@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LinJ_36_5580: (2018-03-13 )
MSHFCSSLSRTPPRGGAISMPRDLSQTPAISRLGSTVKTPHIQKCVVDQTEDDDHPLEHMTVYFEEEDLRLVTTGLLGKGGFGKVFDAVSNSGEAYALKVSSKRMSENDWKRLKEEVTLMSHFSRHPNIVKFYAAGRDEDRAYVVMERCAGKSLHDVIASRGLDVPEILWIGWALVNTISYIHSKGCIHRDLKPQNLLFDHEGNLKITDFGLSSRISEAHPRKTVAGTAMYMAPEMATEVYKRMTKNSDAPSLSYGKEVDTWSIGVVLYVLLTRMNPYLEAIEQKGMRQLDKEHKSLALFNAVAGAAWSWPREWRGDPQLCRLVERVLHREPSQRATLMEVLEDSVWNRRPLSCPLSLLQKLNLLEPSPSSGLPLNNLAENLQFRPKRSAEAVLREGLERIEATEQRGRAQLELEYYETYNVLWCLLTLARAEEDARADILQSEEVQRGKLRNQSLARQSARGRCGSVSLVSEVADREVAASRTSRSVRRSVSLTEQEQGRLVRSSPVQYAVVYPGRDTATRWNLRAVVSLPRDMTAEIEREFKCMNGHVMTKLTSMPHGYNGFDCNVCDRGILKITGESPAFRCYKCDYDVCMKCAYSGKFKDVNFVCVTCAKRFTSTAKLQGHTLRCRGPSESPSPRRSSRMNTMLWDEPKRPSLLEVQLPEAPQSEPKLRASRCRSGRPTYNRTSTGGRISIGDPNAHSVVDFDAMVAEHREADFPKVSARASATGRESSQKRERAGSRRGRPSTSSSGSLSLDLPPQVQVPSKESRAQVQPRSSAELRDIMEEVEQRKQALPRDPLLSGPATPPQYNCNGEIIGIAARRRAESLEMARAEVITIRAEVADRPRELQHQPRVPRSASSSRAEKGLQGSHKRRREEWKQSAHAPSPSGTAKRAAVEEHVAKHAIMPPQVPRGRAQQSRAPSVSGHTAQGGPPLPRRGPAAPFPAAALKAHLGAFQVPAAIPPKNFASILPSRYSMTNAMAPTCNTSTTRPADGAGAAAADLGRGGAPTYSHVLGRPNGAFLALPREERNRQQFLDDFLSGGWVRFYSFTNEDTVVMYYSLQPGRYGAMFPTEAGVGTAVLDVYSKLVLYVPCMNNESTNRSQPHPHVQTFYDEEARILSLPEAQRYLGGVLRCITGFVDEFSRLKAEGLTPAAVHAAYIHHRSMSHVPRDTKFVYIRKVFPDPSGSFTLFRLSNLRSQVVCNAMVDIRWQSDRRHNVGQKYYINADGTAEPFLVDQTGILSQLETVLNNNFRR
Atome Classification :
(20 SA)
---------------------------------------------------------------------------------------------.........10........20.....---...30...------------.....40........50------------------------........60........70.........80.......-.-90.-.-.-......-100....--.--..110.......120..-.....130.......140.......150.......160.---.......170.......180..-.-....190.......-------------200.......210.....-.-.---220.-........230.......240.......250.......260.......270.......280.......290........300.....--..310.......320.......330..--.-----.-----...340.....--.------.350.....------------------------..360.......370.......380.......390.......400.........410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250..
