@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_36_4460: (2018-03-13 )
LCVHFSRFMMMKSYRPPASFQQGRYIPNKVLGTGTYGQVIRCYDTVMGKDVAVKVAQSDAAYRRSALNEISALLCLKENEDSVNILDSFEDAGHVCIVSELLDRNLFEVLRNRGFGPLSLREVRQVALRVLSALASLHNSGYIHCDIKPENIMLRRSTPVSSDSSSPMLGPFTSENASSRSSNKSGEQNNFPNALAPGQEALKLDTNANVHNQLWRNTSSIDSLVGSTHSAAFQDGDLNMGFSPRTGNRLGGYSKQQHGQRGSGDATASISGAGMRHSGSLDGLFGMPAAAVGASGTGNNTRNDLRVNRNTLGNKDSESQERTQFNPDANPYCRTCLIDFGAVRRFNENTYYDVQSLWYRAPEVVCGLPYTTAIDSWSVGCVLFELFTGKPLFPGESLQHQLSLIVQHVGHPSQAALTLGCLATQFQLPMVYMSHDARREHVRQWILSSREAGLQRWRKHQMQKLQEAHIAGNQPLWSHPTADVPSTKSEEDALLTATPYGESDVDGASEELELLVDLVCDLLNPDESQRLSCTQALRHPFLNNASKCRSAAPCPCTATPAACFPAVSAAPAPMPCIMATTTTVQPVMMTASPLSVPMGCSPASPFVMHPVHSAPAATVPFTVAPLESMVGVEMEVSTLGVSSQHQPPQAFSTYPAVAASTVYTTNSTGQVMQCTVPVFTQVTHQVAPNVGHAFLPLGMTAQNPAGGTYCSPTTTASQQQYPPSGMSISPTFSPRGALVHAHVPLGFTPTTASNPAAVAAPAASVQPLGASSYVLASAGTVPCMHDYHSEMASAGMSPYVLCHFQPPHACATVMSP
Atome Classification :
(22 SA)
.........10........20........30........40...-.....-50........60........70.....-..-----.-----80.-----....-----...90------........100.-......110.--......120.......130.....--.--.140.......150..----.....160-----------------........170.......180.......190.......200.......210.......220.......230.......240.......250...--....260.......270..-.....280....------...--290.......300.......310.......320.......330.......340......--.350.......360......-.370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
LCV
H
F
S
R
F
M
M
M
K
SYRPPASFQQGRYIPNKVLGTGT
Y
G
Q
V
I
R
C
Y
D
-
T
VMGK-
D
V
A
V
K
V
AQS
D
A
A
Y
R
R
S
A
L
N
E
I
S
A
L
L
C
L-KE-----N-----EDS-----V
N
I
L
-----
D
SFED------AGH
V
C
I
V
S
E
L
L
D
-
R
N
L
F
E
V
L
R
NR--GFGPL
S
L
R
E
V
R
Q
V
A
L
R
V
L
S
A
L
A
S
L
--H--NS
G
Y
I
H
C
DIKPE
N
I
M
L
----RRSTPVS------------------SDSSSPMLGPFTSENASSRSSNKSGEQNNFPNALAPGQ
E
A
L
K
LDTNA
N
V
H
N
Q
L
W
RNT
S
S
I
D
S
L
VGSTHSAAFQDGDLNMGFSPRTGNRLGGYS
K
--
Q
QHGQRGSGDA
T
A
SISGAG-MRHSGSLDGLFG------MP
A
--
A
AVGASGTGNNTRN
D
L
R
VNRNTLGNKDSE
S
Q
E
RTQFNPDAN
P
Y
C
R
T
C
L
I
D
F
G
A
V
R
RFNE--N
T
Y
Y
D
V
Q
S
L
W
YRA
P
E
V
VCGL-PYTTAIDSW
S
V
G
C
V
L
F
E
LFTGKPLFP
G
E
S
L
Q
H
Q
L
S
L
I
V
Q
HVGH
P
S
Q
A
A
L
T
L
G
C
L
A
T
QFQL
P
M
V
Y
MS
H
D
A
R
R
E
H
V
R
Q
W
I
L
S
S
R
E
A
G
L
Q
R
W
R
K
H
Q
M
Q
K
L
Q
E
A
HIAGNQPLWSHPTADVPSTKSEE
D
A
L
L
T
ATPYGESDVDG
A
S
E
E
L
E
L
L
V
D
L
V
C
D
LLNPD
E
S
Q
R
L
S
C
T
Q
A
L
RHPFLN
N
A
S
K
CRSAAPCPCTATP
A
A
C
FPAVSAAPAPM
P
C
I
M
ATTTTV
Q
P
V
M
MTASPLSVPMGCSPASP
F
V
MHPVHSAPAATV
P
F
T
VA
P
L
E
S
M
VG
V
E
M
E
V
S
TLGVSSQHQPPQAFSTYPA
V
A
A
S
T
V
Y
TTNSTG
Q
V
M
Q
CT
V
P
V
F
T
Q
V
T
H
Q
VAPNVGH
A
F
LPLGMTAQNPAGGTYCSPTTTASQQQYPPSG
M
S
ISPTFSPR
G
A
L
V
H
AHVPLGFTPTTASNPAAVAAPAASVQPLGAS
S
Y
V
L
ASAGTV
P
C
M
H
D
Y
H
S
E
M
A
SAGMS
P
Y
V
L
C
HFQPPH
A
C
A
TVMSP
21
HHSearch
75.49
39%
-41
- C1 -
-
4AZF
1
DYRK2_HUMAN
A:
[94-324]
-------------------
