@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_36_0920: (2018-03-13 )
MSRLKINLDAIERDGASATEGFCADGVRIGSLLVSSEGVRDNQGNSCVLSLSDLEVVPETEGGFLGKGSSGSVRRAVHRGSNKVVALKEIKVTGQTHINEIRRELETLHAGDFATPYLVGFYGAFAHEGSVFIAMEAMDGSLHELYKPVPPPVLASITRQMLKGLTYLHRTRHLIHRDLKPSNVLYNSRTGDIKISDFGVSSNLECTKADAHSFVGTVTYMSPERLRGEYYSYGADIWSLGLVVAELAVGVCPYAGLRGGSSEARFWALLQHLNGDGAALELPPEMDSDLADFISACVVKSPDRRPTCTELLRHPFILRHTAAAPEAEAQPFSTTTSTAPAPGGLFSPLNRASPVAGSAVPLASEGSILKATSPSRAAAAPLPLPSPLERHDGETDADVADRTVVAGWIHAVMARKVLHRARGHGSEDPHLEPLAAVSASTATGLGERGGAAGVSAVSSEDPQVAQLREFRAERNLERHSGDGGSAPVEQDCIAGVRSLTCDDLRRTSTGEPSVNLDDELNRLLF
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90.......-.100.......110.......120.......130.......140.......---.150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.....--..280-----------..--------......-----.290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520...
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
S
R
L
K
I
N
L
D
A
IERDGASATEGFCADG
V
R
I
G
S
L
L
VSSEGVRDNQG
N
S
C
V
L
S
LSD
L
E
V
VPETEGGFLGKGSS
G
S
V
R
R
A
V
HRGS
N
K
V
V
A
L
K
E
I
K
VT
G
Q
T
H
I
-
N
E
I
R
R
E
L
E
T
LHAGDFA
T
P
Y
L
V
G
F
Y
G
AFAHE
G
S
V
F
I
A
M
EAMDG-
S
L
H
E
L
YKP---VP
P
P
V
L
A
S
I
T
R
Q
M
L
K
G
L
T
Y
L
H
R
T
R
H
L
I
HRDLKPS
N
V
L
Y
NSRTG
D
I
K
I
S
DFGVSSN
L
E
CTKADA
H
S
F
V
G
T
V
TYM
S
P
E
R
LRG
E
Y
Y
SY
G
A
D
I
W
S
L
G
L
V
V
A
E
L
A
V
GVCPYAGLRGGS
S
E
A
R
F
W
A
L
L
Q
HLNGDG--
A
A
L
-------------EL--------PPEMD
S
-----
D
L
A
D
F
I
S
A
C
V
VKSPDRR
P
T
C
T
E
L
L
RH
P
F
I
L
RHTAAAPEAEAQPFSTTTSTAPAPGGLFSPLNRASPVAGSAVPLASEG
S
I
L
KATSPSRAAAAPLPLPS
P
L
E
RHDGETDADVAD
R
T
V
V
A
G
W
I
H
A
V
M
A
R
K
V
L
H
R
ARGHGSEDPHLE
P
L
A
A
VSASTATGLGERGGAAGVSAVSSED
P
Q
V
A
Q
L
R
E
F
R
A
ERN
L
E
RHSGDGGSAP
V
E
Q
D
C
I
A
G
V
R
SL
T
C
D
D
L
RRTSTGEPSVN
L
D
D
E
L
N
R
LLF
18
PsiBlast_PDB
86.55
37%
-29
- C1 -
-
3EQI
1
MP2K1_HUMAN
A:
[34-349]
----------------------------------------------------
D
F
E
K
I
S
E
-----
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
L
H
E
C
N
--
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
K
K
A
GR
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
-
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
--
I
D
S
M
A
N
S
F
V
G
T
R
S
Y
M
S
P
E
R
L
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
G
C
---------PM
A
I
F
-------------
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
GVFS
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
85.49
37%
-29
- C1 -
-
3EQG
2
MP2K1_HUMAN
A:
[34-348]
----------------------------------------------------
D
F
E
K
I
S
E
-----
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
L
H
E
C
N
--
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
K
K
A
GR
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
-
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
--
I
D
S
M
A
N
S
F
V
G
T
R
S
Y
M
S
P
E
R
L
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
G
C
---------PM
A
I
F
-------------
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
GVFS
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
84.94
37%
-26
- C1 -
-
3EQD
1
MP2K1_HUMAN
A:
[34-349]
----------------------------------------------------
D
F
E
K
I
S
E
-----
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
L
H
E
C
N
--
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
K
K
A
GR
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
-
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
--
I
D
S
M
A
N
S
F
V
G
T
R
S
Y
M
S
P
E
R
L
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
G
C
---------PM
A
I
F
-------------
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
GVFS
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
84.55
37%
-23
- C1 -
-
3EQC
2
MP2K1_HUMAN
A:
[34-349]
----------------------------------------------------
D
F
E
K
I
S
E
-----
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
L
H
E
C
N
--
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
K
K
A
GR
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
-
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
--
I
D
S
M
A
---
V
G
T
R
S
Y
M
S
P
E
R
L
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
G
C
---------PM
A
I
F
-------------
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
GVFS
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
84.27
37%
-28
- C1 -
-
3EQH
2
MP2K1_HUMAN
A:
[34-348]
----------------------------------------------------
D
F
E
K
I
S
E
-----
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
L
H
E
C
N
--
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
K
K
A
GR
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
-
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
--
I
D
S
M
A
N
S
F
V
G
T
R
S
Y
M
S
P
E
R
L
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
