@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_35_2370: (2018-03-13 )
MITSRGKASGHVKPSSPASAKDAAPFFAAAPTAVTASKTSYSRNDGHNPLINDLLKDLDKNSSPEDVHGAGHVQEQSVSNANSFSNFDLQLRRPSEESTASCRSSARNRDKTATDILCKTGQHFVHAMRMHNLEDFFCPAHGESAEDVLRRQLRKKDQEEVEAVVLTLVELLEEVRKARGQLVPLAGSLSLLDTSGRKRTSFNSMHSAVSTASLMRPPVHETNQLAMAYDQQGNRMINCYRVIANLGRGAYGKVKLGVDTNTGQMVAIKIIDKKLLKRIGGLGSSNQEAALKREIAIMKKVRHRNCVSLYEVIDDPDSHILYLIMEYVPNGPVVRLKPQELSSTALESIEAGIPLNGEVCNKALIRCAVRQSANGDTASLTDAEINSNPTIFLCKPLSQHICALYLRQLVSGLRYMHKRNLVHHDIKPDNILVGTNHHVFLSDFGVSEILSTRHEVKNAVKKNRGSMSDDLISEHSFESDGSDSTNDDGVGSKPRLGGGTLLFTAPELFDSSVNKKLLDPHLTDVWALGVTLYCMLVGMSPFFGNTYADVRANILTQRYPWCGKTIYGTLLAAEWRVVLNGLLAKNPNNRWSLARLKSFLDQHSFQYAMRQSAFLEASTRTRSLTSVDGDASPSTSTAQRAAGLAASSTGTFAKGLKLPLACSSVAKDKNASILLPRVVSSPRAVSALSMEAGGAARSFLWDLGVSEKEVRGATRTVKVEVVRQTTVLSAHTRTIVRRYVEWIRACMHARNFIPLGCAPPLSRKSLVGSLVSMQMCADANKSSKTLTASREKAHVTHVPVLAVAARCHRTSEAGPIGTRSSLFPPRRSPHSPAGDTRKGRQRSGSRSSNDGGGRALTRGSLESRASDGRLQSLDAALSIVNLQSTFDEHSLTFSLTSSSASSQASFSSQHGYSGQQPGRETRTNNGILAGNLATPSEDTPAPRNGMAEKVSWCNAQMPSTVAQTMVPSSATPSSIAEEDSRKRVGAKGSKSRFQQFMRRKKTPSGASVSDDLTSYQSTFAPKSNSAVSPLLDSVLCSGISGLGDSNSAGCCSTHHNPKTVSTTDRCLAAPPDEHLSVVQSPGSVGNKHPVGPMQERLSDGKLAVLALTSFEQVPHVTVSKRLSSVFRK
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280------.......290--.........300--........310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410......-.420.......430.--..--.----.----..440.......450.......460.......470.......480.......490.......500.......510.-.-.....520.......530.....-..540.--------......550.-----....-..560.......----------570.......580.......590----.....-.--.--.600...--....610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120.....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MITSRGKASGHVKPSSPASAKDAAPFFAAAP
T
A
V
T
ASKTSYSRNDGHN
P
L
I
N
D
L
L
K
D
LDKNSSPEDVHGAGHV
Q
E
QSVSNANSFSNF
D
L
Q
L
RRPSEE
S
T
A
S
C
R
S
SARNRDK
T
A
T
D
I
L
C
KT
G
Q
H
F
V
H
A
M
R
MH
N
L
E
D
FFCPAHGE
S
A
E
D
V
L
R
R
Q
L
RKK
D
Q
E
E
V
E
A
V
V
L
T
L
V
E
L
L
E
E
V
R
K
ARG
Q
L
V
PLAG
S
L
S
L
LDTSGRKRTS
F
N
S
M
H
S
A
V
S
T
A
S
LMRPPVHETN
Q
L
A
M
A
YDQQG
N
R
M
I
N
C
Y
R
V
I
A
NLGRGAY
G
K
V
K
L
G
V
DTNTG
Q
M
V
A
I
K
I
I
D
K
K
L
L
K
R
IGGL------GSS
N
Q
E
A
A
----
L
K
R
E
I
A
I
M
K
K
V
---RHR
N
C
V
S
L
Y
E
VIDDPD
S
H
I
L
Y
L
I
M
E
YVPNG
P
V
V
R
L
K
P
Q
E
L
S
S
T
A
L
E
S
I
EAGIPL
N
G
E
V
C
N
K
A
L
I
R
C
A
V
RQSANGDTASLTDAEINSN
P
T
I
F
L
CK
P
L
S
Q
H
I
C
A
L
Y
L
R
Q
L
V
S
G
L
R
Y
M
H
K
-RNLVHHDIKPD
N
I
L
V
--GT--N----
H
----
H
V
F
L
S
DF
G
V
S
E
I
L
S
T
R
H
E
V
K
N
A
V
K
KNRGSMS
D
D
L
I
S
EHSFESDGSDSTNDDGVGSKPRLGG
G
T
L
L
F
T
A
P
E
L
F
D
S
S
V-N-KKLLDPH
L
T
D
V
W
A
L
G
V
T
L
Y
C
M
L
V-GMSPFF--------GN
T
Y
A
D
V
R
A
N
-----
I
L
TQ-RYPWCG
K
T
I
Y
G
T
----------
L
L
A
A
E
W
R
V
V
L
N
G
L
L
AKNPNNR
W
-----
S
L
A
