@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_35_5160: (2018-03-13 )
MPPKEVEHGSASTELLNQYAKYFPHVLFTSDEAFEKHAATLDPEAYKNCVDLPEGEEPPESNPREHMYVLTTLVGRNPTTAAFVATRGSDPSEKVVAKFVMLNDDRQATYARSELHCLAACKHFGIVKHFDDFKSDDKLLLIMEYGSGGDLNKQIKQRLKEHLPFQEYEVGLLFYQIVLALDEVHSRRMMHRDLKSANIFLMPTGIIKLGDFGFSKQYSDSVSLDVASSFCGTPYYLAPELWERKRYSKKADMWSLGVILYELLTLHRPFKGPSQREIMQQVLYGKYDPFPCPVSSSMQALLDPLLSKNPNERPTTQQLLHTEFLKYVANLFQDIVRHSETISPSDRTEILRQLQESGERAPLPSSIRYGVMTSQVTHGGYLYKYGSDYRWKKRYFYIGDGQLRISLSENPENDGVAPKSVNLETVGDVFPVPEVYSQKHPNQLVLWFNNGQKIIAYANTMEDRDMWISKFHRACGM
Atome Classification :
(36 SA)
.........10........20........30........40........50........60........70........80........90........100.--.--------.------....110.......120........130.--.--.....140.......150.......160.......170.......180....-..-----.190.......200-.--.--.---.----....210.......220...---------------....230.......240.------.------..----...250.......260.......270---........280....---.----.---.---290.---......300.......310---..-----.....320.......330.......340.......350.......360.......370.......380.......390.......400.......410..-.....420.......430.......440.......450.......460.......470.....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
P
P
K
EVEHGS
A
S
T
E
L
L
N
Q
Y
A
K
YFP
H
V
L
FTS
D
E
A
F
E
K
H
AATL
D
P
E
A
Y
K
N
CVDLPEGEEPPESNPR
E
H
M
Y
V
L
T
T
L
VGRNPT
T
A
A
F
V
A
TRGSD
P
S
E
K
V
V
A
K
F
V
M
LN--D--------D------RQ
A
T
Y
A
R
S
E
L
H
C
L
A
A
C
-
K
HF
G
I
V
K
H
F
D
DF--K--SD
D
K
L
L
L
I
M
EYGSGG
D
L
N
K
Q
I
K
Q
R
L
K
EHL
P
F
Q
E
Y
E
V
G
L
L
F
Y
Q
I
V
L
A
L
D
E
V
H
S
-
R
R
-----
M
M
H
R
DLKSA
N
I
F
L
--M--P--T---
G
----
I
I
K
LGDFGFSKQYSDSV
S
L
D
---------------
V
A
S
S
FCGTPYYL
A
P
E
L
W
E
------
R
------
K
R----YSKKA
D
M
W
S
L
G
V
I
L
Y
E
L
L
T
L
HRPFK----GP
S
Q
R
E
I
M
Q
Q
V
LYGK---Y----D---P---FPCP---
V
S
S
S
M
Q
A
L
L
D
P
L
L
SKNPNE---R
P
-----
T
T
Q
Q
L
L
H
T
E
F
L
K
Y
V
A
N
L
F
Q
D
I
V
R
HSETIS
P
S
D
R
T
E
I
L
R
Q
L
Q
ESGERAPLPSSIRYG
V
M
T
SQVTHG
G
Y
L
Y
KYGSD
Y
R
W
K
K
R
Y
F
Y
IGD
G
Q
L
R
I
SLSENPEND-GVAPKSVNLETVGDVFPV
P
E
V
Y
SQKHP
N
Q
L
V
L
W
FNNG
Q
K
I
I
A
Y
ANTM
E
D
R
D
M
W
I
S
K
F
H
R
A
CGM
28
HHSearch
81.30
28%
-69
- C1 -
-
5J5T
1
M4K3_HUMAN
A:
[3-268]
----------------------------------------------------------------
Q
E
D
F
E
L
I
Q
R
I
G
S
G
T
Y
G
D
V
Y
K
A
R
N
V
N
T
G
-
E
L
A
A
I
K
V
I
K
L
E
--
P
--------
G
------
E
D
F
A
V
V
Q
Q
E
I
I
M
M
K
D
C
-
K
H
P
N
I
V
A
Y
F
G
S
Y
--
L
--
R
R
D
K
L
W
I
C
M
E
F
C
G
G
G
S
L
Q
D
I
Y
H
V
T
----
G
P
L
S
E
L
Q
I
A
Y
V
S
R
E
T
L
Q
G
L
Y
Y
L
H
S
-
K
G
-----
K
M
H
R
D
I
K
G
A
N
I
L
L
--
T
--
D
--
N
---
G
----
H
V
K
L
A
D
F
G
V
S
A
Q
I
T
A
T
I
--
A
------------------
A
F
I
G
T
P
Y
W
M
A
P
E
V
A
A
V
ER---
K
------
G
G
----
Y
N
Q
L
C
D
L
W
A
V
G
I
T
A
I
E
L
A
E
L
Q
P
P
M
F
----
D
L
H
P
M
R
A
L
F
L
M
T
K
S
N
---
F
Q
P
P
K
L
---
K
---
D
K
M
K
---
W
S
N
S
F
H
H
F
V
K
M
A
L
T
K
N
P
K
K
---
R
P
-----
T
A
E
K
L
L
Q
H
P
F
V
T
Q
H
------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
79.77
28%
-76
- C1 -
-
4XBR
1
INKA1_HUMAN (first)
A:
[93-350]
----------------------------------------------------------------
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
-
K
L
V
A
V
K
K
M
D
L
R
--
K
--------
Q
------
Q
R
R
E
L
L
F
N
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
--
L
--
V
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
T
-----
R
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
-
Q
G
-----
V
I
H
R
D
I
K
S
D
S
I
L
L
--
T
--
H
--
D
---
G
----
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
--
P
---------------
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
------
R
------
L
P
----
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
----
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
---
P
----
P
RL-
K
---
N
L
H
K
---
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
---
R
A
-----
T
A
A
E
L
L
K
H
P
F
L
A
K
A
------------------------------------------------------------------------------------------------------------------------------------------------------
47
Fugue
77.87
21%
-23
- C1 -
-
1KOB
1
?