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
---------------------------------------------------------------------------------------------M
S
H
F
C
S
S
L
SRTPPRGGAISMPRDLSQ---T
P
A
I
S
R
LG------------STVKTP
H
I
Q
K
CVVDQTE------------------------DDDHPL
E
H
M
T
V
Y
F
EEED
L
R
-
L
V
T
TGLLGKGG
F
G
K
V
F
D
A
-V-S-N-S-G-
E
A
Y
A
L
K
-VSSKRMS--
E
--
N
D
W
K
R
L
K
E
E
V
T
L
M
S
H
F
S-RHP
N
I
V
K
F
Y
AAGRDED
R
A
Y
V
V
M
E
R
CAG
K
S
L
H
D
V
I
A
SR-G---LDV
P
E
I
L
W
I
G
W
A
L
V
N
T
I
S
Y
I
HS-K-GCIHRDLKPQ
N
L
L
F-------------DHEG
N
L
K
I
T
DFGLSSRIS-E-A---H--P-RKTVAGT
A
M
YM
A
P
E
M
A
T
E
V
Y
K
R
M
TKNSDAPSLSYGKEVD
T
W
S
I
G
V
V
L
Y
V
L
L
T
RM
N
P
Y
L
E
A
I
E
Q
K
G
M
R
Q
L
-
D
K
E
H
K
S
L
A
L
F
N
A
V
AGAA--WS
W
P
R
EWRG
D
P
Q
L
C
R
L
V
E
R
V
LHREPS
Q
--
R
-----
A
-----
T
L
M
E
V
L
E
D
S
VW--N------RRPLS
C
P
L
S
------------------------
L
L
Q
K
LNLLEPSPSSGLP
L
N
N
L
A
E
NLQFRPK
R
S
A
E
A
V
L
R
E
G
L
E
R
--
I
E
A
T
E
QRG
R
A
Q
L
E
L
E
Y
Y
E
T
Y
N
V
L
W
C
L
L
T
L
A
RAE
E
D
A
R
A
D
I
L
Q
S
E
E
V
Q
R
GKLR
N
Q
S
L
A
R
Q
SARGRCG
S
V
S
L
V
S
E
V
A
D
R
E
V
A
A
S
R
T
S
R
S
V
R
R
SVSL
T
E
Q
EQG
R
L
VRSSP
V
Q
Y
A
V
V
YPGRDTA
T
R
W
N
L
R
A
V
V
SLP
R
D
M
T
A
E
I
E
R
E
F
KCMN
G
H
V
M
T
K
LTSMPHGYNGFDCNVCDR
G
I
L
K
ITGESP
A
F
R
C
Y
KC
D
Y
D
V
C
M
K
C
AYSGKFKD
V
N
F
V
C
V
T
C
A
K
RFTSTAKLQG
H
T
L
R
CRGPSESPSPRRSSRMNTMLWDEPKRP
S
L
L
E
V
QLPEAPQSE
P
K
L
R
A
S
RCRSGRPTYNRTSTG
G
R
I
S
IGDPNAH
S
V
V
D
F
D
A
M
V
A
E
H
READFPKVSARASATGR
E
S
S
Q
K
R
E
R
AGSRRGRPSTSSSG
S
L
S
LDLPPQVQVPSKESRAQVQPR
S
S
A
E
L
R
D
I
M
E
E
V
E
Q
R
K
QALPRDPLLSGPATPPQYNCNG
E
I
I
G
I
A
A
RR
R
A
E
S
L
E
MA
R
A
E
V
I
T
I
R
A
EVADR
P
R
E
L
QHQPRVPRSAS
S
S
R
A
E
KGLQG
S
H
K
R
R
R
E
E
W
K
Q
SAHAPSPSGT
A
K
R
A
A
V
E
E
H
V
A
K
HAIMPPQVPRGRAQQSRAPSVSGHTAQGGPPLPRRGPAAPF
P
A
A
A
L
K
A
H
LGAFQVPAAI
P
P
K
N
F
A
S
I
L
P
S
R
YSMTNAMAPTCNTSTTRPADGAG
A
A
A
A
DLGRGGAP
T
Y
S
H
VLGRPNG
A
F
L
AL
P
R
EER
N
R
Q
Q
F
L
D
D
F
LSGG
W
V
R
F
Y
S
FTNE
D
T
V
V
M
Y
Y
SLQPGRYGAMFPTEAGV
G
T
A
V
L
D
V
Y
S
K
L
V
L
Y
V
PCMNNESTNRSQPHP
H
V
Q
T
F
Y
DEEA
R
I
LS
L
P
E
A
Q
R
Y
L
G
G
V
L
R
C
I
T
G
F
V
D
E
F
S
R
L
K
AEGL
T
P
A
A
V
H
A
A
Y
I
HHR
S
M
SHVPRD
T
K
F
V
Y
I
R
K
VFPDPSG
S
F
T
L
F
R
L
S
N
L
R
S
Q
V
V
C
N
A
M
V
D
I
R
WQSDRRHNVG
Q
K
Y
Y
INADGTAE
P
F
L
VD
Q
T
G
I
L
S
Q
L
E
T
V
L
NNNFRR
21
HHSearch
73.55
30%
-11
- C1 -
-
4CZT
4
CIPKN_ARATH
D:
[12-306]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
-
R
-
N
-
V
-
E
N
G
-
D
N
V
A
I
K
-
V
I
D
K
E
K
V
--
L
K
N
K
M
I
A
Q
I
K
R
E
I
S
T
M
K
L
I
--
K
H
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
-
G
R--
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
-
R
-
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
-------------
D
A
N
G
A
L
K
V
S
D
F
G
L
S
A
L
P
Q
-
Q
-
V
RED
G
--
L
-
L
H
T
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
------------
K
G
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
S
N
L
T
S
--------------
L
Y
K
K
I
F
K
A
E
--
F
T
C
P
P
-
W
-
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
--
R
-----
I
-----
T
F
A
E
V
I
E
N
E
W
F
--
K
------
K
G
Y
K
A
P
K
F
E
N
A
DVSLDDVDAIFDDSN
L
V
V
E
R
RE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
HHSearch
71.69
30%
1
* C1 *
-
4GV1
5
AKT1_HUMAN
A:
[9-279]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
-
K
-
E
-
K
-
A
T
G
-
R
Y
Y
A
M
K
-
I
L
K
K
E
V
I
V
A
K
--
D
E
V
A
H
T
L
T
E
N
R
V
L
Q
N
S
--
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
-
R
V--
