@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : IMA3_HUMAN: (2018-10-05 )
MADNEKLDNQRLKNFKNKGRDLETMRRQRNEVVVELRKNKRDEHLLKRRNVPHEDICEDSDIDGDYRVQNTSLEAIVQNASSDNQGIQLSAVQAARKLLSSDRNPPIDDLIKSGILPILVHCLERDDNPSLQFEAAWALTNIASGTSEQTQAVVQSNAVPLFLRLLHSPHQNVCEQAVWALGNIIGDGPQCRDYVISLGVVKPLLSFISPSIPITFLRNVTWVMVNLCRHKDPPPPMETIQEILPALCVLIHHTDVNILVDTVWALSYLTDAGNEQIQMVIDSGIVPHLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDALSHFPALLTHPKEKINKEAVWFLSNITAGNQQQVQAVIDANLVPMIIHLLDKGDFGTQKEAAWAISNLTISGRKDQVAYLIQQNVIPPFCNLLTVKDAQVVQVVLDGLSNILKMAEDEAETIGNLIEECGGLEKIEQLQNHENEDIYKLAYEIIDQFFSSDDIDEDPSLVPEAIQGGTFGFNSSANVPTEGFQF
Atome Classification :
(21 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200......----.----210.----......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.....-.-.340.......350....-...360.......370.....-..380.......390.......400.........410.......420....---...430.......440..--.-------.-------...450.......460.......470.......480.......490.......500.......510.......520
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MAD
N
E
K
L
D
N
Q
R
L
K
N
F
K
NKGR
D
L
E
T
M
R
R
Q
R
N
E
V
V
V
E
L
R
KNK
R
D
E
H
L
L
K
RRNV
P
H
E
DICEDSDIDG
D
Y
R
V
QN
T
S
L
E
A
I
V
Q
NASSDNQ
G
I
Q
L
S
A
V
Q
A
A
R
K
L
L
SSDRNP
P
I
D
D
L
I
KSG
I
L
P
I
L
V
H
C
L
ERDDNPS
L
Q
F
E
A
A
W
A
L
TNIASGT
S
E
Q
T
Q
A
V
V
Q
SN
A
V
P
L
F
L
R
L
LHSP
H
Q
N
V
C
E
Q
A
V
W
A
L
G
N
IIGDGP
Q
C
R
D
Y
V
I
S
L
G
V
V
K
P
L
L
S
FI----S----PSI
P
----
I
T
F
L
R
N
V
T
W
V
M
V
N
L
C
RHKDPPP
P
M
E
T
I
Q
E
I
L
P
A
L
C
V
L
I
HHTD
V
N
I
L
V
D
T
V
W
A
L
S
Y
L
TDAGN
E
Q
I
Q
M
V
IDSG
I
V
P
H
L
V
P
L
LSHQ
E
V
K
V
Q
T
A
A
L
R
A
V
G
N
IVTGTDE
Q
T
Q
V
V
L
N
C
D
A
L
S
H
F
P
A
L
LTH-
P
-
K
E
KI
N
K
E
A
V
W
F
L
SNITAG-
N
Q
Q
Q
V
Q
A
V
I
DA
N
L
V
P
M
I
I
H
L
L-DKGDFGTQ
K
E
A
A
W
A
I
S
N
L
T
ISGR--K
D
Q
V
A
Y
L
I
Q
QNVIP
P
F
C
N
L
L
TVK
D
A
Q
---
V
V
Q
V
V
L
D
G
L
S
N
I
L
K
MAE
D
--
E
-------
A
-------
E
T
I
G
N
L
I
E
ECG
G
L
E
K
I
E
Q
L
QNHEN
E
D
I
Y
K
L
A
Y
E
I
I
D
Q
F
FSSDDIDEDPSL
V
P
E
A
IQGGTFGFNSSANVPTEGFQF
2
PsiBlast_PDB
93.72
100%
-190
- C1 -
-
4UAE
-
IMA3_HUMAN
A:
[5-421]
----------------------------------------------------------------------
T
S
L
E
A
I
V
Q
N
A
S
S
D
N
Q
G
I
Q
L
S
A
V
Q
A
A
R
K
L
L
S
S
D
R
N
P
P
I
D
D
L
I
K
S
G
I
L
P
I
L
V
H
C
L
E
R
D
D
N
P
S
L
