@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : TOR1: (2018-07-14 )
MESKGGVGSSNGSGGTSSNRHPLIGQLRPIFQELESATPQTLPSIILKLEYVIEEEKDALFHRNSIKSYTANARTFPNWLNAQLRHLFEQPQTHMAGVQVLRALLPVEYVELNEMTKLFSELLVRCVLETADYNTAVEGGEVWGLLLNNGSSVVEGIIINCLQFSLALLMRGGHDEIFLREDVSHRGVDSEATVRSAMSPLVDSSRQGENAVLTDDDRFPKATKLSGCIFIQQLVRRVPSTIAPHVHNILECLRRAILDSNKLVRVSGGDALFYTLTISYRSTDPKFYSRWQNTFLEDAERSVMYGSDVVLHGCLLAFNAVLSATASREAEGRAVGFSNQGRKHILQFWTFINDNLVSTSHNSDVRAEVLNALPLLAQYDSTTFKEISVKHVRALAAAVFVGTEGKDERAMVFQVLARLFTVLPSLVVPFLDFMMKYIEASLTPQPLRDRCPEAVTCFATLSSVEPNAVRPFLRPLLGPLFAGSVTEHFARDVAKICTAFPELRSTCLSKVLEATKEQLLRMRNRPRHTSASSETDHSAIVRSLNSLGSLDFTGYSTLQFLCDAVIRYVSDPHEEVRRSAIDLCFKLALSGCSQSPCERTAVGVVIHRGREHLGLVNTVIRKLVSAAVADTESDIRLHTLEHLSTEFDYSLALQDICTALFPALHDHHQNRIAAVRLLGRLSSRNPSCILPMLRCVMVQCIMDIQLFHEPKRQEQAAVVLSAVVESAPAMARPYISSLLQDCVTRLQEENKPVPVITALLSLVGRLARYAEDDDVAVVAAIRPCVIRHILDSSSIQKKIEAIRALGDIIRTTKDVDVYETNPELLRVLLSALHGGFKETWPVRLDVLKLMGIIGAVDPVRAKEITRHLRDGGLSSSGAAAPAALQLSSSRGEEAIAQNVVKNVLGVLQLPCLSDDQCLCAVQVIANTLSLKEAASGCLTPMYRDILHTVVQQITLQAKIRENLFGVMTHIVYLYGQHIRPYLDELISTCVGFLPAAERGVLVEILCLLREMRRSLREEFSPSLSLVLPPLIQTVQADAAHSSEPVFAFLIEMGHLLDDHLHNVVPCVCEVASNPAYPVACRAAAADAIRHFARRLPRLVFHASRCVHCLCRVLKEMESHPLLFEQQPGASADAAQRRPAAELAAGGDTTASDVRSFVAVTLDAVRVVGRNLGSDFEKYTPLVFPLLDGYGQDGQDVKAFTLSTLRTSGRVVAPENAQAQEEETAARYRVNTQQLAQRRKAALEDNFAQLRSILLARDRETEEEWNLWLKQLAVELLRSSPSNAHGFAFALAQLHEPFARQMLHSAFAVCYAEMEPRTKEAVRALLGNVLRSDRVPSEVLQELLNLSEYMERLEMRFNPKEGSHSTYAGLLFDLKTLMGSSERCNFYAKALHYVEIQFYEATYEYERNVMRGQVRPLPPEEWSKLVQWCEKSIYLCNLLGLRESAEGMLKYIQRNFSFLTGKPPSELPLMMDAQLLEKLQWWSQSLRAYEKGLQAEPNKFSNMVGLMRSLDNLGDYGRLLESWKLFYPRITRKEASELAPYGAHAAWLLRCWDDMEKITAYMTDEGYVGTTAVFYRAVLATHKLQFHDAVPVIQNCRKRLDSTLSALVAESYDRAYGLFVGIQQLSELEEFAFVADNPQGLNHWQELWEKRLAAMAYEGWPGTLANHTLVIPLAQELEMWLRFVSLSRVHGRDRTSRDILFELLGKQTIAAALEQPRLPQPPIALAACQHFYDINERERAVELLETYLKKMDQAAPSLLDIGGGQASLAMCHAKLASWLFTVAKKKRQNVDAHYREYIRHHLEKATSLDSTNGTIWHTWARFNHDLVTHRSRGAASEVRRDEHVKHIVAAMDGYVRSVSCSQELEDMLGFLSLWFIHAALPQVQENAALQAEILQVSPTVWLKVLPQIIARLHSRDAVVSESVFQLLTIVAKAHPQALLYNLNVTLNSSVRGTESNTTEQMERKQAAQRLLGRIKEMHNHGRTMVKDAALVCQELVRCAVLWTELWFDELERAWFQWGRDKNAHNVFLVLQPLLEQLSHPNTLAESHFVAEFGELLGGACEYVEKAASTGNNVYMEDAWNRFKTAVKRMDEQINGMNSLALQLVSPRLMQSGKDLSLVVPGQYNEGGVYPRIASFQSTLRVMNSKQHPRRLYMTGTDGVLYKFLLKGHEDLRLDERVMQLLAFVNTLLEKHSAIQRRDCMIQVFSVTPLSENAGLVGWVDNCDTLHQLIKDYRVHSKYLSIEMNLMLSFNVDLDRLQVIQHVEPFEFALEQTEGADLANSLWMRAPSAESWLDRRTTYVCSLATMSMVGHILGLGDRHPSNLMIHSFSGRVVHIDFGDCFDVAQNRSAFPEKVPFRLTRMLVKAMEMGGIDGLFRHGCITVMGVLREEGSSILALLEAFVHDPLVSWWRDESEDGATASAAVASAAPSSSIPSAGAAAALGHYSQRAAYAAIGESFHKSRTAFASRTPASRSLAPRGRSFRAPQTSIASSPSAPPPLVSDRSSDILSNMSVNHTSEAKKVVNRIREKLEGREFAAWQLQASASAHAADDVGVAMKGQSEEDPMTSVSLGSAASAAPMASGEDGLSVQAQVSRLISEATSNENLCVHFQGWCPFW
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........--90........100.......110--.--.......120.......130........140.......-150.......160.......170.......180.......190.......200.......210.......220.......230.......-240-.......250.......260......---..270.......280.......290.......300.......310.......320.......330.......340.-......350.......360.........370.......380.-----.---..-----.---..-390.......400.-----------------......410.......420..-..-...430.......440-..--.-....450...-....460-.......---470.......480.-------------------------......490.......500....-.....510----------------------.......520...----.--...530------------------------....--.....540.......550..-----.....560.......570.......580.......590----.......600.......610.......620.......630........640....---..---.-650-.---........660...-.-.-..-670.......680.......690.......700.......----------------------------------710.......720......-.730-........740.-.....-.-750..-.....760.......770.--......780.......790----------------...----------------------------------....800.......810..-.-....820.......-830....------------...840........850......------.860.......870.......880--.......890.......900.....-..910....--...920.......930......-.940.......950...---------------...-.960.......970.......980.......990..----..-...1000......1010......1020......1030..-....---1040-........1050....----..1060......1070.----.....1080......1090......1100......1110......1120......1130......1140......1150......1160......1170...-...1180.-.....1190......--1200.......1210......1220......-1230......1240......1250......1260......1270......1280......1290......1300......1310......1320......1330-----.......1340......1350......1360......1370......1380......1390......1400......1410......1420......1430......1440......1450......1460......1470......1480......1490.....---------.1500......1510......----1520......1530......1540......1550......1560----.......1570......1580-----......1590......1600......1610......1620......1630..-.--.----------..---1640--.......1650.--.--....1660......1670------------------......1680......1690......1700......1710......-----1720......1730-......1740......1750-........1760...------...1770......1780...-...1790......1800......1810......1820......1830-------...--------.-----...1840------......1850......-1860--.--.--......1870......1880......1890......1900......1910......1920......1930......1940......1950......1960.......1970......1980......1990.-.....2000......2010...--------...2020...-.....2030....-.-.2040......2050......2060......2070......2080......2090..-....2100......2110--.......2120...----.-..2130......2140.......2150......2160....--..2170......2180......2190......2200......2210......2220......2230...-.-.-.2240..-....2250.-----.....2260......2270.......2280......2290......2300......2310......2320......2330.....---.2340......2350......2360......2370......2380......2390......2400...-...2410......2420......2430......2440......2450......2460......2470......2480......2490......2500......2510......2520......2530......2540......2550......2560......2570......2580......2590......2600......2610
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MESKGGVGSSNGSGGTSSNRHP
L
I
G
Q
L
R
P
I
F
Q
E
L
E
SAT
P
Q
T
L
P
S
I
I
L
K
L
E
Y
V
I
EEEK
D
A
L
F
H
RNS
I
K
SYTANART
F
P
N
W
L
N
A
Q
L
R
H
L
F
E--QP
Q
T
H
M
A
G
V
Q
V
L
R
A
LLP
V
E
Y
V
-
E
--
L
--
N
E
M
T
K
L
F
S
E
L
L
V
R
C
V
L
ET-ADYNTAVEGG
E
V
W
G
L
L
LNN-
G
S
S
V
V
E
G
I
I
I
N
C
L
Q
F
S
L
A
L
L
MRGGHD
E
I
F
L
REDVSHRGVD
S
E
A
T
V
R
S
A
M
S
P
L
VDSSRQGEN
A
V
LTDDDRFPKATKL
S
G
C
I
F
I
Q
Q
L
V
R
RV
P
-
S
T
I
-
A
P
H
V
H
N
I
L
E
C
L
R
R
A
ILDS-N
K
L
V
R
VS---GG
D
A
L
F
Y
T
L
T
I
S
YRST
D
P
K
F
Y
S
R
W
Q
N
T
F
L
E
D
A
E
R
SVMYG
S
D
V
V
L
H
G
C
L
L
A
F
N
A
V
L
S
A
TASREAEGRAVGFSNQ
G
R
K
-
H
I
L
Q
F
W
T
F
I
ND
N
L
VSTS--HN
S
D
V
R
A
E
V
L
N
A
L
P
L
L
AQYDST
T
-----
F
---
K
E
-----
I
---
S
V
-
K
H
V
R
A
L
A
A
A
V
F
VGT-----------------EGK
D
E
R
A
M
V
F
Q
V
L
A
R
L
F
T
V
L
P
-
S
L
-
V
V
P
F
L
D
F
M
M
K
Y
I
E
ASL-TP--
Q
-
P
L
R
D
RCP
E
A
V
-
T
C
F
A
T
L
S-SVE
P
N
A
V
---
R
P
F
L
R
P
L
L
G
P
L
F
A
G
-------------------------
S
V
T
E
H
F
A
R
D
V
A
K
I
C
T
A
F
--
P
E
L
R
-
S
T
C
L
S
K
V
L
----------------------
E
A
T
K
E
Q
L
L
R
M
RNR----P--RHTS--------------------------ASSE--T
D
H
S
A
I
V
R
S
L
N
SLGSLDFT
G
-----
Y
S
T
L
Q
F
L
C
D
A
V
I
R
YVSD
P
H
E
E
V
R
R
S
A
I
D
L
C
F
K
L
A
LSGC----SQSPCER
T
A
V
G
V
V
I
HRG
R
E
H
L
G
L
V
N
T
V
I
R
K
L
V
S
A
A
VAD-TESD
I
R
L
H
T
L
E
H
L
STE---FD---
Y
-
S
---
L
---
A
L
Q
D
I
C
T
A
L
F
P
A
L
H
-
D
-
H
-
H
Q
-
N
R
I
A
A
V
R
L
L
G
R
L
SSRN
P
S
C
I
L
P
M
L
R
C
V
M
V
Q
C
I
M
D
I
Q
L
FHE----------------------------------P
K
R
Q
E
Q
A
A
V
V
L
S
A
V
V
ESAP-AM
A
--
R
P
Y
I
S
S
L
L
Q
D
C
V
-
T
R
L
Q
E-E-NKP
V
P
-
V
I
T
A
L
L
S
L
V
G
R
L
A
R
YAEDD--D
V
A
V
V
A
A
I
R
P
C
V
I
R
H
IL
D
S
----------------
S
S
I
----------------------------------
Q
K
K
I
E
A
I
R
A
L
G
D
I
I
RTTKD-V-DVYET
N
P
E
L
L
R
V
L
L
-
S
A
L
HGGF------------KETW
P
-
V
R
L
D
V
L
K
L
M
G
I
IGAVDP------
V
R
A
K
E
I
T
R
H
L
R
DGGLSSSGAAA
P
A
--
A
L
Q
LSSSR
G
E
E
A
I
A
Q
N
V
V
K
N
V
L
G
V
L-QLPCLSD
D
Q
--
C
L
C
A
V
Q
V
I
A
N
T
L
S
L
K
E
AA
S
G
C
L
-
T
P
M
Y
R
D
I
L
H
T
V
V
Q
Q
I
T
L
---------------
Q
A
K
-
I
R
E
N
L
F
G
V
M
T
H
I
V
Y
L
Y
G
Q
H
I
R
P
Y
L
D
E
L
I
S
T
C
V
G
F
L
P
----AA-ER
G
V
L
V
E
I
L
C
L
L
R
E
M
R
R
S
L
R
E
EFSPS
L
S
L
V
L
P
P
L
I
Q
T
V
Q-ADAA---HS---SE
P
V
F
A
F
L
I
E
M
G
H
L
L
D
----
D
H
L
H
N
V
V
P
C
V
C
E
V
ASNP----AYP
V
A
C
R
A
A
A
A
D
A
I
R
H
F
A
R
R
L
P
R
L
V
F
H
A
S
R
C
V
H
C
L
C
R
V
L
K
E
MESHP
L
L
F
EQQPGASA
D
A
A
QRRP
A
A
E
LAAGGDT
T
A
S
D
V
R
S
F
V
A
V
T
L
D
A
V
R
V
V
G
R
NLGS
D
F
E
-
K
YT
P
L
V
F
P
-
L
L
DGYGQDGQ
D
V
K
A
F
--
T
-
L
S
T
LRTSGRVVAPENAQ
A
Q
E
E
E
T
A
A
RYRV-
N
T
Q
Q
L
A
Q
R
R
K
A
A
L
E
D
N
F
A
Q
L
R
S
I
L
L
ARDRE
T
E
E
E
W
N
L
W
L
K
Q
L
A
V
E
L
L
RSSPSNA
H
G
F
A
F
A
L
A
Q
L
H
E
P
F
A
R
Q
M
L
H
S
A
F
A
V
C
Y
A
EMEP
R
T
K
E
A
V
R
A
L
L
G
N
V
L
RSD------RV
P
S
E
V
L
Q
E
L
L
N
L
S
E
Y
M
E
R
L
E
M
R
FNPKEGSHS
T
Y
A
G
L
L
F
D
L
K
T
L
MG
S
S
E
R
C
N
F
Y
A
K
A
L
H
Y
V
E
I
Q
F
Y
E
A
T
Y
E
Y
E
R
NVMRGQVRPL
P
P
E
E
W
S
K
L
V
Q
W
C
E
K
S
I
Y
L
C
N
L
LGL
R
E
S
A
E
G
M
L
K
Y
I
Q
R
NFSFLTGKPPSEL
P
L
M
M
D
A
Q
L
L
E
K
L
Q
W
W
S
Q
S
L
R
A
Y
E
KGLQAE
P
N
K
---------
F
S
N
M
V
G
L
M
R
S
L
DNL
G
D
Y
G
R
L
L
----
E
S
W
K
L
F
YPRI
T
R
K
E
A
S
ELAPY
G
A
H
A
A
W
L
L
R
C
W
D
D
M
E
K
I
T
A
Y
MT-----DEGYV
G
T
T
A
V
F
Y
R
A
V
L
A
TH
K
L
-----QFHDA
V
P
V
I
Q
N
C
R
K
R
L
D
S
T
L
S
A
L
V
A
E
S
Y
D
R
A
Y
G
L
F
V
G
I
Q
Q
L
S
E
L
E
E
F
A
FVAD-N--P----------Q
G
---
L
N
H
---
W
Q
E
L
W
E
K
R
L
A
A
M
--A--YEGWPGTLAN
H
T
L
V
I
P
L
A
------------------
Q
E
L
E
M
W
L
R
F
V
S
L
S
R
VHGRDR
T
S
R
D
I
L
F
E
L
LG
K
Q
T
I
A
A
A
LEQPRLPQ-----P
P
I
A
L
A
A
C
Q
H
F
YDI-
N
E
R
E
R
A
V
E
L
L
E
T
Y
L
K
K
M
D
---
Q
AAPS
L
L
DIGG
G
Q
A
S
------
L
A
M
C
H
A
K
L
A
S
W
L
F
T
V
A
K
K
KR-QN
V
D
A
H
Y
R
E
Y
I
R
H
H
L
E
K
ATSLDSTNG
T
I
W
H
T
WARFN
H
D
L
VTHRSRG--------
A
A
S
--------
E
-----
V
R
R
D
E
H
V
------
K
H
I
V
A
A
M
D
G
Y
VRSV
S
C
-
S
--
Q
--
E
--
L
--
E
D
M
L
G
F
L
S
L
W
F
I
H
A
A
L
P
Q
V
Q
ENAA
L
Q
A
E
I
L
QVS
P
T
V
W
L
K
V
L
P
Q
I
I
A
R
L
HSRD
A
V
V
S
E
S
V
F
Q
L
L
T
I
V
A
KAHP
Q
A
L
L
Y
N
L
N
V
T
L
NSSVRGTESN
T
T
E
Q
M
-
E
R
K
Q
A
A
Q
R
L
L
G
R
I
K
E
M
H
NH
G
R
T
M
V
K
D
A
A
L
V
C
Q
E
L
-
V
R
C
A
V
L
W
T
E
L
W
F
D
E
L
E
R
A
W
F
QW--------GRDKN--A
H
N
-
V
F
L
V
L
Q
P
L
L
E
QLS-H-P
N
T
L
A
E
S
H
F
V
A
E
F
G
E
L
L
G
G
A
C
E
Y
V
E
K
A
ASTGN
N
V
Y
M
E
D
A
W
N
R
F
K
T
A
V
K
R
M
D
E
Q
IN
G
M
-
N
S
L
A
L
Q
LV
S
P
R
L
M
QSGK---
D
L
S
L
V
VPGQYNEGG----V-Y
P
R
I
A
S
F
Q
S
T
L
R
V
M
N-SKQHP
R
R
L
Y
M
TGT
D
G
V
L
Y
K
F
L
LKGH--EDL
R
L
D
E
R
V
M
Q
L
L
A
F
V
N
T
L
L
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K
H
S
A
I
Q
RR
D
C
M
I
Q
V
F
S
VTPLSENAG
L
V
G
WVD
N
C
D
T
L
H
Q
L
I
K
D
Y
RVH
S
K
-
Y
-
L
-
S
I
E
M
N
L
M
-
L
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F
NV
D
L
D
R
-----
L
Q
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QHV
E
P
F
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F
A
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EQ-TEG
A
D
L
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L
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MRAP
S
A
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W
L
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RR
T
T
Y
V
C
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L
A
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M
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G
H
I
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GLGDRHPS
N
L
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R
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V
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DFG
D
C
---
F
D
V
AQNRSAFPEK
V
P
F
R
L
T
R
M
L
V
K
A
M
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MGGI
D
G
L
F
RH
G
C
I
T
V
M
G
V
L
R
EE
G
S
S
I
L
A
L
L
E
A
F
VH
D
P
L
V
S
W
-
W
RDESEDGAT
A
S
A
A
VASAAPSSSIPSA
G
A
A
A
A
L
G
H
Y
S
Q
R
A
A
Y
A
A
I
G
E
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F
H
K
S
R
T
AFASRTPASRSLAPRGRSFRAPQTSIASSPSAPPPLVSDR
S
S
D
I
L
S
NMSVNH
T
S
E
A
K
K
V
V
N
R
I
R
E
K
LEGR
E
F
A
A
W
Q
L
QASASAHAADDV
G
V
AMKGQSEEDPM
T
S
VSLGSAASAAPMASGEDG
L
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V
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A
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R
