@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_35_1850: (2018-03-13 )
MPIGANASGGPSFQSGVNRTGNGTTRKNGMTINGIQNISMMGGRSEVAVKSAGNSVTQRVANLPTLPSTSASMQGLQSDFYSMPQPPMIHAGFQNGMMMPAYSGGYRQLSANGVRGTYRELNEMGEGGKVSTMQADDGKMRDADSVTPSLSPNSNVQNRCKVNTPPLAQADEYTGLTPTPPSLRFLTSYEEEEVRDYLPSVYFGGTEQCKKIHGVRGTEKNDGYDDDNFHYRVVVGDHLLYRYEVVKVLGQGTFGIVVRALDHKHHRLVAVKVIKNKPNYTKQAREEIKTLELLNRDDPDDEANIVRLLGSHIFRKHYILVFELLPSDLYAIIQTNKFRPMSHDFIYELSEQLLTALVHVRDHKIVHCDLKPENIMISRRGGNSNSLGESSDFSLKLIDFGSACEESRPLFTYIQSRYYRAPEIVLGIPYTTAIDMWSFGCVLCELANGYPIFPASSEGELLERLVEYFGTIPSYLVQQGRRADRFFEDGQMKHNLGKKRIPHAPHSRALRNFLKIGRSHEDQLFEDFVSKCLHLDARQRLTPEAALEHPWMELWRGTSSRGSTASLSDSCSLSR
Atome Classification :
(23 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180------.......190.......200.......210.......220.......230.......240.......250.......260-.-......270.......280.......290.......300.......310.......320.......330......-.340.......350.......360.--........370.......380...-------....390.......400......-.410.......420.......430.......440.......450.......460.......470.......480....--------------..---.---490.------.--------------.----------..-...-.500--..-.......510.-...--------------.-..520..-.....530.......540.......550.......560.......570...
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MPIGANASGGP
S
F
Q
SGVNRTGNGTTRKN
G
M
T
I
NGIQ
N
I
SMMGGR
S
E
V
A
V
KSA
G
N
S
V
T
Q
R
V
ANLPTLPS
T
S
A
S
M
Q
G
L
Q
S
D
F
YSMPQP
P
M
I
H
AGFQN
G
M
MMPAYSGG
Y
R
Q
LSANGVR
G
T
Y
R
E
L
N
EMGEGG
K
V
S
T
M
QADDGKMRDADSVTPSLSPNSNVQNRCKVNTPPLAQADEYTGLTPTPPS------
L
R
F
LTSY
E
E
E
E
V
R
D
YL
P
S
VYFG
G
T
E
Q
C
K
K
I
HGVRGTEKNDGYDDD
N
F
H
Y
R
V
V
VGD
H
L
L
Y
R
Y
E
V
V
K
V
L
GQG
T
F
G
I
V
V
R
A
LD-H-KH
H
R
L
V
A
V
K
V
IKNKPNY
T
K
Q
A
R
E
E
I
K
T
L
E
L
LNRDDPD
D
E
A
N
I
V
R
L
L
G
S
H
I
F
R
K
H
Y
I
L
V
F
ELL
P
S
D
L
Y
A
I
I
QTNKF-RPM
S
H
D
F
I
Y
E
L
S
E
Q
L
L
T
A
L
V
H
V--R--D
H
K
I
V
H
C
DLKPE
N
I
M
I
S
RRGGNSN-------SLGESSD
F
S
L
K
L
I
DFGS
A
C
EES
R
-
P
L
F
T
Y
I
Q
S
R
YYRAP
E
I
V
L
GIPYT
T
A
I
D
M
W
S
F
G
C
V
L
C
E
LANGYPIFPASSE
G
E
L
L
E
R
L
V
E
Y
FG
T
I
P
S
Y
L
V
QQGRRADRF--------------FE---D---G--
Q
------
M
--------------K----------HN-LGK-KR----IP-HA
P
H
S
R
A
L
R
N
F
-
L
K
I--------------G-RSH
E
D
Q
L
-
F
E
D
F
V
S
K
C
L
H
L
D
A
R
QRL
T
P
E
A
A
LE
H
P
W
M
E
L
WRGTSSRGSTASLSDSCSLSR
22
HHSearch
89.51
43%
-111
- C1 -
-
4AZF
2
DYRK2_HUMAN
A:
[90-413]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
H
-
K
V
H
Q
H
V
A
L
K
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
N
V
I
H
M
L
E
N
F
T
F
R
N
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
K
F
-
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
--
H
--
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
K
Q
Q
G
R
-----------------
S
G
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
-
R
V
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
D
A
S
K
R
A
K
N
F
--------------
V
S
---
S
---
K
--
G
------
Y
--------------
P
R
Y
C
T
V
T
TLS
D
V
V
-
L
N
G
-
G
R
SR
R
G
K
L
R
G
P
P
E
S
R
E
W
G
N
A
-
L
------------------
K
G
C
D
D
P
L
-
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
----------------------
21
HHSearch
88.39
42%
-103
- C1 -
-
5LXC
9
DYRK2_HUMAN
A:
[60-392]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
H
-
K
V
H
Q
H
V
A
L
K
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
N
V
I
H
M
L
E
N
F
T
F
R
N
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
K
F
-
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
--
H
--
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
K
Q
Q
G
R
-----------------
S
G
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
-
R
V
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
D
A
S
K
R
A
K
N
F
--------------