R
L
-
K
--
S
--
F
L
D
Q
H
S
F
--
Q
Y
A
M
R
Q
S
A
F
LEASTRT
R
S
L
TSVDGDASPST
S
T
A
Q
R
A
AGLAASSTGTFAKGLKLPL
A
C
S
S
VAKDKNA
S
I
L
L
P
R
VVSSPR
A
V
S
A
L
SMEAGG
A
A
R
S
F
L
W
DLGV
S
E
K
E
VRGA
T
R
T
V
K
V
E
V
V
R
Q
T
T
V
L
S
A
H
T
R
T
I
V
R
R
Y
V
E
W
I
R
A
C
M
H
AR
N
F
I
PLGCAPPL
S
R
K
S
L
V
G
S
L
V
S
M
Q
M
CADANKSSK
T
L
TASREKAHVTH
V
P
V
L
A
V
A
A
R
CHRTSEAGPIGTRSSLFPPRRSPHSPAGDTRKGRQRSGSRSSNDGGG
R
A
LTRGS
L
E
SRASDG
R
L
Q
S
L
D
A
A
L
S
I
V
N
L
Q
STFDEH
S
L
T
F
S
LTSSSASSQASFSSQHGYSGQQPGRETRTNN
G
I
L
AGNLATPSEDTPAPRN
G
M
A
E
K
V
S
W
CNAQM
P
S
T
V
A
Q
T
MVPSSAT
P
S
S
I
A
E
E
D
S
R
K
RVGAKG
S
K
S
R
F
Q
Q
F
M
R
RKKTPSGASV
S
D
D
L
T
S
Y
Q
S
TFAPKSNS
A
V
S
P
L
L
D
S
V
L
C
S
G
I
SGLGDSNSAGCCSTHHNPKTVSTTDRCLAAP
P
D
E
H
L
S
V
V
QSPGSVGNKHPV
G
P
M
Q
E
RLSDG
K
L
A
V
L
A
LT
S
F
E
QVPH
V
T
V
S
K
R
L
S
S
V
FRK
44
HHSearch
69.45
28%
-119
- C1 -
-
5J5T
1
M4K3_HUMAN
A:
[3-267]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
D
F
E
L
I
Q
R
I
G
S
G
T
Y
G
D
V
Y
K
A
R
N
V
N
T
G
E
L
A
A
I
K
V
I
K
L
E
P
---------------
G
E
D
F
A
V
----
V
Q
Q
E
I
I
M
M
K
D
C
---
K
H
P
N
I
V
A
Y
F
G
S
Y
L
R
R
D
--
K
L
W
I
C
M
E
F
C
G
G
G
S
L
Q
D
I
Y
H
V
------------------------------------------------------
T
G
P
L
S
E
L
Q
I
A
Y
V
S
R
E
T
L
Q
G
L
Y
Y
L
H
S
-
K
G
K
M
H
R
D
I
K
G
A
N
I
L
L
--
T
D
--
N
----
G
----
H
V
K
L
A
D
F
G
V
S
A
Q
I
T
A
T
I
A
----------------------------------------
A
F
I
G
T
P
Y
W
M
A
P
E
V
A
A
V
E
R
----
K
G
G
Y
N
Q
L
C
D
L
W
A
V
G
I
T
A
I
E
L
A
E
-
L
Q
P
P
M
F
--------
D
L
H
P
M
R
A
L
F
L
-----
M
T
K
S
-
N
F
Q
P
P
K
-
L
K
D
K
M
----------
K
W
S
N
S
F
H
H
F
V
K
M
A
L
T
K
N
P
K
K
R
P
-----
T
A
E
K
L
-
L
--
Q
HP
F
V
T
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
67.56
29%
-155
- C1 -
-
5K00
1
MELK_HUMAN
A:
[6-258]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
--
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
N
T
L
--------------
G
S
D
L
P
R
----
I
K
T
E
I
E
A
L
K
N
L
---
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
--
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
------------------------------------------------------
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
-
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
--
D
E
--
Y
----
H
----
K
L
K
L
I
D
F
G
L
C
A
K
P
-------------------------------------------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
------
S
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
-
G
F
L
P
F
D
--------
D
D
N
V
M
A
L
Y
K
K
-----
I
M
R
G
-
K
Y
D
V
P
------
K
----------
W
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
-
L
--
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
67.25
27%
-70
- C1 -
-
4GV1
5
AKT1_HUMAN
A:
[7-279]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
A
T
G