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
H
K
V
H
Q
-
H
V
A
L
K
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
-
R
K
Q
D
K
DN
T
-----
M
N
V
-----
I
H
M
L
-----
E
N
F
T
F
------
R
N
H
I
C
M
T
F
E
L
L
S
-
M
N
L
Y
E
L
I
K
K
N
--
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
--
H
--
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
----
K
Q
Q
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
G
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
--
R
V
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
-
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
74.81
39%
-41
- C1 -
-
5LXC
8
DYRK2_HUMAN
A:
[71-302]
-----------------
H
D
H
V
A
Y
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
H
K
V
H
Q
-
H
V
A
L
K
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
-
R
K
Q
D
K
DN
T
-----
M
N
V
-----
I
H
M
L
-----
E
N
F
T
F
------
R
N
H
I
C
M
T
F
E
L
L
S
-
M
N
L
Y
E
L
I
K
K
N
--
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
--
H
--
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
----
K
Q
Q
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
G
I
K
V
I
D
F
G
S
S
C
Y
E
H
Q
--
R
V
Y
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
G
A
-
R
Y
G
M
P
I
D
M
W
S
L
G
C
I
L
A
E
L
L
T
G
Y
P
L
L
P
G
E
D
E
G
D
Q
L
A
C
M
I
E
L
L
G
M
P
S
Q
K
L
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
72.04
28%
-22
* C1 *
-
1J1B
1
GSK3B_HUMAN
B:
[53-346]
---------------------
E
V
S
Y
T
D
T
K
V
I
G
N
G
S
F
G
V
V
Y
Q
A
K
L
-
C
D
S
G
E
-
L
V
A
I
K
K
V
L
Q
D
K
---
R
F
K
N
R
E
L
Q
I
M
R
K
L
-
D
------
H
-----
C
N
I
-----
V
R
L
R
-----
Y
F
F
Y
S
S
GEKKD
E
V
Y
L
N
L
V
L
D
Y
V
P
-
E
T
V
Y
R
V
A
R
H
Y
S
R
A
K
Q
T
L
P
V
I
Y
V
K
L
Y
M
Y
Q
L
F
R
S
L
A
Y
I
--
H
--
S
F
G
I
C
H
R
D
I
K
P
Q
N
L
L
L
----
D
P
D
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
L
K
L
C
D
F
G
S
A
K
Q
L
V
R
G
E
P
N
V
S
Y
I
C
S
R
Y
Y
R
A
P
E
L
I
F
G
A
T
D
Y
T
S
S
I
D
V
W
S
A
G
C
V
L
A
E
L
L
L
G
Q
P
I
F
P
G
D
S
G
V
D
Q
L
V
E
I
I
K
V
L
G
T
P
T
R
E
Q
I
R
E
M
N
P
--
N
Y
----------------
T
-------
E
F
K
F
P
Q
I
K
A
--------------------------------------
H
P
W
T
K
---
V
F
R
P
R
T
P
P
E
A
I
A
L
C
S
R
L
L
E
Y
T
P
T
A
R
L
T
P
L
E
A
C
A
H
S
F
F
D
E
L
R
D
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
71.20
36%
-44
- C1 -
-
4YU2
2
DYR1A_HUMAN
A:
[26-257]
---------------
K
N
G
E
K
W
M
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
V
E
Q
E
-
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
-
N
K
H
D
TEM
K
-----
Y
Y
I
-----
V
H
L
K
-----
R
H
F
M
F
------
R
N
H
L
C
L
V
F
E
M
L
S
-
Y
N
L
Y
D
L
L
R
N
T
--
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
T
P
--
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
----
C
N
P
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
A
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
