@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_35_1070: (2018-03-13 )
MTVLPPKINVPATPALDGVDINSLYDVNHGKLLGKGGFSEVLAVRHIPSGEIRALKVMMRSSLVGKKAEMVAHEKEILRRTCHPAIITLHEAVQTPDKVYFALDLMNEDLFEFIVRNKTVNEDLSRAIMHQLMSGIAYLHEQSIVHRDIKPENILINVVVKSEANNAANDDSESATRVEGLQVMSDINSIPLEKLNVEVKIADFGLAKVVMEWDVCSTPCGTSFYIAPEVIRGIEEQGAKPLCTNQRLVKSVDVWSAGVVFYVLLCGRPPFHGQVRTGQDRRDLLRRIDHGVLFNPNHGWDSISAEAKNLILKMLDQESSKRITSDEVLRHPFFTAHGYSRPVPASDARRRFMQMQQLSLRTKVPAAQSAEAQVKTMSPLSGPDGQQIKVSSSGGGSSSKGSSNSTGSFLSSIKDFFGHRSKHTSDISKEERQRMHAELAELQATVIAEEDQEGDVTSYKPSMPVKEAKPARTAVMNMKAKVGPDALRK
Atome Classification :
(22 SA)
-----------------------------------------------------------------------------------------------------------------------------------------.........10........20.--.......30........40........50........60...------.----..-..70........80-........90........100....-.-.-.110....--..----.120.......130.......140.......150.......160.......170.......180.......190.......200.....-..210..-.....220.......230.......240.......250.......260.......270.......280.......290.-......300.......310.......320.-----......330.......340.......350.--......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-----------------------------------------------------------------------------------------------------------------------------------------MTVLPPKINVPATPALDGVDIN--
S
L
Y
DVNH
G
K
L
LGKGG
F
S
E
V
L
A
VRHIPSG
E
I
R
A
L
K
V
M
M
R
S
S
LV------G----
K
K
-
A
E
M
V
A
H
E
K
E
I
L
R
R
T-CH
P
A
I
I
T
L
H
E
A
VQTP
D
K
V
Y
F
A
L
D
L
M-
N
-
E
-
D
L
F
E
F
I
VR--NK----TV
N
E
D
L
S
R
A
I
M
H
Q
L
M
S
G
I
A
Y
L
H
E
Q
S
I
V
HRDIKPE
N
I
L
I
N
V
V
V
KSEANNAANDDSES
A
T
R
V
E
G
L
Q
V
M
S
D
I
N
SIP
L
E
K
L
N
V
E
V
K
I
ADF
G
L
A
-
K
V
V
MEWD-VCSTPCGT
S
F
Y
I
A
P
E
V
I
R
G
I
E
E
QGAKPLCT
N
Q
R
L
V
K
S
V
D
V
W
S
A
G
V
V
F
Y
V
LLCGRPPFHGQVRT
G
Q
D
R
R
D
L
L
R
RIDH
G
V
L
-FNPNHGWDS
I
S
A
E
A
K
N
L
I
L
K
M
L
D
Q
E
SSKRI-----
T
S
D
E
V
L
RHPFFTAHGYSRPVP
A
S
D
A
R
R
R
F
M
--
Q
M
Q
Q
L
S
L
RTKVPAAQSAE
A
Q
V
K
TMSPLSGPDG
Q
Q
I
K
V
SSSGGGSSSKGSSNS
T
G
S
F
L
S
S
I
K
D
F
FGHRSKHTSDI
S
K
E
E
R
Q
R
M
H
A
E
L
A
E
L
Q
A
T
V
I
AEEDQEGDVTSYKPSMPVKEAKPAR
T
A
V
M
NMKAKV
G
P
D
A
LRK
27
HHSearch
74.10
36%
-71
- C1 -
-
2BDW
-
KCC2D_CAEEL
A:
[8-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------
K
F
S
--
D
N
Y
D
V
--
K
E
E
L
G
K
G
A
F
S
V
V
R
R
C
V
H
K
T
T
G
L
E
F
A
A
K
I
I
N
T
K
K
L
S
------
A
----
R
D
-
F
Q
K