V
S
---
S
---
K
--
G
------
Y
PR
Y
C
T
V
T
T
LSD
G
S
V
V
L
N
--------
G
G
-
R
S
R
R
G
K
----
L
R
-
G
P
P
E
S
R
E
W
G
N
A
-
L
K
------------------
G
C
D
D
P
L
-
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
R
----------------------
23
HHSearch
79.60
39%
-51
* C1 *
-
4YU2
2
DYR1A_HUMAN
A:
[12-358]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
N
D
G
Y
D
D
D
N
Y
D
Y
I
V
K
N
G
E
K
W
M
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
-
V
E
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
Y
Y
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
-
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
--
A
TP
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
P
K
-----------------
R
S
A
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
-
R
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
A
P
K
A
R
K
F
--------------
F
E
---
K
LPD
G
--
T
------
W
--------------
N
L
K--------
K
T
-
K
D
G
-
K
R
----
E
Y
-
K
P
P
G
T
R
K
L
H
N
I
-
L
G
V
ETGGPGGRRAGES-
G
H
T
V
A
D
Y
L
K
-
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
T
--------------------
4
PsiBlast_PDB
77.63
39%
29
- C1 -
-
5LXD
6
DYRK2_HUMAN
A:
[9-391]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
M
T
P
E
Q
A
M
K
QY
M
Q
K
L
T
A
F
E
H
H
E
I
F
S
Y
-
P
E
I
Y
F
L
G
L
-
N
A
K
K
R
Q
G
M
T
G
G
P
N
N
G
G
Y
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
H
-
K
V
H
Q
H
V
A
L
K
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
N
V
I
H
M
L
E
N
F
T
F
R
N
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
K
F
-
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
--
H
--
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
K
Q
Q
G
R
S
-----------------
G
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
-
R
V
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
D
A
S
K
R
A
K
N
F
VSSKGYPR
Y
C
T
V
TT
L
S
---
D
---
G
--
S
------
V
--------------
V
----------
L
N
-
G
G
R
-
S
R
R
G
K
-
L
R
-
G
P
P
E
S
R
E
W
G
N
A
-
L
K
------------------
G
C
D
D
P
L
-
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
-----------------------
5
PsiBlast_PDB
76.56
39%
36
- C1 -
-
3K2L
-
DYRK2_HUMAN
A:
[29-412]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
P
M
T
P
E
Q
A
M
K
Q
Y
M
Q
K
L
T
A
F
E
H
H
E
I
F
S
Y
-
P
E
I
Y
F
L
G
L
-
N
A
K
K
R
Q
G
M
T
G
-
P
N
N
G
G
Y
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
H
-
K
V
H
Q
H
V
A
L
K
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
N
V
I
H
M
L
E
N
F
T
F
R
N
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
K
F
-
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
--
H
--
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
K
Q
Q
G
R
S
-----------------
G
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
-
R
V
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
D
A
S
K
R
A
K
N
F
VSSK
G
Y
P
R
Y
C
TVTT
L
S
---
D
---
G
--
S
------
V
--------------
V
----------
L
N
-
G
G
R
-
S
R
R
G
K
-
L
R
-
G
P
P
E
S
R
E
W
G
N
A
-
L
K
------------------
G
C
D
D
P
L
-
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
-----------------------
24
HHSearch
76.42
39%
-56
- C1 -
-
4YLL
10
DYR1A_HUMAN
A:
[12-357]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
N
D
G
Y
D
D
D
N
Y
D
Y
I
V
K
N
G
E
K
W
M
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
-
V
E
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
-
K
Y
Y
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
-
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
T
P
--
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
C
N
P
K
-----------------
R
S
A
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
-
R
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
A
P
K
A
R
K
F
--------------
