@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LINJ_05_0390: (2018-07-12 )
MSSRSYYSGSGTTAVVPHTISISTAETTPSQAPSSHTEQPSSDQQHESSLHQATASLPMSLNSTMNNKGASAAAAAAAAAPSSHGGDSHSIGAAAKASGSERANWNNPSFAAALRNSSGSINVDGYPPAQAHQQPSHPSLLSHSTDVDDEGDGAQHAAVNEPLEYCGVRLLPGVEQIDFDEGYYVGTIDENGEMAGYGKATWHSGDTYEGEWLNGMMHGKGTYTWADGDYYQGNYVRGRMEGRGEMKDATGLYTGEWADDMRQGYGRMLYAGGNVYEGEWLAGMRHGSGKLVEPAAHVTYEGEFNRNEKEGRGVQTNSDGDVYEGEFARGKPNGRGTYLWADGARYIGMFKDGVKHGDGCEWLANGDWVAGLFVDGEHVDSQSTRHKATVLTPDSSDADGGSEDGAGDGGAGGSRGSIGLSESTAAAVLAPLDAEKLRRIADQVHAPSFSMNVSAAAMRSLRSSLRKNSSSHYQDFSGPGGVTIEEASSPFLRSLAAPQMLLDDSDLEGWTPLKTIGKGSFGAVYTALLRNGRTVCCKVIELGTVESEEEMEKLRNEIALMRRLRHPNCVQYYGSLEDKVQNTLNIFMEYVSGGTLTSFVAKFKSIPLETLRQWVYQMVCGVKYLHECGIVHRDIKGDNVLVSVDGIVKLADFGCSKAIDDVCSATHGCSTMVGTPYWMAPEVIKCEAGGYGVKSDIWSIGCTIVEMLTGKPPWPECNSMWAAVYKIANSTGLPTEIPADIDPELMDLLQRCFERNPKLRPTAADMLSHPFLAKVTEGVASPLEKSGRK
Atome Classification :
(27 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520-......-.530........-540....-----...550-........560..-.....570.......580.......590.......600------...----....----.--610...-....620.......630.......640..-.---....650..-.....660.......670.......680.....-----.--.690-.........700.......-710.......720.......730-...--.....740.......750.......--760.......770------.......780.......-----------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MSSR
S
Y
YSGSG
T
T
A
V
V
P
H
T
I
S
I
STAETTPSQAPSSHTEQPSS
D
Q
Q
H
E
S
S
L
H
Q
A
T
ASLPMSLNSTMNNKGA
S
A
A
A
A
A
AAAAPSSHGGDSHSIGAAAKASGSERANWNNP
S
F
A
A
A
LRNSSG
S
I
NVDGYPPAQAHQQPSHPSLLSHSTDVDDEGDGAQHAAVN
E
P
L
E
Y
CGVRLLPGVEQIDFDE
G
Y
Y
V
G
T
IDENGEMAGYGKATWHSGDTYE
G
E
W
LN
G
M
MHGK
G
T
Y
T
WADGDYYQG
N
Y
V
R
G
RMEGRGEMKDATGLYTG
E
W
A
D
D
M
R
Q
GYG
R
M
L
YAGGNVYEG
E
W
L
A
G
MRHGSG
K
L
VEP
A
A
H
V
T
YEGEFNRNEKEGRGVQTNSDGDVYEGEFARGKPNGR
G
T
Y
L
WADG
A
R
Y
I
G
M
FKDGVKHGDGC
E
W
LANG
D
W
V
A
G
L
F
VDGEHVDSQSTR
H
K
A
T
V
LTPDSSDADGGSEDGAGDGGAGGSRGSIGLSEST
A
A
A
V
LAPL
D
A
E
K
L
R
R
I
A
D
Q
VHAPSFSM
N
V
S
A
A
A
M
R
S
L
R
S
S
L
RKNSSSHYQDFSGPG
G
V
T
IEEAS
S
P
F
L
R
S
LAA
P
Q
MLLDDSDLEGWTP
L
K
T
IGKG
S
F
G
-
A
V
Y
T
A
L
-
L
R-NG
R
T
V
C
C
K
V
-
I
ELGTVE-----
S
E
E
E
M
--
E
K
L
R
N
E
I
A
L
M
R
R
L-RHP
N
C
V
Q
Y
Y
G
S
L
E
D
K
V
Q
N
T
L
N
I
F
M
E
Y
VSGG
T
L
T
S
F
V
A
-------
K
F
K----SI
P
L
----
E
--
T
L
R
Q
W
V
-
Y
Q
M
V
C
G
V
K
Y
L
H
ECGI
V
H
RDIKG
D
N
V
L
V
SV-D---
G
I
V
K
L
A
DFG-
C
S
K
A
I
D
D
V
CSATHGCSTMVGTPYWMA
P
E
V
I
K
CE-----A--GG---YGVK
S
D
I
W
S
I
G
C
T
I
V
E
M
L
T-GKPPWP
E
C
N
S
M
W
A
A
V
Y
K
I
ANS-T-GLP--TEIPADI
D
P
E
L
M
D
L
L
Q
R
C
F
ERNPKL--RP
T
A
A
D
M
LSH
P
F
L
------
A
K
V
T
E
G
V
A
S
P
L
E
KSGRK-----------------------------------------------------------------------------------------------------------
39
HHSearch
75.19
36%
-53
- C1 -
-
4XBR
1
INKA1_HUMAN (first)
A:
[94-352]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
-
I
V
C
I
A
T
-
V
R
S
S
G
K
L
V
A
V
K
K
-
M
D
L
R
K
--------
Q
Q
R
R
--
E
L
L
F
N
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
--
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
-------
H
T
-----
R
M
N
E
----
E
--
Q
I
A
A
V
C
-
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
-
D
---
G
R
V
K
L
S
D
F
G
-
F
C
A
Q
V
S
K
E
V
P
---
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