L
I
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E
ATSNE
N
L
C
V
H
FQGWCPFW
57
Fugue
60.73
32%
-15
- C2 -
-
5H64
-
MTOR_HUMAN
A:
[210-2549]
-----------------------
V
A
A
L
R
A
C
L
I
L
T
T
Q
R
E
P
K
E
M
Q
------------------------------------
K
P
Q
W
Y
R
H
T
F
E
--
E
A
E
K
--------------------------------------------------------------------------------------
G
F
D
E
T
L
A
K
E
K
G
M
N
R
D
-----------------------------------
D
R
I
H
G
A
L
L
I
L
N
E
L
V
R
I
S
-
S
M
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-
G
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R
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M
E
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Q
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-
D
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G
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K
P
R
H
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P
F
T
S
F
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A
V
Q
P
Q
Q
S
N
A
L
V
G
L
L
G
Y
S
S
H
Q
G
------------
L
M
G
F
G
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S
P
A
K
S
T
L
V
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S
R
C
C
R
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L
M
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K
F
-
D
Q
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C
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W
V
L
K
C
R
N
----
S
--
K
N
S
L
I
Q
M
T
I
L
N
L
L
P
R
L
A
A
F
R
P
S
A
-----
F
---
T
D
-----
T
---
Q
Y
-
L
------------
Q
-----------------
D
T
M
N
H
V
L
S
C
V
K
V
L
Y
D
L
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R
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-
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D
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L
L
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M
L
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L
V
L
-
M
H
--
K
-
P
L
R
H
P
----------------------------------------------------------------------------------------------------------------------
G
M
P
K
G
L
A
H
Q
L
A
S
----
P
--
G
L
T
T
--------------------------
L
P
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A
--
S
D
V
G
S
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L
A
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T
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F
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-----
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L
----------
L
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P
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V
V
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L
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---
F
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---
A
-
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---
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---
A
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N
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L
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K
M
L
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L
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L
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H
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G
I
----------------------------------
G
R
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K
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W
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I
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M
L
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D
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----------------
S
L
L
----------------------------------
A
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W
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L
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L
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-
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L
L
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V
L
L
-
N
F
L
K
T
--------------
E
Q
N
Q
G
-
T
R
R
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A
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R
V
L
G
L
L
G
A
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L
K
C
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P
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F
L
N
V
I
R
V
---------------
C
D
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A
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----
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---
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----
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----
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D
-----------
Q
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P
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L
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M
D
T
L
S
S
L
V
F
Q
--------------------------
L
G
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-
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F
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P
M
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H
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-----------------
R
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D
V
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K
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K
A
W
G
A
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---------------
R
R
V
S
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D
D
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W
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L
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P
L
P
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D
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--------
N
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---------------
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L
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N
K
-------
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A
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V
L
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A
M
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----------
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L
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L
H
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A
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K
K
M
D
T
N
K
D
D
---------
P
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L
M
L
G
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M
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C
L
E
A
L
G
E
W
G
Q
L
H
----
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C
C
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W
T
L
V
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A
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M
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M
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G
L
G
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M
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-----
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---
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A
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R
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L
A
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-----
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L
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Y
K
L
-
V
--
P
----------
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R
---
R
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I
---
I
R
Q
I
W
W
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L
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G
C
--
Q
RI
V
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W
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K
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M
V
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S
L
V
V
S
P
H
------------------
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D
M
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W
L
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Y
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L
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G
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L
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L
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-----
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A
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M
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N
M
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K
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-
A
R
K
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---
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Q
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L
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K
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W
Q
L
N
L
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------
G
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N
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P
K
V
L
Q
Y
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A
A
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D
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M
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Q
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Q
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DEKK
K
V
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--------
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-----
D
L
S
K
T
L
L
------
M
Y
T
V
P
A
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G
F
F
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--
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---
K
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M
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L
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--------
F
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M
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L
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M
A
P
D
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D
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-----
L
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L
M
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H
A
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N
N
-
T
A
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D
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L
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L
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P
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N
L
M
L
D
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L
S
G
K
I
L
H
I
D
F
G
D
C
---
F
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V
A
M
T
R
E
K
F
P
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K
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P
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L
T
R
M
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A
M
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V
T
G
L
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N
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L
R
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H
K
D
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V
M
A
V
L
E
A
F
V
Y
D
P
L
L
N
W
--------------------------------------------------------------------------------------------------
R
L
M
D
T
N
T
A
L
N
K
K
A
I
Q
I
I
N
R
V
R
D
K
L
T
G
R
D
F
---------------------------------------------
S
H
D
D
T
L
D
V
P
T
Q
V
E
L
L
I
K
Q
A
T
S
H
E
N
L
C
Q
C
Y
I
G
W
C
P
F
W
58
Fugue
59.33
30%
-18
- C2 -
-
5FVM
-
?