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
------------
A
K
D
E
V
A
H
----
T
L
T
E
N
R
V
L
Q
N
S
---
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
--
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
------------------------------------------------------
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
--
D
K
--
D
----
G
----
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
A
-------------------------------------
T
M
K
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
-------
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
-
G
R
L
P
F
Y
--------
N
Q
D
H
E
K
L
F
E
L
-----
I
L
M
E
-
E
I
R
F
P
------
R
----------
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
GGGS
E
D
A
K
E
I
-
M
--
Q
HR
F
F
A
G
I
V
W
--
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
67.17
27%
-69
- C1 -
-
2X0G
-
DAPK1_HUMAN
A:
[9-278]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
S
S
---------
R
R
G
V
S
R
E
D
----
I
E
R
E
V
S
I
L
K
E
I
---
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
--
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
------------------------------------------------------
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
-
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
D
--
R
----
N
VP
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
N
E
--------------------------------------
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
-------
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
-
G
A
S
P
F
L
--------
G
D
T
K
Q
E
T
L
A
N
-----
V
S
A
V
-
N
Y
E
F
E
D
--
E
Y
F
S
----------
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
-
L
--
Q
HP
W
I
K
P
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
Fugue
66.48
23%
-45
- C1 -
-
1TKI
-
TITIN_HUMAN
A:
[18-338]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
L
Y
E
K
Y
M
I
A
E
D
L
G
R
G
E
F
G
I
V
H
R
C
V
E
T
S
S
K
K
T
Y
M
A
K
F
V
K
V
K
----------------
G
T
D
Q
V
L
----
V
K
K
E
I
S
I
L
N
I
A
---
R
H
R
N
I
L
H
L
H
E
S
F
E
S
M
E
--
E
L
V
M
I
F
E
F
I
S
G
L
------------
D
I
F
E
R
I
N
T
S
-----------------------------------------
A
F
E
L
N
E
R
E
I
V
S
Y
V
H
Q
V
C
E
A
L
Q
F
L
H
S
-
H
N
I
G
H
F
D
I
R
P
E
N
I
I
Y
--
Q
T
--
R
----
R
SS--
T
I
K
I
I
E
F
G
Q
A
R
Q
L
K
P
G
D
N
F
R
L
L
F
--------------------------------------
T
A
P
E
Y
Y
A
P
E
V
H
Q
H
D
V
-
V
------
S
T
A
T
D
M
W
S
L
G
T
L
V
Y
V
L
L
S
-
G
I
N
P
F
L
--------
A
E
T
N
Q
Q
I
I
E
N
-----
I
M
N
A
-
E
Y
T
F
D
E
E
A
F
K
E
------------
I
S
I
E
A
M
D
F
V
D
R
L
L
V
K
E
R
K
S
R
M
-----
T
A
S
E
A
-
L
Q
H
P
--
W
L
K
Q
K
I
E
--
R
V
S
T
K
V
I
R
T
L
K
H
R
R
Y
Y
H
T
L
I
K
K
D
L
N
M
V
V
S
A
A
R
I
S
C
G
G
A
I
R
S
Q
K
G
V
S
V
A
K
V
K
V
A
S
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
66.08
26%
-11
- C1 -
-
5UYJ
1
KKCC2_HUMAN
A:
[4-283]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
Q
Y
T
L
K
D
E
I
G
K
G
S
Y
G
V
V
K
L
A
Y
N
E
N
D
N
T
Y
Y
A
M
K
V
L
S
K
K
K
L
I
R
Q
A
G
F
PRRPP---
C
I
Q
P
R
G
PI
E
Q
V
Y
Q
E
I
A
I
L
K
K
L
---
D
H
P
N
V
V
K
L
V
E
V
L
D
D
P
N
E
D
H
L
Y
M
V
F
E
L
V
N
Q
G
P
V
M
E
V
----------------------------------------------------
P
T
L
---
K
P
L
S
E
D
Q
A
R
F
Y
F
Q
D
L
I
K
G
I
E
Y
L
H
Y
-
Q
K
I
I
H
R
D
I
K
P
S
N
L
L
V
--
G
E
--
D
----
G
----
H
I
K
I
A
D
F
G
V
S
N
-----------------------------
E
F
K
G
S
D
A
L
L
S
N
T
V
--------
G
T
P
A
F
M
A
P
E
S
L
--
S
E
-
T
-
R
K
I
F
S
G
K
A
L
D
V
W
A
M
G
V
T
L
Y
C
F
V
F
-
G
Q
C
P
F
M
--------
D
E
R
I
M
C
L
H
S
K
-----
I
K
S
Q
-
A
L
E
F
P
D
Q
P
D
--------------
I
A
E
D
L
K
D
L
I
T
R
M
L
D
K
N
P
E
S
R
I
-----
V
V
P
E
I
-
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
Fugue
65.34
22%
-34
- C1 -
-
1KOB
1
?
A:
[23-374]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
N
D
Y
D
K
F
Y
E
D
I
W
K
K
Y
V
P
Q
P
V
E
V
K
Q
G
S
V
Y
D
Y
Y
D
I
L
E
E
L
G
S
G
A
F
G
V
V
H
R
C
V
E
K
A
T
G
R
V
F
V
A
K
F
I
N
T
P
---------------
Y
P
L
D
K
Y
T
----
V
K
N
E
I
S
I
M
N
Q
L
---
H
H
P
K
L
I
N
L
H
D
A
F
E
D
K
Y
--
E
M
V
L
I
L
E
F
L
S
G
G
--------
E
L
F
D
R
I
A
A
E
---------------------------------------------
D
Y
K
M
S
E
A
E
V
I
N
Y
M
R
Q
A
C
E
G
L
K
H
M
H
E
-
H
S
I
V
H
L
D
I
K
P
E
N
I
M
C
ET
K
K
--
A
----
S
----
S
V
K
I
I
D
F
G
L
A
T
K
L
N
P
D
E
I
V
K
V
T
T
--------------------------------------
A
T
A
E
F
A
A
P
E
I
V
D
R
E
P
-
V
------
G
F
Y
T
D
M
W
A
I
G
V
L
G
Y
V
L
L
S
-
G
L
S
P
F
A
--------
G
E
D
D
L
E
T
L
Q
N
-----
V
K
R
C
-
D
W
E
F
D
E
D
A
F
S
S
------------
V
S
P
E
A
K
D
F
I
K
N
L
L
Q
K
E
P
R
K
R
L
-----
T
V
H
D
A
-
L
--------
E
H
P
W
LK
G
D
H
S
N
L
T
S
R
I
P
S
S
R
Y
N
K
I
R
Q
K
I
K
E
K
Y
A
D
W
P
A
P
Q
P
A
I
G
R
I
A
N
F
S
S
L
R
K
H
R
P
Q
E
Y
Q
I
Y
D
S
Y
F
D
R
K
E
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
HHSearch
65.27
25%
-111
- C1 -
-
3C0G
1
CSKP_HUMAN
B:
[22-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
S
S
----------
P
G
L
S
T
E
D
----
L
K
R
E
A
S
I
C
H
M
L
---
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
--
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
--------------------------------------------------
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
-
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
--
A
S
--
K
ENS-
A
----
P
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
S
G
L
-------------------------------------
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
R
E
-------
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
-
G
C
L
P
F
Y
--------
G
T
K
E
R
-
L
F
E
G
-----
I
I
K
G
-
K
Y
K
M
N
P
--
R
Q
W
S
----------
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
-----
T
V
Y
E
A
-
L
--
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
