@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LINJ_13_1380: (2018-07-12 )
MMFNEAAVPFIQTARDNGLLFGGSNVPAMIDYTSEHRKSYHVRGSVFEVAPHFEVLNGIGYGAYGVVCAAVDLRLVASSVYYNEAMRIIEEGGRIVTRQRRGHDAPVYFRTRAVLDEAGRGGPVRVPHLYSEPFKRRVLACGGVSPFVAIKKVTKVFDDLVDGRRILREIKLLRYLQGHPNIVRLMEVGRPHVPTGASSSAAFDDIYLVTDLMDTDLAALLKSSQEIEMDQFRFIAYQLMKVLVYVHSSGVIHRDLKPGNILLNGNCDMKLCDFGLSRGGVPAWPHESTLTAVATAAESSAKELEDWGLFCWSSSAVRGASSAPHAAKQPPLYSLTDYVVTRYYRAPELLIMGRYNHAIDMWSAGCILAEMLLRRPLFTGANYLSQLALILETPGLRGVPQTPEQVAALFEGGEEGKHFINDILFRKTARGRDSLTLSNQVHSQVLFHSTLFGFNVDIPISLGILIAKLLSFDPRKRPTAVEALRDPFFRPLYDSRDEILRCPASDPSVEREEIDDIAAYQKAHPCVVVDESPVFTWEFDHRITSAQALRSLFEEECQISRDVQQQIERQQRPR
Atome Classification :
(27 SA)
.........10........20........30........40........50.-.......60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.-..-.....360.......370.......380......-----------------.390.......400.......410.......420.......------430.......440.......450.......460..-.....470.......480.......490.......500.......510.......520.......530.......540........550.......560.......570..
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MMFNEAAV
P
F
I
QTARDN
G
L
L
FGGSNV
P
A
M
I
DY
T
S
E
H
R
K
S
Y
H
VRG
S
V
F
E
VA
P
H
-
F
E
V
L
N
GIG
Y
G
A
Y
G
V
V
C
A
A
V
D
L
R
L
V
A
S
S
V
Y
Y
N
E
A
M
R
I
I
EEG
G
R
I
V
T
R
QRRGHDA
P
V
Y
F
R
T
R
A
V
L
DEAGRGGPVRVP
H
L
Y
SE
P
F
K
R
R
V
L
ACGGV
S
P
F
V
A
I
K
K
V
T
K
V
F
D
D
L
V
D
G
R
R
I
L
R
E
I
K
L
L
R
Y
L
QGHP
N
I
V
R
L
M
EVGRPHVPTGASSSAAF
D
D
I
Y
L
V
T
D
LM
D
T
D
L
A
A
L
L
KSSQEI
E
M
D
Q
F
R
F
I
A
Y
Q
L
M
K
V
L
V
Y
VHSS
G
V
I
H
RDLKPG
N
I
L
LNGNC
D
M
K
L
C
DFGLSRGGVPAWPHES
T
L
T
A
V
A
T
A
A
E
S
S
A
K
E
L
E
D
W
G
L
F
C
WSSSAVRGASSAPHAAKQPP
L
Y
S
L
T
D
Y
V
V
T
R
YYRAP
E
L
L
I
-
M
-GR-YNH
A
I
D
M
WS
A
G
C
I
L
A
E
M
L
LRRPLF
T
G
A
N
Y
L
S
Q
L
A
-----------------
L
I
L
ETPGLRGVPQ
T
P
E
Q
V
A
A
L
FEGGE
E
G
K
H
F
I
N
D
I
L
F
R
KTA------RGRD
S
L
T
L
S
N
Q
V
H
S
Q
V
L
F
H
S
T
L
F
G
F
NVDIPI
S
L
G
I
-
L
I
A
K
L
LSFDPRKR
P
T
A
V
E
A
L
RDPFF
R
P
L
YDS
R
D
E
I
LRCPASDPSV
E
R
E
E
I
D
D
I
A
A
Y
QKAH
P
C
V
V
VDES
P
V
F
T
W
EFDH-RI
T
S
A
Q
A
L
R
S
L
F
E
E
E
C
Q
I
S
R
D
V
Q
Q
Q
I
E
R
QQRPR
21
HHSearch
86.48
39%
-91
* C1 *
-
5BYZ
7
MK07_HUMAN
A:
[3-345]
-----------------------------------------------
D
V
G
D
E
-
Y
E
I
I
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
R
R
L
------------------------------------------------------------------
T
G
---
Q
Q
V
A
I
K
K
I
P
N
A
F
D
V
V
T
N
A
K
R
T
L
R
E
L
K
I
L
K
H
F
K
-
H
D
N
I
I
A
I
K
D
I
L
R
P
T
V
P
-----
Y
G
E
F
K
S
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
H
S
S
Q
P
L
T
L
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
E
N
C
E
L
K
I
G
D
F
G
M
A
R
G
L
C
T
S
P
A
E
--------------------------------------------
H
Q
Y
F
M
T
E
Y
V
A
T
R
W
Y
R
A
P
E
L
M
L
-
S
L
H
E
-
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
R
R
Q
L
F
P
G
K
N
Y
V
H
Q
L
Q
-----------------
L
I
M
M
V
L
G
T
---
P
S
-
P
A
V
I
Q
A
--
V
G
A
E
R
V
R
A
Y
I
Q
S
L
P
P
R
Q
P
V
------------------
P
----
W
E
-
T
V
Y
---
P
G
A
D
R
Q
A
L
S
-
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
Y
H
D
P
D
D
E
P
D
C
A
P
P
------------------------------
F
D
F
A
F
D
R
-
E
A
L
T
R
E
R
I
K
E
A
I
V
A
E
I
E
D
F
H
A
R
R
----------
26
HHSearch
85.46
39%
-91
- C1 -
-
4ZZN
1
MK01_HUMAN
A:
[4-345]
-----------------------------------------
V
R
G
Q
V
F
D
V
G
P
R
-
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
N
L
------------------------------------------------------------------
N
K
---
V
R
V
A
I
K
K
I
S
P
F
E
-