L
E
R
E
A
R
I
C
R
K
L
-
Q
H
P
N
I
V
R
L
H
D
S
I
Q
E
E
S
F
H
Y
L
V
F
D
L
V
-
T
G
G
-
E
L
F
E
D
I
V
A
--
R
E
----
F
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
I
A
Y
C
H
S
N
G
I
V
H
R
N
L
K
P
E
N
L
L
L
A
S
K
A
----------------------------------
K
G
A
A
V
K
L
A
D
F
G
L
A
-
I
E
V
N
D
S
E
-
A
W
H
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
K
K
------------
D
P
Y
S
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
-----
H
R
L
Y
A
Q
I
K
A
G
A
Y
-
D
Y
P
S
P
E
W
D
T
V
T
P
E
A
K
S
L
I
D
S
M
L
T
V
N
P
K
K
R
I
-----
T
A
D
Q
A
L
K
V
P
W
I
C
N
R
----------------------------------------------------------------------------------------------------------------------------------------------------------
53
Fugue
73.72
25%
45
- C1 -
-
2ACX
1
GRK6_HUMAN
A:
[14-532]
KARKGKSKK
W
R
Q
M
L
QFPHISQC
E
E
L
R
L
S
LERD
Y
H
S
L
C
ERN
P
I
G
R
L
L
F
R
E
F
C
A
T
R
P
E
L
S
R
C
V
A
F
L
D
G
V
A
E
Y
E
V
TPDDK
R
K
A
C
G
R
N
L
T
Q
N
FLSHTGPDLIPEVP
R
Q
L
V
T
N
C
T
Q
R
L
E
Q
GPCKDLF
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
PV
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
R
A
T
G
K
M
Y
A
C
K
K
L
E
K
K
R
I
K
------
K
----
R
K
G
E
A
M
A
L
N
E
K
Q
I
L
E
K
V
-
N
S
R
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
-
N
G
G
-
D
L
K
F
H
I
Y
H
MG
Q
A
----
G
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
E
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
--------------------
H
G
-----------------
H
I
R
I
S
D
L
G
L
A
-
V
H
V
P
E
G
Q
-
T
I
K
G
R
V
G
T
V
G
Y
M
A
P
E
V
V
K
N
------------
E
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
F
Q
Q
R
-
K
K
K
I
K
R
E
E
V
E
R
L
V
K
E
V
P
E
-
E
Y
S
----
E
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
GCRGG
S
A
R
E
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
--------------------------------
G
M
L
E
P
P
F
K
P
D
P
----------------------------------
Q
A
I
Y
C
E
P
T
D
Q
D
F
Y
Q
K
F
A
T
G
S
V
P
I
P
W
Q
N
E
M
V
E
----------------------
T
E
C
F
Q
E
L
N
V
F
G
L
D
G
S
--
10
PsiBlast_PDB
67.62
33%
-65
- C1 -
-
5JZJ
2
DCLK1_HUMAN
A:
[28-294]
------------------------------------------------------------------------------------------------------------------------------------------------
F
Q
I
P
A
T
-------
I
T
--
E
R
Y
K
V
--
G
R
T
I
G
D
G
N
F
A
V
V
K
E
C
V
E
R
S
T
A
R
E
Y
A
L
K
I
I
K
K
S
K
C
R
------
G
----
K
E
--
H
M
I
Q
N
E
V
S
I
L
R
R
V
-
K
H
P
N
I
V
L
L
I
E
E
M
D
V
P
T
