@TOME V2.3
(Mar 2018)
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
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Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : TOR2: (2018-07-14 )
MSSVDSDKLATSIRALAGSRDERIAFVTEGVKQAKELQGKSVQEYEMVVSSLLMCLESFEVVHGTSLDVLCELTVLDILLNLDLSVIQLSQCNSYLRLCLMAVNEIPVAVAAAKTFAQTLSYSMTTDFVRTQIGETLEWISLSDAKSQPRRICGILVLTEVALRIPMVILPRLSEVFDRAWDCLVVHDEEVRSRALCLFTLCAKLLVNRPAAIRAETCDALMSHLKGNLASKSKGKRIAGLLAFEPIVINSIGTSNIRYEDLSNLLVPYIMGGGANVNADTRELLFRCLVVLCRFSAPQFVAHQLKESVRFALDSINRNIQRNTAFEMLSEIIPIVGKTEFAPFVDDTCEVIKTIFEKSPSPCWKALQCFSIICKECRPSKMETYVESCIENVFVWGLSAELIECMRAIIESSSVQYRAKLEESLLDMISVTLCGLPFRQQIDAPRVSESSTDVSASEYQISVALNALKQFGFSNSELMGDFLRVSVLPFIDNNSVAVRNAAVYTIVKLLIPPGEKGDLSIARRMCVNTVITRMLVVGLSDPNPVVRQTILSAFTEDFYPYLSEQQYLFRFYSALGDESINCRVAATEQLCQMIRYDPSHILPALREEMVVILHFITSTFNMDTVQNGFRLLAAIATRAPQLVVNFTEGICEALAPYFSTLSSRSGILLSFLHCCTAVAAALRKFGSTPFSSKREIALVCELLETLPADRSYHIIRLSCLRFLSATLAPLMEGASPYVLYPRLFQQLCTVLHRTEESVDIRLEALRCIGVIGALDSHVFQSFNLNEKEKASGMSAVVVDRVTHVKCCRIVLCAVAALLDPESKRSAGAREGLLRTGVQTMLNIFEHVPCSKSEIGLVIGPLARVIRQLPGGRLFATVLFEFCNIIRYGGAVVLNDLNEIYRVFDNVWEFQVNYRFLAVRMLSFVANFEASGNLHYGQQHSRILPQLFDTLNRADLRADLKYAVLEYIVRHVDSLQPCTEAAVDNLLGAIQNPANPLDFVNHCVVTLKEICVKLYVDELVGAIVRCLLACLSVDLARKTRGRDNIALCNNIMGVFCVLIEELQGNFLKYSTYIIQALKNYRITNTEFGVMNNRVATGLRCARSAMSIQQQNAEVAALLKTCESVVMKSMSRMGEVWSYANLNDDNANAGAAEERTMPINEQRLINPMKVVPLTKEEWVKWSDQFAITLLQESPFQVFRCTAVPIGINAAPLVEKSTQFVQDTLQIAFRSMWNYASSALQTAITDFFRQSFRQAMMSTTVPAEVVTMLLGIVEYMDHVGEALFISYNDLSECAWNRGMLAKALFWREAAYRDDPVGTVESLISLYSELHMVDSSVGILNMTSEEQRRSLLQTSLVKLARYTEALQLTQQELELEAAPLEESSTENLSKGCGYKNGSRGWSRMLHYTSNSDLTPSSSKAEESCRDRRVEVNARLMLCLSELGEYDKVLEQWGSMLHNYKDRVTDTDEMHVLFFVSQYAADASIRLQSWDTLEHVLDWLPPDMVLYHVSKAALEVVRGNYDAALVSVTNGRKVLLEDLTSLLHESYARAYEGLVVAQQLTEVEEVIIAKQTQKALSSAAHIPHLCHIWEQRIRMMHATVPTWKQVLGIRGLLISPHEDVKTRIQFTKLCRQEKARQLEKFTLAELLGFANPTLEQLTSRNVNPRVVMQYISYLSETNALGPGSAFGTESDLIKKMIDVHTKAENSAVLARAYTRLGSKVDLIESVQCFKTAIMYDPQWFLAWRKWAEANAQLLQTDKGEETCRNAIEGFIRSIQLGTSDSTLIQDVLKLLTLWSSHCDSDHNLKELRERVFDVPSRVWHLVVPQLVARLDTGSDDSCRLVADVLTNVGYDYPHTLVYPLNLCTMSDSERRNRYSNEVLGKLQERYPVIVLQGRLMIDELIRVSALIYEQWYDKLEAAATAFFGRRSTDEMIRTLLPIHETLTRVPETVVESEFLSKYSKRLTEARDWLRSYSSTRYTGDIQSAWKLYHSVYCNIDKQIKSSDTLQLQFCSPKLFEARNLSIGIPDARPVREESVAKVNRFQKDIIVIASKQRPKRIGIITAEGRLQKFLLKGREDLRLDERVMQLFSLVNILMQSDSRTSKNLGFQIQRYSVTPLKDNVGIIGWVDGCDTLHEVVKHFRERKSIPVELEMRMLDQIITFDNSKAYDYLTIMSKVEVLEFLSDHTSGQDIRKAMWNTSPNCEVWYDRRRMYTTSLANMSIVGYILGLGDRHPNNIMLQRASGLVVHIDFGDCFEVAMTRDKFPEKVPFRLTRMLRSALDVSGVDGAFRACSETAMCVLREGSHSVLALLEAFIQDPLISWRLINRHGQEPESSNDHKTIEQQVNIANMRNATSTAGAESMCDSVGKRDSGTFSVAKHLCGEEVDVVHQGVFIVKRLSSKLKGQDFISAGTEPLDPRTQVGQLIEEATDVTNVAQSWSGWYPFW
Atome Classification :
(20 SA)
.........10........20........30........40........50........60..-......70........80...----.....90........100.......110.......120--.......130.......140..------.....150.......160.......170.......180.......190.......200.......210-----------------------------.....-..220-------------........230........240...--....250.....-..260.......270.......280.......290..------.....300.......310.....------.-------.320.......330.......340.......350......---.---360-.......370.......380-.........390....-...400.......410.......420.......430.......-----------440.......-------450-----------------.........460.......470...-..----...480.......490.......500....-----...510.......520.......530.......540.......---550....--------...560..---.....570......-.580.......590.....-----------..600.......610......-----.620.......630.......640........650......------.660.......670.......680.....--..690.......700.......710......-.720.......730.......740.......750.......760.......770.......780.......790.......800...-....810.......---820.......--830..-..-------...840......--.850.......860......---.870.......880.......-------------890.......900.---......910.-......920.......930.......940.......950.......960.......970.......----980.......990-.......1000......1010.......1020......1030......1040......1050......1060......1070......1080......1090......1100..--....1110......1120......1130......1140.-.....1150......1160.....-.1170.......1180......1190---.....-..1200......1210......1220......1230......1240......1250...--...1260......1270...-..---------------------------.1280.......1290...----...1300......1310--.--.---.-.....1320......1330......1340.......1350.-.....1360......1370......1380......1390......1400......1410......1420......1430......1440..----....1450......1460......1470......1480......1490......-----...1500......1510.-----.....1520......1530.....--.1540......1550......1560---.......1570----........1580......1590......1600......1610-----------------.......1620......1630......1640......1650......1660......1670--------------------......-1680-........1690...----------.---.----------.1700......1710-----------..----------.....1720-------........1730......1740---.......1750-.------..-------------------..------------------..1760----------------.........1770.......1780......1790..-------------------....1800......1810......1820......1830......1840......1850......1860..---....1870......---1880......1890...-...1900......1910---...----....1920--.-.....1930......1940......1950......1960......1970......1980......1990....-..2000...-...2010---......2020....---..2030......2040.-.....2050......2060......--2070......2080......2090......2100......2110......2120......2130......2140......2150.......2160.----......2170......-2180......2190......2200......2210......2220......2230......2240....---..2250......2260......2270......2280......2290......2300......2310......---2320......2330......2340......2350.......2360......2370......2380......2390......2400........2410......2420......2430.....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MSSV
D
S
D
K
L
A
T
S
I
R
A
L
AGSRD
E
R
I
A
F
V
T
E
G
V
K
Q
A
K
E
LQGK
S
V
Q
E
Y
E
M
V
V
S
S
L
L
M
C
L
E
S
F
E
V
VH-GT
S
L
D
V
L
C
E
L
T
V
L
D
I
L
L
NL
D
L
----
S
V
I
Q
L
S
Q
C
N
S
Y
L
R
L
C
L
M
A
V
NEIP
V
A
V
A
A
A
K
T
F
A
Q
T
L
S
Y
--
S
M
T
T
D
F
V
R
T
Q
IGE
T
L
E
W
I
SLSD------AKS
Q
P
R
R
I
C
G
I
L
V
L
T
E
V
A
L
R
I
P
M
V
I
L
P
R
L
S
E
V
F
DRAW
D
C
L
V
V
H
D
E
E
V
R
S
R
A
L
C
L
F
T
L
C
A
K
L
L
VNRPA
A
-----------------------------
I
R
A
E
T
-
C
D
A
L
--------------
M
S
H
L
K
G
NLAS-KSKGK
R
I
A
G
L
L
A
F
E
--
P
I
V
I
NSIGTSNI-
R
Y
E
D
L
S
N
L
L
V
P
Y
IMGGGANVN
A
D
T
R
E
L
L
F
R
C
L
V
V
L
CR------FS
A
P
Q
F
V
A
H
Q
L
K
E
S
V
R
F
A
L
D
S
I
N------R-------NIQR
N
T
A
F
E
M
L
S
E
I
I
P
IVGKTEFA
P
F
V
D
D
T
C
E
V
I
K
T
I
F
EK---S---P
S
P
-
C
W
K
A
L
Q
C
F
S
I
I
C
K
ECR
P
S
---
K
M
E
T
Y
V
E
S
C
I
E
N
V
F
VW-GL
S
A
E
L
I
E
C
M
R
A
I
I
ESSSV
Q
Y
R
A
K
L
E
E
S
L
L
D
M
I
S
V
T
LCGL
P
F
R
-----------QQIDAPRVSE-------S-------------------STDVSAS
E
Y
Q
I
S
V
A
L
N
A
L
K
QF-GFS-
N
S
----
E
L
M
G
D
F
L
R
V
S
V
L
P
FIDNN
S
V
A
V
R
N
A
A
V
Y
T
I
-----
V
K
L
LIPPGEK
G
D
L
S
I
A
R
R
M
C
V
N
T
V
I
T
R
M
L
VVGLSDP
N
P
V
V
R
Q
T
---
I
L
S
A
F
T
E
--------
D
F
Y
P
Y
LSE---
Q
Q
Y
L
F
R
F
Y
S
A
LGDE-SI
N
C
R
V
A
A
T
E
Q
L
C
Q
M
IRY
D
-----------
P
S
H
I
L
P
A
L
R
E
E
M
V
V
I
L
H
F
I
T
S-----TFN
M
D
T
V
Q
N
G
F
R
L
L
A
A
I
A
TRA
P
Q
-
L
V
V
N
F
T
E
G
I
C
E
A
L
A
P
Y
F
------
S
T
L
SSRS
G
I
L
L
S
F
L
H
C
C
T
A
V
A
A
A
L
R
KFGS--TPFSSK
R
E
I
A
L
V
C
E
L
L
E
TLPADR
S
Y
H
I
I
R
L
S
-
C
L
R
F
L
S
A
T
L
A
P
L
MEGAS
P
Y
V
L
Y
P
R
L
F
Q
Q
L
C
T
V
L
HRTEES
V
D
I
R
L
E
A
L
R
C
I
G
V
I
G
A
L
D
S
H
V
F
Q
SFNLN
E
K
E
K
ASGM
S
A
V
V
VDRV
T
H
V
K
-
C
C
R
I
V
L
C
A
V
A
A
LLD---PESKRSAG
A
R
--
E
G
L
L
R
-
T
G
-------
V
Q
T
M
L
N
I
F
E
HVP--CSKSEI
G
L
V
I
G
P
L
A
R
V
I
R
QL---PG
G
R
L
F
A
T
V
L
F
E
F
C
N
I
I
RYG
G
-------------
A
V
V
L
N
D
L
N
E
I
Y
R
V
F
---
D
N
V
W
E
F
Q
V
N
Y
-
R
F
L
A
V
R
M
L
S
F
V
A
NFEASGNLHY
G
Q
Q
H
S
R
I
L
P
Q
L
F
D
T
L
N
R
A
D
L
R
A
D
L
K
Y
A
V
L
E
Y
I
V
R
H
V
D
SLQ
P
C
T
E
----
A
A
V
D
N
L
L
G
A
IQNP-A
N
P
L
D
F
V
N
H
C
V
V
T
L
K
E
I
C
-
V
K
L
Y
V
D
E
L
V
G
A
I
V
R
C
L
L
A
C
L
S
V
D
L
A
R
KTRGRD
N
I
A
L
C
N
N
I
M
G
V
F
C
V
L
I
E
E
LQGN
F
L
K
Y
S
T
Y
I
I
Q
A
L
K
NYRITNTEFGVMN
N
R
V
A
T
G
L
R
C
A
R
S
A
M
S
--
I
Q
Q
QN
A
E
V
A
A
L
L
K
T
C
E
S
V
V
M
K
S
M
S
R
M
G
E
V
W
S
YANLNDDN-ANAGAAEERTMPI
N
E
Q
RLINP
M
K
V-VPL-
T
K
E
E
W
V
K
WSD
Q
F
A
I
T
LLQESP----
F
Q
V
F
R
-
C
TAVPIGINA
A
P
L
V
E
K
S
T
Q
F
V
Q
D
T
L
Q
I
A
F
R
S
M
W
N
Y
A
S
S
A
L
Q
T
A
I
T
D
F
F
R
Q
S
F
R
Q
A
M
M
ST--T
V
P
A
E
V
V
T
M
L
L
G
I
V
E
Y
M
D
HV-G
E
---------------------------
A
L
-
F
I
SY
N
D
L
S
E
C
A
WNR
G
M
----
L
A
K
A
L
F
W
R
E
AAYRDD----P--
V
---
G
-
T
V
E
S
L
I
S
L
Y
S
E
L
H
M
VDSSV
G
I
L
NMT
S
E
E
-
Q
R
R
S
L
L
Q
T
S
L
V
K
-
L
A
R
Y
T
E
A
L
Q
L
T
Q
Q
E
LELEAAPLEESSTEN
L
S
KGCGYKNGSR
G
W
S
R
M
L
H
YTSNSDLTPSSS
K
A
E
E
S
C
RDR
R
V
E
V
N
A
R
L
M
L
C
L
S
E
LG
E
Y
D
K
V
L
----
E
Q
W
G
S
M
L
H
N
Y
K
DRVTDTDE
M
H
V
L
F
F
V
S
Q
YAAD
A
S
I
R
LQ
S
W
D
T
L
E
H
---
V
L
D
WLP-----
P
D
M
V
L
Y
H
V
S
K
A
A
L
E
V
V
RG-----NY
D
A
A
L
V