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
-
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
------
I
E
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
K
T
-
Q
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
V
A
D
P
D
H
D
---------------------------------------------
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
-
N
S
K
G
-
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
Q
L
N
-----------------
H
I
L
G
I
L
G
S
---
P
S
-
Q
E
D
L
N
C
--
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
H
K
N
K
------------------
V
P
----
W
N
-
R
L
F
P
---
N
A
D
S
K
A
L
D
-
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
E
A
P
------------------------------
F
-------
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
Q
-------------
33
HHSearch
84.89
39%
-88
- C1 -
-
4XNE
1
MK01_RAT
A:
[5-346]
------------------------------------------
R
G
Q
V
F
D
V
G
P
R
-
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
N
L
------------------------------------------------------------------
N
K
---
V
R
V
A
I
K
K
I
S
P
F
E
-
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
-
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
------
I
E
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
K
T
-
Q
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
V
A
D
P
D
H
D
---------------------------------------------
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
-
N
S
K
G
-
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
Q
L
N
-----------------
H
I
L
G
I
L
G
S
---
P
S
-
Q
E
D
L
N
C
--
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
H
K
N
K
V
------------------
P
----
W
N
-
R
L
F
---
P
N
A
D
S
K
A
L
D
-
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
E
A
P
------------------------------
F
K
F
D
M
E
L
-
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
Q
P
------------
39
HHSearch
81.33
38%
-102
- C1 -
-
4O2Z
1
?
A:
[31-346]
------------------------------------
F
K
V
Y
N
V
S
G
S
P
F
E
V
P
S
K
-
Y
T
L
L
K
I
L
G
M
G
A
Y
G
I
A
C
S
C
L
D
G
D
------------------------------------------------------------------
T
G
---
E
K
V
S
I
K
K
C
R
D
V
F
R
D
V
E
D
G
K
R
V
L
R
E
I
D
M
M
R
F
F
H
-
H
E
N
L
L
N
V
V
N
I
L
P
P
L
K
R
----
E
Y
H
S
F
E
D
V
Y
V
V
T
P
L
M
D
V
D
M
N
V
V
L
R
S
R
Q
V
L
E
E
S
H
M
Q
Y
F
V
Y
Q
I
L
R
G
L
K
Y
L
H
S
A
N
V
A
H
R
D
L
K
P
A
N
L
V
T
N
I
S
C
E
L
K
I
I
D
F
G
L
S
R
S
--
V
P
Y
------------------------------------------------
S
E
L
T
D
Y
V
I
T
R
W
Y
R
P
P
E
L
L
L
-
E
N
T
N
-
Y
S
T
A
V
D
I
W
S
V
G
C
I
F
A
E
M
Y
N
R
K
P
V
F
P
G
R
N
T
M
D
Q
L
R
-----------------
M
I
A
Q
H
I
G
K
P
P
A
S
I
----
V
E
-----------
H
R
E
A
L
E
K
L
N
E
L
--------------
P
---
D
G
S
L
N
I
P
--
K
L
V
P
G
L
A
G
N
T
E
G
I
D
-
F
L
S
K
M
W
T
L
D
P
S
K
R
P
T
A
A
D
M
L
A
H
P
Y
L
A
H
L
H
D
E
E
D
E
P
T
C
--------------------------------------------------------------------------
42
HHSearch
79.67
34%
-136
- C1 -
-
4H36
-
MK10_HUMAN
A:
[4-322]
------------------------------------
F
Y
S
V
E
V
G
D
S
T
F
T
V
L
K
R
-
Y
Q
N
L
K
P
I
G
S
G
A
Q
G
I
V
C
A
A
Y
D
A
V
------------------------------------------------------------------
L
D
---
R
N
V
A
I
K
K
L
S
R
P
F
Q
N
Q
T
H
A
K
R
A
Y
R
E
L
V
L
M
K
C
V
N
-
H
K
N
I
I
S
L
L
N
V
F
T
P
Q
K
T
-----
L
E
E
F
Q
D
V
Y
L
V
M
E
L
M
D
A
N
L
C
Q
V
I
Q
M
--
E
L
D
H
E
R
M
S
Y
L
L
Y
Q
M
L
C
G
I
K
H
L
H
S
A
G
I
I
H
R
D
L
K
P
S
N
I
V
V
K
S
D
C
T
L
K
I
L
D
F
G
L
A
R
T
A
G
T
S
-------------------------------------------------
F
M
M
T
P
Y
V
V
T
R
Y
Y
R
A
P
E
V
I
L
-
G
-
M
G
-
Y
K
E
N
V
D
I
W
S
V
G
C
I
M
G
E
M
V
R