S
R
L
---------
P
---
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
-
G
E
P
P
Y
F
N
E
P
P
L
K
-
A
M
K
M
I
R
D
N
-
L
-
P
P
R
--
L
K
N
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
--
R
A
T
A
A
E
L
L
K
H
P
F
L
------
A
K
A
G
P
-----------------------------------------------------------------------------------------------------------------------
41
HHSearch
71.13
35%
-51
- C1 -
-
5J5T
1
M4K3_HUMAN
A:
[4-268]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
F
E
L
I
Q
R
I
G
S
G
T
Y
G
-
D
V
Y
K
A
R
-
N
V
N
T
G
E
L
A
A
I
K
V
-
I
K
L
E
P
--------
G
E
D
F
--
A
V
V
Q
Q
E
I
I
M
M
K
D
C
-
K
H
P
N
I
V
A
Y
F
G
S
Y
L
R
R
--
D
K
L
W
I
C
M
E
F
C
G
G
G
S
L
Q
D
I
Y
H
-------
V
T
G
----
P
L
S
E
----
L
--
Q
I
A
Y
V
S
-
R
E
T
L
Q
G
L
Y
Y
L
H
S
K
G
K
M
H
R
D
I
K
G
A
N
I
L
L
T
D
-
N
---
G
H
V
K
L
A
D
F
G
-
V
S
A
Q
I
T
A
T
I
A
------
A
F
I
G
T
P
Y
W
M
A
P
E
V
A
A
V
E
R----
K
--
G
G
---
Y
N
Q
L
C
D
L
W
A
V
G
I
T
A
I
E
L
A
E
-
L
Q
P
P
M
F
D
L
H
P
M
R
-
A
L
F
L
M
T
K
S
-
N
-
F
Q
P
P
K
L
K
D
K
M
K
W
S
N
S
F
H
H
F
V
K
M
A
L
T
K
N
P
K
K
--
R
P
T
A
E
K
L
L
Q
H
P
F
V
------
T
Q
H
-------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
70.31
34%
-23
- C1 -
-
4APC
-
NEK1_HUMAN
A:
[23-290]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
K
Y
V
R
L
Q
K
I
------K
A
I
L
V
K
S
-
T
E
-
D
G
R
Q
Y
V
I
K
E
-
I
N
I
S
R
M
S
-----
S
K
E
R
---
E
E
S
R
R
E
V
A
V
L
A
N
M
-
K
H
P
N
I
V
Q
Y
R
E
S
F
E
E
--
N
G
S
L
Y
I
V
M
D
Y
C
E
G
G
D
L
F
K
R
I
N
-------
A
Q
K
----
G
V
L
F
----
Q
E
D
Q
I
L
D
W
F
-
V
Q
I
C
L
A
L
K
H
V
H
D
R
K
I
L
H
R
D
I
K
S
Q
N
I
F
L
T
K
-
D
---
G
T
V
Q
L
G
D
F
G
-
I
A
R
V
L
N
S
T
V
E
L
A
R
A
C
---
I
G
T
P
Y
Y
L
S
P
E
I
--
C
E
-----
N
--
K
P
---
Y
N
N
K
S
D
I
W
A
L
G
C
V
L
Y
E
L
C
T
-
L
K
H
A
F
-
E
A
G
S
M
K
N
L
V
L
K
I
I
S
G
-
S
-
F
P
P
--
V
S
L
H
Y
S
Y
D
--
L
R
S
L
V
S
Q
L
F
K
R
N
P
R
D
--
R
P
S
V
N
S
I
L
E
K
G
F
I
------
A
K
R
I
E
K
F
L
S
P
------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
69.83
34%
-24
- C1 -
-
4B9D
1
NEK1_HUMAN
A:
[23-290]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
K
Y
V
R
L
Q
K
I
------K
A
I
L
V
K
S
-
T
E
-
D
G
R
Q
Y
V
I
K
E
-
I
N
I
S
R
M
S
-----
S
K
E
R
---
E
E
S
R
R
E
V
A
V
L
A
N
M
-
K
H
P
N
I
V
Q
Y
R
E
S
F
E
E
--
N
G
S
L
Y
I
V
M
D
Y
C
E
G
G
D
L
F
K
R
I
N
-------
A
Q
K
----
G
V
L
F
----
Q
E
D
Q
I
L
D
W
F
-
V
Q
I
C
L
A
L
K
H
V
H
D
R
K
I
L
H
R
D
I
K
S
Q
N
I
F
L
T
K
-
D
---
G
T
V
Q
L
G
D
F
G
-
I
A
R
V
L
N
S
T
V
E
L
A
R
A
C
---
I
G
T
P
Y
Y
L
S
P
E
I
--
C
E
-----
N
--
K
P
---
Y
N
N
K
S
D
I
W
A
L
G
C
V
L
Y
E
L
C
T
-
L
K
H
A
F
-
E
A
G
S
M
K
N
L
V
L
K
I
I
S
G
-
S
-
F
P
P
--
V
S
L
H
Y
S
Y
D
--
L
R
S
L
V
S
Q
L
F
K
R
N
P
R
D
--
R
P
S
V
N
S
I
L
E
K
G
F
I
------
A
K
R
I
E
K
F
L
S
P
------------------------------------------------------------------------------------------------------------------
23
HHSearch
69.41
26%
-23
- C1 -
-
2Y7J
1
PHKG2_HUMAN
C:
[92-365]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
Y
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
-
V
V
R
R
C
V
-
H
R
A
T
G
H
E
F
A
V
K
I
-
M
E
V
T
A
E
R
LSPEQ
L
E
E
V
R
--
E
A
T
R
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
--
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
-------
E
K
V
----
A
L
S
E
----
K
--
E
T
R
S
I
M
-
