@TOME V2.3
(Mar 2018)

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Alignment:

3D Common Core:

Structural Clustering:

Modeller Result :

Complexes Modeling
Templates Information:
Sequence & Result Tab:

Values color: [ Good | Correct | Middling | Bad ]Sequence color : MutatedHelixStrandConserved

Query sequence : LINJ_14_0020: (2018-07-12 )
MSLRVRLRVPKQWDRFQVNIDEELQQEELSRTLTEREIDDFNRRNLHSVSELSDHLRLLVFGSDECVTCSEDICAAVEYIVGPQRRWNSSCDEVCEFRRAISRAYLNEWKAFQSVHPSVPERLATRSLPQVFSVPPLQKAQMDLLMQMCPRNAETGDGSISMRLWYLDSAGSRCSTRRRFPFDTAADDAIRLTMSSAREFASMREKTDDTPLIFVFRVKGRNEYIYGSQPLINYRYIRHCVSKRAEIDLVVEPKEATLFAVPLFRPSYPSRTLASPSDADASKSSTSEICLWDLTSKLSIRIVGGFEKLAISASRMKDENVRDSSSLYFAVLVEAYVGTWRCCEPQITDWQLCENAKNSHSLAARVYWKDGGTVTFSIDLSNVPRELKLCFTLVASSTDRIVGARAATAEEVIAAVEVNTKKTDDQGHSVFFLGTAATQLFDYAAKMRMGMWRIYLWEGKTRANPIGLNSINPDSNACTFEVEFPCFDKPVFFPSGRPPKRKEEDARRNFADREAALSSYLINNEVEQLRQLKRVLMYDPLVHLSSDDKTILWKYREMLLGQPKAMAKVMSAVNWLMPFDVYEAHCLLRRWSPLAAFDALELLDAHYADLAVREQAVEYIDKMSDYELRGCILQLVQVLKYEPYHYSALARFLLRRSLRSNHIIGHYVFWYLAAEVKNLTICERHGLLLEELIKRSPHRLDYVRQVYVCNELLKCALRVQRAPKKDRVKCLRASLAKVRFPHRFTLALNPSVECCAVDIDECKVMESKKFPLWLAFRNHLDQDEHFFIIFKSGDDLRQDLLTLQLLEFMDSLWKASGLDLHLIPYGCISTGEGVGMIEVVLNSDTIANITRREGGAQAAFNVDPIINWLRQFNHDRGEVERCLWNFVLSVAGYTVATYVLGIGDRHNDNIMLRQDGTLFHIDFGHFLGNFKTKFGIKRETAPFIFTPMYLYAMGGSSSPIFKYFVDVACRAYNALRRHSSALMMLFMLMLSTGIPELQTLEDIEWLRTVLLLNRTDEEASDHYKGLINDALGNFRTLLNDYIHIMVH

Atome Classification :

(22 SA) .........10........20........30........40...-.....50........60........70........80..--......90........100.......110.......120.......130.......140.......150.......160.......170........180.....-..190.......200.......-210.......220.......230.......240...-------....250.......260---..---......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.....-----..----460---.........470.-.-.-....480......-.-490.......500....------...510..---.....520-..---....--.530......-.540.......550.......560.-.......570.......580.......590...-----....600.......610.......620-.......630.......640....----------...650.......660.......670.....-..--------680.......690...--.-------.-.------.700..-......710...-....720..------.--.---..-.730..-----...---.-------.---740-----.......-------.750.......760.......770......---.780.....----..790.......800.......810.......820.......830.......840.......850..--.....--860.......870.......----880.......890.......900.......910.......920.......930.......940.......950.---...---.---..960---.........970.......980.......990.......1000........1010......1020......1030.......1040....
