@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_35_5330: (2018-03-13 )
MQKYQILGKKGEGTFSEVLRAQDIKTQQYVAIKCMKKAFKSKEQVNRLREIQAVRRLQPHPNIVDLVEVLFDRSTGRLALVLELMDMSLYELIKGRKQYLGEEKVRSYMYQLLKGLDHAHRIGVFHRDIKPENLLIDAEGHLKIADFGSCKGVYSKLPLTEYISTRWYRAPECLLTDGYYNYKMDLWSAGCVFFEIIALFPLFPGSNELDQVHRIHNVLGTPPTEILDRLKKFGTHMDYDFPKKQGTGLAKLLPHVSADALDLMKKLLTYDEEQRCTAKEALRHAYFSKLREADKKSHRPKHSASISRPTTVTDDAHASMGLGSSPRKTTNGMPSLNGTLTASRKLPVIDGKSPTKSSTLVSNQSTLHQVHGAVATSASGEDLVARSLPKLI
Atome Classification :
(20 SA)
.........10........20........30........40.-..---.--....50........60........70..----.----.....80........90....---....-100.......110.......120.......130.......-140.......150.....-----..160---.......170.......180.......190.....-..200.......210.......220.......230...-....--240.......-.250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MQ
K
Y
Q
I
LGKKGE
G
T
F
S
E
V
L
R
AQDIKT
Q
Q
Y
V
A
I
K
C
M
K
K
A
FK
S
K
-
E
Q
---
V
--
N
R
L
R
E
I
Q
A
V
R
RLQPHP
N
I
V
D
L
V
E
V
L
FDR----S----T
G
R
L
A
L
V
L
E
L
M
D
M
S
L
Y
E
L
I
K
G
---
R
K
Q
Y-L
G
E
E
K
V
R
S
Y
M
Y
Q
L
L
K
GL
D
H
A
H
R
IG
V
F
HRDIKPE
N
L
L
IDAE-G
H
L
K
I
ADFGSC
K
G
V
Y
S
KL-----
P
L
T
E
Y
---
I
S
T
R
WYRAPE
C
L
L
TDG
Y
Y
N
Y
K
M
DLWS
A
G
C
V
F
F
E
I
I
-
A
L
FPLFPGS
N
E
L
D
Q
V
H
R
I
H
N
V
LGT
P
P
T
E
I
L
D
R
L
K
K
FGT-HMDY--D-FPKKQGT
G
-
L
A
K
L
L
P
HVS
A
D
A
L
D
L
M
K
K
L
LT
Y
D
E
E
QRC
T
A
K
E
A
L
R
H
A
Y
F
S
K
L
R
E
A
D
K
KSHRPKHSASISRPTTVTDDAHASMGLGSSPRKTTNGMPSLN
G
T
L
TASRKLPVIDGKSPTKSSTLVSN
Q
S
T
L
H
Q
V
H
G
AVATSASG
E
D
L
V
A
R
SLPKLI
7
PsiBlast_PDB
84.81
35%
-133
- C1 -
-
2QKR
-
?
A:
[20-307]
M
E
K
Y
--
L
E
K
V
G
E
G
---
V
V
Y
K
A
K
D
S
Q
-
R
-
I
V
A
L
K
R
I
-------------
S
--
T
A
I
R
E
I
S
L
L
K
E
L
H
-
H
P
N
I
V
S
L
I
D
V
I
--
H
----
S
----
E
-
C
L
T
L
V
F
E
F
M
E
K
D
L
K
K
V
L
D
E
---
N
K
T
G
-
L
Q
D
S
Q
I
K
I
Y
L
Y
Q
L
L
R
G
V
A
H
C
H
Q
H
R
I
L
H
R
D
L
K
P
Q
N
L
L
I
N
S
D
--
A
L
K
L
A
D
F
G
L
A
R
A
F
--
G
I
-----
P
V
R
-----
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
S
V
D
I
W
S
I
G
C
I
F
A
E
M
I
-
T
G
K
P
L
F
P
G
V
T
D
D
D
Q
L
P
K
I
F
S
I
L
G
T
P
N
P
R
E
W
P
Q
V
Q
E
L
P
L
-
W
K
Q
R
--
T
-
F
Q
V
F
E
K
K
P
-
W
S
S
I
I
P
G
F
C
Q
E
G
I
D
L
L
S
N
M
L
C
F
D
P
N
K
R
I
S
A
R
D
A
M
N
H
P
Y
F
K
D
L
------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
81.98
33%
-112
- C1 -
-
3MTL
-
CDK16_HUMAN
A:
[1-301]
M
E
T
Y
I
K
L
D
K
L
G
E
G
T
Y
A
T
V
Y
K
G
K
S
K
L
T
D
N
L
V
A
L
K
E
I
R
L
-------
P
---
C
--
T
A
I
R
E
V
S
L
L
K
D
L
K
-
H
A
N
I
V
T
L
H
D
I
I
H
T
E
----
K
----
S
--
L
T
L
V
F
E
Y
L
D
K
D
L
K
Q
Y
L
D
D
---
C
G
N
I
-
I
N
M
H
N
V
K
L
F
L
F
Q
L
L
R
G
L
A
Y
C
H
R
Q
K
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
E
R
-
G
E
L
K
L
A
D
F
G
L
A
R
A
--
K
-----------------
T
L
W
Y
R
P
P
D
I
L
L
