@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LINJ_32_0270: (2018-07-13 )
MDKYQRVKVLGKGSFGSAILIKRKTDGLLFVVKEVGMTRMSKKERDEARHECTVLQQLQHPNIVRYVEQFENNNNLYIVMEYCDGGDLAEKVKHSRGPMKESSMLYYFSQICLAIEYLHARHILHRDIKTMNVFLMKNGAVKLGDFGISTVLRTTMGMANTVCGTPYYFSPELCRNRPYNNKSDIWALGVLLYECATGGRHPFDGTSMNQLMQRIVQGHYAPLSSQYSSDFRKMVDWCLQKDPAKRPSIKQTLALPLMRRSLEQLEENLMLATQCRVRLKDIIDFEGGMDQEERKGSSPQPSPKLSPRAVAKDGVSPGQAAALAMARQNLSPVFQPPTTPSHSPMASPERGGGAPAAVGPKPSAAVPQSPTASPKQGNEAHRFYSPCQKRPIANPLLPGGGARPAPAESPSGAVPPPLAQRPLEEPHHTPPLRIKVTLGGAGDRRGLAAAALPAAAAAPAPGPSPNAADAFHADMRRVDAIIARYGRNSDEKAKETIHAYMRRKHEAYLKRQKEEIEARERRNRMRKEELRRVLENQRMAVSPLRNNDPRNSPHLNNINMNGYPDDRSPRRGSPQPRAKPENVHLPSRSPPSSPLQDKEPVSARTPTNAEPAVFGRDPRRGAPPGEPASRPTTPQQQRVLQQPPSPAAAAPNGNPLPQTPPRRVLYAANSPQQAHPPSQNRTEAPEARRAVTPDPLHSPPSRLGAPRGAAFDIDRRSLPNSKPEAASGGQKAPLTAGLGGGIDGHRMVLQTSQQHLPQPRRPMDAEQLPARRDRRESRVLEDAAVGRRPSALSPISGDPHDHCSPSQAAAAAPERASLSAGDPRLQRPGRALQRYLKPLGGRGEDGVSPLPSPTSAQSPRRGAAGVDRGHRGSSGVPPPVKSKALVSAGNANPPSSAPGELADIPRTAAHSTRAQASPCTPVKEALRALRRSKVQAGAPAPPPSSAMAAGMKDLPAIITSPEHERGARRNHPRYRLEEAALYRGMRREQPSREDERVLVDEHRKPHHAEVSAVPNTLEALRSLRAQQDKAMRAEGGAREEVNPGGQLALLKQRQRMQQRPRQGSTSSSASVPLAPRLMTRATEAAASPRSEVPSGYDRKTPVPRDNAAARPSAAHVTALSLGDVNRGAAPSRAAPPSAHAGAPPSPKPSTGGGAGVQSSMEGYAEMLQHLKDLLQRRRVSSAGGASAPTSPTTAASALSAIENPRDPGARSPISMRNRALPPPLNPSPLGGVDMSCASDSGDSGVLVSPPHLKATRPLHPQPNAVPVVNVRPGCDAEEEDDDDFEDAVPLSPVRCTELNDAYARQQDQQEQKWRHAQEDVYTSDVDLTSAAMEEELEGEEGYTDYHKRPSSKELPKGIKS
Atome Classification :
(27 SA)
------------------------------------------------------------------------.........10........20........30........40.---......-..50........60........70-.........80........90--......---...-100.......110.......120.-----.......130......---.140.......150.......160-.......170...---..-----.-.180.......190..-.....200...-....210.......----------------------------220---........230.......240.....-----..250.......260.......270.......280.......290.-......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310......1320......1330......1340......1350......1360
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
------------------------------------------------------------------------MDK
Y
Q
R
V
K
V
L
GKGSFG
S
A
I
L
I
K
RKTD
G
L
L
F
V
V
K
E
V
G
M
T
R
M
-
S
---
K
K
E
R
D
E
-
A
R
H
E
C
T
V
L
Q
Q
LQH
P
N
I
V
R
Y
V
E
Q
F--ENNN
N
L
Y
I
V
M
E
YCDGG
D
L
A
E
---
K
V
K
HSR---GPM-
K
E
S
S
M
L
Y
Y
F
S
Q
I
C
L
A
I
E
Y
L
H
A
-
R
H
-----
I
L
H
R
D
I
K
T
M
N
V
F
L
MKN---G
A
V
K
L
G
D
F
G
I
S
T
V
L
R
T
T
MGMANTV-CGTPYYF
S
P
E
L
CR---NR-----P-YNNK
S
D
I
W
A
L
G
V
L
L
Y
E
-CATGGRHPFDG-T
S
M
N
Q
L
M
Q
R
I
V
Q
GH----------------------------YA----P
L
S
S
Q
Y
S
S
D
F
R
K
M
V
D
W
C
LQKDPAKRP-----
S
I
K
Q
T
L
A
L
P
L
M
R
R
S
L
E
Q
L
E
E
N
L
M
L
A
T
Q
C
R
V
R
L
K
D
I
IDFEGGM
D
Q
E
E
-RKGSSPQPSPKLS
P
R
A
V
AKDGVSP
G
Q
A
A
A
L
A
M
A
R
QNLSPVFQPPTTPSHSPMASPERGGGAPAAVGPKPSAAVPQSPTASPKQGN
E
A
HRFYS
P
C
QKRPIANPLLPGGGARPAPAESPSGAVPPPLAQRPLEEPHHTP
P
L
R
I
K
V
T
LGGAGDRRG
L
A
A
AALPAAAAAPAPGPSPNA
A
D
A
F
H
A
D
M
R
R
V
D
A
I
I
A
RYGRNS
D
E
K
A
K
E
T
I
H
A
Y
M
R
R
K
H
E
A
Y
L
K
R
Q
K
E
E
I
E
A
R
E
R
R
N
RM
R
K
E
E
L
R
R
V
L
ENQRMAVSPLRNNDPRNSPHLNNINMNGYPDDRSPRRGSPQPRAKPENVHLPSRSPPSSPLQDKEPVSARTPTNAEPAVFGRDPRRGAPPGEPASRPT
T
P
Q
Q
Q
R
V
L
QQPPSPAAAAPNGNPLPQTPP
R
R
V
L
Y
AANSPQQAHPPSQNRTEAPEARRAVTPDPLHS
P
P
S
RLGAPRG
A
A
FDI
D
R
RSLPNSKPEAASGGQKAPLTAGLGGGIDG
H
R
M
V
L
QT
S
Q
Q