(Atome) (Ident) (Tito) (Num) (QMean) (Ligand) (Uniprot) MSLRVRLRVPKQWDRFQVNIDEELQQEELSRTLTEREIDDFNRR-NLHSVSELSDHLRLLVFGSDECVTCSEDICAAVEYIVGP--QRRWNSSCDEVCEFRRAISRAYLNEWKAFQSVHPSVPERLATRSLPQVFSVPPLQKAQMDLLMQMCPRNAETGDGSISMRLWYLDSA-GSRCSTRRRFPFDTAAD-DAIRLTMSSAREFASMREKTDD-TPLIFVFRVKGRNEYIYGSQPLINYRYIRHCVSKRA-------EIDLVVEPKEATLFAV----PL---FRPSYPSRTLASPSDADASKSSTSEICLWDLTSKLSIRIVGGFEKLAISASRMKDENVRDSSSLYFAVLVEAYVGTWRCCEPQITDWQLCENAKNSHSLAARVYWKDGGTVTFSIDLSNVPRELKLCFTLVASSTDRIVGARAATAEEVIAAVEVNTKKTDDQGHSVFFLGTAATQLFDYAAKMRMGMWRIYLW-----EG----K-----TRANPIGLNSINP-D-S-NACTFEVEFPCFD-K-PVFFPSGRPPKRKEEDA------RRNFADRE---AALSSYLI-NN---EVEQ--LRQLKRVLMY-DPLVHLSSDDKTILWKYREMLL-GQ-PKAMAKVMSAVNWLMPFDVYEAHCLLRRWSPLA-----AFDALELLDAHYADLAVREQAVEYIDK-MSDYELRGCILQLVQVLKYEPYHY----------SALARFLLRRSLRSNHIIGHYVFWYLAAEVK-NL--------TICERHGLLLEELIKR--S-------P-H------RL-DYV-RQVYVCNELLKC-ALRVQRAPK------K--D---RV-KCLRAS-----LAK---V-------R---FP------HRFTLAL-------NPSVECCAVDIDECKVMESKKFPLWLAFRN---HLDQDEHFF----IIFKSGDDLRQDLLTLQLLEFMDSLWKASGLDLHLIPYGCISTGEGVGMIEVVLNSDTIANITRREG--GAQAA--FNVDPIINWLRQFNHDRGEV----ERCLWNFVLSVAGYTVATYVLGIGDRHNDNIMLRQDGTLFHIDFGHFLGNFKTKFGIKRETAPFIFTPMYLYAM---GGS---S---SPI-----FKYFVDVACRAYNALRRHSSALMMLFMLMLSTGIPELQTL--EDIEWLRTVLLLNRTDEEASDHYKGLINDALG-NFRTLLNDYIHIMVH
3 PsiBlast_PDB 80.5933% - - C3 - - 4OVU - PK3CA_HUMAN A:[250-1052] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YILKVCGCDEYFLEKYPLSQYKYIRSCIMLGR-------MPNLMLMAKESLYSQL----PMDCFTMPSYS----------NGETSTKS---LWVINSALRIKIL---------CATYVNVNIRDIDKIY------VRTGIYHGGEP------LCDNVNTQRVPCSNPRWNEW--LNYDIYIPDLPRAARLCLSICS------VK------EEHCP------------------LAWGNINLFDYTDTLVSGKMALNLW-----PVPHGLE-----DLLNPIGVTGSNP-N-K-ETPCLELEFDWFS-S-VVKFPDM---SVIEEHANWSVSREAGFSYSH---AGLS----RDN---ELRENDKEQLKAISTR-DPLSEITEQEKDFLWSHRHYCV-TI-PEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIK-----PEQAMELLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLD----------NLLVRFLLKKAL-TNQRIGHFFFWHLKSEMH-NK--------TVSQRFGLLLESYCRA--C-------G-M------YL-KHLNRQVEAMEKLINL-T-DILKQEK------K--D---ET-QKVQMKFL---VEQ---M-------R---RPDFMDALQGFLSPL-------NPAHQLGNLRLEECRIMSSAKRPLWLNWEN---PDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLSIGDCVGLIEVVRNSHTIMQIQCK-G--GLKGALQFNSHTLHQWLKDKN--KGEIY---DAAIDLFTRSCAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDFLIVI---SKG---A---QECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSF--DDIAYIRKTLALDKTEQEALEYFMKQMNDAHH-GGWT-----------
50 Fugue 75.2833% -28 - C3 - - 4TUU - PK3CA_HUMAN A:[107-1046] ------------------NREEKILNREIGFAI------GMPVC-EFDMVKD------------------------------------------PEVQDFRRNI-LNVCKEAVDLRDLNSP-HSRAMYVYPPNVESSPELPKHIYNKL----------DKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPE-QVIAEAIRKKTRSMLYQGK--------YILKVCGCDEYFLEKYPLSQYKYIRSCIMLGR-------MPNLMLMAKESLYSQL----PM---DCFTMPSYSRKS---------------LWVINSALRIKILCAT-------------YVNVNDKIYVRTGIYH--GGEPLCDNVNTQRVPCSNP----------RW--NEWLNYDIYIPDLPRAARLCLSICSVKEEH------------------------------CPLAWGNINLFDYTDTLVSGKMALNLW-----PVPHGLE-----DLLNPIGVTGSNP-N-K-ETPCLELEFDWFS-S-VVKFPDMSVIEEHANWS------VSREAGFSYSHAGLSNRLA-RDNELREND--KEQLKAISTR-DPLSEITEQEKDFLWSHRHYCV-TI-PEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIK-----PEQAMELLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLD----------NLLVRFLLKKAL-TNQRIGHFFFWHLKSEMH-NK--------TVSQRFGLLLESYCRA--C-------G-M------YL-KHLNRQVEAMEKLINL-TDILKQEKK------D--E---TQ-KVQMKF-----LVE---Q-------M---RR------PDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLWLNWEN---PDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLSIGDCVGLIEVVRNSHTIMQIQCKG----------FNSHTLHQWLKDKNKGE-IY----DAAIDLFTRSCAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDR-----------VPFVLTQDFLIVI---S-T---K---TRE-----FERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSF--DDIAYIRKTLALDKTEQEALEYFMKQMNDA------------------