H
K
I
L
F
P
G
R
D
Y
I
D
Q
W
N
-----------------
K
V
I
E
Q
L
G
T
---
P
C
-
P
E
F
M
K
K
--
L
-
Q
P
T
V
R
N
Y
V
E
N
R
P
K
Y
A
G
------------
L
T
F
P
K
L
F
P
D
-
S
-
L
F
P
---
E
H
N
K
L
K
A
S
Q
A
R
D
-
L
L
S
K
M
L
V
I
D
P
A
K
R
I
S
V
D
D
A
L
Q
H
P
Y
I
N
V
W
Y
D
P
A
-------------------------------------------------------------------------------
24
HHSearch
76.66
40%
-26
- C1 -
-
5CI6
-
MPK6_ARATH
B:
[20-369]
-----------------------------------
R
F
I
Q
Y
N
I
F
G
N
I
F
E
V
T
A
K
Y
K
P
P
I
M
P
I
G
K
G
A
Y
G
I
V
C
S
A
M
N
S
E
------------------------------------------------------------------
T
N
---
E
S
V
A
I
K
K
I
A
N
A
F
D
N
K
I
D
A
K
R
T
L
R
E
I
K
L
L
R
H
M
D
-
H
E
N
I
V
A
I
R
D
I
I
P
P
P
L
R
------
N
A
F
N
D
V
Y
I
A
Y
E
L
M
D
T
D
L
H
Q
I
I
R
S
N
Q
A
L
S
E
E
H
C
Q
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
A
N
C
D
L
K
I
C
D
F
G
L
A
R
V
T
-----------------------------------------------------------
V
T
R
W
Y
R
A
P
E
L
L
L
-
N
S
S
D
-
Y
T
A
A
I
D
V
W
S
V
G
C
I
F
M
E
L
M
D
R
K
P
L
F
P
G
R
D
H
V
H
Q
L
R
-----------------
L
L
M
E
L
I
G
T
---
P
S
----
L
E
F
---
L
N
E
N
A
K
R
Y
I
R
Q
L
P
P
Y
P
R
-------------------
Q
--
S
-
I
T
-
D
K
F
P
---
T
V
H
P
L
A
I
D
-
L
I
E
K
M
L
T
F
D
P
R
R
R
I
T
V
L
D
A
L
A
H
P
Y
L
N
S
L
H
D
I
S
D
E
P
E
C
T
I
P
------------------------------
F
N
F
D
F
E
N
-
H
A
L
S
E
E
Q
M
K
E
L
I
Y
R
E
A
L
A
F
N
P
E
Y
Q
---------
25
HHSearch
76.00
32%
-91
- C1 -
-
3N9X
4
?
B:
[22-411]
----------------------------------------------
V
H
V
P
D
N
-
Y
I
I
K
H
L
I
G
R
G
S
Y
G
Y
V
Y
L
A
Y
D
K
N
------------------------------------------------------------------
T
E
---
K
N
V
A
I
K
K
V
N
R
M
F
E
D
L
I
D
C
K
R
I
L
R
E
I
T
I
L
N
R
L
K
-
S
D
Y
I
I
R
L
Y
D
L
I
I
P
D
D
------
L
L
K
F
D
E
L
Y
I
V
L
E
I
A
D
S
D
L
K
K
L
F
K
T
P
I
F
L
T
E
E
H
I
K
T
I
L
Y
N
L
L
L
G
E
N
F
I
H
E
S
G
I
I
H
R
D
L
K
P
A
N
C
L
L
N
Q
D
C
S
V
K
V
C
D
F
G
L
A
R
T
I
N
-------------------------------------------------------
S
H
V
V
T
R
W
Y
R
A
P
E
L
I
L
-
L
Q
E
N
-
Y
T
K
S
I
D
I
W
S
T
G
C
I
F
A
E
L
L
N
M
L
Q
S
H
I
N
D
P
T
N
R
F
P
L
FPGSSCFH
E
K
S
N
R
D
Q
L
N
I
I
F
N
I
I
G
T
---
P
T
-
E
D
D
L
K
N
--
I
-
K
P
E
V
I
K
Y
I
K
L
F
P
H
R
K
--------------------
P
----
I
--
N
L
K
Q
K
Y
P
S
I
S
D
D
G
I
N
-
L
L
E
S
M
L
K
F
N
P
N
K
R
I
T
I
D
Q
A
L
D
H
P
Y
L
K
D
V
R
K
K
K
L
E
---
T
K
K
------------------------------
I
I
L
P
F
D
D
W
M
V
L
S
E
T
Q
L
R
Y
I
F
L
K
E
V
Q
S
F
H
P
E
L
----------
27
HHSearch
75.13
37%
-92
- C- -
-
3COI
-
MK13_HUMAN
A:
[12-351]
---------------------------------------
Q
D
V
N
K
T
A
W
E
L
P
K
T
-
Y
V
S
P
T
H
V
G
S
G
A
Y
G
S
V
C
S
A
I
D
K
R
------------------------------------------------------------------
S
G
---
E
K
V
A
I
K
K
L
S
R
P
F
Q
S
E
I
F
A
K
R
A
Y
R
E
L
L
L
L
K
H
M
Q
-
H
E
N
V
I
G
L
L
D
V
F
T
P
A
S
S
-----
L
R
N
F
Y
D
F
Y
L
V
M
P
F
M
Q
T
D
L
Q
K
I
M
G
--
L
K
F
S
E
E
K
I
Q
Y
L
V
Y
Q
M
L
K
G
L
K
Y
I
H
S
A
G
V
V
H
R
D
L
K
P
G
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
R
H
-----------------------------------------------------------
V
V
T
R
W
Y
R
A
P
E
V
I
L
-
S
W
M
H
-
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
M
L
T
G
K
T
L
F
K
G
K
D
Y
L
D
Q
L
T
-----------------
Q
I
L
K
V
T
G
V
---
P
G
-
T
E
F
V
Q
K
--
L
N
D
K
A
A
K
S
Y
I
Q
S
L
P
Q
T
P
--------------------
R
--
K
D
F
T
-
Q
L
F
P
---
R
A
S
P
Q
A
A
D
-
L
L
E
K
M
L
E
L
D
V
D
K
R
L
T
A
A
Q
A
L
T
H
P
F
F
E
P
F
R
D
P
E
E
E
T
E
A
Q
Q
P
------------------------------
F
D
D
S
L
E
H
-
E
K
L
T
V
D
E
W
K
Q
H
I
Y
K
E
I
V
N
F
S
P
------------
28
HHSearch
75.07
36%
-88
- C1 -
-
3OZ6
-
?