A:
[23-374]
------------------------------
I
N
D
Y
D
K
F
Y
E
D
I
W
K
K
Y
V
P
Q
P
V
-------
E
V
K
Q
G
S
V
Y
D
Y
Y
D
I
L
E
E
L
G
S
G
A
F
G
V
V
H
R
C
V
E
K
A
T
-
G
R
V
F
V
A
K
F
I
N
T
P
--
Y
--------
P
------
L
D
K
Y
T
V
K
N
E
I
S
I
M
N
Q
L
-
H
H
P
K
L
I
N
L
H
D
A
F
--
E
--
D
K
Y
E
M
V
L
I
L
E
F
L
S
G
G
E
L
F
D
R
I
---
A
A
E
D
Y
K
M
S
E
A
E
V
I
N
Y
M
R
Q
A
C
E
G
L
K
H
M
H
E
-
H
S
-----
I
V
H
L
D
I
K
P
E
N
I
M
C
--
E
TK
K
--
A
---
S
----
S
V
K
I
I
D
F
G
L
A
T
K
L
N
P
D
E
I
V
K
---------------
V
T
---
T
A
T
A
E
F
A
A
P
E
I
V
D
------
R
------
E
P
----
V
G
F
Y
T
D
M
W
A
I
G
V
L
G
Y
V
L
L
S
G
L
S
P
F
A
----
G
E
D
D
L
E
T
L
Q
N
V
K
R
C
D
---
W
----
E
---
F
---
D
E
D
A
FSS
V
S
P
E
A
K
D
F
I
K
N
L
L
Q
K
E
P
R
K
---
R
L
-----
T
V
H
D
A
L
E
H
P
W
L
K
G
D
H
S
-------
N
L
T
S
R
I
P
S
S
R
Y
N
K
I
R
Q
K
I
K
E
K
Y
A
D
W
P
A
P
Q
P
A
I
G
R
I
A
N
--------------------------------------------------------
F
S
S
L
R
K
H
R
P
Q
E
Y
Q
I
Y
D
S
Y
F
D
R
K
E
A
------------------------
24
HHSearch
75.53
29%
-16
- C1 -
-
3C0I
1
CSKP_HUMAN
A:
[21-294]
--------------------------------------------------------------
L
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
-
Q
Q
F
A
V
K
I
V
D
V
A
--
K
F
T
S
SP---
G
------
L
S
T
E
D
L
K
R
E
A
S
I
C
H
M
L
-
K
H
P
H
I
V
E
L
L
E
T
Y
--
S
--
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
-
N
N
-----
I
I
H
R
D
V
K
P
H
C
V
L
L
--
A
--
S
--
K
ENS
A
----
P
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
S
G
--
L
---------------
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
------
R
------
E
P
----
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
----
G
T
K
E
R
-
L
F
E
G
I
I
K
G
K
---
Y
----
K
---
M
N
PR
Q
W
S
H
---
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
---
R
I
-----
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
-----------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
75.23
27%
-12
* C1 *
-
2Y7J
1
PHKG2_HUMAN
C:
[92-364]
---------------------------------------------------------------
F
Y
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
-
H
E
F
A
V
K
I
M
E
V
T
--
A
ERLSPEQL
E
------
E
V
R
E
A
T
R
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
--
E
--
S
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
----
V
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
-
N
N
-----
I
V
H
R
D
L
K
P
E
N
I
L
L
--
D
--
D
--
N
---
M
----
Q
I
R
L
S
D
F
G
F
S
C
H
L
E
P
G
---
E
---------------
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
CSMDET
H
------
P
G
----
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
----
H
R
R
Q
I
L
M
L
R
M
I
M
E
G
Q
---
Y
----
Q
---
F
SSP
E
W
D
D
---
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
---
R
L
-----
T
A
E
Q
A
L
Q
H
P
F
F
E
--------------------------------------------------------------------------------------------------------------------------------------------------------
45
Fugue
74.33
23%
-33
- C1 -
-
1TKI
-
TITIN_HUMAN
A:
[18-338]
-------------------------------------------------------------
K
E
L
Y
E
K
Y
M
I
A
E
D
L
G
R
G
E
F
G
I
V
H
R
C
V
E
T
S
S
-
K
K
T
Y
M
A
K
F
V
K
V
K
--
G
---------------
T
D
Q
V
L
V
K
K
E
I
S
I
L
N
I
A
-
R
H
R
N
I
L
H
L
H
E
S
F
--
E
--
S
M
E
E
L
V
M
I
F
E
F
I
S
G
L
D
I
F
E
R
I
---
N
T
S
A
F
E
L
N
E
R
E
I
V
S
Y
V
H
Q
V
C
E
A
L
Q
F
L
H
S
-
H
N
-----
I
G
H
F
D
I
R
P
E
N
I
I
Y
--
Q
TR
R
--
S
---
S
----
T
I
K
I
I
E
F
G
Q
A
R
Q
L
K
P
G
---
D
---------------
N
F
R
L
L
F
T
A
P
E
Y
Y
A
P
E
V
H
Q
------
H
------
D
V
----
V
S
T
A
T
D
M
W
S
L
G
T
L
V
Y
V
L
L
S
G
I
N
P
F
L
----
A
E
T
N
Q
Q
I
I
E
N
I
M
N
A
E
---
Y
TFDE
E
---
A
---
F
K
-
E
---
I
S
I
E
A
M
D
F
V
D
R
L
L
V
K
E
R
K
S
---
R
M
-----
T
A
S
E
A
L
Q
H
P
W
L
K
Q
K
I
E
R
V
S
-----
T
K
V
I
R
T
L
K
H
R
R
Y
Y
H
T
L
I
K
K
D
L
N
M
V
---------------------------------------------------------------------------------------
V
S
A
A
R
I
S
C
G
G
A
I
R
S
Q
K
G
V
S
V
A
K
V
K
V
A
S
I
-
23
HHSearch
74.14
29%
-11
- C1 -
-
3C0G
1
CSKP_HUMAN
B:
[21-294]
--------------------------------------------------------------
L
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
-
Q
Q
F
A
V
K
I
V
D
V
A
--
K
F
T
S
SP---
G
------
L
S
T
E
D
L
K
R
E
A
S
I
C
H
M
L
-
K
H
P
H
I
V
E
L
L
E
T
Y
--
S
--