G
S
T
D
Y
S
T
Q
I
D
M
W
G
V
G
C
I
F
Y
E
M
A
-
T
G
R
P
L
F
P
G
S
T
V
E
E
Q
L
H
F
I
F
R
I
L
G
T
P
T
E
E
T
W
P
G
I
L
S
N
E
E
-
F
K
T
Y
--
N
-
Y
P
K
Y
R
A
E
A
-
L
L
S
H
A
P
R
L
D
S
D
G
A
D
L
L
T
K
L
L
Q
F
E
G
R
N
R
I
S
A
E
D
A
M
K
H
P
F
F
L
S
L
G
E
---
R
I
H
K
L
P
D
T
T
S
I
--------------------------------------------------------------------------------------
4
PsiBlast_PDB
81.77
37%
-10
- C1 -
-
4YC3
1
CDK1_HUMAN
A:
[6-301]
M
E
D
Y
T
K
I
E
K
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
K
T
T
G
Q
V
V
A
M
K
K
I
R
--
L
E
S
E
-
E
E
GVP
S
--
T
A
I
R
E
I
S
L
L
K
E
L
R
-
H
P
N
I
V
S
L
Q
D
V
L
M
Q
D
----
S
------
R
L
Y
L
I
F
E
F
L
S
M
D
L
K
K
Y
L
D
S
IP-
P
G
Q
Y
-
M
D
S
S
L
V
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
D
D
K
-
G
T
I
K
L
A
D
F
G
L
A
R
A
F
--
G
I
-----
P
I
R
V
Y
T---
V
T
L
W
Y
R
S
P
E
V
L
L
G
S
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
-
T
K
K
P
L
F
H
G
D
S
E
I
D
Q
L
F
R
I
F
R
A
L
G
T
P
N
N
E
V
W
P
E
V
E
S
L
Q
D
-
Y
K
N
---
T
-
F
P
K
W
K
P
G
S
-
L
A
S
H
V
K
N
L
D
E
N
G
L
D
L
L
S
K
M
L
I
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
N
D
L
D
N
Q
I
K
K
------------------------------------------------------------------------------------------------
25
HHSearch
81.02
34%
-114
- C1 -
-
5G6V
3
CDK16_HUMAN
B:
[1-290]
M
E
T
Y
I
K
L
D
K
L
G
E
G
T
Y
A
T
V
Y
K
G
K
S
K
L
T
D
N
L
V
A
L
K
E
I
R
L
E
H
E
E
G
-
A
P
---
C
--
T
A
I
R
E
V
S
L
L
K
D
L
K
-
H
A
N
I
V
T
L
H
D
I
I
H
T
----------
E
K
S
L
T
L
V
F
E
Y
L
D
K
D
L
K
Q
Y
L
D
D
---
C
G
N
I
-
I
N
M
H
N
V
K
L
F
L
F
Q
L
L
R
G
L
A
Y
C
H
R
Q
K
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
E
R
-
G
E
L
K
L
A
D
F
G
L
A
R
A
-------------------
V
T
L
W
Y
R
P
P
D
I
L
L
G
S
T
D
Y
S
T
Q
I
D
M
W
G
V
G
C
I
F
Y
E
M
A
-
T
G
R
P
L
F
P
G
S
T
V
E
E
Q
L
H
F
I
F
R
I
L
G
T
P
T
E
E
T
W
P
G
I
L
S
N
E
E
-
F
K
T
Y
--
N
-
Y
P
K
Y
R
A
E
A
-
L
L
S
H
A
P
R
L
D
S
D
G
A
D
L
L
T
K
L
L
Q
F
E
G
R
N
R
I
S
A
E
D
A
M
K
H
P
F
F
L
S
L
G
E
----------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
79.99
37%
-6
- C1 -
-
5HQ0
1
CDK1_HUMAN
A:
[6-294]
M
E
D
Y
T
K
I
E
K
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
K
T
T
G
Q
V
V
A
M
K
K
I
R
--
L
E
S
E
-
E
E
GVP
S
--
T
A
I
R
E
I
S
L
L
K
E
L
R
-
H
P
N
I
V
S
L
Q
D
V
L
M
Q
D
----
S
------
R
L
Y
L
I
F
E
F
L
S
M
D
L
K
K
Y
L
D
S
IP-
P
G
Q
Y
-
M
D
S
S
L
V
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
D
D
K
-
G
T
I
K
L
A
D
F
G
L
A
R
A
F
--
G
I
-----
P
I
R
V
Y
T
HE
V
V
T
L
W
Y
R
S
P
E
V
L
L
G
S
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
-
T
K
K
P
L
F
H
G
D
S
E
I
D
Q
L
F
R
I
F
R
A
L
G
T
P
N
N
E
V
W
P
E
V
E
S
L
Q
D
-
Y
K
N
---
T
-
F
P
K
W
K
P
G
S
-
L
A
S
H
V
K
N
L
D
E
N
G
L
D
L
L
S
K
M
L
I
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
N
D