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
D
D
-
N
---
M
Q
I
R
L
S
D
F
G
-
F
S
C
H
L
E
P
G
E
----
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
C
S
MDET-
H
--
P
G
---
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
-
G
S
P
P
F
W
H
R
R
Q
I
L
-
M
L
R
M
I
M
E
G
-
Q
Y
Q
F
S
--
S
P
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
--
R
L
T
A
E
Q
A
L
Q
H
P
F
F
------
E
R
--------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
67.95
37%
-30
- C1 -
-
6FD3
3
PAK3_HUMAN
A:
[24-275]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
R
F
E
K
I
G
Q
G
A
S
G
-
T
V
Y
T
A
L
D
I
A
-
T
G
Q
E
V
A
I
K
Q
-
M
N
L
---
Q
-----
Q
Q
P
K
K
--
E
L
I
I
N
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
--
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
M
D
E
G
Q
I
A
----
A
V
C
R
----
E
--
C
L
Q
---------
A
L
D
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
-
D
---
G
S
V
K
L
T
D
F
G
F
C
A
Q
----
I
T
P
E
Q
S
K
R
S
-
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
K
-----
A
-------
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
V
E
-
G
E
P
P
Y
L
N
E
N
P
L
-
R
A
L
Y
L
I
A
T
N
-
G
-
T
P
E
--
L
Q
N
P
E
R
L
S
A
V
F
R
D
F
L
N
R
C
L
E
M
D
V
D
R
--
R
G
S
A
K
E
L
L
Q
H
P
F
L
----------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
67.62
26%
-23
- C1 -
-
2Y7J
1
PHKG2_HUMAN
D:
[92-365]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
Y
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
-
V
V
R
R
C
V
-
H
R
A
T
G
H
E
F
A
V
K
I
-
M
E
V
---
R
LSPEQ
L
E
E
V
R
--
E
A
T
R
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
--
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
-------
E
K
V
----
A
L
S
E
----
K
--
E
T
R
S
I
M
-
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
D
D
-
N
---
M
Q
I
R
L
S
D
F
G
-
F
S
C
H
L
E
P
G
E
----
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
C
S
MDET-
H
--
P
G
---
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
-
G
S
P
P
F
W
H
R
R
Q
I
L
-
M
L
R
M
I
M
E
G
-
Q
Y
Q
F
S
--
S
P
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
--
R
L
T
A
E
Q
A
L
Q
H
P
F
F
------
E
R
--------------------------------------------------------------------------------------------------------------------------
40
HHSearch
67.32
28%
-42
- C1 -
-
4WOT
1
ROCK2_HUMAN
B:
[69-339]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
Y
D
V
V
K
V
I
G
R
G
A
F
G
-
E
V
Q
L
V
R
-
H
K
A
S
Q
K
V
Y
A
M
K
L
-
L
S
K
F
E
M
I
-----
K
R
S
D
S
--
A
F
F
W
E
E
R
D
I
M
A
F
A
-
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
--
R
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
-------
N
Y
-----
D
V
P
E
----
K
--
W
A
K
F
Y
T
-
A
E
V
V
L
A
L
D
A
I
H
S
M
G
L
I
H
R
D
V
K
P
D
N
M
L
L
D
K
-
H
---
G
H
L
K
L
A
D
F
G
-
T
C
M
K
M
D
E
T
G
M
--
V
H
C
D
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
-----
G
GD
G
F
---
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
-
G
D
T
P
F
Y
A
D
S
L
V
-
G
T
Y
S
K
I
M
D
H
-
K
N
S
L
C
--
F
P
E
D
A
E
I
S
K
H
A
K
N
L
I
C
A
F
L
T
D
R
E
V
R
LG
R
N
G
V
E
E
I
R
Q
H
P
F
F
------
K
N
D
Q
------------------------------------------------------------------------------------------------------------------------
45
Fugue
65.64
26%
-32
- C1 -
-
2RIO
1
IRE1_YEAST
A:
[8-434]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
F
E
Q
S
L
K
N
L
V
V
S
E
K
I
L
G
Y
G
S
S
G
-
T
V
V
F
Q
G
-
S
F
-
Q
G
R
P
V
A
V
K
R
-
M
L
-----------
I
D
F
C
--
D
I
A
L
M
E
I
K
L
L
T
E
S
D
D
H
P
N
V
I
R
Y
Y
C
S
E
T
T
D
--
R
F
L
Y
I
A
L
E
L
C
N
L
N
-
L
Q
D
L
V
E
-------
S
K
Y
---------------
N
P
I
S
L
L
-
R
Q
I
A
S
G
V
A
H
L
H
S
L
K
I
I
H
R
D
L
K
P
Q
N
I
L
V
S
T
-
S
---
S
R
F
T
A
D
Q
Q
T
-
G
A
E
N
L
R
I
L
I
S
D
F
G
L
C
K
K
L
D
S
T
S
G
W
R
A
P
E
L
L
E
E
S
NNLQT
K
--
R
R
---
L
T
R
S
I
D
I
F
S
M
G
C
V
F
Y
Y
I
L
S
K
G
K
H
P
F
G
D
K
Y
S
R
E
S
N
I
I
R
G
I
F
S
L
D
-
E
M
K
--
C
L
H
D
R
S
L
I
A
E
A
T
D
L
I
S
Q
M
I
D
H
D
P
L
K
--
R
P
T
A
M
K
V
L
R
H
P
L
F
WP
K
S
K
K
L
E
F
L
L
K
V
S
D
R
L
E
I
E
N
R
D
PPS
A
L
L
M
K
F
D
A
G
S
DFVIPSGDWTVKFDKTFMDRKYHSSK
L
M
D
L
L
R
A
L
R
N
K
Y
H
H
F
MDLP
E
D
I
A
E
L
M
GPVP
D
G
F
Y
D
Y
F
T
K
R
FPN
L
L
I
G
V
Y
M
I
V
K
E
NLSDD
Q
I
L
R
E
F
L
YS
17
PsiBlast_PDB
65.17
36%
-28
- C1 -
-
6B16
1
PAK1_HUMAN
A:
[23-280]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
R
F
E
K
I
G
Q
G
A
S
G
-
T
V
Y
T
A
M
D
V
A
-
T
G
Q
E
V
A
I
K
--------------
Q
Q
P
K
K
--
E
L
I
I
N
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
--
L
--
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
M
D
E
G
Q
I
A
----
A
V
C
R
----
E
--
C
L
Q
---------
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
-
D
---
G
S
V
K
L
T
D
F
G
-
F
C
A
Q
I
T
P
E
Q
S
K
R
---
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
K
-----
A
-------
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
-
G
E
P
P
Y
L
N
E
N
P
L
-
R
A
L
Y
L
I
A
T
N
-
G
-
T
P
E
--
L
Q
N
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
--
R
G
S
A
K
E
L
L
Q
H
Q
F
L
------
K
-----
I
A
K
P
L
-----------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
64.89
36%
-40
- C1 -
-
4ZJJ
1
PAK1_HUMAN
A:
[24-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
R
F
E
K
I
G
Q
G
A
S
G
-
T
V
Y
T
A
M
D
V
A
-
T
G
Q
E
V
A
I
K
Q
-
M
N
L
---
Q
---------
K
--
E
L
I
I
N
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
--
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
M
D
E
G
Q
I
A
----
A
V
C
R
----
E
--
C
L
Q
---------
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
-
D
---
G
S
V
K
L
T
D
F
G
F
C
A
Q
----
I
T
-------
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
K
-----
A
-------
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
-
G
E
P
P
Y
L
N
E
N
P
L
-
R
A
L
Y
L
I
A
T
N
-
G
-
T
P
E
--
L
Q
N
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
--
R
G
S
A
K
E
L
L
Q
H
Q
F
L
------
K
-----
I
A
K
P
L
-----------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
64.50
36%
-35
- C1 -
-
4ZJI
1
PAK1_HUMAN
A:
[24-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
R
F
E
K
I
G
Q
G
A
S
G
-
T
V
Y
T
A
M
D
V
A
-
T
G
Q
E
V
A
I
K
Q
-
M
N
L
-------------
K
--
E
L
I
I
N
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
--
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
M
D
E
G
Q
I
A
----
A
V
C
R
----
E
--
C
L
Q
---------
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
-
D
---
G
S
V
K
L
T
D
F
G
F
C
A
Q
----
I
T
P
------
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
K
-----
A
-------
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
-
G
E
P
P
Y
L
N
E
N
P
L
-
R
A
L
Y
L
I
A
T
N
-
G
-