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
-
N
N
-----
I
I
H
R
D
V
K
P
H
C
V
L
L
--
A
--
S
--
K
ENS
A
----
P
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
S
G
--
L
---------------
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
------
R
------
E
P
----
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
----
G
T
K
E
R
-
L
F
E
G
I
I
K
G
K
---
Y
----
K
---
M
NPR
Q
W
S
H
---
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
---
R
I
-----
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
-----------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
71.64
27%
10
- C1 -
-
2Y7J
1
PHKG2_HUMAN
D:
[92-364]
---------------------------------------------------------------
F
Y
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
-
H
E
F
A
V
K
I
M
E
V
----RLSPEQL-
E
------
E
V
R
E
A
T
R
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
--
E
--
S
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
----
V
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
-
N
N
-----
I
V
H
R
D
L
K
P
E
N
I
L
L
--
D
--
D
--
N
---
M
----
Q
I
R
L
S
D
F
G
F
S
C
H
L
E
P
G
---
E
---------------
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
CSMDET
H
------
P
G
----
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
----
H
R
R
Q
I
L
M
L
R
M
I
M
E
G
Q
---
Y
----
Q
---
F
SSP
E
W
D
D
---
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
---
R
L
-----
T
A
E
Q
A
L
Q
H
P
F
F
E
--------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
71.62
26%
-74
- C1 -
-
1TKI
-
TITIN_HUMAN
A:
[20-283]
---------------------------------------------------------------
L
Y
E
K
Y
M
I
A
E
D
L
G
R
G
E
F
G
I
V
H
R
C
V
E
T
S
S
K
-
K
T
Y
M
A
K
F
V
K
V
K
--
G
---------------
T
D
Q
V
L
V
K
K
E
I
S
I
L
N
I
A
-
R
H
R
N
I
L
H
L
H
E
S
F
--
E
--
S
M
E
E
L
V
M
I
F
E
F
I
S
G
L
D
I
F
E
R
I
N
T
S
A
---
F
E
L
N
E
R
E
I
V
S
Y
V
H
Q
V
C
E
A
L
Q
F
L
H
S
-
H
N
-----
I
G
H
F
D
I
R
P
E
N
I
I
Y
--
Q
--
T
RR
S
---
S
----
T
I
K
I
I
E
F
G
Q
A
R
Q
L
K
P
G
---
D
---------------
N
F
R
L
L
F
T
A
P
E
Y
Y
A
P
E
V
H
Q
------
H
------
D
V
----
V
S
T
A
T
D
M
W
S
L
G
T
L
V
Y
V
L
L
S
G
I
N
P
F
L
----
A
E
T
N
Q
Q
I
I
E
N
I
M
N
A
E
---
Y
----
T
FDE
E
---
A
F
K
E
---
I
S
I
E
A
M
D
F
V
D
R
L
L
V
K
E
R
K
S
---
R
M
-----
T
A
S
E
A
L
Q
H
P
W
L
K
Q
K
I
E
----------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
71.32
26%
-72
- C1 -
-
2X4F
4
MYLK4_HUMAN
A:
[88-349]
----------------------------------------------------------------
F
Y
T
V
S
K
T
E
I
L
G
-----
Q
V
H
K
C
E
E
T
A
T
G
-
L
K
L
A
A
K
I
I
K
T
R
--
G
--------
M
------
K
D
K
E
E
V
K
N
E
I
S
V
M
N
Q
L
-
D
H
A
N
L
I
Q
L
Y
D
A
F
--
E
--
S
K
N
D
I
V
L
V
M
E
Y
V
D
G
G
E
L
F
D
R
I
I
D
E
S
---
Y
N
L
T
E
L
D
T
I
L
F
M
K
Q
I
C
E
G
I
R
H
M
H
Q
-
M
Y
-----
I
L
H
L
D
L
K
P
E
N
I
L
C
VN
R
--
D
--
A
---
K
----
Q
I
K
I
I
D
F
G
L
A
R
R
Y
K
P
R
E
------------------
K
L
K
V
N
F
G
T
P
E
F
L
A
P
E
V
V
N
------
Y
------
D
F
----
V
S
F
P
T
D
M
W
S
V
G
V
I
A
Y
M
L
L
S
G
L
S
P
F
L
----
G
D
N
D
A
E
T
L
N
N
I
L
A
C
R
---
W
----
D
LED
E
---
E
F
Q
D
---
I
S
E
E
A
K
E
F
I
S
K
L
L
I
K
E
K
S
W
---
R
I
-----
S
A
S
E
A
L
K
H
P
W
L
S
D
H
------------------------------------------------------------------------------------------------------------------------------------------------------
49
Fugue
70.26
19%
13
- C1 -
-
4EUT
1
TBK1_HUMAN
A:
[2-387]
----------------------------------------------------------
G
S
Q
S
T
S
N
H
L
W
L
L
S
D
I
L
G
Q
G
A
T
A
N
V
F
R
G
R
H
K
K
T
G
D
L
F
A
I
K
V
F
N
N
I
S
--
F
--------
L
------
R
P
V
D
V
Q
M
R
E
F
E
V
L
K
K
L
-
N
H
K
N
I
V
K
L
F
A
I
E
--
E
E
T
T
T
R
H
K
V
L
I
M
E
F
C
P
C
G
S
L
Y
T
V
L
E
E
P
S
N
A
Y
G
-
L
P
E
S
E
F
L
I
V
L
R
D
V
V
G
G
M
N
H
L
R
E
-
N
G
-----
I
V
H
R
N
I
K
P
G
N
I
M
R
--
V
--
I
--
G
---
E
DG
Q
S
V
Y
K
L
T
D
F
G
A
A
R
E
L
E
D
D
E
Q
F
------------------
V
S
L
Y
G
T
E
E
Y
L
H
P
D
M
Y
E
------
R
A
VLD
H
Q
K
K
----
Y
G
A
T
V
D
L
W
S
I
G
V
T
F
Y
H
A
A
T
G
S
L
P
F
R
PFEG
P
R
R
N
K
E
V
M
Y
K
I
I
T
G
K
---
P
----
S
---
G
------
A
---
I
S
G
V
Q
K
A
E
N
G
P
I
D
W
S
G
D
M
P
---
V
S
-----
C
S
---
L
S
R
G
L
Q
V
L
L
T
P
V
L
A
N
I
L
E
A
D
----
Q
E
K
C
W
G
-
F
D
Q
F
F
A
E
T
S
D
I
L
H
R
M
V
I
H
V
F
S
L
Q
Q
M
----------------
T
A
H
K
I
Y
I
H
S