-------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
79.99
37%
-6
- C1 -
-
4Y72
1
CDK1_HUMAN
A:
[6-294]
M
E
D
Y
T
K
I
E
K
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
K
T
T
G
Q
V
V
A
M
K
K
I
R
--
L
E
S
E
-
E
E
GVP
S
--
T
A
I
R
E
I
S
L
L
K
E
L
R
-
H
P
N
I
V
S
L
Q
D
V
L
M
Q
D
----
S
------
R
L
Y
L
I
F
E
F
L
S
M
D
L
K
K
Y
L
D
S
IP-
P
G
Q
Y
-
M
D
S
S
L
V
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
D
D
K
-
G
T
I
K
L
A
D
F
G
L
A
R
A
F
--
G
I
-----
P
I
R
V
Y
T
HE
V
V
T
L
W
Y
R
S
P
E
V
L
L
G
S
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
-
T
K
K
P
L
F
H
G
D
S
E
I
D
Q
L
F
R
I
F
R
A
L
G
T
P
N
N
E
V
W
P
E
V
E
S
L
Q
D
-
Y
K
N
---
T
-
F
P
K
W
K
P
G
S
-
L
A
S
H
V
K
N
L
D
E
N
G
L
D
L
L
S
K
M
L
I
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
N
D
-------------------------------------------------------------------------------------------------------
39
HHSearch
79.88
36%
-85
- C1 -
-
1UA2
1
CDK7_HUMAN
D:
[13-298]
----
E
K
L
D
F
L
G
E
G
Q
F
A
T
V
Y
K
A
R
D
K
N
T
N
Q
I
V
A
I
K
K
I
---------
N
---
R
--
T
A
L
R
E
I
K
L
L
Q
E
L
S
-
H
P
N
I
I
G
L
L
D
A
F
G
H
----------
K
S
N
I
S
L
V
F
D
F
M
E
T
D
L
E
V
I
I
K
D
---
N
S
L
V
-
L
T
P
S
H
I
K
A
Y
M
L
M
T
L
Q
G
L
E
Y
L
H
Q
H
W
I
L
H
R
D
L
K
P
N
N
L
L
L
D
E
N
-
G
V
L
K
L
A
D
F
G
L
A
K
S
F
G
S
P
N
R----
A
Y
T
H
Q
---
V
V
T
R
W
Y
R
A
P
E
L
L
F
G
A
R
M
Y
G
V
G
V
D
M
W
A
V
G
C
I
L
A
E
L
L
-
L
R
V
P
F
L
P
G
D
S
D
L
D
Q
L
T
R
I
F
E
T
L
G
T
P
T
E
E
Q
W
P
D
M
C
S
L
P
D
-
Y
V
T
-----
F
K
S
F
P
G
I
P
-
L
H
H
I
F
S
A
A
G
D
D
L
L
D
L
I
Q
G
L
F
L
F
N
P
C
A
R
I
T
A
T
Q
A
L
K
M
K
Y
F
S
N
R
------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
79.09
36%
-15
- C1 -
-
4EOM
1
CDK2_HUMAN
A:
[5-290]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
--
E
T
E
G
V
P
---
S
--
T
A
I
R
E
I
S
L
L
K
E
L
N
-
H
P
N
I
V
K
L
L
D
V
I
--
H
----
T
----
E
N
K
L
Y
L
V
F
E
F
L
S
M
D
L
K
K
F
M
D
A
---
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
-----
P
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
----
D
Y
KP
S
-
F
P
K
W
A
R
Q
D
-
F
S
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
---------------------------------------------------------------------------------------------------------
28
HHSearch
78.62
36%
-20
- C1 -
-
5BYZ
7
MK07_HUMAN
A:
[6-306]
-
D
E
Y
E
I
I
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
R
R
L
T
G
Q
Q
V
A
I
K
K
I
P
N
A
F
D
V
V
T
N
A
---
K
--
R
T
L
R
E
L
K
I
L
K
H
F
K
-
H
D
N
I
I
A
I
K
D
I
L
R
P
T
VPYG
E
----
F
K
S
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
H
S
---
S
-
Q
P
-
L
T
L
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
E
N
-
C
E
L
K
I
G
D
F
G
M
A
R
G
L
C
T
S
P
AEHQY
F
M
T
E
Y
---
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
H