51 Fugue 72.6831% -44 - C3 - - 1E8X PK3CG_PIG A:[1-951] -------------------------AASEETLAFQRQLNALIGY-DVTDVSNVHD---------------------------------------DELEFTRRRLVTPRMAEVAGRD------PKLYAMHPWVTSKPLPEYLLKKIT-------------NNCVFIVIHRSTTS-QTIKVSAD-----------------DTPGTILQSFFTKMA-NERDFVLRVCGRDEYLVGETPIKNFQWVRQCLKNGE-------EIHLVLDTPP----------------------------------------------DPALDEVRKECDRKFRVKIRGIDIPVLPRTADLTVFVEANIQYG----------QQVLCQRRTSPKPFTEEVLW--NVWLEFSIKIKDLPKGALLNLQIYCQ-----------------------------------LLYYVNLLLIDHRFLLRHGEYVLHMW-----QL----S-----GFNADKLTSATNP-DKE-NSMSISILLDNHP-I-ALEMPN--------------------------------------------QL--RKQLEAIIAT-DPLNPLTAEDKELLWHFRYESL-KD-PKAYPKLFSSVKWGQQEIVAKTYQLLAKREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLES-LEDDDVLHYLLQLVQAVKFEPYHD----------SALARFLLKRGLR-NKRIGHFLFWFLRSEIAQSR--------HYQQRFAVILEAYLRGCGT-------A-M------LH-DFT-QQVQVIDMLQKV-TIDIKSLSAEKYDVSS--Q---VI-SQLKQK-----LEN---L-------QNLNLP------QSFRVPY-------DPGLKAGALVIEKCKVMASKKKPLWLEFKCADPTALSNETIG----IIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTV--GNTGA--FKDEVLSHWLKEKCPIEEKF----QAAVERFVYSCAGYCVATFVLGIGDRHNDNIMISETGNLFHIDFGHV---------------PFVLTPDFLFVM---GTSGKKT---SLH-----FQKFQDVCVKAYLALRHHTNLLIILFSMMLMTGMPQLTSK--EDIEYIRDALTVGKSEEDAKKYFLDQIEVCRD-KGWTVQFNWFLHLVL
5 PsiBlast_PDB 72.4633% -38 - C3 - - 5SWP PK3CA_HUMAN A:[278-1082] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YILKVCGCDEYFLEKYPLSQYKYIRSCIMLGR-------MPNLMLMAKESLYSQL----PMDCFTMPSYS----------NGETSTKS---LWVINSALRIKIL---------CATYVNVNIRDIDKIY------VRTGIYHGGEP------LCDNVNTQRVPCSNPRWNEW--LNYDIYIPDLPRAARLCLSICS------V-------EEHCP------------------LAWGNINLFDYTDTLVSGKMALNLW-----PVPHGLE-----DLLNPIGVTGSNP-N-K-ETPCLELEFDWFS-S-VVKFPDM---SVIEEHANWSVSREAGFSYSH---AGLSNRLARDN---ELRENDKEQLKAISTR-DPLSEITEQEKDFLWSHRHYCV-TI-PEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIK-----PEQAMELLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLD----------NLLVRFLLKKAL-TNQRIGHFFFWHLKSEMH-NK--------TVSQRFGLLLESYCRA--C-------G-M------YL-KHLNRQVEAMEKLINL-T-DILKQEK------K--D---ET-QKVQMKFL---VEQ---M-------R---RPDFMDALQGFLSPL-------NPAHQLGNLRLEECRIMSSAKRPLWLNWEN---PDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLSIGDCVGLIEVVRNSHTIMQIQCK-G--GLKGALQFNSHTLHQWLKDKN--KGEIY---DAAIDLFTRSCAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDFLIVI---SKG---A---QECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSF--DDIAYIRKTLALDKTEQEALEYFMKQMNDAHH-GGWTTK---------
9 PsiBlast_PDB 72.3533% -39 - C3 - - 5SXC PK3CA_HUMAN A:[278-1080] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YILKVCGCDEYFLEKYPLSQYKYIRSCIMLGR-------MPNLMLMAKESLYSQL----PMDCFTMPSYS--------------STKS---LWVINSALRIKIL---------CATYVNVNIRDIDKIY------VRTGIYHGGEP------LCDNVNTQRVPCSNPRWNEW--LNYDIYIPDLPRAARLCLSICS------V---------HCP------------------LAWGNINLFDYTDTLVSGKMALNLW-----PVPHGLE-----DLLNPIGVTGSNP-N-K-ETPCLELEFDWFS-S-VVKFPDM---SVIEEHANWSVSREAGFSYSH---AGLSNRLARDN---ELRENDKEQLKAISTR-DPLSEITEQEKDFLWSHRHYCV-TI-PEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIK-----PEQAMELLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLD----------NLLVRFLLKKAL-TNQRIGHFFFWHLKSEMH-NK--------TVSQRFGLLLESYCRA--C-------G-M------YL-KHLNRQVEAMEKLINL-T-DILKQEK------K--D---ET-QKVQMKFL---VEQ---M-------R---RPDFMDALQGFLSPL-------NPAHQLGNLRLEECRIMSSAKRPLWLNWEN---PDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLSIGDCVGLIEVVRNSHTIMQIQCK-G--GLKGALQFNSHTLHQWLKDKN--KGEIY---DAAIDLFTRSCAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKF---RERVPFVLTQDFLIVI---SKG---A---QECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSF--DDIAYIRKTLALDKTEQEALEYFMKQMNDAHH-GGWT-----------