E
L
Y
L
V
M
E
L
V
K
G
-
G
-
D
L
F
D
A
I
T
S
--
T
N
----
K
Y
T
E
R
D
A
S
G
M
L
Y
N
L
A
S
A
I
K
Y
L
H
S
L
N
I
V
H
R
D
I
K
P
E
N
L
L
V
Y
---------
E
H
Q
D
G
S
K
S
------------------------
L
K
L
G
D
F
G
L
A
-
T
I
V
D
--
G
-
P
L
Y
T
V
C
G
T
P
T
Y
V
A
P
E
I
I
A
---
E
T
G
Y
G
---------
L
K
V
D
I
W
A
A
G
V
I
T
Y
I
L
L
C
G
F
P
P
F
R
G
---
S
----
E
V
L
F
D
Q
I
L
M
G
Q
V
-
D
F
P
S
P
Y
W
D
N
V
S
D
S
A
K
E
L
I
T
M
M
L
L
V
D
V
D
Q
R
F
-----
S
A
V
Q
V
L
E
H
P
W
--------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
67.56
29%
-21
- C1 -
-
5U6Y
-
KCC2A_RAT
A:
[8-331]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
K
G
A
F
S
V
V
R
R
C
V
K
V
L
A
G
Q
E
Y
A
A
K
I
I
N
T
K
K
L
S
------
A
----
R
D
-
H
Q
K
L
E
R
E
A
R
I
C
R
L
L
-
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
H
H
Y
L
I
F
D
L
V
-
T
-
G
G
E
L
F
E
D
I
V
A
--
R
E
----
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
D
L
K
P
E
N
L
L
L
------------------
A
S
K
L
K
G
----------------
A
A
V
K
L
A
D
F
G
L
A
I
E
V
E
G
E
Q
Q
-
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
--
K
D
P
Y
G
K
P
----------
V
D
L
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
-----
W
D
E
D
Q
H
R
L
Y
Q
Q
I
K
A
G
A
Y
-
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
S
K
R
I
-----
T
A
A
E
A
L
K
H
P
W
I
S
----
H
R
S
T
V
A
S
C
M
H
R
Q
E
T
V
D
C
L
K
K
F
N
A
R
R
K
L
K
G
-----
A
I
L
T
T
M
L
A
T
R
N
F
S
G
-----
G
K
S
G
G
N
K
K
S
D
G
V
K
E
S
S
E
S
T
N
T
T
I
E
D
--------------------------------------------------------------------------
28
HHSearch
67.23
35%
-69
- C1 -
-
5IG1
-
?
A:
[18-281]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
D
K
--
R
S
V
I
G
K
G
A
F
S
T
V
H
R
C
V
N
K
R
T
G
E
V
C
A
V
K
V
I
A
L
K
S
L
R
------
S
----
S
E
-
I
N
K
I
K
R
E
I
G
I
C
S
S
L
-
Q
H
E
H
I
V
S
M
R
R
A
F
R
D
E
S
H
F
Y
L
V
F
E
Y
V
-
S
G
G
-
E
L
F
D
E
I
V
T
--
R
K
----
F
Y
N
E
K
D
A
S
A
C
M
H
Q
I
L
S
A
L
Q
H
C
H
S
K
N
I
I
H
R
D
L
K
P
E
N
L
L
L
A
S
K
D
----------------------------------
P
N
A
P
V
K
I
T
D
F
G
L
A
-
V
I
M
E
Q
G
P
-
T
Y
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
I
R
R
------------
V
P
Y
D
T
A
V
D
V
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
E
E
D
H
-----
Q
K
L
Y
A
Q
I
K
N
C
Q
Y
-
D
F
P
S
P
E
W
D
S
V
T
T
A
A
K
E
L
I
K
A
M
L
E
P
N
P
K
R
R
P
-----
T
V
Q
E
L
L
Q
H
P
W
I
A
R
R
D
V
--------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
67.13
32%
-127
- C1 -
-
3DFA
-
?