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
-
A
R
R
Q
L
F
P
G
K
N
Y
V
H
Q
L
Q
L
I
M
M
V
L
G
T
P
S
P
A
V
I
Q
A
V
G
A
E
R
V
R
A
Y
I
Q
--
S
-
L
P
P
R
Q
P
V
P
-
W
E
T
V
Y
P
G
A
D
R
Q
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
Y
H
D
P
---------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
78.45
36%
-12
- C1 -
-
4EON
1
CDK2_HUMAN
A:
[3-288]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
---
S
--
T
A
I
R
E
I
S
L
L
K
E
L
N
-
H
P
N
I
V
K
L
L
D
V
I
--
H
----
T
----
E
N
K
L
Y
L
V
F
E
F
L
S
M
D
L
K
K
F
M
D
A
---
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
E
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
-----
P
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
----
D
Y
KP
S
-
F
P
K
W
A
R
Q
D
-
F
S
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
---------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
78.40
39%
-2
- C1 -
-
3O0G
-
CDK5_HUMAN
A:
[1-287]
M
Q
K
Y
E
K
L
E
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
R
E
T
H
E
I
V
A
L
K
R
V
R
L
D
-
D
D
D
-
E
G
---
V
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
-
H
K
N
I
V
R
L
H
D
V
L
--
H
----
S
----
D
K
K
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
S
---
C
N
G
D
-
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
R
N
-
G
E
L
K
L
A
N
F
G
L
A
R
A
F
--
G
I
-----
P
V
R
C
Y
SAE
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
R
P
L
F
P
G
N
D
V
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
T
K
L
P
D
-
Y
K
P
Y
--
P
M
Y
P
A
T
--
T
S
-
L
V
N
V
V
P
K
L
N
A
T
G
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
S
--------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
78.11
36%
-14
- C1 -
-
4EOL
1
CDK2_HUMAN
A:
[4-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
--
E
T
E
G
V
P
---
S
--
T
A
I
R
E
I
S
L
L
K
E
L
N
-
H
P
N
I
V
K
L
L
D
V
I
--
H
----
T
----
E
N
K
L
Y
L
V
F
E
F
L
S
M
D
L
K
D
F
M
D
A
---
S
-
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
-----
P
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
----
D
Y
KP
S
-
F
P
K
W
A
R
Q
D
-
F
S
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
---------------------------------------------------------------------------------------------------------
26
HHSearch
77.95
34%
-102
- C1 -
-
5G6V
4
CDK16_HUMAN
A:
[1-290]
M
E
T
Y
I
K
L
D
K
L
G
E
G
T
Y
A
T
V
Y
K
G
K
S
K
L
T
D
N
L
V
A
L
K
E
I
R
L
E
H
E
E
G
-
A
P
---
C
--
T
A
I
R
E
V
S
L
L
K
D
L
K
-
H
A
N
I
V
T
L
H
D
I
I
H
T
----------
E
K
S
L
T
L
V
F
E
Y
L
D
K
D
L
K
Q
Y
L
D
D
---
C
G
N
I
-
I
N
M
H
N
V
K
L
F
L
F
Q
L
L
R
G
L
A
Y
C
H
R
Q
K
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
E
R
-
G
E
L
K
L
A
D
F
G
L
A
R
A
K
---------
T
Y
D
N
E
---
V
V
T
L
W
Y
R
P
P
D
I
L
L
G
S
T
D
Y
S
T
Q
I
D
M
W
G
V
G
C
I
F
Y
E
M
A
-
T
G
R
P
L