16 PsiBlast_PDB 72.3133% -44 - C3 - - 5SX8 PK3CA_HUMAN A:[278-1082] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YILKVCGCDEYFLEKYPLSQYKYIRSCIMLGR-------MPNLMLMAKESLYSQL----PMDCFTMPSYS----------NGETSTKS---LWVINSALRIKIL---------CATYVNVNIRDIDKIY------VRTGIYHGGEP------LCDNVNTQRVPCSNPRWNEW--LNYDIYIPDLPRAARLCLSICS------V--------EHCP------------------LAWGNINLFDYTDTLVSGKMALNLW-----PVPHGLE-----DLLNPIGVTGSNP-N-K-ETPCLELEFDWFS-S-VVKFPDM---SVIEEHANWSVSREAGFSYSH---AGLSNRLARD------RENDKEQLKAISTR-DPLSEITEQEKDFLWSHRHYCV-TI-PEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIK-----PEQAMELLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLD----------NLLVRFLLKKAL-TNQRIGHFFFWHLKSEMH-NK--------TVSQRFGLLLESYCRA--C-------G-M------YL-KHLNRQVEAMEKLINL-T-DILKQEK------K--D---ET-QKVQMKFL---VEQ---M-------R---RPDFMDALQGFLSPL-------NPAHQLGNLRLEECRIMSSAKRPLWLNWEN---PDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLSIGDCVGLIEVVRNSHTIMQIQCK-G--GLKGALQFNSHTLHQWLKDKN--KGEIY---DAAIDLFTRSCAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDFLIVI---SKG---A---QECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSF--DDIAYIRKTLALDKTEQEALEYFMKQMNDAHH-GGWTTK---------
6 PsiBlast_PDB 72.3033% -40 - C3 - - 5SWR PK3CA_HUMAN A:[278-1080] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YILKVCGCDEYFLEKYPLSQYKYIRSCIMLGR-------MPNLMLMAKESLYSQL----PMDCFTMPSYS------------ETSTKS---LWVINSALRIKIL---------CATYVNVNIRDIDKIY------VRTGIYHGGEP------LCDNVNTQRVPCSNPRWNEW--LNYDIYIPDLPRAARLCLSICS------V-------EEHCP------------------LAWGNINLFDYTDTLVSGKMALNLW-----PVPHGLE-----DLLNPIGVTGSNP-N-K-ETPCLELEFDWFS-S-VVKFPDM---SVIEEHANWSVSREAGFSYSH---AGLSNRLARDN---ELRENDKEQLKAISTR-DPLSEITEQEKDFLWSHRHYCV-TI-PEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIK-----PEQAMELLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLD----------NLLVRFLLKKAL-TNQRIGHFFFWHLKSEMH-NK--------TVSQRFGLLLESYCRA--C-------G-M------YL-KHLNRQVEAMEKLINL-T-DILKQEK------K--D---ET-QKVQMKFL---VEQ---M-------R---RPDFMDALQGFLSPL-------NPAHQLGNLRLEECRIMSSAKRPLWLNWEN---PDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLSIGDCVGLIEVVRNSHTIMQIQCK-G--GLKGALQFNSHTLHQWLKDKN--KGEIY---DAAIDLFTRSCAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDFLIVI---SKG---A---QECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSF--DDIAYIRKTLALDKTEQEALEYFMKQMNDAHH-GGWT-----------
10 PsiBlast_PDB 72.2933% -39 - C3 - - 5SXD PK3CA_HUMAN A:[278-1082] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YILKVCGCDEYFLEKYPLSQYKYIRSCIMLGR-------MPNLMLMAKESLYSQL----PMDCFTMPSYS-------------TSTKS---LWVINSALRIKIL---------CATYVNVNIRDIDKIY------VRTGIYHGGEP------LCDNVNTQRVPCSNPRWNEW--LNYDIYIPDLPRAARLCLSICS------V---------HCP------------------LAWGNINLFDYTDTLVSGKMALNLW-----PVPHGLE-----DLLNPIGVTGSNP-N-K-ETPCLELEFDWFS-S-VVKFPDM---SVIEEHANWSVSREAGFSYSH---AGLSNRLARDN---ELRENDKEQLKAISTR-DPLSEITEQEKDFLWSHRHYCV-TI-PEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIK-----PEQAMELLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLD----------NLLVRFLLKKAL-TNQRIGHFFFWHLKSEMH-NK--------TVSQRFGLLLESYCRA--C-------G-M------YL-KHLNRQVEAMEKLINL-T-DILKQEK------K--D---ET-QKVQMKFL---VEQ---M-------R---RPDFMDALQGFLSPL-------NPAHQLGNLRLEECRIMSSAKRPLWLNWEN---PDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLSIGDCVGLIEVVRNSHTIMQIQCK-G--GLKGALQFNSHTLHQWLKDKN--KGEIY---DAAIDLFTRSCAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFG-KRERVPFVLTQDFLIVI---SKG---A---QECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSF--DDIAYIRKTLALDKTEQEALEYFMKQMNDAHH-GGWTTK---------