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
-
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
-------------
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
-
K
D
G
---
A
--
T
-
M
K
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
-------------
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
E
K
--------------
L
F
E
L
I
L
M
E
E
--
I
R
F
P
R
T
--
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
-----
L
GGGS
E
D
A
K
E
I
M
Q
H
R
F
F
--
A
------
G
I
V
W
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
71.63
31%
-16
- C1 -
-
4XBR
1
INKA1_HUMAN (first)
A:
[95-351]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
-
T
-
V
-
R
S
S
-
G
-
K
L
V
A
V
K
-
K
M
D
L
R
K
Q
-----
Q
R
R
E
L
L
F
N
E
V
V
I
M
R
D
Y
--
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
T
-
R
---
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
-
Q
-
G
V
I
H
R
D
I
K
S
D
S
I
L
L
-------------
T
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
-
K
-
E
---
V
P-
R
-
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
R
-------------
L
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
----------
R
D
N
L
-
P
P
R
--
L
K
N
L
--
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
--
R
-----
A
-----
T
A
A
E
L
L
K
H
P
F
L
--
A
------
K
A
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
70.60
30%
-33
- C1 -
-
2CDZ
1
A:
[39-280]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
S
T
G
I
V
C
I
A
T
V
-
R
-----
G
-
K
L
V
A
V
K
-
K
M
D
L
R
K
Q
--
Q
--
R
R
-
E
L
L
F
N
E
V
V
I
M
R
D
Y
--
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
T
-
R
---
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
-
Q
-
G
V
I
H
R
D
I
K
S
D
S
I
L
L
-------------
T
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
-
K
-
E
---
V
--
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
R
-------------
L
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
K
N
L
H
K
V
S
---------------
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
--
R
-----
A
-----
T
A
A
E
L
L
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
69.61
30%
-36
- C1 -
-
4JDI
1
PAK4_HUMAN
A:
[82-323]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
S
T
G
I
V
C
I
A
T
V
-
R
-
S
-
S
-
G
-
K
L
V
A
V
K
-
K
M
D
L
R
K
Q
--
Q
--
R
R
-
E
L
L
F
N
E
V
V
I
M
R
D
Y
--
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
T
-
R
---
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
-
Q
-
G
V
I
H
R
D
I
K
S
D
S
I
L
L
-------------
T
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
-
K
-
E
---
V
--
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
R
-------------
L
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
K
N
L
H
K
V
S
---------------
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
--
R
-----
A
-----
T
A
A
E
L
L
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
HHSearch
68.81
26%
-23
- C1 -
-
4WOT
1
ROCK2_HUMAN
B:
[70-341]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
-
Y
D
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
-
R
-
H
-
K
-
A
-
S
Q
K
V
Y
A
M
K
-
L
L
S
K
F
E
M
I
K
R
--
S
D
S
A
F
F
W
E
E
R
D
I
M
A
F
-
A
-
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
Y
-
D
---
V
P
E
K
W
A
K
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
-
G
L
I
H
R
D
V
K
P
D
N
M
L
L
-------------
D
K
H
G
H
L
K
L
A
D
F
G
T
C
M
K
M
D
-
E
-
T
---
G
M
V
H
-
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
G
---------
G