A:
[12-266]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
A
S
A
K
------
N
----
K
D
-
T
S
T
I
L
R
E
V
E
L
L
K
K
L
-
D
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
-
T
-
G
-
E
L
F
D
E
I
I
K
--
R
K
----
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
--------------------
K
------------------
D
C
D
I
K
I
I
D
F
G
L
S
-
T
C
F
Q
Q
N
T
-
K
M
K
D
R
I
G
T
A
Y
Y
I
A
P
E
V
L
R
G
T
Y
D
E
-------------
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
-----
G
K
N
E
Y
D
I
L
K
R
V
E
T
G
K
Y
-
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
-----
T
A
T
Q
C
L
E
H
P
W
I
Q
K
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
67.10
32%
-68
- C1 -
-
3KK8
-
KCC2D_CAEEL
A:
[8-266]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
V
K
E
E
--
L
G
K
G
A
F
S
V
V
R
R
C
V
H
K
T
T
G
L
E
F
A
A
K
I
I
N
T
K
K
L
S
------
A
----
R
D
-
F
Q
K
L
E
R
E
A
R
I
C
R
K
L
-
Q
H
P
N
I
V
R
L
H
D
S
I
Q
E
E
S
F
H
Y
L
V
F
D
L
V
-
T
-
G
G
E
L
F
E
D
I
V
A
--
R
E
----
F
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
I
A
Y
C
H
S
N
G
I
V
H
R
N
L
K
P
E
N
L
L
L
----
A
S
K
A
K
G
A
A
------------------------------
V
K
L
A
D
F
G
L
A
-
I
E
V
N
D
S
E
-
A
W
H
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
K
--
K
D
P
Y
S
K
P
----------
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
-----
W
D
E
D
Q
H
R
L
Y
A
Q
I
K
A
G
A
Y
-
D
Y
P
S
P
E
W
D
T
V
T
P
E
A
K
S
L
I
D
S
M
L
T
V
N
P
K
K
R
I
-----
T
A
D
Q
A
L
K
V
P
W
I
C
------------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
66.61
31%
-55
- C1 -
-
3C0I
1
CSKP_HUMAN
A:
[22-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
--
D
V
Y
E
L
--
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
S
SP---
G
----
L
S
-
T
E
D
L
K
R
E
A
S
I
C
H
M
L
-
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
-
D
G
A
-
D
L
C
F
E
I
V
K
--
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
E
----------------------------------
N
S
A
P
V
K
L
G
G
F
G
V
A
-
I
Q
L
G
E
S
G
L
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
R
------------
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
K
E
------
R
L
F
E
G
I
I
K
G
K
Y
-
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
-----
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
---------------------------------------------------------------------------------------------------------------------------------------------------------
39
HHSearch
66.23
31%
-55
- C1 -
-
3C0G
1
CSKP_HUMAN
B:
[22-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
--
D
V
Y
E
L
--
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
S
SP---
G
----
L
S
-
T
E
D
L
K
R
E
A
S
I
C
H
M
L
-
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
-
D
G
A
-
D
L
C
F
E
I
V
K
--
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
E
----------------------------------
N
S
A
P
V
K
L
G
G
F
G
V
A
-
I
Q
L
G
E
S
G
L
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
R
------------
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
K
E
------
R
L
F
E
G
I
I
K
G
K
Y
-
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
-----
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
---------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
65.69
32%
-63
- C1 -
-
2BDW
-
KCC2D_CAEEL
A:
[13-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
V
K
--
E
E
L
G
K
G
A
F
S
V
V
R
R
C
V
H
K
T
T
G
L
E
F
A
A
K
I
I
N
T
K
K
L
S
------
A
----
R
D
-
F
Q
K
L
E
R
E
A
R
I
C
R
K
L
-
Q
H
P
N
I
V
R
L
H
D
S
I
Q
E
E
S
F
H
Y
L
V
F
D
L
V
-
T
-
G
G
E
L
F
E
D
I
V
A
--
R
E
----
F
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
I
A
Y
C
H
S
N
G
I
V
H
R
N
L
K
P
E
N
L
L
L
----
A
S
K
A
K
G
A
A
------------------------------
V
K
L
A
D
F
G
L
A
-
I
E
V
N
D
S
E
-
A
W
H
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
K
--
K
D
P
Y
S
K
P
----------
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
-----
W
D
E
D
Q
H
R
L
Y
A
Q
I
K
A
G
A
Y
-
D
Y
P
S
P
E
W
D
T
V
T
P
E
A
K
S
L
I
D
S
M
L
T
V
N
P
K
K
R
I
-----
T
A
D
Q
A
L
K
V
P
W
--------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
65.00
35%
-68
- C1 -
-
5IG1
-
?