A:
[7-345]
------------------------------------------------
V
L
R
K
-
Y
E
L
V
K
K
-------
I
V
W
K
S
I
D
R
R
------------------------------------------------------------------
T
G
---
E
V
V
A
V
K
K
I
F
D
--
Q
N
S
T
D
A
Q
R
T
F
R
E
I
M
I
L
T
E
L
S
G
H
E
N
I
V
N
L
L
N
V
L
R
A
D
---------
N
D
R
D
V
Y
L
V
F
D
Y
M
E
T
D
L
H
A
V
I
R
A
-
N
I
L
E
P
V
H
K
Q
Y
V
V
Y
Q
L
I
K
V
I
K
Y
L
H
S
G
G
L
L
H
R
D
M
K
P
S
N
I
L
L
N
A
E
C
H
V
K
V
A
D
F
G
L
S
R
S
F
V
N
I
R
R
V
T
N
N
-
I
P
L
S
I
---------------
N
--------------------------
Y
V
A
T
R
W
Y
R
A
P
E
I
L
L
-
G
S
T
K
-
Y
T
K
G
I
D
M
W
S
L
G
C
I
L
G
E
I
L
C
G
K
P
I
F
P
G
S
S
T
M
N
Q
L
E
-----------------
R
I
I
G
V
I
D
F
---
P
S
-
N
E
D
V
E
S
--
I
Q
S
P
F
A
K
T
M
I
E
S
L
K
E
K
V
E
-----------
K
R
D
I
F
T
--
K
W
K
N
-
L
L
-
L
K
I
N
P
K
A
D
C
N
E
E
A
L
D
-
L
L
D
K
L
L
Q
F
N
P
N
K
R
I
S
A
N
D
A
L
K
H
P
F
V
S
I
F
H
N
P
N
-------------------------------------------------------------------------------
31
HHSearch
74.22
36%
-86
- C1 -
-
4YNO
-
MK13_HUMAN
A:
[2-351]
-----------------------------
S
L
I
R
K
K
G
F
Y
K
Q
D
V
N
K
T
A
W
E
L
P
K
T
-
Y
V
S
P
T
H
V
G
S
G
A
Y
G
S
V
C
S
A
I
D
K
R
------------------------------------------------------------------
S
G
---
E
K
V
A
I
K
K
L
S
R
P
F
Q
S
E
I
F
A
K
R
A
Y
R
E
L
L
L
L
K
H
M
Q
-
H
E
N
V
I
G
L
L
D
V
F
T
P
A
S
S
-----
L
R
N
F
Y
D
F
Y
L
V
M
P
F
M
Q
T
D
L
Q
K
I
M
G
--
M
E
F
S
E
E
K
I
Q
Y
L
V
Y
Q
M
L
K
G
L
K
Y
I
H
S
A
G
V
V
H
R
D
L
K
P
G
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
-----------------------------------------------------------
G
Y
V
V
T
R
W
Y
R
A
P
E
V
I
L
-
S
W
M
H
-
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
M
L
T
G
K
T
L
F
K
G
K
D
Y
L
D
Q
L
T
-----------------
Q
I
L
K
V
T
G
V
---
P
G
-
T
E
F
V
Q
K
--
L
N
D
K
A
A
K
S
Y
I
Q
S
L
P
Q
T
P
--------------------
R
--
K
D
F
T
-
Q
L
F
---
P
R
A
S
P
Q
A
A
D
-
L
L
E
K
M
L
E
L
D
V
D
K
R
L
T
A
A
Q
A
L
T
H
P
F
F
E
P
F
R
D
P
E
E
E
T
E
A
Q
Q
P
------------------------------
F
D
D
S
L
E
H
-
E
K
L
T
V
D
E
W
K
Q
H
I
Y
K
E
I
V
N
F
S
P
------------
34
HHSearch
74.20
37%
-117
- C1 -
-
2YIX
1
MK14_HUMAN
A:
[11-315]
------------------------------------------
N
K
T
I
W
E
V
P
E
R
-
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
D
T
K
------------------------------------------------------------------
T
G
---
L
R
V
A
V
K
K
L
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
-
H
E
N
V
I
G
L
L
D
V
F
T
P
A
R
S
-----
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
K
C
-
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
R
H
T
D
D
E
---------------------------------------------------
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
-
N
W
M
H
-
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
-----------------
L
I
L
R
L
V
G
T
P
G
A
E
----
L
L
K
K
--
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
Q
M
P
K
------------------------
M
--
N
F
A
N
V
F
I
G
A
N
P
L
A
V
D
-
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
----------------------------------------------------------------------------
29
HHSearch
73.87
38%
-126
- C1 -
-
2FST
3
MK14_HUMAN
X:
[22-324]
-------------------------------------------
K
T
I
W
E
V
P
E
R
-
Y
Q
N
L
S
P
V
G
----
G
S
V
C
A
A
F
D
T
K
------------------------------------------------------------------
T
G
---
L
R
V
A
V
K
K
L
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
-
H
E
N
V
I
G
L
L
D
V
F
T
P
A
R
S
-----
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
------
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
------------------------------------------------------------------
A
T
R
W
Y
R
A
P
E
I
M
L
-
N
W
M
H
-
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
-----------------
L
I
L
R
L
V
G
T
P
---
G
-
A
E
L
L
K
K
--
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
Q
M
P
K
M
------------------
N
----
F
A
-
N
V
F