T
P
E
--
L
Q
N
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
--
R
G
S
A
K
E
L
L
Q
H
Q
F
L
------
K
-----
I
A
K
P
L
-----------------------------------------------------------------------------------------------------------------
38
HHSearch
63.64
26%
-43
- C1 -
-
3C0I
1
CSKP_HUMAN
A:
[24-294]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
-
V
V
R
R
C
I
-
N
R
E
T
G
Q
Q
F
A
V
K
I
-
V
D
V
A
K
F
T
S
S---
P
G
L
S
T
--
E
D
L
K
R
E
A
S
I
C
H
M
L
-
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
--
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
-------
K
R
A
D
A
G
F
V
Y
S
E
----
A
--
V
A
S
H
Y
M
-
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
-
K
ENS
A
P
V
K
L
G
G
F
G
-
V
A
I
Q
L
G
E
S
G
L
---
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
R
E
---------
P
---
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
-
G
C
L
P
F
Y
G
T
K
E
R
--
L
F
E
G
I
I
K
G
K
Y
-
K
M
N
--
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
--
R
I
T
V
Y
E
A
L
N
H
P
W
L
------
K
E
R
D
------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
63.55
34%
-53
- C1 -
-
4USF
1
SLK_HUMAN
A:
[18-276]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
I
G
E
L
G
D
G
A
F
G
-
K
V
Y
K
A
---
Q
-
N
K
E
T
S
V
L
A
A
-
A
K
V
I
D
T
K
-----
S
E
E
E
L
--
E
D
Y
M
V
E
I
D
I
L
A
S
C
-
D
H
P
N
I
V
K
L
L
D
A
F
--
Y
Y
E
N
N
L
W
I
L
I
E
F
C
A
G
G
A
V
D
A
V
M
L
-------
E
L
E
----
R
P
L
T
----
E
--
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
K
I
I
H
R
D
L
K
A
G
N
I
L
F
T
L
-
D
---
G
D
I
K
L
A
D
F
G
-
V
S
A
K
----------------
T
P
Y
W
M
A
P
E
V
V
M
C
E
----------RP-
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
-
I
E
P
P
H
H
E
L
N
P
M
-
R
V
L
L
K
I
A
K
S
-
E
-
P
P
T
--
L
A
Q
P
S
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
--
R
W
T
T
S
Q
L
L
Q
H
P
F
V
----------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
62.91
34%
-54
- C1 -
-
2JFM
2
SLK_HUMAN
A:
[39-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
I
G
E
L
G
D
G
A
F
G
-
K
V
Y
K
A
---
Q
-
N
K
E
T
S
V
L
A
A
-
A
K
V
I
D
T
K
-----
S
E
E
E
L
--
E
D
Y
M
V
E
I
D
I
L
A
S
C
-
D
H
P
N
I
V
K
L
L
D
A
F
--
Y
Y
E
N
N
L
W
I
L
I
E
F
C
A
G
G
A
V
D
A
V
M
L
-------
E
L
E
----
R
P
L
T
----
E
--
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
K
I
I
H
R
D
L
K
A
G
N
I
L
F
T
L
-
D
---
G
D
I
K
L
A
D
F
G
-
V
S
A
K
---
N
T
R
T
I
Q
R
R
D
S
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
-----
T
--
S
K
DRP
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
-
I
E
P
P
H
H
E
L
N
P
M
-
R
V
L
L
K
I
A
K
S
-
E
-
P
P
T
--
L
A
Q
P
S
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
--
R
W
T
T
S
Q
L
L
Q
H
P
F
V
----------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
62.83
34%
-55
- C1 -
-
2J51
5
SLK_HUMAN
A:
[39-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
I
G
E
L
G
D
G
A
F
G
-
K
V
Y
K
A
---
Q
-
N
K
E
T
S
V
L
A
A
-
A
K
V
I
D
T
K
-----
S
E
E
E
L
--
E
D
Y
M
V
E
I
D
I
L
A
S
C
-
D
H
P
N
I
V
K
L
L
D
A
F
--
Y
Y
E
N
N
L
W
I
L
I
E
F
C
A
G
G
A
V
D
A
V
M
L
-------
E
L
E
----
R
P
L
T
----
E
--
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
K
I
I
H
R
D
L
K
A
G
N
I
L
F
T
L
-
D
---
G
D
I
K
L
A
D
F
G
-
V
S
A
K
---
N
T
R
T
I
Q
R
R
D
S
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
