@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LINJ_29_2140: (2018-07-13 )
MAQAAYPPSREGSYPHSRSGGPRANPMLPEQMIGSYVIRETIGRGSFGKVKKGRHVHTGEYVAIKILNRQKLKSANMDKKIHREIEILQLFSHPNICRLYEVISTPTDMYLIMEYVEGGELYDYIVQKGRVRESEARYIFQQIVCAIEYCHHFRVVHRDLKPENILLGTGLQVKLIDFGLSNITKDGEFLATSCGSPNYAAPEVISGKLYFGPEVDVWSCGVILYALLCGCLPFDEDSIPLLFSKIKKGKYAIPSNMQTGPRELIQQILVVDPLVRLTVPQIRDNAWFNQRLPMRLSYSESIFSVKEDRILSVLVSETAKRLGVRDRDVRKELELGYGAAFVAYNILLDARRRREIAAEVRELGMSGDESRGVSHVIGAQQTKFQPKATERELNMGLMLTQSPAMVVLLDEEDATRNKWAYNRGCFVPASVATLGDPTKVSDTSLSDGSGNGGPGGSIAVGSFRITSKMCSGSLVGSGSVGSSSYAPGSLRGAAGLTGGSSSYRRAGMQSSTGGTAASQLGANLSDQPRVGSVARKHAMYTAEEEQFIVENNYGWRIGIMTDWRAEQALSAIYDVLRTFKMQWKVVSPFRLLARSTAETWSVMADSTQSRNASTRRNTLSTYSVESSAPIRIGCRSGAPGSGSSDDHEDGDIAGSMQRDEECIHAHITRTRRAGAAARSFGSAPGGGFNTSSSQVARGNYFGGLQGGDEEAAIVSGSAASGVLQSAHAIESGSESTSSPRDPRGASPPASAAASTSAIAEPASSPANPVVISLYFFRIHERHDKGYLVDFKVVRNAMVAADLVLLLSDTLVRKLG
Atome Classification :
(27 SA)
.........10........20........30........40........50........60........70..-----......80........90-........100.......110.......120......-.130.......140.......150-.......160.....--..170.......180....-..-.190.......200.....-----..210.......220.......230.......240.......250.----.----.....260.......270.....-----..280.......290....-----...300------------.......310.......320.......330....--...340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810...
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MAQAAYPPSREGSYPHSRSGGPRANPML
P
E
Q
M
I
G
S
Y
V
I
R
E
T
IGRGSFGKVKKG
R
H
VHTG
E
Y
V
A
I
K
I
L
N
R
Q
K
LK-----SANM
D
K
K
I
H
R
E
I
E
I
L
Q
L
F-SHP
N
I
C
R
L
Y
E
V
ISTPT
D
M
Y
L
I
M
E
Y
VEGG
E
L
Y
D
Y
I
V
QK-GRVR
E
S
E
A
R
Y
I
F
Q
Q
I
V
C
A
I
E
Y
C
H
H
-
F
R
V
V
H
RDLKPE
N
I
L
L--GTG
L
Q
V
K
L
I
DF
G
L
S
NITKD-G
E
-
F
L
A
TSCGSPNYAAPEVISG-----
K
L
Y
FGPEV
D
V
W
S
C
G
V
I
L
Y
A
L
L
C
GCLPFDEDS
I
P
L
L
F
S
K
IKKG
K
Y
AI----P----SNMQT
G
P
R
E
L
I
Q
Q
I
L
V
VD
P
L
V
R
L-----TVPQIRDNAWFNQRL
P
M
R
L
-----SYS
E
S
I
------------
F
SV
K
E
D
R
I
L
S
V
L
V
S
E
T
A
K
RLGVR
D
R
D
V
R
K
E
L
E
LG--Y
G
A
A
F
V
A
Y
N
I
L
L
D
A
R
R
R
R
E
I
A
A
E
V
R
E
LGMSGDESRG
V
S
H
V
IGAQQTKFQPKATERELNM
G
L
M
L
TQSP
A
M
V
V
L
LDEEDATRNKWAYNRGCFVPA
S
V
ATLGDPTKVSDTSLSDGSGNGGPGG
S
I
A
V
G
S
F
R
I
T
S
KMCS
G
S
L
VGSGSVGSSSYAPGSLRGAAGLTGGS
S
S
Y
R
RAGMQSSTGG
T
A
A
S
Q
LGANLSDQPR
V
G
S
V
A
R
K
H
AMYTAEE
E
Q
F
I
V
ENNY
G
W
R
I
G
I
M
TD
W
R
A
E
Q
A
L
S
A
I
Y
D
V
L
R
T
F
K
M
Q
W
K
VV
S
P
F
R
L
L
A
R
STAE
T
W
S
V
MADSTQSRNASTRR
N
T
L
S
T
YSVESSA
P
I
R
I
G
CRSGAPGSGSSDDHEDGDIAGSMQR
D
E
E
C
I
H
A
H
I
T
R
T
RRAGAAARSFGSAPGGGFNTSSSQVARGNYFGGLQGGDE
E
A
A
I
VSGS
A
A
S
G
V
L
Q
S
A
H
AIESGSESTSSPRDPRGASPPASAAASTSAIAEPASSPAN
P
V
V
I
S
L
Y
F
F
R
IHERHDK
G
Y
L
V
D
F
K
V
V
R
N
A
M
V
A
A
D
L
V
L
L
L
S
D
T
L
V
R
KLG
2
PsiBlast_PDB
92.97
52%
-139
- C1 -
-
5EZV
2
AAPK1_HUMAN (first)
A:
[27-449]
--------------------------------
I
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