S
VTNGR
K
V
L
L
E
D
L
T
S
L
L
--
H
E
S
Y
A
R
A
Y
E
G
L
V
V
A
Q
Q
L
T
E
V
E
E
V
I
----
I
A
K
Q
T
Q
K
A
L
------
S
SAAH
I
P
H
L
C
H
I
W
E
Q
R
I
R
M
M
HATV
P
T
W
K
Q
V
LGIR
G
L
L
ISP
H
------------------
E
D
V
K
T
R
I
Q
F
T
K
L
C
R
Q
E
K
A
R
Q
L
E
K
F
T
L
A
E
L
LGFAN
P
T
L
E
Q
L
T
SRNV
N
P
R
V
V
M
Q
Y
I
S
Y
L
SETN--------------------ALGPGS-A--F-G
T
E
S
D
L
I
K
K
M
I
D
V
HT----------K---A----------E
N
S
A
V
L
A
R
A
Y
T
R
LG------------S
K
----------
V
D
L
I
E
S
V
---------
Q
C
F
K
T
A
IMYD
P
Q
W
F
L
A
W
R
K
W
A
----
E
AN
A
Q
L
LQTD--K------
G
E
-------------------
E
T
------------------
C
R
N
-------------------
A
I
E
G
F
I
R
S
IQL-GTS
D
S
T
L
I
Q
D
V
L
K
L
L
T
L
W
S
SHCDS-------------------DH
N
L
K
E
L
R
E
R
V
F
D
V
P
S
R
V
W
H
L
V
V
P
Q
L
V
A
R
LDTGSD
D
S
C
R
L
V
A
D
V
L
T
NVGYDYP
H
T
L
V
Y
P
L
N
L
C
TMS
D
S
E
R
---
R
N
R
Y
S
N
E
V
L
G
K
L
Q
E---RY
P
V
I
V
LQ
G
R
L
M
I
D
E
L
I
-
R
V
S
A
L
I
Y
E
Q
W
Y
D
K
L
E
A
----
A
A
T
----
A
F
FGRR
S
T
--
D
-
E
M
I
R
T
L
L
P
I
H
E
T
L
T
RV
P
E
T
V
V
E
S
E
F
L
S
K
Y
S
K
R
L
T
E
A
R
D
W
L
R
S
YSSTRYTG
D
I
Q
S
A
W
K
L
Y
H
S
V
Y
CN
I
D
K
QIKSS-D
T
L
Q
L
Q
FCS-PKLFEAR---NLSIGIPDARPV
R
E
---
E
S
V
A
K
V
N
R
FQK
D
I
I
V
I
A-SKQRP
K
R
I
G
I
I
TAE
G
R
L
Q
K
F
L
L
KGR--EDL
R
L
D
E
R
V
M
Q
L
F
S
L
V
N
I
L
M
QSDSRTSKNL
G
F
Q
I
Q
R
Y
SVTPLKDNV
G
I
I
G
WVD
G
C
D
T
L
H
E
V
V
K
H
F
R
E
RKSIP
V
E
L
E
M
R
M
L
D
Q
-
I
I
TFDNSKA
Y
-
D
Y
----
L
T
I
M
S
K
V
E
V
L
E
F
L
S
DH-TS
G
Q
D
I
R
K
A
MWNTSPNC
E
V
W
Y
DR
R
R
M
Y
T
TSLAN
M
S
I
V
G
Y
I
L
GLGDRHPN
N
I
M
L
Q
RAS
G
L
V
V
H
IDFG
D
C
---
F
E
V
A
M
T
RDKFPEKV
P
F
R
L
T
R
M
L
R
S
ALDVSGV
D
G
A
F
R
A
C
S
E
T
A
M
C
V
LREG
S
H
S
V
L
A
L
L
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A
F
I
QDP
L
I
S
W
R
L
I
N
---RHGQEPESSND
H
K
T
I
E
Q
Q
V
N
I
A
NMRNATSTA
G
-
A
E
S
M
C
D
S
VGKRDS
G
T
F
S
V
A
K
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L
CG
E
E
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D
V
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Q
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P
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T
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V
G
Q
L
I
E
E
A
T
D
V
T
N
V
A
Q
SWSGWYPFW
62
Fugue
59.73
26%
-13
- C2 -
-
5FVM
-
?
A:
[85-2469]
---------
N
V
K
A
F
D
L
I
F
T
K
L
N
Q
L
E
R
V
A
A
S
Y
E
L
K
S
C
L
I
S
L
V
S
T
E
Y
F
Q
R
F
S
N
D
I
N
-
N
K
V
F
E
L
I
H
-
D
-
S
N
E
K
L
G
G
V
L
A
V
D
T
L
I
D
----------
E
L
P
N
Q
T
S
R
L
A
N
Y
L
R
V
L
I
D
I
E
V
M
R
A
A
A
T
T
L
G
K
L
--
A
--
V
L
T
S
E
F
V
E
F
E
V
K
T
C
I
E
W
L
T
Q
E
Y
------
R
K
H
A
S
L
L
I
I
S
S
Y
--------------
P
F
V
N
S
I
L
D
N
I
W
R
A
L
------------------------
R
K
L
V
-----------------------------
I
R
T
D
A
-
A
V
T
L
--------------
G
K
C
L
T
S
S
L
T
K
-
K
W
V
Q
R
L
F
N
G
C
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H
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--
L
L
V
Y
R
Q
L
V
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L
E
L
-
K
----
D
K
Y
E
E
I
Y
E
T
T
M
K
H
R
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N
I
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K
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A
I
I
P
V
L
A
--------
A
D
P
K
L
F
T
Q
K
Y
L
D
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M
I
H
Y
L
T
L
L
------
L
-------
S
D
K
G
P
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V
S
I
G
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--
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L
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---
R
---
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---
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-------
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A
R
A
Y
R
D
-------
Q
-------------------
S
L
L
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K
T
G
T
L
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A
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R
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L
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-
P
K
----
Y
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L
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I
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R
V
I
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Y
M
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H
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V
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L
A
A
L
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S
-----
C
D
L
F
V
K
-------
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---
I
L
K
H
L
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-------------
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Q
---
P
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L
L
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L
-----------------
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L
L
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H
-----
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------------------------
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--
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----------------------
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---
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---
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L
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L
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-------------
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---
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--------------
L
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-------
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-
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------------------------------
N
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L
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N
N
A
----------------
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---
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---
A
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K
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----
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---------------------
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A
A
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-----------
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-
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K
---------------------------
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L
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A
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N
K
R
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A
-------------------------------------------------------
E
V
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G
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L
H
A
L
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W
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----
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----------
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---
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I
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K
-----
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-----
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L
L
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V
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----
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Y
K
K
L
P
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---------
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R
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L
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P
K
------------------
Q
D
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--------------------
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-
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---
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----------
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----------
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A
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------------
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L
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--
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------
D
D
-------------------
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N
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Q
R
H
V
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-------------------
A
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L
-
S
Q
S
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---
L
Q
D
T
L
R
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W
