@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : MPK3: (2018-07-14 )
MHKSNQELSVPKIVGDFKVYNVSGSPFEVPSKYTLLKILGMGAYGIACSCLDGDTGEKVSIKKCRDVFRDVEDGKRVLREIDMMRFFHHENLLNVVNILPPLKREYHSFEDVYVVTPLMDVDMNVVLRSRQVLEESHMQYFVYQILRGLKYLHSANVAHRDLKPANLVTNISCELKIIDFGLSRSVDVPYSELTDYVITRWYRPPELLLENTNYSTAVDIWSVGCIFAEMYNRKPVFPGRNTMDQLRMIAQHIGKPPASIVEHREALEKLNELPDGSLNIPKLVPGLAGNTEGIDFLSKMWTLDPSKRPTAADMLAHPYLAHLHDEEDEPTCPCPFLWAHESTPMGVSELRRAFWADIVDYNPSLEQATPPVTTAGGSSSKNGSGHHH
Atome Classification :
(22 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190---........200.......210.......220.......230.......240.......250.......260.------.---.---....270....-...280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MHKSNQELSV
P
K
I
V
GD
F
K
V
Y
NVSGSPFEVPS
K
Y
T
L
L
K
I
LGMGAY
G
I
A
C
S
CLDGDTGE
K
V
S
I
K
K
C
R
D
V
F
R
D
V
E
D
G
K
R
V
L
R
E
I
D
M
M
R
F
F
H
H
E
N
L
L
N
V
V
N
ILP
P
L
K
R
E
YHSFE
D
V
Y
V
VTPLMDV
D
M
N
V
V
L
R
S
R
Q
V
L
E
E
S
H
M
Q
Y
F
V
Y
Q
I
L
R
G
L
K
Y
L
H
SANVAHRDLKPA
N
L
V
TN
I
S
C
E
L
K
I
I
DFGLSRSVDV
P
Y
S
----
E
L
T
D
Y
V
I
T
RWYR
P
P
E
L
L
L
ENTNY
S
T
A
V
D
I
W
S
V
G
C
I
F
A
E
M
YNRKPVFPGRN
T
M
D
Q
L
R
M
I
A
Q
H
IGKP
P
A
S
I
V
E
H
------
R
---
E
---
A
L
E
K
L
N
ELPDG-SLNI
P
K
LVPGLAGNT
E
G
I
D
F
L
S
K
M
WTLDPSKRP
T
A
A
D
M
L
A
H
P
Y
L
A
H
LHDEEDEPTCPCP
F
L
WAHESTPM
G
V
S
E
L
R
R
A
F
W
A
D
I
VDYNPSLEQATPPVTTAGGSSSKNGSGHHH
21
HHSearch
99.65
99%
-115
- C1 -
-
4O2Z
1
?
A:
[17-377]
--
Q
G
N
Q
E
L
S
V
P
K
I
V
G
D
F
K
V
Y
N
V
S
G
S
P
F
E
V
P
S
K
Y
T
L
L
K
I
L
G
M
G
A
Y
G
I
A
C
S
C
L
D
G
D
T
G
E
K
V
S
I
K
K
C
R
D
V
F
R
D
V
E
D
G
K
R
V
L
R
E
I
D
M
M
R
F
F
H
H
E
N
L
L
N
V
V
N
I
L
P
P
L
K
R
E
Y
H
S
F
E
D
V
Y
V
V
T
P
L
M
D
V
D
M
N
V
V
L
R
S
R
Q
V
L
E
E
S
H
M
Q
Y
F
V
Y
Q
I
L
R
G
L
K
Y
L
H
S
A
N
V
A
H
R
D
L
K
P
A
N
L
V
T
N
I
S
C
E
L
K
I
I
D
F
G
L
S
R
S
--
V
P
Y
S
----
E
L
T
D
Y
V
I
T
R
W
Y
R
P
P
E
L
L
L
E
N
T
N
Y
S
T
A
V
D
I
W
S
V
G
C
I
F
A
E
M
Y
N
R
K
P
V
F
P
G
R
N
T
M
D
Q
L
R
M
I
A
Q
H
I
G
K
P
P
A
S
I
V
E
H
------
R
---
E
---
A
L
E
K
L
N
E
L
P
D
G
-
S
L
N
I
P
K
L
V
P
G
L
A
G
N
T
E
G
I
D
F
L
S
K
M
W
T
L
D
P
S
K
R
P
T
A
A
D
M
L
A
H
P
Y
L
A
H
L
H
D
E
E
D
E
P
T
C
P
C
P
F
L
W
A
H
E
S
T
P
M
G
V
S
E
L
R
R
A
F
W
A
D
I
V
D
Y
N
P
-------------------------
1
PsiBlast_PDB
99.65
99%
-115
- C1 -
-
4O2Z
1
?
