@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_36_0960: (2018-03-13 )
MADGYHNKPAAPKVGQRFGPYQVGDTIGRGTFAKVKIGYHETTKVRVALKIISRKLMESDARSALKIKREIKIMRVLRHPHITRLYDVVKTKHDIVLAMEYVSGGELFDYVTCKGRLEEPTARALFQQLTAAVAYCHRYRVTHRDIKPENIMMEHGCHSVKLSDFGLSSITHDGRFFETSCGTPNYASPEVVSGRLYGGPEADVWSCGVVLYAMLCGTLPFDDSNIALLFKKIQTADYAIPSHVSAQARDLLHRVLVVNPLERATMEQVMQHPWLRPDFPRYLLSLHFAAIVETTRFASTYYLTEDMLDEEVVRVVASRFRVSPQEVASIIMSEEERIPSMRAVISDEDNPNSMARRYPAANYFEMYSNVLDSKLWPTPVEIAAAEVALRDEAHDIYVSYVILTQKKQNKLAPQEHAANPSFGESANSLLQSQAQQGYGSLNANSLQQLTGNSSFTGLSFKETSSRSHTDASSSPASKKSNHHNGKTLQNLSSPLQHIMNSTVPAAPPGDPWQSGYNVVAAPFLPLHAKGATGTVLGQLLRVQELPVQLLMSRRITVKPVKKEASSTMFLSPGLPKSTPGFDCISDTGAAPTSMPTAPQGNLLQPQRSPTTRTRSAAPTLLHPHSKVEVGLSDPHSPIPTGRPMRSIGADARHNLATAGGETALDTLYHAETVTRFGNDFIRNGVAFVNSTSHETLQEVYEAMKEEGLLWKVIYDYYFSVVRYPNIKLQVKVYKTKSDEQLVDVKVSAQSGMAAYDVALSLLERLRTRAVNKRNTQIRESHASALTPDTT
Atome Classification :
(21 SA)
.........10........20........30........40........50......-..60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MADGYHNKPAAPKVGQRFGPYQVGDTIGRG
T
F
A
K
V
K
I
GYHET
T
K
V
R
V
A
L
K
I
I
S
R
K
L
M
-
E
S
D
A
R
S
A
L
K
I
K
R
E
I
K
I
M
R
V
L
RHP
H
I
T
R
L
Y
D
V
V
KTKH
D
I
V
L
A
M
E
YVSGG
E
L
F
D
Y
V
TCKGRLEE
P
T
A
R
A
L
F
Q
Q
L
T
A
A
V
A
Y
C
H
R
YRVTHRDIKPE
N
I
M
MEHGC
H
S
V
K
LSDFG
L
S
SITHD
G
R
F
F
ETSCGTPNYASPEVVS
G
R
LYGGPE
A
D
V
W
S
C
G
V
V
L
Y
A
M
L
CGTLPFDDS
N
I
A
L
L
F
K
K
IQTADYAIPSH
V
S
A
Q
A
R
D
L
L
H
R
V
L
VVN
P
L
E
R
A
T
M
E
Q
V
M
QHPWLRP
D
F
P
R
Y
L
L
S
L
H
F
A
A
I
V
E
TTRF
A
S
T
Y
Y
L
T
E
D
M
L
D
E
E
V
V
R
V
V
A
S
R
FRV
S
P
Q
E
V
A
S
I
I
M
S
E
E
E
RI
P
S
M
R
A
V
ISDEDN
P
N
S
M
A
R
RYP
A
A
N
Y
F
E
M
Y
S
N
V
L
DSKLWPT
P
V
E
I
A
A
A
E
V
A
LRDEA
H
D
I
Y
V
S
Y
V
I
L
TQKKQNKLA
P
Q
EHAANPSFG
E
S
A
N
S
L
L
Q
S
Q
A
Q
QGYGSL
N
A
N
S
L
Q
Q
L
TGNSSFT
G
L
S
F
KETSSRSHTDASSSPASKKSNHHNG
K
T
L
Q
N
L
S
S
P
L
Q
H
I
M
NSTVPAAPPGD
P
W
QSGY
N
V
V
AA
P
F
L
PLHAKGA
T
G
T
V
L
G
Q
L
L
R
V
Q
EL
P
V
Q
L
L
M
SRR
I
T
V
K
PVKKEASS
T
M
F
LSPGLPKSTPGFDCISDTGAAPTSMPTAPQGNLLQPQRSPTTRTRSAAPTLLHPH
S
K
V
E
VGLSDPHSPIPTGR
P
M
R
S
IGA
D
A
RHNLATAGG
E
T
A
L
D
T
L
Y
H
A
E
T
V
T
R
F
G
N
D
F
I
RN
G
V
AFVNST
S
H
E
T
L
Q
E
V
Y
E
A
M
K
EEGL
L
W
K
V
I
Y
D
Y
Y
F
S
V
VRYP
N
I
K
L
Q
V
K
V
Y
KTKSD
E
Q
L
V
D
V
K
V
SAQSGM
A
A
Y
D
V
A
L
S
L
L
E
R
L
R
T
RAVNKRN
T
Q
I
R
E
SHASALTPDTT
2
PsiBlast_PDB
91.55
47%
-142
- C1 -
-
5EZV
2
AAPK1_HUMAN (first)
A:
[26-423]
----------------
K
I
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
-
R
S
-
L
D
V
V
G
K
I
K
R
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
G
R
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
-
A
H
M
N
A
K
I
A
D
F
G
L
S
N
M
M
S
D
G
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
G
P
E
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
E
H
V
P
T
L
F
K
K
I
R
G
G
V
F
Y
I
P
E
Y
L
N
R
S
V
A
T
L
L
M
H
M
L
Q
V
D
P
L
K
R
A
T
I
K
D
I
R
E
H
E
W
F
K
Q
D
L
P
S
Y
L
-------------
F
P
E
D
P
S
Y
D
A
N
V
I
D
D
E
A
V
K
E
V
C
E
K
F
E
C
T
E
S
E
V
M
N
S
L
Y
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
87.79
47%
-136
- C1 -
-
5ISO
2
?
A:
[12-403]
----------------
K
I
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
-
R
S
-
L
D
V
V
G
K
I
K
R