A:
[85-2469]
----------------------
N
V
K
A
F
D
L
I
F
T
K
L
N
------------
Q
L
E
R
V
A
A
S
Y
E
L
K
S
C
L
I
S
L
V
S
--
T
E
Y
F
Q
R
F
S
N
D
I
N
N
K
V
F
E
L
I
H
--
D
S
N
E
K
L
G
G
V
L
A
V
D
T
L
I
D
E
L
P
N
-
Q
--
T
--
S
R
L
A
N
Y
L
R
V
L
I
---------
D
I
E
V
M
R
A
A
A
T
T
L
G
K
L
A
V
L
-
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----------
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L
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---
L
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-
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------------
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---
L
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-----------------------
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-
L
L
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-------------------------
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------------------
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L
-----------------
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-------------------------
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--------
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----------------------
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L
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G
-------------------------------------------
T
L
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-----
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------------
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---
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----------------------------------
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----------------
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----------------------------------
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----------
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-
N
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------------------
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L
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------
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----------------------
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----------------------------
P
S
-
L
L
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---
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---
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----
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L
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K
L
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G
---------
N
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R
L
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K
----------------------------------
N
N
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W
D
C
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Q
Q
-------------
R
T
K
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W
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W
I
R
R
L
S
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----
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S
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---
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L
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A
L
S
S
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--------------------
L
L
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L
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M
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H
D
D
K
P
L
P
I
-------------
S
I
S
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L
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Y
A
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C
H
A
Y
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A
L
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L
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-----------------
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P
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-----
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N
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L
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A
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-----------
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L
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T
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K
L
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R
W
D
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A
L
N
A
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N
K
R
E
A
---------------
E
V
T
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G
K
M
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L
H
A
L
G
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W
D
Q
L
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----
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L
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A
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-----
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Q
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---
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A
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F
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L
C
L
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R
N
-----
N
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L
L
V
T
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M
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----
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P
----------
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SER
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---
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V
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------------------
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C
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R
L
G
L
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T
L
N
T
L
L
E
-------------
A
P
-----
P
P
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A
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---
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D
L
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L
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D
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------
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L
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----
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--------
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D
--------
D
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P
L
T
V
A
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K
S
--------------
D
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L
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--------
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L
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P
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Y
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-----
L
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L
L
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V
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A
L
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N
-
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L
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L
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V
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I
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F
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---
F
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A
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P
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K
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L
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M
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L
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A
F
A
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D
P
L
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N
W
-
G
F
D
L
P
T
H
-----------------------------------------------
A
V
M
E
Q
T
G
I
D
L
P
L
A
N
P
S
E
L
L
R
K
G
V
I
S
V
E
D
A
A
K
M
E
-----------
L
Q
Q
K
A
E
V
R
N
A
R
A
T
L
V
L
K
R
I
A
D
K
L
T
G
N
D
F
---------------------------------------------
P
R
C
Q
E
L
S
V
P
D
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V
D
K
L
I
Q
Q
A
T
S
V
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N
L
C
Q
H
Y
I
G
W
C
S
--
22
HHSearch
53.25
29%
-11
- C2 -
-
6EMK
-
TOR2_YEAST
A:
[126-2474]
--------------------------------------------------------------------------
R
F
S
N
S
L
N
N
K
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F
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L
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H
GF
T
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-----
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T
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D
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----------------------------
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----
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---