F
E
---
K
LPD
G
--
T
------
W
--------------
N
L
K--------
K
------------
E
Y
-
K
P
P
G
T
R
K
L
H
N
I
-
L
G
V
ETGGPGGRRAGESG
H
-
T
V
A
D
Y
L
K
-
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
K
---------------------
2
PsiBlast_PDB
75.95
39%
30
- C1 -
-
4AZF
2
DYRK2_HUMAN
A:
[29-412]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
P
M
T
P
E
Q
A
M
K
Q
Y
M
Q
K
L
T
A
F
E
H
H
E
I
F
S
Y
-
P
E
I
Y
F
L
G
L
-
N
A
K
K
R
Q
G
M
T
G
G
P
N
N
G
G
Y
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
H
-
K
V
H
Q
H
V
A
L
K
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
N
V
I
H
M
L
E
N
F
T
F
R
N
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
K
F
-
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
--
H
--
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
K
Q
Q
G
R
S
-----------------
G
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
-
R
V
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
D
A
S
K
R
A
K
N
F
VSSKGYP
R
Y
C
T
V
T
T
L
S
---
D
-------------
V
--------------
V
----------
L
N
-
G
G
R
-
S
R
R
G
K
-
L
R
-
G
P
P
E
S
R
E
W
G
N
A
-
L
K
------------------
G
C
D
D
P
L
-
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
-----------------------
3
PsiBlast_PDB
75.77
39%
30
- C1 -
-
5LXC
10
DYRK2_HUMAN
A:
[9-391]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
M
T
P
E
Q
A
M
K
Q
Y
M
Q
K
L
T
A
F
E
H
H
E
I
F
S
Y
-
P
E
I
Y
F
L
G
L
-
N
A
K
K
R
Q
G
M
T
G
G
P
N
N
G
G
Y
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
H
-
K
V
H
Q
H
V
A
L
K
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
N
V
I
H
M
L
E
N
F
T
F
R
N
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
K
F
-
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
--
H
--
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
K
Q
Q
G
R
S
-----------------
G
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
-
R
V
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
D
A
S
K
R
A
K
N
F
VSSKGYPR
Y
C
T
V
T
T
L
S
---
D
---
G
--
S
------
V
--------------
V
----------
L
N
-
G
G
R
-
S
R
R
G
K
-
L
R
-
G
P
P
E
S
R
E
W
G
N
A
-
L
K
------------------
G
C
D
D
P
L
-
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
-----------------------
19
PsiBlast_PDB
75.54
35%
-57
- C1 -
-
4YLL
10
DYR1A_HUMAN
A:
[28-356]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
K
W
M
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
-
V
E
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
-
K
Y
Y
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
-
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
--
A
TP
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
-----------------
L
C
N
P
K
R
S
A
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
-
R
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
A
P
K
A
R
K
F
--------------
F
E
K
LP
D
---
G
T
W
N
------
L
--------------
K
----------
K
------------
E
Y
-
K
P
P
G
T
R
K
L
H
N
I
-
L
G
V
ETGGPGGRRAGES-
G
-
H
T
V
A
D
Y
L
K
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
----------------------
13
PsiBlast_PDB
75.52
35%
-57
- C1 -
-
5A4T
1
DYR1A_HUMAN
A:
[30-358]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
K
W
M
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
-
V
E
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
Y
Y
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
-
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
--
A
TP
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
-----------------
L
C
N
P
K
R
S
A
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
-
R
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
A
P
K
A
R
K
F
--------------
F
E
K
LP
D
---
G
T
W
N
------
L
--------------
K
----------
K
T
-----------