A:
[17-377]
--
Q
G
N
Q
E
L
S
V
P
K
I
V
G
D
F
K
V
Y
N
V
S
G
S
P
F
E
V
P
S
K
Y
T
L
L
K
I
L
G
M
G
A
Y
G
I
A
C
S
C
L
D
G
D
T
G
E
K
V
S
I
K
K
C
R
D
V
F
R
D
V
E
D
G
K
R
V
L
R
E
I
D
M
M
R
F
F
H
H
E
N
L
L
N
V
V
N
I
L
P
P
L
K
R
E
Y
H
S
F
E
D
V
Y
V
V
T
P
L
M
D
V
D
M
N
V
V
L
R
S
R
Q
V
L
E
E
S
H
M
Q
Y
F
V
Y
Q
I
L
R
G
L
K
Y
L
H
S
A
N
V
A
H
R
D
L
K
P
A
N
L
V
T
N
I
S
C
E
L
K
I
I
D
F
G
L
S
R
S
--
V
P
Y
S
----
E
L
T
D
Y
V
I
T
R
W
Y
R
P
P
E
L
L
L
E
N
T
N
Y
S
T
A
V
D
I
W
S
V
G
C
I
F
A
E
M
Y
N
R
K
P
V
F
P
G
R
N
T
M
D
Q
L
R
M
I
A
Q
H
I
G
K
P
P
A
S
I
V
E
H
------
R
---
E
---
A
L
E
K
L
N
E
L
P
D
G
-
S
L
N
I
P
K
L
V
P
G
L
A
G
N
T
E
G
I
D
F
L
S
K
M
W
T
L
D
P
S
K
R
P
T
A
A
D
M
L
A
H
P
Y
L
A
H
L
H
D
E
E
D
E
P
T
C
P
C
P
F
L
W
A
H
E
S
T
P
M
G
V
S
E
L
R
R
A
F
W
A
D
I
V
D
Y
N
P
-------------------------
12
PsiBlast_PDB
72.16
39%
-88
- C1 -
-
3FLW
1
MK14_HUMAN
A:
[20-362]
----------------
F
Y
R
Q
E
L
N
-
T
I
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
D
T
K
T
G
L
R
V
A
V
K
K
L
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
-
A
R
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
K
C
-
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
---
H
T
D
---
D
----
E
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
L
L
K
K
ISS
E
S
A
R
---
N
---
Y
I
Q
S
L
T
Q
M
P
---
K
M
N
F
A
N
V
F
I
G
--
A
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
V
A
D
-
P
Y
D
Q
S
F
E
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
-------------------------
32
HHSearch
71.71
40%
-99
- C1 -
-
2YIX
1
MK14_HUMAN
A:
[10-347]
---------------------
L
N
K
T
I
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
D
T
K
T
G
L
R
V
A
V
K
K
L
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
A
R
S
-
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
K
C
-
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
R
H
T
D
D
E
-------
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
L
L
K
K
------
I
SS
E
S
---
A
R
N
Y
I
Q
S
L
T
Q
M
P
K
M
N
F
A
N
V
F
--
I
G
A
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
V
A
-
D
P
Y
D
Q
S
F
E
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
-------------------------
18
PsiBlast_PDB
71.53
39%
-89
- C1 -
-
3FMN
1
MK14_HUMAN
A:
[20-362]
----------------
F
Y
R
Q
E
L
N
K
T
I
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
----
G
S
V
C
A
A
F
D
T
K
T
G
L
R
V
A
V
K
K
L
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
-
A
R
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
K
C
-
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
----
T
D
---
D
----
E
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
L
L
K
K
ISS
E
S
A
R
---
N
---
Y
I
Q
S
L
T
Q
M
P
---
K
M
N
F
A
N
V
F
I
G
--
A
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
V
A
D
-
P
Y
D
Q
S
F
E
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
-------------------------
16
PsiBlast_PDB
71.41
39%
-90
- C1 -
-
3FMJ
1
MK14_HUMAN
A:
[20-362]
----------------
F
Y
R
Q
E
L
N
K
T
I
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
---
Y
G
S
V
C
A
A
F
D
T
K
T
G
L
R
V
A
V
K
K
L
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
-
A
R
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
K
C
-
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
--
R
H
T
D
---
D
----
E
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
L
L
K
K
ISS
E
S
A
R
---
N
---
Y
I
Q
S
L
T
Q
M
P
---
K
M
N
F
A
N
V
F
I
G
--
A
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
V
A
D
-
P
Y
D
Q
S
F
E
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
-------------------------
15
PsiBlast_PDB
71.38
39%
-85
- C1 -
-
3FMH
1
MK14_HUMAN
A:
[20-362]
----------------
F
Y
R
Q
E
L
N
K
T
I
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
D
T
K
T
G
L
R
V
A
V
K
K
L
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