Q
F
E
A
A
W
A
L
T
N
I
A
S
G
T
S
E
Q
T
Q
A
V
V
Q
S
N
A
V
P
L
F
L
R
L
L
H
S
P
H
Q
N
V
C
E
Q
A
V
W
A
L
G
N
I
I
G
D
G
P
Q
C
R
D
Y
V
I
S
L
G
V
V
K
P
L
L
S
F
I
----
S
----
P
S
I
P
----
I
T
F
L
R
N
V
T
W
V
M
V
N
L
C
R
H
K
D
P
P
P
P
M
E
T
I
Q
E
I
L
P
A
L
C
V
L
I
H
H
T
D
V
N
I
L
V
D
T
V
W
A
L
S
Y
L
T
D
A
G
N
E
Q
I
Q
M
V
I
D
S
G
I
V
P
H
L
V
P
L
L
S
H
Q
E
V
K
V
Q
T
A
A
L
R
A
V
G
N
I
V
T
G
T
D
E
Q
T
Q
V
V
L
N
C
D
A
L
S
H
F
P
A
L
L
T
H
-
P
-
K
E
K
I
N
K
E
A
V
W
F
L
S
N
I
T
A
G
-
N
Q
Q
Q
V
Q
A
V
I
D
A
N
L
V
P
M
I
I
H
L
L
-
D
K
G
D
F
G
T
Q
K
E
A
A
W
A
I
S
N
L
T
I
S
G
R
--
K
D
Q
V
A
Y
L
I
Q
Q
N
V
I
P
P
F
C
N
L
L
T
V
K
D
A
Q
---
V
V
Q
V
V
L
D
G
L
S
N
I
L
K
M
A
E
D
--
E
-------
A
-------
E
T
I
G
N
L
I
E
E
C
G
G
L
E
K
I
E
Q
L
Q
N
H
E
N
E
D
I
Y
K
L
A
Y
E
I
I
D
Q
F
F
S
S
----------------------------------
1
PsiBlast_PDB
93.51
100%
-193
- C1 -
-
5TBK
-
IMA3_HUMAN
A:
[71-487]
----------------------------------------------------------------------
T
S
L
E
A
I
V
Q
N
A
S
S
D
N
Q
G
I
Q
L
S
A
V
Q
A
A
R
K
L
L
S
S
D
R
N
P
P
I
D
D
L
I
K
S
G
I
L
P
I
L
V
H
C
L
E
R
D
D
N
P
S
L
Q
F
E
A
A
W
A
L
T
N
I
A
S
G
T
S
E
Q
T
Q
A
V
V
Q
S
N
A
V
P
L
F
L
R
L
L
H
S
P
H
Q
N
V
C
E
Q
A
V
W
A
L
G
N
I
I
G
D
G
P
Q
C
R
D
Y
V
I
S
L
G
V
V
K
P
L
L
S
F
I
----
S
----
P
S
I
P
----
I
T
F
L
R
N
V
T
W
V
M
V
N
L
C
R
H
K
D
P
P
P
P
M
E
T
I
Q
E
I
L
P
A
L
C
V
L
I
H
H
T
D
V
N
I
L
V
D
T
V
W
A
L
S
Y
L
T
D
A
G
N
E
Q
I
Q
M
V
I
D
S
G
I
V
P
H
L
V
P
L
L
S
H
Q
E
V
K
V
Q
T
A
A
L
R
A
V
G
N
I
V
T
G
T
D
E
Q
T
Q
V
V
L
N
C
D
A
L
S
H
F
P
A
L
L
T
H
-
P
-
K
E
K
I
N
K
E
A
V
W
F
L
S
N
I
T
A
G
-
N
Q
Q
Q
V
Q
A
V
I
D
A
N
L
V
P
M
I
I
H
L
L
-
D
K
G
D
F
G
T
Q
K
E
A
A
W
A
I
S
N
L
T
I
S
G
R
--
K
D
Q
V
A
Y
L
I
Q
Q
N
V
I
P
P
F
C
N
L
L
T
V
K
D
A
Q
---
V
V
Q
V
V
L
D
G
L
S
N
I
L
K
M
A
E
D
--
E
-------
A
-------
E
T
I
G
N
L
I
E
E
C
G
G
L
E
K
I
E
Q
L
Q
N
H
E
N
E
D
I
Y
K
L
A
Y
E
I
I
D
Q
F
F
S
S
----------------------------------
24
HHSearch
93.49
100%
-190
- C1 -
-
4UAE
-
IMA3_HUMAN
A:
[5-420]
----------------------------------------------------------------------
T
S
L
E
A
I
V
Q
N
A
S
S
D
N
Q
G
I
Q
L
S
A
V
Q
A
A
R
K
L
L
S
S
D
R
N
P
P
I
D
D
L
I
K
S
G
I
L
P
I
L
V
H
C
L
E
R
D
D
N
P
S
L
Q
F
E
A
A
W
A
L
T
N
I
A
S
G
T
S
E
Q
T
Q
A
V
V
Q
S
N
A
V
P
L
F
L
R
L
L
H
S
P
H
Q
N
V
C
E
Q
A
V
W
A
L
G
N
I
I
G
D
G
P
Q
C
R
D
Y
V
I
S
L
G
V
V