HLPQPRRPM
D
A
E
QL
P
A
R
R
D
R
R
E
S
R
V
L
E
D
A
AVGRRPSALSPISGDPHDHCSP
S
Q
A
AAAAPERASLSAGDPRLQR
P
G
R
A
L
Q
R
Y
L
K
PLGGRGEDGVSPLPSPTSAQSPRRGAAGVDRGHRGSSGVPPPVKS
K
A
L
V
SAGNANPPSSAPGELADIPRTAAHSTRAQASPCT
P
V
K
E
A
L
R
A
L
R
RSKVQAGAPAPP
P
S
S
A
M
A
A
G
M
K
D
L
P
A
I
ITSP
E
H
ERGARRNHP
R
Y
R
L
E
E
A
A
L
Y
R
G
M
RREQPSRED
E
R
V
L
V
D
EHRKPHHA
E
V
SAV
P
N
T
L
E
A
L
R
S
L
R
A
Q
Q
D
K
A
MRAEGGAREEVNPG
G
Q
L
A
L
L
K
Q
R
Q
R
M
Q
QRPRQGSTSSSASVPL
A
P
R
L
M
T
R
A
T
EAAASPRSEVPSGYDRKTPVPRDNAAARPSA
A
H
V
T
A
L
S
LGDVNRGAAPSRAAPPSAHAGAPPSPKPSTGGGA
G
V
Q
S
S
M
E
G
Y
A
E
M
L
Q
H
L
K
D
L
L
Q
R
RRVSSAGGASAPTSP
T
T
A
A
S
A
L
S
A
IENPRDPGARSP
I
S
MRNRALPPPLNPSPLGG
V
D
M
SCASDSGDS
G
V
L
VSPPHLKATRPLHPQPNA
V
P
V
V
N
VRPGCDAEEEDDDDFEDAVPLSP
V
R
CTEL
N
D
A
Y
A
R
Q
Q
D
Q
Q
E
Q
K
W
R
H
A
Q
EDVYTSDVD
L
T
S
A
A
M
E
E
ELEGEEGY
T
D
YHKRP
S
S
K
E
LPKGIKS
34
HHSearch
82.72
49%
-54
- C1 -
-
4B9D
2
NEK1_HUMAN
B:
[24-284]
-------------------------------------------------------------------------
E
K
Y
V
R
L
Q
K
I
G
-----
K
A
I
L
V
K
S
T
E
D
G
R
Q
Y
V
I
K
E
I
N
I
S
R
M
-
S
---
S
K
E
R
E
E
-
S
R
R
E
V
A
V
L
A
N
M
K
H
P
N
I
V
Q
Y
R
E
S
F
--
E
E
N
G
S
L
Y
I
V
M
D
Y
C
E
G
G
D
L
F
K
---
R
I
N
A
Q
K
G--
V
L
F
-
Q
E
D
Q
I
L
D
W
F
V
Q
I
C
L
A
L
K
H
V
H
D
-
R
K
-----
I
L
H
R
D
I
K
S
Q
N
I
F
L
T
K
D
---
G
T
V
Q
L
G
D
F
G
I
A
R
V
L
N
S
T
V
E
L
A
R
A
C
-
I
G
T
P
Y
Y
L
S
P
E
I
C
E
---
N
K
-----
P
-
Y
N
N
K
S
D
I
W
A
L
G
C
V
L
Y
E
-
L
C
T
L
-
K
H
A
F
E
A
-
G
S
M
K
N
L
V
L
K
I
I
S
G
S
----------------------------
F
P
----
P
V
S
L
H
Y
S
Y
D
L
R
S
L
V
S
Q
L
F
K
R
N
P
R
D
R
P
-----
S
V
N
S
I
L
E
K
G
F
I
A
K
R
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
HHSearch
81.71
49%
-53
- C1 -
-
4APC
-
NEK1_HUMAN
B:
[24-284]
-------------------------------------------------------------------------
E
K
Y
V
R
L
Q
K
I
G
-----
K
A
I
L
V
K
S
T
E
D
G
R
Q
Y
V
I
K
E
I
N
I
S
R
M
-
S
---
S
K
E
R
E
E
-
S
R
R
E
V
A
V
L
A
N
M
K
H
P
N
I
V
Q
Y
R
E
S
F
--
E
E
N
G
S
L
Y
I
V
M
D
Y
C
E
G
G
D
L
F
K
---
R
I
N
A
Q
K
G--
V
L
F
-
Q
E
D
Q
I
L
D
W
F
V
Q
I
C
L
A
L
K
H
V
H
D
-
R
K
-----
I
L
H
R
D
I
K
S
Q
N
I
F
L
T
K
D
---
G
T
V
Q
L
G
D
F
G
I
A
R
V
L
N
S
T
V
E
L
A
R
A
C
-
I
G
T
P
Y
Y
L
S
P
E
I
C
E
---
N
K
-----
P
-
Y
N
N
K
S
D
I
W
A
L
G
C
V
L
Y
E
-
L
C
T
L
-
K
H
A
F
E
A
-
G
S
M
K
N
L
V
L
K
I
I
S
G
S
----------------------------
F
P
----
P
V
S
L
H
Y
S
Y
D
L
R
S
L
V
S
Q
L
F
K
R
N
P
R
D
R
P
-----
S
V
N
S
I
L
E
K
G
F
I
A
K
R
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
79.76
47%
-47
- C1 -
-
4APC
-
NEK1_HUMAN
A:
[23-296]
------------------------------------------------------------------------
M
E
K
Y
V
R
L
Q
K
I
------
K
A
I
L
V
K
S
T
E
D
G
R
Q
Y
V
I
K
E
I
N
I
S
R
M
-
S
---
S
K
E
R
E
E
-
S
R
R
E
V
A
V
L
A
N
M
K
H
P
N
I
V
Q
Y
R
E
S
F
--
E
E
N
G
S
L
Y
I
V
M
D
Y
C
E
G
G
D
L
F
K
---
R
I
N
A
Q
K
---
G
V
L
F
Q
E
D
Q
I
L
D
W
F
V
Q
I
C
L
A
L
K
H
V
H
D
-
R
K
-----
I
L
H
R
D
I
K
S
Q
N
I
F
L
T
K
D
---
G
T
V
Q
L
G
D
F
G
I
A
R
V
L
N
S
T
V
E
L
A
R
A
C
-
I
G
T
P
Y
Y
L
S
P
E
I
C
E
---
N
K
-----
P
-
Y
N
N
K
S
D
I
W
A
L
G
C
V
L
Y
E
-
L
C
T
-
L
K
H
A
F
E
A
-
G
S
M
K
N
L
V
L
K
I
I
S
G
S
----------------------------
F
P
----
P
V
S
L
H
Y
S
Y
D
L
R
S
L
V
S
Q
L
F
K
R
N
P
R
D
R
P
-----
S
V
N
S
I
L
E
K
G
F
I
A
K
R
I
E
K
F
L
S
P
Q
L
I
A
E
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
79.20
47%
-48
- C1 -
-
4B9D
1
NEK1_HUMAN
A:
[23-296]
