@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LINJ_16_0310: (2018-07-13 )
MMKPSALDRIHVREDDPKELFEIVESVGIGNFGVVLKARNRATDDIVAIKQVPLSDTDKEDLDTIVKEVEILQECDHPNIVRFYGTYHSMGVLWIVMEYCEGGSVDTAYDLLRRPLSEPLIAYVCRQTLLGLRYLHERHVIHRDIKGSNLLLTKNGQVKLADFGVSTELKHTLSRRNSFIGTALWMAPEALTEKDYDSRADMWSLGITTIELAEGQPPYLGMHIARAVFFIPLNDPPTLQAKERWSPQMNMFIRRLLTKDKELRPSAATMLMDPFVDPSAVASQEEMAAVVEQLLTRRRSMDERRDGNNKGSNTSAMTIVTRTSSVVGAIEGAGEEEGEGVAAIPTDEAAAQWIDEHVAPQRRASPAAGRVVARGGGGAVAAGAAAGDRGAPLGGRLMLLPLLHLEDMSFDALNGGGRTLFCGSTAGVSGCAGTVGGATLSSGGAANGAAGGGPRVGGPGAAQAALDGAYTGDGNGSTTMMASVNRYCHPSHLLPTSGGGGVTPMVSAFPPVYGPPSHEARMAAAAAHGDALAESLHLLGYSAEGVSPLYLRCFETTTLNTVREVFLYNQYLPYTRAVSEAEAKHAQRMKLLCGTVLKNVYAATCESTRNA
Atome Classification :
(23 SA)
.........10....-....20........30........40........50.......-.60........70........80........90........100.......110..-.....120.......130.......140.......150.......160.......170.......180.......-190--.-----...--....200.......210.......220.......230..--.--....240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MMKPSAL
D
R
I
HVRED-
D
P
K
E
L
F
E
I
V
E
S
VGIGN
F
G
V
V
L
K
ARNRATD
D
I
V
A
I
K
QVPLSDT
D
-
K
E
D
L
D
T
I
V
K
E
V
E
I
L
Q
ECDHP
N
I
V
R
F
YG
T
Y
H
S
M
G
V
L
W
I
V
M
E
Y
CEGGSV
D
T
A
Y
D
L
L
R
R-PLSE
P
L
I
A
Y
V
C
R
Q
T
L
L
G
L
R
Y
L
H
E
R
H
V
I
H
RDIKGS
N
L
L
L
TKNG
Q
V
K
L
A
DFGV
S
T
E
L
K
H
T
L
S
R
R
NSFI
G
T
A
L
WMA
P
E
-
A
L---T-----EKD--YDSRAD
M
W
SLG
I
T
T
I
ELAEGQPP
Y
L
G
M
H
I
A
R
A
V
F
F
I
PLN--D--PPTL
Q
A
K
ERWS
P
Q
M
N
M
F
I
R
R
L
LTKDKELRP
S
A
A
T
M
LMDPFV
D
P
S
A
VA
S
Q
E
E
M
A
A
V
V
E
Q
L
L
T
R
RRSMDERRDGNNKGSN
T
S
A
M
T
I
V
T
RT
S
S
V
V
G
AIEGAGEEEGE
G
V
A
AIP
T
D
E
A
A
A
Q
W
I
D
E
HVAPQRRASPAA
G
R
V
V
A
RGGGGAVAAGAAAGDRGAPLG
G
R
L
M
L
L
P
L
LHLEDMSFDALNGGG
R
T
L
F
CGSTAGVSGCAGTVGGATLSSGGAANGAAGGGPRVGGP
G
A
A
Q
A
ALDGAYTGDGNG
S
T
T
M
M
A
S
V
N
RYCHPSHLLPTSGGGGVTP
M
V
SAFPPVYGPP
S
H
E
A
R
M
A
A
AAAH
G
D
A
L
A
E
S
L
H
L
LGYSAEGV
S
P
L
Y
L
R
C
FETT
T
L
N
T
V
R
E
V
F
L
YNQYLP
Y
T
RA
V
S
E
A
E
A
K
H
A
Q
R
M
K
L
L
C
G
T
V
L
K
N
V
Y
A
A
T
C
E
STRNA
2
PsiBlast_PDB
85.56
43%
-104
- C1 -
-
5DH3
1
STK3_HUMAN
A:
[25-303]
-----------------
P
E
E
V
F
D
V
L
E
K
L
G
E
G
S
Y
G
S
V
F
K
A
I
H
K
E
S
G
Q
V
V
A
I
K
Q
V
P
V
-----
E
S
D
L
Q
E
I
I
K
E
I
S
I
M
Q
Q
C
D
S
P
Y
V
V
K
Y
Y
G
S
Y
F
K
N
T
D
L
W
I
V
M
E
Y
C
G
A
G
S
V
S
D
I
I
R
L
R
N
K
-
T
L
I
E
D
E
I
A
T
I
L
K
S
T
L
K
G
L
E
Y
L
H
F
M
R
K
I
H
R
D
I
K
A
G
N
I
L
L
N
T
E
G
H
A
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
M
A
K
R
N
T
V
I
G
T
P
F
W
M
A
P
E
-
V
I
---
Q
-----
E
I
G
--
Y
N
C
V
A
D
I
W
S
L
G
I
T
S
I
E
M
A
E
G
K
P
P
Y
A
D
I
H
P
M
R
A
I
F
M
I
P
T
N
--
P
--
P
P
T
F
R
K
P
E
L
W
S
D
D
F
T
D
F
V
K
K
C
L
V
K
N
P