--
R
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
-
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
70.71
36%
-37
- C1 -
-
4YLL
8
DYR1A_HUMAN
A:
[26-263]
---------------
K
N
G
E
K
W
M
D
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
V
E
Q
E
-
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
-
N
K
H
D
TE-
K
-----
Y
Y
I
-----
V
H
L
K
-----
R
H
F
M
F
------
R
N
H
L
C
L
V
F
E
M
L
S
-
Y
N
L
Y
D
L
L
R
N
T
--
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
A
T
P
--
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
----
C
N
P
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
A
I
K
I
V
D
F
G
S
S
C
Q
L
G
Q
--
R
I
Y
Q
Y
I
Q
S
R
F
Y
R
S
P
E
V
L
L
G
M
-
P
Y
D
L
A
I
D
M
W
S
L
G
C
I
L
V
E
M
H
T
G
E
P
L
F
S
G
A
N
E
V
D
Q
M
N
K
I
V
E
V
L
G
I
P
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
66.13
30%
-21
- C1 -
-
1Z57
1
CLK1_HUMAN
A:
[3-251]
-----------
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
-
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
-
N
T
-----
T
D
P
NST
F
R
C
-----
V
Q
M
L
-----
E
W
F
E
H
------
H
G
H
I
C
I
V
F
E
L
L
G
-
L
S
T
Y
D
F
I
K
E
N
--
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
--
H
--
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
----
V
Q
S
D
Y
T
E
------------------
A
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
E
R
T
L
I
N
P
D
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
--
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
-
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
L
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
63.06
30%
-14
- C1 -
-
5J1W
6
CLK1_HUMAN
A:
[2-249]
----------
M
H
L
I
C
Q
S
G
D
V
L
S
A
R
Y
E
I
V
D
T
L
G
E
G
A
F
G
K
V
V
E
C
I
D
H
K
A
G
G
R
-
H
V
A
V
K
I
V
K
N
V
D
R
Y
C
E
A
A
R
S
E
I
Q
V
L
E
H
L
-
N
T
-----
T
D
P
NST
F
R
C
-----
V
Q
M
L
-----
E
W
F
E
H
------
H
G
H
I
C
I
V
F
E
L
L
G
-
L
S
T
Y
D
F
I
K
E
N
--
G
F
L
P
F
R
L
D
H
I
R
K
M
A
Y
Q
I
C
K
S
V
N
F
L
--
H
--
S
N
K
L
T
H
T
D
L
K
P
E
N
I
L
F
----
V
Q
S
D
Y
T
E
------------------
A
Y
N
--
P
K
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
D
E
R
T
L
I
N
P
D
I
K
V
V
D
F
G
S
A
T
Y
D
D
E
--
H
H
S
T
L
V
S
T
R
H
Y
R
A
P
E
V
I
L
A
L
-
G
W
S
Q
P
C
D
V
W
S
I
G
C
I
L
I
E
Y
Y
L
G
F
T
V
F
P
T
H
D
S
K
E
H
L
A
M
M
E
R
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
Fugue
56.00
19%
-1
- C1 -
-
1TKI
-
TITIN_HUMAN
A:
[18-338]
------------------
K
E
L
Y
E
K
Y
M
I
A
E
D
L
G
R
G
E
F
G
I
V
H
R
C
V
E
-
T
S
S
K
K
-
T
Y
M
A
K
F
V
K
V
K
G
T
D
Q
V
L
V
K
K
E
I
S
I
L
N
I
A
-
R
------
H
-----
R
N
I
-----
L
H
L
H
-----
E
S
F
E
S
------
M
E
E
L
V
M
I
F
E
F
I
S
G
L
D
I
F
E
R
I
N
T
S
--
A
F
-
E
L
N
E
R
E
I
V
S
Y
V
H
Q
V
C
E
A
L
Q
F
L
--
H
--
S
H
N
I
G
H
F
D
I
R
P
E
N
I
I
Y
QT--
R
R
S
S
T
I
K
IIEFGQARQLKPG
D
N
F
R
L
L
F
T
A
P
E
Y
Y
A
P
E
V
H
Q
H
D
V
V
S
T
A