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-------------
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K
Y
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A
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---
A
K
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L
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L
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C------------------------
P
M
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--
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----------------------
N
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----
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---
C
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A
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---
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--------------
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-------------------------------------------------
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C--------------
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-------------
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---------------------
N
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---------
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--------------------------------
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---
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--
Q
L
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-
N
-------------
A
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--
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L
L
S
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G
-----------
A
------------
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--
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---------------------------------------------
N
D
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W
1
PsiBlast_PDB
49.86
27%
-21
- C2 -
-
6EMK
-
TOR2_YEAST
A:
[242-2373]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
L
L
I
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K
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A
D
N
S
P
-
Y
L
L
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N
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W
V
P
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D
A
-
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L
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L
D
---
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I
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I
Q
D
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D
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----------------
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---
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N
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A
A
-----------------
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M
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-------------------------
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----------------------------------
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---------------
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-------------------------------------------------
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------------------------------
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K
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L
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R
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----
V
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--
D
-
Q
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L
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N
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Y
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M
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L
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L
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Y
Y
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L
A
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L
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N
A
S
F
S
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C
W
V
E
L
Q
T
S
Y
Q
E
D
------------------------------
L
V
E
F
M
E
H
D
D
-------------
K
P
L
P
I
P
I
H
T
L
G
K
Y
A
Q
K
C
H
A
F
A
K
A
L
H
Y
K
E
V
E
F
L
E
E
-----------------
P
K
N
S
T
-----
I
E
A
L
I
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I
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N
Q
L
H
Q
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D
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A
I
G
I
L
K
H
A
Q
Q
H
N
E
-----------
L
Q
L
K
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T
W
Y
E
K
L
Q
R
W
E
D
A
L
A
A
Y
N
E
K
E
A
A
G
E
D
S
---------
V
E
V
M
M
G
K
L
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L
Y
A
L
G
E
W
E
E
L
S
K
L
AS
E
K
W
G
T
A
K
P
E
V
K
K
A
M
A
P
L
----
A
A
G
A
A
W
G
L
E
Q
W
D
E
I
A
Q
Y
T
S
V
M
K
-----
S
Q
S
---
P
D
K
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F
Y
D
A
I
L
C
L
H
R
N
-----
N
F
K
K
A
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V
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I
F
N
A
R
D
L
L
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T
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L
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Y
K
K
-
L
--
P
----------
Q
N
---
S
D
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M
R
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T
W
N
T
R
L
L
G
C
--
Q
KN
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W
Q
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I
L
R
V
R
S
L
V
I
K
P
K
------------------
E
D
A
Q
V
R
I
K
F
A
N
L
C
R
K
S
G
R
M
A
L
A
K
K
V
L
------
N
T
L
L
E
E
T
D
D
P
D
H
P
N
TAKAS
P
P
V
V
Y
A
Q
L
K
Y
L
W
A
T
-
G
L
Q
D
E
A
L
K
Q
L
I
N
F
T
S
R
M
A
HDL--------
V
E
D
Y
T
K
L
------
L
A
R
C
F
L
K
Q
G
E
W
R
V
C
L
Q
P
K
W
R
L
S
N
P
D
S
I
L
G
S
Y
L
L
-----
A
T
H
F
D
N
T
W
Y
K
A
W
H
N
W
A
L
A
N
F
E
V
I
S
----------------------------------
S
N
L
IH----
R
H
V
I
P
A
I
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G
F
F
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-
S
--
E
--
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--
S
SL
Q
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--
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L
L
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L
L
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L
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A
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A
L
V
Y
P
L
M
V
A
I
K
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----------
E
S
L
-
S
R
Q
K
A
A
---
L
S
I
I
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K
M
R
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H
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V
L
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D
Q
A
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L
V
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M
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W
Y
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G
L
D
D
A
S
R
Q
F
--------
F
G
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N
--
T
E
K
-
M
F
A
A
L
E
P
L
Y
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M
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L
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I
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F
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D
A
Y
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W
L
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N
Y
K
K
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N
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A
W
D
I
Y
Y
N
V
F
R
K
I
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Q
L
P
Q
L
-
Q
T
L
E
L
Q
H
V
S
P
K
L
L
-
S
A
H
---
D
L
E
L
A
V
P
G
T
R
A
S
G
G
----
K
P
I
V
K
I
S
K
F
E
P
V
F
S
V
I
S
-
S
K
Q
R
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G
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D
G
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D
Y
K
Y
V
L
K
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--
E
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I
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D
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L
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M
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C
F
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R
H
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G
L
L
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A
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-
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-
N
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M
-
L
Q
M
A
P
D
Y
D
N
-----
L
T
L
L
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V
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F
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Y
A
L
N
N
-
T
E
G
Q
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V
L
W
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R
S
S
E
T
W
L
E
R
R
T
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Y
T
R
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L