R
-----
S
L
D
V
V
G
K
I
K
R
E
I
Q
N
L
K
L
F
-
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
-
G
R
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
-
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
--
D
A
H
M
N
A
K
I
A
D
F
G
L
S
N
M
M
S
D
-
G
E
-
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
-----
R
L
Y
A
G
P
E
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
E
H
V
P
T
L
F
K
K
I
R
G
G
V
F
Y
I
----
P
----
E
Y
L
N
R
S
V
A
T
L
L
M
H
M
L
Q
V
D
P
L
K
R
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
Q
D
L
P
S
Y
L
-----
F
P
E
D
P
--------------
S
Y
D
A
N
V
I
D
D
E
A
V
K
E
V
C
E
K
F
E
C
T
E
S
E
V
M
N
S
L
Y
S
G
DP
Q
D
Q
L
A
V
A
Y
H
L
I
I
D
N
R
R
I
M
N
Q
A
S
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
92.30
53%
-137
- C1 -
-
5ISO
2
?
A:
[13-429]
--------------------------------
I
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
R
-----
S
L
D
V
V
G
K
I
K
R
E
I
Q
N
L
K
L
F
-
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
-
G
R
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
-
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
--
D
A
H
M
N
A
K
I
A
D
F
G
L
S
N
M
M
S
D
-
G
E
-
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
-----
R
L
Y
A
G
P
E
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
E
H
V
P
T
L
F
K
K
I
R
G
G
V
F
Y
I
----
P
----
E
Y
L
N
R
S
V
A
T
L
L
M
H
M
L
Q
V
D
P
L
K
R
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
Q
D
L
P
S
Y
L
-----
F
P
E
D
P
--------------
S
Y
D
A
N
V
I
D
D
E
A
V
K
E
V
C
E
K
F
E
C
T
E
S
E
V
M
N
S
L
Y
S
G
DP
Q
D
Q
L
A
V
A
Y
H
L
I
I
D
N
R
R
I
M
N
Q
A
S
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
83.44
50%
-141
- C1 -
-
4RED
-
AAPK1_HUMAN
B:
[13-341]
------------------------------
V
K
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
A
V
A
V
K
I
L
N
R
Q
K
I
R
-----
S
L
D
V
V
G
K
I
R
R
E
I
Q
N
L
K
L
F
-
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
-
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
-
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
--
D
A
H
M
N
A
K
I
A
D
F
G
L
S
N
M
M
S
D
----------
G
S
P
N
Y
A
A
P
E
V
I
S
G
-----
R
L
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
D
H
V
P
T
L
F
K
K
I
C
D
G
I
F
Y
T
----
P
----
Q
Y
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
S
I
K
D
I
R
E
H
E
W
F
K
Q
D
L
P
K
Y
L
-----
F
P
E
D
P
S
--------------
Y
S
T
T
M
I
D
D
E
A
L
K
E
V
C
E
K
F
E
C
S
E
E
E
V
L
S
C
L
Y
N
R
NH
Q
D
P
L
A
V
A
Y
H
L
I
I
D
N
R
R
I
M
N
E
A
K
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
82.95
60%
-141
- C1 -
-
3AQV
1
AAPK2_HUMAN
A:
[10-273]
--------------------------------
I
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
R
-----
S
L
D
V
V
G
K
I
K
R
E
I
Q
N
L
K
L
F
-
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
-
G
R
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
-
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
--
D
A
H
M
N
A
K
I
A