8 PsiBlast_PDB 72.1133% -35 - C3 - - 5SXB PK3CA_HUMAN A:[278-1084] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YILKVCGCDEYFLEKYPLSQYKYIRSCIMLGR-------MPNLMLMAKESLYSQL----PMDCFTMPSYS-----------GETSTKS---LWVINSALRIKIL---------CATYVNVNIRDIDKIY------VRTGIYHGGEP------LCDNVNTQRVPCSNPRWNEW--LNYDIYIPDLPRAARLCLSICS------V-------EEHCP------------------LAWGNINLFDYTDTLVSGKMALNLW-----PVPHGLE-----DLLNPIGVTGSNP-N-K-ETPCLELEFDWFS-S-VVKFPDM---SVIEEHANWSVSREAGFSYSH---AGLSNRLARDN---ELRENDKEQLKAISTR-DPLSEITEQEKDFLWSHRHYCV-TI-PEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIK-----PEQAMELLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLD----------NLLVRFLLKKAL-TNQRIGHFFFWHLKSEMH-NK--------TVSQRFGLLLESYCRA--C-------G-M------YL-KHLNRQVEAMEKLINL-T-DILKQEK------K--D---ET-QKVQMKFL---VEQ---M-------R---RPDFMDALQGFLSPL-------NPAHQLGNLRLEECRIMSSAKRPLWLNWEN---PDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLSIGDCVGLIEVVRNSHTIMQIQCK-G--GLKGALQFNSHTLHQWLKDKN--KGEIY---DAAIDLFTRSCAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFG-KRERVPFVLTQDFLIVI---SKG---A---QECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSF--DDIAYIRKTLALDKTEQEALEYFMKQMNDAHH-GGWTTKMD-------
18 PsiBlast_PDB 72.0433% -41 - C3 - - 5SXK PK3CA_HUMAN A:[278-1080] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YILKVCGCDEYFLEKYPLSQYKYIRSCIMLGR-------MPNLMLMAKESLYSQL----PMDCFTMPSYS-----------GETSTKS---LWVINSALRIKIL---------CATYVNVNIRDIDKIY------VRTGIYHGGEP------LCDNVNTQRVPCSNPRWNEW--LNYDIYIPDLPRAARLCLSICS------V-------EEHCP------------------LAWGNINLFDYTDTLVSGKMALNLW-----PVPHGLE-----DLLNPIGVTGSNP-N-K-ETPCLELEFDWFS-S-VVKFPDM---SVIEEHANWSVSREAGFSYSH---AGLSN---RDN---ELRENDKEQLKAISTR-DPLSEITEQEKDFLWSHRHYCV-TI-PEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIK-----PEQAMELLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLD----------NLLVRFLLKKAL-TNQRIGHFFFWHLKSEMH-NK--------TVSQRFGLLLESYCRA--C-------G-M------YL-KHLNRQVEAMEKLINL-T-DILKQEK------K--D---ET-QKVQMKFL---VEQ---M-------R---RPDFMDALQGFLSPL-------NPAHQLGNLRLEECRIMSSAKRPLWLNWEN---PDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLSIGDCVGLIEVVRNSHTIMQIQCK-G--GLKGALQFNSHTLHQWLKDKN--KGEIY---DAAIDLFTRSCAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDFLIVI---SKG---A---QECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSF--DDIAYIRKTLALDKTEQEALEYFMKQMNDAHH-GGWT-----------
11 PsiBlast_PDB 71.6333% -35 - C3 - - 5SXE PK3CA_HUMAN A:[278-1082] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YILKVCGCDEYFLEKYPLSQYKYIRSCIMLGR-------MPNLMLMAKESLYSQL----PMDCFTMPSYS-------------TSTKS---LWVINSALRIKIL---------CATYVNVNIRDIDKIY------VRTGIYHGGEP------LCDNVNTQRVPCSNPRWNEW--LNYDIYIPDLPRAARLCLSICS------V---------HCP------------------LAWGNINLFDYTDTLVSGKMALNLW-----PVPHGLE-----DLLNPIGVTGSNP-N-K-ETPCLELEFDWFS-S-VVKFPDM---SVIEEHANWSVSREAGFSYSH---AGLSNRLARDN---ELRENDKEQLKAISTR-DPLSEITEQEKDFLWSHRHYCV-TI-PEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIK-----PEQAMELLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLD----------NLLVRFLLKKAL-TNQRIGHFFFWHLKSEMH-NK--------TVSQRFGLLLESYCRA--C-------G-M------YL-KHLNRQVEAMEKLINL-T-DILKQEK------K--D---ET-QKVQMKFL---VEQ---M-------R---RPDFMDALQGFLSPL-------NPAHQLGNLRLEECRIMSSAKRPLWLNWEN---PDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLSIGDCVGLIEVVRNSHTIMQIQCK-G--GLKGALQFNSHTLHQWLKDKN--KGEIY---DAAIDLFTRSCAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKK----KRERVPFVLTQDFLIVI---SKG---A---QECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSF--DDIAYIRKTLALDKTEQEALEYFMKQMNDAHH-GGWTTK---------