Y
N
T
A
T
I
F
H
E
L
V
Y
K
Q
T
K
I
I
S
S
N
Q
E
L
I
Y
E
G
R
R
L
V
L
----------------
E
P
G
R
L
A
Q
H
F
P
K
T
T
E
E
N
P
I
F
V
V
S
R
E
-----
38
HHSearch
69.45
27%
-10
- C1 -
-
4GV1
5
AKT1_HUMAN
A:
[6-277]
---------------------------------------------------------------
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
A
T
G
-
R
Y
Y
A
M
K
I
L
K
K
E
--
V
I
V
A
-----
K
------
D
E
V
A
H
T
L
T
E
N
R
V
L
Q
N
S
-
R
H
P
F
L
T
A
L
K
Y
S
F
--
Q
--
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
----
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
-----
V
V
Y
R
D
L
K
L
E
N
L
M
L
--
D
--
K
--
D
---
G
----
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
--
A
---------------
T
M
K
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
------
D
------
N
D
----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
----
N
Q
D
H
E
K
L
F
E
L
I
L
M
E
E
---
I
--------
R
---
F
P
R
T
---
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
---
R
L
GGGS
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
-----------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
68.59
28%
-44
- C1 -
-
5K00
1
MELK_HUMAN
A:
[6-265]
---------------------------------------------------------------
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
--
A
K
V
K
L
A
C
H
I
L
T
G
-
E
M
V
A
I
K
I
M
D
K
N
--
T
L-------
G
------
S
D
L
P
R
I
K
T
E
I
E
A
L
K
N
L
-
R
H
Q
H
I
C
Q
L
Y
H
V
L
--
E
--
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
----
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
-
Q
G
-----
Y
A
H
R
D
L
K
P
E
N
L
L
F
--
D
--
E
--
Y
---
H
----
K
L
K
L
I
D
F
G
L
C
A
K
P
-----------------------------
S
L
A
Y
A
A
P
E
L
I
Q
------
G
------
K
S
Y---
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
----
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
K
---
Y
--------
D
---
V
P
K
W
---
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
---
R
I
-----
S
M
K
N
L
L
N
H
P
W
I
M
Q
D
------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
68.24
25%
-23
- C1 -
-
4WOT
1
ROCK2_HUMAN
B:
[67-340]
---------------------------------------------------------------
K
A
E
D
Y
D
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
A
S
Q
-
K
V
Y
A
M
K
L
L
S
K
F
--
E
M
I
K
-----
R
------
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
A
-
N
S
P
W
V
V
Q
L
F
Y
A
F
--
Q
--
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
-----
D
V
P
E
K
W
A
K
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
-----
L
I
H
R
D
V
K
P
D
N
M
L
L
--
D
--
K
--
H
---
G
----
H
L
K
L
A
D
F
G
T
C
M
K
M
D
E
T
G
-
M
V
---------------
H
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
------
S
------
Q
G
GDGF
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
----
A
D
S
L
V
G
T
Y
S
K
I
M
D
H
K
---
N
SLC-
F
---
P
---
E
D
A
E
---
I
S
K
H
A
K
N
L
I
C
A
F
L
T
D
R
E
V
R
LG-
R
N
-----
G
V
E
E
I
R
Q
H
P
F
F
K
N
D
Q
W
----------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
66.12
24%
-62
- C1 -
-
1KOB
1
?
A:
[49-312]
---------------------------------------------------------------
V
Y
D
Y
Y
D
I
L
E
E
L
G
S
G
A
F
G
V
V
H
R
C
V
E
K
A
T
G
-
R
V
F
V
A
K
F
I
N
T
P
--
Y
--------
P
------
L
D
K
Y
T
V
K
N
E
I
S
I
M
N
Q
L
-
H
H
P
K
L
I
N
L
H
D
A
F
--
E
--
D
K
Y
E
M
V
L
I
L
E
F
L
S
G
G
E
L
F
D
R
I
A
A
E
D
---
Y
K
M
S
E
A
E
V
I
N
Y
M
R
Q
A
C
E
G
L
K
H
M
H
E
-
H
S
-----
I
V
H
L
D
I
K
P
E
N
I
M
C
--
E
--
T
--
K
KA-
S
----
S
V
K
I
I
D
F
G
L
A
T
K
L
N
P
D
---
E
---------------
I
V
K
V
T
T
A
T
A
E
F
A
A
P
E
I
V
D
------
R
------
E
P
----
V
G
F
Y
T
D
M
W
A
I
G
V
L
G
Y
V
L
L
S
G
L
S
P
F
A
----
G
E
D
D
L
E
T
L
Q
N
V
K
R
C
D
---
W
E
F
D-
E
---
D
---
A
F
S
S
---
V
S
P
E
A
K
D
F
I
K
N
L
L
Q
K
E
P
R
K
---
R
L
-----
T
V
H
D
A
L
E
H
P
W
L
K
G
D
H
-----------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
64.99
28%
0
- C- -
-
2WEL
7
KCC2D_HUMAN
A:
[3-271]
----------------------------------------------------------------
T
D
E
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
-
Q
E
Y
A
A
K
I
I
N
T
K
KL
S
--------
A
------
R
D
H
Q
K
L
E
R
E
A
R
I
C
R
L
L
-
K
H
P
N
I
V
R
L
H
D
S
I
--
S
--
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
----
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