D
F
G
L
S
N
M
M
S
D
-
G
E
-
F
L
------
P
N
Y
A
A
P
E
V
I
S
G
-----
R
L
Y
A
G
P
E
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
E
H
V
P
T
L
F
K
K
I
R
G
G
V
F
Y
I
----
P
----
E
Y
L
N
R
S
V
A
T
L
L
M
H
M
L
Q
V
D
P
L
K
R
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
Q
D
L
P
S
Y
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
82.93
60%
-150
- C1 -
-
2YZA
-
AAPK2_HUMAN
A:
[13-276]
--------------------------------
I
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
R
-----
S
L
D
V
V
G
K
I
K
R
E
I
Q
N
L
K
L
F
-
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
-
G
R
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
-
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
--
D
A
H
M
N
A
K
I
A
D
F
G
L
S
N
M
M
S
D
-------------
N
Y
A
A
P
E
V
I
S
G
-----
R
L
Y
A
G
P
E
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
E
H
V
P
T
L
F
K
K
I
R
G
G
V
F
Y
I
----
P
----
E
Y
L
N
R
S
V
A
T
L
L
M
H
M
L
Q
V
D
P
L
K
R
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
Q
D
L
P
S
Y
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
82.63
60%
-140
- C1 -
-
3AQV
1
AAPK2_HUMAN
A:
[7-273]
-----------------------------
R
V
K
I
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
R
-----
S
L
D
V
V
G
K
I
K
R
E
I
Q
N
L
K
L
F
-
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
-
G
R
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
-
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
--
D
A
H
M
N
A
K
I
A
D
F
G
L
S
N
M
M
S
D
-
G
E
-
F
L
------
P
N
Y
A
A
P
E
V
I
S
G
-----
R
L
Y
A
G
P
E
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
E
H
V
P
T
L
F
K
K
I
R
G
G
V
F
Y
I
----
P
----
E
Y
L
N
R
S
V
A
T
L
L
M
H
M
L
Q
V
D
P
L
K
R
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
Q
D
L
P
S
Y
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
77.53
42%
-116
- C1 -
-
2QNJ
-
MARK3_HUMAN
B:
[48-367]
---------------------------
D
E
Q
P
H
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
R
E
V
A
I
K
I
I
D
K
T
Q
L
N
------
P
T
S
L
Q
K
L
F
R
E
V
R
I
M
K
I
L
-
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
I
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
-
G
R
M
K
E
K
E
A
R
S
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
-
K
R
I
V
H
R
D
L
K
A
E
N
L
L
L
--
D
A
D
M
N
I
K
I
A
D
F
G
F
S
N
E
F
T
-----
K
L
D
T
F
C
G
S
P
P
Y
A
A
P
E
L
F
Q
G
-----
K
K
Y
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
Q
N
L
K
E
L
R
E
R
V
L
R
G
K
Y
R
I
----
P
----
F
Y
M
S
T
D
C
E
N
L
L
K
R
F
L
V
L
N
P
I
K
R
G
-----
T
L
E
Q
I
M
K
D
R
W
I
N
A
G
H
E
E
D
E
-----
L
K
P
F
--------------
V
E
P
E
L
D
I
S
D
Q
K
-
R
I
D
I
M
V
G
M
G
Y
S
Q
E
E
I
Q
E
S
L
S
K
M
K-
Y
D
E
I
T
A
T
Y
L
L
L
G
R
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
76.99
39%
-138
- C1 -
-
5TVT
1
MELK_HUMAN
A:
[6-329]
-----------------------------
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
N
T
L
G
-------
S
D
L
P
R
I
K
T
E
I
E
A
L
K
N