G
C
---------PM
A
I
F
-------------
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
GVFS
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
83.69
38%
-29
- C1 -
-
3ZLY
1
MP2K1_HUMAN
A:
[28-331]
------------------------------------------------
L
K
D
D
D
F
E
K
I
S
E
-----
L
G
A
G
-
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
L
H
E
C
N
--
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
K
K
A
GR
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
-
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
--
I
D
S
M
A
---
V
G
T
R
S
Y
M
S
P
E
R
L
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
G
C
---------PM
A
I
F
-------------
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
GVFS
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
82.23
39%
-14
- C1 -
-
4ANB
2
MP2K1_HUMAN
A:
[10-282]
----------------------------------------------------
D
F
E
K
I
S
E
-----
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
L
H
E
C
N
--
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
K
K
A
GR
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
-
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
--
I
D
E
M
A
N
E
F
V
G
T
R
S
Y
M
S
P
E
R
L
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
R
P
P
M
----------
A
I
F
E
L
L
--
D
Y
--
I
V
N
-------------
E
P
--------
P
P
K
L
P
S
AVFS
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
81.73
37%
-24
- C1 -
-
3EQF
1
MP2K1_HUMAN
A:
[34-348]
----------------------------------------------------
D
F
E
K
I
S
E
-----
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
L
H
E
C
N
--
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
K
K
A
GR
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
-
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
--
I
D
S
M
A
N
S
F
V
G
T
R
S
Y
M
S
P
E
R
L
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
G
C
---------PM
A
I
F
-------------
E
L
L
D
Y
I
V
N
EP
P
P
K
L
P
S
GVFS
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
81.28
38%
-24
- C1 -
-
3ZLX
1
MP2K1_HUMAN
A:
[32-331]
----------------------------------------------------
D
F
E
K
I
S
E
-----
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
L
H
E
C
N
--
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
K
K
A
GR
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
-
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
--
I
D
S
M
A
---
V
G
T
R
S
Y
M
S
P
E
R
L
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
G
C
---------PM
A
I
F
-------------
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
GVFS
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
80.84
40%
-14
- C1 -
-
3ORN
3
MP2K1_HUMAN
A:
[14-288]
----------------------------------------------------------------
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
L
H
E
C
N
--
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
K
K
A
GR
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
-
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
--
I
D
S
M
A
N
S
F
V
G
T
R
S
Y
M
S
P
E
R
L
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
--------
P
M
A
I
F
E
L
L
--
D
Y
--
I
V
N
-------------
E
P
--------
P
P
K
L
P
S
GVFS
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
80.71
38%
-28
- C1 -
-
5BX0
1
MP2K1_HUMAN
A:
[32-331]
----------------------------------------------------
D
F
E
K
I
S
E
-----
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
L
H
E
C
N
--
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
K
K
A
GR
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
-
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
--
I
D
S
M
A
N
S
F
V
G
T
R
S
Y
M
S
P
E
R
L
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
G
C
---------PM
A
I
F
-------------
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
GVFS
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
79.96
38%
-22
- C1 -
-
3ZLS
1
MP2K1_HUMAN
A:
[32-331]
----------------------------------------------------
D
F
E
K
I
S
E
-----
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
L
H
E
C
N
--
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
K
K
A
GR
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
-
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
--
I
D
S
M
A
N
S
F
V
G
T
R
S
Y
M
S
P
E
R
L
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
G
C
---------PM
A
I
F
-------------
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
GVFS
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
79.81
39%
-10
- C1 -
-
4AN3
2
MP2K1_HUMAN
A:
[10-282]
----------------------------------------------------
D
F
E
K
I
S
E
-----
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
L
H
E
C
N
--
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
K