E
Y
-
K
P
P
G
T
R
K
L
H
N
I
-
L
G
V
ETGGPGGRRAGES-
G
-
H
T
V
A
D
Y
L
K
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
---
F
K
-------------------
8
PsiBlast_PDB
75.42
35%
-53
- C1 -
-
3ANR
1
DYR1A_HUMAN
A:
[30-359]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
K
W
M
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
-
V
E
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
Y
Y
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
-
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
--
A
TP
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
-----------------
L
C
N
P
K
R
S
A
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
-
R
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
A
P
K
A
R
K
F
--------------
F
E
K
LP
D
---
G
T
W
N
------
L
--------------
K
----------
K
T
-----------
E
Y
-
K
P
P
G
T
R
K
L
H
N
I
-
L
G
V
ETGGPGGRRAGES-
G
-
H
T
V
A
D
Y
L
K
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
---
F
K
K
------------------
15
PsiBlast_PDB
75.38
35%
-53
- C1 -
-
4MQ1
3
DYR1A_HUMAN
A:
[28-356]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
K
W
M
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
-
V
E
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
Y
Y
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
-
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
--
A
TP
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
-----------------
L
C
N
P
K
R
S
A
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
-
R
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
A
P
K
A
R
K
F
--------------
F
E
K
LP
D
---
G
TW
N
------
L
--------------
K
----------
K
T
-
K
D
G
-
K
R
----
E
Y
-
K
P
P
G
T
R
K
L
H
N
I
-
L
G
V
ETGGPGGRRAGES-
G
-
H
T
V
A
D
Y
L
K
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
----------------------
18
PsiBlast_PDB
75.33
35%
-57
- C1 -
-
4YLK
13
DYR1A_HUMAN
A:
[28-356]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
K
W
M
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
-
V
E
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
Y
Y
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
-
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
--
A
TP
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
-----------------
L
C
N
P
K
R
S
A
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
-
R
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
A
P
K
A
R
K
F
--------------
F
E
K
LP
D
---
G
T
W
N
------
L
--------------
K
----------
K
------------
E
Y
-
K
P
P
G
T
R
K
L
H
N
I
-
L
G
V
ETGGPGGRRAGES-
G
-
H
T
V
A
D
Y
L
K
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
----------------------
14
PsiBlast_PDB
75.19
35%
-55
- C1 -
-
5A54
1
DYR1A_HUMAN
A:
[30-358]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
K
W
M
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
-
V
E
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
Y
Y
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
-
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
--
A
TP
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
-----------------
L
C
N
P
K
R
S
A
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
-
R
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
A
P
K
A
R
K
F
--------------
F
E
K
LP
D
---
G
T
W
N
------
L
--------------
K
----------
K
T
-----------
E
Y
-
K
P
P
G
T
R
K
L
H
N
I
-
L
G
V
ETGGPGGRRAGES-
G
-
H
T
V
A
D
Y
L
K
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
---
F
K
-------------------
20
PsiBlast_PDB
75.00
35%
-51
- C1 -
-
4YU2
2
DYR1A_HUMAN
A:
[28-356]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
K
W
M
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
-
V
E