L
-
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
-
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
-
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
--
D
E
Y
H
K
L
K
L
I
D
F
G
L
C
A
K
-------------
G
S
L
A
Y
A
A
P
E
L
I
Q
G
-----
K
S
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
K
Y
D
V
----
P
----
K
W
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
W
I
M
Q
D
Y
N
Y
P
V
-----
E
W
Q
S
K
N
---------------
P
F
I
H
L
D
D
D
C
V
T
E
L
S
V
H
H
R
N
N
R
Q
T
M
E
D
L
I
S
L
W
Q-
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
G
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
76.51
50%
-134
- C1 -
-
4RED
-
AAPK1_HUMAN
A:
[13-341]
------------------------------
V
K
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
A
V
A
V
K
I
L
N
R
Q
K
I
R
-----
S
L
D
V
V
G
K
I
R
R
E
I
Q
N
L
K
L
F
-
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
-
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
-
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
--
D
A
H
M
N
A
K
I
A
D
F
G
L
S
N
M
M
S
D
-----------
S
P
N
Y
A
A
P
E
V
I
S
G
-----
R
L
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
D
H
V
P
T
L
F
K
K
----
I
F
Y
T
----
P
----
Q
Y
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
S
I
K
D
I
R
E
H
E
W
F
K
Q
D
L
P
K
Y
L
-----
F
P
E
D
P
S
--------------
Y
S
T
T
M
I
D
D
E
A
L
K
E
V
C
E
K
F
E
C
S
E
E
E
V
L
S
C
L
Y
N
R
NH
Q
D
P
L
A
V
A
Y
H
L
I
I
D
N
R
R
I
M
N
E
A
K
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
76.16
48%
-127
- C1 -
-
4RER
2
AAPK1_HUMAN
A:
[5-401]
--------------------------------
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
R
-----
S
L
D
V
V
G
K
I
R
R
E
I
Q
N
L
K
L
F
-
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
-
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
-
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
--
D
A
H
M
N
A
K
I
A
D
F
G
L
S
N
M
M
S
D
-
G
E
-
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
-----
R
L
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
D
H
V
P
T
L
F
K
K
I
C
D
G
I
F
Y
T
----
P
----
Q
Y
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
S
I
K
D
I
R
E
H
E
W
F
K
Q
D
L
P
K
Y
L
FPEDP
S
Y
S
---DDEALKEVCEK-
F
E
C
S
E
E
E
V
L
S
C
L
Y
N
R
N
H
Q
-------------------
D
P
L
A
V
A
Y
H
L
I
I
D
N
R
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
76.12
55%
-152
- C1 -
-
3DAE
-
SNF1_YEAST
A:
[52-314]
--------------------------------
I
G
N
Y
Q
I
V
K
T
L
G
E
G
S
F
G
K
V
K
L
A
Y
H
T
T
T
G
Q
K
V
A
L
K
I
I
N
K
K
V
L
A
---------
Q
G
R
I
E
R
E
I
S
Y
L
R
L
L
-
R
H
P
H
I
I
K
L
Y
D
V
I
K
S
K
D
E
I
I
M
V
I
E
Y
A
-
G
N
E
L
F
D
Y
I
V
Q
R
-
D
K
M
S
E
Q
E
A
R
R
F
F
Q
Q
I
I
S
A
V
E
Y
C
H
R
-
H
K
I
V
H
R
D
L
K
P
E
N
L
L
L
--
D
E
H
L
N
V
K
I
A
D
F
------------------
G
S
P
N
Y
A
A
P
E
V
I
S
G
-----
K
L
Y
A
G
P
E
V
D
V
W
S
C
G
V
I
L
Y
V
M
L
C
R
R
L
P
F
D
D
E
S
I
P
V
L
F
K
N
I
S
N
G
V
Y
T
L
----
P
----
K
F
L
S
P
G
A
A
G
L
I
K
R
M
L