---
I
G
A
N
P
L
A
V
D
-
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
-----------------------------------------------------------------------------
12
PsiBlast_PDB
72.08
33%
-95
- C1 -
-
2ZOQ
1
MK03_HUMAN
A:
[71-358]
----------------------------------------------------------------------------------------------------------------------------------------------------
V
A
I
K
K
I
S
P
-
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
Q
I
L
L
R
F
R
-
H
E
N
V
I
G
I
R
D
I
L
R
------
A
S
T
L
E
A
M
R
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
K
S
-
Q
Q
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
I
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
I
A
D
P
E
H
D
H
T
G
F
L
---------------------------------------------
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
-
N
-
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
Q
L
N
-----------------
H
I
L
---
G
I
L
G
S
P
S
Q
E
D
---------------
L
N
C
I
I
N
M
K
A
R
------
N
Y
L
Q
S
L
P
S
K
T
K
V
A
W
A
K
L
F
P
K
S
-
D
S
K
A
L
D
--------
L
L
D
R
M
L
T
F
N
P
N
K
R
I
T
V
E
E
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
T
D
E
P
V
---
A
E
E
P
F
T
F
A
M
E
L
D
D
L
----------------------------------------------------------
10
PsiBlast_PDB
71.95
33%
-94
- C1 -
-
4QTB
14
MK03_HUMAN
A:
[69-356]
----------------------------------------------------------------------------------------------------------------------------------------------------
V
A
I
K
K
I
S
P
-
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
Q
I
L
L
R
F
R
-
H
E
N
V
I
G
I
R
D
I
L
R
------
A
S
T
L
E
A
M
R
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
K
S
-
Q
Q
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
I
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
I
A
D
P
E
H
D
H
T
G
F
L
---------------------------------------------
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
-
N
-
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
Q
L
N
-----------------
H
I
L
---
G
I
L
G
S
P
S
Q
E
D
---------------
L
N
C
I
I
N
M
K
A
R
------
N
Y
L
Q
S
L
P
S
K
T
K
V
A
W
A
K
L
F
P
K
S
-
D
S
K
A
L
D
--------
L
L
D
R
M
L
T
F
N
P
N
K
R
I
T
V
E
E
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
T
D
E
P
V
---
A
E
E
P
F
T
F
A
M
E
L
D
D
L
----------------------------------------------------------
1
PsiBlast_PDB
68.95
33%
-82
- C1 -
-
4IC7
1
MK07_HUMAN
A:
[83-374]
----------------------------------------------------------------------------------------------------------------------------------------------------
V
A
I
K
K
I
P
N
A
F
D
V
V
T
N
A
K
R
T
L
R
E
L
K
I
L
K
H
F
K
-
H
D
N
I
I
A
I
K
D
I
L
R
P
T
V
P
Y
G
E
-----
F
K
S
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
H
S
S
Q
P
L
T
L
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
E
N
C
E
L
K
I
G
D
F
G
M
A
R
G
------------------------------
L
C
--------
T
S
P
A
E
H
Q
------
Y
F
M
T
E
Y
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
-
H
E
-
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
R
R
Q
L
F
P
G
K
N
Y
V
H
Q
L
Q
-----------------
L
I
M
M
V
L
G
------
T
P
S
P
A
V
I
Q
A
V
G
A
E
R
V
R
A
Y
I
Q
S
L
P
P
R
Q
P
V
P
W
E
T
V
Y
P
G
A
D
R
Q
A
L
S
---------------------------
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
Y
H
D
P
D
D
E
P
D
C
A
P
P
F
D
F
A
F
D
R
E
A
L
-------------------------------------------------------------
7
PsiBlast_PDB
67.88
33%
-75
- C1 -
-
5BYZ
7
MK07_HUMAN
A:
[34-325]
----------------------------------------------------------------------------------------------------------------------------------------------------
V
A
I
K
K
I
P
N
A
F
D
V
V
T
N
A
K
R
T
L
R
E
L
K
I
L
K
H
F
K
-
H
D
N
I
I
A
I
K
D
I
L
R
P
T
V
P
Y
G
E
-----
F
K
S
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
H
S
S
Q
P
L
T
L
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
E
N
C
E
L
K
I
G
D
F
G
M
A
R