A
V
M
S
M
T
G
Y
I
L
G
L
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P
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N
L
M
L
D
R
I
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G
K
V
I
H
I
D
F
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D
C
---
F
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A
A
I
L
R
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K
F
P
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K
V
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F
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M
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A
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A
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F
A
F
D
P
L
I
N
W
-
G
F
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
Fugue
48.80
39%
-23
- C2 -
-
4JSP
1
MTOR_HUMAN
A:
[10-1174]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
A
A
K
C
R
A
Y
A
K
A
L
H
Y
K
E
L
E
F
Q
K
G
P
---------------
T
P
A
I
L
E
S
L
I
S
I
N
N
K
-------
L
Q
Q
P
E
A
A
A
G
V
L
E
Y
A
M
K
H
F
G
----------
E
L
E
I
Q
A
T
W
Y
E
K
L
H
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W
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D
A
L
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A
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K
M
D
T
N
K
D
D
---------
P
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L
M
L
G
R
M
R
C
L
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A
L
G
E
W
G
Q
L
H
----
Q
Q
C
C
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L
V
N
D
E
T
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A
K
M
A
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L
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M
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E
Y
T
C
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-----
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---
H
D
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A
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Y
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A
V
L
A
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-----
L
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A
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Q
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D
K
A
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Y
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A
Y
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--
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----------
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---
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---
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------------------
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---
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C
F
L
K
L
G
E
W
Q
L
N
L
Q
------
G
I
N
E
S
T
I
P
K
V
L
Q
Y
Y
S
A
A
T
E
H
D
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W
Y
K
A
W
H
A
W
A
V
M
N
F
E
A
V
L
H
Y
K
H
Q
--------
N
Q
A
R
D
E
KK
K
V
T
E
-----
D
L
S
K
T
L
L
------
M
Y
T
V
P
A
V
Q
G
F
F
R
S
I
S
L
-
S
--
R
--
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NN
L
--
Q
D
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L
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Y
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W
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--
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A
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I
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L
Q
V
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R
L
I
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Q
L
L
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D
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Y
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P
Q
A
L
I
Y
P
L
T
V
A
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K
S
T
----------
T
T
-
A
R
H
N
A
A
N
K
I
L
---
K
N
M
C
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L
V
Q
Q
A
M
M
V
S
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W
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G
L
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A
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L
Y
--------
F
G
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N
--
V
K
G
-
M
F
E
V
L
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P
L
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A
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G
P
Q
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L
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N
Q
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L
Y
Y
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F
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R
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Q
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L
Q
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V
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P
K
L
L
M
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C
R
---
D
L
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L
A
V
P
G
T
Y
D
P
N
Q
----
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-
I
I
R
I
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S
I
A
P
S
L
Q
V
I
T
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S
K
Q
R
P
R
K
L
T
L
M
G
S
N
G
H
E
F
V
F
L
L
K
G
H
--
E
D
L
R
Q
D
E
R
V
M
Q
L
F
G
L
V
N
T
L
L
A
N
D
P
T
S
L
R
K
N
L
S
I
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Y
A
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T
N
S
G
L
I
G
W
V
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D
Y
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K
-
I
-
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L
N
I
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-
L
R
M
A
P
D
Y
D
H
-----
L
T
L
M
Q
K
V
E
V
F
E
H
A
V
N
N
-
T
A
G
D
D
L
A
K
L
L
W
L
K
S
P
S
S
E
V
W
F
D
R
R
T
N
Y
T
R
S
L
A
V
M
S
M
V
G
Y
I
L
G
L
G
D
R
H
P
S
N
L
M
L
D
R
L
S
G
K
I
L
H
I
D
F
G
D
C
---
F
E
V
A
M
T
R
E
K
F
P
E
K
I
P
F
R
L
T
R
M
L
T
N
A
M
E
V
T
G
L
D
G
N
Y
R
I
T
C
H
T
V
M
E
V
L
R
E
H
K
D
S
V
M
A
V
L
E
A
F
V
Y
D
P
L
L
N
W
-
R
-------------------------------------------------------------------------------------------------
L
M
D
T
N
T
A
L
N
K
K
A
I
Q
I
I
N
R
V
R
D
K
L
T
G
R
D
F
---------------------------------------------
S
H
D
D
T
L
D
V
P
T
Q
V
E
L
L
I
K
Q
A
T
S
H
E
N
L
C
Q
C
Y
I
G
W
C
P
F
W
6
PsiBlast_PDB
46.83
39%
-21
- C2 -
-
4JSV
2
B:
[505-1174]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
V
P
A
V
Q
G
F
F
R
S
I
S
L
-
S
--
R
GN
N
--
L
--
Q
D
T
L
R
V
L
T
L
W
F
D
Y
G
H
W
P
D
V
--
N
E
A
L
V
E
G
V
K
A
I
Q
I
D
T
W
L
Q
V
I
P
Q
L
I
A
R
I
D
T
P
R
P
L
V
G
R
L
I
H
Q
L
L
T
D
I
G
R
Y
H
P
Q
A
L
I
Y
P
L
T
V
-------
A
S
K
S
T
T
T
A
----
R
H
N
A
A
N
K
I
L
---
K
N
M
C
E
H
S
N
T
L
V
Q
Q
A
M
M
V
S
E
E
L
-
I
R
V
A
I
L
W
H
E
M
W
H
E
G
L
E
E
A
S
R
L
Y
--------
F
G
E
R
N
--
V
K
G
-
M
F
E
V
L
E
P
L
H
A
M
M
E
-
R
G
P
Q
T
L
K
E
T
S
F
N
Q
A
Y
G
R
D
L
M
E
A
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C
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Y
M
K
S
G
N
V
K
D
L
T
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A
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L
Y
Y
H
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F
R
R
I
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Q
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L
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K
L
L
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C
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---
D
L
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A
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Y
D
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N
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----
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-
I
I
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I
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I
A
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G
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F
V
F
L
L
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L
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W
V
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H
C
D
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L
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A
L
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D
Y
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K
K
-
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L
L
N
I
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R
I
M
-
L
R
M
A
P
D
Y
D
H
-----
L
T
L
M
Q
K
V
E
V
F
E
H
A
V
N
N
-
T
A
G
D
D
L
A
K
L
L
W
L
K
S
P
S
S
E
V
W
F
D
R
R
T
N
Y
T
R
S
L
A
V
M
S
M
V
G
Y
I
L
G
L
G
D
R
H
P
S
N
L
M
L
D
R
L
S
G
K
I
L
H
I
D
F
G
D
C
---
F
E
V
A
M
T
R
E
K
F
P
E
K
I
P
F
R
L
T
R
M
L
T
N
A
M
E
V
T
G
L
D
G
N
Y
R
I
T
C
H
T
V
M
E
V
L
R
E
H
K
D
S
V
M
A
V
L
E
A
F
V
Y
D
P
L
L
N
W
R
L
M
D
T
N
T
----------------------------------------------------------------------------------
A
L
----------------
N
K
K
A
I
Q
I
I
N
R
V
R
D
K
L
T
G
R
D
F
---------------------------------------------
S
H
D
D
T
L
D
V
P
T
Q
V
E
L
L
I
K
Q
A
T
S
H
E
N
L
C
Q
C
Y
I
G
W
C
P
F
W
12
PsiBlast_PDB
46.37
39%
-20
- C2 -
-
5WBY
-
B:
[508-1177]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
V
P
A
V
Q
G
F
F
R
S
I
S
L
-
S
--
R
GN
N
--
L
--
Q
D
T
L
R
V
L
T
L
W
F
D
Y
G
H
W
P
D
V
--
N
E
A
L
V
E
G
V
K
A
I
Q
I
D
T
W
L
Q
V
I
P
Q
L
I
A
R
I
D
T
P
R
P
L
V
G
R
L
I
H
Q
L
L
T
D
I
G
R
Y
H
P
Q
A
L
I
Y
P
L
T
V
-------
A
S
K
S
T
T
T
A
----
R
H
N
A
A
N
K
I
L
---
K
N
M
C
E
H
S
N
T
L
V
Q
Q
A
M
M
V
S
E
E
L
-
I
R
V
A
I
L
W
H
E
M
W
H
E
G
L
E
E
A
S
R
L
Y
--------
F
G
E
R
N
--
V
K
G
-
M
F
E
V
L
E
P
L
H
A
M
M
E
-
R
G
P
Q
T
L
K
E
T
S
F
N
Q
A
Y
G
R
D
L
M
E
A
Q
E
W
C
R
K
Y
M
K
S
G
N
V
K
D
L
T
Q
A
W
D
L
Y
Y
H
V
F
R
R
I
S
K
Q
L
P
Q
L
-
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S
L
E
L
Q
Y
V
S
P
K
L
L
M
C
-
R
---
D
L
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L
A
V
P
G
T
Y
D
P
N
Q
----
P
-
I
I
R
I
Q
S
I
A
P
S
L
Q
V
I
T
-
S
K
Q
R
P
R
K
L
T
L
M
G
S
N
G
H
E
F
V
F
L
L
K
G
H
--
E
D
L
R
Q
D
E
R
V
M
Q
L
F
G
L
V
N
T
L
L
A
N
D
P
T
S
L
R
K
N
L
S
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Y
A
V
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L
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T
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L
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G
W
V
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C
D
T
L
H
A
L
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D
Y
R
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K
K
K
-
I
-
L
L
N
I
E
H
R
I
M
-
L
R
M
A
P
D
Y
D
H
-----
L
T
L
M
Q
K
V
E
V
F
E
H
A
V
N
N
-
T
A
G
D
D
L
A
K
L
L
W
L
K
S
P
S
S
E
V
W
F
D
R
R
T
N
Y
T
R
S
L
A
V
M
S
M
V
G
Y
I
L
G
L
G
D
R
H
P
S
N
L
M
L
D
R
L
S
G
K
I
L
H
I
D
F
G
D
C
---
F
E
V
A
M
T
R
E
K
F
P
E
K
I
P
F
R
L
T
R
M
L
T
N
A
M
E
V
T
G
L
D
G
N
Y
R
I
T
C
H
T
V
M
E
V
L
R
E
H
K
D
S
V
M
A
V
L
E
A
F
V
Y
D
P
L
L
N
W
R
L
M
D
T
N
T
----------------------------------------------------------------------------------
A
L
----------------
N
K
K
A
I
Q
I
I
N
R
V
R
D
K
L
T
G
R
D
F
---------------------------------------------
S
H
D
D
T
L
D
V
P
T
Q
V
E
L
L
I
K
Q
A
T
S
H
E
N
L
C
Q
C
Y
I
G
W
C
P
F
W
11
PsiBlast_PDB
46.29
39%
-20
- C2 -
-
5WBU
-
B:
[508-1177]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
V
P
A
V
Q
G
F
F
R
S
I
S
L
-
S
--
R
GN
N
--
L
--
Q
D
T
L
R
V
L
T
L
W
F
D
Y
G
H
W
P
D
V
--
N
E
A
L
V
E
G
V
K
A
I
Q
I
D
T
W
L
Q
V
I
P
Q
L
I
A
R
I
D
T
P
R
P
L
V
G
R
L
I
H
Q
L
L
T
D
I
G
R
Y
H
P
Q
A
L
I
Y
P
L
T
V
-------
A
S
K
S
T
T
T
A
----
R
H
N
A
A
N
K
I
L
---
K
N
M
C
E
H
S
N
T
L
V
Q
Q
A
M
M
V
S
E
E
L
-
I
R
V
A
I
L
W
H
E
M
W
H
E
G
L
E
E
A
S
R
L
Y
--------
F
G
E
R
N
--
V
K
G
-
M
F
E
V
L
E
P
L
H
A
M
M
E
-
R
G
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Q
T
L
K
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F
N
Q
A
Y
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R
D
L
M
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A
Q
E
W
C
R
K
Y
M
K
S
G
N
V
K
D
L
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Q
A
W
D
L
Y
Y
H
V
F
R
R
I
S
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Q
L
P
Q
L
-
T
S
L
E
L
Q
Y
V
S
P
K
L
L
M
C
-
R
---
D
L
E
L
A
V
P
G
T
Y
D
P
N
Q
----
P
-
I
I
R
I
Q
S
I
A
P
S
L
Q
V
I
T
-
S
K
Q
R
P
R
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L
T
L
M
G
S
N
G
H
E
F
V
F
L
L
K
G
H
--
E
D
L
R
Q
D
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R
V
M
Q
L
F
G
L
V
N
T
L
L
A
N
D
P
T
S
L
R
K
N
L
S
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A
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L
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W
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D
T
L
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A
L
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D
Y
R
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K
K
K
-
I
-
L
L
N
I
E
H
R
I
M
-
L
R
M
A
P
D
Y
D
H
-----
L
T
L
M
Q
K
V
E
V
F
E
H
A
V
N
N
-
T
A
G
D
D
L
A
K
L
L
W
L
K
S
P
S
S
E
V
W
F
D
R
R
T
N
Y
T
R
S
L
A
V
M
S
M
V
G
Y
I
L
G
L
G
D
R
H
P
S
N
L
M
L
D
R
L
S
G
K
I
L
H
I
D
F
G
D
C
---
F
E
V
A
M
T
R
E
K
F
P
E
K
I
P
F
R
L
T
R
M
L
T
N
A
M
E
V
T
G
L
D
G
N
Y
R
I
T
C
H
T
V
M
E
V
L
R
E
H
K
D
S
V
M
A
V
L
E
A
F
V
Y
D
P
L
L
N
W
R
L
M
D
T
N
T
----------------------------------------------------------------------------------
A
L
----------------
N
K
K
A
I
Q
I
I
N
R
V
R
D
K
L
T
G
R
D
F
---------------------------------------------
S
H
D
D
T
L
D
V
P
T
Q
V
E
L
L
I
K
Q
A
T
S
H
E
N
L
C
Q
C
Y
I
G
W
C
P
F
W
9
PsiBlast_PDB
45.94
39%
-16
- C2 -
-
4JT5
1
B:
[505-1174]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
V
P
A
V
Q
G
F
F
R
S
I
S
L
-
S
--
R
GN
N
--
L
--
Q
D
T
L
R
V
L
T
L
W
F
D
Y
G
H
W
P
D
V
--
N
E
A
L
V
E
G
V
K
A
I
Q
I
D
T
W
L
Q
V
I
P
Q
L
I
A
R
I
D
T
P
R
P
L
V
G
R
L
I
H
Q
L
L
T
D
I
G
R
Y
H
P
Q
A
L
I
Y
P
L
T
V
-------
A
S
K
S
T
T
T
A
----
R
H
N
A
A
N
K
I
L
---
K
N
M
C
E
H
S
N
T
L
V
Q
Q
A
M
M
V
S
E
E
L
-
I
R
V
A
I
L
W
H
E
M
W
H
E
G
L
E
E
A
S
R
L
Y
--------
F
G
E
R
N
--
V
K
G
-
M
F
E
V
L
E
P
L
H
A
M
M
E
-
R
G
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Q
T
L
K
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T
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F
N
Q
A
Y
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R
D
L
M
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Q
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W
C
R
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Y
M
K
S
G
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K
D
L
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A
W
D
L
Y
Y
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V
F
R
R
I
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Q
L
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Q
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-
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S
L
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L
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S
P
K
L
L
M
C
-
R
---
D
L
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L
A
V
P
G
T
Y
D
P
N
Q
----
P
-
I
I
R
I
Q
S
I
A
P
S
L
Q
V
I
T
-
S
K
Q
R
P
R
K
L
T
L
M
G
S
N
G
H
E
F
V
F
L
L
K
G
H
--
E
D
L
R
Q
D
E
R
V
M
Q
L
F
G
L
V
N
T
L
L
A
N
D
P
T
S
L
R
K
N
L
S
I
Q
R
Y
A
V
I
P
L
S
T
N
S
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L
I
G
W
V
P
H
C
D
T
L
H
A
L
I
R
D
Y
R
E
K
K
K
-
I
-
L
L
N
I
E
H
R
I
M
-
L
R
M
A
P
D
Y
D
H
-----
L
T
L
M
Q
K
V
E
V
F
E
H
A
V
N
N
-
T
A
G
D
D
L
A
K
L
L
W
L
K
S
P
S
S
E
V
W
F
D
R
R
T
N
Y
T
R
S
L
A
V
M
S
M
V
G
Y
I
L
G
L
G
D
R
H
P
S
N
L
M
L
D
R
L
S
G
K
I
L
H
I
D
F
G
D
C
---
F
E
V
A
M
T
R
E
K
F
P
E
K
I
P
F
R
L
T
R
M
L
T
N
A
M
E
V
T
G
L
D
G
N
Y
R
I
T
C
H
T
V
M
E
V
L
R
E
H
K
D
S
V
M
A
V
L
E
A
F
V
Y
D
P
L
L
N
W
R
L
M
D
T
N
T
----------------------------------------------------------------------------------
A
L
----------------
N
K
K
A
I
Q
I
I
N
R
V
R
D
K
L
T
G
R
D
F
---------------------------------------------
S
H
D
D
T
L
D
V
P
T
Q
V
E
L
L
I
K
Q
A
T
S
H
E
N
L
C
Q
C
Y
I
G
W
C
P
F
W
8
PsiBlast_PDB
45.88
39%
-18
- C2 -
-
4JSX
1
B:
[505-1174]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
V
P
A
V
Q
G
F
F
R
S
I
S
L
-
S
--
R
GN
N
--
L
--
Q
D
T
L
R
V
L
T
L
W
F
D
Y
G
H
W
P
D
V
--
N
E
A
L
V
E
G
V
K
A
I
Q
I
D
T
W
L
Q
V
I
P
Q
L
I
A
R
I
D
T
P
R
P
L
V
G
R
L
I
H
Q
L
L
T
D
I
G
R
Y
H
P
Q
A
L
I
Y
P
L
T
V
-------
A
S
K
S
T
T
T
A
----
R
H
N
A
A
N
K
I
L
---
K
N
M
C
E
H
S
N
T
L
V
Q
Q
A
M
M
V
S
E
E
L
-
I
R
V
A
I
L
W
H
E
M
W
H
E
G
L
E
E
A
S
R
L
Y
--------
F
G
E
R
N
--
V
K
G
-
M
F
E
V
L
E
P
L
H
A
M
M
E
-
R
G
P
Q
T
L
K
E
T
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F
N
Q
A
Y
G
R
D
L
M
E
A
Q
E
W
C
R
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Y
M
K
S
G
N
V
K
D
L
T
Q
A
W
D
L
Y
Y
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F
R
R
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P
Q
L
-
T
S
L
E
L
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K
L
L
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C
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---
D
L
E
L
A
V
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G
T
Y
D
P
N
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----
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-
I
I
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I
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S
I
A
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S
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S
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Q
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L
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W
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L
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A
L
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Y
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K
K
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I
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L
L
N
I
E
H
R
I
M
-
L
R
M
A
P
D
Y
D
H
-----
L
T
L
M
Q
K
V
E
V
F
E
H
A
V
N
N
-
T
A
G
D
D
L
A
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L
L
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R
R
T
N
Y
T
R
S
L
A
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M
V
G
Y
I
L
G
L
G
D
R
H
P
S
N
L
M
L
D
R
L
S
G
K
I
L
H
I
D
F
G
D
C
---
F
E
V
A
M
T
R
E
K
F
P
E
K
I
P
F
R
L
T
R
M
L
T
N
A
M
E
V
T
G
L
D
G
N
Y
R
I
T
C
H
T
V
M
E
V
L
R
E
H
K
D
S
V
M
A
V
L
E
A
F
V
Y
D
P
L
L
N
W
R
L
M
D
T
N
T
----------------------------------------------------------------------------------
A
L
----------------
N
K
K
A
I
Q
I
I
N
R
V
R
D
K
L
T
G
R
D
F
---------------------------------------------