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
G
R
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
H
M
N
A
-
K
I
A
D
F
G
L
S
N
M
M
S
D
G
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
G
P
E
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
E
H
V
P
T
L
F
K
K
I
R
G
G
V
F
Y
I
P
E
Y
L
N
R
S
V
A
T
L
L
M
H
M
L
Q
V
D
P
L
K
R
A
T
I
K
D
I
R
E
H
E
W
F
K
Q
D
L
P
S
Y
L
-------------
F
P
E
D
P
S
Y
D
A
N
V
I
D
D
E
A
V
K
E
V
C
E
K
F
E
C
T
E
S
E
V
M
N
S
L
Y
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
87.42
47%
-143
- C1 -
-
4RED
-
AAPK1_HUMAN
B:
[14-319]
----------------
K
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
A
V
A
V
K
I
L
N
R
Q
K
I
-
R
S
-
L
D
V
V
G
K
I
R
R
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
H
-
M
N
A
K
I
A
D
F
G
L
S
N
M
M
S
D
G
--------
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
D
H
V
P
T
L
F
K
K
I
C
D
G
I
F
Y
T
P
Q
Y
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
S
I
K
D
I
R
E
H
E
W
F
K
Q
D
L
P
K
Y
L
F
P
E
D
P
-------------
S
Y
S
T
T
M
I
D
D
E
A
L
K
E
V
C
E
K
F
E
C
S
E
E
E
V
L
S
C
L
Y
N
R
N
H
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
85.40
45%
-115
- C1 -
-
4RER
2
AAPK1_HUMAN
A:
[4-388]
----------------
K
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
-
R
S
-
L
D
V
V
G
K
I
R
R
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
H
M
N
A
-
K
I
A
D
F
G
L
S
N
M
M
S
D
G
E
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
D
H
V
P
T
L
F
K
K
I
C
D
G
I
F
Y
T
P
Q
Y
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
S
I
K
D
I
R
E
H
E
W
F
K
Q
D
L
P
K
Y
L
F
P
-------
E
D
P
S
Y
S
----------
D
D
E
A
L
K
E
V
C
E
K
F
E
C
S
E
E
E
V
L
S
C
L
Y
N
R
N
H
Q
D
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
84.11
52%
-136
- C1 -
-
3AQV
1
AAPK2_HUMAN
A:
[6-273]
-------------
G
R
V
K
I
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
-
R
-
S
L
D
V
V
G
K
I
K
R
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
G
R
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
H
-
M
N
A
K
I
A
D
F
G
L
S
N
M
M
S
D
G
E
F
L
------
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
G
P
E
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
E
H
V
P
T
L
F
K
K
I
R
G
G
V
F
Y
I
P
E
Y
L
N
R
S
V
A
T
L
L
M
H
M
L
Q
V
D
P
L
K
R
A
T
I
K
D
I
R
E
H
E
W
F
K
Q
D
L
P
S
Y
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
82.09
52%
-134
- C1 -
-
3AQV
1
AAPK2_HUMAN
A:
[9-274]
----------------
K
I
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
-
R
S
-
L
D
V
V
G
K
I
K
R
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
G
R
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
H
M
N
A
-
K
I
A
D
F
G
L
S
N
M
M
S
D
G
E
F
L
------
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
G
P
E
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
E
H
V
P
T
L
F
K
K
I
R
G
G
V
F
Y
I
P
E
Y
L
N
R
S
V
A
T
L
L
M
H
M
L
Q
V
D
P
L
K
R
A
T
I
K
D
I
R
E
H
E
W
F
K
Q
D
L
P
S
Y
L
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
81.81
52%
-138
- C1 -
-
2YZA
-
AAPK2_HUMAN
A:
[12-277]
----------------
K
I
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
-
R
S
-
L
D
V
V
G
K
I
K
R
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