K
P
L
L
S
F
I
----
S
----
P
S
I
P
----
I
T
F
L
R
N
V
T
W
V
M
V
N
L
C
R
H
K
D
P
P
P
P
M
E
T
I
Q
E
I
L
P
A
L
C
V
L
I
H
H
T
D
V
N
I
L
V
D
T
V
W
A
L
S
Y
L
T
D
A
G
N
E
Q
I
Q
M
V
I
D
S
G
I
V
P
H
L
V
P
L
L
S
H
Q
E
V
K
V
Q
T
A
A
L
R
A
V
G
N
I
V
T
G
T
D
E
Q
T
Q
V
V
L
N
C
D
A
L
S
H
F
P
A
L
L
T
H
-
P
-
K
E
K
I
N
K
E
A
V
W
F
L
S
N
I
T
A
G
-
N
Q
Q
Q
V
Q
A
V
I
D
A
N
L
V
P
M
I
I
H
L
L
-
D
K
G
D
F
G
T
Q
K
E
A
A
W
A
I
S
N
L
T
I
S
G
R
--
K
D
Q
V
A
Y
L
I
Q
Q
N
V
I
P
P
F
C
N
L
L
T
V
K
D
A
Q
---
V
V
Q
V
V
L
D
G
L
S
N
I
L
K
M
A
E
D
--
E
-------
A
-------
E
T
I
G
N
L
I
E
E
C
G
G
L
E
K
I
E
Q
L
Q
N
H
E
N
E
D
I
Y
K
L
A
Y
E
I
I
D
Q
F
F
S
-----------------------------------
27
HHSearch
93.47
100%
-192
- C1 -
-
5XZX
-
IMA3_HUMAN
A:
[3-416]
-----------------------------------------------------------------------
S
L
E
A
I
V
Q
N
A
S
S
D
N
Q
G
I
Q
L
S
A
V
Q
A
A
R
K
L
L
S
S
D
R
N
P
P
I
D
D
L
I
K
S
G
I
L
P
I
L
V
H
C
L
E
R
D
D
N
P
S
L
Q
F
E
A
A
W
A
L
T
N
I
A
S
G
T
S
E
Q
T
Q
A
V
V
Q
S
N
A
V
P
L
F
L
R
L
L
H
S
P
H
Q
N
V
C
E
Q
A
V
W
A
L
G
N
I
I
G
D
G
P
Q
C
R
D
Y
V
I
S
L
G
V
V
K
P
L
L
S
F
I
----
S
----
P
S
I
P
----
I
T
F
L
R
N
V
T
W
V
M
V
N
L
C
R
H
K
D
P
P
P
P
M
E
T
I
Q
E
I
L
P
A
L
C
V
L
I
H
H
T
D
V
N
I
L
V
D
T
V
W
A
L
S
Y
L
T
D
A
G
N
E
Q
I
Q
M
V
I
D
S
G
I
V
P
H
L
V
P
L
L
S
H
Q
E
V
K
V
Q
T
A
A
L
R
A
V
G
N
I
V
T
G
T
D
E
Q
T
Q
V
V
L
N
C
D
A
L
S
H
F
P
A
L
L
T
H
-
P
-
K
E
K
I
N
K
E
A
V
W
F
L
S
N
I
T
A
G
-
N
Q
Q
Q
V
Q
A
V
I
D
A
N
L
V
P
M
I
I
H
L
L
-
D
K
G
D
F
G
T
Q
K
E
A
A
W
A
I
S
N
L
T
I
S
G
R
--
K
D
Q
V
A
Y
L
I
Q
Q
N
V
I
P
P
F
C
N
L
L
T
V
K
D
A
Q
---
V
V
Q
V
V
L
D
G
L
S
N
I
L
K
M
A
E
D
--
E
-------
A
-------
E
T
I
G
N
L
I
E
E
C
G
G
L
E
K
I
E
Q
L
Q
N
H
E
N
E
D
I
Y
K
L
A
Y
E
I
I
D
Q
F
F
------------------------------------
3
PsiBlast_PDB
93.47
100%
-192
- C1 -
-
5XZX
-
IMA3_HUMAN
A:
[3-416]
-----------------------------------------------------------------------
S
L
E
A
I
V
Q
N
A
S
S
D
N
Q
G
I
Q
L
S
A
V
Q
A
A
R
K
L
L
S
S
D
R
N
P
P
I
D
D
L
I
K
S
G
I
L
P
I
L
V
H
C
L
E
R
D
D
N
P
S
L
Q
F
E
A
A
W
A
L
T
N
I
A
S
G
T
S
E
Q
T
Q
A
V
V
Q
S
N
A
V
P
L
F
L
R
L
L
H
S
P
H
Q
N
V
C
E
Q
A
V
W
A
L
G
N
I
I
G
D
G
P
Q
C
R
D
Y
V
I
S
L
G
V
V
K
P
L
L
S
F
I
----
S
----
P
S
I
P
----
I
T
F
L
R
N
V
T
W
V
M
V
N
L
C
R
H
K
D
P
P
P
P
M
E
T
I
Q
E
I
L
P
A
L
C
V
L
I
H
H
T
D
V
N
I
L
V
D
T
V
W
A
L