F
P
G
S
T
V
E
E
Q
L
H
F
I
F
R
I
L
G
T
P
T
E
E
T
W
P
G
I
L
S
N
E
E
-
F
K
T
Y
--
N
-
Y
P
K
Y
R
A
E
A
-
L
L
S
H
A
P
R
L
D
S
D
G
A
D
L
L
T
K
L
L
Q
F
E
G
R
N
R
I
S
A
E
D
A
M
K
H
P
F
F
L
S
L
G
E
----------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
77.78
36%
-16
- C1 -
-
4EOJ
1
CDK2_HUMAN
A:
[5-290]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----
E
G
V
P
---
S
--
T
A
I
R
E
I
S
L
L
K
E
L
N
-
H
P
N
I
V
K
L
L
D
V
I
--
H
----
T
----
E
N
K
L
Y
L
V
F
E
F
L
S
M
D
L
K
D
F
M
D
A
---
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
-----
P
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
----
D
Y
KP
S
-
F
P
K
W
A
R
Q
D
-
F
S
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
---------------------------------------------------------------------------------------------------------
21
HHSearch
77.30
36%
-28
- C1 -
-
1J1B
1
GSK3B_HUMAN
B:
[55-345]
--
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
C
D
S
G
E
L
V
A
I
K
K
V
L
Q
D
K
---------
R
--
F
K
N
R
E
L
Q
I
M
R
K
L
D
-
H
C
N
I
V
R
L
R
Y
F
F
Y
S
S
----
G
EKKD
E
V
Y
L
N
L
V
L
D
Y
V
P
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
-
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
H
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
D
P
D
T
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
-----
P
N
V
S
Y
---
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
-
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
N
Y
T
---
E
F
--
K
-
F
P
Q
I
K
A
H
P
W
T
K
V
F
R
P
R
T
P
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
----------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
77.01
39%
-2
- C1 -
-
1UNL
1
CDK5_HUMAN
A:
[1-287]
M
Q
K
Y
E
K
L
E
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
R
E
T
H
E
I
V
A
L
K
R
V
R
L
D
-
D
D
D
-
E
G
---
V
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
-
H
K
N
I
V
R
L
H
D
V
L
--
H
----
S
----
D
K
K
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
S
---
C
N
G
D
-
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
R
N
-
G
E
L
K
L
A
N
F
G
L
A
R
A
F
--
G
I
-----
P
V
R
C
Y
SAE
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
G
R
P
L
F
P
G
N
D
V
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
T
K
L
P
D
-
Y
K
P
Y
--
P
M
Y
P
A
T
--
T
S
-
L
V
N
V
V
P
K
L
N
A
T
G
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
S
--------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
76.85
37%
2
- C1 -
-
5LQF
1
CDK1_HUMAN
A:
[6-294]
M
E
D
Y
T
K
I
E
K
I
G
E
G
T
Y
G
V
V
Y
K
G
R
H
K
T
T
G
Q
V
V
A
M
K
K
I
R
--
L
E
S
E
-
E
E
GVP
S
--
T
A
I
R
E
I
S
L
L
K
E
L
R
-
H
P
N
I
V
S
L
Q
D
V
L
M
Q
D
----
S
------
R
L
Y
L
I
F
E
F
L
S
M
D
L
K
K
Y
L
D
S
IP-
P
G
Q
Y
-
M
D
S
S
L
V
K
S
Y
L
Y
Q
I
L
Q
G
I
V
F
C
H
S
R