G
R
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
H
M
N
A
-
K
I
A
D
F
G
L
S
N
M
M
S
D
-----------
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
G
P
E
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
E
H
V
P
T
L
F
K
K
I
R
G
G
V
F
Y
I
P
E
Y
L
N
R
S
V
A
T
L
L
M
H
M
L
Q
V
D
P
L
K
R
A
T
I
K
D
I
R
E
H
E
W
F
K
Q
D
L
P
S
Y
L
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
79.80
47%
-138
- C1 -
-
4RED
-
AAPK1_HUMAN
A:
[14-319]
----------------
K
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
A
V
A
V
K
I
L
N
R
Q
K
I
-
R
S
-
L
D
V
V
G
K
I
R
R
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
H
-
M
N
A
K
I
A
D
F
G
L
S
N
M
M
S
D
---------
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
D
H
V
P
T
L
F
K
K
----
I
F
Y
T
P
Q
Y
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
S
I
K
D
I
R
E
H
E
W
F
K
Q
D
L
P
K
Y
L
F
P
E
D
P
-------------
S
Y
S
T
T
M
I
D
D
E
A
L
K
E
V
C
E
K
F
E
C
S
E
E
E
V
L
S
C
L
Y
N
R
N
H
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
79.52
51%
-148
- C1 -
-
3HYH
-
SNF1_YEAST
A:
[54-315]
-------------------
N
Y
Q
I
V
K
T
L
G
E
G
---
K
V
K
L
A
Y
H
T
T
T
G
Q
K
V
A
L
K
I
I
N
K
K
------
M
Q
G
--
R
I
E
R
E
I
S
Y
L
R
L
L
R
H
P
H
I
I
K
L
Y
D
V
I
K
S
K
D
E
I
I
M
V
I
E
Y
-
A
G
N
E
L
F
D
Y
I
V
Q
R
D
K
M
S
E
Q
E
A
R
R
F
F
Q
Q
I
I
S
A
V
E
Y
C
H
R
H
K
I
V
H
R
D
L
K
P
E
N
L
L
L
D
E
H
L
-
N
V
K
I
A
D
F
G
L
S
---------------
P
N
Y
A
A
P
E
V
I
S
G
K
L
Y
A
G
P
E
V
D
V
W
S
C
G
V
I
L
Y
V
M
L
C
R
R
L
P
F
D
D
E
S
I
P
V
L
F
K
N
I
S
N
G
V
Y
T
L
P
K
F
L
S
P
G
A
A
G
L
I
K
R
M
L
I
V
N
P
L
N
R
I
S
I
H
E
I
M
Q
D
D
W
F
K
V
D
L
P
E
Y
L
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
76.88
45%
-132
- C1 -
-
4RED
-
AAPK1_HUMAN
A:
[14-321]
----------------
K
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
A
V
A
V
K
I
L
N
R
Q
K
I
-
R
S
-
L
D
V
V
G
K
I
R
R
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
H
M
N
A
-
K
I
A
D
F
G
L
S
N
M
M
S
D
---------
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
D
H
V
P
T
L
F
K
K
----
I
F
Y
T
P
Q
Y
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
S
I
K
D
I
R
E
H
E
W
F
K
Q
D
L
P
K
Y
L
F
P
-------
E
D
P
S
Y
S
T
T
------
M
I
D
D
E
A
L
K
E
V
C
E
K
F
E
C
S
E
E
E
V
L
S
C
L
Y
N
R
N
H
Q
D
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
75.88
42%
-122
- C1 -
-
2QNJ
-
MARK3_HUMAN
B:
[48-311]
------------
D
E
Q
P
H
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
R
E
V
A
I
K
I
I
D
K
T
Q
L
-
N
P
--
T
S
L
Q
K
L
F
R
E
V
R
I
M
K
I
L
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
I
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
R
M
K
E
K
E
A
R
S
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
R
I
V
H
R
D
L
K
A
E
N
L
L
L
D
A
D
-
M
N
I
K
I
A
D
F
G
F
S
N
E
F
T
---
K
L
D
T
F
C
G
S
P
P
Y
A
A
P
E
L
F
Q
G
K
K
Y
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
Q
N
L
K
E
L
R
E
R
V
L
R
G
K
Y
R
I
P
F
Y
M
S
T
D
C
E
N
L
L
K
R
F
L
V
L
N
P
I
K
R
G
T
L
E
Q
I
M
K
D
R
W
I
N
A
G
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
75.48
45%
-138
- C1 -
-
4D28
-
CIPKO_ARATH
A:
[8-268]
-----------------
V
G
K
Y
E
V
G
R
T
I
-----
A
K
V
K
F
A
R
N
T
D
T
G
D
N
V
A
I
K