12 PsiBlast_PDB 71.4733% -30 - C3 - - 5SXI PK3CA_HUMAN A:[278-1084] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YILKVCGCDEYFLEKYPLSQYKYIRSCIMLGR-------MPNLMLMAKESLYSQL----PMDCFTMPSYS--------------STKS---LWVINSALRIKIL---------CATYVNVNIRDIDKIY------VRTGIYHGGEP------LCDNVNTQRVPCSNPRWNEW--LNYDIYIPDLPRAARLCLSICS------V-------EEHCP------------------LAWGNINLFDYTDTLVSGKMALNLW-----PVPHGLE-----DLLNPIGVTGSNP-N-K-ETPCLELEFDWFS-S-VVKFPDM---SVIEEHANWSVSREAGFSYSH---AGLSNRLARDN---ELRENDKEQLKAISTR-DPLSEITEQEKDFLWSHRHYCV-TI-PEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIK-----PEQAMELLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLD----------NLLVRFLLKKAL-TNQRIGHFFFWHLKSEMH-NK--------TVSQRFGLLLESYCRA--C-------G-M------YL-KHLNRQVEAMEKLINL-T-DILKQEK------K--D---ET-QKVQMKFL---VEQ---M-------R---RPDFMDALQGFLSPL-------NPAHQLGNLRLEECRIMSSAKRPLWLNWEN---PDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLSIGDCVGLIEVVRNSHTIMQIQCK-G--GLKGALQFNSHTLHQWLKDKN--KGEIY---DAAIDLFTRSCAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKK---KRERVPFVLTQDFLIVI---SKG---A---QECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSF--DDIAYIRKTLALDKTEQEALEYFMKQMNDAHH-GGWTTKMD-------
22 HHSearch 71.1631% -20 * C3 * - 5VLR PK3CD_HUMAN A:[59-1013] --------------------------------QTAEQQELEDEQRRLCDV---QPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEA---AARRQQLGWEAWLQYSFPLQLEPS------------------LP-NRALLVNVKFEGSE-E-SFTF--QVSTKDVPL-ALMACALRKKAT-------------EDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGL-------TPHLTMVHSSSILAMR----D-------------------------------LWSLEQPFRIELIQGSKVNADE-------------RMKLVVQAGLFHGNEMLCKTVSSSEVS---------VCSEPVWKQ--RLEFDINICDLPRMARLCFALYAVIEKAK---------------------------ADCPIAWANLMLFDYKDQLKTGERCLYMW-----PS----VPDEKGELLNPTGTVRSNP-N-TDSAAALLICLPEVAPH-PVYYPALEKILELGRH---------------------T-----------EEE--QLQLREILE-----GELYEHEKDLVWKLRHEVQEHF-PEALARLLLVTKWNKHEDVAQMLYLLCSWPELP-----VLSALELLDFSFPDCHVGSFAIKSLRK-LTDDELFQYLLQLVQVLKYESYLD----------CELTKFLLDRALAN-RKIGHFLFWHLRSEMH-VP--------SVALRFGLILEAYCRG--S-------THH------MK-VLM-KQGEALSKLKAL-NDFVKLSSQK-----T--PKPQTK-ELMHLC-----MRQEAYL-------E---AL------SHLQSPL-------DPSTLLAEVCVEQCTFMDSKMKPLWIMYSN---EEA---SVG----IIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLN-----------FNKDALLNWLKSKNPG-EAL----DRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNF-----INRERVPFILTYDFVHVI---QQG---KTNNSEK-----FERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCS--KDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKT-----------
15 PsiBlast_PDB 71.0933% -39 - C3 - - 5SWO PK3CA_HUMAN A:[278-1080] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YILKVCGCDEYFLEKYPLSQYKYIRSCIMLGR-------MPNLMLMAKESLYSQL----PMDCFTMPSYS----------NGETSTKS---LWVINSALRIKIL---------CATYVNVNIRDIDKIY------VRTGIYHGGEP------LCDNVNTQRVPCSNPRWNEW--LNYDIYIPDLPRAARLCLSICS------V-------EEHCP------------------LAWGNINLFDYTDTLVSGKMALNLW-----PVPHGLE-----DLLNPIGVTGSNP-N-K-ETPCLELEFDWFS-S-VVKFPDM---SVIEEHANWSVSREAGFSYSH---AGLSNRLARDN---ELRENDKEQLKAISTR-DPLSEITEQEKDFLWSHRHYCV-TI-PEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIK-----PEQAMELLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLD----------NLLVRFLLKKAL-TNQRIGHFFFWHLKSEMH-NK--------TVSQRFGLLLESYCRA--C-------G-M------YL-KHLNRQVEAMEKLINL-T-DILKQEK------K--D---ET-QKVQMKFL---VEQ---M-------R---RPDFMDALQGFLSPL-------NPAHQLGNLRLEECRIMSSAKRPLWLNWEN---PDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLSIGDCVGLIEVVRNSHTIMQIQCK-G--GLKGALQFNSHTLHQWLKDKN--KGEIY---DAAIDLFTRSCAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDFLIVI---SKG---A---QECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSF--DDIAYIRKTLALDKTEQEALEYFMKQMNDAHH-GGWT-----------