E
Q
R
A
T
A
T
Q
L
L
Q
H
P
F
I
K
N
A
K
P
V
S
------
I
L
R
D
L
I
T
E
A
M
E
I
K
A
K
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
80.58
48%
-117
- C1 -
-
3COM
-
STK4_HUMAN
A:
[29-281]
--------------------
V
F
D
V
L
E
K
L
G
----
G
S
V
Y
K
A
I
H
K
E
T
G
Q
I
V
A
I
K
Q
V
P
V
-----
E
S
D
L
Q
E
I
I
K
E
I
S
I
M
Q
Q
C
D
S
P
H
V
V
K
Y
Y
G
S
Y
F
K
N
T
D
L
W
I
V
M
E
Y
C
G
A
G
S
V
S
D
I
I
R
L
R
N
K
-
T
L
T
E
D
E
I
A
T
I
L
Q
S
T
L
K
G
L
E
Y
L
H
F
M
R
K
I
H
R
D
I
K
A
G
N
I
L
L
N
T
E
G
H
A
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
M
A
K
R
N
T
V
I
G
T
P
F
W
M
A
P
E
-
V
I
---
Q
-----
E
I
G
--
Y
N
C
V
A
D
I
W
S
L
G
I
T
A
I
E
M
A
E
G
K
P
P
Y
A
D
I
H
P
M
R
A
I
F
M
I
P
T
N
--
P
--
P
P
T
F
R
K
P
E
L
W
S
D
N
F
T
D
F
V
K
Q
C
L
V
K
S
P
E
Q
R
A
T
A
T
Q
L
L
Q
H
P
F
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
79.36
46%
-117
- C1 -
-
4LGD
1
STK3_HUMAN
A:
[24-288]
-----------------
P
E
E
V
F
D
V
L
E
K
L
G
E
G
S
Y
G
S
V
F
K
A
I
H
K
E
S
G
Q
V
V
A
I
K
Q
V
P
V
-----
E
S
D
L
Q
E
I
I
K
E
I
S
I
M
Q
Q
C
D
S
P
Y
V
V
K
Y
Y
G
S
Y
F
K
N
T
D
L
W
I
V
M
E
Y
C
G
A
G
S
V
S
D
I
I
R
L
R
N
K
-
T
L
I
E
D
E
I
A
T
I
L
K
S
T
L
K
G
L
E
Y
L
H
F
M
R
K
I
H
R
N
I
K
A
G
N
I
L
L
N
T
E
G
H
A
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
M
A
K
R
N
T
V
I
G
T
P
F
W
M
A
P
E
-
V
I
---
Q
-----
E
I
G
--
Y
N
C
V
A
D
I
W
S
L
G
I
T
S
I
E
M
A
E
G
K
P
P
Y
A
D
I
H
P
M
R
A
I
F
M
I
P
T
N
--
P
--
P
P
T
F
R
K
P
E
L
W
S
D
D
F
T
D
F
V
K
K
C
L
V
K
N
P
E
Q
R
A
T
A
T
Q
L
L
Q
H
P
F
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
HHSearch
79.26
45%
-90
- C1 -
-
6EIM
3
STK10_HUMAN
B:
[8-282]
-------
Y
E
H
V
R
R
D
L
-
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
T
K
S
---
E
E
E
L
E
D
Y
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
L
D
R
-
G
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
K
T
L
Q
K
R
D
S
F
I
G
T
P
Y
W
M
A
P
E
-
V
V
---
M
C
ETMK
D
T
P
--
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
R
V
L
L
A
I
A
A
S
--
D
--
P
P
T
L
L
T
P
S
K
W
S
V
E
F
R
D
F
L
A
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
76.47
44%
-33
- C1 -
-
3ZHP
-
STK24_HUMAN
C:
[19-279]
----------
Y
F
Q
S
M
-
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
-
D
E
I
-
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
---
A
L
D
L
L
E
P
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
---
R
N
T
F
V
G
T
P
F
W
M
A
P
E
-
V
I
---
K
-----
Q
S
A
--
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
P
K
N
--
N
--
P
P
T
L
E
G
--
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
75.64
46%
-82
- C1 -
-
4BC6
2
STK10_HUMAN
A:
[6-275]
-------------
D
L
-
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
T
K
S
---