I
M
A
K
S
T
I
-
L
K
N
-
R
M
V
D
Q
I
K
R
E
I
S
I
M
K
I
V
R
H
P
N
I
V
R
L
Y
E
V
L
A
S
K
S
K
I
Y
I
V
L
E
F
V
T
G
G
E
L
F
D
R
I
V
H
K
G
R
L
K
E
D
E
S
R
K
Y
F
Q
Q
L
V
D
A
V
A
H
C
H
S
K
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
D
T
N
-
G
N
L
K
V
S
D
F
G
L
S
A
L
P
Q
E
G
--
L
N
D
T
C
G
T
P
N
Y
V
A
P
E
V
L
S
G
Q
G
Y
D
G
S
A
A
D
I
W
S
C
G
V
I
L
F
V
I
L
A
G
Y
L
P
F
S
E
T
D
L
P
G
L
Y
R
K
I
N
A
A
E
F
D
C
P
P
W
F
S
A
E
V
K
F
L
I
H
R
I
L
D
P
N
P
K
T
R
I
Q
I
Q
G
I
K
K
D
P
W
F
R
K
N
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
73.79
42%
-114
- C- -
-
3FE3
-
MARK3_HUMAN
B:
[50-311]
--------------
Q
P
H
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
R
E
V
A
I
K
I
I
D
K
T
Q
L
-
N
P
--
T
S
L
Q
K
L
F
R
E
V
R
I
M
K
I
L
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
I
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
R
M
K
E
K
E
A
R
S
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
R
I
V
H
R
D
L
K
A
E
N
L
L
L
D
A
D
-
M
N
I
K
I
A
D
F
G
F
S
N
E
F
T
V
G
G
K
L
D
A
F
C
G
A
P
P
Y
A
A
P
E
L
F
Q
G
K
K
Y
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
Q
N
L
K
E
L
R
E
R
V
L
R
G
K
Y
R
I
P
F
Y
M
S
T
D
C
E
N
L
L
K
R
F
L
V
L
N
P
I
K
R
G
T
L
E
Q
I
M
K
D
R
W
I
N
A
G
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
72.37
43%
-122
- C1 -
-
2QNJ
-
MARK3_HUMAN
A:
[54-307]
------------------
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
R
E
V
A
I
K
I
I
D
K
T
Q
L
---
N
P
T
S
L
Q
K
L
F
R
E
V
R
I
M
K
I
L
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
I
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
R
M
K
E
K
E
A
R
S
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
R
I
V
H
R
D
L
K
A
E
N
L
L
L
D
A
D
M
N
-
I
K
I
A
D
F
G
F
S
N
E
F
T
-----
D
T
F
C
G
S
P
P
Y
A
A
P
E
L
F
Q
G
K
K
Y
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
Q
N
L
K
E
L
R
E
R
V
L
R
G
K
Y
R
I
P
F
Y
M
S
T
D
C
E
N
L
L
K
R
F
L
V
L
N
P
I
K
R
G
T
L
E
Q
I
M
K
D
R
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
71.56
51%
-56
- C1 -
-
3DAE
-
SNF1_YEAST
A:
[49-315]
--------------
G
A
H
I
G
N
Y
Q
I
V
K
T
L
G
E
G
S
F
G
K
V
K
L
A
Y
H
T
T
T
G
Q
K
V
A
L
K
I
I
N
K
K
V
L
A----
Q
G
--
R
I
E
R
E
I
S
Y
L
R
L
L
R
H
P
H
I
I
K
L
Y
D
V
I
K
S
K
D
E
I
I
M
V
I
E
Y
-
A
G
N
E
L
F
D
Y
I
V
Q
R
D
K
M
S
E
Q
E
A
R
R
F
F
Q
Q
I
I
S
A
V
E
Y
C
H
R
H
K
I
V
H
R
D
L
K
P
E
N
L
L
L
D
E
H
L
-
N
V
K
I
A
D
F
----------------
G
S
P
N
Y
A
A
P
E
V
I
S
G
K
L
Y
A
G
P
E
V
D
V
W
S
C
G
V
I
L
Y
V
M
L
C
R
R
L
P
F
D
D
E
S
I
P
V
L
F
K
N
I
S
N
G
V
Y
T
L
P
K
F
L
S
P
G
A
A
G
L
I
K
R
M
L
I
V
N
P
L
N
R
I
S
I
H
E
I
M
Q
D
D
W
F
K
V
D
L
P
E
Y
L
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
71.50
43%
-141
- C1 -
-
5KZ7
1
MARK2_HUMAN
A:
[33-286]
------------------
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
I
D
K
T
Q
L
-
N
S
S
--
S
L
Q
K
L
F
R
E
V
R
I
M
K
V
L
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
R
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
L
D
A
D
M
-
N
I
K
I
A
D
F
----------------
G
S
P
P
Y
A
A
P
E
L
F
Q
G
K
--
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
--
N
L
K
E
L
R
E
R
V
L
R
G
K
Y
R
I
P
F
Y
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
R
G
T
L
E
Q
I
M