D
G
F
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
T
P
F
Y
A
D
S
L
V
G
--------------
T
Y
S
K
I
M
D
H
K
NS
L
C
F
P
E
D
A
E
I
S
K
H
A
K
N
L
I
C
A
F
L
T
D
R
E
V
R
LG
R
-----
N
-----
G
V
E
E
I
R
Q
H
P
F
F
--
K
------
N
D
Q
W
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
68.79
30%
-36
- C1 -
-
4JDH
-
?
A:
[82-323]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
S
T
G
I
V
C
I
A
T
V
-
R
-
S
-
S
-
G
-
K
L
V
A
V
K
-
K
M
D
L
R
K
Q
--
Q
--
R
R
-
E
L
L
F
N
E
V
V
I
M
R
D
Y
--
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
T
-
R
---
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
-
Q
-
G
V
I
H
R
D
I
K
S
D
S
I
L
L
-------------
T
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
-
K
-
E
---
V
--
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
R
-------------
L
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
K
N
L
H
K
V
S
---------------
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
--
R
-----
A
-----
T
A
A
E
L
L
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
68.49
30%
-35
- C1 -
-
4XBU
-
PAK4_HUMAN
A:
[327-568]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
S
T
G
I
V
C
I
A
T
V
-
R
-
S
-
S
-
G
-
K
L
V
A
V
K
-
K
M
D
L
R
K
Q
--
Q
--
R
R
-
E
L
L
F
N
E
V
V
I
M
R
D
Y
--
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
T
-
R
---
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
-
Q
-
G
V
I
H
R
D
I
K
S
D
S
I
L
L
-------------
T
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
-
K
-
E
---
V
--
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
R
-------------
L
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
K
N
L
H
K
V
S
---------------
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
--
R
-----
A
-----
T
A
A
E
L
L
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
68.37
30%
-9
- C1 -
-
4CZU
3
CIPKN_ARATH
B:
[12-295]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
-
R
-
N
-
V
E
N
-
G
-
D
N
V
A
I
K
-
V
I
D
K
E
K
V
--
L
K
N
K
M
I
A
Q
I
K
R
E
I
S
T
M
K
L
I
--
K
H
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
-
G
R--
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
-
R
-
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
-------------
D
A
N
G
A
L
K
V
S
D
F
G
L
S
A
L
P
Q
-
Q
-
V
RED
G
--
L
-
L
H
D
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
------------
K
G
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
S
N
L
T
S
--------------
L
Y
K
K
I
F
K
A
E
--
F
T
C
P
P
-
W
-
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
--
R
-----
I
-----
T
F
A
E
V
I
E
N
E
W
F
--
K
------
K
G
Y
K
A
P
K
F
E
DDVDAIFDDSG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
68.16
30%
-29
- C1 -
-
2Q0N
7
A:
[37-278]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
S
T
G
I
V
C
I
A
T
V
-
R
-
S
-
S
-
G
-
K
L
V
A
V
K
-
K
M
D
L
R
K
Q
--
Q
--
R
R
-
E
L
L
F
N
E
V
V
I
M
R
D
Y
--
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
T
-
R
---
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
-
Q
-
G
V
I
H
R
D
I
K
S
D
S
I
L
L
-------------
T
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
-
K
-
E
---
V
--
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
R
-------------
L
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
K
N
L
H
K
V
S
---------------
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
--
R
-----
A
-----
T
A
A
E
L
L
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
68.09
30%
-36
- C1 -
-
4FIG
1
?