S
Y
L
T
D
A
G
N
E
Q
I
Q
M
V
I
D
S
G
I
V
P
H
L
V
P
L
L
S
H
Q
E
V
K
V
Q
T
A
A
L
R
A
V
G
N
I
V
T
G
T
D
E
Q
T
Q
V
V
L
N
C
D
A
L
S
H
F
P
A
L
L
T
H
-
P
-
K
E
K
I
N
K
E
A
V
W
F
L
S
N
I
T
A
G
-
N
Q
Q
Q
V
Q
A
V
I
D
A
N
L
V
P
M
I
I
H
L
L
-
D
K
G
D
F
G
T
Q
K
E
A
A
W
A
I
S
N
L
T
I
S
G
R
--
K
D
Q
V
A
Y
L
I
Q
Q
N
V
I
P
P
F
C
N
L
L
T
V
K
D
A
Q
---
V
V
Q
V
V
L
D
G
L
S
N
I
L
K
M
A
E
D
--
E
-------
A
-------
E
T
I
G
N
L
I
E
E
C
G
G
L
E
K
I
E
Q
L
Q
N
H
E
N
E
D
I
Y
K
L
A
Y
E
I
I
D
Q
F
F
------------------------------------
33
HHSearch
73.05
54%
-71
- C1 -
-
3WPT
10
IMA1_HUMAN
B:
[3-422]
-----------------------------------------------------------------------
S
V
D
D
I
V
K
G
I
N
S
S
N
V
E
N
Q
L
Q
A
T
Q
A
A
R
K
L
L
S
R
E
K
Q
P
P
I
D
N
I
I
R
A
G
L
I
P
K
F
V
S
F
L
G
R
T
D
C
S
P
I
Q
F
E
S
A
W
A
L
T
N
I
A
S
G
T
S
E
Q
T
K
A
V
V
D
G
G
A
I
P
A
F
I
S
L
L
A
S
P
H
A
H
I
S
E
Q
A
V
W
A
L
G
N
I
A
G
D
G
S
V
F
R
D
L
V
I
K
Y
G
A
V
D
P
L
L
A
L
L
----
A
----
V
P
D
M
SSLA
C
G
Y
L
R
N
L
T
W
T
L
S
N
L
C
R
N
K
N
P
A
P
P
I
D
A
V
E
Q
I
L
P
T
L
V
R
L
L
H
H
D
D
P
E
V
L
A
D
T
C
W
A
I
S
Y
L
T
D
G
P
N
E
R
I
G
M
V
V
K
T
G
V
V
P
Q
L
V
K
L
L
G
A
S
E
L
P
I
V
T
P
A
L
R
A
I
G
N
I
V
T
G
T
D
E
Q
T
Q
V
V
I
D
A
G
A
L
A
V
F
P
S
L
L
T
N
-
P
-
K
T
N
I
Q
K
E
A
T
W
T
M
S
N
I
T
A
G
-
R
Q
D
Q
I
Q
Q
V
V
N
H
G
L
V
P
F
L
V
S
V
L
-
S
K
A
D
F
K
T
Q
K
E
A
V
W
A
V
T
N
Y
T
S
G
G
T
--
V
E
Q
I
V
Y
L
V
H
C
G
I
I
E
P
L
M
N
L
L
T
A
K
D
T
K
---
I
I
L
V
I
L
D
A
I
S
N
I
F
Q
A
A
E
K
--
L
GE-----
T
-------
E
K
L
S
I
M
I
E
E
C
G
G
L
D
K
I
E
A
L
Q
N
H
E
N
E
S
V
Y
K
A
S
L
S
L
I
E
K
Y
F
------------------------------------
31
HHSearch
72.98
50%
-133
- C1 -
-
4RXH
-
?
B:
[82-507]
-----------------------------------------------------------------------
D
L
P
K
M
V
E
G
V
F
S
S
E
I
D
K
Q
I
Q
A
T
T
K
F
R
K
L
L
S
K
E
R
N
P
P
I
E
E
V
I
K
T
G
V
V
G
R
F
V
E
F
L
R
-
S
P
H
T
L
V
Q
F
E
A
A
W
A
L
T
N
I
A
S
G
S
A
T
Q
T
Q
V
V
I
E
A
G
A
V
P
I
F
V
E
L
L
G
S
P
E
P
D
V
R
E
Q
A
V
W
A
L
G
N
I
A
G
D
S
P
Q
C
R
D
Y
V
L
S
C
G
A
L
R
P
L
L
T
L
L
----
G
----
D
S
R
K
----
L
S
M
L
R
N
A
T
W
T
L
S
N
F
C
R
G
K
T
P
Q
P
D
W
N
T
I
A
P
A
L
P
V
L
A
K
L
V
Y
S
L
D
D
E
V
L
I
D
A
C
W
A
I
S
Y
L
S
D
G
S
N
D
K
I
Q
A
V
I
E
A
G
I
P
R
R
L
V
E
L
L
M
H
A
S
T
S
V
Q
T
P
A
L
R
S
V
G
N
I
V
T
G
D
D
V
Q
T
Q
V
I
I
N
C
G
A
L
P
C
L
L
S
L
L
S
S
-
N
-
K
D
G
I
R