F
K
F
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G
I
-------------------
P
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---
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---
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---
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----
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---
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L
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A
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D
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L
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N
W
G
F
D
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---
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A
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N
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L
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V
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D
-
A
A
K
M
----------------
E
L
Q
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--
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--
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L
C
Q
H
Y
I
G
W
C
S
--
61
Fugue
59.32
28%
-6
- C2 -
-
5H64
-
MTOR_HUMAN
A:
[210-2549]
------------------
V
A
A
L
R
A
C
L
I
L
T
T
Q
R
E
P
K
E
M
Q
K
P
Q
W
Y
R
H
T
F
E
E
A
E
-------------------------------------------------------------------
K
G
F
D
E
T
L
A
K
--
E
K
--------------------------
G
M
N
R
D
D
R
I
H
G
A
L
L
I
L
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L
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E
M
E
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T
Q
Q
Q
L
V
H
D
K
Y
C
K
D
L
M
G
---------
F
G
T
K
P
R
H
-----------------------------
I
T
P
F
T
S
F
Q
A
V
--------------
Q
P
Q
Q
S
N
A
L
V
G
-
L
L
G
Y
S
S
H
Q
G
L
M
G
F
----------
G
T
S
-------------
P
S
P
A
K
S
T
L
V
E
S
R
C
C
R
D
L
M
E
E
K
F
D
Q
V
C
Q
------
W
--------------
V
L
K
C
R
N
S
K
------
N
-------
S
L
I
Q
M
T
I
L
N
L
L
P
R
L
A
A
F
-------------------------------------------------
R
P
S
---
A
F
T
D
T
Q
Y
L
Q
D
T
M
N
H
V
L
-
S
C
V
K
V
L
Y
D
L
S
R
Q
I
P
Q
L
-----
K
K
D
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G
L
L
K
M
L
S
L
V
L
M
H
K
P
L
R
-----------
H
P
G
M
P
K
G
L
A
H
Q
L
A
S
PGL
T
-------------------
T
L
P
E
A
S
D
V
G
S
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L
A
L
R
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L
G
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F
-
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F
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----
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L
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V
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D
P
D
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C
---
V
L
A
S
L
D
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--------
R
F
D
A
H
L
A
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---
A
E
N
L
Q
A
L
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A
L
N
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Q
-
V
F
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L
A
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G
R
L
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S
M
N
-----------
P
A
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P
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L
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M
L
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I
L
T
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L
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H
-----
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--
E
L
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----------
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I
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M
L
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L
L
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-
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L
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L
L
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M
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A
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R
--
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Q
-
S
L
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V
Q
A
I
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F
I
F
K
S
L
G
--
L
K
C
V
Q
F
L
P
Q
V
M
P
T
F
L
N
V
I
R
V
---
C
D
G
A
I
R
E
F
L
F
Q
Q
L
G
M
L
V
S
F
V
K
-------------
S
H
I
R
P
Y
M
D
E
I
V
T
L
M
---
R
E
F
W
V
M
N
T
S
I
Q
S
T
I
I
L
L
I
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I
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L
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L
L
A
A
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Q
L
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N
L
D
D
Y
L
H
L
L
L
----
P
P
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V
K
L
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A
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A
P
-
L
P
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A
A
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P
I
V
R
T
L
D
Q
--------------
S
P
E
L
R
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A
M
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T
L
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S
L
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K
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-
L
M
K
K
L
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--
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S
T
I
N
L
Q
K
A
--------------------
W
G
A
A
R
--------------------------------
R
V
-
S
K
D
D
W
L
E
W
L
R
R
L
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L
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L
L
K
D
S
S
-------------
S
P
S
L
R
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C
W
A
L
A
Q
A
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N
P
M
A
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D
L
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A
A
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C
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----
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E
L
N
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D
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Q
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L
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L
A
L
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A
-
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V
T
Q
T
L
L
N
L
A
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F
M
E
H
S
D
K
G
---------------------------
P
L
-
P
L
R
D
D
N
G
I
V
L
L
G
E
R
A
A
KCRA
Y
A
K
A
L
H
Y
K
E
L
E
F
Q
K
G
----
P
T
-
P
---
A
-
I
L
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S
L
I
S
I
N
N
K
L
Q
Q
P
E
A
A
A
G
V
L
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Y
A
M
K
H
-
F
----------------------------------------------
G
E
L
E
I
Q
A
T
W
Y
E
K
L
H
--
E
W
E
D
A
L
V
A
Y
D
K
K
M
D
T
N
K
D
D
P
E
L
M
L
G
R
-
M
R
C
L
E
A
L
G
E
-----------
W
G
Q
L
H
Q
Q
C
C
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K
W
T
L
V
N
D
E
T
Q
A
K
M
A
-
R
M
A
A
A
A
A
W
G
L
G
Q
W
D
S
M
E
E
---
Y
T
C
M
I
P
-----
R
D
T
H
D
G
A
F
Y
R
A
V
L
A
L
H
Q
D
-----
L
F
S
L
A
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Q
C
I
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K
A
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L
L
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A
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L
T
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A
--
G
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S
Y
S
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A
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G
A
M
V
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C
H
M
L
S
E
L
E
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V
I
----
Q
Y
K
L
V
P
E
------------
R
R
E
I
I
R
Q
I
W
W
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R
L
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G
C
Q
R
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D
W
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I
L
M
V
R
S
L
V
V
S
P
H
------------------
E
D
M
R
T
W
L
K
Y
A
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L
C
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S
G
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L
A
L
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L
L
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L