T
D
M
W
S
L
G
T
L
V
Y
V
L
L
S
G
I
N
P
F
L
A
E
T
N
Q
Q
I
I
E
N
I
M
N
A
E
Y
T
F
D
E
E
A
F
K
E
I
S
I
E
A
M
D
F
V
D
R
L
-
L
V
K
E
R
K
S
R
M
T
A
S
E
A
--
L
Q
H
P
W
L
K
Q
K
I
E
R
V
S
T
K
V
I
R
T
L
K
H
R
R
Y
Y
H
T
L
I
K
KDLNMV
V
S
A
--
A
R
I
S
C
G
G
A
I
R
S
Q
K
G
V
S
V
A
K
V
K
V
A
S
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
55.40
32%
-46
- C1 -
-
4NCT
1
DYR1A_HUMAN
C:
[36-208]
-----------------------
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
V
E
Q
E
-
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
-
N
K
-----
H
-----
D
T
E
MKYYI
V
H
L
K
-----
R
H
F
M
F
------
R
N
H
L
C
L
V
F
E
M
L
S
-
Y
N
L
Y
D
L
L
R
N
T
--
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
--
A
TP
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
CNPK
R
S
A
I
K
I
V
------------------
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
Y
I
Q
S
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
51.88
32%
-41
- C1 -
-
5A3X
1
DYR1A_HUMAN
A:
[36-208]
-----------------------
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
V
E
Q
E
-
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
-
N
K
-----
H
-----
D
T
E
MKYYI
V
H
L
K
-----
R
H
F
M
F
------
R
N
H
L
C
L
V
F
E
M
L
S
-
Y
N
L
Y
D
L
L
R
N
T
--
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
--
A
TP
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
CNPK
R
S
A
I
K
I
V
------------------
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
Y
I
Q
S
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
Fugue
51.10
13%
-40
- C1 -
-
2RIO
1
IRE1_YEAST
A:
[8-434]
---------------
N
F
E
Q
S
L
K
N
L
V
V
S
E
K
I
L
G
Y
G
S
S
G
-
T
V
V
F
Q
G
-
S
F
Q
G
R
-
P
V
A
V
K
R
M
L
--
I
D
F
C
D
I
A
L
M
E
I
K
L
L
T
E
S
-
D
D
-----
H
-----
P
N
V
-----
I
R
Y
Y
-----
C
S
E
T
T
------
D
R
F
L
Y
I
A
L
E
L
C
N
-
L
N
L
Q
D
L
V
E
S
K
---------
Y
N
P
I
S
L
L
R
Q
I
A
S
G
V
A
H
L
--
H
--
S
L
K
I
I
H
R
D
L
K
P
Q
N
I
L
V
----
S
T
S
S
R
F
T
------------------
A
D
Q
Q
T
G
A
E
N
L
R
I
L
I
S
D
F
G
L
C
K
K
L
D
S
T
S
G
W
R
A
P
E
L
L
E
E
S
N
N
L
Q
T
K
R
R
L
T
R
S
I
D
I
F
S
M
G
C
V
F
Y
Y
I
L
-
S
K
G
K
H
P
F
G
D
K
Y
S
R
E
S
N
I
I
R
G
I
F
S
L
D
E
M
K
C
LH
D
R
S
L
I
A
E
A
T
D
L
I
S
Q
M
I
D
H
D
-
P
L
K
R
P
T
A
M
K
V
L
R
------
H
P
L
FW
P
K
S
K
K
L
E
F
L
L
K
V
S
D
R
L
E
I
E
N
R
D
P
P
S
A
L
L
M
K
F
D
A
G
S
D
F
V
I
P
S
G
D
W
T
V
K
F
D
K
T
F
M
D
R
K
Y
H
S
--
S
K
L
M
D
L
L
R
A
L
R
N
K
Y
H
H
F
M
D
L
-
P
E
D
I
A
E
L
M
G
P
V
P
D
G
F
Y
D
Y
F
T
K
R
F
P
N
L
L
I
G
V
Y
M
I
V
K
E
N
L
S
D
D
Q
I
L
R
E
F
L
Y
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
51.00
32%
-34
- C1 -
-
5A4T
1
DYR1A_HUMAN
A:
[36-208]
-----------------------
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
V
E
Q
E
-
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
-
N
K
-----
H
-----
D
T
E
MKYYI
V
H
L
K
-----
R
H
F
M
F
------
R
N
H
L
C
L
V
F
E
M
L