-
N
G
-----
I
V
H
R
D
L
K
P
E
N
L
L
L
--
A
--
S
--
K
SKG
A
----
A
V
K
L
A
D
F
G
L
A
I
E
V
Q
G
D
Q
--
Q
---------------
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
------
K
------
D
P
----
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
----
D
E
D
Q
H
R
L
Y
Q
Q
I
K
A
G
A
---
Y
----
D
FPS
P
---
E
W
D
T
---
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
---
R
I
-----
T
A
S
E
A
L
K
H
P
W
I
C
Q
R
------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
60.36
26%
21
- C1 -
-
2X0G
-
DAPK1_HUMAN
A:
[8-278]
--------------------------------------------------------------
N
V
D
D
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
-
L
Q
Y
A
A
K
F
I
K
K
R
--
R
--------
T
KSSRRG
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
-
Q
H
P
N
V
I
T
L
H
E
V
Y
--
E
--
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
----
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
-
L
Q
-----
I
A
H
F
D
L
K
P
E
N
I
M
L
--
L
--
D
--
R
---
N
VP
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
---
N
---------------
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
------
Y
------
E
P
----
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
----
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
N
YEF
E
----
D
---
E
---
Y
F
S
N
---
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
---
R
M
-----
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
58.96
35%
2
- C1 -
-
2W5B
1
NEK2_HUMAN
A:
[54-271]
--------------------------------------------------------------------------------------------------------------------------------
S
E
V
N
L
L
R
E
L
-
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
--
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
-
R
S
------
L
H
R
D
L
K
P
A
N
V
F
L
--
D
--
G
--
K
---
Q
----
N
V
K
L
G
D
F
G
L
A
R
I
L
N
H
D
T
S
F
-----------------
A
K
A
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
------
R
------
M
S
----
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
----
A
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
---
F
----
R
---
R
---
I
P
Y
R
---
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
---
R
P
-----
S
V
E
E
I
L
E
N
P
L
I
---------------------------------------------------------------------------------------------------------------------------------------------------------
43
HHSearch
58.60
25%
-13
- C1 -
-
4LQS
1
CBK1_YEAST
A:
[99-452]
--------------------------------------------------------------
L
S
L
E
D
F
H
T
V
K
V
I
G
K
G
A
F
G
E
V
R
L
V
Q
K
K
D
T
G
-
K
I
Y
A
M
K
T
L
L
K
S
--
E
MYK-----
K
---------------------
S
-
D
S
P
W
V
V
S
L
Y
Y
S
F
--
Q
--
D
A
Q
Y
L
Y
L
I
M
E
F
L
P
G
G
D
L
M
T
M
L
I
R
W
----
Q
L
F
T
E
D
V
T
R
F
Y
M
A
E
C
I
L
A
I
E
T
I
H
K
-
L
G
-----
F
I
H
R
A
I
K
P
D
N
I
L
I
--
D
--
I
--
R
---
G
----
H
I
K
L
S
D
F
G
L
S
T
G
F
H
K
T
H
D
S
N
YNRQQ
I
Q
T
W
R
KSRRL
M
A
Y
S
T
V
G
T
P
D
Y
I
A
P
E
I
F
L
------
Y
------
Q
G
----
Y
G
Q
E
C
D
W
W
S
L
G
A
I
M
Y
E
C
L
I
G
W
P
P
F
C
----
S
E
T
P
Q
E
T
Y
R
K
I
M
N
F
E
---
Q
T
L
Q
-
F
---
P
---
D
D
I
H
---
I
S
Y
E
A
E
D
L
I
R
R
L
L
T
H
A
D
Q
R
LGR
H
G
-----
G
A
D
E
I
K
S
H
P
F
F
R
G
V
------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
58.38
35%
-5
- C1 -
-
2W5A
5
NEK2_HUMAN
A:
[54-271]
--------------------------------------------------------------------------------------------------------------------------------
S
E
V
N
L
L
R
E
L
-
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
--
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
-
R
S
------
L
H
R
D
L
K
P
A
N
V
F
L
--
D
--
G
--
K
---
Q
----
N
V
K
L
G
D
F
G
L
A
R
I
L
---
T
S
F
-----------------
A
K
T
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
------
R
------
M
-----
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
----
A
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
---
F
----
R
---
R
---
I
P
Y
R
---
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
---
R
P
-----
S
V
E
E
I
L
E
N
P
L
I
---------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
57.16
35%
20
- C1 -
-
5M51
1
NEK2_HUMAN
A:
[54-271]
--------------------------------------------------------------------------------------------------------------------------------