I
V
N
P
L
N
R
I
-----
S
I
H
E
I
M
Q
D
D
W
F
K
V
D
L
P
E
Y
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
74.40
39%
-132
- C1 -
-
5K00
1
MELK_HUMAN
A:
[5-326]
------------------------------
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
--
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
N
T
L
G
-------
S
D
L
P
R
I
K
T
E
I
E
A
L
K
N
L
-
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
-
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
-
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
--
D
E
Y
H
K
L
K
L
I
D
F
G
L
C
A
K
P
-------------
S
L
A
Y
A
A
P
E
L
I
Q
G
-----
K
S
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
K
Y
D
V
----
P
----
K
W
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
W
I
M
Q
D
Y
N
Y
P
V
-----
E
W
Q
S
K
N
---------------
P
F
I
H
L
D
D
D
C
V
T
E
L
S
V
H
H
R
N
N
R
Q
T
M
E
D
L
I
S
L
W
Q-
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
73.99
42%
-113
- C- -
-
3FE3
-
MARK3_HUMAN
B:
[50-366]
-----------------------------
Q
P
H
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
R
E
V
A
I
K
I
I
D
K
T
Q
L
------
N
P
T
S
L
Q
K
L
F
R
E
V
R
I
M
K
I
L
-
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
I
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
-
G
R
M
K
E
K
E
A
R
S
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
-
K
R
I
V
H
R
D
L
K
A
E
N
L
L
L
--
D
A
D
M
N
I
K
I
A
D
F
G
F
S
N
E
F
T
V
-
G
G
-
K
L
D
A
F
C
G
A
P
P
Y
A
A
P
E
L
F
Q
G
-----
K
K
Y
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
Q
N
L
K
E
L
R
E
R
V
L
R
G
K
Y
R
I
----
P
----
F
Y
M
S
T
D
C
E
N
L
L
K
R
F
L
V
L
N
P
I
K
R
G
-----
T
L
E
Q
I
M
K
D
R
W
I
N
A
G
H
E
E
D
E
-----
L
K
P
F
--------------
V
E
P
E
L
D
I
S
D
Q
K
-
R
I
D
I
M
V
G
M
G
Y
S
Q
E
E
I
Q
E
S
L
S
K
M
K-
Y
D
E
I
T
A
T
Y
L
L
L
G
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
73.00
55%
-157
- C1 -
-
3HYH
-
SNF1_YEAST
A:
[54-314]
----------------------------------
N
Y
Q
I
V
K
T
L
G
E
G
---
K
V
K
L
A
Y
H
T
T
T
G
Q
K
V
A
L
K
I
I
N
K
K
-----------
M
Q
G
R
I
E
R
E
I
S
Y
L
R
L
L
-
R
H
P
H
I
I
K
L
Y
D
V
I
K
S
K
D
E
I
I
M
V
I
E
Y
A
-
G
N
E
L
F
D
Y
I
V
Q
R
-
D
K
M
S
E
Q
E
A
R
R
F
F
Q
Q
I
I
S
A
V
E
Y
C
H
R
-
H
K
I
V
H
R
D
L
K
P
E
N
L
L
L
--
D
E
H
L
N
V
K
I
A
D
F
G
L
S
-----------------
P
N
Y
A
A
P
E
V
I
S
G
-----
K
L
Y
A
G
P
E
V
D
V
W
S
C
G
V
I
L
Y
V
M
L
C
R
R
L
P
F
D
D
E
S
I
P
V
L
F
K
N
I
S
N
G
V
Y
T
L
----
P
----
K
F
L
S
P
G
A
A
G
L
I
K
R
M
L
I
V
N
P
L
N
R
I
-----
S
I
H
E
I
M
Q
D
D
W
F
K
V
D
L
P
E
Y
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
72.32
49%
-131
- C1 -
-
4RED
-
AAPK1_HUMAN
A:
[15-334]
--------------------------------
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
A
V
A
V
K
I
L
N
R
Q
K
I
R
-----
S
L
D
V
V
G
K
I
R
R
E
I
Q
N
L
K
L
F
-
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
-
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
-
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
--