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A
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M
K
N
M
W
K
S
A
----------------------
R
K
I
D
-
A
--
F
-
Q
H
M
Q
H
F
V
Q
T
M
Q
Q
Q
A
Q
----------
H
---
A
IATEDQQHKQ
E
L
H
K
L
M
A
R
C
F
L
K
L
G
------------
E
W
----------
Q
L
N
L
Q
G
I
N
E
S
T
I
P
K
V
L
Q
Y
Y
S
A
A
T
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H
D
R
S
W
Y
K
A
W
H
A
W
A
----
V
M
N
F
E
A
V
L
H
Y
--
K
------
H
Q
N
Q
A
R
DEKKK
V
T
E
D
L
S
K
T
L
L
M
Y
------------------
T
V
P
-------------------
A
V
Q
G
F
F
R
S
I
S
L
-
S
R
G
N
N
--
L
Q
D
T
L
R
V
L
T
L
W
F
D
Y
G
H
W
-------------------
P
D
V
N
E
A
L
V
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G
V
K
A
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Q
I
D
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W
L
Q
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L
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R
L
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L
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A
L
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P
L
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A
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K
S
T
T
T
A
---
R
H
N
A
A
N
K
I
L
K
N
M
C
E
---
H
S
N
T
L
V
Q
Q
A
M
M
V
S
E
E
L
I
-
R
V
A
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L
W
H
E
M
W
H
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G
L
E
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----
A
S
R
----
L
Y
F
G
E
R
N
V
--
K
-
G
M
F
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V
L
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L
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A
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M
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Q
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L
K
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A
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V
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D
L
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A
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L
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R
R
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K
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L
P
Q
L
-
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S
L
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L
Q
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V
S
-
P
K
L
L
M
C
R
---
D
L
E
L
A
V
P
G
T
Y
D
-
P
N
---
Q
P
I
I
R
I
Q
S
I
A
P
S
L
Q
V
I
T
-
S
K
Q
R
P
R
K
L
T
L
M
G
S
N
G
H
E
F
V
F
L
L
K
G
H
--
E
D
L
R
Q
D
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R
V
M
Q
L
F
G
L
V
N
T
L
L
A
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D
-
P
T
S
L
R
K
N
L
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A
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L
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G
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D
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L
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A
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D
Y
R
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K
K
K
I
L
L
N
I
E
H
R
I
M
L
R
-
M
-----
A
P
D
Y
-
D
H
----
L
T
L
M
Q
K
V
E
V
F
E
H
A
V
N
N
-
T
A
G
D
D
L
A
K
L
L
W
L
K
S
P
S
S
E
V
W
F
D
R
R
T
N
Y
T
R
S
L
A
V
M
S
M
V
G
Y
I
L
G
L
G
D
R
H
P
S
N
L
M
L
D
R
L
S
G
K
I
L
H
I
D
F
G
D
C
---
F
E
V
A
M
T
R
E
K
F
P
E
K
I
P
F
R
L
T
R
M
L
T
N
A
M
E
V
T
G
L
D
G
N
Y
R
I
T
C
H
T
V
M
E
V
L
R
E
H
K
D
S
V
M
A
V
L
E
A
F
V
Y
D
P
L
L
N
W
R
L
M
D
---
T
N
T
A
---------------------------------------------------------
L
N
K
K
A
I
Q
I
I
N
R
V
R
D
K
L
T
G
R
D
F
----
S
H
D
D
T
L
D
V
P
T
Q
V
E
L
L
I
K
Q
A
T
S
H
E
N
L
C
Q
C
Y
I
G
W
C
P
F
W
10
PsiBlast_PDB
58.08
40%
-114
- C2 -
-
5WBU
-
B:
[512-1177]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
Q
G
F
F
R
S
I
S
L
-
S
R
G
N
N
--
L
Q
D
T
L
R
V
L
T
L
W
F
D
Y
G
H
W
-------------------
P
D
V
N
E
A
L
V
E
G
V
K
A
I
Q
I
D
T
W
L
Q
V
I
P
Q
L
I
A
R
I
D
T
P
R
P
L
V
G
R
L
I
H
Q
L
L
T
D
I
G
R
Y
H
P
Q
A
L
I
Y
P
L
T
V
A
S
K
S
T
T
T
A
---
R
H
N
A
A
N
K
I
L
K
N
M
C
E
---
H
S
N
T
L
V
Q
Q
A
M
M
V
S
E
E
L
I
-
R
V
A
I
L
W
H
E
M
W
H
E
G
L
E
E
----
A
S
R
----
L
Y
F
G
E
R
N
V
--
K
-
G
M
F
E
V
L
E
P
L
H
A
M
M
E
R
G
P
Q
T
L
K
E
T
S
F
N
Q
A
Y
G
R
D
L
M
E
A
Q
E
W
C
R
K
Y
M
K
S
G
N
V
K
D
L
T
Q
A
W
D
L
Y
Y
H
V
F
R
R
I
S
K
Q
L
P
Q
L
-
T
S
L
E
L
Q
Y
V
S
-
P
K
L
L
M
C
R
---
D
L
E
L
A
V
P
G
T
Y
D
P
-
N
---
Q
P
I
I
R
I
Q
S
I
A
P
S
L
Q
V
I
T
-
S
K
Q
R
P
R
K
L
T
L
M
G
S
N
G
H
E
F
V
F
L
L
K
G
H
--
E
D
L
R
Q
D
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R
V
M
Q
L
F
G
L
V
N
T
L
L
A
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D
P
-
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S
L
R
K
N
L
S
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Y
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L
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T
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S
G
L
I
G
W
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H
C
D
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L
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A
L
I
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D
Y
R
E
K
K
K
I
L
L
N
I
E
H
R
I
M
L
R
-
M
-----
A
P
D
Y
-
D
H
----
L
T
L
M
Q
K
V
E
V
F
E
H
A
V
N
N
-
T
A
G
D
D
L
A
K
L
L
W
L
K
S
P
S
S
E
V
W
F
D
R
R
T
N
Y
T
R
S
L
A
V
M
S
M
V
G
Y
I
L
G
L
G
D
R
H
P
S
N
L
M
L
D
R
L
S
G
K
I
L
H
I
D
F
G
D
C
---
F
E
V
A
M
T
R
E
K
F
P
E
K
I
P
F
R
L
T
R
M
L
T
N
A
M
E
V
T
G
L
D
G
N
Y
R
I
T
C
H
T
V
M
E
V
L
R
E
H
K
D
S
V
M
A
V
L
E
A
F
V
Y
D
P
L
L
N
W
R
L
M
D
TNT-------------------------------------------------
A
L
N
K
-----------
K
A
I
Q
I
I
N
R
V
R
D
K
L
T
G
R
D
F
S
--
H
D
D
T
--
L
D
V
P
T
Q
V
E
L
L
I
K
Q
A
T
S
H
E
N
L
C
Q
C
Y
I
G
W
C
P
F
W
11
PsiBlast_PDB
57.71
40%
-114
- C2 -
-
5WBY
-
B:
[512-1177]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
Q
G
F
F
R
S
I
S
L
-
S
R
G
N
N
--
L
Q
D
T
L
R
V
L
T
L
W
F
D
Y
G
H
W
-------------------
P
D
V
N
E
A
L
V
E
G
V
K
A
I
Q
I
D
T
W
L
Q
V
I
P
Q
L
I
A
R
I
D
T
P
R
P
L
V
G
R
L
I
H
Q
L
L
T
D
I
G
R
Y
H
P
Q
A
L
I
Y
P
L
T
V
A
S
K
S
T
T
T
A
---
R
H
N
A
A
N
K
I
L
K
N
M
C
E
---
H
S
N
T
L
V
Q
Q
A
M
M
V
S
E
E
L
I
-
R
V
A
I
L
W
H
E
M
W
H
E
G
L
E
E
----
A
S
R
----
L
Y
F
G
E
R
N
V
--
K
-
G
M
F
E
V
L
E
P
L
H
A
M
M
E
R
G
P
Q
T
L
K
E
T
S
F
N
Q
A
Y
G
R
D
L
M
E
A
Q
E
W
C
R
K
Y
M
K
S
G
N
V
K
D
L
T
Q
A
W
D
L
Y
Y
H
V
F
R
R
I
S
K
Q
L
P
Q
L
-
T
S
L
E
L
Q
Y
V
S
-
P
K
L
L
M
C
R
---
D
L
E
L
A
V
P
G
T
Y
D
P
-
N
---
Q
P
I
I
R
I
Q
S
I
A
P
S
L
Q
V
I
T
-
S
K
Q
R
P
R
K
L
T
L
M
G
S
N
G
H
E
F
V
F
L
L
K
G
H
--
E
D
L
R
Q
D
E
R
V
M
Q
L
F
G
L
V
N
T
L
L
A
N
D
P
-
T
S
L
R
K
N
L
S
I
Q
R
Y
A
V
I
P
L
S
T
N
S
G
L
I
G
W
V
P
H
C
D
T
L
H
A
L
I
R
D
Y
R
E
K
K
K
I
L
L
N
I
E
H
R
I
M
L
R
-
M
-----
A
P
D
Y
-
D
H
----
L
T
L
M
Q
K
V
E
V
F
E
H
A
V
N
N
-
T
A
G
D
D
L
A
K
L
L
W
L
K
S
P
S
S
E
V
W
F
D
R
R
T
N
Y
T
R
S
L
A
V
M
S
M
V
G
Y
I
L
G
L
G
D
R
H
P
S
N
L
M
L
D
R
L
S
G
K
I
L
H
I
D
F
G
D
C
---
F
E
V
A
M
T
R
E
K
F
P
E
K
I
P
F
R
L
T
R
M
L
T
N
A
M
E
V
T
G
L
D
G
N
Y
R
I
T
C
H
T
V
M
E
V
L
R
E
H
K
D
S
V
M
A
V
L
E
A
F
V
Y
D
P
L
L
N
W
R
L
M
D
TNT-------------------------------------------------
A
L
N
K
-----------
K
A
I
Q
I
I
N
R
V
R
D
K
L
T
G
R
D
F
S
--
H
D
D
T
--
L
D
V
P
T
Q
V
E
L
L
I
K
Q
A
T
S
H
E
N
L
C
Q
C
Y
I
G
W
C
P
F
W
3
PsiBlast_PDB
57.07
40%
-112
- C2 -
-
4JSP
1
B:
[509-1174]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
Q
G
F
F
R
S
I
S
L
-
S
R
G
N
N
--
L
Q
D
T
L
R
V
L
T
L
W
F
D
Y
G
H
W
-------------------
P
D
V
N
E
A
L
V
E
G
V
K
A
I
Q
I
D
T
W
L
Q
V
I
P
Q
L
I
A
R
I
D
T
P
R
P
L
V
G
R
L
I
H
Q
L
L
T
D
I
G
R
Y
H
P
Q
A
L
I
Y
P
L
T
V
A
S
K
S
T
T
T
A
---
R
H
N
A
A
N
K
I
L
K
N
M
C
E
---
H
S
N
T
L
V
Q
Q
A
M
M
V
S
E
E
L
I
-
R
V
A
I
L
W
H
E
M
W
H
E
G
L
E
E
----
A
S
R
----
L
Y
F
G
E
R
N
V
--
K
-
G
M
F
E
V
L
E
P
L
H
A
M
M
E
R
G
P
Q
T
L
K
E
T
S
F
N
Q
A
Y
G
R
D
L
M
E
A
Q
E
W
C
R
K
Y
M
K
S
G
N
V
K
D
L
T
Q
A
W
D
L
Y
Y
H
V
F
R
R
I
S
K
Q
L
P
Q
L
-
T
S
L
E
L
Q
Y
V
S
-
P
K
L
L
M
C
R
---
D
L
E
L
A
V
P
G
T
Y
D
P
-
N
---
Q
P
I
I
R
I
Q
S
I
A
P
S
L
Q
V
I
T
-
S
K
Q
R
P
R
K
L
T
L
M
G
S
N
G
H
E
F
V
F
L
L
K
G
H
--
E
D
L
R
Q
D
E
R
V
M
Q
L
F
G
L
V
N
T
L
L
A
N
D
P
-
T
S
L
R
K
N
L
S
I
Q
R
Y
A
V
I
P
L
S
T
N
S
G
L
I
G
W
V
P
H
C
D
T
L
H
A
L
I
R
D
Y
R
E
K
K
K
I
L
L
N
I
E
H
R
I
M
L
R
-
M
-----
A
P
D
Y
-
D
H
----
L
T
L
M
Q
K
V
E
V
F
E
H
A
V
N
N
-
T
A
G
D
D
L
A
K
L
L
W
L
K
S
P
S
S
E
V
W
F
D
R
R
T
N
Y
T
R
S
L
A
V
M
S
M
V
G
Y
I
L
G
L
G
D
R
H
P
S
N
L
M
L
D
R
L
S
G
K
I
L
H
I
D
F
G
D
C
---
F
E
V
A
M
T
R
E
K
F
P
E
K
I
P
F
R
L
T
R
M
L
T
N
A
M
E
V
T
G
L
D
G
N
Y
R
I
T
C
H
T
V
M
E
V
L
R
E
H
K
D
S
V
M
A
V
L
E
A
F
V
Y
D
P
L
L
N
W
R
L
M
D
TNT-------------------------------------------------
A
L
N
K
-----------
K
A
I
Q
I
I
N
R
V
R
D
K
L
T
G
R
D
F
S
--
H
D
D
T
--
L
D