S
E
V
N
L
L
R
E
L
-
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
--
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
-
R
S
DG
G
H
T
V
L
H
R
D
L
K
P
A
N
V
F
L
--
D
--
G
--
K
---
Q
----
N
V
K
L
G
D
F
---------------------------------
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
------
R
------
M
S
----
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
----
A
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
---
F
----
R
---
R
---
I
P
Y
R
---
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
---
R
P
-----
S
V
E
E
I
L
E
N
P
L
I
---------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
56.88
35%
0
- C1 -
-
2XNM
10
NEK2_HUMAN
A:
[54-271]
--------------------------------------------------------------------------------------------------------------------------------
S
E
V
N
L
L
R
E
L
-
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
--
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
-
R
---------
R
D
L
K
P
A
N
V
F
L
--
D
--
G
--
K
---
Q
----
N
V
K
L
G
D
F
G
L
A
R
I
L
--------------------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
------
R
-------
S
----
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
----
A
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
---
F
----
R
---
R
---
I
P
Y
R
---
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
---
R
P
-----
S
V
E
E
I
L
E
N
P
L
I
---------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
56.07
35%
13
- C1 -
-
5M57
1
NEK2_HUMAN
A:
[54-271]
--------------------------------------------------------------------------------------------------------------------------------
S
E
V
N
L
L
R
E
L
-
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
--
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
-
R
S
DGGHT
V
L
H
R
D
L
K
P
A
N
V
F
L
--
D
--
G
--
K
---
Q
----
N
V
K
L
G
D
F
---------------------------------
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
------
R
------
M
S
----
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
----
A
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
---
F
----
R
---
R
---
I
P
Y
R
---
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
---
R
P
-----
S
V
E
E
I
L
E
N
P
L
I
---------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
54.61
35%
-5
- C1 -
-
2XK4
1
NEK2_HUMAN
A:
[54-271]
--------------------------------------------------------------------------------------------------------------------------------
S
E
V
N
L
L
R
E
L
-
K
H
P
N
I
V
R
Y
Y
D
R
I
ID
R
--
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
-
R
S
--------
R
D
L
K
P
A
N
V
F
L
--
D
--
G
--
K
---
Q
----
N
V
K
L
G
D
F
G
L
------------------------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
------
R
------
M
------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
----
A
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
---
F
----
R
---
R
---
I
P
Y
R
---
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
---
R
P
-----
S
V
E
E
I
L
E
N
P
L
I
---------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
53.67
35%
-1
- C1 -
-
2XKF
1
NEK2_HUMAN
A:
[54-271]
--------------------------------------------------------------------------------------------------------------------------------
S
E
V
N
L
L
R
E
L
-
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
--
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
-
R
S
--------
R
D
L
K
P
A
N
V
F
L
--
D
--
G
--
K
---
Q
----
N
V
K
L
G
D
F
--------------------------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
------
R
-------
S
----
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
----
A
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
---
F
----
R
---
R
---
I
P
Y
R
---
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
---
R
P
-----
S
V
E
E
I
L
E
N
P
L
I
---------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
53.47
35%
-11
- C1 -
-
2XKD
1
NEK2_HUMAN
A:
[54-271]
--------------------------------------------------------------------------------------------------------------------------------
S
E
V
N
L
L
R
E
L
-
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
--
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
-
R
S
D---------