A:
[82-323]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
S
T
G
I
V
C
I
A
T
V
-
R
-
S
-
S
-
G
-
K
L
V
A
V
K
-
K
M
D
L
R
K
Q
--
Q
--
R
R
-
E
L
L
F
N
E
V
V
I
M
R
D
Y
--
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
T
-
R
---
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
-
Q
-
G
V
I
H
R
D
I
K
S
D
S
I
L
L
-------------
T
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
-
K
-
E
---
V
--
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
R
-------------
L
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
K
N
L
H
K
V
S
---------------
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
--
R
-----
A
-----
T
A
A
E
L
L
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
67.85
30%
-36
- C1 -
-
4FIE
1
PAK4_HUMAN
A:
[159-400]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
S
T
G
I
V
C
I
A
T
V
-
R
-
S
-
S
-
G
-
K
L
V
A
V
K
-
K
M
D
L
R
K
Q
--
Q
--
R
R
-
E
L
L
F
N
E
V
V
I
M
R
D
Y
--
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
T
-
R
---
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
-
Q
-
G
V
I
H
R
D
I
K
S
D
S
I
L
L
-------------
T
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
-
K
-
E
---
V
--
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
R
-------------
L
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
K
N
L
H
K
V
S
---------------
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
--
R
-----
A
-----
T
A
A
E
L
L
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
67.59
30%
-34
- C1 -
-
4FIF
1
PAK4_HUMAN
A:
[82-323]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
S
T
G
I
V
C
I
A
T
V
-
R
-
S
-
S
-
G
-
K
L
V
A
V
K
-
K
M
D
L
R
K
Q
--
Q
--
R
R
-
E
L
L
F
N
E
V
V
I
M
R
D
Y
--
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
T
-
R
---
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
-
Q
-
G
V
I
H
R
D
I
K
S
D
S
I
L
L
-------------
T
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
-
K
-
E
---
V
--
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
R
-------------
L
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
K
N
L
H
K
V
S
---------------
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
--
R
-----
A
-----
T
A
A
E
L
L
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
67.41
30%
-30
- C1 -
-
2J0I
4
A:
[39-280]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
S
T
G
I
V
C
I
A
T
V
-
R
-
S
-
S
-
G
-
K
L
V
A
V
K
-
K
M
D
L
R
K
Q
--
Q
--
R
R
-
E
L
L
F
N
E
V
V
I
M
R
D
Y
--
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
T
-
R
---
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
-
Q
-
G
V
I
H
R
D
I
K
S
D
S
I
L
L
-------------
T
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
-
K
-
E
---
V
--
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
R
-------------
L
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
K
N
L
H
K
V
S
---------------
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
--
R
-----
A
-----
T
A
A
E
