---------
L
D
V
V
G
--------------------------------
K
I
K
R
E
I
Q
N
L
K
L
F
-
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
G
R
-
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
---
A
---
H
---
M
N
A
K
I
A
D
F
G
L
S
N
M
M
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
58.73
31%
-145
- C1 -
-
4CFF
2
AAPK2_HUMAN
A:
[32-303]
--------------------------------------
I
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
R
S
---------
L
D
V
V
G
--------------------------------
K
I
K
R
E
I
Q
N
L
K
L
F
-
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
G
R
-
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
---
A
---
H
---
M
N
A
K
I
A
D
F
G
L
S
N
M
M
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
57.33
30%
-155
- C1 -
-
4RED
-
AAPK1_HUMAN
A:
[15-180]
--------------------------------------
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
A
V
A
V
K
I
L
N
R
Q
K
I
R
S
---------
L
D
V
V
G
--------------------------------
K
I
R
R
E
I
Q
N
L
K
L
F
-
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
-
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
---
A
---
H
---
M
N
A
K
I
A
D
F
G
L
S
N
M
M
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
57.23
30%
-137
- C1 -
-
4RER
2
AAPK1_HUMAN
A:
[5-238]
--------------------------------------
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
R
S
---------
L
D
V
V
G
--------------------------------
K
I
R
R
E
I
Q
N
L
K
L
F
-
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
-
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
---
A
---
H
---
M
N
A
K
I
A
D
F
G
L
S
N
M
M
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
57.18
33%
-88
- C1 -
-
4CZT
2
CIPKN_ARATH
A:
[10-194]
--------------------------------------
V
G
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
L
K
N
K
M
I
-----------------------------------------
A
Q
I
K
R
E
I
S
T
M
K
L
I
-
K
H
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
R
-
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
D
---
A
---
N
---
G
A
L
K
V
S
D
F
G
L
S
A
L
P
Q
Q
V
R
E
D
G
L
--
L
H
T
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
G
Y
D
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
57.17
35%
-109
- C1 -
-
3NYV
1
?
A:
[24-188]
-------------------------------------
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
Q
V
K
Q
-----------------------------------------
K
T
D
K
E
S
L
L
R
E
V
Q
L
L
K
Q
L
-
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
SKS
K
---
D
---
A
N
I
R
I
I
D
F
G
L
S
T
H
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
56.56
32%
-133
- C1 -
-
2WEL
6
KCC2D_HUMAN
A:
[3-160]
--------------------------------------
T
D
E
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
K
L
S
------------------------------------------
A
R
D
H
Q
K
L
E
R
E
A
R
I
C
R
L
L
-
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
---
S
---
K
SKG
A
A
V
K
L
A
D
F
G
L
A
I
E
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
Fugue
56.51
17%
32
- C1 -
-
1KOB
1
?
A:
[23-374]
-----------
I
N
D
Y
D
K
F
Y
E
D
I
W
K
K
Y
V
P
Q
P
V
E
V
K
QG
S
V
Y
D
Y
Y
D
I
L
E
E
L
G
S
G
A
F
G
V
V
H
R
C
V
E
K
A
T
G
R
V
F
V
A
K
F
I
N
T
P
Y
--------------------------------------------
P
L
D
K
Y
T
V
K
N
E
I
S
I
M
N
Q
L
-
H
H
P
K
L
I
N
L
H
D
A
F
E
D
K
Y
E
M
V
L
I
L
E
F
L
S
G
G
E
L
F
D
R
I
A
A
E
D
Y
K
M
S
E
A
E
V
I
N
Y
M
R
Q
A
C
E
G
L
K
H
M
H
E
H
S
I
V
H
L
D
I
K
P
E
N
I
M
C
E
---
T
KK-
A
---
S
S
V
K
I
I
D
F
G
L
A
T
K
L
N
P
D
E
----------------------
I
V
K
V
T
T
A
T
A
E
F
A
A
P
E
I
V
D
REPVG
F
Y
T
D
M
W
A
I
G
V
L
G
Y
V
L
L
S
G
L
S
P
-
F
A
G
E
D
D
L
E
T
L
Q
N
V
K
R
C
D
W
E
F
D
E
D
A
F
S
S
V
-
S
P
E
A
K
D
F
I
K
N
L
L
Q
K
E
P
R
K
R
L
T
V
H
D
A
L
E
H
P
W
L
K
G
D
H
S
N
L
T
S
R
I
P
S
S
R
Y
N
K
I
R
Q
K
I
K
E
K
Y
A
D
W
P
A
P
Q
P
A
I
G
R
I
--
A
N
F
S
S
L
R
K
H
R
P
Q
E
Y
Q
I
Y
D
S
Y
F
D
R
K
E
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
55.65
30%
-141
- C1 -
-
4CFH
1
AAPK1_RAT
A:
[32-243]
--------------------------------------
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
R
S
---------
L
D
V
V
G
--------------------------------
K
I
R
R
E
I
Q
N
L
K
L
F
-
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
-
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
---
A
---
H
---
M
N
A
K
I
A
D
F
G
L
S
N
M
M
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
55.16
31%
-121
- C1 -
-
4Y5Q
1
?
A:
[19-197]
------------------------------------
T
F
A
E
R
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
A
S
A
K
N
------------------------------------------
K
D
T
S
T
I
L
R
E
V
E
L
L
K
K
L
-
D
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
R
-
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
---
S
KEK
D
---
C
D
I
K
I
I
D
F
G
L
S
T
C
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
54.89
27%
-76
- C1 -
-
2Y7J
1
PHKG2_HUMAN
D:
[90-271]
-------------------------
K
----------
E
F
Y
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
E
V
---
R
L
S
------------------------------------
P
E
Q
L
E
E
V
R
E
A
T
R
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
V
A
-
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
D
---
D
---
N
---
M
Q
I
R
L
S
D
F
G
F
S
C
H
L
E
P
G
E
----------------------
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------