V
P
T
Q
V
E
L
L
I
K
Q
A
T
S
H
E
N
L
C
Q
C
Y
I
G
W
C
P
F
W
7
PsiBlast_PDB
56.85
40%
-114
- C2 -
-
4JT5
1
B:
[509-1174]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
Q
G
F
F
R
S
I
S
L
-
S
R
G
N
N
--
L
Q
D
T
L
R
V
L
T
L
W
F
D
Y
G
H
W
-------------------
P
D
V
N
E
A
L
V
E
G
V
K
A
I
Q
I
D
T
W
L
Q
V
I
P
Q
L
I
A
R
I
D
T
P
R
P
L
V
G
R
L
I
H
Q
L
L
T
D
I
G
R
Y
H
P
Q
A
L
I
Y
P
L
T
V
A
S
K
S
T
T
T
A
---
R
H
N
A
A
N
K
I
L
K
N
M
C
E
---
H
S
N
T
L
V
Q
Q
A
M
M
V
S
E
E
L
I
-
R
V
A
I
L
W
H
E
M
W
H
E
G
L
E
E
----
A
S
R
----
L
Y
F
G
E
R
N
V
--
K
-
G
M
F
E
V
L
E
P
L
H
A
M
M
E
R
G
P
Q
T
L
K
E
T
S
F
N
Q
A
Y
G
R
D
L
M
E
A
Q
E
W
C
R
K
Y
M
K
S
G
N
V
K
D
L
T
Q
A
W
D
L
Y
Y
H
V
F
R
R
I
S
K
Q
L
P
Q
L
-
T
S
L
E
L
Q
Y
V
S
-
P
K
L
L
M
C
R
---
D
L
E
L
A
V
P
G
T
Y
D
P
-
N
---
Q
P
I
I
R
I
Q
S
I
A
P
S
L
Q
V
I
T
-
S
K
Q
R
P
R
K
L
T
L
M
G
S
N
G
H
E
F
V
F
L
L
K
G
H
--
E
D
L
R
Q
D
E
R
V
M
Q
L
F
G
L
V
N
T
L
L
A
N
D
P
-
T
S
L
R
K
N
L
S
I
Q
R
Y
A
V
I
P
L
S
T
N
S
G
L
I
G
W
V
P
H
C
D
T
L
H
A
L
I
R
D
Y
R
E
K
K
K
I
L
L
N
I
E
H
R
I
M
L
R
-
M
-----
A
P
D
Y
-
D
H
----
L
T
L
M
Q
K
V
E
V
F
E
H
A
V
N
N
-
T
A
G
D
D
L
A
K
L
L
W
L
K
S
P
S
S
E
V
W
F
D
R
R
T
N
Y
T
R
S
L
A
V
M
S
M
V
G
Y
I
L
G
L
G
D
R
H
P
S
N
L
M
L
D
R
L
S
G
K
I
L
H
I
D
F
G
D
C
---
F
E
V
A
M
T
R
E
K
F
P
E
K
I
P
F
R
L
T
R
M
L
T
N
A
M
E
V
T
G
L
D
G
N
Y
R
I
T
C
H
T
V
M
E
V
L
R
E
H
K
D
S
V
M
A
V
L
E
A
F
V
Y
D
P
L
L
N
W
R
L
M
D
TNT-------------------------------------------------
A
L
N
K
-----------
K
A
I
Q
I
I
N
R
V
R
D
K
L
T
G
R
D
F
S
--
H
D
D
T
--
L
D
V
P
T
Q
V
E
L
L
I
K
Q
A
T
S
H
E
N
L
C
Q
C
Y
I
G
W
C
P
F
W
6
PsiBlast_PDB
56.82
40%
-110
- C2 -
-
4JSX
1
B:
[509-1174]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
Q
G
F
F
R
S
I
S
L
-
S
R
G
N
N
--
L
Q
D
T
L
R
V
L
T
L
W
F
D
Y
G
H
W
-------------------
P
D
V
N
E
A
L
V
E
G
V
K
A
I
Q
I
D
T
W
L
Q
V
I
P
Q
L
I
A
R
I
D
T
P
R
P
L
V
G
R
L
I
H
Q
L
L
T
D
I
G
R
Y
H
P
Q
A
L
I
Y
P
L
T
V
A
S
K
S
T
T
T
A
---
R
H
N
A
A
N
K
I
L
K
N
M
C
E
---
H
S
N
T
L
V
Q
Q
A
M
M
V
S
E
E
L
I
-
R
V
A
I
L
W
H
E
M
W
H
E
G
L
E
E
----
A
S
R
----
L
Y
F
G
E
R
N
V
--
K
-
G
M
F
E
V
L
E
P
L
H
A
M
M
E
R
G
P
Q
T
L
K
E
T
S
F
N
Q
A
Y
G
R
D
L
M
E
A
Q
E
W
C
R
K
Y
M
K
S
G
N
V
K
D
L
T
Q
A
W
D
L
Y
Y
H
V
F
R
R
I
S
K
Q
L
P
Q
L
-
T
S
L
E
L
Q
Y
V
S
-
P
K
L
L
M
C
R
---
D
L
E
L
A
V
P
G
T
Y
D
P
-
N
---
Q
P
I
I
R
I
Q
S
I
A
P
S
L
Q
V
I
T
-
S
K
Q
R
P
R
K
L
T
L
M
G
S
N
G
H
E
F
V
F
L
L
K
G
H
--
E
D
L
R
Q
D
E
R
V
M
Q
L
F
G
L
V
N
T
L
L
A
N
D
P
-
T
S
L
R
K
N
L
S
I
Q
R
Y
A
V
I
P
L
S
T
N
S
G
L
I
G
W
V
P
H
C
D
T
L
H
A
L
I
R
D
Y
R
E
K
K
K
I
L
L
N
I
E
H
R
I
M
L
R
-
M
-----
A
P
D
Y
-
D
H
----
L
T
L
M
Q
K
V
E
V
F
E
H
A
V
N
N
-
T
A
G
D
D
L
A
K
L
L
W
L
K
S
P
S
S
E
V
W
F
D
R
R
T
N
Y
T
R
S
L
A
V
M
S
M
V
G
Y
I
L
G
L
G
D
R
H
P
S
N
L
M
L
D
R
L
S
G
K
I
L
H
I
D
F
G
D
C
---
F
E
V
A
M
T
R
E
K
F
P
E
K
I
P
F
R
L
T
R
M
L
T
N
A
M
E
V
T
G
L
D
G
N
Y
R
I
T
C
H
T
V
M
E
V
L
R
E
H
K
D
S
V
M
A
V
L
E
A
F
V
Y
D
P
L
L
N
W
R
L
M
D
TNT-------------------------------------------------
A
L
N
K
-----------
K
A
I
Q
I
I
N
R
V
R
D
K
L
T
G
R
D
F
S
--
H
D
D
T
--
L
D
V
P
T
Q
V
E
L
L
I
K
Q
A
T
S
H
E
N
L
C
Q
C
Y
I
G
W
C
P
F
W
4
PsiBlast_PDB
56.53
40%
-111
- C2 -
-
4JSV
2
B:
[509-1174]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
Q
G
F
F
R
S
I
S
L
-
S
R
G
N
N
--
L
Q
D
T
L
R
V
L
T
L
W
F
D
Y
G
H
W
-------------------
P
D
V
N
E
A
L
V
E
G
V
K
A
I
Q
I
D
T
W
L
Q
V
I
P
Q
L
I
A
R
I
D
T
P
R
P
L
V
G
R
L
I
H
Q
L
L
T
D
I
G
R
Y
H
P
Q
A
L
I
Y
P
L
T
V
A
S
K
S
T
T
T
A
---
R
H
N
A
A
N
K
I
L
K
N
M
C
E
---
H
S
N
T
L
V
Q
Q
A
M
M
V
S
E
E
L
I
-
R
V
A
I
L
W
H
E
M
W
H
E
G
L
E
E
----
A
S
R
----
L
Y
F
G
E
R
N
V
--
K
-
G
M
F
E
V
L
E
P
L
H
A
M
M
E
R
G
P
Q
T
L
K
E
T
S
F
N
Q
A
Y
G
R
D
L
M
E
A
Q
E
W
C
R
K
Y
M
K
S
G
N
V
K
D
L
T
Q
A
W
D
L
Y
Y
H
V
F
R
R
I
S
K
Q
L
P
Q
L
-
T
S
L
E
L
Q
Y
V
S
-
P
K
L
L
M
C
R
---
D
L
E
L
A
V
P
G
T
Y
D
P
-
N
---
Q
P
I
I
R
I
Q
S
I
A
P
S
L
Q
V
I
T
-
S
K
Q
R
P
R
K
L
T
L
M
G
S
N
G
H
E
F
V
F
L
L
K
G
H
--
E
D
L
R
Q
D
E
R
V
M
Q
L
F
G
L
V
N
T
L
L
A
N
D
P
-
T
S
L
R
K
N
L
S
I
Q
R
Y
A
V
I
P
L
S
T
N
S
G
L
I
G
W
V
P
H
C
D
T
L
H
A
L
I
R
D
Y
R
E
K
K
K
I
L
L
N
I
E
H
R
I
M
L
R
-
M
-----
A
P
D
Y
-
D
H
----
L
T
L
M
Q
K
V
E
V
F
E
H
A
V
N
N
-
T
A
G
D
D
L
A
K
L
L
W
L
K
S
P
S
S
E
V
W
F
D
R
R
T
N
Y
T
R
S
L
A
V
M
S
M
V
G
Y
I
L
G
L
G
D
R
H
P
S
N
L
M
L
D
R
L
S
G
K
I
L
H
I
D
F
G
D
C
---
F
E
V
A
M
T
R
E
K
F
P
E
K
I
P
F
R
L
T
R
M
L
T
N
A
M
E
V
T
G
L
D
G
N
Y
R
I
T
C
H
T
V
M
E
V
L
R
E
H
K
D
S
V
M
A
V
L
E
A
F
V
Y
D
P
L
L
N
W
R
L
M
D
TNT-------------------------------------------------
A
L
N
K
-----------
K
A
I
Q
I
I
N
R
V
R
D
K
L
T
G
R
D
F
S
--
H
D
D
T
--
L
D
V
P
T
Q
V
E
L
L
I
K
Q
A
T
S
H
E
N
L
C
Q
C
Y
I
G
W
C
P
F
W
8
PsiBlast_PDB
56.47
40%
-112
- C2 -
-
4JT6
1
B:
[509-1174]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
Q
G
F
F
R
S
I
S
L
-
S
R
G
N
N
--
L
Q
D
T
L
R
V
L
T
L
W
F
D
Y
G
H
W
-------------------
P
D
V
N
E
A
L
V
E
G
V
K
A
I
Q
I
D
T
W
L
Q
V
I
P
Q
L
I
A
R
I
D
T
P
R
P
L
V
G
R
L
I
H
Q
L
L
T
D
I
G
R
Y
H
P
Q
A
L
I
Y
P
L
T
V
A
S
K
S
T
T
T
A
---
R
H
N
A
A
N
K
I
L
K
N
M
C
E
---
H
S
N
T
L
V
Q
Q
A
M
M
V
S
E
E
L
I
-
R
V
A
I
L
W
H
E
M
W
H
E
G
L
E
E
----
A
S
R
----
L
Y
F
G
E
R
N
V
--
K
-
G
M
F
E
V
L
E
P
L
H
A
M
M
E
R
G
P
Q
T
L
K
E
T
S
F
N
Q
A
Y
G
R
D
L
M
E
A
Q
E
W
C
R
K
Y
M
K
S
G
N
V
K
D
L
T
Q
A
W
D
L
Y
Y
H
V
F
R
R
I
S
K
Q
L
P
Q
L
-
T
S
L
E
L
Q
Y
V
S
-
P
K
L
L
M
C
R
---
D
L
E
L
A
V
P
G
T
Y
D
P
-
N
---
Q
P
I
I
R
I
Q
S
I
A
P
S
L
Q
V
I
T
-
S
K
Q
R
P
R
K
L
T
L
M
G
S
N
G
H
E
F
V
F
L
L
K
G
H
--
E
D
L
R
Q
D
E
R
V
M
Q
L
F
G
L
V
N
T
L
L
A
N
D
P
-
T
S
L
R
K
N
L
S
I
Q
R
Y
A
V
I
P
L
S
T
N
S
G
L
I
G
W
V
P
H
C
D
T
L
H
A
L
I
R
D
Y
R
E
K
K
K
I
L
L
N
I
E
H
R
I
M
L
R
-
M
-----
A
P
D
Y
-
D
H
----
L
T
L
M
Q
K
V
E
V
F
E
H
A
V
N
N
-
T
A
G
D
D
L
A
K
L
L
W
L
K
S
P
S
S
E
V
W
F
D
R
R
T
N
Y
T
R
S
L
A
V
M
S
M
V
G
Y
I
L
G
L
G
D
R
H
P
S
N
L
M
L
D
R
L
S
G
K
I
L
H
I
D
F
G
D
C
---
F
E
V
A
M
T
R
E
K
F
P
E
K
I
P
F
R
L
T
R
M
L
T
N
A
M
E
V
T
G
L
D
G
N
Y
R
I
T
C
H
T
V
M
E
V
L
R
E
H
K
D
S
V
M
A
V
L
E
A
F
V
Y
D
P
L
L
N
W
R
L
M
D
TNT-------------------------------------------------
A
L
N
K
-----------
K
A
I
Q
I
I
N
R
V
R
D
K
L
T
G
R
D
F
S
--
H
D
D
T
--
L
D
V
P
T
Q
V
E
L
L
I
K
Q
A
T
S
H
E
N
L
C
Q
C
Y
I
G
W
C
P
F
W
22
HHSearch
55.97
27%
-13
- C2 -
-
6EMK
-
TOR2_YEAST
A:
[106-2474]
-----------------------
N
E
L
S
T
T
L
T
S
L
A
R
E
V
S
A
E
Q
F
Q
R
F
S
---
N
S
L
N
--
N
K
I
F
E
L
I
H
G
F
T
S
S
E
K
I
G
G
I
L
A
V
D
T
L
I
S
F
Y
L
STEE
L
P
N
Q
T
S
R
L
A
N
Y
L
R
V
-
L
I
P
S
S
D
I
E
V
M
R
L
A
A
N
T
L
G
R
L
T
V
P
GG
T
L
T
S
D
F
V
E
F
E
V
R
T
C
I
D
W
L
T
L
T
A
DNNSSS
S
K
L
E
Y
R
R
H
A
A
L
L
I
I
K
A
L
A
D
N
S
P
Y
L
L
Y
P
Y
V
N
S
I
L
D
N
I
W
V
P
L
R
D
A
K
L
I
I
R
L
D
A
A
V
A
L
G
K
C
L
T
I
I
Q
D
R
D
P
A
-----------------------------
L
G
K
Q
W
-
F
Q
R
L
--------------
F
Q
G
C
T
H
G
L
S
L
-
N
T
N
D
S
V
H
A
T
L
L
V
F
R
--
E
L
L
S
L
K
A
P
Y
-
L
R
D
K
Y
D
D
I
Y
K
S
T
M
-
K
Y
---
K
E
Y
K
F
D
V
I
R
R
E
V
Y
A
I
L
P
L
L
A
A
------
F
D
P
A
I
F
T
K
K
Y
L
D
R
I
M
V
H
Y
L
R
Y
L
K
------
N
IDMNAAN
N
S
D
K
P
F
I
L
V
S
I
G
D
I
A
F
E
V
G
-
S
S
I
S
P
Y
M
T
L
I
L
D
N
I
R
E
G
L
R
T
K
FK
V
---
R
K
Q
F
E
K
D
L
F
Y
C
I
G
K
L
A
C
A
L
G
P
A
----
F
A
K
H
L
N
K
D
L
L
N
L
M
L
N
C
P
M
S
D
H
M
Q
E
T
L
M
I
L
N
E
K
I
P
S
L
E
-
S
T
V
N
S
R
I
L
N
L
L
S
I
S
L
S
G
E
K
F
I
-----------
Q
-
S
N
Q
Y
D
F
N
N
Q------
F
SIEKAR
K
S
R
N
Q
S
F
M
K
KTG
E
S
N
D
D
I
T
D
A
Q
I
L
I
Q
C
F
K
M
L
Q
L
I
-
H
H
--
Q
-----
Y
S
L
T
E
F
V
R
L
I
T
I
S
Y
I
E
H
E
D
S
S
V
R
K
L
A
A
L
T
S
-----
C
D
L
F
I
K
D
D
I
C
K
Q
T
S
V
H
A
L
H
S
V
S
E
V
L
S
K
L
L
M
I
A
I
T
D
P
V
A
E
I
R
L
E
---
I
L
Q
H
L
G
S
--------
N
F
D
P
Q
L
A
Q
---
P
D
N
L
R
L
L
F
M
A
L
N
D
E
-
I
F
G
I
Q
L
E
A
I
K
I
I
G
R
L
S
S
V
N
-----------
P
A
Y
V
V
P
S
L
R
K
T
L
L
E
L
L
T
Q
L
K
F
-----
S
N
M
P
K
K
K
E
E
S
A
T
L
L
C
T
L
I
N
S
S
D
E
-
V
A
K
P
Y
I
D
P
I
L
D
V
I
L
P
K
C
------
Q
D
A
--
S
S
A
V
A
S
T
A
L
K
V
L
G
E
L
S
V
---
V
G
G
K
EM
T
R
Y
L
K
----
E
L
M
P
L
I
I
N
T
F
Q
D
Q
-
S
N
S
F
K
R
D
A
-
A
L
T
T
L
G
Q
L
A
A
S
S
G
Y
V
V
G
P
L
L
D
Y
P
E
L
L
G
I
L
I
N
I
L
K
T
E
-
N
N
P
H
I
R
R
G
T
V
R
L
I
G
------------------------------------E
Y
Y
P
T
V
--
V
I
H
N
L
M
K
---
I
L
N
D
P
S
L
S
------
I
H
H
T
A
A
-------
I
Q
A
I
M
H
I
F
Q
N
L
G
L
R
C
-
V
S
F
L
D
Q
I
I
P
G
I
I
L
V
M
R
S
C
---
P
-
P
S
Q
L
D
F
Y
F
Q
Q
L
G
S
L
I
S
I
V
K
-------------
Q
H
I
R
P
H
V
E
K
I
Y
G
V
I
---
R
E
F
F
P
I
-
I
K
L
-
Q
I
T
I
I
S
---
V
I
E
S
I
S
K
A
L
E
G
E
F
K
R
F
V
P
E
T
L
T
F
F
L
D
I
L
E
N
D
Q
S
N
---
K
R
I
V
P
I
R
I
L
K
S
L
V
T
F
G
P
N
L
E
DYSH
L
I
M
P
I
V
V
R
M
T
E
Y
S
---
A
G
S
L
K
K
I
S
I
I
T
L
G
R
L
A
-
K
N
I
N
L
S
E
M
S
S
R
I
V
Q
A
L
V
R
I
L
N
N
G
---------
D
R
E
L
T
K
A
T
M
N
T
L
S
L
L
L
L
Q
L
G
T
D
F
V
V
F
V
P
V
I
N
K
A
L
L
R
N
R
---
I
Q
H
S
V
Y
D
Q
L
V
----------------------
N
K
L
L
N
N
E
C
L
P
T
N
I
I
F
D
K
-------
E
N
E
V
P
E
R
K
N
Y
E
D
E
M
Q
V
T
K
L
P
V
N
Q
N
I
L
K
N
A
W
Y
C
S
Q
Q
K
-
T
K
E
D
W
Q
E
W
I
R
R
L
S
I
Q
L
L
K
E
S
P
----
S
A
C
L
R
-
S
C
S
--------
S
L
V
S
V
Y
Y
P
L
A
R
E
L
F
N
A
S
F
S
S
C
W
V
E
L
Q
T
S
Y
Q
E
D