------------------------------------------------------------------------
M
E
K
Y
V
R
L
Q
K
I
------
K
A
I
L
V
K
S
T
E
D
G
R
Q
Y
V
I
K
E
I
N
I
S
R
M
-
S
---
S
K
E
R
E
E
-
S
R
R
E
V
A
V
L
A
N
M
K
H
P
N
I
V
Q
Y
R
E
S
F
--
E
E
N
G
S
L
Y
I
V
M
D
Y
C
E
G
G
D
L
F
K
---
R
I
N
A
Q
K
---
G
V
L
F
Q
E
D
Q
I
L
D
W
F
V
Q
I
C
L
A
L
K
H
V
H
D
-
R
K
-----
I
L
H
R
D
I
K
S
Q
N
I
F
L
T
K
D
---
G
T
V
Q
L
G
D
F
G
I
A
R
V
L
N
S
T
V
E
L
A
R
A
C
-
I
G
T
P
Y
Y
L
S
P
E
I
C
E
---
N
K
-----
P
-
Y
N
N
K
S
D
I
W
A
L
G
C
V
L
Y
E
-
L
C
T
-
L
K
H
A
F
E
A
-
G
S
M
K
N
L
V
L
K
I
I
S
G
S
----------------------------
F
P
----
P
V
S
L
H
Y
S
Y
D
L
R
S
L
V
S
Q
L
F
K
R
N
P
R
D
R
P
-----
S
V
N
S
I
L
E
K
G
F
I
A
K
R
I
E
K
F
L
S
P
Q
L
I
A
E
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
Fugue
67.86
26%
19
- C1 -
-
4AW2
5
MRCKA_RAT
A:
[1-416]
S
G
E
V
R
L
R
Q
L
E
Q
F
I
L
D
GPAQTNGQCFS
V
E
T
L
L
D
I
L
I
C
L
Y
D
E
C
N
N
SPLRRE
K
N
I
L
E
Y
L
E
W
A
K
P
F
T
S
K
V
K
Q
M
RLH
R
E
D
F
E
I
L
K
V
I
G
R
G
A
F
G
E
V
A
V
V
K
L
K
N
A
D
K
V
F
A
M
K
I
L
N
K
W
E
M
-
L
---
K
R
A
E
T
A
C
F
R
E
E
R
D
V
L
V
N
G
D
S
K
W
I
T
T
L
H
Y
A
F
--
Q
D
D
N
N
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
---
L
L
S
K
F
E
---
D
R
L
-
P
E
E
M
A
R
F
Y
L
A
E
M
V
I
A
I
D
S
V
H
Q
-
L
H
-----
Y
V
H
R
D
I
K
P
D
N
I
L
M
D
M
N
---
G
H
I
R
L
A
D
F
G
S
C
L
K
L
M
E
D
G
T
V
Q
S
S
V
A
V
G
T
P
D
Y
I
S
P
E
I
L
Q
---
A
M
E
GGKG
R
-
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
-
M
L
Y
G
E
T
-
P
F
Y
A
-
E
S
L
V
E
T
Y
G
K
I
M
N
H
K
----------------------------
E
R
----
F
Q
F
P
T
Q
V
T
D
V
S
E
N
A
K
D
L
I
R
R
L
I
C
S
R
E
-----
H
-------
R
L
G
Q
N
G
I
E
D
F
K
K
H
P
F
F
---------------
S
G
I
D
W
D
N
I
R
N
C
E
A
P
Y
I
P
E
V
S
S
P
T
D
T
S
N
F
D
V
D
S
G
H
H
L
P
F
V
G
F
T
Y
T
S
S
C
V
L
S
D
R
S
C
L
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
67.13
39%
-29
- C1 -
-
2W5A
5
NEK2_HUMAN
A:
[6-271]
-------------------------------------------------------------------------
E
D
Y
E
V
L
Y
T
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
-
T
---
E
A
E
K
Q
M
-
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
---
Q
Y
L
-
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
-
R
S
------
L
H
R
D
L
K
P
A
N
V
F
L
D
G
K
---
Q
N
V
K
L
G
D
F
G
L
A
R
I
L
---
T
S
F
A
K
T
F
-
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
---
R
M
-------
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
--
M
P
P
F
T
A
-
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
----------------------------
F
R
----
R
I
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
-----
S
V
E
E
I
L
E
N
P
L
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
67.07
39%
-21
- C1 -
-
5M51
1
NEK2_HUMAN
A:
[6-271]
-------------------------------------------------------------------------
E
D
Y
E
V
L
Y
T
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
-
T
---
E
A
E
K
Q
M
-
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
---
Q
Y
L
-
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
-
R
S
DG
G
H
T
V
L
H
R
D
L
K
P
A
N
V
F
L
D
G
K
---
Q
N
V
K
L
G
D
F
-----------------
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
---
R
M
-----
S
-
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
--
M
P
P
F
T
A
-
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
----------------------------
F
R
----
R
I
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
-----
S
V
E
E
I
L
E
N
P
L