-
A
R
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
K
C
-
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
--
H
T
D
---
D
----
E
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
L
L
K
K
ISS
E
S
A
R
---
N
---
Y
I
Q
S
L
T
Q
M
P
---
K
M
N
F
A
N
V
F
I
G
--
A
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
V
A
D
-
P
Y
D
Q
S
F
E
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
-------------------------
19
PsiBlast_PDB
71.18
39%
-90
- C1 -
-
3FSF
1
MK14_HUMAN
A:
[20-362]
----------------
F
Y
R
Q
E
L
N
K
T
I
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
-----
V
C
A
A
F
D
T
K
T
G
L
R
V
A
V
K
K
L
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
-
A
R
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
K
C
-
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
---
H
T
D
---
D
----
E
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
L
L
K
K
ISS
E
S
A
R
---
N
---
Y
I
Q
S
L
T
Q
M
P
---
K
M
N
F
A
N
V
F
I
G
--
A
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
V
A
D
-
P
Y
D
Q
S
F
E
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
-------------------------
27
HHSearch
70.92
40%
-93
- C1 -
-
3COI
-
MK13_HUMAN
A:
[11-351]
------------------
K
Q
D
V
N
K
T
A
W
E
L
P
K
T
Y
V
S
P
T
H
V
G
S
G
A
Y
G
S
V
C
S
A
I
D
K
R
S
G
E
K
V
A
I
K
K
L
S
R
P
F
Q
S
E
I
F
A
K
R
A
Y
R
E
L
L
L
L
K
H
M
Q
H
E
N
V
I
G
L
L
D
V
F
T
P
A
S
S
-
L
R
N
F
Y
D
F
Y
L
V
M
P
F
M
Q
T
D
L
Q
K
I
M
G
--
L
K
F
S
E
E
K
I
Q
Y
L
V
Y
Q
M
L
K
G
L
K
Y
I
H
S
A
G
V
V
H
R
D
L
K
P
G
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
R
H
---------------
V
V
T
R
W
Y
R
A
P
E
V
I
L
S
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
M
L
T
G
K
T
L
F
K
G
K
D
Y
L
D
Q
L
T
Q
I
L
K
V
T
G
V
P
G
T
E
F
V
Q
K
------
L
ND
K
A
---
A
K
S
Y
I
Q
S
L
P
Q
T
P
R
K
D
F
T
Q
L
F
P
--
R
A
S
P
Q
A
A
D
L
L
E
K
M
L
E
L
D
V
D
K
R
L
T
A
A
Q
A
L
T
H
P
F
F
E
P
F
R
D
P
E
E
E
T
E
A
Q
Q
P
F
D
D
S
L
E
H
E
K
L
T
V
D
E
W
K
Q
H
I
Y
K
E
I
V
N
F
S
P
-------------------------
28
HHSearch
70.81
40%
-101
- C1 -
-
2FST
3
MK14_HUMAN
X:
[15-357]
----------------
F
Y
R
Q
E
L
N
K
T
I
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
----
G
S
V
C
A
A
F
D
T
K
T
G
L
R
V
A
V
K
K
L
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
A
R
S
-
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
------
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
----------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
L
L
K
K
------
I
SSE
S
---
A
R
N
Y
I
Q
S
L
T
Q
M
P
K
M
N
F
A
N
V
F
I
--
G
A
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
V
A
D
-
P
Y
D
Q
S
L
E
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
-------------------------
8
PsiBlast_PDB
70.79
39%
-85
- C1 -
-
3FKN
1
MK14_HUMAN
A:
[20-362]
----------------
F
Y
R
Q
E
L
N
K
T
I
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
D
T
K
T
G
L
R
V
A
V
K
K
L
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
-
A
R
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
K
C
-
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
---
H
T
D
---
D
----
E
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
L
L
K
K
ISS
E
S
A
R
---
N
---
Y
I
Q
S
L
T
Q
M
P
---
K
M
N
F
A
N
V
F
I
G
--
A
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
V
A
D
-
P
Y
D
Q
S
F
E
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
-------------------------
7
PsiBlast_PDB
70.79
39%
-85
- C1 -
-
3FKL
1
MK14_HUMAN
A:
[20-362]
----------------
F
Y
R
Q
E
L
N
K
T
I
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
D
T
K
T
G
L
R
V
A
V
K
K
L
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
-
A
R
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
K
C
-
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
------------
E
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