------------------------------
L
V
E
F
M
E
H
D
-
D
K
---------------------------
P
L
-
P
I
P
I
H
T
L
G
K
Y
A
Q
K
C
H
A
----
F
A
K
A
L
H
Y
K
E
V
E
F
L
E
E
----
P
--
K
N--
S
-
T
I
E
A
L
I
S
I
N
N
Q
L
H
Q
T
D
S
A
I
G
I
L
K
H
A
Q
Q
H
N
E
L
Q
-
L
K
E
T
W
Y
E
K
-
L
Q
R
W
E
D
A
L
A
A
Y
N
E
K
E
A
A
G
E
D
-----------------------------------------------
S
--
V
E
V
M
M
G
K
L
R
S
L
Y
A
L
G
E
W
E
E
L
S
----
K
L
A
S
E
K
W
G
T
A
K
P
--------
E
V
K
K
A
M
A
P
L
A
A
G
A
A
W
G
L
E
Q
W
D
E
I
A
Q
---
Y
T
S
V
M
K
-----
S
Q
S
P
D
K
E
F
Y
D
A
I
L
C
L
H
R
N
-----
N
F
K
K
A
E
V
H
I
F
N
A
R
D
L
L
V
T
E
L
S
A
L
V
--
N
E
S
Y
N
R
A
Y
N
V
V
V
R
A
Q
I
I
A
E
L
E
E
I
I
----
K
Y
K
K
L
P
Q
N
---------
S
D
K
R
L
T
M
R
E
T
W
N
T
R
L
L
G
C
Q
K
N
I
D
V
W
Q
R
I
L
R
V
R
S
L
V
I
K
P
K
------------------
E
D
A
Q
V
R
I
K
F
A
N
L
C
R
K
S
G
R
M
A
L
A
K
K
V
L
N
T
L
L
E
E
T
D
D
P
D
-
H
P
N
T
A
K
A
S
P
P
V
V
Y
A
Q
L
K
Y
L
W
A
T
G
-----------------------
L
Q
D
E
A
--
L
-----
K
Q
L
I
N
F
T
S
R
M
A
----------
H
DLV
E
----------
D
Y
T
K
L
L
A
R
C
F
L
K
Q
G
------------
E
W
RVCLQPKWRL
S
N
P
D
S
I
L
---------
G
S
Y
L
L
A
T
H
F
D
N
T
W
Y
K
A
W
H
N
W
A
----
L
A
N
F
E
V
I
S
--SN
L
------
I
H
-------------------
R
H
------------------
V
I
P
-------------------
A
I
K
G
F
F
H
S
I
S
L
-
S
E
--
S
S
S
L
Q
D
A
L
R
L
L
T
L
W
F
T
F
G
G
I
-------------------
P
E
A
T
Q
A
M
H
E
G
F
N
L
I
Q
I
G
T
W
L
E
V
L
P
Q
L
I
S
R
I
H
Q
P
N
Q
I
V
S
R
S
L
L
S
L
L
S
D
L
G
K
A
H
P
Q
A
L
V
Y
P
L
M
V
A
I
K
S
E
S
L
S
---
R
Q
K
A
A
L
S
I
I
E
K
M
R
I
---
H
S
P
V
L
V
D
Q
A
E
L
V
S
H
E
L
I
-
R
M
A
V
L
W
H
E
Q
W
Y
E
G
L
D
D
----
A
S
R
----
Q
F
F
G
E
H
N
T
--
E
-
K
M
F
A
A
L
E
P
L
Y
E
M
L
K
R
G
P
E
T
L
R
E
I
S
F
Q
N
S
F
G
R
D
L
N
D
A
Y
E
W
L
M
N
Y
K
K
S
K
D
V
S
N
L
N
Q
A
W
D
I
Y
Y
N
V
F
R
K
I
G
K
Q
L
P
Q
L
-
Q
T
L
E
L
Q
H
V
S
-
P
K
L
L
S
A
H
---
D
L
E
L
A
V
P
G
T
R
A
S
G
G
---
K
P
I
V
K
I
S
K
F
E
P
V
F
S
V
I
S
-
S
K
Q
R
P
R
K
F
C
I
K
G
S
D
G
K
D
Y
K
Y
V
L
K
G
H
--
E
D
I
R
Q
D
S
L
V
M
Q
L
F
G
L
V
N
T
L
L
Q
N
D
A
E
C
F
-
R
R
H
L
D
I
Q
Q
Y
P
A
I
P
L
S
P
K
S
G
L
L
G
W
V
P
N
S
D
T
F
H
V
L
I
R
E
H
R
E
A
K
K
I
P
L
N
I
E
H
W
V
M
L
Q
-
M
A
-----
P
D
Y
-
D
N
----
L
T
L
L
Q
K
V
E
V
F
T
Y
A
L
N
N
-
T
E
G
Q
D
L
Y
K
V
L
W
L
K
S
R
S
S
E
T
W
L
E
R
R
T
T
Y
T
R
S
L
A
V
M
S
M
T
G
Y
I
L
G
L
G
D
R
H
P
S
N
L
M
L
D
R
I
T
G
K
V
I
H
I
D
F
G
D
C
---
F
E
A
A
I
L
R
E
K
F
P
E
K
V
P
F
R
L
T
R
M
L
T
Y
A
M
E
V
S
G
I
E
G
S
F
R
I
T
C
E
N
V
M
K
V
L
R
D
N
K
G
S
L
M
A
I
L
E
A
F
A
F
D
P
L
I
N
W
G
F
D
L
---
P
T
K
K
I
E
E
E
T
G
I
Q
L
--
P
--
V
M
N
A
N
E
L
L
S
N
G
A
I
T
-
E
E
E
-
V
Q
------------
R
V
E
N
E
H
K
N
A
I
R
N
A
R
A
M
L
V
L
K
R
I
T
D
K
L
T
G
N
D
I
R
--
R
--
F
N
D
L
D
V
P
E
Q
V
D
K
L
I
Q
Q
A
T
S
V
E
N
L
C
Q
H
Y
I
G
W
C
P
F
W
2
PsiBlast_PDB
55.42
40%
-102
- C2 -
-
5H64
-
MTOR_HUMAN
A:
[1884-2549]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
Q
G
F
F
R
S
I
S
L
-
S
R
G
N
N
--
L
Q
D
T
L
R
V
L
T
L
W
F
D
Y
G
H
W
-------------------
P
D
V
N
E
A
L
V
E
G
V
K
A
I
Q
I
D
T
W
L
Q
V
I
P
Q
L
I
A
R
I
D
T
P
R
P
L
V
G
R
L
I
H
Q
L
L
T
D
I
G
R
Y
H
P
Q
A
L
I
Y
P
L
T
V
A
S
K
S
T
T
T
A
---
R
H
N
A
A
N
K
I
L
K
N
M
C
E
---
H
S
N
T
L
V
Q
Q
A
M
M
V
S
E
E
L
I
-
R
V
A
I
L
W
H
E
M
W
H
E
G
L
E
E
----
A
S
R
----
L
Y
F
G
E
R
N
V
--
K
-
G
M
F
E
V
L
E
P
L
H
A
M
M
E
R
G
P
Q
T
L
K
E
T
S
F
N
Q
A
Y
G
R
D
L
M
E
A
Q
E
W
C
R
K
Y
M
K
S
G
N
V
K
D
L
T
Q
A
W
D
L
Y
Y
H
V
F
R
R
I
S
K
Q
L
P
Q
L
-
T
S
L
E
L
Q
Y
V
S
-
P
K
L
L
M
C
R
---
D
L
E
L
A
V
P
G
T
Y
D
P
-
N
---
Q
P
I
I
R
I
Q
S
I
A
P
S
L
Q
V
I
T
-
S
K
Q
R
P
R
K
L
T
L
M
G
S
N
G
H
E
F
V
F
L
L
K
G
H
--
E
D
L
R
Q
D
E
R
V
M
Q
L
F
G
L
V
N
T
L
L
A
N
D
P
-
T
S
L
R
K
N
L
S
I
Q
R
Y
A
V
I
P
L
S
T
N
S
G
L
I
G
W
V
P
H
C
D
T
L
H
A
L
I
R
D
Y
R
E
K
K
K
I
L
L
N
I
E
H
R
I
M
L
R
-
M
-----
A
P
D
Y
-
D
H
----
L
T
L
M
Q
K
V
E
V
F
E
H
A
V
N
N
-
T
A
G
D
D
L
A
K
L
L
W
L
K
S
P
S
S
E
V
W
F
D
R
R
T
N
Y
T
R
S
L
A
V
M
S
M
V
G
Y
I
L
G
L
G
D
R
H
P
S
N
L
M
L
D
R
L
S
G
K
I
L
H
I
D
F
G
D
C
---
F
E
V
A
M
T
R
E
K
F
P
E
K
I
P
F
R
L
T
R
M
L
T
N
A
M
E
V
T
G
L
D
G
N
Y
R
I
T
C
H
T
V
M
E
V
L
R
E
H
K
D
S
V
M
A
V
L
E
A
F
V
Y
D
P
L
L
N
W
R
L
M
D
T
N
T-------------------------------------------------
A
L
N
K
-----------
K
A
I
Q
I
I
N
R
V
R
D
K
L
T
G
R
D
F
S
--
H
D
D
T
--
L
D
V
P
T
Q
V
E
L
L
I
K
Q
A
T
S
H
E
N
L
C
Q
C
Y
I
G
W
C
P
F
W
12
PsiBlast_PDB
51.37
40%
-108
- C2 -
-
3JBZ
2
A:
[500-1165]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
Q
G
F
F
R
S
I
S
L
-
S
R
G
N
N
--
L
Q
D
T
L
R
V
L
T
L
W
F
D
Y
G
H
W
-------------------
P
D
V
N
E
A
L
V
E
G
V
K
A
I
Q
I
D
T
W
L
Q
V
I
P
Q
L
I
A
R
I
D
T
P
R
P
L
V
G
R
L
I
H
Q
L
L
T
D
I
G
R
Y
H
P
Q
A
L
I
Y
P
L
T
V
A
S
K
S
T
T
T
A
---
R
H
N
A
A
N
K
I
L
K
N
M
C
E
---
H
S
N
T
L
V
Q
Q
A
M
M
V
S
E
E
L
I
-
R
V
A
--------------------------------------------------------------------------------------------------------------
T
S
L
E
L
Q
Y
V
S
-
P
K
L
L
M
C
R
---
D
L
E
L
A
V
P
G
T
Y
D
P
-
N
---
Q
P
I
I
R
I
Q
S
I
A
P
S
L
Q
V
I
T
-
S
K
Q
R
P
R
K
L
T
L
M
G
S
N
G
H
E
F
V
F
L
L
K
G
H
--
E
D
L
R
Q
D
E
R
V
M
Q
L
F
G
L
V
N
T
L
L
A
N
D
P
-
T
S
L
R
K
N
L
S
I
Q
R
Y
A
V
I
P
L
S
T
N
S
G
L
I
G
W
V
P
H
C
D
T
L
H
A
L
I
R
D
Y
R
E
K
K
K
I
L
L
N
I
E
H
R
I
M
L
R
-
M
-----
A
P
D
Y
-
D
H
----
L
T
L
M
Q
K
V
E
V
F
E
H
A
V
N
N
-
T
A
G
D
D
L
A
K
L
L
W
L
K
S
P
S
S
E
V
W
F
D
R
R
T
N
Y
T
R
S
L
A
V
M
S
M
V
G
Y
I
L
G
L
G
D
R
H
P
S
N
L
M
L
D
R
L
S
G
K
I
L
H
I
D
F
G
D
C
---
F
E
V
A
M
T
R
E
K
F
P
E
K
I
P
F
R
L
T
R
M
L
T
N
A
M
E
V
T
G
L
D
G
N
Y
R
I
T
C
H
T
V
M
E
V
L
R
E
H
K
D
S
V
M
A
V
L
E
A
F
V
Y
D
P
L
L
N
W
R
L
M
D
TNT-------------------------------------------------
A
L
N
K
-----------
K
A
I
Q
I
I
N
R
V
R
D
K
L
T
G
R
D
F
S
--
H
D
D
T
--
L
D
V
P
T
Q
V
E
L
L
I
K
Q
A
T
S
H
E
N
L
C
Q
C
Y
I
G
W
C
P
F
W
63
Fugue
46.63
36%
9
- C2 -
-
4JSP
1
MTOR_HUMAN
A:
[10-1174]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
A
A
K
C
R
A
----
Y
A
K
A
L
H
Y
K
E
L
E
F
Q
K
G
----
P
T-
P
---
A
-
I
L
E
S
L
I
S
I
N
N
K
L
Q
Q
P
E
A
A
A
G
V
L
E
Y
A
M
K
H
-
F
G
E
L
E
I
Q
A
T
W
Y
E
K
L
H
E
W
E
D
A
L
V
A
Y
D
K
K
M
D
T
-------------------------------------------------
N
K
D
D
P
E
L
M
L
G
R
M
R
C
L
E
A
L
G
E
W
G
Q
L
H
----
Q
Q
C
C
E
K
W
T
L
V
N
D
--------
E
T
Q
A
K
M
A
R
M
A
A
A
A
A
W
G
L
G
Q
W
D
S
M
E
E
---
Y
T
C
M
I
P
-----
R
D
T
H
D
G
A
F
Y
R
A
V
L
A
L
H
Q
D
-----
L
F
S
L
A
Q
Q
C
I
D
K
A
R
D
L
L
D
A
E
L
T
A
M
A
--
G
E
S
Y
S
R
A
Y
G
A
M
V
S
C
H
M
L
S
E
L
E
E
V
I
----
Q
Y
K
L
V
P
E
------------
R
R
E
I
I
R
Q
I
W
W
E
R
L
Q
G
C
Q
R
I
V
E
D
W
Q
K
I
L
M
V
R
S
L
V
V
S
P
H
------------------
E
D
M
R
T
W
L
K
Y
A
S
L
C
G
K
S
G
R
L
A
L
A
H
K
T
L
V
L
L
L
G
V
D
P
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R
Q
L
D
H
P
L
P
T
V
H
P
Q
V
T
Y
A
Y
M
K
N
M
W
K
S
A
--------------------
R
--
K
I
D
-
A
--
F
-
Q
H
M
Q
H
F
V
Q
T
M
Q
Q
Q
A
Q
HAIATED
Q
Q
H
K
---
Q
----------
E
L
H
K
L
M
A
R
C
F
L
K
L
G
------------
E
W
----------
Q
L
N
L
Q
G
I
NEST
I
P
K
V
L
Q
Y
Y
S
A
A
T
E
H
D
R
S
W
Y
K
A
W
H
A
W
A
----
V
M
N
F
E
A
V
L
H
Y
--
K
------
H
Q
-------------------
N
Q
------------------
A
R
D
E
KK
K
V
T
E
D
L
S
K
T
L
L
M
Y
T
V
P
A
V
Q
G
F
F
R
S
I
S
L
-
S
R
G
N
N
--
L
Q
D
T
L
R
V
L
T
L
W
F
D
Y
G
H
W
-------------------
P
D
V
N
E
A
L
V
E
G
V
K
A
I
Q
I
D
T
W
L
Q
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P
Q
L
I
A
R
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P
R
P
L
V
G
R
L
I
H
Q
L
L
T
D
I
G
R
Y
H
P
Q
A
L
I
Y
P
L
T
V
A
S
K
S
T
T
T
A
---
R
H
N
A
A
N
K
I
L
K
N
M
C
E
---
H
S
N
T
L
V
Q
Q
A
M
M
V
S
E
E
L
I
-
R
V
A
I
L
W
H
E
M
W
H
E
G
L
E
E
----
A
S
R
----
L
Y
F
G
E
R
N
V
--
K
-
G
M
F
E
V
L
E
P
L
H
A
M
M
E
R
G
P
Q
T
L
K
E
T
S
F
N
Q
A
Y
G
R
D
L
M
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A
Q
E
W
C
R
K
Y
M
K
S
G
N
V
K
D
L
T
Q
A
W
D
L
Y
Y
H
V
F
R
R
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S
K
Q
L
P
Q
L
-
T
S
L
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L
Q
Y
V
S
-
P
K
L
L
M
C
R
---
D
L
E
L
A
V
P
G
T
Y
D
-
P
N
---
Q
P
I
I
R
I
Q
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I
A
P
S
L
Q
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I
T
-
S
K
Q
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R
K
L
T
L
M
G
S
N
G
H
E
F
V
F
L
L
K
G
H
--
E
D
L
R
Q
D
E
R
V
M
Q
L
F
G
L
V
N
T
L
L
A
N
D
-
P
T
S
L
R
K
N
L
S
I
Q
R
Y
A
V
I
P
L
S
T
N
S
G
L
I
G
W
V
P
H
C
D
T
L
H
A
L
I
R
D
Y
R
E
K
K
K
I
L
L
N
I
E
H
R
I
M
L
R
-
M
-----
A
P
D
Y
-
D
H
----
L
T
L
M
Q
K
V
E
V
F
E
H
A
V
N
N
-
T
A
G
D
D
L
A
K
L
L
W
L
K
S
P
S
S
E
V
W
F
D
R
R
T
N
Y
T
R
S
L
A
V
M
S
M
V
G
Y
I
L
G
L
G
D
R
H
P
S
N
L
M
L
D
R
L
S
G
K
I
L
H
I
D
F
G
D
C
---
F
E
V
A
M
T
R
E
K
F
P
E
K
I
P
F
R
L
T
R
M
L
T
N
A
M
E
V
T
G
L
D
G
N
Y
R
I
T
C
H
T
V
M
E
V
L
R
E
H
K
D
S
V
M
A
V
L
E
A
F
V
Y
D
P
L
L
N
W
R
L
M
D
---
T
N
T
A
---------------------------------------------------------
L
N
K
K
A
I
Q
I
I
N
R
V
R
D
K
L
T
G
R
D
F
----
S
H
D
D
T
L
D
V
P
T
Q
V
E
L
L
I
K
Q
A
T
S
H
E
N
L
C
Q
C
Y
I
G
W
C
P
F
W
18
PsiBlast_PDB
41.57
39%
-173
- C2 -
-
1AUE
-
MTOR_HUMAN
A:
[2023-2114]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