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
65.83
24%
-75
- C1 -
-
1UNL
1
CDK5_HUMAN
A:
[1-289]
------------------------------------------------------------------------
M
Q
K
Y
E
K
L
E
K
I
G
E
G
T
Y
G
T
V
F
K
A
K
N
R
E
T
H
E
I
V
A
L
K
R
V
R
L
D
D
D
-
D
---
E
G
V
P
S
S
-
A
L
R
E
I
C
L
L
K
E
L
K
H
K
N
I
V
R
L
H
D
V
L
--
H
S
D
K
K
L
T
L
V
F
E
F
C
D
Q
-
D
L
K
K
---
Y
F
D
S
C
N
---
G
D
L
-
D
P
E
I
V
K
S
F
L
F
Q
L
L
K
G
L
G
F
C
H
S
-
R
N
-----
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
R
N
---
G
E
L
K
L
A
N
F
G
L
A
R
A
F
G
I
P
V
R
C
Y
S
A
E
-
V
V
T
L
W
Y
R
P
P
D
V
L
F
---
G
A
-----
K
L
Y
S
T
S
I
D
M
W
S
A
G
C
I
F
A
E
-
L
A
N
A
G
R
-
P
L
F
P
G
N
D
V
D
D
Q
L
K
R
I
F
R
L
L
GTPTEEQWPSMTKLPD
Y
K
P
Y
P
MYPATTS
L
V
----
N
V
V
P
K
L
N
A
T
G
R
D
L
L
Q
N
L
L
K
C
N
P
V
Q
R
I
-----
S
A
E
E
A
L
Q
H
P
Y
F
S
D
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
65.08
31%
-43
- C1 -
-
3C0G
1
CSKP_HUMAN
B:
[24-295]
-------------------------------------------------------------------------
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
-
T
S
SP
G
L
S
T
E
D
-
L
K
R
E
A
S
I
C
H
M
L
K
H
P
H
I
V
E
L
L
E
T
Y
--
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
---
E
I
V
K
R
A
D
A
G
F
V
Y
-
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
-
N
N
-----
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
ENS
A
P
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
S
G
L
V
A
G
G
R
-
V
G
T
P
H
F
M
A
P
E
V
V
K
---
R
E
-----
P
-
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
-
L
L
S
G
-
C
L
P
F
Y
G
-
T
K
E
-
R
L
F
E
G
I
I
K
G
K
----------------------------
Y
K
MNP-
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
-----
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
64.32
31%
-36
- C1 -
-
3C0I
1
CSKP_HUMAN
A:
[24-295]
-------------------------------------------------------------------------
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
-
T
S
SP
G
L
S
T
E
D
-
L
K
R
E
A
S
I
C
H
M
L
K
H
P
H
I
V
E
L
L
E
T
Y
--
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
---
E
I
V
K
R
A
D
A
G
F
V
Y
-
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
-
N
N
-----
I
I
H
R
D
V
K
P
H
C
V
L
L
A
S
K
ENS
A
P
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
S
G
L
V
A
G
G
R
-
V
G
T
P
H
F
M
A
P
E
V
V
K
---
R
E
-----
P
-
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
-
L
L
S
G
-
C
L
P
F
Y
G
-
T
K
E
-
R
L
F
E
G
I
I
K
G
K
----------------------------
Y
K
M
N
P-
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
-----
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
63.65
39%
-29
- C1 -
-
2XNM
10
NEK2_HUMAN
A:
[6-271]
-------------------------------------------------------------------------
E
D
Y
E
V
L
Y
T
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
-
T
---
E
A
E
K
Q
M
-
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
---
Q
Y
L
-
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
-
R
---------
R
D
L
K
P
A
N
V
F
L
D
G
K
---
Q
N
V
K
L
G
D
F
G
L
A
R
I
L
---------
F
-
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
---
R
------
S
-
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
--
M
P
P
F
T
A
-
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
----------------------------
F
R
----
R
I
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
-----
S
V
E
E
I
L
E
N
P
L
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
61.90
39%