E
E
E
L
E
D
Y
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
L
D
R
-
G
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
K
T
L
Q
--------
P
Y
W
M
A
P
E
-
V
V
---
M
C
E
T
M
K
D
T
P
--
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
R
V
L
L
K
I
A
K
S
--
D
--
P
P
T
L
L
T
P
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
75.51
46%
-71
- C1 -
-
5J5T
1
M4K3_HUMAN
A:
[3-268]
------------------
Q
E
D
F
E
L
I
Q
R
I
G
S
G
T
Y
G
D
V
Y
K
A
R
N
V
N
T
G
E
L
A
A
I
K
V
I
K
L
E
P
---
G
E
D
F
A
V
V
Q
Q
E
I
I
M
M
K
D
C
K
H
P
N
I
V
A
Y
F
G
S
Y
L
R
R
D
K
L
W
I
C
M
E
F
C
G
G
G
S
L
Q
D
I
Y
H
V
-
T
G
-
P
L
S
E
L
Q
I
A
Y
V
S
R
E
T
L
Q
G
L
Y
Y
L
H
S
K
G
K
M
H
R
D
I
K
G
A
N
I
L
L
T
D
N
G
H
V
K
L
A
D
F
G
V
S
A
Q
I
T
A
T
I
A
---
A
F
I
G
T
P
Y
W
M
A
P
E
-
V
A
---
A
V
ER--
K
G
G
--
Y
N
Q
L
C
D
L
W
A
V
G
I
T
A
I
E
L
A
E
L
Q
P
P
M
F
D
L
H
P
M
R
A
L
F
L
M
T
K
S
N
F
Q
--
P
P
K
L
K
D
K
M
K
W
S
N
S
F
H
H
F
V
K
M
A
L
T
K
N
P
K
K
R
P
T
A
E
K
L
L
Q
H
P
F
V
T
Q
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
75.42
45%
-19
- C1 -
-
5AJQ
2
STK10_HUMAN
A:
[7-289]
----------
H
V
R
R
D
L
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
--
E
----
E
E
E
L
E
D
Y
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
L
D
R
-
G
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
K
T
------
F
I
G
T
P
Y
W
M
A
P
E
-
V
V
MCE
T
-----
M
K
D
TP
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
R
V
L
L
K
I
A
K
S
--
D
--
P
P
T
L
L
T
P
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
--
S
S
I
T
S
N
K
A
L
R
E
L
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
74.89
45%
-29
- C1 -
-
4AOT
1
STK10_HUMAN
A:
[10-292]
----------
H
V
R
R
D
L
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
--
E
T
K
S
-
E
E
E
L
E
D
Y
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
L
D
R
-
G
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
-------------
G
T
P
Y
W
M
A
P
E
-
V
V
M-------------
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
R
V
L
L
K
I
A
K
S
--
D
--
P
P
T
L
L
T
P
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
--
S
S
I
T
S
N
K
A
L
R
E
L
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
72.80
45%
-73
- C1 -
-
5J5T
1
M4K3_HUMAN
A:
[3-265]
------------------
Q
E
D
F
E
L
I
Q
R
I
G
S
G
T
Y
G
D
V
Y
K
A
R
N
V
N
T
G
E
L
A
A
I
K
V
I
K
L
E
P
G
---
E
D
F
A
V
V
Q
Q
E
I
I
M
M
K
D
C
K
H
P
N
I
V
A
Y
F
G
S
Y
L
R
R
D
K
L
W
I
C
M
E
F
C
G
G
G
S
L
Q
D
I
Y
H
V
-
T
G
-
P
L
S
E
L
Q
I
A
Y
V
S
R
E
T
L
Q
G
L
Y
Y
L
H
S
K
G
K
M
H
R
D
I
K
G
A
N
I
L
L
T
D
N
G
H
V
K
L
A
D
F
G
V
S
A
Q
I
T
A
T
I
A
---
A
F
I
G
T
P
Y
W
M
A
P
E
V
A
A
---
V
-----
E
R
K
GG
Y
N
Q
L
C
D
L
W
A
V
G
I
T
A
I
E
L
A
E
L
Q
P
P
M
F
D
L
H
P
M
R