K
E
A
C
W
T
I
S
N
I
T
A
G
-
N
S
A
Q
I
Q
S
V
I
D
A
N
I
I
P
P
L
I
H
L
L
-
S
H
A
D
L
K
T
R
K
E
A
C
W
A
I
S
N
A
T
S
G
G
L
QK
P
D
Q
I
R
Y
L
V
A
Q
G
C
I
K
P
L
C
D
L
L
A
C
P
D
N
K
---
I
I
Q
V
A
L
D
G
L
E
N
I
L
K
V
G
E
L
--
D
KNAAS--
I
-------
N
R
Y
A
L
F
I
E
E
C
G
G
M
E
K
I
H
D
C
Q
T
N
A
N
E
E
I
Y
M
K
A
Y
N
I
I
E
K
Y
F
S
-----------------------------------
32
HHSearch
72.26
54%
-70
- C1 -
-
5H43
-
IMA1_HUMAN
A:
[7-428]
---------------------------------------------------------------------
N
W
S
V
D
D
I
V
K
G
I
N
S
S
N
V
E
N
Q
L
Q
A
T
Q
A
A
R
K
L
L
S
R
E
K
Q
P
P
I
D
N
I
I
R
A
G
L
I
P
K
F
V
S
F
L
G
R
T
D
C
S
P
I
Q
F
E
S
A
W
A
L
T
N
I
A
S
G
T
S
E
Q
T
K
A
V
V
D
G
G
A
I
P
A
F
I
S
L
L
A
S
P
H
A
H
I
S
E
Q
A
V
W
A
L
G
N
I
A
G
D
G
S
V
F
R
D
L
V
I
K
Y
G
A
V
D
P
L
L
A
L
L
----
A
----
V
P
D
M
SSLA
C
G
Y
L
R
N
L
T
W
T
L
S
N
L
C
R
N
K
N
P
A
P
P
I
D
A
V
E
Q
I
L
P
T
L
V
R
L
L
H
H
D
D
P
E
V
L
A
D
T
C
W
A
I
S
Y
L
T
D
G
P
N
E
R
I
G
M
V
V
K
T
G
V
V
P
Q
L
V
K
L
L
G
A
S
E
L
P
I
V
T
P
A
L
R
A
I
G
N
I
V
T
G
T
D
E
Q
T
Q
V
V
I
D
A
G
A
L
A
V
F
P
S
L
L
T
N
-
P
-
K
T
N
I
Q
K
E
A
T
W
T
M
S
N
I
T
A
G
-
R
Q
D
Q
I
Q
Q
V
V
N
H
G
L
V
P
F
L
V
S
V
L
-
S
K
A
D
F
K
T
Q
K
E
A
V
W
A
V
T
N
Y
T
S
G
G
T
--
V
E
Q
I
V
Y
L
V
H
C
G
I
I
E
P
L
M
N
L
L
T
A
K
D
T
K
---
I
I
L
V
I
L
D
A
I
S
N
I
F
Q
A
A
E
K
--
L
GE-----
T
-------
E
K
L
S
I
M
I
E
E
C
G
G
L
D
K
I
E
A
L
Q
N
H
E
N
E
S
V
Y
K
A
S
L
S
L
I
E
K
Y
F
------------------------------------
34
HHSearch
71.75
49%
-120
- C1 -
-
1EE4
-
IMA1_YEAST
B:
[2-423]
-----------------------------------------------------------------------
E
L
P
Q
M
T
Q
Q
L
N
S
D
D
M
Q
E
Q
L
S
A
T
V
K
F
R
Q
I
L
S
R
E
H
R
P
P
I
D
V
V
I
Q
A
G
V
V
P
R
L
V
E
F
M
R
E
N
Q
P
E
M
L
Q
L
E
A
A
W
A
L
T
N
I
A
S
G
T
S
A
Q
T
K
V
V
V
D
A
D
A
V
P
L
F
I
Q
L
L
Y
T
G
S
V
E
V
K
E
Q
A
I
W
A
L
G
N
V
A
G
D
S
T
D
Y
R
D
Y
V
L
Q
C
N
A
M
E
P
I
L
G
L
F
----
N
-----
S
N
K
----
P
S
L
I
R
T
A
T
W
T
L
S
N
L
C
R
G
K
K
P
Q
P
D
W
S
V
V
S
Q
A
L
P
T
L
A
K
L
I
Y
S
M
D
T
E
T
L
V
D
A
C
W
A
I
S
Y
L
S
D
G
P
Q
E
A
I
Q
A
V
I
D
V
R
I
P
K
R
L
V
E
L
L
S
H
E
S
T
L
V
Q
T
P
A
L
R
A
V
G
N
I
V
T
G
N
D
L
Q
T
Q
V
V
I
N
A
G
V
L
P
A
L
R
L
L
L
S
S
-
P
-
K
E
N
I
K
K
E
A
C
W
T
I
S
N
I
T
A
G
-
N
T
E
Q
I
Q
A
V
I
D
A
N
L
I
P
P
L
V
K
L
L
-
E
V
A
E
D
K
T
K
K
E
A
C
W
A
I
S
N
A
S
S
G
G
L
QR
P
D
I
I
R
Y
L
V
S
Q
G
C
I
K
P