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
Y
Y
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
-
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
--
A
TP
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
-----------------
L
C
N
P
K
R
S
A
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
-
R
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
A
P
K
A
R
K
F
--------------
F
E
K
LP
D
---
G
T
W
N
------
L
--------------
K
----------
K
T
-
K
D
G
-
K
R
----
E
Y
-
K
P
P
G
T
R
K
L
H
N
I
-
L
G
V
ETGGPGGRRAGES-
G
-
H
T
V
A
D
Y
L
K
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
----------------------
12
PsiBlast_PDB
74.98
35%
-56
- C1 -
-
5A4Q
1
DYR1A_HUMAN
A:
[30-358]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
K
W
M
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
-
V
E
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
Y
Y
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
-
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
--
A
TP
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
-----------------
L
C
N
P
K
R
S
A
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
-
R
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
A
P
K
A
R
K
F
--------------
F
E
K
LP
D
---
G
T
W
N
------
L
--------------
K
----------
K
T
-----------
E
Y
-
K
P
P
G
T
R
K
L
H
N
I
-
L
G
V
ETGGPGGRRAGES-
G
-
H
T
V
A
D
Y
L
K
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
---
F
K
-------------------
9
PsiBlast_PDB
74.94
35%
-54
- C1 -
-
5A3X
1
DYR1A_HUMAN
A:
[30-359]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
K
W
M
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
-
V
E
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
Y
Y
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
-
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
--
A
TP
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
-----------------
L
C
N
P
K
R
S
A
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
-
R
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
A
P
K
A
R
K
F
--------------
F
E
K
LP
D
---
G
TW
N
------
L
--------------
K
----------
K
T
-----------
E
Y
-
K
P
P
G
T
R
K
L
H
N
I
-
L
G
V
ETGGPGGRRAGES-
G
-
H
T
V
A
D
Y
L
K
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
---
F
K
K
------------------
1
PsiBlast_PDB
74.81
39%
36
- C1 -
-
3KVW
1
DYRK2_HUMAN
A:
[29-412]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
P
M
T
P
E
Q
A
M
K
Q
Y
M
Q
K
L
T
A
F
E
H
H
E
I
F
S
Y
-
P
E
I
Y
F
L
G
L
-
N
A
K
K
R
Q
G
M
T
G
G
P
N
N
G
G
Y
D
D
D
Q
G
S
Y
V
Q
V
P
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
H
-
K
V
H
Q
H
V
A
L
K
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
D
K
D
N
T
M
N
V
I
H
M
L
E
N
F
T
F
R
N
H
I
C
M
T
F
E
L
L
S
M
N
L
Y
E
L
I
K
K
N
K
F
-
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
--
H
--
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
K
Q
Q
G
R
S
-----------------
G
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
-
R
V
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
D
A
S
K
R
A
K
N
F
VSSKGYP
R
Y
C
T
V
T
T
L
S
---
D
-------------
V
--------------
V
----------
L
N
-
G
G
R
-
S
R
R
G
K
-
L
R
-
G
P
P
E
S
R
E
W
G
N
A
-
L
K
------------------
G
C
D
D
P
L
-
F
L
D
F
L
K
Q
C
L
E
W
D
P
A
V
R
M
T
P
G
Q
A
L
R
H
P
W
L
-----------------------
7
PsiBlast_PDB
74.65
35%
-52
- C1 -
-
3ANQ
1
DYR1A_HUMAN
A:
[30-359]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
K
W
M
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
-
V
E
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
Y
Y
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
-
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
--
A
TP
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