D
A
H
M
N
A
K
I
A
D
F
G
L
S
N
M
M
S
D
-----------
S
P
N
Y
A
A
P
E
V
I
S
G
-----
R
L
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
D
H
V
P
T
L
F
K
K
----
I
F
Y
T
----
P
----
Q
Y
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
S
I
K
D
I
R
E
H
E
W
F
K
Q
D
L
P
K
Y
L
FPEDP
S
Y
S
T
T
M
ID
D
E
A
L
K
E
V
C
E
K
F
E
C
S
E
E
E
V
L
S
C
L
Y
N
R
N
H
Q
-------------------
D
P
L
A
V
A
Y
H
L
I
I
D
N
R
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
HHSearch
71.62
54%
-158
- C1 -
-
3HYH
-
SNF1_YEAST
A:
[54-312]
----------------------------------
N
Y
Q
I
V
K
T
L
G
E
---
G
K
V
K
L
A
Y
H
T
T
T
G
Q
K
V
A
L
K
I
I
N
K
K
-----------
M
Q
G
R
I
E
R
E
I
S
Y
L
R
L
L
-
R
H
P
H
I
I
K
L
Y
D
V
I
K
S
K
D
E
I
I
M
V
I
E
Y
A
G
N
-
E
L
F
D
Y
I
V
Q
R
-
D
K
M
S
E
Q
E
A
R
R
F
F
Q
Q
I
I
S
A
V
E
Y
C
H
R
-
H
K
I
V
H
R
D
L
K
P
E
N
L
L
L
--
D
E
H
L
N
V
K
I
A
D
F
G
L
S
-----------------
P
N
Y
A
A
P
E
V
I
S
G
-----
K
L
Y
A
G
P
E
V
D
V
W
S
C
G
V
I
L
Y
V
M
L
C
R
R
L
P
F
D
D
E
S
I
P
V
L
F
K
N
I
S
N
G
V
Y
T
L
----
P
----
K
F
L
S
P
G
A
A
G
L
I
K
R
M
L
I
V
N
P
L
N
R
I
-----
S
I
H
E
I
M
Q
D
D
W
F
K
V
D
L
P
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
71.19
50%
-129
- C1 -
-
2QNJ
-
MARK3_HUMAN
A:
[53-308]
--------------------------------
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
R
E
V
A
I
K
I
I
D
K
T
Q
L
N
-----
P
T
S
L
-
Q
K
L
F
R
E
V
R
I
M
K
I
L
-
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
I
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
-
G
R
M
K
E
K
E
A
R
S
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
-
K
R
I
V
H
R
D
L
K
A
E
N
L
L
L
--
D
A
D
M
N
I
K
I
A
D
F
G
F
S
N
E
F
T
-------
D
T
F
C
G
S
P
P
Y
A
A
P
E
L
F
Q
G
-----
K
K
Y
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
Q
N
L
K
E
L
R
E
R
V
L
R
G
K
Y
R
I
----
P
----
F
Y
M
S
T
D
C
E
N
L
L
K
R
F
L
V
L
N
P
I
K
R
G
-----
T
L
E
Q
I
M
K
D
R
W
I
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
68.46
49%
-142
- C1 -
-
5KZ8
1
MARK2_HUMAN
A:
[32-287]
--------------------------------
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
I
D
K
T
Q
L
N
-----
S
S
S
L
-
Q
K
L
F
R
E
V
R
I
M
K
V
L
-
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
-
G
R
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
-
K
F
I
V
H
R
D
L
K
A
E
N
L
L
L
--
D
A
D
M
N
I
K
I
A
D
F
G
----------------
C
G
S
P
P
Y
A
A
P
E
L
F
Q
G
-----
K
K
Y
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
Q
N
L
K
E
L
R
E
R
V
L
R
G
K
Y
R
I
----
P
----
F
Y
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
R
G
-----
T
L
E
Q
I
M
K
D
R
W
M
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
67.68
48%
-151
- C1 -
-
1ZMV
-
MARK2_RAT
A:
[51-305]
---------------------------------
G
N
Y
R
L
L
K
T
I
G
K
G
--
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
R
I
I
D
K
T
Q
L
N
-----
S
S
S
L
-
Q
K
L
F
R
E
V
R
I
M
K
V
L
-
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
-
G
R