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
D
D
K
-
G
T
I
K
L
A
D
F
G
L
A
R
A
F
--
G
I
-----
P
I
R
-----
V
V
T
L
W
Y
R
S
P
E
V
L
L
G
S
A
R
Y
S
T
P
V
D
I
W
S
I
G
T
I
F
A
E
L
A
-
T
K
K
P
L
F
H
G
D
S
E
I
D
Q
L
F
R
I
F
R
A
L
G
T
P
N
N
E
V
W
P
E
V
E
S
L
Q
D
-
Y
K
N
---
T
-
F
P
K
W
K
P
G
S
-
L
A
S
H
V
K
N
L
D
E
N
G
L
D
L
L
S
K
M
L
I
Y
D
P
A
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
N
D
-------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
76.61
36%
-16
- C1 -
-
4EOK
1
CDK2_HUMAN
A:
[4-289]
M
E
N
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
----
E
G
V
P
---
S
--
T
A
I
R
E
I
S
L
L
K
E
L
N
-
H
P
N
I
V
K
L
L
D
V
I
--
H
----
T
----
E
N
K
L
Y
L
V
F
E
F
L
S
M
D
L
K
D
F
M
D
A
---
S
A
L
T
G
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
-
G
A
I
K
L
A
D
F
G
L
A
R
A
F
--
G
V
-----
P
V
R
T
Y
THE
V
V
T
L
W
Y
R
A
P
E
I
L
L
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
-
T
R
R
A
L
F
P
G
D
S
E
I
D
Q
L
F
R
I
F
R
T
L
G
T
P
D
E
V
V
W
P
G
V
T
S
M
P
----
D
Y
KP
S
-
F
P
K
W
A
R
Q
D
-
F
S
K
V
V
P
P
L
D
E
D
G
R
S
L
L
S
Q
M
L
H
Y
D
P
N
K
R
I
S
A
K
A
A
L
A
H
P
F
F
---------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
76.05
35%
-51
- C1 -
-
3NIZ
1
?
A:
[20-307]
M
E
K
Y
Q
K
L
E
K
V
G
E
G
T
Y
G
V
V
Y
K
A
K
D
S
Q
G
R
-
I
V
A
L
K
R
I
R
-----
G
-
I
P
---
S
--
T
A
I
R
E
I
S
L
L
K
E
L
H
-
H
P
N
I
V
S
L
I
D
V
I
--
H
----
S
----
E
R
C
L
T
L
V
F
E
F
M
E
K
D
L
K
K
V
L
D
E
---
N
K
T
G
-
L
Q
D
S
Q
I
K
I
Y
L
Y
Q
L
L
R
G
V
A
H
C
H
Q
H
R
I
L
H
R
D
L
K
P
Q
N
L
L
I
N
S
D
-
G
A
L
K
L
A
D
F
G
L
A
R
A
F
--
G
I
-----
P
V
R
--H
E
-
V
V
T
L
W
Y
R
A
P
D
V
L
M
G
S
K
K
Y
S
T
S
V
D
I
W
S
I
G
C
I
F
A
E
M
I
-
T
G
K
P
L
F
P
G
V
T
D
D
D
Q
L
P
K
I
F
S
I
L
G
T
P
N
P
R
E
W
P
Q
V
Q
E
L
P
L
-
W
K
Q
R
--
T
-
F
Q
V
F
E
K
K
P
-
W
S
S
I
I
P
G
F
C
Q
E
G
I
D
L
L
S
N
M
L
C
F
D
P
N
K
R
I
S
A
R
D
A
M
N
H
P
Y
F
K
D
L
------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
75.86
40%
-6
- C1 -
-
1H4L
-
CDK5_HUMAN
A:
[2-287]
-
Q
K
Y
E
K
L
E
K
I
----
Y
G
T
V
F
K
A
K
N
R
E
T
H
E
I
V
A
L
K
R
V
R
L
D
------
G
---
V
P
S
S
A
L
R
E
I
C
L
L
K
E
L
K
-
H
K
N
I
V
R
L
H
D
V
L
--
H
----
S
----
D
K
K
L
T
L
V
F
E
F
C
D
Q
D
L
K
K
Y
F
D
S
---
C
N
G
D
-
L
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
R
N
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
R
N
-
G
E
L
K
L
A
D
F
G
L
A
R
A
F
--
G
I
-----
P
V
R
C
Y
SAE
V
V
T
L
W
Y
R
P
P
D
V
L
F
G
A
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
L
A
N
A
A
R
P
L
F
P
G
N
D
V
D
D
Q
L
K
R
I
F
R
L
L
G
T
P
T
E
E
Q
W
P
S
M
T
K
L
P
D
-
Y
K
P
Y
--
P
M
Y
P
A
T
--
T
S
-
L
V
N
V
V
P
K
L
N
A
T
G
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
P
Y
F
S
--------------------------------------------------------------------------------------------------------