L
L
K
K
ISS
E
S
A
R
---
N
---
Y
I
Q
S
L
T
Q
M
P
---
K
M
N
F
A
N
V
F
I
G
--
A
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
V
A
D
-
P
Y
D
Q
S
F
E
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
-------------------------
20
PsiBlast_PDB
70.64
39%
-90
- C1 -
-
3FSK
1
MK14_HUMAN
A:
[20-362]
----------------
F
Y
R
Q
E
L
N
K
T
I
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
D
T
K
T
G
L
R
V
A
V
K
K
L
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
-
A
R
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
K
C
-
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
------
D
---
D
----
E
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
L
L
K
K
ISS
E
S
A
R
---
N
---
Y
I
Q
S
L
T
Q
M
P
---
K
M
N
F
A
N
V
F
I
G
--
A
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
V
A
D
-
P
Y
D
Q
S
F
E
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
-------------------------
9
PsiBlast_PDB
70.35
39%
-91
- C1 -
-
3FL4
1
MK14_HUMAN
A:
[20-362]
----------------
F
Y
R
Q
E
L
N
K
T
I
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
D
T
K
T
G
L
R
V
A
V
K
K
L
--
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
-
A
R
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-----
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
----
T
D
---
D
----
E
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
L
L
K
K
ISS
E
S
A
R
---
N
---
Y
I
Q
S
L
T
Q
M
P
---
K
M
N
F
A
N
V
F
I
G
--
A
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
V
A
D
-
P
Y
D
Q
S
F
E
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
-------------------------
29
HHSearch
70.34
40%
-96
- C1 -
-
4YNO
-
MK13_HUMAN
A:
[13-351]
--------------------
D
V
N
K
T
A
W
E
L
P
K
T
Y
V
S
P
T
H
V
G
S
G
A
Y
G
S
V
C
S
A
I
D
K
R
S
G
E
K
V
A
I
K
K
L
S
R
P
F
Q
S
E
I
F
A
K
R
A
Y
R
E
L
L
L
L
K
H
M
Q
H
E
N
V
I
G
L
L
D
V
F
T
P
A
S
S
-
L
R
N
F
Y
D
F
Y
L
V
M
P
F
M
Q
T
D
L
Q
K
I
M
G
--
M
E
F
S
E
E
K
I
Q
Y
L
V
Y
Q
M
L
K
G
L
K
Y
I
H
S
A
G
V
V
H
R
D
L
K
P
G
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
---------------
G
Y
V
V
T
R
W
Y
R
A
P
E
V
I
L
S
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
M
L
T
G
K
T
L
F
K
G
K
D
Y
L
D
Q
L
T
Q
I
L
K
V
T
G
V
P
G
T
E
F
V
Q
K
------
L
---
N
D
K
A
A
K
S
Y
I
Q
S
L
P
Q
T
P
R
K
D
F
T
Q
L
F
P
--
R
A
S
P
Q
A
A
D
L
L
E
K
M
L
E
L
D
V
D
K
R
L
T
A
A
Q
A
L
T
H
P
F
F
E
P
F
R
D
P
E
E
E
T
E
A
Q
Q
P
F
D
D
S
L
E
H
E
K
L
T
V
D
E
W
K
Q
H
I
Y
K
E
I
V
N
F
S
P
-------------------------
13
PsiBlast_PDB
70.13
39%
-86
- C1 -
-
3FLY
1
MK14_HUMAN
A:
[20-362]
----------------
F
Y
R
Q
E
L
N
K
T
I
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
D
T
K
T
G
L
R
V
A
V
K
K
L
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
-
A
R
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
K
C
-
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
--
H
T
D
---
D
----
E
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
L
L
K
K
ISS
E
S
A
R
---
N
---
Y
I
Q
S
L
T
Q
M
P
---
K
M
N
F
A
N
V
F
I
G
--
A
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
V
A
D
-
P
Y
D
Q
S
F
E
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
-------------------------
6
PsiBlast_PDB
69.80
39%
-85
- C1 -
-
2GFS
1
MK14_HUMAN
A:
[20-362]
----------------
F
Y
R
Q
E
L
N
K
T
I
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
D
T
K
T
G
L
R
V
A
V
K
K
L
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
-
A
R
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
K
C
-
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
----
H
T
D
---
D
----
E
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
L
L
K
K
ISS
E
S
A
R
---
N
---
Y
I
Q
S
L
T
Q
M
P
---
K
M
N
F
A
N
V
F
I
G
--
A
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
V
A
D
-
P
Y
D
Q
S
F
E
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