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
-
K
F
I
V
H
R
D
L
K
A
E
N
L
L
L
--
D
A
D
M
N
I
K
I
A
--------------------
G
S
P
P
Y
A
A
P
E
L
F
Q
G
-----
K
K
Y
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
Q
N
L
K
E
L
R
E
R
V
L
R
G
K
Y
R
I
----
P
----
F
Y
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
R
G
-----
T
L
E
Q
I
M
K
D
R
W
M
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
66.43
49%
-124
- C- -
-
3FE3
-
MARK3_HUMAN
A:
[53-308]
--------------------------------
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
R
E
V
A
I
K
I
I
D
K
T
Q
L
N
-----
P
T
S
L
-
Q
K
L
F
R
E
V
R
I
M
K
I
L
-
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
I
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
-
G
R
M
K
E
K
E
A
R
S
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
-
K
R
I
V
H
R
D
L
K
A
E
N
L
L
L
--
D
A
D
M
N
I
K
I
A
D
F
G
F
S
N
E
F
T
V
-
G
G
-
K
L
D
A
F
C
G
A
P
P
Y
A
A
P
E
L
F
Q
G
-----
K
K
Y
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
Q
N
L
K
E
L
R
E
R
V
L
R
G
K
Y
R
I
----
P
----
F
Y
M
S
T
D
C
E
N
L
L
K
R
F
L
V
L
N
P
I
K
R
G
-----
T
L
E
Q
I
M
K
D
R
W
I
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
65.99
49%
-150
- C1 -
-
5KZ7
1
MARK2_HUMAN
A:
[32-287]
--------------------------------
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
I
D
K
T
Q
L
N
-----
S
S
S
L
-
Q
K
L
F
R
E
V
R
I
M
K
V
L
-
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
-
G
R
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
-
K
F
I
V
H
R
D
L
K
A
E
N
L
L
L
--
D
A
D
M
N
I
K
I
A
D
F
------------------
G
S
P
P
Y
A
A
P
E
L
F
Q
G
-----
K
--
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
--
N
L
K
E
L
R
E
R
V
L
R
G
K
Y
R
I
----
P
----
F
Y
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
R
G
-----
T
L
E
Q
I
M
K
D
R
W
M
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
HHSearch
64.98
31%
-122
- C1 -
-
5ORV
2
AURKA_HUMAN
A:
[3-261]
-------------------------------
A
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
-----
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
-
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
--
G
S
A
G
E
L
K
I
A
D
F
G
W
S
V
H
A
P
S
-
S
--
R
R
T
T
L
A
G
T
L
D
Y
L
P
P
E
M
I
E
G
-----
R
M
-
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
----
P
----
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
64.47
49%
-129
- C1 -
-
5EAK
1
MARK2_HUMAN
A:
[14-269]
--------------------------------
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
I
D
K
T
Q
L
N
-----
S
S
S
L
-
Q
K
L
F
R
E
V
R
I
M
K
V
L
-
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
-
G
R
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
-
K
F
I
V
H
R
D
L
K
A
E
N
L
L
L
--
D
A
D
M
N
I
K
I
A
D
F
G
F
S
-------------
F
C
G
S
P
P
Y
A
A
P
E
L
F
Q
G
-----
K
K
Y
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
Q
N
L
K
E
L
R
E
R
V
L
R
G
K
Y
R
I
----
P
----
F
Y
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