W
H
E
M
W
H
E
G
L
E
E
----
A
S
R
----
L
Y
F
G
E
R
N
V
--
K
-
G
M
F
E
V
L
E
P
L
H
A
M
M
E
R
G
P
Q
T
L
K
E
T
S
F
N
Q
A
Y
G
R
D
L
M
E
A
Q
E
W
C
R
K
Y
M
K
S
G
N
V
K
D
L
T
Q
A
W
D
L
Y
Y
H
V
F
R
R
I
S
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
Fugue
41.40
35%
-162
* C2 *
-
1NSG
1
B:
[1-94]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
I
L
W
H
E
M
W
H
E
G
L
E
E
----
A
S
R
----
L
Y
F
G
E
R
N
V
--
K
-
G
M
F
E
V
L
E
P
L
H
A
M
M
E
R
G
P
Q
T
L
K
E
T
S
F
N
Q
A
Y
G
R
D
L
M
E
A
Q
E
W
C
R
K
Y
M
K
S
G
N
V
K
D
L
T
Q
A
W
D
L
Y
Y
H
V
F
R
R
I
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
40.98
16%
-2
- C2 -
-
5OJS
-
TRA1_YEAST
T:
[2560-3767]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
----
S
D
F
I
D
-
S
L
I
--------
E
I
F
Y
Q
D
P
K
A
I
H
R
A
W
V
T
L
F
P
Q
V
Y
K
S
I
P
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N
E
K
Y
G
F
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R
S
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T
L
L
S
K
P
Y
H
T
R
QI
S
S
R
T
N
V
I
N
M
L
L
D
S
---
I
S
K
I
-
E
----------------------------
S
L
-
E
L
P
P
H
L
V
K
Y
L
A
I
S
Y
N
A
----
W
Y
Q
S
I
N
I
L
E
S
I
Q
S
N
T
SIDN
T
KI
I
E--
A
-
N
E
D
A
L
L
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L
Y
V
N
L
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E
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M
F
Y
G
L
W
R
R
R
A
K
Y
-
T
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-
N
I
G
L
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Y
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Q
-
I
G
L
W
D
K
A
Q
Q
L
Y
E
V
A
Q
V
K
A
R
S
G
-------------------------------------
A
L
P
Y
S
Q
S
E
Y
A
---
L
W
E
D
N
W
I
Q
C
A
E
K
L
Q
H
W
D
V
L
T
----
E
L
A
K
H
E
G
------------------
F
T
D
L
L
L
E
C
G
W
R
V
A
D
W
N
S
D
R
D
---
A
L
E
Q
S
V
KSVMD
V
P
T
P
R
R
Q
M
F
K
T
F
L
A
L
Q
N
F
AESRK
G
D
Q
E
V
R
K
L
C
D
E
G
I
Q
L
S
L
I
K
W
V
S
L
P
--
I
R
Y
T
P
A
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K
W
L
L
H
G
F
Q
Q
Y
M
E
F
L
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A
T
----
Q
I
Y
A
N
L
H
T
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TVQNLD
S
K
A
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I
K
R
I
L
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W
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D
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N
M
W
N
D
L
V
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W
R
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A
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Q
V
I
NNAYLPLIPALQAYRGYH
E
I
A
W
V
I
N
R
F
A
H
V
A
R
K
H
N
M
P
D
V
C
I
S
Q
L
A
R
I
Y
T
L
P
N
I
E
------
I
Q
E
A
F
L
K
L
R
E
Q
A
K
C
H
Y
Q
N
M
--------------------
N
--
E
L
T
T
G
--
L
D
V
I
S
N
T
N
L
V
Y
F
G
T
V
-
Q
----------
K
---
A
----------
E
F
F
T
L
K
G
M
F
L
S
K
L
R
-------------------------
A
Y
E
E
A
N
---------
Q
A
F
A
T
A
V
Q
I
D
L
N
L
A
K
A
W
A
Q
W
G
----
F
F
N
D
R
R
L
S
E
E
P-
N
------
N
I
-------------------
S
F
------------------
A
S
N
-------------------
A
I
S
C
Y
L
Q
A
A
G
L
Y
K
N
--
S
K
I
R
E
L
L
C
R
I
L
W
L
I
S
I
D
D
A
S
-------------------
G
M
L
T
N
A
F
D
S
F
R
G
E
I
P
V
W
Y
W
I
T
F
I
P
Q
L
L
T
S
L
S
H
K
E
A
---
N
M
V
R
H
I
L
I
R
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A
K
S
Y
P
Q
A
L
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F
Q
L
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T
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D
F
A
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I
QRQ
P
W
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Y
L
Q
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L
N
N
I
L
K
T
---
A
Y
P
L
L
A
L
S
L
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S
L
V
A
Q
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N
D
R
F
K
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T
T
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D
L
F
R
L
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N
V
LLID
G
T
L
NYNR
L
P
F
P
R
K
N
P
KL
P
E
N
T
E
K
N
L
V
K
----
F
---
S
T
T
L
L
A
P
Y
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P
K
F
N
A
D
F
I
D
------------
N
K
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Y
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R
L
R
Y
W
R
R
R
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V
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R
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C
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K
K
G
F
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P
D
D
I
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D
F
M
A
D
K
L
N
-----
A
A
H
D
D
A
LPAP
D
M
T
I
L
K
V
E
I
F
N
S
I
Q
T
M
F
V
P
S
N
V
L
K
D
H
F
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L
F
T
Q
F
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D
F
W
L
F
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K
Q
F
A
S
Q
Y
S
S
F
V
F
M
S
Y
M
M
M
I
N
N
R
T
P
H
K
I
H
V
D
K
T
S
G
N
V
F
T
L
E
M
L
P
S
DLS
L
P
P
D
S
P
I
F
H
N
N
E
P
V
P
F
R
L
T
P
N
I
Q
S
L
I
G
D
S
A
L
E
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F
A
V
N
L
F
T
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S
R
A
L
I
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P
D
N
E
L
N
T
Y
L
A
L
F
I
R
D
E
I
I
S
W
F
S
N
L
---
H
R
P
I
I
E
--
N
----------------------------------------------
P
Q
L
R
E
M
V
Q
T
N
V
D
L
I
I
R
K
V
A
----
Q
L
G
H
L
----
N
S
T
P
T
V
T
T
Q
F
I
L
D
C
I
G
S
A
V
S
P
R
N
L
A
R
T
D
V
N
F
M
P
W
F
67
Fugue
39.30
16%
-44
- C1 -
-
3W3W
-
IMB3_YEAST
A:
[3-1077]
---------------------------------------------------------------------------------------------------------------
A
L
P
E
E
V
N
R
T
L
L
Q
I
V
Q
A
--
F
A
S
D
N
Q
I
R
S
V
A
E
K
A
L
S
E
E
W
I
T
E
------
N
N
---
I
E
Y
L
L
T
F
L
A
E
Q
A
A
F
S
Q
D
T
T
V
A
A
L
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A
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L
F
R
K
L
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L
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E
V
L
A
Q
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R
S
S
L
L
K
G
F
L
S
E
R
A
D
S
-----------------------------
I
R
H
K
L
-
S
D
A
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A
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C
VQDDLPAW
P
E
L
L
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A
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G
N
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Y
L
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----------
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N
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L
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L
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R
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L
D
D
-
G
------
K
-------
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D
A
L
A
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F
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S
L
I
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L
V
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L
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K
-
L
F
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D
M
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T
D
M
V
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K
N
---
K
DLE
P
P
A
-
R
T
T
A
L
E
L
L
T
V
F
S
E
N
A
-
P
Q
---
M
C
K
------------------------------
S
N
Q
N
Y
G
Q
T
L
V
M
V
T
L
I
M
M
T
E
V
S
I
D
D
D
----------------
D
A
A
E
W
I
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-------
S
-------------------
D
D
T
D
D
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V
T
Y
D
H
A
R
Q
A
L
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R
V
-
A
L
K
L
G
G
----
E
Y
L
A
A
P
L
F
Q
Y
L
Q
Q
M
I
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T
E
W
R
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F
A
A
M
M
A
L
-----
S
S
A
---
A
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G
C
A
D
V
L
I
G
E
----
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P
K
I
L
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P
R
V
Q
Y
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C
C
N
V
L
G
Q
I
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T
--------
D
F
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A
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D
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L
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A
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K
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H
A
A
A
A
L
V
N
F
S
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F
A
-----------
S
K
D
I
L
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P
Y
L
D