K
D
R
W
M
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
71.30
42%
-138
- C1 -
-
5K00
1
MELK_HUMAN
A:
[5-266]
---------------
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
--
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
N
T
L
-
G
S
---
D
L
P
R
I
K
T
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
-
H
K
L
K
L
I
D
F
G
L
C
A
K
P
-----------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
S
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
K
Y
D
V
P
K
W
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
K
N
L
L
N
H
P
W
I
M
Q
D
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
70.26
43%
-133
- C1 -
-
5KZ8
1
MARK2_HUMAN
A:
[33-286]
------------------
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
I
D
K
T
Q
L
-
N
S
S
--
S
L
Q
K
L
F
R
E
V
R
I
M
K
V
L
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
R
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
L
D
A
D
M
-
N
I
K
I
A
D
F
G
--------------
C
G
S
P
P
Y
A
A
P
E
L
F
Q
G
K
K
Y
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
Q
N
L
K
E
L
R
E
R
V
L
R
G
K
Y
R
I
P
F
Y
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
R
G
T
L
E
Q
I
M
K
D
R
W
M
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
69.78
43%
-117
- C- -
-
3FE3
-
MARK3_HUMAN
A:
[54-307]
------------------
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
R
E
V
A
I
K
I
I
D
K
--
T
-
Q
L
N
P
T
S
L
Q
K
L
F
R
E
V
R
I
M
K
I
L
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
I
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
R
M
K
E
K
E
A
R
S
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
R
I
V
H
R
D
L
K
A
E
N
L
L
L
D
A
D
M
-
N
I
K
I
A
D
F
G
F
S
N
E
F
T
V
G
G
K
L
D
A
F
C
G
A
P
P
Y
A
A
P
E
L
F
Q
G
K
K
Y
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
Q
N
L
K
E
L
R
E
R
V
L
R
G
K
Y
R
I
P
F
Y
M
S
T
D
C
E
N
L
L
K
R
F
L
V
L
N
P
I
K
R
G
T
L
E
Q
I
M
K
D
R
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
69.52
43%
-134
- C- -
-
2R0I
-
MARK2_RAT
A:
[51-304]
------------------
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
I
D
K
T
Q
L
-
N
S
S
--
S
L
Q
K
L
F
R
E
V
R
I
M
K
V
L
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
R
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
L
D
A
D
M
-
N
I
K
I
A
D
F
----------------
G
S
P
P
Y
A
A
P
E
L
F
Q
G
K
K
Y
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
Q
N
L
K
E
L
R
E
R
V
L
R
G
K
Y
R
I
P
F
Y
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
R
G
T
L
E
Q
I
M
K
D
R
W
M
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
69.33
43%
-122
- C1 -
-
5EAK
1
MARK2_HUMAN
A:
[15-268]
------------------
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
I
D
K
T
Q
L
-
N
S
S
--
S
L
Q
K
L
F
R
E
V
R
I
M
K
V
L
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
R
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
L
D
A
D
M
-
N
I
K
I
A
D
F
G
F
S
-----------
F
C
G
S
P
P
Y
A
A
P
E
L
F
Q
G
K
K
Y
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
Q
N
L
K
E
L
R
E
R
V
L
R
G
K
Y
R
I
P
F
Y
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
R
G
T
L
E
Q
I
M
K
D
R
W
M
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------