S
H
D
D
T
L
D
V
P
T
Q
V
E
L
L
I
K
Q
A
T
S
H
E
N
L
C
Q
C
Y
I
G
W
C
P
F
W
10
PsiBlast_PDB
45.80
39%
-20
- C2 -
-
4JT6
1
B:
[505-1174]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
V
P
A
V
Q
G
F
F
R
S
I
S
L
-
S
--
R
GN
N
--
L
--
Q
D
T
L
R
V
L
T
L
W
F
D
Y
G
H
W
P
D
V
--
N
E
A
L
V
E
G
V
K
A
I
Q
I
D
T
W
L
Q
V
I
P
Q
L
I
A
R
I
D
T
P
R
P
L
V
G
R
L
I
H
Q
L
L
T
D
I
G
R
Y
H
P
Q
A
L
I
Y
P
L
T
V
-------
A
S
K
S
T
T
T
A
----
R
H
N
A
A
N
K
I
L
---
K
N
M
C
E
H
S
N
T
L
V
Q
Q
A
M
M
V
S
E
E
L
-
I
R
V
A
I
L
W
H
E
M
W
H
E
G
L
E
E
A
S
R
L
Y
--------
F
G
E
R
N
--
V
K
G
-
M
F
E
V
L
E
P
L
H
A
M
M
E
-
R
G
P
Q
T
L
K
E
T
S
F
N
Q
A
Y
G
R
D
L
M
E
A
Q
E
W
C
R
K
Y
M
K
S
G
N
V
K
D
L
T
Q
A
W
D
L
Y
Y
H
V
F
R
R
I
S
K
Q
L
P
Q
L
-
T
S
L
E
L
Q
Y
V
S
P
K
L
L
M
C
-
R
---
D
L
E
L
A
V
P
G
T
Y
D
P
N
Q
----
P
-
I
I
R
I
Q
S
I
A
P
S
L
Q
V
I
T
-
S
K
Q
R
P
R
K
L
T
L
M
G
S
N
G
H
E
F
V
F
L
L
K
G
H
--
E
D
L
R
Q
D
E
R
V
M
Q
L
F
G
L
V
N
T
L
L
A
N
D
P
T
S
L
R
K
N
L
S
I
Q
R
Y
A
V
I
P
L
S
T
N
S
G
L
I
G
W
V
P
H
C
D
T
L
H
A
L
I
R
D
Y
R
E
K
K
K
-
I
-
L
L
N
I
E
H
R
I
M
-
L
R
M
A
P
D
Y
D
H
-----
L
T
L
M
Q
K
V
E
V
F
E
H
A
V
N
N
-
T
A
G
D
D
L
A
K
L
L
W
L
K
S
P
S
S
E
V
W
F
D
R
R
T
N
Y
T
R
S
L
A
V
M
S
M
V
G
Y
I
L
G
L
G
D
R
H
P
S
N
L
M
L
D
R
L
S
G
K
I
L
H
I
D
F
G
D
C
---
F
E
V
A
M
T
R
E
K
F
P
E
K
I
P
F
R
L
T
R
M
L
T
N
A
M
E
V
T
G
L
D
G
N
Y
R
I
T
C
H
T
V
M
E
V
L
R
E
H
K
D
S
V
M
A
V
L
E
A
F
V
Y
D
P
L
L
N
W
R
L
M
D
T
N
T
----------------------------------------------------------------------------------
A
L
----------------
N
K
K
A
I
Q
I
I
N
R
V
R
D
K
L
T
G
R
D
F
---------------------------------------------
S
H
D
D
T
L
D
V
P
T
Q
V
E
L
L
I
K
Q
A
T
S
H
E
N
L
C
Q
C
Y
I
G
W
C
P
F
W
5
PsiBlast_PDB
45.68
39%
-18
- C2 -
-
4JSP
1
B:
[505-1174]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
V
P
A
V
Q
G
F
F
R
S
I
S
L
-
S
--
R
GN
N
--
L
--
Q
D
T
L
R
V
L
T
L
W
F
D
Y
G
H
W
P
D
V
--
N
E
A
L
V
E
G
V
K
A
I
Q
I
D
T
W
L
Q
V
I
P
Q
L
I
A
R
I
D
T
P
R
P
L
V
G
R
L
I
H
Q
L
L
T
D
I
G
R
Y
H
P
Q
A
L
I
Y
P
L
T
V
-------
A
S
K
S
T
T
T
A
----
R
H
N
A
A
N
K
I
L
---
K
N
M
C
E
H
S
N
T
L
V
Q
Q
A
M
M
V
S
E
E
L
-
I
R
V
A
I
L
W
H
E
M
W
H
E
G
L
E
E
A
S
R
L
Y
--------
F
G
E
R
N
--
V
K
G
-
M
F
E
V
L
E
P
L
H
A
M
M
E
-
R
G
P
Q
T
L
K
E
T
S
F
N
Q
A
Y
G
R
D
L
M
E
A
Q
E
W
C
R
K
Y
M
K
S
G
N
V
K
D
L
T
Q
A
W
D
L
Y
Y
H
V
F
R
R
I
S
K
Q
L
P
Q
L
-
T
S
L
E
L
Q
Y
V
S
P
K
L
L
M
C
-
R
---
D
L
E
L
A
V
P
G
T
Y
D
P
N
Q
----
P
-
I
I
R
I
Q
S
I
A
P
S
L
Q
V
I
T
-
S
K
Q
R
P
R
K
L
T
L
M
G
S
N
G
H
E
F
V
F
L
L
K
G
H
--
E
D
L
R
Q
D
E
R
V
M
Q
L
F
G
L
V
N
T
L
L
A
N
D
P
T
S
L
R
K
N
L
S
I
Q
R
Y
A
V
I
P
L
S
T
N
S
G
L
I
G
W
V
P
H
C
D
T
L
H
A
L
I
R
D
Y
R
E
K
K
K
-
I
-
L
L
N
I
E
H
R
I
M
-
L
R
M
A
P
D
Y
D
H
-----
L
T
L
M
Q
K
V
E
V
F
E
H
A
V
N
N
-
T
A
G
D
D
L
A
K
L
L
W
L
K
S
P
S
S
E
V
W
F
D
R
R
T
N
Y
T
R
S
L
A
V
M
S
M
V
G
Y
I
L
G
L
G
D
R
H
P
S
N
L
M
L
D
R
L
S
G
K
I
L
H
I
D
F
G
D
C
---
F
E
V
A
M
T
R
E
K
F
P
E
K
I
P
F
R
L
T
R
M
L
T
N
A
M
E
V
T
G
L
D
G
N
Y
R
I
T
C
H
T
V
M
E
V
L
R
E
H
K
D
S
V
M
A
V
L
E
A
F
V
Y
D
P
L
L
N
W
R
L
M
D
T
N
T
----------------------------------------------------------------------------------
A
L
----------------
N
K
K
A
I
Q
I
I
N
R
V
R
D
K
L
T
G
R
D
F
---------------------------------------------
S
H
D
D
T
L
D
V
P
T
Q
V
E
L
L
I
K
Q
A
T
S
H
E
N
L
C
Q
C
Y
I
G
W
C
P
F
W
2
PsiBlast_PDB
44.78
39%
-17
- C2 -
-
5H64
-
MTOR_HUMAN
A:
[1880-2549]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
V
P
A
V
Q
G
F
F
R
S
I
S
L
-
S
--
R
GN
N
--
L
--
Q
D
T
L
R
V
L
T
L
W
F
D
Y
G
H
W
P
D
V
--
N
E
A
L
V
E
G
V
K
A
I
Q
I
D
T
W
L
Q
V
I
P
Q
L
I
A
R
I
D
T
P
R
P
L
V
G
R
L
I
H
Q
L
L
T
D
I
G
R
Y
H
P
Q
A
L
I
Y
P
L
T
V
-------
A
S
K
S
T
T
T
A
----
R
H
N
A
A
N
K
I
L
---
K
N
M
C
E
H
S
N
T
L
V
Q
Q
A
M
M
V
S
E
E
L
-
I
R
V
A
I
L
W
H
E
M
W
H
E
G
L
E
E
A
S
R
L
Y
--------
F
G
E
R
N
--
V
K
G
-
M
F
E
V
L
E
P
L
H
A
M
M
E
-
R
G
P
Q
T
L
K
E
T
S
F
N
Q
A
Y
G
R
D
L
M
E
A
Q
E
W
C
R
K
Y
M
K
S
G
N
V
K
D
L
T
Q
A
W
D
L
Y
Y
H
V
F
R
R
I
S
K
Q
L
P
Q
L
-
T
S
L
E
L
Q
Y
V
S
P
K
L
L
M
C
-
R
---
D
L
E
L
A
V
P
G
T
Y
D
P
N
Q
----
P
-
I
I
R
I
Q
S
I
A
P
S
L
Q
V
I
T
-
S
K
Q
R
P
R
K
L
T
L
M
G
S
N
G
H
E
F
V
F
L
L
K
G
H
--
E
D
L
R
Q
D
E
R
V
M
Q
L
F
G
L
V
N
T
L
L
A
N
D
P
T
S
L
R
K
N
L
S
I
Q
R
Y
A
V
I
P
L
S
T
N
S
G
L
I
G
W
V
P
H
C
D
T
L
H
A
L
I
R
D
Y
R
E
K
K
K
-
I
-
L
L
N
I
E
H
R
I
M
-
L
R
M
A
P
D
Y
D
H
-----
L
T
L
M
Q
K
V
E
V
F
E
H
A
V
N
N
-
T
A
G
D
D
L
A
K
L
L
W
L
K
S
P
S
S
E
V
W
F
D
R
R
T
N
Y
T
R
S
L
A
V
M
S
M
V
G
Y
I
L
G
L
G
D
R
H
P
S
N
L
M
L
D
R
L
S
G
K
I
L
H
I
D
F
G
D
C
---
F
E
V
A
M
T
R
E
K
F
P
E
K
I
P
F
R
L
T
R
M
L
T
N
A
M
E
V
T
G
L
D
G
N
Y
R
I
T
C
H
T
V
M
E
V
L
R
E
H
K
D
S
V
M
A
V
L
E
A
F
V
Y
D
P
L
L
N
W
R
L
M
D
T
N
T
----------------------------------------------------------------------------------
A
L
----------------
N
K
K
A
I
Q
I
I
N
R
V
R
D
K
L
T
G
R
D
F
---------------------------------------------
S
H
D
D
T
L
D
V
P
T
Q
V
E
L
L
I
K
Q
A
T
S
H
E
N
L
C
Q
C
Y
I
G
W
C
P
F
W
3
PsiBlast_PDB
42.18
39%
-23
- C2 -
-
3JBZ
2
A:
[496-1165]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
V
P
A
V
Q
G
F
F
R
S
I
S
L
-
S
--
R
GN
N
--
L
--
Q
D
T
L
R
V
L
T
L
W
F
D
Y
G
H
W
P
D
V
--
N
E
A
L
V
E
G
V
K
A
I
Q
I
D
T
W
L
Q
V
I
P
Q
L
I
A
R
I
D
T
P
R
P
L
V
G
R
L
I
H
Q
L
L
T
D
I
G
R
Y
H
P
Q
A
L
I
Y
P
L
T
V
-------
A
S
K
S
T
T
T
A
----
R
H
N
A
A
N
K
I
L
---
K
N
M
C
E
H
S
N
T
L
V
Q
Q
A
M
M
V
S
E
E
L
-
I
R
V
A
---------------------------------------------------------------------------------------------------------------
T
S
L
E
L
Q
Y
V
S
P
K
L
L
M
C
-
R
---
D
L
E
L
A
V
P
G
T
Y
D
P
N
Q
----
P
-
I
I
R
I
Q
S
I
A
P
S
L
Q
V
I
T
-
S
K
Q
R
P
R
K
L
T
L
M
G
S
N
G
H
E
F
V
F
L
L
K
G
H
--
E
D
L
R
Q
D
E
R
V
M
Q
L
F
G
L
V
N
T
L
L
A
N
D
P
T
S
L
R
K
N
L
S
I
Q
R
Y
A
V
I
P
L
S
T
N
S
G
L
I
G
W
V
P
H
C
D
T
L
H
A
L
I
R
D
Y
R
E
K
K
K
-
I
-
L
L
N
I
E
H
R
I
M
-
L
R
M
A
P
D
Y
D
H
-----
L
T
L
M
Q
K
V
E
V
F
E
H
A
V
N
N
-
T
A
G
D
D
L
A
K
L
L
W
L
K
S
P
S
S
E
V
W
F
D
R
R
T
N
Y
T
R
S
L
A
V
M
S
M
V
G
Y
I
L
G
L
G
D
R
H
P
S
N
L
M
L
D
R
L
S
G
K
I
L
H
I
D
F
G
D
C
---
F
E
V
A
M
T
R
E
K
F
P
E
K
I
P
F
R
L
T
R
M
L
T
N
A
M
E
V
T
G
L
D
G
N
Y
R
I
T
C
H
T
V
M
E
V
L
R
E
H
K
D
S
V
M
A
V
L
E
A
F
V
Y
D
P
L
L
N
W
R
L
M
D
T
N
T
----------------------------------------------------------------------------------
A
L
----------------
N
K
K
A
I
Q
I
I
N
R
V
R
D
K
L
T
G
R
D
F
---------------------------------------------
S
H
D
D
T
L
D
V
P
T
Q
V
E
L
L
I
K
Q
A
T
S
H
E
N
L
C
Q
C
Y
I
G
W
C
P
F
W
26
HHSearch
36.10
16%
-13
- C2 -
-
5OJS
-
TRA1_YEAST
T:
[2559-3702]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
S
S
D
F
I
D
S
L
I
E
I
F
Y
Q
D
P
K
A
I
H
R
A
W
V
T
L
F
P
Q
V
Y
K
S
I
P
K
N
E
K
Y
G
F
V
R
S
I
I
T
L
L
S
K
P
YHTRQI
S
S
R
T
N
V
I
N
M
L
L
D
S
I
---
S
K
I
E
-
S
-------------
L
E
L
P
P
H
L
V
K
Y
L
A
I
S
Y
N
A
W
Y
Q
S
I
N
I
L
E
S
I
Q
S
N
T
S
I
D
N
-----------
T
K
-----
I
I
E
A
N
E
D
A
L
L
E
L
Y
V
N
L
Q
E
E
D
M
F
Y
G
L
W
R
R
R
A
K
Y
-
T
---------
E
T
--
N
I
G
L
S
Y
E
Q
I
G
L
W
D
K
A
Q
Q
L
Y
E
V
A
Q
V
K
A
R
S
G
ALPYSQSEY
A
L
W
E
D
N
W
I
Q
C
A
E
K
L
Q
H
W
D
V
L
T
----
E
L
A
K
H
E
----------
G
F
T
D
L
L
L
E
C
G
W
R
V
A
D
W
N
S
D
R
D
A
L
E
Q
S
V
KSVMD
V
P
T
P
---
R
R
Q
M
F
K
T
F
L
A
L
Q
N
F
AESRK
G
D
Q
E
V
R
K
L
C
D
E
G
I
Q
L
S
L
I
K
W
V
S
L
P
I
R
Y
T
P
A
H
K
W
L
L
H
G
F
Q
Q
Y
M
E
F
L
E
A
T
Q
I
Y
A
N
L
H-
T
TTVQNLDSKA
Q
E
---
I
K
R
---
I
L
Q
A
W
R
D
R
L
P
N
T
WD
D
--
V
N
M
W
N
D
L
V
T
W
R
Q
H
A
F
Q
V
I
NNAYLPLIPALQAYRGYH
E
I
A
W
V
I
N
R
F
A
H
V
A
R
K
H
N
M
P
D
V
C
I
S
Q
L
A
R
I
Y
T
L
P
N
I
-------
E
I
Q
E
A----
F
L
K
L
R
E
Q
A
K
C
H
Y
Q
N
M
N
E
L
T
T
G
L
D
V
I
S
N
T
N
L
V
Y
F
--------------
G
T
V
Q
------
K
A
E
F
F
T
L
K
G
M
F
L
S
K
L
R
-----------
A
Y
E
E
A
N
Q
A
F
A
T
A
V
Q
I
D
L
N
L
A
K
A
W
A
Q
W
G
F
F
N
D
R
R
L
S
E
E
P
-------------------------------
N
N
I
------
S
F
A
S
N
A
I
S
C
Y
L
Q
A
A
G
L
Y
K
NS
K
--
I
--
R
--
E
L
L
C
R
I
L
W
L
I
S
I
D
D
A
S
G
M
L
T
--
N
A
F
D
S
F
R
G
E
I
P
V
W
Y
W
I
T
F
I
P
Q
L
L
T
S
L
S
H
K
E
A
---
N
M
V
R
H
I
L
I
R
I
A
K
S
Y
P
Q
A
L
H
F
Q
L
R
T
T
K
E
D
F
A
V
I
Q
--------R
Q
P
W
E
Y
L
Q
E
L
N
N
I
---
L
K
T
A
Y
P
L
L
A
L
S
L
E
S
L
V
A
Q
I
N
D
R
F
K
S
T
T
D
E
D
L
F
R
L
I
N
V
L
L
I
D
G
TLNYNRLP
F
P
R
K
N
PK
L
P
E
N
T
E
K
N
L
V
K
F
S
--------
T
T
L
L
A
P
Y
I
R
P
K
F
N
A
D
F
I
------------
D
N
K
P
D
Y
E
T
Y
I
K
R
L
R
Y
W
R
R
R
L
E
N
K
L
D
R
A
S
K
K
E
N
L
E
V
L
C
P
H
L
S
N
-
F
H
HQK
F
E
D
I
E
I
P
G
Q
Y
L
L
N
K
DNNV
H
-
F
I
K
I
A
R
F
L
P
T
V
D
F
V
R
G
T
H
S
S
Y
R
R
L
M
I
R
G
H
D
G
S
V
H
S
F
A
V
Q
Y
P
AV
R
H
S
R
R
E
E
R
M
F
Q
L
Y
R
L
F
N
K
S
L
S
K
N
V
E
T
R
R
R
S
I
Q
F
N
L
P
I
A
I
P
L
S
P
Q
V
R
I
M
N
D
S
V
S
F
T
T
L
H
E
I
H
N
E
F
C
K
K
K
G
F
D
-
P
-
D
D
I
Q
D
F
M
A
D
K
L
N
A
A
H
D
D
ALPAP
D
M
T
I
L
K
V
E
I
F
N
S
I
Q
T
M
F
V
P
S
N
V
L
K
D
H
F
T
S
L
F
T
Q
F
E
D
F
W
L
F
R
K
Q
F
A
S
Q
Y
S
S
F
V
F
M
S
Y
M
M
M
I
N
N
R
T
P
H
K
I
H
V
D
K
T
S
G
N
V
F
T
L
E
M
L
P
S
DLS
L
P
P
D
S
P
I
F
H
N
N
E
P
V
P
F
R
L
T
P
N
I
Q
S
L
I
G
D
S
A
L
E
G
I
F
A
V
N
L
F
T
I
S
R
A
L
I
E
P
D
N
E
L
N
T
Y
L
A
L
F
I
R
D
E
I
I
S
W
-
F
S
N
L
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
36.09
39%
-
- C2 -
-
4JSN
-
MTOR_HUMAN
B:
[1880-2549]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
V
P
A
V
Q
G
F
F
R
S
I
S
L
-
S
--
R
GN
N
--
L
--
Q
D
T
L
R
V
L
T
L
W
F
D
Y
G
H
W
P
D
V
--
N
E
A
L
V
E
G
V
K
A
I
Q
I
D
T
W
L
Q
V
I
P
Q
L
I
A
R
I
D
T
P
R
P
L
V
G
R
L
I
H
Q
L
L
T
D
I
G
R
Y
H
P
Q
A
L
I
Y
P
L
T
V
-------
A
S
K
S
T
T
T
A
----
R
H
N
A
A
N
K
I
L
---
K
N
M
C
E
H
S
N
T
L
V
Q
Q
A
M
M
V
S
E
E
L
-
I
R
V
A
I
L
W
H
E
M
W
H
E
G
L
E
E
A
S
R
L
Y
--------
F
G
E
R
N
--
V
K
G
-
M
F
E
V
L
E
P
L
H
A
M
M
E
-
R
G
P
Q
T
L
K
E
T
S
F
N
Q
A
Y
G
R
D