-27
- C1 -
-
2XKD
1
NEK2_HUMAN
A:
[6-271]
-------------------------------------------------------------------------
E
D
Y
E
V
L
Y
T
I
G
T
G
---
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
-
T
---
E
A
E
K
Q
M
-
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
---
Q
Y
L
-
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
-
R
S
D---------
L
K
P
A
N
V
F
L
D
G
K
---
Q
N
V
K
L
G
D
F
--------------
T
F
-
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
---
R
M
-----
S
-
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
--
M
P
P
F
T
A
-
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
----------------------------
F
R
----
R
I
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
-----
S
V
E
E
I
L
E
N
P
L
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
61.47
39%
-14
- C1 -
-
2XNO
13
NEK2_HUMAN
A:
[6-271]
-------------------------------------------------------------------------
E
D
Y
E
V
L
Y
T
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
-
T
---
E
A
E
K
Q
M
-
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
ID
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
---
Q
Y
L
-
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
-
R
S
--------
R
D
L
K
P
A
N
V
F
L
D
G
K
---
Q
N
V
K
L
G
D
F
---------------
F
-
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
---
R
---------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
--
M
P
P
F
T
A
-
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
----------------------------
F
R
----
R
I
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
-----
S
V
E
E
I
L
E
N
P
L
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
61.21
39%
-20
- C1 -
-
2XNN
6
NEK2_HUMAN
A:
[6-271]
-------------------------------------------------------------------------
E
D
Y
E
V
L
Y
T
I
G
T
--
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
-
T
---
E
A
E
K
Q
M
-
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
ID
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
---
Q
Y
L
-
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
-
R
S
--------
R
D
L
K
P
A
N
V
F
L
D
G
K
---
Q
N
V
K
L
G
D
F
G
--------------
F
-
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
---
R
--------
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
--
M
P
P
F
T
A
-
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
----------------------------
F
R
----
R
I
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
-----
S
V
E
E
I
L
E
N
P
L
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
61.17
29%
-20
- C1 -
-
4GV1
5
AKT1_HUMAN
A:
[8-281]
-------------------------------------------------------------------------
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
A
T
G
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
---
K
D
E
V
A
H
-
T
L
T
E
N
R
V
L
Q
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
--
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
---
H
L
S
R
E
----
R
V
F
-
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
-----
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
---
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
A
T
M
K
T
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
---
D
N
-----
D
-
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
-
M
M
C
G
-
R
L
P
F
Y
N
-
Q
D
H
E
K
L
F
E
L
I
L
M
E
E
----------------------------
I
-----