-----
T
--
S
K
DRP
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
-
I
E
P
P
H
H
E
L
N
P
M
-
R
V
L
L
K
I
A
K
S
-
E
-
P
P
T
--
L
A
Q
P
S
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
--
R
W
T
T
S
Q
L
L
Q
H
P
F
V
----------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
61.83
39%
-0
- C1 -
-
5VIL
6
M3K5_HUMAN
A:
[27-280]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
K
G
T
Y
G
-
I
V
Y
A
-------
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
-----
E
R
D
S
R
Y
S
Q
P
L
H
E
E
I
A
L
H
K
H
L
-
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
--
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
--------
R
S
K
----
W
G
P
L
KDN
E
Q
--
T
I
G
F
Y
T
-
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
---
G
V
L
K
I
S
D
F
G
-
T
S
K
R
L
A
G
I
N
P
C
T
E
---
T
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
G
-----
P
--
R
G
---
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
-
G
K
P
P
F
Y
E
L
G
E
P
Q
A
A
M
F
K
V
G
M
F
-
K
-
V
H
P
---
E
I
P
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
--
R
A
C
A
N
D
L
L
V
D
E
F
L
----------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
61.59
26%
-42
- C1 -
-
3C0G
1
CSKP_HUMAN
B:
[24-294]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
-
V
V
R
R
C
I
-
N
R
E
T
G
Q
Q
F
A
V
K
I
-
V
D
V
A
K
F
T
S
S---
P
G
L
S
T
--
E
D
L
K
R
E
A
S
I
C
H
M
L
-
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
--
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
-------
K
R
A
D
A
G
F
V
Y
S
E
----
A
--
V
A
S
H
Y
M
-
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
-
K
ENS
A
P
V
K
L
G
G
F
G
-
V
A
I
Q
L
G
E
S
G
L
---
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
R
E
---------
P
---
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
-
G
C
L
P
F
Y
G
T
K
E
R
--
L
F
E
G
I
I
K
G
K
Y
-
K
M
N
--
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
--
R
I
T
V
Y
E
A
L
N
H
P
W
L
------
K
E
R
D
------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
61.45
36%
-26
- C1 -
-
4ZY6
1
PAK1_HUMAN
A:
[23-280]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
R
F
E
K
I
G
Q
G
A
S
G
-
T
V
Y
T
A
M
D
V
A
-
T
G
Q
E
V
A
I
K
---------------
Q
P
K
K
--
E
L
I
I
N
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
--
L
V
--
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
C
M
D
E
G
Q
I
A
----
A
V
C
R
----
E
--
C
L
Q
---------
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
-
D
---
G
S
V
K
L
T
D
F
G
-
F
C
A
Q
I
T
P
E
Q
S
K
R
---
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
K
-----
A
-------
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
-
G
E
P
P
Y
L
N
E
N
P
L
-
R
A
L
Y
L
I
A
T
N
-
G
-
T
P
E
--
L
Q
N
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
--
R
G
S
A
K
E
L
L
Q
H
Q
F
L
------
K
-----
I
A
K
P
L
-----------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
60.51
36%
-26
- C1 -
-
4ZY4
1
PAK1_HUMAN
A:
[23-280]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
R
F
E
K
I
G
Q
G
A
S
G
-
T
V
Y
T
A
M
D
V
A
-
T
G
Q
E
V
A
I
K
--------------
Q
Q
P
K
K
--
E
L
I
I
N
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
--
L
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
T
CMD
E
G
Q
I
A
----
A
V
C
R
----
E
--
C
L
Q
---------