K
A
GR
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
-
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
--
I
D
E
M
A
N
E
--
G
T
R
S
Y
M
S
P
E
R
L
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
R
P
P
M
----------
A
I
F
E
L
L
--
D
Y
--
I
V
N
-------------
E
P
--------
P
P
K
L
P
S
AVFS
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
78.84
39%
-13
- C1 -
-
4AN2
2
MP2K1_HUMAN
A:
[10-282]
----------------------------------------------------
D
F
E
K
I
S
E
-----
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
L
H
E
C
N
--
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
K
K
A
GR
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
-
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
--
I
D
E
M
A
N
E
F
V
G
T
R
S
Y
M
S
P
E
R
L
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
R
P
P
M
----------
A
I
F
E
L
L
--
D
Y
--
I
V
N
-------------
E
P
--------
P
P
K
L
P
S
AVFS
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
78.10
41%
-13
- C1 -
-
3SLS
2
MP2K1_HUMAN
A:
[26-287]
----------------------------------------------------
D
F
E
K
I
S
E
-----
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
L
H
E
C
N
--
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
K
K
A
GR
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
-
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
--
I
------
F
V
G
T
R
S
Y
M
S
P
E
R
L
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
---
I
G
------
A
I
F
E
L
L
D
Y
I
V
N
--------------------
E
P
--------
P
P
K
L
P
S
GVFS
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
77.66
38%
-15
- C1 -
-
3ZM4
1
MP2K1_HUMAN
A:
[32-331]
----------------------------------------------------
D
F
E
K
I
S
E
-----
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
L
H
E
C
N
--
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
K
K
A
GR
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
-
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
--
I
D
S
M
A
----
G
T
R
S
Y
M
S
P
E
R
L
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
G
C
---------PM
A
I
F
-------------
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
GVFS
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
-
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
77.09
40%
-25
- C1 -
-
3OS3
2
MP2K1_HUMAN
A:
[14-286]
----------------------------------------------------------------
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
L
H
E
C
N
--
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
K
K
A
GR
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
-
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
--
I
D
S
M
A
N
S
F
V
G
T
R
S
Y
M
S
P
E
R
L
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
-----------
M
A
I
F
E
L
L
--
D
Y
--
I
V
N
-------------
E
P
--------
P
P
K
L
P
-VFSL-
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
76.92
38%
-29
- C1 -
-
5HZE
1
MP2K1_HUMAN
A:
[32-331]
----------------------------------------------------
D
F
E
K
I
S
E
-----
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
L
H
E
C
N
--
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
K
K
A
GR
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
----
H
R
D
V
K
P
S
N
I
L
V
N
S
R
-
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
--
I
D
S
M
A
N
S
F
V
G
T
R
S
Y
M
S
P
E
R
L
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
-----------PM
A
I
F
-------------
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
GVFS
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
76.53
39%
-11
- C1 -
-
4AN9
2
MP2K1_HUMAN
A:
[10-282]
----------------------------------------------------
D
F
E
K
I
S
E
-----
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
L
H
E
C
N
--
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
K
K
A
GR
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
-
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
--
I
D
E
M
A
N
E
-
V
G
T
R
S
Y
M
S
P
E
R
L
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
R
P
P
M
----------
A
I
F
E
L
L
--
D
Y
--
I
V
N
-------------
E
P
--------
P
P
K
L
P
S
AVFS
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
73.27
37%
-10
- C1 -
-
5KKR
-
MP2K1_RABIT
C:
[69-368]
----------------------------------------------------
D
F
E
K
I
S
E
-----
L
G
A
G
---
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
L
H
E
C
N
--
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
K
K
AGR
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
-
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
--
I
D
S
M
A
N
S
F
V
G
T
R
S
Y
M
S
P
E
R
L
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
G
C
--------------PMAIFELLDYIVN
E
P
--------
P
P
K
L
P
S
AVFSL
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------