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L
L
T
N
L
L
V
L
L
Q
-----
S
N
K
L
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A
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A
K
N
-
K
F
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K
Y
Y
D
T
L
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P
L
L
L
N
V
L
------
K
V
---
N
S
V
L
K
G
K
C
M
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C
A
T
L
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F
A
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--
H
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--
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A
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D
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L
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A
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A
A
N
F
Q
Q
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P
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V
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--
K
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A
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L
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D
K
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L
L
Q
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Y
A
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L
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------
G
Q
F
A
V
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V
K
E
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M
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---
E
I
A
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A
-
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-------
A
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--
A
A
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DNCLS
E
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A
A
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D
G
S
K
L
E
E
N
R
S
S
T
E
N
A
S
A
A
------
I
A
K
I
L
Y
A
Y
N
S
N
I
P
--
D
T
Y
T
A
N
W
F
K
T
L
P
T
I
T
D
K
E
A
A
S
F
N
Y
Q
F
L
S
Q
V
C
A
Q
S
-------
N
I
S
A
V
V
D
S
V
I
Q
A
L
N
E
R
S
L
T
V
I
S
S
V
K
K
L
L
G
F
L
P
S
S
D
A
M
-
A
I
F
N
R
Y
P
A
D
I
M
E
K
V
H
K
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
39.02
40%
-
- C2 -
-
4JSN
-
MTOR_HUMAN
B:
[1884-2549]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
Q
G
F
F
R
S
I
S
L
-
S
R
G
N
N
--
L
Q
D
T
L
R
V
L
T
L
W
F
D
Y
G
H
W
-------------------
P
D
V
N
E
A
L
V
E
G
V
K
A
I
Q
I
D
T
W
L
Q
V
I
P
Q
L
I
A
R
I
D
T
P
R
P
L
V
G
R
L
I
H
Q
L
L
T
D
I
G
R
Y
H
P
Q
A
L
I
Y
P
L
T
V
A
S
K
S
T
T
T
A
---
R
H
N
A
A
N
K
I
L
K
N
M
C
E
---
H
S
N
T
L
V
Q
Q
A
M
M
V
S
E
E
L
I
-
R
V
A
I
L
W
H
E
M
W
H
E
G
L
E
E
----
A
S
R
----
L
Y
F
G
E
R
N
V
--
K
-
G
M
F
E
V
L
E
P
L
H
A
M
M
E
R
G
P
Q
T
L
K
E
T
S
F
N
Q
A
Y
G
R
D
L
M
E
A
Q
E
W
C
R
K
Y
M
K
S
G
N
V
K
D
L
T
Q
A
W
D
L
Y
Y
H
V
F
R
R
I
S
K
Q
L
P
Q
L
-
T
S
L
E
L
Q
Y
V
S
-
P
K
L
L
M
C
R
---
D
L
E
L
A
V
P
G
T
Y
D
P
-
N
---
Q
P
I
I
R
I
Q
S
I
A
P
S
L
Q
V
I
T
-
S
K
Q
R
P
R
K
L
T
L
M
G
S
N
G
H
E
F
V
F
L
L
K
G
H
--
E
D
L
R
Q
D
E
R
V
M
Q
L
F
G
L
V
N
T
L
L
A
N
D
P
-
T
S
L
R
K
N
L
S
I
Q
R
Y
A
V
I
P
L
S
T
N
S
G
L
I
G
W
V
P
H
C
D
T
L
H
A
L
I
R
D
Y
R
E
K
K
K
I
L
L
N
I
E
H
R
I
M
L
R
-
M
-----
A
P
D
Y
-
D
H
----
L
T
L
M
Q
K
V
E
V
F
E
H
A
V
N
N
-
T
A
G
D
D
L
A
K
L
L
W
L
K
S
P
S
S
E
V
W
F
D
R
R
T
N
Y
T
R
S
L
A
V
M
S
M
V
G
Y
I
L
G
L
G
D
R
H
P
S
N
L
M
L
D
R
L
S
G
K
I
L
H
I
D
F
G
D
C
---
F
E
V
A
M
T
R
E
K
F
P
E
K
I
P
F
R
L
T
R
M
L
T
N
A
M
E
V
T
G
L
D
G
N
Y
R
I
T
C
H
T
V
M
E
V
L
R
E
H
K
D
S
V
M
A
V
L
E
A
F
V
Y
D
P
L
L
N
W
R
L
M
D
TNT-------------------------------------------------
A
L
N
K
-----------
K
A
I
Q
I
I
N
R
V
R
D
K
L
T
G
R
D
F
S
--
H
D
D
T
--
L
D
V
P
T
Q
V
E
L
L
I
K
Q
A
T
S
H
E
N
L
C
Q
C
Y
I
G
W
C
P
F
W
1
PsiBlast_PDB
37.74
31%
31
- C2 -
-
6EMK
-
TOR2_YEAST
A:
[1218-2474]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
V
N
Q
N
I
L
K
N
A
W
Y
C
-
S
Q
Q
K
T
K
E
D
W
Q
E
W
I
R
R
L
S
I
Q
L
L
K
E
S
P
----
S
A
C
L
R
S
C
S
S
---------
L
V
S
V
Y
Y
P
L
A
R
E
L
F
N
A
S
F
S
S
C
W
----
V
E
L
Q
T
S
Y
Q
E
D
--------------------------
L
V
E
F
M
E
H
D
-
D
K
---------------------------
P
L
-
P
I
P
I
H
T
L
G
K
Y
A
Q
K
C
H
A
----
F
A
K
A
L
H
Y
K
E
V
E
F
L
E
E
----
P
--
K
---
N
S
T
I
E
A
L
I
S
I
N
N
Q
L
H
Q
T
D
S
A
I
G
I
L
K
H
A
Q
Q
H
-
N
E
L
Q
L
K
E
T
W
Y
E
K
-
L
Q
R
W
E
D
A
L
-------------------------------------------------
A
A
Y
N
E
K
E
A
A
G
E
D
S
V
E
V
M
M
G
K
L
R
S
L
Y
A
L
G
E
W
E
E
L
S
K
L
AS
E
K
W
G
------------
T
A
K
P
E
V
K
K
A
M
A
P
L
A
A
G
A
A
W
G
L
E
Q
W
D
E
I
A
Q
Y
T
S
V
M
K
S
Q
S
-----
P
D
K
E
F
Y
---
D
A
I
L
C
L
H
R
N
-----
N
F
K
K
A
E
V
H
I
F
N
A
R
D
L
L
V
T
E
L
S
A
L
V
--
N
E
S
Y
N
R
A
Y
N
V
V
V
R
A
Q
I
I
A
E
L
E
E
I
I
KYKK
L
P
Q
N
S
D
K
R
L
------
T
-------
M
R
E
T
W
N
T
R
L
L
G
C
Q
K
N
I
D
V
W
Q
R
I
L
R
V
R
S
L
V
I
K
P
K
------------------
E
D
A
Q
V
R
I
K
F
A
N
L
C
R
K
S
G
R
M
A
L
A
K
K
V
L
N
T
L
L
E
E
T
D
D
P
D
H
P
N
T
A
K
-
A
S
P
P
V
V
Y
A
Q
L
K
Y
L
W
A
T
G
L
Q
D
E
A
L
K
Q
L
I
N
F
T
S
RMAHDL--------------------------
V
----------
E
--------------
D
Y
T
K
L
L
A
R
C
F
L
K
Q
G
EWRVCLQPKWRL
S
N
----------
P
D
S
I
--
L
---------
G
S
Y
L
L
A
T
H
F
D
N
T
W
Y
K
A
W
H
N
W
A
----
L
A
N
F
E
V
I
S
-------------------------------------------------------SNLIHRHVIP---------
A
I
K
G
F
F
H
S
I
S
---
L
S
E
S
S
S
L
Q
D
A
L
R
L
L
T
L
W
F
T
F
G
G
I
-------------------
P
E
A
T
Q
A
M
H
E
G
F
N
L
I
Q
I
G
T
W
L
E
V
L
P
Q
L
I
S
R
I
H
Q
P
N
Q
I
V
S
R
S
L
L
S
L
L
S
D
L
G
K
A
H
P
Q
A
L
V
Y
P
L
M
V
A
I
K
S
E
S
L
S
---
R
Q
K
A
A
L
S
I
I
E
K
M
R
I
---
H
S
P
V
L
V
D
Q
A
E
L
V
S
H
E
L
I
-
R
M
A
V
L
W
H
E
Q
W
Y
E
G
L
D
D
----
A
S
R
----
Q
F
F
G
E
H
N
T
--
E
-
K
M
F
A
A
L
E
P
L
Y
E
M
L
K
R
G
P
E
T
L
R
E
I
S
F
Q
N
S
F
G
R
D
L
N
D
A
Y
E
W
L
M
N
Y
K
K
S
K
D
V
S
N
L
N
Q
A
W
D
I
Y
Y
N
V
F
R
K
I
G
K
Q
L
P
Q
L
-
Q
T
L
E
L
Q
H
V
S
-
P
K
L
L
S
A
H
---
D
L
E
L
A
V
P
G
T
R
A
S
G
G
---
K
P
I
V
K
I
S
K
F
E
P
V
F
S
V
I
S
-
S
K
Q
R
P
R
K
F
C
I
K
G
S
D
G
K
D
Y
K
Y
V
L
K
G
H
--
E
D
I
R
Q
D
S
L
V
M
Q
L
F
G
L
V
N
T
L
L
Q
N
D
A
E
C
F
R
R
-
H
L
D
I
Q
Q
Y
P
A
I
P
L
S
P
K
S
G
L
L
G
W
V
P
N
S
D
T
F
H
V
L
I
R
E
H
R
E
A
K
K
I
P
L
N
I
E
H
W
V
M
L
Q
-
M
-----
A
P
D
Y
-
D
N
----
L
T
L
L
Q
K
V
E
V
F
T
Y
A
L
N
N
-
T
E
G
Q
D
L
Y
K
V
L
W
L
K
S
R
S
S
E
T
W
L
E
R
R
T
T
Y
T
R
S
L
A
V
M
S
M
T
G
Y
I
L
G
L
G
D
R
H
P
S
N
L
M
L
D
R
I
T
G
K
V
I
H
I
D
F
G
D
C
---
F
E
A
A
I
L
R
E
K
F
P
E
K
V
P
F
R
L
T
R
M
L
T
Y
A
M
E
V
S
G
I
E
G
S
F
R
I
T
C
E
N
V
M
K
V
L
R
D
N
K
G
S
L
M
A
I
L
E
A
F
A
F
D
P
L
I
N
W
---------
G
F
D
L
P
T
K
K
I
E
E
E
T
G
I
Q
L
P
V
M
N
A
N
E
L
L
S
N
G
A
I
T
E
E
E
V
Q
R
V
E
N
E
H
K
N
A
I
R
N
A
R
------------
A
M
L
V
L
K
R
I
T
D
K
L
T
G
N
D
I
R
--
R
F
N
D
--
L
D
V
P
E
Q
V
D
K
L
I
Q
Q
A
T
S
V
E
N
L
C
Q
H
Y
I
G
W
C
P
F
W
23
HHSearch
37.20
15%
-9
- C2 -
-
5YZ0
-
?
A:
[664-2644]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
H
E
V
I
R
A
S
C
V
S
G
F
F
I
L
L
Q
Q
-----
Q
N
S
C
N
R
V
P
K
I
L
I
D
K
V
K
D
D
S
D
I
V
K
K
E
F
A
S
I
L
G
Q
L
V
C
T
L
H
G
M
F
Y
L
T
S
S
L
T
E
P
F
S
E
H
G
H
V
DLFCRNLKAT
S
Q
H
E
C
S
S
S
Q
L
-
K
A
S
V
--------------
C
K
P
F
L
F
L
L
K
K
K
I
P
S
P
V
K
L
A
F
I
D
N
L
H
--
H
L
C
K
H
L
D
F
R
E
D
E
T
D
V
K
A
V
L
G
T
L
L
-
N
L
---
M
E
D
P
D
K
D
V
R
V
A
F
S
G
N
I
K
H
I
L
E
------
S
L
D
S
E
D
G
F
-
I
K
E
L
F
V
L
R
M
K
E
A
Y
T
H
A
Q
I
S
R
N
-------
N
E
L
K
D
T
L
I
L
T
T
G
D
I
G
R
A
A
K
G
D
L
V
P
F
A
L
L
H
L
L
H
C
L
L
S
-------
K
---
S
A
S
V
S
G
A
A
Y
T
E
I
R
A
L
V
A
A
K
S
V
K
L
Q
S
F
F
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Q
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K
K
P
I
C
Q
F
L
V
E
S
-
L
H
S
S
Q
M
-
T
A
-------
L
P
N
---
T
P
C
Q
N
A
-----------
D
----------------------------------------------------
V
R
K
Q
D
V
A
H
Q
R
E
M
A
L
N
T
L
S
E
I
-
A
N
V
-
F
D
F
P
D
L
N
R
F
L
T
R
T
L
Q
V
L
L
P
D
L
A
A
K
A
S
P
A
A
S
A
L
I
R
T
L
-----
G
K
Q
L
N
V
N
R
---------
R
E
I
L
I
N
N
F
K
Y
I
F
S
H
L
V
C
S
C
S
K
D
E
L
E
R
---
A
L
H
Y
L
K
N
E
T
E
I
E
L
G
S
L
L
---------------------------------------
A
S
S
D
D
P
Y
Q
G
P
R
D
I
I
S
P
E
L
M
A
D
Y
L
Q
P
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L
L
G
I
L
A
F
F
N
M
Q
L
L
S
S
S
V
G
I
E
D
K
K
M
A
L
N
S
L
M
S
L
M
K
L
M
G
P
K
H
V
S
S
V
R
V
K
M
M
T
T
L
R
T
G
L
------
R
F
---
K
D
D
F
P
E
L
C
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
V
T
G
V
E
D
-
S
---
S
F
A
Y
------------------
G
L
L
M
E
L
T
R
A
Y
L
A
Y
------------------
A
-
D
N
S
R
A
Q
D
S
A
A
Y
A
I
Q
E
L
L
S
I
Y
D
C
R
E
---------
M
E
T
N
--------
G
P
G
H
Q
L
W
R
R
F
P
E
H
V
R
E
I
L
E
P
H
------------------------------------------
L
N
----------
T
------
R
Y
K
-
S
S
------
Q
--
K
S
T
D
W
S
G
V
--
K
K
P
--
I
Y
L
---
S
K
-
L
G
S
N
F
A
E
W
S
A
S
W
A
G
Y
L
I
T
K
V
R
H
D
L
A
S
K
I
F
T
-
C
C
S
--------
I
M
M
K
H
D
F
K
V
T
I
Y
L
L
P
H
I
L
V
Y
V
L
L
G
C
N
Q
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