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
GGGS
E
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
60.93
39%
-15
- C1 -
-
2XKF
1
NEK2_HUMAN
A:
[6-271]
-------------------------------------------------------------------------
E
D
Y
E
V
L
Y
T
I
G
T
G
---
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
-
T
---
E
A
E
K
Q
M
-
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
---
Q
Y
L
-
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
-
R
S
--------
R
D
L
K
P
A
N
V
F
L
D
G
K
---
Q
N
V
K
L
G
D
F
---------------
F
-
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
---
R
------
S
-
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
--
M
P
P
F
T
A
-
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
----------------------------
F
R
----
R
I
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
-----
S
V
E
E
I
L
E
N
P
L
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
60.89
27%
-82
- C1 -
-
4XBR
1
INKA1_HUMAN (first)
A:
[95-351]
--------------------------------------------------------------------------
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
------
Q
Q
R
R
E
L
-
L
F
N
E
V
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
--
L
V
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
---
I
V
T
H
T
-----
R
M
-
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
-
Q
G
-----
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
---
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
P
R
R
K
S
L
-
V
G
T
P
Y
W
M
A
P
E
L
I
S
---
R
L
-----
P
-
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
-
M
V
D
G
-
E
P
P
Y
F
N
-
E
P
P
L
K
A
M
K
M
I
R
D
N
L
----------------------------
P
P
RL--
K
N
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
-----
T
A
A
E
L
L
K
H
P
F
L
A
K
A
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
60.77
28%
-69
- C1 -
-
5J5T
1
M4K3_HUMAN
A:
[4-270]
-------------------------------------------------------------------------
E
D
F
E
L
I
Q
R
I
G
S
G
T
Y
G
D
V
Y
K
A
R
N
V
N
T
G
E
L
A
A
I
K
V
I
K
L
E
P
------
G
E
D
F
A
V
-
V
Q
Q
E
I
I
M
M
K
D
C
K
H
P
N
I
V
A
Y
F
G
S
Y
--
L
R
R
D
K
L
W
I
C
M
E
F
C
G
G
G
S
L
Q
D
---
I
Y
H
V
T
----
G
P
L
-
S
E
L
Q
I
A
Y
V
S
R
E
T
L
Q
G
L
Y
Y
L
H
S
-
K
G
-----
K
M
H
R
D
I
K
G
A
N
I
L
L
T
D
N
---
G
H
V
K
L
A
D
F
G
V
S
A
Q
I
T
A
T
I
A
---
A
F
-
I
G
T
P
Y
W
M
A
P
E
V
A
A
V
ER
K
G
-----
G
-
Y
N
Q
L
C
D
L
W
A
V
G
I
T
A
I
E
-
L
A
E
L
-
Q
P
P
M
F
D
-
L
H
P
M
R
A
L
F
L
M
T
K
S
N
----------------------------
F
Q
P
P
KL
K
D
K
M
K
W
S
N
S
F
H
H
F
V
K
M
A
L
T
K
N
P
K
K
R
P
-----
T
A
E
K
L
L
Q
H
P
F
V
T
Q
H
L
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
60.70
39%
-19
- C1 -
-
2XNP
6
NEK2_HUMAN
A:
[6-271]
-------------------------------------------------------------------------
E
D
Y
E
V
L
Y
T
I
G
T
G
-
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
-
T
---
E
A
E
K
Q
M
-
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
ID
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
---
Q
Y
L
-
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
-
R
S
-------
H
R
D
L
K
P
A
N
V
F
L
D
G
K
---
Q
N
V
K
L
G
D
F
G
L
-------------
F
-
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
---
R
---------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
--
M
P
P
F
T
A
-
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
----------------------------
F
R
----
R
I