S
-
Y
N
L
Y
D
L
L
R
N
T
--
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
--
A
TP
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
CNPK
R
S
A
I
K
I
V
------------------
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
Y
I
Q
S
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
50.76
32%
-46
- C1 -
-
5A4L
1
DYR1A_HUMAN
A:
[36-208]
-----------------------
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
V
E
Q
E
-
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
-
N
K
-----
H
-----
D
T
E
MKYYI
V
H
L
K
-----
R
H
F
M
F
------
R
N
H
L
C
L
V
F
E
M
L
S
-
Y
N
L
Y
D
L
L
R
N
T
--
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
--
A
TP
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
CNPK
R
S
A
I
K
I
V
------------------
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
Y
I
Q
S
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
50.74
32%
-40
- C1 -
-
5A4Q
1
DYR1A_HUMAN
A:
[36-208]
-----------------------
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
V
E
Q
E
-
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
-
N
K
-----
H
-----
D
T
E
MKYYI
V
H
L
K
-----
R
H
F
M
F
------
R
N
H
L
C
L
V
F
E
M
L
S
-
Y
N
L
Y
D
L
L
R
N
T
--
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
--
A
TP
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
CNPK
R
S
A
I
K
I
V
------------------
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
Y
I
Q
S
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
50.72
27%
-113
- C1 -
-
1TKI
-
TITIN_HUMAN
A:
[20-153]
--------------------
L
Y
E
K
Y
M
I
A
E
D
L
G
R
G
E
F
G
I
V
H
R
C
V
E
-
T
S
S
K
K
-
T
Y
M
A
K
F
V
K
V
K
G
T
D
Q
V
L
V
K
K
E
I
S
I
L
N
I
A
-
R
------
H
-----
R
N
I
-----
L
H
L
H
-----
E
S
F
E
S
------
M
E
E
L
V
M
I
F
E
F
I
S
G
L
D
I
F
E
R
I
N
T
S
--
A
-
F
E
L
N
E
R
E
I
V
S
Y
V
H
Q
V
C
E
A
L
Q
F
L
--
H
--
S
H
N
I
G
H
F
D
I
R
P
E
N
I
I
Y
----
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
50.23
32%
-42
- C1 -
-
3ANQ
1
DYR1A_HUMAN
A:
[36-208]
-----------------------
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
V
E
Q
E
-
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
-
N
K
-----
H
-----
D
T
E
MKYYI
V
H
L
K
-----
R
H
F
M
F
------
R
N
H
L
C
L
V
F
E
M
L
S
-
Y
N
L
Y
D
L
L
R
N
T
--
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
--
A
TP
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
CNPK
R
S
A
I
K
I
V
------------------
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
Y
I
Q
S
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
49.70
32%
-42
- C1 -
-
3ANR
1
DYR1A_HUMAN
A:
[36-208]
-----------------------
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
V
E
Q
E
-
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
-
N
K
-----
H
-----
D
T
E
MKYYI
V
H
L
K
-----
R
H
F
M
F
------
R
N
H
L
C
L
V
F
E
M
L
S
-
Y
N
L
Y
D
L
L
R
N