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
-
D
---
G
S
V
K
L
T
D
F
G
-
F
C
A
Q
I
T
P
E
Q
S
K
R
---
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
T
R
K
-----
A
-------
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
-
G
E
P
P
Y
L
N
E
N
P
L
-
R
A
L
Y
L
I
A
T
N
-
G
-
T
P
E
--
L
Q
N
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
--
R
G
S
A
K
E
L
L
Q
H
Q
F
L
------
K
-----
I
A
K
P
L
-----------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
60.45
39%
2
- C1 -
-
5VIO
2
M3K5_HUMAN
A:
[27-280]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
K
G
T
Y
G
-
I
V
Y
A
-------
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
-----
E
R
D
S
R
Y
S
Q
P
L
H
E
E
I
A
L
H
K
H
L
-
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
--
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
--------
R
S
K
----
W
G
P
L
KDN
E
Q
--
T
I
G
F
Y
T
-
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
---
G
V
L
K
I
S
D
F
G
-
T
S
K
R
L
A
G
I
N
P
C
T
E
---
T
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
G
-----
P
--
R
G
---
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
-
G
K
P
P
F
Y
E
L
G
E
P
Q
A
A
M
F
K
V
G
M
F
-
K
-
V
H
P
---
E
I
P
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
--
R
A
C
A
N
D
L
L
V
D
E
F
L
----------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
59.70
39%
-12
- C1 -
-
5V24
1
M3K5_HUMAN
A:
[16-269]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
K
G
T
Y
G
-
I
V
Y
A
-------
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
-----
E
R
D
S
----
P
L
H
E
E
I
A
L
H
K
H
L
-
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
--
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
--------
R
S
K
----
W
G
P
L
KDN
E
Q
--
T
I
G
F
Y
T
-
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
---
G
V
L
K
I
S
D
F
G
-
T
S
K
R
L
------------
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
---------------
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
-
G
K
P
P
F
Y
E
--
E
P
Q
A
A
M
F
K
V
G
M
F
-
K
-
V
H
P
---
E
I
P
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
--
R
A
C
A
N
D
L
L
V
D
E
F
L
----------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
58.03
39%
-2
- C1 -
-
4BIE
2
M3K5_HUMAN
A:
[26-279]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
K
G
T
Y
G
-
I
V
Y
A
-------
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
-----
E
--------
L
H
E
E
I
A
L
H
K
H
L
-
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
--
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
--------
R
S
K
----
W
G
P
L
KDN
E
Q
--
T
I
G
F
Y
T
-
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
---
G
V
L
K
I
S
D
F
G
-
T
S
K
R
L
A
G
---------
E
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
G
-----
P
--
R
G
---
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
-
G
K
P
P
F
Y
E
L
G
E
P
Q
A
A
M
F
K
V
G
M
F
-
K
-
V
H
P
---
E
I
P
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
--
R
A
C
A
N
D
L
L
V
D
E
F
L
----------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
57.89
39%
7
- C1 -
-
2CLQ
1
M3K5_HUMAN
A:
[29-282]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
K
G
T
Y
G
-
I
V
Y
A
-------
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
-----
E
R
D
S
---
Q
P
L
H
E
E