B:
[18-281]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
D
K
--
R
S
V
I
G
K
G
A
F
S
T
V
H
R
C
V
N
K
R
T
G
E
V
C
A
V
K
V
I
A
L
K
S
L
R
------
S
----
S
E
-
I
N
K
I
K
R
E
I
G
I
C
S
S
L
-
Q
H
E
H
I
V
S
M
R
R
A
F
R
D
E
S
H
F
Y
L
V
F
E
Y
V
-
S
G
G
-
E
L
F
D
E
I
V
T
--
R
K
----
F
Y
N
E
K
D
A
S
A
C
M
H
Q
I
L
S
A
L
Q
H
C
H
S
K
N
I
I
H
R
D
L
K
P
E
N
L
L
L
A
S
K
D
----------------------------------
P
N
A
P
V
K
I
T
D
F
G
L
A
-
V
I
M
E
Q
G
P
-
T
Y
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
I
R
R
------------
V
P
Y
D
T
A
V
D
V
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
E
E
D
H
-----
Q
K
L
Y
A
Q
I
K
N
C
Q
Y
-
D
F
P
S
P
E
W
D
S
V
T
T
A
A
K
E
L
I
K
A
M
L
E
P
N
P
K
R
R
P
-----
T
V
Q
E
L
L
Q
H
P
W
I
A
R
R
D
V
--------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
63.52
32%
-63
- C1 -
-
3MWU
1
?
A:
[29-309]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
A
S
A
K
------
N
----
K
D
-
T
S
T
I
L
R
E
V
E
L
L
K
K
L
-
D
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
-
T
-
G
G
E
L
F
D
E
I
I
K
--
R
K
----
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
----------------
E
S
K
E
K
------------------
D
C
D
I
K
I
I
D
F
G
L
S
-
T
C
F
Q
Q
N
-----
D
R
I
G
T
A
Y
Y
I
A
P
E
V
L
R
G
T
Y
D
E
-------------
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
-----
G
K
N
E
Y
D
I
L
K
R
V
E
T
G
K
Y
-
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
-----
T
A
T
Q
C
L
E
H
P
W
I
Q
K
Y
S
S
E
T
P
T
----------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
62.87
33%
-54
- C1 -
-
5JZN
1
DCLK1_HUMAN
A:
[24-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
R
T
I
G
D
G
N
F
A
V
V
K
E
C
V
E
R
S
T
A
R
E
Y
A
L
K
I
I
K
K
S
K
C
R
------
G
----
K
E
--
H
M
I
Q
N
E
V
S
I
L
R
R
V
-
K
H
P
N
I
V
L
L
I
E
E
M
D
V
P
T
E
L
Y
L
V
M
E
L
V
K
G
-
G
-
D
L
F
D
A
I
T
S
--
T
N
----
K
Y
T
E
R
D
A
S
G
M
L
Y
N
L
A
S
A
I
K
Y
L
H
S
L
N
I
V
H
R
D
I
K
P
E
N
L
L
V
Y
---------
E
H
Q
D
G
S
K
S
------------------------
L
K
L
G
D
F
G
L
A
-
T
I
V
D
--
G
-
P
L
Y
T
V
C
G
T
P
T
Y
V
A
P
E
I
I
---
A
E
T
G
Y
G
---------
L
K
V
D
I
W
A
A
G
V
I
T
Y
I
L
L
C
G
F
P
P
F
R
G
---
S
--
D
Q
E
V
L
F
D
Q
I
L
M
G
Q
V
-
D
F
P
S
P
Y
W
D
N
V
S
D
S
A
K
E
L
I
T
M
M
L
L
V
D
V
D
Q
R
F
-----
S
A
V
Q
V
L
E
H
P
W
--------------------------------------------------------------------------------------------------------------------------------------------------------------
45
Fugue
62.59
26%
32
- C1 -
-
1KOB
1
?