20 PsiBlast_PDB 71.0133% -34 - C3 - - 4L23 PK3CA_HUMAN A:[250-1058] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YILKVCGCDEYFLEKYPLSQYKYIRSCIMLGR-------MPNLMLMAKESLYSQL----PMDCFTMPSYS-----------GETSTKS---LWVINSALRIKIL---------CATYVNVNIRDIDKIY------VRTGIYHGGEP------LCDNVNTQRVPCSNPRWNEW--LNYDIYIPDLPRAARLCLSICS------VKG---AKEEHCP------------------LAWGNINLFDYTDTLVSGKMALNLW-----PVPHGLE-----DLLNPIGVTGSNP-N-K-ETPCLELEFDWFS-S-VVKFPDM---SVIEEHANWSVSREA-------------NRLARDN---ELRENDKEQLKAISTR-DPLSEITEQEKDFLWSHRHYCV-TI-PEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIK-----PEQAMELLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLD----------NLLVRFLLKKAL-TNQRIGHFFFWHLKSEMH-NK--------TVSQRFGLLLESYCRA--C-------G-M------YL-KHLNRQVEAMEKLINL-T-DILKQEK------K--D---ET-QKVQMKFL---VEQ---M-------R---RPDFMDALQGFLSPL-------NPAHQLGNLRLEECRIMSSAKRPLWLNWEN---PDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLSIGDCVGLIEVVRNSHTIMQIQCK------------NSHTLHQWLKDKN--KGEIY---DAAIDLFTRSCAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDFLIVI---SKG---A---QECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSF--DDIAYIRKTLALDKTEQEALEYFMKQMNDAHH-GGWTTKMDWI-----
7 PsiBlast_PDB 70.7233% -34 - C3 - - 5SWT PK3CA_HUMAN A:[278-1082] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YILKVCGCDEYFLEKYPLSQYKYIRSCIMLGR-------MPNLMLMAKESLYSQL----PMDCFTMPSYS-----------GETSTKS---LWVINSALRIKIL---------CATYVNVNIRDIDKIY------VRTGIYHGGEP------LCDNVNTQRVPCSNPRWNEW--LNYDIYIPDLPRAARLCLSICS------V-------EEHCP------------------LAWGNINLFDYTDTLVSGKMALNLW-----PVPHGLE-----DLLNPIGVTGSNP-N-K-ETPCLELEFDWFS-S-VVKFPDM---SVIEEHANWSVSREAGFSYSH---AGLSNRLARDN---ELRENDKEQLKAISTR-DPLSEITEQEKDFLWSHRHYCV-TI-PEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIK-----PEQAMELLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLD----------NLLVRFLLKKAL-TNQRIGHFFFWHLKSEMH-NK--------TVSQRFGLLLESYCRA--C-------G-M------YL-KHLNRQVEAMEKLINL-T-DILKQEK------K--D---ET-QKVQMKFL---VEQ---M-------R---RPDFMDALQGFLSPL-------NPAHQLGNLRLEECRIMSSAKRPLWLNWEN---PDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLSIGDCVGLIEVVRNSHTIMQIQCK-G--GLKGALQFNSHTLHQWLKDKN--KGEIY---DAAIDLFTRSCAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFG-KRERVPFVLTQDFLIVI---SKG---A---QECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSF--DDIAYIRKTLALDKTEQEALEYFMKQMNDAHH-GGWTTK---------
14 PsiBlast_PDB 70.0333% -15 - C3 - - 5SWG PK3CA_HUMAN A:[278-1080] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YILKVCGCDEYFLEKYPLSQYKYIRSCIMLGR-------MPNLMLMAKESLYSQL----PMDCFTMPSYS-------------TSTKS---LWVINSALRIKIL---------CATYVNVNIRDIDKIY------VRTGIYHGGEP------LCDNVNTQRVPCSNPRWNEW--LNYDIYIPDLPRAARLCLSICS------V-------EEHCP------------------LAWGNINLFDYTDTLVSGKMALNLW-----PVPHGLE-----DLLNPIGVTGSNP-N-K-ETPCLELEFDWFS-S-VVKFPDM---SVIEEHANWSVSREAGFSYSH---AGLSN----DN---ELRENDKEQLKAISTR-DPLSEITEQEKDFLWSHRHYCV-TI-PEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIK-----PEQAMELLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLD----------NLLVRFLLKKAL-TNQRIGHFFFWHLKSEMH-NK--------TVSQRFGLLLESYCRA--C-------G-M------YL-KHLNRQVEAMEKLINL-T-DILKQEK------K--D---ET-QKVQMKFL---VEQ---M-------R---RPDFMDALQGFLSPL-------NPAHQLGNLRLEECRIMSSAKRPLWLNWEN---PDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLSIGDCVGLIEVVRNSHTIMQIQCK-G--GLKGALQFNSHTLHQWLKDKN--KGEIY---DAAIDLFTRSCAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDFLIVI---SKG---A---QECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSF--DDIAYIRKTLALDKTEQEALEYFMKQMNDAHH-GGWT-----------