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
-----
S
V
E
E
I
L
E
N
P
L
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
60.66
39%
-20
- C1 -
-
2XK4
1
NEK2_HUMAN
A:
[6-271]
-------------------------------------------------------------------------
E
D
Y
E
V
L
Y
T
I
G
T
--
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
-
T
---
E
A
E
K
Q
M
-
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
ID
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
---
Q
Y
L
-
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
-
R
S
--------
R
D
L
K
P
A
N
V
F
L
D
G
K
---
Q
N
V
K
L
G
D
F
G
L
-------------
F
-
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
---
R
M
--------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
--
M
P
P
F
T
A
-
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
----------------------------
F
R
----
R
I
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
-----
S
V
E
E
I
L
E
N
P
L
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
59.37
39%
-17
- C1 -
-
2XKE
1
NEK2_HUMAN
A:
[6-271]
-------------------------------------------------------------------------
E
D
Y
E
V
L
Y
T
I
G
T
G
---
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
-
T
---
E
A
E
K
Q
M
-
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
---
Q
Y
L
-
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
-
R
S
D---------
L
K
P
A
N
V
F
L
D
G
K
---
Q
N
V
K
L
G
D
F
-------------------
T
P
Y
Y
M
S
P
E
Q
M
N
-------------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
--
M
P
P
F
T
A
-
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
----------------------------
F
R
----
R
I
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
-----
S
V
E
E
I
L
E
N
P
L
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
57.77
39%
-16
- C1 -
-
2XK8
1
NEK2_HUMAN
A:
[6-271]
-------------------------------------------------------------------------
E
D
Y
E
V
L
Y
T
I
G
T
----
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
-
T
---
E
A
E
K
Q
M
-
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
ID
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
---
Q
Y
L
-
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
-
R
S
--------
R
D
L
K
P
A
N
V
F
L
D
G
K
---
Q
N
V
K
L
G
D
F
---------------
F
-
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
-------------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
--
M
P
P
F
T
A
-
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
----------------------------
F
R
----
R
I
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
-----
S
V
E
E
I
L
E
N
P
L
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
57.12
39%
-13
- C1 -
-
2XK7
1
NEK2_HUMAN
A:
[6-271]
-------------------------------------------------------------------------
E
D
Y
E
V
L
Y
T
I
G
T
G
---
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
-
T
---
E
A
E
K
Q
M
-
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
---
Q
Y
L
-
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
-
R
S
--------
R
D
L
K
P
A
N
V
F
L
D
G
K
---
Q
N
V
K
L
G
D
F
-----------------
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
-------------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
--
M
P
P
F
T
A
-
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
----------------------------
F
R
----
R
I
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
-----
S
V
E
E
I
L
E
N
P
L