R
G
-----
T
L
E
Q
I
M
K
D
R
W
M
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
56.59
32%
-51
- C1 -
-
4GV1
5
AKT1_HUMAN
A:
[6-277]
-------------------------------
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
A
T
G
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
-----
A
K
D
E
V
A
H
T
L
T
E
N
R
V
L
Q
N
S
-
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
-
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
--
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
A
-
T
M
K
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
-----
N
D
-
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
E
K
L
F
E
L
I
L
M
E
E
I
R
F
----
P
----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
GGGS
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
51.44
32%
-94
- C1 -
-
4JXF
2
PLK4_HUMAN
A:
[4-264]
------------------------------
E
K
I
E
D
F
K
V
G
N
L
L
G
K
G
S
F
A
G
V
Y
R
A
E
S
I
H
T
G
L
E
V
A
I
K
M
I
D
K
K
A
M
Y
-----
K
A
G
M
V
Q
R
V
Q
N
E
V
K
I
H
C
Q
L
-
K
H
P
S
I
L
E
L
Y
N
Y
F
E
D
S
N
Y
V
Y
L
V
L
E
M
C
H
N
G
E
M
N
R
Y
L
K
N
R
V
K
P
F
S
E
N
E
A
R
H
F
M
H
Q
I
I
T
G
M
L
Y
L
H
S
-
H
G
I
L
H
R
D
L
T
L
S
N
L
L
L
--
T
R
N
M
N
I
K
I
A
D
F
G
L
A
T
Q
L
K
M
-
P
H
E-------------------------------
S
D
V
W
S
L
G
C
M
F
Y
T
L
L
I
G
R
P
P
F
----
V
K
N
T
L
N
K
V
V
L
A
D
Y
E
M
----
P
----
S
F
L
S
I
E
A
K
D
L
I
H
Q
L
L
R
R
N
P
A
D
R
L
-----
S
L
S
S
V
L
D
H
P
F
M
S
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
47.43
35%
-22
- C1 -
-
2Y7J
1
PHKG2_HUMAN
C:
[91-365]
------------------------------
E
F
Y
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
E
V
T
A
E
R
LSPEQ
L
E
E
V
R
E
A
T
R
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
-
V
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
-
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
--
D
D
N
M
Q
I
R
L
S
D
F
G
F
S
C
H
L
E
P
-
G
E
-
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
C
SMDET
H
P
G
Y
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
R
R
Q
I
L
M
L
R
M
I
M
E
G
Q
Y
Q
F
----
S
SPEW
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
-----
T
A
E
Q
A
L
Q
H
P
F
F
E
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
HHSearch
45.03
31%
-59
- C1 -
-
2X4F
4
MYLK4_HUMAN
A:
[89-350]
---------------------------------
Y
T
V
S
K
T
E
I
L
G
-----
Q
V
H
K
C
E
E
T
A
T
G
L
K
L
A
A
K
I
I
K
T
R
G
M
--------
K
D
K
E
E
V
K
N
E
I
S
V
M
N
Q
L
-
D
H
A
N
L
I
Q
L
Y
D
A
F
E
S
K
N
D
I
V
L
V
M
E
Y
V
D
G
G
E
L
F
D
R
I
I
D
E
S
Y
N
L
T
E
L
D
T
I
L
F
M
K
Q
I
C
E
G
I
R
H
M
H
Q
-
M
Y
I
L
H
L
D
L
K
P
E
N
I
L
C
VN
R
D
A
K
Q
I
K
I
I
D
F
G
L
A
R
R
Y
K
P
-
R
E
-
K
L
K
V
N
F
G
T
P
E
F
L
A
P
E
V
V
N
Y
-----
D
F
-
V
S
F
P
T
D
M
W
S
V
G
V
I
A
Y
M
L
L
S
G
L
S
P
F
L
G
D
N
D
A
E
T
L
N
N
I
L
A
C
R
W
D
L
EDEE
F
----
Q
D
I
S
E
E
A
K
E
F
I
S
K
L
L
I
K
E
K
S
W
R
I
-----
S
A
S
E
A
L
K
H
P
W
L
S
D
H
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------