L
K
P
A
N
V
F
L
--
D
--
G
--
K
---
Q
----
N
V
K
L
G
D
F
-------------------------------
T
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
------
R
------
M
S
----
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
----
A
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
---
F
----
R
---
R
---
I
P
Y
R
---
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
---
R
P
-----
S
V
E
E
I
L
E
N
P
L
I
---------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
53.43
35%
-6
- C1 -
-
2XNO
13
NEK2_HUMAN
A:
[54-271]
--------------------------------------------------------------------------------------------------------------------------------
S
E
V
N
L
L
R
E
L
-
K
H
P
N
I
V
R
Y
Y
D
R
I
ID
R
--
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
-
R
S
--------
R
D
L
K
P
A
N
V
F
L
--
D
--
G
--
K
---
Q
----
N
V
K
L
G
D
F
--------------------------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
------
R
-------------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
----
A
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
---
F
----
R
---
R
---
I
P
Y
R
---
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
---
R
P
-----
S
V
E
E
I
L
E
N
P
L
I
---------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
52.95
35%
-6
- C1 -
-
2XNP
6
NEK2_HUMAN
A:
[54-271]
--------------------------------------------------------------------------------------------------------------------------------
S
E
V
N
L
L
R
E
L
-
K
H
P
N
I
V
R
Y
Y
D
R
I
ID
R
--
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
-
R
S
-------
H
R
D
L
K
P
A
N
V
F
L
--
D
--
G
--
K
---
Q
----
N
V
K
L
G
D
F
G
L
------------------------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
------
R
-------------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
----
A
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
---
F
----
R
---
R
---
I
P
Y
R
---
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
---
R
P
-----
S
V
E
E
I
L
E
N
P
L
I
---------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
51.83
35%
-4
- C1 -
-
2XK7
1
NEK2_HUMAN
A:
[54-271]
--------------------------------------------------------------------------------------------------------------------------------
S
E
V
N
L
L
R
E
L
-
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
--
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
-
R
S
--------
R
D
L
K
P
A
N
V
F
L
--
D
--
G
--
K
---
Q
----
N
V
K
L
G
D
F
---------------------------------
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
--------------------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
----
A
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
---
F
----
R
---
R
---
I
P
Y
R
---
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
---
R
P
-----
S
V
E
E
I
L
E
N
P
L
I
---------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
51.65
35%
3
- C1 -
-
2XK3
1
NEK2_HUMAN
A:
[54-271]
--------------------------------------------------------------------------------------------------------------------------------
S
E
V
N
L
L
R
E
L
-
K
H
P
N
I
V
R
Y
Y
D
R
I
ID
R
--
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
-
R
S
--------
R
D
L
K
P
A
N
V
F
L
--
D
--
G
--
K
---
Q
----
N
V
K
L
G
D
F
G
--------------------------------
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
------
R
-------------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
----
A
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
---
F
----
R
---
R
---
I
P
Y
R
---
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
---
R
P
-----
S
V
E
E
I
L
E
N
P
L
I
---------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
51.62
35%
1
- C1 -
-
2XNN
5
NEK2_HUMAN
A:
[54-271]
--------------------------------------------------------------------------------------------------------------------------------
S
E
V
N
L
L
R
E
L
-
K
H
P
N
I
V
R
Y
Y
D
R
I
ID
R
--
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
-
R
S
--------
R
D
L
K
P
A
N
V
F
L
--
D
--
G
--
K
---
Q
----
N
V
K
L
G
D
F
G
-------------------------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
------
R
------------
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
----
A