G
------------------------------
L
C
--------
T
S
P
A
E
H
Q
------
Y
F
M
T
E
Y
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
-
H
E
-
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
R
R
Q
L
F
P
G
K
N
Y
V
H
Q
L
Q
-----------------
L
I
M
M
V
L
G
------
T
P
S
P
A
V
I
Q
A
V
G
A
E
R
V
R
A
Y
I
Q
S
L
P
P
R
Q
P
V
P
W
E
T
V
Y
P
G
A
D
R
Q
A
L
S
---------------------------
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
Y
H
D
P
D
D
E
P
D
C
A
P
P
F
D
F
A
F
D
R
E
A
L
-------------------------------------------------------------
3
PsiBlast_PDB
67.85
33%
-80
- C1 -
-
4ZSG
6
MK07_HUMAN
A:
[35-326]
----------------------------------------------------------------------------------------------------------------------------------------------------
V
A
I
K
K
I
P
N
A
F
D
V
V
T
N
A
K
R
T
L
R
E
L
K
I
L
K
H
F
K
-
H
D
N
I
I
A
I
K
D
I
L
R
P
T
V
P
Y
G
E
-----
F
K
S
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
H
S
S
Q
P
L
T
L
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
E
N
C
E
L
K
I
G
D
F
G
M
A
R
G
------------------------------
L
C
--------
T
S
P
A
E
H
Q
------
Y
F
M
T
E
Y
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
-
H
E
-
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
R
R
Q
L
F
P
G
K
N
Y
V
H
Q
L
Q
-----------------
L
I
M
M
V
L
G
------
T
P
S
P
A
V
I
Q
A
V
G
A
E
R
V
R
A
Y
I
Q
S
L
P
P
R
Q
P
V
P
W
E
T
V
Y
P
G
A
D
R
Q
A
L
S
---------------------------
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
Y
H
D
P
D
D
E
P
D
C
A
P
P
F
D
F
A
F
D
R
E
A
L
-------------------------------------------------------------
5
PsiBlast_PDB
67.51
33%
-77
- C1 -
-
4ZSL
6
MK07_HUMAN
A:
[29-320]
----------------------------------------------------------------------------------------------------------------------------------------------------
V
A
I
K
K
I
P
N
A
F
D
V
V
T
N
A
K
R
T
L
R
E
L
K
I
L
K
H
F
K
-
H
D
N
I
I
A
I
K
D
I
L
R
P
T
V
P
Y
G
E
-----
F
K
S
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
H
S
S
Q
P
L
T
L
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
E
N
C
E
L
K
I
G
D
F
G
M
A
R
G
------------------------------
L
C
--------
T
S
P
A
E
H
Q
------
Y
F
M
T
E
Y
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
-
H
E
-
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
R
R
Q
L
F
P
G
K
N
Y
V
H
Q
L
Q
-----------------
L
I
M
M
V
L
G
------
T
P
S
P
A
V
I
Q
A
V
G
A
E
R
V
R
A
Y
I
Q
S
L
P
P
R
Q
P
V
P
W
E
T
V
Y
P
G
A
D
R
Q
A
L
S
---------------------------
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
Y
H
D
P
D
D
E
P
D
C
A
P
P
F
D
F
A
F
D
R
E
A
L
-------------------------------------------------------------
14
PsiBlast_PDB
67.06
33%
-99
- C1 -
-
2B9I
1
FUS3_YEAST
A:
[39-318]
----------------------------------------------------------------------------------------------------------------------------------------------------
V
A
I
K
K
I
-
E
P
F
D
K
P
L
F
A
L
R
T
L
R
E
I
K
I
L
K
H
F
K
-
H
E
N
I
I
T
I
F
N
I
Q
R
P
------
D
S
F
E
N
F
N
E
V
Y
I
I
Q
E
L
M
Q
T
D
L
H
R
V
I
-
S
T
Q
M
L
S
D
D
H
I
Q
Y
F
I
Y
Q
T
L
R
A
V
K
V
L
H
G
S
N
V
I
H
R
D
L
K
P
S
N
L
L
I
N
S
N
C
D
L
K
V
C
D
F
G
L
A
R
----------------
I
I
D
E
-------------------------------------
V
E
F
V
A
T
R
W
Y
R
A
P
E
V
M
L
-
T
S
A
K
-
Y
S
R
A
M
D
V
W
S
C
G
C
I
L
A
E
L
F
L
R
R
P
I
F
P
G
R
D
Y
R
H
Q
L
L
-----------------
L
I
F
---
G
I
I
G
T
P
-----------------
H
S
D
N
D
L
R
C
I
E
S
P
------
R
A
R
E
Y
I
K
-
S
L
P
M
Y
P
A
A
P
L
E
K
M
F
P
R
V
N
P
K
-----
G
I
D
L
L
Q
R
M
L
V
F
D
P
A
K
R
I
T
A
K
E
A
L
E
H
P
Y
L
Q
T
Y
H
D
P
N
D
E
-----------------------------------------------------------------------------
6
PsiBlast_PDB
66.83
33%
-73
- C1 -
-
5BYY
1
MK07_HUMAN
A:
[33-324]
----------------------------------------------------------------------------------------------------------------------------------------------------
V
A
I
K
K
I
P
N
A
F
D
V
V
T
N
A
K
R