I
A
L
H
K
H
L
-
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
--
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
--------
R
S
K
----
W
G
P
L
KDN
E
Q
--
T
I
G
F
Y
T
-
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
---
G
V
L
K
I
S
D
F
G
-
T
S
K
R
L
A
G
-----
E
---
T
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
G
-----
P
--
R
G
---
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
-
G
K
P
P
F
Y
E
L
G
E
P
Q
A
A
M
F
K
V
G
M
F
-
K
-
V
H
P
---
E
I
P
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
--
R
A
C
A
N
D
L
L
V
D
E
F
L
----------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
57.65
39%
-5
- C1 -
-
4BF2
2
M3K5_HUMAN
A:
[42-295]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
K
G
T
Y
G
-
I
V
Y
A
-------
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
-----
E
----------
E
E
I
A
L
H
K
H
L
-
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
--
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
--------
R
S
K
----
W
G
P
L
KDN
E
Q
--
T
I
G
F
Y
T
-
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
---
G
V
L
K
I
S
D
F
G
-
T
S
K
R
L
A
------
E
---
E
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
G
-----
P
--
R
G
---
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
-
G
K
P
P
F
Y
E
L
G
E
P
Q
A
A
M
F
K
V
G
M
F
-
K
-
V
H
P
---
E
I
P
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
--
R
A
C
A
N
D
L
L
V
D
E
F
L
----------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
57.15
39%
3
- C1 -
-
4BIC
2
M3K5_HUMAN
A:
[26-279]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
K
G
T
Y
G
-
I
V
Y
A
-------
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
-----
E
----S-
Q
P
L
H
E
E
I
A
L
H
K
H
L
-
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
--
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
--------
R
S
K
----
W
G
P
L
KDN
E
Q
--
T
I
G
F
Y
T
-
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
---
G
V
L
K
I
S
D
F
G
-
T
S
K
R
L
A
G
---------
E
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
K
G
-----
P
--
R
G
---
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
-
G
K
P
P
F
Y
E
L
G
E
P
Q
A
A
M
F
K
V
G
M
F
-
K
-
V
H
P
---
E
I
P
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
--
R
A
C
A
N
D
L
L
V
D
E
F
L
----------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
56.94
39%
-10
- C1 -
-
5UOR
1
M3K5_HUMAN
A:
[16-269]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
K
G
T
Y
G
-
I
V
Y
A
-------
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
-----
E
R
D
S
R
Y
S
Q
P
L
H
E
E
I
A
L
H
K
H
L
-
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
--
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
--------
R
S
K
----
W
G
P
L
KDN
E
Q
--
T
I
G
F
Y
T
-
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
---
G
V
L
K
I
S
D
F
G
-
T
S
K
R
L
------------
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
---------------
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
-
G
K
P
P
F
Y
E
------
A
M
F
K
V
G
M
F
-
K
-
V
H
P
---
E
I
P
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
--
R
A
C
A
N
D
L
L
V
D
E
F
L
----------------------------------------------------------------------------------------------------------------------------------