A
L
F
L
M
T
K
S
--
N
F
Q
P
P
K
L
K
D
K
M
K
W
S
N
S
F
H
H
F
V
K
M
A
L
T
K
N
P
K
K
R
P
T
A
E
K
L
L
Q
H
P
F
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
71.21
37%
-107
- C1 -
-
4XBR
1
INKA1_HUMAN (first)
A:
[90-350]
--------------
G
-
D
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
---
Q
Q
R
R
E
L
L
F
N
E
V
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
--
T
-
R
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
-
L
I
---
S
-----
R
L
P
--
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
R
D
N
--
L
--
P
P
R
L
K
N
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
A
K
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
70.41
46%
-128
- C1 -
-
6AO5
1
STK3_HUMAN
A:
[13-263]
----------------------
D
V
L
E
K
L
G
E
G
S
Y
G
S
V
F
K
A
I
H
-----
V
V
A
I
K
Q
----------
D
L
Q
E
I
I
K
E
I
S
I
M
Q
Q
C
D
S
P
Y
V
V
K
Y
Y
G
S
Y
F
----
L
W
I
V
M
E
Y
C
G
A
G
S
V
S
D
I
I
R
L
R
N
K
-
T
L
I
E
D
E
I
A
T
I
L
K
S
T
L
K
G
L
E
Y
L
H
F
M
R
K
I
H
R
N
I
K
A
G
N
I
L
L
N
T
E
G
H
A
K
L
A
D
F
G
V
A
------------
V
I
G
T
P
F
W
M
A
P
E
-
V
I
---
Q
-----
E
I
G
--
Y
N
C
V
A
D
I
W
S
L
G
I
T
S
I
E
M
A
E
G
K
P
P
Y
A
D
I
H
P
M
R
A
I
F
M
I
P
T
N
--
P
--
P
P
T
F
R
K
P
E
L
W
S
D
D
F
T
D
F
V
K
K
C
L
V
K
N
P
E
Q
R
A
T
A
T
Q
L
L
Q
H
P
F
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
70.38
45%
-13
- C1 -
-
4BC6
2
STK10_HUMAN
A:
[2-284]
----------
H
V
R
R
D
L
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
--
E
T
K
S
-
E
E
E
L
E
D
Y
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
L
D
R
-
G
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
K
T
L
Q
--------
P
Y
W
M
A
P
E
-
V
V
M
C
E
T
-----
M
K
D
TP
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
R
V
L
L
K
I
A
K
S
--
D
--
P
P
T
L
L
T
P
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
--
S
S
I
T
S
N
K
A
L
R
E
L
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
69.32
45%
-8
- C1 -
-
6EIM
5
STK10_HUMAN
A:
[11-292]
-----------
V
R
R
D
L
D
P
N
E
V
W
E
I
V
G
E
L
------
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
--
E
T
K
S
-
E
E
E
L
E
D
Y
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
L
D
R
-
G
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
K
T
L
Q
K
R
D
S
F
I
G
T
P
Y
W
M
A
P
E
-
V
V
M
C
E
T
-----
M
K
D
TP
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
R
V
L
L
A
I
A
A
S
--
D
--
P
P
T
L
L
T
P
S
K
W
S
V
E
F
R
D
F
L
A
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
--
S
S
I
T
S
N
K
A
L
R
E
L
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
68.46
44%
-1
- C1 -
-
4USF
1
SLK_HUMAN
A:
[7-276]
----------
H
V
T
R
D
L
N
P
E
D
F
W
E
I
I
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
---