64.02
26%
9
- C1 -
-
5UY6
1
KKCC2_HUMAN
A:
[4-283]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
Q
Y
T
L
K
D
E
I
G
K
G
S
Y
G
V
V
K
L
A
Y
N
E
N
D
N
T
Y
Y
A
M
K
V
L
S
K
K
K
L
I
R
Q
A
G
F
PRRPPP-
G
C
I
Q
P
R
G
PI
E
Q
V
Y
Q
E
I
A
I
L
K
K
L
---
D
H
P
N
V
V
K
L
V
E
V
L
D
D
P
N
E
D
H
L
Y
M
V
F
E
L
V
N
Q
G
P
V
M
E
V
----------------------------------------------------
P
T
L
---
K
P
L
S
E
D
Q
A
R
F
Y
F
Q
D
L
I
K
G
I
E
Y
L
H
Y
-
Q
K
I
I
H
R
D
I
K
P
S
N
L
L
V
--
G
E
--
D
----
G
----
H
I
K
I
A
D
F
G
V
S
N
-----------------------------
E
F
K
G
S
D
A
L
L
S
N
T
V
--------
G
T
P
A
F
M
A
P
E
S
L
--
S
E
-
T
-
R
K
I
F
S
G
K
A
L
D
V
W
A
M
G
V
T
L
Y
C
F
V
F
-
G
Q
C
P
F
M
--------
D
E
R
I
M
C
L
H
S
K
-----
I
K
S
Q
-
A
L
E
F
P
D
Q
P
D
--------------
I
A
E
D
L
K
D
L
I
T
R
M
L
D
K
N
P
E
S
R
I
-----
V
V
P
E
I
-
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
HHSearch
63.58
25%
-113
- C1 -
-
3C0I
1
CSKP_HUMAN
A:
[22-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
T
S
S
----------
P
G
L
S
T
E
D
----
L
K
R
E
A
S
I
C
H
M
L
---
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
--
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
--------------------------------------------------
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
-
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
--
A
S
--
K
ENS-
A
----
P
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
S
G
L
-------------------------------------
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
R
E
-------
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
-
G
C
L
P
F
Y
--------
G
T
K
E
R
-
L
F
E
G
-----
I
I
K
G
-
K
Y
K
M
N
P
--
R
Q
W
S
----------
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
-----
T
V
Y
E
A
-
L
--
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
62.29
25%
-82
- C1 -
-
1TKI
-
TITIN_HUMAN
A:
[20-274]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Y
E
K
Y
M
I
A
E
D
L
G
R
G
E
F
G
I
V
H
R
C
V
E
T
S
S
K
K
T
Y
M
A
K
F
V
K
V
K
G
----------------
T
D
Q
V
L
----
V
K
K
E
I
S
I
L
N
I
A
---
R
H
R
N
I
L
H
L
H
E
S
F
E
S
M
E
--
E
L
V
M
I
F
E
F
I
S
G
L
D
I
F
E
R
I
N
T
S
-----------------------------------------------------
A
F
E
L
N
E
R
E
I
V
S
Y
V
H
Q
V
C
E
A
L
Q
F
L
H
S
-
H
N
I
G
H
F
D
I
R
P
E
N
I
I
Y
--
Q
T
RR
S
----
S
----
T
I
K
I
I
E
F
G
Q
A
R
Q
L
K
P
G
D
N
--------------------------------------
F
R
L
L
F
T
A
P
E
Y
Y
A
P
E
V
H
Q
H
D
-------
V
V
S
T
A
T
D
M
W
S
L
G
T
L
V
Y
V
L
L
S
-
G
I
N
P
F
L
--------
A
E
T
N
Q
Q
I
I
E
N
-----
I
M
N
A
-
E
Y
T
F
D
E
E
--
A
F
K
----------
E
I
S
I
E
A
M
D
F
V
D
R
L
L
V
K
E
R
K
S
R
M
-----
T
A
S
E
A
-
L
--
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
Fugue
61.34
20%
-44
- C1 -
-
4EUT
1
TBK1_HUMAN
A:
[2-387]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