T
L
R
E
L
K
I
L
K
H
F
K
-
H
D
N
I
I
A
I
K
D
I
L
R
P
T
V
P
Y
G
E
-----
F
K
S
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
H
S
S
Q
P
L
T
L
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
E
N
C
E
L
K
I
G
D
F
G
M
A
R
G
------------------------------
L
----------------------
Y
F
M
T
E
Y
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
-
H
E
-
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
R
R
Q
L
F
P
G
K
N
Y
V
H
Q
L
Q
-----------------
L
I
M
M
V
L
G
------
T
P
S
P
A
V
I
Q
A
V
G
A
E
R
V
R
A
Y
I
Q
S
L
P
P
R
Q
P
V
P
W
E
T
V
Y
P
G
A
D
R
Q
A
L
S
---------------------------
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
Y
H
D
P
D
D
E
P
D
C
A
P
P
F
D
F
A
F
D
R
E
A
L
-------------------------------------------------------------
2
PsiBlast_PDB
66.29
33%
-94
- C1 -
-
4B99
1
MK07_HUMAN
A:
[82-373]
----------------------------------------------------------------------------------------------------------------------------------------------------
V
A
I
K
K
I
P
N
A
F
D
V
V
T
N
A
K
R
T
L
R
E
L
K
I
L
K
H
F
K
-
H
D
N
I
I
A
I
K
D
I
L
R
P
T
V
P
Y
G
E
-----
F
K
S
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
H
S
S
Q
P
L
T
L
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
E
N
C
E
L
K
I
G
D
F
G
M
A
R
G
------------------------------
L
---------------
Q
------
Y
F
M
T
E
Y
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
-
H
E
-
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
R
R
Q
L
F
P
G
K
N
Y
V
H
Q
L
Q
-----------------
L
I
M
M
V
L
G
------
T
P
S
P
A
V
I
Q
-----
R
V
R
A
Y
I
Q
S
L
P
P
R
Q
P
V
P
W
E
T
V
Y
P
G
A
D
R
Q
A
L
S
---------------------------
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
Y
H
D
P
D
D
E
P
D
C
A
P
P
F
D
F
A
F
D
R
E
A
L
-------------------------------------------------------------
15
PsiBlast_PDB
65.61
33%
-98
- C1 -
-
2B9J
1
FUS3_YEAST
A:
[39-318]
----------------------------------------------------------------------------------------------------------------------------------------------------
V
A
I
K
K
I
-
E
P
F
D
K
P
L
F
A
L
R
T
L
R
E
I
K
I
L
K
H
F
K
-
H
E
N
I
I
T
I
F
N
I
Q
R
P
------
D
S
F
E
N
F
N
E
V
Y
I
I
Q
E
L
M
Q
T
D
L
H
R
V
I
-
S
T
Q
M
L
S
D
D
H
I
Q
Y
F
I
Y
Q
T
L
R
A
V
K
V
L
H
G
S
N
V
I
H
R
D
L
K
P
S
N
L
L
I
N
S
N
C
D
L
K
V
C
D
F
G
L
A
R
----------------
I
I
D
--------------------------------------
V
E
F
V
A
T
R
W
Y
R
A
P
E
V
M
L
-
T
S
A
K
-
Y
S
R
A
M
D
V
W
S
C
G
C
I
L
A
E
L
F
L
R
R
P
I
F
P
G
R
D
Y
R
H
Q
L
L
-----------------
L
I
F
---
G
I
I
G
T
P
-----------------
H
S
D
N
D
L
R
C
I
E
S
P
------
R
A
R
E
Y
I
K
-
S
L
P
M
Y
P
A
A
P
L
E
K
M
F
P
R
V
N
P
K
-----
G
I
D
L
L
Q
R
M
L
V
F
D
P
A
K
R
I
T
A
K
E
A
L
E
H
P
Y
L
Q
T
Y
H
D
P
N
D
E
-----------------------------------------------------------------------------
9
PsiBlast_PDB
65.52
34%
-93
- C1 -
-
2B9F
1
FUS3_YEAST
A:
[39-318]
----------------------------------------------------------------------------------------------------------------------------------------------------
V
A
I
K
K
I
-
E
P
F
D
K
P
L
F
A
L
R
T
L
R
E
I
K
I
L
K
H
F
K
-
H
E
N
I
I
T
I
F
N
I
Q
R
P
------
D
S
F
E
N
F
N
E
V
Y
I
I
Q
E
L
M
Q
T
D
L
H
R
V
I
-
S
T
Q
M
L
S
D
D
H
I
Q
Y
F
I
Y
Q
T
L
R
A
V
K
V
L
H
G
S
N
V
I
H
R
D
L
K
P
S
N
L
L
I
N
S
N
C
D
L
K
V
C
D
F
G
L
A
R
----------------
I
I
D
--------------------------------------
T
E
Y
V
A
T
R
W
Y
R
A
P
E
V
M
L
-
T
S
A
K
-
Y
S
R
A
M
D
V
W
S
C
G
C
I
L
A
E
L
F
L
R
R
P
I
F
P
G
R
D
Y
R
H
Q
L
L
-----------------
L
I
F
---
G
I
I
G
T
P
-----------------
H
S
D
N
D
L
R
C
I
E
S
P
------
R
A
R
E
Y
I
K
-
S
L
P
M
Y
P
A
A
P
L
E
K
M
F
P
R
V
N
P
K
-----
G
I
D
L
L
Q
R
M
L
V
F
D
P
A
K
R
I
T
A
K
E
A
L
E
H
P
Y
L
Q
T
Y
H
D
P
N
D
E
-----------------------------------------------------------------------------
13
PsiBlast_PDB
65.13
33%
-96
- C1 -
-
2B9H
1
FUS3_YEAST
A:
[39-318]