-------------------------
11
PsiBlast_PDB
69.32
39%
-90
- C1 -
-
3FLS
1
MK14_HUMAN
A:
[20-362]
----------------
F
Y
R
Q
E
L
N
K
T
I
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
----
S
V
C
A
A
F
D
T
K
T
G
L
R
V
A
V
K
K
L
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
-
A
R
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
K
C
-
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
--
H
T
D
---
D
----
E
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
L
L
K
K
ISS
E
S
A
R
---
N
---
Y
I
Q
S
L
T
Q
M
P
---
K
M
N
F
A
N
V
F
I
G
--
A
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
V
A
D
-
P
Y
D
Q
S
F
E
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
-------------------------
5
PsiBlast_PDB
69.30
39%
-83
- C1 -
-
1OZ1
1
MK14_HUMAN
A:
[20-362]
----------------
F
Y
R
Q
E
L
N
K
T
I
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
D
T
K
T
G
L
R
V
A
V
K
K
L
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
-
A
R
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-----
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
R
H
T
D
---
D
----
E
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
L
L
K
K
ISS
E
S
A
R
---
N
---
Y
I
Q
S
L
T
Q
M
P
---
K
M
N
F
A
N
V
F
I
G
--
A
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
V
A
D
-
P
Y
D
Q
S
F
E
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
-------------------------
14
PsiBlast_PDB
68.98
39%
-86
- C1 -
-
3FLZ
1
MK14_HUMAN
A:
[20-362]
----------------
F
Y
R
Q
E
L
N
K
T
I
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
D
T
K
T
G
L
R
V
A
V
K
K
L
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
P
-
A
R
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
K
C
-
Q
K
L
T
D
D
H
V
Q
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
--
H
T
D
---
D
----
E
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
Q
L
K
L
I
L
R
L
V
G
T
P
G
A
E
L
L
K
K
ISS
E
S
A
R
---
N
---
Y
I
Q
S
L
T
Q
M
P
---
K
M
N
F
A
N
V
F
I
G
--
A
N
P
L
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
V
A
D
-
P
Y
D
Q
S
F
E
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
P
-------------------------
22
HHSearch
64.54
40%
-69
- C1 -
-
5BYZ
7
MK07_HUMAN
A:
[3-342]
---------------------------
D
V
G
D
E
Y
E
I
I
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
R
R
L
T
G
Q
Q
V
A
I
K
K
I
P
N
A
F
D
V
V
T
N
A
K
R
T
L
R
E
L
K
I
L
K
H
F
K
H
D
N
I
I
A
I
K
D
I
L
R
P
T
V
P
-
Y
G
E
F
K
S
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
H
S
S
Q
P
L
T
L
E
H
V
R
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
E
N
C
E
L
K
I
G
D
F
G
M
A
R
G
L
C
T
S
P
A
EHQY
F
M
T
E
Y
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
H
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
R
R
Q
L
F
P
G
K
N
Y
V
H
Q
L
Q
L
I
M
M
V
L
G
T
P
S
P
A
V
I
Q
A
------
V
GA
E
R
---
V
R
A
Y
I
Q
S
L
P
P
R
Q
P
V
P
W
E
T
V
Y
P
--
G
A
D
R
Q
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
Y
H
D
P
D
D
E
P
D
C
A
P
P
F
D
F
A
F
D
R
E
A
L
T
R
E
R
I
K
E
A
I
V
A
E
I
E
D
F
H
--------------------------
30
HHSearch
58.97
41%
-51
* C1 *
-
4ZZN
1
MK01_HUMAN
A:
[9-345]
--------------------------
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
D
N
L
N
K
V
R
V
A
I
K
K
I
S
P
F
E
-
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
--
I
E
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
K
T
-
Q
H
L
S
N
D
H
I
C
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
V
A
D
P
D
H
D
H
T
G
-
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
Q
L
N
H
I
L
G
I
L
G
S
P
S
Q
E
D
L
N
C
------
I
I
N
L
K
---
A
R
N
Y
L
L
S
L
P
H
K
N
K
V
P
W
N
R
L
F
P
--
N
A
D
S
K
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
E
A
P
F
------
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
Q
--------------------------