L
M
E
A
Q
E
W
C
R
K
Y
M
K
S
G
N
V
K
D
L
T
Q
A
W
D
L
Y
Y
H
V
F
R
R
I
S
K
Q
L
P
Q
L
-
T
S
L
E
L
Q
Y
V
S
P
K
L
L
M
C
-
R
---
D
L
E
L
A
V
P
G
T
Y
D
P
N
Q
----
P
-
I
I
R
I
Q
S
I
A
P
S
L
Q
V
I
T
-
S
K
Q
R
P
R
K
L
T
L
M
G
S
N
G
H
E
F
V
F
L
L
K
G
H
--
E
D
L
R
Q
D
E
R
V
M
Q
L
F
G
L
V
N
T
L
L
A
N
D
P
T
S
L
R
K
N
L
S
I
Q
R
Y
A
V
I
P
L
S
T
N
S
G
L
I
G
W
V
P
H
C
D
T
L
H
A
L
I
R
D
Y
R
E
K
K
K
-
I
-
L
L
N
I
E
H
R
I
M
-
L
R
M
A
P
D
Y
D
H
-----
L
T
L
M
Q
K
V
E
V
F
E
H
A
V
N
N
-
T
A
G
D
D
L
A
K
L
L
W
L
K
S
P
S
S
E
V
W
F
D
R
R
T
N
Y
T
R
S
L
A
V
M
S
M
V
G
Y
I
L
G
L
G
D
R
H
P
S
N
L
M
L
D
R
L
S
G
K
I
L
H
I
D
F
G
D
C
---
F
E
V
A
M
T
R
E
K
F
P
E
K
I
P
F
R
L
T
R
M
L
T
N
A
M
E
V
T
G
L
D
G
N
Y
R
I
T
C
H
T
V
M
E
V
L
R
E
H
K
D
S
V
M
A
V
L
E
A
F
V
Y
D
P
L
L
N
W
R
L
M
D
T
N
T
----------------------------------------------------------------------------------
A
L
----------------
N
K
K
A
I
Q
I
I
N
R
V
R
D
K
L
T
G
R
D
F
---------------------------------------------
S
H
D
D
T
L
D
V
P
T
Q
V
E
L
L
I
K
Q
A
T
S
H
E
N
L
C
Q
C
Y
I
G
W
C
P
F
W
45
HHSearch
34.61
12%
-49
- C1 -
-
3W3U
-
IMB3_YEAST
A:
[60-1041]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
T
T
V
A
A
L
S
A
V
L
F
R
K
L
A
L
K
A
P
I
T
H
I
R
K
E
V
L
A
Q
I
R
S
S
L
L
K
G
F
L
S
E
R
A
D
S
I
R
H
K
---
L
S
D
A
I
A
E
C
V
Q
D
D
L
P
-
A
--------
W
P
E
L
L
Q
A
L
I
E
S
L
K
S
G
N
P
N
F
R
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S
S
F
R
I
L
T
T
V
P
Y
L
I
T
A
V
----------------
D
I
N
S
I
L
P
I
F
Q
--
S
G
F
T
D
--
A
S
D
N
V
K
I
A
A
V
T
A
F
V
G
Y
F
K
Q
L
P
K
S
-----
E
---
W
S
-----
K
LGI
L
L
P
S
L
L
N
S
L
P
R
F
L
D
D
G
-------------------
K
D
D
A
L
A
S
V
F
E
S
L
I
E
L
V
E
L
A
P
-
K
L
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K
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--
K
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L
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A
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-
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L
L
T
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-
E
N
A
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Y
G
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L
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V
T
L
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M
T
EVSIDDDDA
A
E
W
I
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SDDTDDEEE
V
T
Y
D
H
A
A
A
A
L
A
R
V
A
L
K
L
--
G
G
---
E
Y
L
A
A
P
L
F
----------------------
Q
Y
L
Q
Q
M
I
T
S
-----------------------------------------------
T
E
W
R
E
R
F
A
A
M
M
A
L
S
S
A
A
A
G
C
ADVL-
I
G
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K
I
L
D
M
V
I
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L
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N
D
P
H
P
R
V
Q
Y
G
C
C
K
V
L
G
Q
I
S
T
A
F
S
----
P
---
F
-------------
I
Q
R
T
A
H
D
R
I
L
P
A
L
I
S
K
L
T
S
E
-
C
T
S
R
V
Q
T
H
A
A
A
A
L
V
A
F
---
S
E
FAS
K
D
I
LE-
P
---
Y
L
D
S
L
L
T
N
L
L
V
L
L
Q
-
S
-
N
-
K
L
Y
V
Q
E
Q
A
L
T
T
I
A
F
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A
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A
A
K
N
K
F
I
K
Y
Y
D
T
L
M
P
L
L
L
N
V
L
K
V
N
------------------------------------
S
V
L
K
G
K
C
M
E
C
A
T
L
I
G
F
A
V
G
K
E
K
F
--
H
E
H
S
Q
E
L
I
S
I
L
V
-
A
L
Q
N
S
-
D
I
D
E
D
D
A
-
L
R
S
Y
L
E
Q
S
W
S
R
I
C
R
I
L
G
D
D
--
F
V
P
L
L
P
I
V
I
P
P
L
L
I
T
A
K
A
T
----------------
Q
D
V
GLIEEEEAANFQQYPD
W
D
V
V
Q
V
QG
K
H
I
A
I
H
T
S
V
L
D
D
K
V
S
A
M
E
L
L
Q
S
Y
A
T
L
L
R
G
-
Q
F
A
V
Y
V
--
K
E
V
M
E
E
I
A
L
P
S
L
D
F
Y
--------------
L
H
D
G
-
V
R
A
A
G
A
T
L
I
P
I
L
L
S
C
L
L
------
A
A
------------------------------
E
E
-
L
V
L
L
W
H
K
A
S
S
K
L
I
G
G
L
M
S
E
P
M
P
E
-
I
T
Q
V
Y
H
N
S
L
V
N
G
I
K
V
M
G
D
-----
N
C
L
S
E
D
Q
L
A
A
F
T
K
G
V
S
A
N
L
T
D
T
Y
E
R
M
Q
D
RDEYNEF
T
D
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D
-
L
L
D
E
I
N
K
S
I
A
A
V
L
K
T
T
N
G
H
Y
L
K
N
L
E
N
I
W
P
M
I
N
T
F
L
L
----
D
N
-
E
P
I
L
V
I
F
A
L
V
V
I
G
D
L
I
Q
Y
G
G
E
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T
A
S
M
K
N
A
F
I
P
K
V
T
E
C
L
I
-
S
P
D
A
---
R
I
---
R
Q
A
A
S
Y
I
I
G
V
C
A
Q
Y
A
P
STYA
D
V
C
I
P
T
L
D
T
L
V
Q
I
V
D
-
P
GSKL
E
E
N
R
S
S
T
E
N
A
S
A
A
I
A
K
I
L
-
Y
A
Y
-----
V
D
T
Y
T
A
N
W
F
K
T
L
P
T
I
---------------------------------
T
D
--
K
E
A
A
S
F
N
Y
Q
F
L
S
Q
L
I
E
N
N
S
----Q
S
N
I
S
A
V
V
D
-
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
Fugue
34.41
31%
-89
- C2 -
-
1NSG
1
B:
[1-94]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
I
L
W
H
E
M
W
H
E
G
L
E
E
A
S
R
L
Y
--------
F
G
E
R
N
--
V
K
G
-
M
F
E
V
L
E
P
L
H
A
M
M
E
-
R
G
P
Q
T
L
K
E
T
S
F
N
Q
A
Y
G
R
D
L
M
E
A
Q
E
W
C
R
K
Y
M
K
S
G
N
V
K
D
L
T
Q
A
W
D
L
Y
Y
H
V
F
R
R
I
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
HHSearch
33.94
11%
-45
- C1 -
-
3W3W
-
IMB3_YEAST
A:
[60-1053]
-------------------------------------------------------------------------------------------
D
T
T
V
A
A
L
S
A
V
L
F
R
K
L
A
L
K
A
P
I
T
H
--
I
R
K
E
V
L
A
Q
I
R
S
-
S
L
L
K
-
G
F
L
S
E
R
A
D
S
I
R
H
K
L
S
D
A
I
A
E
C
V
Q
D
D
L
P
-----
A
W
P
E
L
L
Q
A
--------------------------------
L
I
E
S
L
K
------------
S
G
---
N
P
N
F
R
E
S
S
F
R
I
L
T
T
V
P
Y
L
I
T
-
A
----
V
D
I
N
S
I
L
P
I
F
Q
S
G
F
T
D
A
-
S
D
N
V
K
I
A
---
A
V
T
A
F
V
G
Y
F
K
Q
L
P
K
S
E
W
S
K
L
-
G
I
L
L
P
S
L
L
N
S
L
P
R
F
L
D
D
G
K
D
D
A
L
A
S
V
F
E
S
L
I
E
L
V
E
L
A
P
K
L
F
K
------------
D
-
M
F
D
Q
I
I
Q
F
T
D
--
M
V
I
K
N
KD
L
E
P
P
A
R
T
T
A
L
E
L
L
T
V
F
S
E
N
A
P
Q
M
-----
C
K
S
N
Q
N
-----
Y
----
G
Q
T
L
V
M
V
T
L
I
M
M
T
E
V
S
IDDDDA
A
E
W
I
E
SDDTDD
E
E
E
V
T
Y
D
H
A
R
Q
A
L
D
R
V
A
L
K
L
G
G
E
Y
L
A
A
P
L
F
Q
Y
L
Q
Q
M
I
T
S
T
E
---------
W
R
E
R
F
A
A
M
-
M
A
L
S
S
A
A
-
E
G
C
A
D
V
L
---
I
G
E
I
P
K
I
L
D
M
V
I
P
L
I
NDPH
P
-------------------
R
V
Q
Y
G
C
C
N
V
L
G
Q
I
S
T
D
F
--
S
P
F
I
Q
R
T
A
H
D
R
I
L
----------------------
P
A
L
I
S
K
L
T
S
E
C
----------------------------------------------
T
S
R
V
Q
T
H
A
A
A
A
L
V
N
F
S
E
F
A
SKDIL
E
P
Y
L
D
S
L
L
T
N
L
L
V
L
L
Q
S
N
K
L
Y
V
Q
E
Q
A
L
T
T
I
A
F
I
A
E
A
A
K
----
N
-----------------
K
F
I
K
Y
Y
D
T
L
M
P
L
L
L
-
N
V
L
K
V
N--
S
V
L
K
G
K
C
M
E
C
A
T
L
I
G
F
A
V
G
---
K
-
E
---
K
F
H
E
H
S
Q
E
L
I
S
I
L
V
A
L
Q
N
S-----
D
A
L
R
S
Y
L
E
Q
S
W
S
R
I
C
R
I
L
G
D
D
F
V
P
L
L
P
I
V
I
P
P
L
L
I
T
A
K
A
T
Q
D
VGLIEEEEAANFQQYPD
W
D
V
V
Q
V
QG
K
H
I
A
I
H
T
S
V
L
D
D
K
V
S
A
M
E
L
L
Q
S
Y
A
T
L
L
R
-
G
Q
F
--
A
V
Y
V
K
E
V
M
E
E
I
A
L
P
S
L
D
F
---
Y
L
H
D
G
-
V
R
A
A
G
A
T
L
I
P
I
L
L
S
C
L
L
A
A
E
E
L
V
L
L
W
H
K
A
S
S
K
L
I
G
G
L
M
S
E
----------------
P
M
P
----------------------------------
E
I
T
Q
V
Y
H
N
S
L
V
N
G
I
K
V
M
G
D
-
N
C
L
S
E
D
Q
L
A
A
F
T
K
G
V
S
-
A
N
L
T
D
T
Y
E
R
M
Q
DRDEYNED
F
T
D
E
D
-
L
L
D
E
I
N
K
S
I
A
A
V
L
K
T
T
N
------
G
H
Y
--------------------------------
L
K
N
L
-
E
N
I
W
P
M
I
N
T
F
L
-
L
--
E
P
I
-
L
V
I
F
A
L
V
V
I
G
D
L
I
Q
Y
--
E
-----
Q
T
--
A
S
M
K
N
A
F
I
P
K
V
T
E
C
L
I
S
P--------------
D
A
R
-
I
R
Q
A
A
S
Y
I
I
G
V
C
A
Q
Y
A
P
S
T
Y
A
D
V
C
I
P
T
L
D
T
L
V
Q
I
V
D
GSKL
E
E
-
N
R
S
S
T
E
N
A
S
A
A
I
A
K
I
L
Y
A
Y
N
S
N
I
P
---
D
T
Y
T
A
N
W
F
K
T
L
P
T
I
T
D
K
---
E
A
---
A
S
F
N
Y
Q
F
L
S
Q
------VCAQ
S
N
I
S
A
V
V
D
S
V
I
Q
A
L
N
E
R
----
S
L
T
------
V
I
S
S
V
K
K
L
L
-
G
F
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
HHSearch
33.23
11%
-57
- C1 -
-
4FDD
-
TNPO1_HUMAN
A:
[26-823]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
T
T
I
Q
R
T
V
Q
Q
K
L
E
Q
L
N
Q
-
Y
P
-
D
F
N
------
N
Y
L
I
F
V
L
T
K
L
K
S
E
-
D
E
P
T
R
S
L
---
S
G
L
I
L
K
N
N
V
K
A
H
F
Q
N
F
P
N
----
G
V
T
D
F
I
K
S
E
C
L
N
N
I
G
D
S
S
P
L
I
R
A
T
V
G
I
L
I
T
T
I
A
S
K
G
E
L
Q
----------------
N
W
P
D
L
L
P
K
L
C
--
S
L
L
D
S
--
E
D
Y
N
T
C
E
G
A
F
G
A
L
Q
K
I
C
E
D
S
A
E
I
LDSDV
L
---
D
R
-----
P
----
L
N
I
M
I
P
K
F
L
Q
F
F
K
H
S
-------------------
S
P
K
I
R
S
H
A
V
A
C
V
N
Q
F
I
I
S
R
T
-
Q
A
-
L
M
L
H
I
D
S
F
I
E
N
L
F
A
L
A
-
G
D
--
E
--
E
P
E
V
R
K
N
V
C
-
R
A
L
V
M
L
L
-
E
V
R
M
D
R
L
---
L
P
H
M
H
N
I
V
E
Y
M
L
Q
R
T
Q
DQD
E
-------------------
N
V
A
L
E
A
C
E
F
W
L
T
L
A
E
Q
P
I
C
K
D
V
L
-
V
R
H
L
P
K
L
I
----------------------
P
V
L
V
N
G
M
K
Y
S
D
I
D
I
I
L
L
K
--
G
-----------------------------------
S
D
W
N
L
R
K
C
S
A
A
A
L
D
V
L
A
N
V
Y
R----
D
E
L
L
P
H
I
L
P
L
L
K
E
L
L
F
H
H
E
W
V
V
K
E
S
G
I
L
V
L
G
A
I
A
E
G
C
M
----
Q
-----------------
G
M
I
P
Y
L
P
E
L
I
P
-
H
L
I
Q
C
L
S
D
-
K
K
A
L
V
R
S
I
T
C
W
T
L
S
R
Y
---
A
H
W
V
V
S
-
Q
PPD
T
---
Y
L
K
P
L
M
T
E
L
L
K
R
I
L
-
D
-
S
-
N
K
R
V
Q
E
A
A
C
S
A
F
A
T
L
E
E
E
A
C
T
E
L
V
P
Y
L
A
Y
I
L
D
T
L
V
F
A
F
S
K
-
Y
Q
----------------------------------
H
K
N
L
L
I
L
Y
D
A
I
G
T
L
A
D
S
V
G
-
H
H
L
NK
P
E
Y
I
Q
M
L
M
P
P
L
I
-
Q
K
W
N
M
-
L
-
K
D
E
D
K
-
D
L
F
P
L
L
E
C
L
S
S
V
A
T
A
L
Q
S
G
--
F
L
P
Y
C
E
P
V
Y
Q
R
C
V
N
L
V
Q
K
T
L
A
Q
A
M
L
N
N
A
QPDQYEA
P
D
K
----------------------------------
D
F
M
I
V
A
L
D
L
L
S
G
L
A
E
G
L
G
G
-
N
I
E
Q
L
V
A
R
S
N
I
L
T
L
M
Y
-
Q
C
M
Q
D
---------------
K
M
P
E
-
V
R
Q
S
S
F
A
L
L
G
D
L
T
K
A
C
F
------
Q
H
V
K
P
---------------------------------
C
I
A
D
F
M
P
I
L
G
T
N
L
-
N
P
E
F
I
S
-
V
C
N
N
A
T
W
A
I
G
E
I
S
I
Q
M
G
I
-----
E
M
--
Q
P
Y
I
P
M
V
L
H
Q
L
V
E
I
I
N
R
PNT------------
P
K
T
-
L
L
E
N
T
A
I
T
I
G
R
L
G
Y
V
C
P
Q
E
V
A
P
M
L
Q
Q
F
I
R
P
W
C
T
S
L
R
----
N
I
R
D
N
E
E
K
D
S
A
F
R
G
I
C
T
M
I
S
V
N
P
S
G
V
I
Q
D
F
I
F
F
C
D
A
V
A
S
W
I
N
-
P
K
-
D
---
D
L
---
R
D
M
F
C
K
I
L
H
G
F
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------