L
L
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
67.38
30%
-31
- C1 -
-
4FII
-
PAK4_HUMAN
A:
[82-323]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
S
T
G
I
V
C
I
A
T
V
-
R
-
S
-
S
-
G
-
K
L
V
A
V
K
-
K
M
D
L
R
K
Q
--
Q
--
R
R
-
E
L
L
F
N
E
V
V
I
M
R
D
Y
--
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
T
-
R
---
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
-
Q
-
G
V
I
H
R
D
I
K
S
D
S
I
L
L
-------------
T
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
-
K
-
E
---
V
--
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
R
-------------
L
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
K
N
L
H
K
V
S
---------------
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
--
R
-----
A
-----
T
A
A
E
L
L
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
66.84
30%
-29
- C1 -
-
4XBR
1
INKA1_HUMAN (first)
A:
[102-343]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
S
T
G
I
V
C
I
A
T
V
-
R
-
S
-
S
-
G
-
K
L
V
A
V
K
-
K
M
D
L
R
K
Q
--
Q
--
R
R
-
E
L
L
F
N
E
V
V
I
M
R
D
Y
--
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
T
-
R
---
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
-
Q
-
G
V
I
H
R
D
I
K
S
D
S
I
L
L
-------------
T
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
-
K
-
E
---
V
--
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
R
-------------
L
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
L
P
P
R
L
K
N
L
H
K
V
S
---------------
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
--
R
-----
A
-----
T
A
A
E
L
L
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
Fugue
66.01
20%
-2
- C1 -
-
2RIO
1
IRE1_YEAST
A:
[8-434]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
F
E
Q
S
L
K
N
L
-
V
V
S
E
K
I
L
G
Y
G
S
S
G
T
V
V
F
Q
-
G
-
S
-
F
-
Q
-
G
-
R
----
P
-
V
A
V
K
R
M
L
--
I
--
D
F
C
D
I
A
L
M
E
I
K
L
L
T
E
S
D
-
D
H
P
N
V
I
R
Y
Y
C
S
E
T
T
D
R
F
L
Y
I
A
L
E
L
C
N
-
L
N
L
Q
D
L
V
E
S
K
--------
Y
N
P
I
S
L
L
R
Q
I
A
S
G
V
A
H
L
H
S
-
L
-
K
I
I
H
R
D
L
K
P
Q
N
I
L
V
S
TSSRFTADQQTG
A
E
N
L
R
I
L
I
S
D
F
G
L
C
-----------------
K
K
L
D
S
T
S
G
W
R
A
P
E
L
L
E
E
------
S
N
N
L
Q
T
K
R
R
L
T
R
S
I
D
I
F
S
M
G
C
V
F
Y
Y
I
L
S
K
G
K
H
P
F
G
D
-
K
Y
S
R
E
S
N
I
-
I
R
G
I
F
S
L
D
E
M
K
C
L
----------
H
D
R
S
L
I
A
E
A
T
D
L
I
S
Q
M
I
D
H
D
P
L
K
--
R
-----
P
-----
T
A
M
K
V
L
R
H
P
L
F
WP
K
------
S
K
K
L
E
F
L
L
K
------------------------
V
S
D
R
L
E
I
E
N
R
D
P
P
S
--------
A
L
L
M
K
F
D
A
G
S
D
F
V
I
P
S
G
D
W
T
V
--
K
F
D
K
T
F
M
D
R
-------
K
Y
H
S
S
K
L
M
D
L
L
R
A
L
R
N
K
Y
H
H
F
M
D
L
P
E
D
I
A
E
L
M
G
P
V
P
D
G
F
Y
D
Y
F
T
K
R
F
P
N
L
L
I
G
V
Y
M
I
V
K
E
N
L
S
D
D
Q
I
L
R
E
F
L
Y
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
Fugue
64.69
25%
25
- C1 -
-
5KCV
1
AKT1_HUMAN
A:
[20-452]
-------------------------------------------------------------------------------------------------------
I
V
K
E
G
W
L
H
K
R
G
E
Y
I
T
W
---
R
P
R
Y
F
L
L
K
NDG
T
F