Q
S
T
S
N
-
H
L
W
L
L
S
D
I
L
G
Q
G
A
T
A
N
V
F
R
G
R
H
K
K
T
G
D
L
F
A
I
K
V
F
N
N
I
S
F
L
R
--------------
P
V
D
V
----
Q
M
R
E
F
E
V
L
K
K
L
---
N
H
K
N
I
V
K
L
F
A
I
E
E
E
T
T
T
R
H
K
V
L
I
M
E
F
C
P
C
G
S
L
Y
T
V
L
E
E
P
S
N
A
Y
G
L
---------------------------------------------------
P
E
S
E
F
L
I
V
L
R
D
V
V
G
G
M
N
H
L
R
E
-
N
G
I
V
H
R
N
I
K
P
G
N
I
M
R
--
V
I
--
G
EDG
Q
S
----
V
Y
K
L
T
D
F
G
A
A
R
E
L
E
D
D
E
Q
F
V
S
L
Y
--------------------------------------
G
T
E
E
Y
L
H
P
D
M
Y
E
R
A
V
L
D
-
H
Q
K
K
Y
G
A
T
V
D
L
W
S
I
G
V
T
F
Y
H
A
A
T
-
G
S
L
P
F
R
PFEGPRRN
K
E
V
M
Y
K
I
I
T
G
KPSGA
I
S
G
V
-
Q
K
A
E
N
G
P
I
D
W
S
G
DMPVSCSLS
R
G
L
Q
V
L
L
T
P
V
L
A
N
I
L
E
A
D
Q
E
K
C
W
-----
G
F
D
Q
F
-
F
--
A
--
E
T
S
D
I
L
H
--
R
M
V
I
H
V
F
S
L
Q
Q
M
T
A
H
K
I
Y
I
H
S
--------
Y
N
T
A
T
I
F
H
E
L
V
Y
K
Q
T
K
I
I
S
S
N
Q
E
L
I
Y
E
G
R
R
L
V
L
E
P
G
R
L
A
Q
H
F
P
K
T
T
E
E
N
P
I
F
V
V
S
R
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
60.80
29%
-80
- C1 -
-
2X4F
4
MYLK4_HUMAN
A:
[89-356]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
V
S
K
T
E
I
L
G
-----
Q
V
H
K
C
E
E
T
A
T
G
L
K
L
A
A
K
I
I
K
T
R
G
M
---------------
K
D
K
E
E
----
V
K
N
E
I
S
V
M
N
Q
L
---
D
H
A
N
L
I
Q
L
Y
D
A
F
E
S
K
--
N
D
I
V
L
V
M
E
Y
V
D
G
G
E
L
F
D
R
I
I
D
E
-----------------------------------------------------
S
Y
N
L
T
E
L
D
T
I
L
F
M
K
Q
I
C
E
G
I
R
H
M
H
Q
-
M
Y
I
L
H
L
D
L
K
P
E
N
I
L
C
VN
R
D
--
A
----
K
----
Q
I
K
I
I
D
F
G
L
A
R
R
Y
K
P
R
E
K
--------------------------------------
L
K
V
N
F
G
T
P
E
F
L
A
P
E
V
V
N
Y
D
-------
F
V
S
F
P
T
D
M
W
S
V
G
V
I
A
Y
M
L
L
S
-
G
L
S
P
F
L
--------
G
D
N
D
A
E
T
L
N
N
-----
I
L
A
C
-
R
W
D
L
E
D
--
E
E
F
Q
----------
D
I
S
E
E
A
K
E
F
I
S
K
L
L
I
K
E
K
S
W
R
I
-----
S
A
S
E
A
-
L
--
K
HP
W
L
S
D
H
K
L
--
H
S
R
L
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
60.32
29%
-172
- C1 -
-
4JXF
2
PLK4_HUMAN
A:
[5-258]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
E
D
F
K
V
G
N
L
L
G
K
G
S
F
A
G
V
Y
R
A
E
S
I
H
T
G
L
E
V
A
I
K
M
I
D
K
K
A
M
Y
------------
K
A
G
M
V
Q
R
----
V
Q
N
E
V
K
I
H
C
Q
L
---
K
H
P
S
I
L
E
L
Y
N
Y
F
E
D
S
--
N
Y
V
Y
L
V
L
E
M
C
H
N
G
E
M
N
R
Y
L
K
N
R
-----------------------------------------------------
V
K
P
F
S
E
N
E
A
R
H
F
M
H
Q
I
I
T
G
M
L
Y
L
H
S
-
H
G
I
L
H
R
D
L
T
L
S
N
L
L
L
--
T
R
--
N
----
M
----
N
I
K
I
A
D
F
G
L
A
T
Q
L
K
M
P
H
E
---------------------------------------------------------------------
S
D
V
W
S
L
G
C
M
F
Y
T
L
L
I
-
G
R
P
P
F
------------
V
K
N
T
L
N
K
-----
V
V
L
A
-
D
Y
E
M
P
------
S
----------
F
L
S
I
E
A
K
D
L
I
H
Q
L
L
R
R
N
P
A
D
R
L
-----
S
L
S
S
V
-
L
--
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
60.25
24%
-49
* C1 *
-
2Y7J
1
PHKG2_HUMAN
C:
[92-359]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
Y
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
E
V
T
A
E
R
L
S
-
P
E
------
Q
L
E
E
V
R
E
A
----
T
R
R
E
T
H
I
L
R
Q
V
A--
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
--
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
------------------------------------------------------
K
V
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
-
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
--
D
D
--
N
----
M
----
Q
I
R
L
S
D
F
G
F
S
C
H
L
E
P
G
E
K
--------------------------------------
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
C
S
M
-
D
E
T
H
P
G
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
-
G
S
P
P
F
W
--------
H
R
R
Q
I
L
M
L
R
M
-----
I
M
E
G
-
Q
Y
Q
F
S
S
P
--
E
W
D
----------
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
-----
T
A
E
Q
A
-
L
--
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
59.36
24%
-47
- C1 -
-
2Y7J
1
PHKG2_HUMAN
D:
[92-359]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
Y
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
E
V
---
R
L
S
-
P
E
------
Q
L
E
E
V
R
E
A
----
T
R
R
E
T
H
I
L
R
Q
V
A--
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
--
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
------------------------------------------------------
K
V
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
-
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
--
D
D
--
N
----
M
----
Q
I
R
L
S
D
F
G
F
S
C
H
L
E
P
G
E
K
--------------------------------------
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
C
S
M
-
D
E
T
H
P
G
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
-
G
S
P
P
F
W
--------
H
R
R
Q
I
L
M
L
R
M
-----
I
M
E
G
-
Q
Y
Q
F
S
S
P
--
E
W
D
----------
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
-----
T
A
E
Q
A
-
L
--
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
58.37
26%
-14
- C1 -
-
5VT1
1
KKCC2_HUMAN
A:
[4-283]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
Q
Y
T
L
K
D
E
I
G
K
G
S
Y
G
V
V
K
L
A
Y
N
E
N
D
N
T
Y
Y
A
M
K
V
L
S
K
K
K
L
I
R
Q
A
--------------
R
G
P
I
E
Q
V
Y
Q
E
I
A
I
L
K
K
L
---
D
H
P
N
V
V
K
L
V
E
V
L
D
D
P
N
E
D
H
L
Y
M
V
F
E
L
V
N
Q
G
P
V
M
E
V
----------------------------------------------------
P
T
L
---
K
P
L
S
E
D
Q
A
R
F
Y
F
Q
D
L
I
K
G
I
E
Y
L
H
Y
-
Q
K
I
I
H
R
D
I
K
P
S
N
L
L
V
--
G
E
--
D
----
G
----
H
I
K
I
A
D
F
G
V
S
N
-----------------------------
E
F
K
G
S
D
A
L
L
S
N
T
V
--------
G
T
P
A
F
M
A
P
E
S
L
--
S
-----
K
I
F
S
G
K
A
L
D
V
W
A
M
G
V
T
L
Y
C
F
V
F
-
G
Q
C
P
F
M
--------
D
E
R
I
M
C
L
H
S
K
-----
I
K
S
Q
-
A
L
E
F
P
D
Q
P
D
--------------
I
A
E
D
L
K
D
L
I
T
R
M
L
D
K
N
P
E
S
R
I
-----
V
V
P
E
I
-
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
57.85
26%