D
T
K
S
E
E
E
L
E
D
Y
M
V
E
I
D
I
L
A
S
C
D
H
P
N
I
V
K
L
L
D
A
F
Y
Y
E
N
N
L
W
I
L
I
E
F
C
A
G
G
A
V
D
A
V
M
L
E
L
E
R
-
P
L
T
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
K
I
I
H
R
D
L
K
A
G
N
I
L
F
T
L
D
G
D
I
K
L
A
D
F
G
V
S
A
K
-------------
T
P
Y
W
M
A
P
E
-
V
V
M
C
E---------RP
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
H
E
L
N
P
M
R
V
L
L
K
I
A
K
S
--
E
--
P
P
T
L
A
Q
P
S
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
68.25
45%
-10
- C1 -
-
5OWR
1
STK10_HUMAN
A:
[10-292]
----------
H
V
R
R
D
L
D
P
N
E
V
W
E
I
V
G
E
L
G
----
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
--
E
T
K
---
E
E
L
E
D
Y
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
L
D
R
-
G
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
K
T
L
Q
K
-------
P
Y
W
M
A
P
E
-
V
V
M
C
E
T
-----
M
K
D
TP
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
R
V
L
L
K
I
A
K
S
--
D
--
P
P
T
L
L
T
P
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
--
S
S
I
T
S
N
K
A
L
R
E
L
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
68.12
45%
-9
- C1 -
-
4USE
1
STK10_HUMAN
A:
[10-292]
----------
H
V
R
R
D
L
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
--
E
T
K
S
-
E
E
E
L
E
D
Y
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
L
D
R
-
G
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
K
T
L
Q
-------
T
P
Y
W
M
A
P
E
-
V
V
M
C
E
T
-----
M
K
D
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
R
V
L
L
K
I
A
K
S
--
D
--
P
P
T
L
L
T
P
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
--
S
S
I
T
S
N
K
A
L
R
E
L
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
67.11
43%
11
- C1 -
-
2JFL
6
SLK_HUMAN
A:
[28-297]
----------
H
V
T
R
D
L
N
P
E
D
F
W
E
I
I
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
---
D
T
K
S
E
E
E
L
E
D
Y
M
V
E
I
D
I
L
A
S
C
D
H
P
N
I
V
K
L
L
D
A
F
Y
Y
E
N
N
L
W
I
L
I
E
F
C
A
G
G
A
V
D
A
V
M
L
E
L
E
R
-
P
L
T
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
K
I
I
H
R
D
L
K
A
G
N
I
L
F
T
L
D
G
D
I
K
L
A
D
F
G
V
S
A
K
N
T
R
T
I
Q
R
R
D
S
F
I
G
T
P
Y
W
M
A
P
E
-
V
V
MCE
T
-----
S
K
D
RP
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
H
E
L
N
P
M
R
V
L
L
K
I
A
K
S
--
E
--
P
P
T
L
A
Q
P
S
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
66.53
44%
11
- C1 -
-
2J51
5
SLK_HUMAN
A:
[28-297]
----------
H
V
T
R
D
L
N
P
E
D
F
W
E
I
I
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
---
D
T
K
S
E
E
E
L
E
D
Y
M
V
E
I
D
I
L
A
S
C
D
H
P
N
I
V
K
L
L
D
A
F
Y
Y
E
N
N
L
W
I
L
I
E
F
C
A
G
G
A
V
D
A
V
M
L
E
L
E
R
-
P
L
T
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
K
I
I
H
R
D
L
K
A
G
N
I
L
F
T
L
D
G
D
I
K
L
A
D
F
G
V
S
A
K
N
T