A:
[23-374]
-----------------------------------------------------------------------------------------------------------------------------------INDYDK
F
Y
E
D
I
W
K
K
Y
V
P
Q
P
V
E
V
K
Q
G
S
V
Y
--
D
Y
Y
D
I
--
L
E
E
L
G
S
G
A
F
G
V
V
H
R
C
V
E
K
A
T
G
R
V
F
V
A
K
F
I
N
T
P
Y
--------
P
----
L
D
-
K
Y
T
V
K
N
E
I
S
I
M
N
Q
L
-
H
H
P
K
L
I
N
L
H
D
A
F
E
D
K
Y
E
M
V
L
I
L
E
F
L
-
S
G
G
-
E
L
F
D
R
I
A
A
--
E
D
Y---
K
M
S
E
A
E
V
I
N
Y
M
R
Q
A
C
E
G
L
K
H
M
H
E
H
S
I
V
H
L
D
I
K
P
E
N
I
M
C
E
-----------------------------------
T
K
K
A
S
S
V
K
I
I
D
F
G
L
A
-
T
K
L
N
P
D
E
-
I
V
K
V
T
T
A
T
A
E
F
A
A
P
E
I
V
D
------------
R
E
P
V
G
F
Y
T
D
M
W
A
I
G
V
L
G
Y
V
L
L
S
G
L
S
P
F
A
G
E
-----
D
D
L
E
T
L
Q
N
V
K
R
C
D
W
-
E
F
D
E
D
A
F
S
S
V
S
P
E
A
K
D
F
I
K
N
L
L
Q
K
E
P
R
K
R
L
-----
T
V
H
D
A
L
E
H
P
W
L
K
G
D
H
S
N
L
T
S
R
I
P
S
S
R
Y
N
K
I
--
R
Q
K
I
K
E
K
Y
A
D
W
P
A
P
Q
P
A
I
G
R
I
A
N
F
S
S
L
R
K
H
R
P
Q
E
Y
Q
I
Y
D
S
--------------------------------
Y
F
D
R
K
E
A
---------------------------------------------------------
3
PsiBlast_PDB
62.38
32%
-65
- C1 -
-
3NCG
1
?
A:
[29-326]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
A
S
A
K
------
N
----
K
D
-
T
S
T
I
L
R
E
V
E
L
L
K
K
L
-
D
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
-
T
-
G
G
E
L
F
D
E
I
I
K
--
R
K
----
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
----------------
E
S
K
E
K
------------------
D
C
D
I
K
I
I
D
F
G
L
S
-
T
C
F
Q
Q
N
T
------
I
G
T
A
Y
Y
I
A
P
E
V
L
R
G
T
Y
D
E
-------------
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
-----
G
K
N
E
Y
D
I
L
K
R
V
E
T
G
K
Y
-
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
-----
T
A
T
Q
C
L
E
H
P
W
I
Q
K
Y
S
S
E
T
P
T
----------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
62.25
32%
-61
- C1 -
-
4Y5Q
1
?
A:
[29-309]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
A
S
A
K
------
N
----
K
D
-
T
S
T
I
L
R
E
V
E
L
L
K
K
L
-
D
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
-
T
-
G
G
E
L
F
D
E
I
I
K
--
R
K
----
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
----------------
E
S
K
E
K
------------------
D
C
D
I
K
I
I
D
F
G
L
S
-
T
C
F
Q
Q
N
T
----
D
R
I
G
T
A
Y
Y
I
A
P
E
V
L
R
G
T
Y
D
E
-------------
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
-----
G
K
N
E
Y
D
I
L
K
R
V
E
T
G
K
Y
-
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
-----
T
A
T
Q
C
L
E
H
P
W
I
Q
K
Y
S
S
E
T
P
T
----------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
61.92
30%
-19
- C1 -
-
2X0G
-
DAPK1_HUMAN
A:
[6-280]
----------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
N
V
D
--
D
Y
Y
D
T
--
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
------
S
SRRG
V
S
-
R
E
D
I
E
R
E
V
S
I
L
K
E
I
-
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
-
A
G
G
-
E
L
F
D
F
L
A
E
--
K
E
----
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
---------------------------------
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
I
D
F
G
N
-
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
------------
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
-----
E
T
L
A
N
V
S
A
V
N
Y
-
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
D
T
--------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
61.77
33%
-16
- C1 -
-
2Y7J
1
PHKG2_HUMAN
C:
[92-364]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
F
Y
--
Q
K
Y
D
P
--
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
E
V
T
A
E
R
LSPEQL
E
----
E
V
-
R
E
A
T
R
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
M
F
L
V
F
D
L
M
-
R
K
G
-
E
L
F
D
Y
L
T
E
--
K
V
----
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
D
D
-------------------------------------
N
M
Q
I
R
L
S
D
F
G
F
S
-
C
H
L
E
P
G
E
-
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
C
S
M
D
E
------
T
H
P
G
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
R
R
Q
I
-----
L
M
L
R
M
I
M
E
G
Q
Y
-
Q
F
S
S
P
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
-----
T
A
E
Q
A
L
Q
H
P
F
F
E
------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
61.61
32%
-61
- C1 -
-
2WEI
1
?