T
--
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
--
A
TP
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
CNPK
R
S
A
I
K
I
V
------------------
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
Y
I
Q
S
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
49.33
32%
-50
- C1 -
-
4AZE
1
DYR1A_HUMAN
A:
[55-222]
-----------------------
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
V
E
Q
E
-
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
-
N
K
-----
H
-----
D
T
E
MKYYI
V
H
L
K
-----
R
H
F
M
F
------
R
N
H
L
C
L
V
F
E
M
L
S
-
Y
N
L
Y
D
L
L
R
N
T
--
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
--
A
TP
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
CNPK
R
S
A
I
K
I
V
------------------
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
Y
I
Q
S
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
49.28
32%
-45
- C1 -
-
5A4E
1
DYR1A_HUMAN
A:
[36-208]
-----------------------
R
Y
E
I
D
S
L
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
R
V
E
Q
E
-
W
V
A
I
K
I
I
K
N
K
K
A
F
L
N
Q
A
Q
I
E
V
R
L
L
E
L
M
-
N
K
-----
H
-----
D
T
E
MKYYI
V
H
L
K
-----
R
H
F
M
F
------
R
N
H
L
C
L
V
F
E
M
L
S
-
Y
N
L
Y
D
L
L
R
N
T
--
N
F
R
G
V
S
L
N
L
T
R
K
F
A
Q
Q
M
C
T
A
L
L
F
L
--
A
TP
E
L
S
I
I
H
C
D
L
K
P
E
N
I
L
L
CNPK
R
S
A
I
K
I
V
------------------
D
F
G
S
S
C
Q
L
G
Q
R
I
Y
Q
Y
I
Q
S
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
48.42
37%
-40
- C1 -
-
4AZF
1
DYRK2_HUMAN
A:
[98-238]
-----------------------
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
H
K
V
H
Q
-
H
V
A
L
K
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
-----
D
-----
K
D
N
TMN
V
-
I
H
M
L
-----
E
N
F
T
F
------
R
N
H
I
C
M
T
F
E
L
L
S
-
M
N
L
Y
E
L
I
K
K
N
--
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
--
H
--
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
----
K
Q
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
46.73
37%
-45
- C1 -
-
5LXC
6
DYRK2_HUMAN
A:
[77-214]
-----------------------
R
Y
E
V
L
K
V
I
G
K
G
S
F
G
Q
V
V
K
A
Y
D
-
H
K
V
H
Q
-
H
V
A
L
K
M
V
R
N
E
K
R
F
H
R
Q
A
A
E
E
I
R
I
L
E
H
L
R
K
Q
-----
D
-----
K
D
N
TMN
V
-
I
H
M
L
-----
E
N
F
T
F
------
R
N
H
I
C
M
T
F
E
L
L
S
-
M
N
L
Y
E
L
I
K
K
N
--
K
F
Q
G
F
S
L
P
L
V
R
K
F
A
H
S
I
L
Q
C
L
D
A
L
--
H
--
K
N
R
I
I
H
C
D
L
K
P
E
N
I
L
L
----
K
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
44.79
39%
-9
- C1 -
-
3RAW
1
CLK3_HUMAN
A:
[50-188]
---------------------
Q
E
R
Y
E
I
V
G
N
L
G
E
G
T
F
G
K
V
V
E
C
L
D
-
H
A
R
G
K
S
Q
V
A
L
K
I
I
R
N
V
G
K
Y
R
E
A
A
R
L
E
I
N
V
L
K
K
I
-
K
E
-----
K
-----
D
K
E
-----
N
K
F
L
CVLMS
D
W
F
N
F
------
H
G
H
M
C
I
A
F
E
L
L
G
-
K
N
T
F
E
F
L
K
E
N
--
N
F
Q
P
Y
P
L
P
H
V
R
H
M
A
Y
Q
L
C
H
A
L
R
F
L
--
H
--
E
N
Q
L
T
H
T
D
L
K
P
E
N
I
L
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------