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
---
F
----
R
---
R
---
I
P
Y
R
---
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
---
R
P
-----
S
V
E
E
I
L
E
N
P
L
I
---------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
50.99
35%
-9
- C1 -
-
2XK8
1
NEK2_HUMAN
A:
[54-271]
--------------------------------------------------------------------------------------------------------------------------------
S
E
V
N
L
L
R
E
L
-
K
H
P
N
I
V
R
Y
Y
D
R
I
ID
R
--
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
-
R
S
--------
R
D
L
K
P
A
N
V
F
L
--
D
--
G
--
K
---
Q
----
N
V
K
L
G
D
F
--------------------------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
--------------------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
----
A
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
---
F
----
R
---
R
---
I
P
Y
R
---
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
---
R
P
-----
S
V
E
E
I
L
E
N
P
L
I
---------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
50.87
35%
4
- C1 -
-
2XK6
1
NEK2_HUMAN
A:
[54-271]
--------------------------------------------------------------------------------------------------------------------------------
S
E
V
N
L
L
R
E
L
-
K
H
P
N
I
V
R
Y
Y
D
R
I
ID
R
--
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
-
R
S
--------
R
D
L
K
P
A
N
V
F
L
--
D
--
G
--
K
---
Q
----
N
V
K
L
G
D
----------------------------------
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
------
R
-------------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
----
A
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
---
F
----
R
---
R
---
I
P
Y
R
---
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
---
R
P
-----
S
V
E
E
I
L
E
N
P
L
I
---------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
50.13
35%
0
- C1 -
-
2XKE
1
NEK2_HUMAN
A:
[54-271]
--------------------------------------------------------------------------------------------------------------------------------
S
E
V
N
L
L
R
E
L
-
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
--
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
-
R
S
D---------
L
K
P
A
N
V
F
L
--
D
--
G
--
K
---
Q
----
N
V
K
L
G
D
F
-----------------------------------
T
P
Y
Y
M
S
P
E
Q
M
N
--------------------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
----
A
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
---
F
----
R
---
R
---
I
P
Y
R
---
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
---
R
P
-----
S
V
E
E
I
L
E
N
P
L
I
---------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
47.41
35%
11
- C1 -
-
2XKC
1
NEK2_HUMAN
A:
[54-271]
--------------------------------------------------------------------------------------------------------------------------------
S
E
V
N
L
L
R
E
L
-
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
--
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
-
R
S
----------
L
K
P
A
N
V
F
L
--
D
--
G
--
K
---
Q
----
N
V
K
L
G
D
-----------------------------------
G
T
P
Y
Y
M
S
P
E
Q
M
N
------
R
-------------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
----
A
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
---
F
----
R
---
R
---
I
P
Y
R
---
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
---
R
P
-----
S
V
E
E
I
L
E
N
P
L
I
---------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
47.12
35%
7
- C1 -
-
2WQO
1
NEK2_HUMAN
A:
[54-271]
--------------------------------------------------------------------------------------------------------------------------------
S
E
V
N
L
L
R
E
L
-
K
H
P
N
I
V
R
Y
Y
D
R
I
ID
R
--
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
-
R
-----------
L
K
P
A
N
V
F
L
--
D
--
G
--
K
---
Q
----
N
V
K
L
G
D
-----------------------------------
G
T
P
Y
Y
M
S
P
E
Q
M
N
------
R
-------------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
----
A
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
---
F
----
R
---
R
---
I
P
Y
R
---
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
---
R
P
-----
S
V
E
E
I
L
E
N
P
L
I
---------------------------------------------------------------------------------------------------------------------------------------------------------