L
C
D
L
L
E
I
A
D
N
R
---
I
I
E
V
T
L
D
A
L
E
N
I
L
K
M
G
E
A
--
D
KEARGLN
I
-------
N
E
N
A
D
F
I
E
K
A
G
G
M
E
K
I
F
N
C
Q
Q
N
E
N
D
K
I
Y
E
K
A
Y
K
I
I
E
T
Y
F
------------------------------------
21
HHSearch
69.90
47%
-94
- C1 -
-
1WA5
-
IMA1_YEAST
B:
[12-513]
-----
F
V
P
E
Y
R
R
T
----------
E
L
R
R
R
R
D
T
Q
Q
V
E
L
R
K
A
K
R
D
E
A
L
A
K
R
R
N
F
-------------------
Q
E
L
P
Q
M
T
Q
Q
L
N
S
D
D
M
Q
E
Q
L
S
A
T
V
K
F
R
Q
I
L
S
R
E
H
R
P
P
I
D
V
V
I
Q
A
G
V
V
P
R
L
V
E
F
M
R
E
N
Q
P
E
M
L
Q
L
E
A
A
W
A
L
T
N
I
A
S
G
T
S
A
Q
T
K
V
V
V
D
A
D
A
V
P
L
F
I
Q
L
L
Y
T
G
S
V
E
V
K
E
Q
A
I
W
A
L
G
N
V
A
G
D
S
T
D
Y
R
D
Y
V
L
Q
C
N
A
M
E
P
I
L
G
L
F
----
N
-----
S
N
K
----
P
S
L
I
R
T
A
T
W
T
L
S
N
L
C
R
G
K
K
P
Q
P
D
W
S
V
V
S
Q
A
L
P
T
L
A
K
L
I
Y
S
M
D
T
E
T
L
V
D
A
C
W
A
I
S
Y
L
S
D
G
P
Q
E
A
I
Q
A
V
I
D
V
R
I
P
K
R
L
V
E
L
L
S
H
E
S
T
L
V
Q
T
P
A
L
R
A
V
G
N
I
V
T
G
N
D
L
Q
T
Q
V
V
I
N
A
G
V
L
P
A
L
R
L
L
L
S
S
-
P
-
K
E
N
I
K
K
E
A
C
W
T
I
S
N
I
T
A
G
-
N
T
E
Q
I
Q
A
V
I
D
A
N
L
I
P
P
L
V
K
L
L
-
E
V
A
E
Y
K
T
K
K
E
A
C
W
A
I
S
N
A
S
S
G
G
L
QR
P
D
I
I
R
Y
L
V
S
Q
G
C
I
K
P
L
C
D
L
L
E
I
A
D
N
R
---
I
I
E
V
T
L
D
A
L
E
N
I
L
K
M
G
E
A
--
D
K
E
A
RGLN
I
-------
N
E
N
A
D
F
I
E
K
A
G
G
M
E
K
I
F
N
C
Q
Q
N
E
N
D
K
I
Y
E
K
A
Y
K
I
I
E
T
Y
F
G
E
E
E
--------------------------------
42
Fugue
69.59
53%
-72
* C1 *
-
1IAL
-
IMA1_MOUSE
A:
[70-496]
----------------------------------------------------------------
N
Q
G
T
V
N
W
S
V
E
D
I
V
K
G
I
N
S
N
N
L
E
S
Q
L
Q
A
T
Q
A
A
R
K
L
L
S
R
E
K
Q
P
P
I
D
N
I
I
R
A
G
L
I
P
K
F
V
S
F
L
G
K
T
D
C
S
P
I
Q
F
E
S
A
W
A
L
T
N
I
A
S
G
T
S
E
Q
T
K
A
V
V
D
G
G
A
I
P
A
F
I
S
L
L
A
S
P
H
A
H
I
S
E
Q
A
V
W
A
L
G
N
I
A
G
D
G
S
A
F
R
D
L
V
I
K
H
G
A
I
D
P
L
L
A
L
L
AVPD
L
----
S
T
L
A
----
C
G
Y
L
R
N
L
T
W
T
L
S
N
L
C
R
N
K
N
P
A
P
P
L
D
A
V
E
Q
I
L
P
T
L
V
R
L
L
H
H
N
D
P
E
V
L
A
D
S
C
W
A
I
S
Y
L
T
D
G
P
N
E
R
I
E
M
V
V
K
K
G
V
V
P
Q
L
V
K
L
L
G
A
T
E
L
P
I
V
T
P
A
L
R
A
I
G
N
I
V
T
G
T
D
E
Q
T
Q
K
V
I
D
A
G
A
L
A
V
F
P
S
L
L
T
N
P--
K
T
N
I
Q
K
E
A
T
W
T
M
S
N
I
T
A
G
R-
Q
D
Q
I
Q
Q
V
V
N
H
G
L
V
P
F
L
V
G
V
L
S
-
K
A
D
F
K
T
Q
K
E
A
A
W
A
I
T
N
Y
T
S
G
G
-T-
V
E
Q
I
V
Y
L
V
H
C
G
I
I
E
P
L
M
N
L
L
S
A
K
---D
T
K
I
I
Q
V
I
L
D
A
I
S
N
I
F
Q
A
A
E
K
--
L
-------
G
E
T
-----
E
K
L
S
I
M
I
E
E
C