17 PsiBlast_PDB 69.1333% -21 - C3 - - 5SXF - PK3CA_HUMAN A:[278-1079] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YILKVCGCDEYFLEKYPLSQYKYIRSCIMLGR-------MPNLMLMAKESLYSQL----PMDCFTMPSYS---------------TKS---LWVINSALRIKIL---------CATYVNVNIRDIDKIY------VRTGIYHGGEP------LCDNVNTQRVPCSNPRWNEW--LNYDIYIPDLPRAARLCLSICS------V---------HCP------------------LAWGNINLFDYTDTLVSGKMALNLW-----PVPHGLE-----DLLNPIGVTGSNP-N-K-ETPCLELEFDWFS-S-VVKFPDM---SVIEEHANWSVSREAGFSYSH---AGL-----------ELRENDKEQLKAISTR-DPLSEITEQEKDFLWSHRHYCV-TI-PEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIK-----PEQAMELLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLD----------NLLVRFLLKKAL-TNQRIGHFFFWHLKSEMH-NK--------TVSQRFGLLLESYCRA--C-------G-M------YL-KHLNRQVEAMEKLINL-T-DILKQEK------K--D---ET-QKVQMKFL---VEQ---M-------R---RPDFMDALQGFLSPL-------NPAHQLGNLRLEECRIMSSAKRPLWLNWEN---PDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLSIGDCVGLIEVVRNSHTIMQIQCK-G--GLK----FNSHTLHQWLKDKN--KGEIY---DAAIDLFTRSCAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKK----KRERVPFVLTQDFLIVI---SKG---A---QECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSF--DDIAYIRKTLALDKTEQEALEYFMKQMNDAHH-GGW------------
4 PsiBlast_PDB 69.0033% -17 - C3 - - 4OVV PK3CA_HUMAN A:[278-1081] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YILKVCGCDEYFLEKYPLSQYKYIRSCIMLGR-------MPNLMLMAKESLYSQL----PMDCFTMPSYS------------ETSTKS---LWVINSALRIKIL---------CATYVNVNIRDIDKIY------VRTGIYHGGEP------LCDNVNTQRVPCSNPRWNEW--LNYDIYIPDLPRAARLCLSICS------V--------EHCP------------------LAWGNINLFDYTDTLVSGKMALNLW-----PVPHGLE-----DLLNPIGVTGSNP-N-K-ETPCLELEFDWFS-S-VVKFPDM---SVIEEHANWSVSREAGFSYSH---AGLS-----DN---ELRENDKEQLKAISTR-DPLSEITEQEKDFLWSHRHYCV-TI-PEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIK-----PEQAMELLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLD----------NLLVRFLLKKAL-TNQRIGHFFFWHLKSEMH-NK--------TVSQRFGLLLESYCRA--C-------G-M------YL-KHLNRQVEAMEKLINL-T-DILKQEK------K--D---ET-QKVQMKFL---VEQ---M-------R---RPDFMDALQGFLSPL-------NPAHQLGNLRLEECRIMSSAKRPLWLNWEN---PDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLSIGDCVGLIEVVRNSHTIMQIQCK-G--GLKGALQFNSHTLHQWLKDKN--KGEIY---DAAIDLFTRSCAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDFLIVI---SKG---A---QECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSF--DDIAYIRKTLALDKTEQEALEYFMKQMNDAHH-GGWTT----------
13 PsiBlast_PDB 68.4333% -15 - C3 - - 5SW8 PK3CA_HUMAN A:[278-1081] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YILKVCGCDEYFLEKYPLSQYKYIRSCIMLGR-------MPNLMLMAKESLYSQL----PMDCFTMPSYSR-----------ETSTKS---LWVINSALRIKIL---------CATYVNV-IRDIDKIY------VRTGIYHGGEP------LCDNVNTQRVPCSN--WNEW--LNYDIYIPDLPRAARLCLSICS------V----------CP------------------LAWGNINLFDYTDTLVSGKMALNLW-----PVPHGLE-----DLLNPIGVTGSNP-N-K-ETPCLELEFDWFS-S-VVKFPDM---SVIEEHANWSVSREAGFSYSH---AG--------N---ELRENDKEQLKAISTR-DPLSEITEQEKDFLWSHRHYCV-TI-PEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIK-----PEQAMELLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLD----------NLLVRFLLKKAL-TNQRIGHFFFWHLKSEMH-NK--------TVSQRFGLLLESYCRA--C-------G-M------YL-KHLNRQVEAMEKLINL-T-DILKQEK------K--D---ET-QKVQMKFL---VEQ---M-------R---RPDFMDALQGFLSPL-------NPAHQLGNLRLEECRIMSSAKRPLWLNWEN---PDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLSIGDCVGLIEVVRNSHTIMQIQCK-G--GLKGALQFNSHTLHQWLKDKN--KGEIY---DAAIDLFTRSCAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKK----KRERVPFVLTQDFLIVI---SKG---A---QECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSF--DDIAYIRKTLALDKTEQEALEYFMKQMNDAHH-GGWTT----------