A:
[29-283]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
A
S
A
K
------
N
----
K
D
-
T
S
T
I
L
R
E
V
E
L
L
K
K
L
-
D
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
-
T
-
G
G
E
L
F
D
E
I
I
K
--
R
K
----
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
----------------
E
S
K
E
K
------------------
D
C
D
I
K
I
I
D
F
G
L
S
-
T
C
F
Q
Q
N
T
-
K
M
K
D
R
I
G
T
A
Y
Y
I
A
P
E
V
L
R
G
T
Y
D
E
-------------
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
-----
G
K
N
E
Y
D
I
L
K
R
V
E
T
G
K
Y
-
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
-----
T
A
T
Q
C
L
E
H
P
W
I
Q
K
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
61.46
32%
-63
- C1 -
-
3IGO
8
?
A:
[29-304]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
A
S
A
K
------
N
----
K
--
T
S
T
I
L
R
E
V
E
L
L
K
K
L
-
D
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
-
T
-
G
G
E
L
F
D
E
I
I
K
--
R
K
----
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
----------------
E
S
K
E
K
------------------
D
C
D
I
K
I
I
D
F
G
L
S
-
T
C
F
Q
Q
N
T
--------
T
A
Y
Y
I
A
P
E
V
L
R
G
T
Y
D
E
-------------
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
-----
G
K
N
E
Y
D
I
L
K
R
V
E
T
G
K
Y
-
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
-----
T
A
T
Q
C
L
E
H
P
W
I
Q
K
Y
S
S
E
T
P
T
----------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
53.47
31%
-55
- C1 -
-
2JAM
3
KCC1G_HUMAN
A:
[15-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
I
K
K
S
-------------------
S
L
E
N
E
I
A
V
L
K
K
I
-
K
H
E
N
I
V
T
L
E
D
I
Y
E
S
T
T
H
Y
Y
L
V
M
Q
L
V
-
S
-
G
G
E
L
F
D
R
I
L
E
--
R
G
----
V
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
L
T
--------------------------------
P
E
E
--
N
S
K
I
M
I
T
D
F
G
L
S
-
K
--
M
E
Q
N
G
I
M
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
------
A
Q
K
P
Y
S
------
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
Y
E
E
T
E
S
-----
K
L
F
E
K
I
K
E
G
Y
Y
-
E
F
E
S
P
F
W
D
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
-----
T
C
E
K
A
L
S
H
P
W
--------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
53.46
32%
-16
- C1 -
-
3HZT
9
?
A:
[10-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
L
G
S
G
A
Y
G
E
V
L
L
C
K
D
K
L
T
G
A
E
R
A
I
K
I
I
K
K
S
S
V
T
------
T
T---
S
N
-
S
G
A
L
L
D
E
V
A
V
L
K
Q
L
-
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
R
N
Y
Y
L
V
M
E
V
Y
R
G
-
G
-
E
L
F
D
E
I
I
L
--
R
Q
----
K
F
S
E
V
D
A
A
V
I
M
K
Q
V
L
S
G
T
T
Y
L
H
K
H
N
I
V
H
R
D
L
K
P
E
N
L
L
L
----------------
E
S
K
S
R
------------------
D
A
L
I
K
I
V
D
F
G
L
S
-
A
H
F
E
V
G
---------
T
A
Y
Y
I
A
P
E
V
L
R
-------------
K
K
Y
D
E
K
C
D
V
W
S
C
G
V
I
L
Y
I
L
L
C
G
Y
P
P
F
G
G
Q
T
D
-----
Q
E
I
L
K
R
V
E
K
G
K
F
S
F
D
P
P
D
-
W
T
Q
V
S
D
E
A
K
Q
L
V
K
L
M
L
T
Y
E
P
S
K
R
I
-----
S
A
E
E
A
L
N
H
P
W
--------------------------------------------------------------------------------------------------------------------------------------------------------------