G
G
L
D
K
I
E
A
L
Q
R
H
E
N
E
S
V
Y
K
A
S
L
N
L
I
E
K
Y
F
------------------------------------
26
HHSearch
69.37
48%
-122
- C1 -
-
4BQK
5
IMA1A_ORYSJ
A:
[2-424]
----------------------------------------------------------------------
S
S
L
P
A
M
I
G
G
V
Y
S
D
D
N
N
L
Q
L
E
A
T
T
Q
F
R
K
L
L
S
I
E
R
S
P
P
I
E
E
V
I
Q
S
G
V
V
P
R
F
V
Q
F
L
T
R
E
D
F
P
Q
L
Q
F
E
A
A
W
A
L
T
N
I
A
S
G
T
S
E
N
T
K
V
V
I
D
H
G
A
V
P
I
F
V
K
L
L
G
S
S
S
D
D
V
R
E
Q
A
V
W
A
L
G
N
V
A
G
D
S
P
K
C
R
D
L
V
L
A
N
G
A
L
L
P
L
L
A
Q
L
----
N
----
E
H
T
K
----
L
S
M
L
R
N
A
T
W
T
L
S
N
F
C
R
G
K
P
Q
P
-
S
F
E
Q
T
R
P
A
L
P
A
L
A
R
L
I
H
S
N
D
E
E
V
L
T
D
A
C
W
A
L
S
Y
L
S
D
G
T
N
D
K
I
Q
A
V
I
E
A
G
V
C
P
R
L
V
E
L
L
L
H
P
S
P
S
V
L
I
P
A
L
R
T
V
G
N
I
V
T
G
D
D
A
Q
T
Q
C
I
I
D
H
Q
A
L
P
C
L
L
S
L
L
T
Q
-
N
L
K
K
S
I
K
K
E
A
C
W
T
I
S
N
I
T
A
G
-
N
K
D
Q
I
Q
A
V
I
N
A
G
I
I
G
P
L
V
N
L
L
-
Q
T
A
E
F
D
I
K
K
E
A
A
W
A
I
S
N
A
T
S
G
G
S
--
H
D
Q
I
K
Y
L
V
S
E
G
C
I
K
P
L
C
D
L
L
I
C
P
D
I
R
---
I
V
T
V
C
L
E
G
L
E
N
I
L
K
V
G
E
T
--
D
-------
K
T
L
A
AGDV
N
V
F
S
Q
M
I
D
E
A
E
G
L
E
K
I
E
N
L
Q
S
H
D
N
N
E
I
Y
E
K
A
V
K
I
L
E
A
Y
W
M
-----------------------------------
16
PsiBlast_PDB
68.53
49%
-64
- C1 -
-
5SVZ
-
?
A:
[53-478]
------------------------------------------------------------------
G
T
V
N
W
S
V
E
D
I
V
K
G
I
N
S
N
N
L
E
S
Q
L
Q
A
T
Q
A
A
R
K
L
L
S
R
E
K
Q
P
P
I
D
N
I
I
R
A
G
L
I
P
K
F
V
S
F
L
G
K
T
D
C
S
P
I
Q
F
E
S
A
W
A
L
T
N
I
A
S
G
T
S
E
Q
T
K
A
V
V
D
G
G
A
I
P
A
F
I
S
L
L
A
S
P
H
A
H
I
S
E
Q
A
V
W
A
L
G
N
I
A
G
D
G
S
A
F
R
D
L
V
I
K
H
G
A
I
D
P
L
L
A
L
L
----
A
VPDL
S
T
L
A
----
C
G
Y
L
R
N
L
T
W
T
L
S
N
L
C
R
N
K
N
P
A
P
P
L
D
A
V
E
Q
I
L
P
T
L
V
R
L
L
H
H
N
D
P
E
V
L
A
D
S
C
W
A
I
S
Y
L
T
D
G
P
N
E
R
I
E
M
V
V
K
K
G
V
V
P
Q
L
V
K
L
L
G
A
T
E
L
P
I
V
T
P
A
L
R
A
I
G
N
I
V
T
G
T
D
E
Q
T
Q
K
V
I
D
A
G
A
L
A
V
F
P
S
L
L
T
N
-
P
-
K
T
N
I
Q
K
E
A
T
W
T
M
S
N
I
T
A
G
-
R
Q
D
Q
I
Q
Q
V
V
N
H
G
L
V
P
F
L
V
G
V
L
-
S
K
A
D
F
K
T
Q
K
E
A
A
W
A
I
T
N
Y
T
S
G
G
T
--
V
E
Q
I
V
Y
L
V
H
C
G
I
I
E
P
L
M
N
L
L
S
A
K
D
T
K
---
I
I
Q
V
I
L
D
A
I
S
N
I
F
Q
A
A
E
K
L
G
E
-------
T
-------
E
K
L
S
I
M
I
E
E
C
G
G
L
D
K
I
E
A
L
Q
R
H
E
N
E
S
V
Y
K
A
S
L
N
L
I
E
K
Y
F
S
-----------------------------------
7
PsiBlast_PDB
68.42
49%
-63
- C1 -
-
3UKW
1
?