I
G
Y
KERP
A
P
L
N
N
F
S
V
A
Q
C
Q
L
M
K
T
E
RPRPN
T
F
I
I
R
C
LQWT
T
V
I
E
R
T
F
H
V
E
T
P
E
E
R
E
E
W
T
T
A
I
Q
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
-
K
E
K
-
A
-
T
-
G
-
R
Y
Y
A
M
K
-
I
L
K
K
V
L
Q
--
N
------------------
S
-
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
-
R
V--
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
-------------
D
K
D
G
H
I
K
I
T
D
F
G
L
C
P
E
-----------------------
Y
L
A
P
E
V
L
-------------
E
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
--------------
Q
D
H
E
K
L
F
E
L
I
L
M
E
E
--
I
R
F
P
R
T
L
--
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
-----
L
-----
G
G
G
S
E
D
A
K
E
I
M
--
Q
------
H
R
F
F
A
G
I
V
W
------------------------
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
Fugue
62.86
18%
28
- C1 -
-
2ACX
1
GRK6_HUMAN
A:
[14-532]
KARKGKSKK
W
R
Q
M
L
QFPHISQC
E
E
L
R
L
S
LERD
Y
H
S
L
C
ERN
P
I
G
R
L
L
F
R
E
F
C
A
T
R
P
E
L
S
R
C
V
A
F
L
D
G
V
A
E
Y
E
V
TPDDK
R
K
A
C
G
R
N
L
T
Q
N
FLSHT
G
P
D
L
I
P
E
V
P
R
Q
L
V
T
N
C
T
Q
R
L
E
Q
G
P
C
K
DLF
Q
E
L
T
R
L
T
H
------------
E
Y
L
S
V
A
P
F
A
D
Y
L
--
D
S
I
------------------------
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
P
V
T
K
N
T
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
-
Q
V
R
-
A
-
T
-
G
-
K
M
Y
A
C
K
K
L
E
K
K
R
I
K
--
K
--
R
K
G
E
A
M
A
L
N
E
K
Q
I
L
E
K
V
-
N
S
R
F
V
V
S
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
M
-
G
Q
A
G
F
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
-
E
-
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
-------------
D
D
H
G
H
I
R
I
S
D
L
G
L
A
V
H
V
P
-
E
-
G
---
Q
--
T
-
I
K
G
R
V
G
T
V
G
Y
M
A
P
E
V
V
K
N
E
-------------
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
F
---------
Q
Q
R
-
K
K
K
I
K
R
E
E
V
E
R
L
V
K
E
V
P
--
E
E
Y
S
E
R
F
--
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
--
R
LGCRG
G
-----
S
A
R
E
V
K
E
H
P
L
F
--
K
------
K
L
N
F
K
R
L
G
A
------------------------
G
M
L
E
P
P
F
K
P
D
P
Q
A
I
Y
C
E
P
T
D
Q
D
F
Y
Q
K
F
A
T
G
S
V
P
I
P
W
Q
N
E
M
V
E
T
E
C
F
Q
E
L
N
V
F
G
L
D
G
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
62.40
29%
-15
- C1 -
-
3D5U
-
?
A:
[44-304]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
G
K
G
G
F
A
K
C
Y
E
I
-
T
-
D
M
D
-
T
-
K
-
E
V
F
A
G
K
-
V
V
P
K
S
M
L
--
L
--
K
P
H
Q
K
E
K
M
S
T
E
I
A
I
H
K
S
L
D
N
P
H
V
V
G
F
H
G
F
F
E
D
D
D
F
V
Y
V
V
L
E
I
C
R
R
R
S
L
L
E
L
H
K
R
R
K
A
---
V
T
E
P
E
A
R
Y
F
M
R
Q
T
I
Q
G
V
Q
Y
L
H
N
-
N
-
R
V
I
H
R
D
L
K
L
G
N
L
F
L
-------------
N
D
D
M
D
V
K
I
G
D
F
G
L
A
T
K
I
E
F
D
-
G
---
E
--
R
-
K
K
T
L
C
G
T
P
N
Y
I
A
P
E
V
L
C
K
K
-------------
G
H
S
F
E
V
D
I
W
S
L
G
C
I
L
Y
T
L
L
V
G
K
P
P
F
E
T
S
C
L
K
E
T
Y
I
R
I
-
K
K
N
E
---------------
Y
S
V
P
R
H
I
--
N
P
V
A
S
A
L
I
R
R
M
L
H
A
D
P
T
L
--
R
-----
P
-----
S
V
A
E
L
L
T
D
E
F
F
--
T
S
GYAPM
R
L
P
T
S
C
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------