2
- C1 -
-
2ZV2
1
KKCC2_HUMAN
A:
[12-291]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
Q
Y
T
L
K
D
E
I
G
K
--
Y
G
V
V
K
L
A
Y
N
E
N
D
N
T
Y
Y
A
M
K
V
L
S
K
K
----------------------E
Q
--
V
Y
Q
E
I
A
I
L
K
K
L
---
D
H
P
N
V
V
K
L
V
E
V
L
D
D
P
N
E
D
H
L
Y
M
V
F
E
L
V
N
Q
G
P
V
M
E
V
----------------------------------------------------
P
T
L
---
K
P
L
S
E
D
Q
A
R
F
Y
F
Q
D
L
I
K
G
I
E
Y
L
H
Y
-
Q
K
I
I
H
R
D
I
K
P
S
N
L
L
V
--
G
E
--
D
----
G
----
H
I
K
I
A
D
F
G
V
S
N
-----------------------------
E
F
K
G
S
D
A
L
L
S
N
T
V
--------
G
T
P
A
F
M
A
P
E
S
L
--
S
E
-
T
-
R
K
I
F
S
G
K
A
L
D
V
W
A
M
G
V
T
L
Y
C
F
V
F
-
G
Q
C
P
F
M
--------
D
E
R
I
M
C
L
H
S
K
-----
I
K
S
Q
-
A
L
E
F
P
D
Q
P
D
--------------
I
A
E
D
L
K
D
L
I
T
R
M
L
D
K
N
P
E
S
R
I
-----
V
V
P
E
I
-
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
HHSearch
56.64
28%
-32
- C- -
-
4OTD
-
PKN1_HUMAN
A:
[617-886]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
E
D
F
K
F
L
A
V
L
G
R
G
H
F
G
K
V
L
L
S
E
F
R
P
S
G
E
L
F
A
I
K
A
L
K
K
G
D
I
V
------------
A
R
D
E
V
E
S
----
L
M
C
E
K
R
I
L
A
A
V
TSA
G
H
P
F
L
V
N
L
F
G
C
F
Q
T
P
E
--
H
V
C
F
V
M
E
Y
S
A
G
G
D
L
M
L
H
I
H
S
-------------------------------------------------------
D
V
F
S
E
P
R
A
I
F
Y
S
A
C
V
V
L
G
L
Q
F
L
H
E
-
H
K
I
V
Y
R
D
L
K
L
D
N
L
L
L
--
D
T
--
E
----
G
----
Y
V
K
I
A
D
F
G
L
C
K
E
G
M
G
Y
G
D
-------------------------------------
R
T
S
T
F
C
G
T
P
E
F
L
A
P
E
V
L
T
D
T
-------
S
Y
T
R
A
V
D
W
W
G
L
G
V
L
L
Y
E
M
L
V
-
G
E
S
P
F
P
--------
G
D
D
E
E
E
V
F
D
S
-----
I
V
N
D
-
E
V
R
Y
P
R
----------------
F
L
S
A
E
A
I
G
I
M
R
R
L
L
R
R
N
P
E
R
R
L
-----
G
S
S
E
R
D
A
--
E
--
D
V
K
K
Q
P
F
--
F
R
T
L
G
W
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
56.27
23%
-84
- C1 -
-
3BKB
7
A:
[113-371]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
E
D
L
V
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
R
A
D
N
T
L
V
A
V
K
S
C
R
E
T
L
P
--------------
P
D
L
K
A
K
----
F
L
Q
E
A
R
I
L
K
Q
Y
---
S
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
--
Q
P
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
E
-----------------------------------------------------
G
A
R
L
R
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
-
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
--
T
E
--
K
----
N
----
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
V
Y
A
-----------------------------------
A
S
G
G
L
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
-------
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
--------
N
L
S
N
Q
Q
T
R
E
F
-----
V
E
K
G
G
R
L
P
C
P
------
E
----------
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
-----
S
F
S
T
I
-
Y
--
Q
--
E
L
Q
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------