-----------------
L
C
N
P
K
R
S
A
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
-
R
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
A
P
K
A
R
K
F
--------------
F
E
K
LP
D
---
G
T
W
N
------
L
--------------
K
----------
K
-------
R
----
E
Y
-
K
P
P
G
T
R
K
L
H
N
I
-
L
G
V
ETGGPGGRRAGES-
G
-
H
T
V
A
D
Y
L
K
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
---
F
K
K
------------------
17
PsiBlast_PDB
74.12
35%
-53
- C1 -
-
4YLJ
3
DYR1A_HUMAN
A:
[28-356]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
K
W
M
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
-
V
E
Q
E
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
N
K
H
D
T
E
M
K
Y
Y
I
V
H
L
K
R
H
F
M
F
R
N
H
L
C
L
V
F
E
M
L
S
Y
N
L
Y
D
L
L
R
N
T
N
F
-
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
--
A
TP
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
-----------------
L
C
N
P
K
R
S
A
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
-
R
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
A
H
I
L
D
Q
A
P
K
A
R
K
F
--------------
F
E
K
LP
D
---
G
T
W
N
------
L
--------------
K
----------
K
T
-
K
D
G
-
K
R
----
E
Y
-
K
P
P
G
T
R
K
L
H
N
I
-
L
G
V
ETGGPGGRRAGES-
G
-
H
T
V
A
D
Y
L
K
F
K
D
L
I
L
R
M
L
D
Y
D
P
K
T
R
I
Q
P
Y
Y
A
L
Q
H
S
F
F
K
----------------------
28
HHSearch
63.63
32%
-41
- C1 -
-
5J1W
6
CLK1_HUMAN
A:
[9-335]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
-
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
-
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
--
H
--
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
T
E
A
Y
N
PKIK
R
D
E
R
T
L
I
N
P
D
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
-
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
K
T
R
K
R
K
Y
F
--------------
H
H
-------
D
--
R
------
L
--------------
D
----------
W
D
E
H
S
S
-
A
G
----
R
Y
-
V
S
R
A
C
K
P
L
K
E
F
-
M
L
S
----------------
Q
D
V
E
H
E
R
-
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
--------------------
29
HHSearch
63.03
32%
-34
- C1 -
-
1Z57
1
CLK1_HUMAN
A:
[8-335]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
-
A
G
G
R
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
E
W
F
E
H
H
G
H
I
C
I
V
F
E
L
L
G
L
S
T
Y
D
F
I
K
E
N
G
F
-
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
--
H
--
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
V
Q
S
D
Y
T
E
A
Y
NR----
D
E
R
T
L
I
N
P
D
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
-
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
P
L
P
K
H
M
I
Q
K
T
R
K
R
K
Y
F
---------------
H
---
H
---
D
--
R
------
L
--------------
D
----------
W
D
E
H
S
S
-
A
G
----
R
Y
-
V
S
R
A
C
K
P
L
K
E
F
-
M
L
S
----------------
Q
D
V
E
H
E
R
-
L
F
D
L
I
Q
K
M
L
E
Y
D
P
A
K
R
I
T
L
R
E
A
L
K
H
P
F
F
D
L
L
--------------------
42
HHSearch
61.81
32%
-19
- C1 -
-
4IIR
1
PRP4B_HUMAN
A:
[18-350]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Y
Y
R
V
N
I
G
E
V
L
D
K
R
Y
N
V
Y
G
Y
T
G
Q
G
--
S
N
V
V
R
A
R
D
-
N
A
R
A
N
Q
E
V
A
V
K
I
I
R
N
N
E
L
M
Q
K
T
G
L
K
E
L
E
F
L
K
K
L
N
D
A
D
P
D
D
K
F
H
C
L
R
L
F
R
H
F
Y
H
K
Q
H
L
C
L
V
F
E
P
L
S
M
N
L
R
E
V
L
K
K
Y
G
K
D
V
G
L
H
I
K
A
V
R
S
Y
S
Q
Q
L
F
L
A
L
K
L
L
--
K
--
R
C
N
I
L
H
A
D
I
K
P
D
N
I
L
V
N
E
S
K
------------------
T
I
L
K
L
C
D
F
G
S
A
S
H
V
A
D
N
D
I
T
P
Y
L
V
S
R
F
Y
R
A
P
E
I
I
I
G
K
S
Y
D
Y
G
I
D
M
W
S
V
G
C
T
L
Y
E
L
Y
T
G
K
I
L
F
P
G
K
T
N
N
H
M
L
K
L
A
M
D
L
K
G
K
M
P
N
K
M
I
R
K
G
V
F
K
D
Q
H
--------------
F
D
---
Q
---
N
--
L
N
F
M
Y
IE-----------------------------
R
E
K
V
T
V
----
M
S
T
I
N
P
T
K
D
L
L
A
D
L
I
L
P
E
--------------
D
-
Q
R
K
K
V
H
Q
-
L
K
D
L
L
D
Q
I
L
M
L
D
P
A
K
R
I
S
I
N
Q
A
L
Q
H
A
F
I
Q
E
---------------------