----------------------------------------------------------------------------------------------------------------------------------------------------
V
A
I
K
K
I
-
E
P
F
D
K
P
L
F
A
L
R
T
L
R
E
I
K
I
L
K
H
F
K
-
H
E
N
I
I
T
I
F
N
I
Q
R
P
------
D
S
F
E
N
F
N
E
V
Y
I
I
Q
E
L
M
Q
T
D
L
H
R
V
I
-
S
T
Q
M
L
S
D
D
H
I
Q
Y
F
I
Y
Q
T
L
R
A
V
K
V
L
H
G
S
N
V
I
H
R
D
L
K
P
S
N
L
L
I
N
S
N
C
D
L
K
V
C
D
F
G
L
A
R
----------------
I
I
D
--------------------------------------
V
E
F
V
A
T
R
W
Y
R
A
P
E
V
M
L
-
T
S
A
K
-
Y
S
R
A
M
D
V
W
S
C
G
C
I
L
A
E
L
F
L
R
R
P
I
F
P
G
R
D
Y
R
H
Q
L
L
-----------------
L
I
F
---
G
I
I
G
T
P
-----------------
H
S
D
N
D
L
R
C
I
E
S
P
------
R
A
R
E
Y
I
K
-
S
L
P
M
Y
P
A
A
P
L
E
K
M
F
P
R
V
N
P
K
-----
G
I
D
L
L
Q
R
M
L
V
F
D
P
A
K
R
I
T
A
K
E
A
L
E
H
P
Y
L
Q
T
Y
H
D
P
N
D
E
-----------------------------------------------------------------------------
18
PsiBlast_PDB
64.05
32%
-92
- C1 -
-
4EYM
1
MK13_HUMAN
A:
[70-352]
----------------------------------------------------------------------------------------------------------------------------------------------------
V
A
I
K
K
L
S
R
P
F
Q
S
E
I
F
A
K
R
A
Y
R
E
L
L
L
L
K
H
M
Q
-
H
E
N
V
I
G
L
L
D
V
F
T
P
-----
A
S
S
L
R
N
F
Y
D
F
Y
L
V
M
P
F
M
Q
T
D
L
Q
K
I
M
--
G
M
E
F
S
E
E
K
I
Q
Y
L
V
Y
Q
M
L
K
G
L
K
Y
I
H
S
A
G
V
V
H
R
D
L
K
P
G
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
-------------------------------------------------------------
Y
V
V
T
R
W
Y
R
A
P
E
V
I
L
S
W
-
M
H
-
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
M
L
T
G
K
T
L
F
K
G
K
D
Y
L
D
Q
L
T
-----------------
Q
I
L
K
V
T
G
V
P
G
T
----
E
F
V
Q
K
L
--
N
D
K
A
A
K
S
Y
I
Q
S
L
--
P
Q
T
P
------
R
-
K
D
F
T
Q
L
F
P
R
A
S
P
Q
A
-----------------
A
D
-
L
L
E
K
M
L
E
L
D
V
D
K
R
L
T
A
A
Q
A
L
T
H
P
F
F
E
P
F
R
D
P
E
E
E
T
E
A
Q
Q
P
F
D
D
S
L
E
H
E
K
L
-------------------------------------------------------------
11
PsiBlast_PDB
63.79
33%
-94
- C1 -
-
2F9G
1
FUS3_YEAST
A:
[39-318]
----------------------------------------------------------------------------------------------------------------------------------------------------
V
A
I
K
K
I
-
E
P
F
D
K
P
L
F
A
L
R
T
L
R
E
I
K
I
L
K
H
F
K
-
H
E
N
I
I
T
I
F
N
I
Q
R
P
------
D
S
F
E
N
F
N
E
V
Y
I
I
Q
E
L
M
Q
T
D
L
H
R
V
I
-
S
T
Q
M
L
S
D
D
H
I
Q
Y
F
I
Y
Q
T
L
R
A
V
K
V
L
H
G
S
N
V
I
H
R
D
L
K
P
S
N
L
L
I
N
S
N
C
D
L
K
V
C
D
F
G
L
A
R
----------------
I
I
D
-------------------------------------------
T
R
W
Y
R
A
P
E
V
M
L
-
T
S
A
K
-
Y
S
R
A
M
D
V
W
S
C
G
C
I
L
A
E
L
F
L
R
R
P
I
F
P
G
R
D
Y
R
H
Q
L
L
-----------------
L
I
F
---
G
I
I
G
T
P
-----------------
H
S
D
N
D
L
R
C
I
E
S
P
------
R
A
R
E
Y
I
K
-
S
L
P
M
Y
P
A
A
P
L
E
K
M
F
P
R
V
N
P
K
-----
G
I
D
L
L
Q
R
M
L
V
F
D
P
A
K
R
I
T
A
K
E
A
L
E
H
P
Y
L
Q
T
Y
H
D
P
N
D
E
-----------------------------------------------------------------------------
20
PsiBlast_PDB
59.63
32%
-82
- C1 -
-
5EKN
1
MK13_HUMAN
A:
[70-352]
----------------------------------------------------------------------------------------------------------------------------------------------------
V
A
I
K
K
L
S
R
P
F
Q
S
E
I
F
A
K
R
A
Y
R
E
L
L
L
L
K
H
M
Q
-
H
E
N
V
I
G
L
L
D
V
F
T
P
-----
A
S
S
L
R
N
F
Y
D
F
Y
L
V
M
P
F
M
Q
T
D
L
Q
K
I
M
--
G
M
E
F
S
E
E
K
I
Q
Y
L
V
Y
Q
M
L
K
G
L
K
Y
I
H
S
A
G
V
V
H
R
D
L
K
P
G
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
-----------------------------------------------------------------
V
T
R
W
Y
R
A
P
E
V
I
L
S
W
-
M
H
-
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
M
L
T
G
K
T
L
F
K
G
K
D
Y
L
D
Q
L
T
-----------------
Q
I
L
K
V
T
G
V
P
G
T
----
E
F
V
Q
K
L
--
N
D
K
A
A
K
S
Y
I
Q
S
L
--
P
Q
T
P
------
R
-
K
D
F
T
Q
L
F
P
R
A
S
P
Q
A
-----------------
A
D
-
L
L
E
K
M
L
E
L
D
V
D
K
R
L
T
A
A
Q
A
L
T
H
P
F
F
E
P
F
R
D
P
E
E
E
T
E
A
Q
Q
P
F
D
D
S
L
E
H
E
K
L
-------------------------------------------------------------