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
56.89
39%
-10
- C1 -
-
2XKC
1
NEK2_HUMAN
A:
[6-271]
-------------------------------------------------------------------------
E
D
Y
E
V
L
Y
T
I
G
T
--
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
-
T
---
E
A
E
K
Q
M
-
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
---
Q
Y
L
-
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
-
R
S
----------
L
K
P
A
N
V
F
L
D
G
K
---
Q
N
V
K
L
G
D
-------------------
G
T
P
Y
Y
M
S
P
E
Q
M
N
---
R
---------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
--
M
P
P
F
T
A
-
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
----------------------------
F
R
----
R
I
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
-----
S
V
E
E
I
L
E
N
P
L
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
56.87
39%
-4
- C1 -
-
2XK3
1
NEK2_HUMAN
A:
[6-271]
-------------------------------------------------------------------------
E
D
Y
E
V
L
Y
T
I
G
T
----
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
-
T
---
E
A
E
K
Q
M
-
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
ID
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
---
Q
Y
L
-
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
-
R
S
--------
R
D
L
K
P
A
N
V
F
L
D
G
K
---
Q
N
V
K
L
G
D
F
G
----------------
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
---
R
---------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
--
M
P
P
F
T
A
-
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
----------------------------
F
R
----
R
I
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
-----
S
V
E
E
I
L
E
N
P
L
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
55.18
39%
-5
- C1 -
-
2WQO
1
NEK2_HUMAN
A:
[6-271]
-------------------------------------------------------------------------
E
D
Y
E
V
L
Y
T
I
G
T
G
---
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
-
T
---
E
A
E
K
Q
M
-
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
ID
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
---
Q
Y
L
-
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
-
R
-----------
L
K
P
A
N
V
F
L
D
G
K
---
Q
N
V
K
L
G
D
-------------------
G
T
P
Y
Y
M
S
P
E
Q
M
N
---
R
---------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
--
M
P
P
F
T
A
-
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
----------------------------
F
R
----
R
I
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
-----
S
V
E
E
I
L
E
N
P
L
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
54.53
39%
-7
- C1 -
-
2XK6
1
NEK2_HUMAN
A:
[6-271]
-------------------------------------------------------------------------
E
D
Y
E
V
L
Y
T
I
G
-----
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
-
T
---
E
A
E
K
Q
M
-
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
ID
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R
---
Q
Y
L
-
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
-
R
S
--------
R
D
L
K
P
A
N
V
F
L
D
G
K
---
Q
N
V
K
L
G
D
------------------
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
---
R
---------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
--
M
P
P
F
T
A
-
F
S
Q
K
E
L
A
G
K
I
R
E
G
K
----------------------------
F
R
----
R
I
P
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
-----
S
V
E
E
I
L
E
N
P
L
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------