R
T
I
Q
R
R
D
S
F
I
G
T
P
Y
W
M
A
P
E
-
V
V
M
CE
T
-----
S
K
D
RP
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
H
E
L
N
P
M
R
V
L
L
K
I
A
K
S
--
E
--
P
P
T
L
A
Q
P
S
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
66.47
45%
-13
- C1 -
-
2J7T
1
STK10_HUMAN
A:
[10-292]
----------
H
V
R
R
D
L
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
--
E
-----
E
E
L
E
D
Y
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
L
D
R
-
G
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
K
T
L
Q
K
-----
G
T
P
Y
W
M
A
P
E
-
V
V
M
C
E
T
-----
M
K
D
TP
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
R
V
L
L
K
I
A
K
S
--
D
--
P
P
T
L
L
T
P
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
--
S
S
I
T
S
N
K
A
L
R
E
L
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
66.22
44%
12
- C1 -
-
2UV2
6
SLK_HUMAN
A:
[28-297]
----------
H
V
T
R
D
L
N
P
E
D
F
W
E
I
I
G
E
L
G
D
--
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
---
D
T
K
S
E
E
E
L
E
D
Y
M
V
E
I
D
I
L
A
S
C
D
H
P
N
I
V
K
L
L
D
A
F
Y
Y
E
N
N
L
W
I
L
I
E
F
C
A
G
G
A
V
D
A
V
M
L
E
L
E
R
-
P
L
T
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
K
I
I
H
R
D
L
K
A
G
N
I
L
F
T
L
D
G
D
I
K
L
A
D
F
G
V
S
A
K
N
T
R
T
I
Q
R
R
D
S
F
I
G
T
P
Y
W
M
A
P
E
-
V
V
M
CE
T
-----
S
K
D
RP
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
H
E
L
N
P
M
R
V
L
L
K
I
A
K
S
--
E
--
P
P
T
L
A
Q
P
S
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
65.05
45%
-22
- C1 -
-
4EQU
2
STK10_HUMAN
A:
[10-292]
----------
H
V
R
R
D
L
D
P
N
E
V
W
E
I
V
G
E
L
G
-----
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
--
E
-------
L
E
D
Y
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
L
D
R
-
G
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
---------
I
G
T
P
Y
W
M
A
P
E
-
V
V
M
C
E
T
-----
M
K
D
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
R
V
L
L
K
I
A
K
S
--
D
--
P
P
T
L
L
T
P
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
--
S
S
I
T
S
N
K
A
L
R
E
L
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
59.00
45%
-26
- C1 -
-
5OWQ
1
STK10_HUMAN
A:
[15-292]
---------------L
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
--
E
----
E
E
E
L
E
D
Y
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
----
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
L
D
R
-
G
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
--------------------
P
Y
W
M
A
P
E
-
V
V
M
C
E-----------
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
R
V
L
L
K
I
A
K
S
--
D
--
P
P
T
L
L
T
P
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
--
S
S
I
T
S
N
K
A
L
R
E
L
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------