B:
[53-478]
------------------------------------------------------------------
G
T
V
N
W
S
V
E
D
I
V
K
G
I
N
S
N
N
L
E
S
Q
L
Q
A
T
Q
A
A
R
K
L
L
S
R
E
K
Q
P
P
I
D
N
I
I
R
A
G
L
I
P
K
F
V
S
F
L
G
K
T
D
C
S
P
I
Q
F
E
S
A
W
A
L
T
N
I
A
S
G
T
S
E
Q
T
K
A
V
V
D
G
G
A
I
P
A
F
I
S
L
L
A
S
P
H
A
H
I
S
E
Q
A
V
W
A
L
G
N
I
A
G
D
G
S
A
F
R
D
L
V
I
K
H
G
A
I
D
P
L
L
A
L
L
----
A
VPDL
S
T
L
A
----
C
G
Y
L
R
N
L
T
W
T
L
S
N
L
C
R
N
K
N
P
A
P
P
L
D
A
V
E
Q
I
L
P
T
L
V
R
L
L
H
H
N
D
P
E
V
L
A
D
S
C
W
A
I
S
Y
L
T
D
G
P
N
E
R
I
E
M
V
V
K
K
G
V
V
P
Q
L
V
K
L
L
G
A
T
E
L
P
I
V
T
P
A
L
R
A
I
G
N
I
V
T
G
T
D
E
Q
T
Q
K
V
I
D
A
G
A
L
A
V
F
P
S
L
L
T
N
-
P
-
K
T
N
I
Q
K
E
A
T
W
T
M
S
N
I
T
A
G
-
R
Q
D
Q
I
Q
Q
V
V
N
H
G
L
V
P
F
L
V
G
V
L
-
S
K
A
D
F
K
T
Q
K
E
A
A
W
A
I
T
N
Y
T
S
G
G
T
--
V
E
Q
I
V
Y
L
V
H
C
G
I
I
E
P
L
M
N
L
L
S
A
K
D
T
K
---
I
I
Q
V
I
L
D
A
I
S
N
I
F
Q
A
A
E
K
LG
E
-------
T
-------
E
K
L
S
I
M
I
E
E
C
G
G
L
D
K
I
E
A
L
Q
R
H
E
N
E
S
V
Y
K
A
S
L
N
L
I
E
K
Y
F
S
-----------------------------------
17
PsiBlast_PDB
68.33
49%
-61
- C1 -
-
4HTV
-
IMA1_MOUSE
A:
[52-478]
-----------------------------------------------------------------
Q
G
T
V
N
W
S
V
E
D
I
V
K
G
I
N
S
N
N
L
E
S
Q
L
Q
A
T
Q
A
A
R
K
L
L
S
R
E
K
Q
P
P
I
D
N
I
I
R
A
G
L
I
P
K
F
V
S
F
L
G
K
T
D
C
S
P
I
Q
F
E
S
A
W
A
L
T
N
I
A
S
G
T
S
E
Q
T
K
A
V
V
D
G
G
A
I
P
A
F
I
S
L
L
A
S
P
H
A
H
I
S
E
Q
A
V
W
A
L
G
N
I
A
G
D
G
S
A
F
R
D
L
V
I
K
H
G
A
I
D
P
L
L
A
L
L
----
A
VPDL
S
T
L
A
----
C
G
Y
L
R
N
L
T
W
T
L
S
N
L
C
R
N
K
N
P
A
P
P
L
D
A
V
E
Q
I
L
P
T
L
V
R
L
L
H
H
N
D
P
E
V
L
A
D
S
C
W
A
I
S
Y
L
T
D
G
P
N
E
R
I
E
M
V
V
K
K
G
V
V
P
Q
L
V
K
L
L
G
A
T
E
L
P
I
V
T
P
A
L
R
A
I
G
N
I
V
T
G
T
D
E
Q
T
Q
K
V
I
D
A
G
A
L
A
V
F
P
S
L
L
T
N
-
P
-
K
T
N
I
Q
K
E
A
T
W
T
M
S
N
I
T
A
G
-
R
Q
D
Q
I
Q
Q
V
V
N
H
G
L
V
P
F
L
V
G
V
L
-
S
K
A
D
F
K
T
Q
K
E
A
A
W
A
I
T
N
Y
T
S
G
G
T
--
V
E
Q
I
V
Y
L
V
H
C
G
I
I
E
P
L
M
N
L
L
S
A
K
D
T
K
---
I
I
Q
V
I
L
D
A
I
S
N
I
F
Q
A
A
E
K
L
G
E
-------
T
-------
E
K
L
S
I
M
I
E
E
C
G
G
L
D
K
I
E
A
L
Q
R
H
E
N
E
S
V
Y
K
A
S
L
N
L
I
E
K
Y
F
S
-----------------------------------
14
PsiBlast_PDB
68.28
49%
-59
- C1 -
-
5KLR
-
?
B:
[53-478]
------------------------------------------------------------------
G
T
V
N
W
S
V
E
D
I
V
K
G
I
N
S
N
N
L
E
S
Q
L
Q
A
T
Q
A
A
R
K
L
L
S
R
E
K
Q
P
P
I
D
N
I
I
R
A
G
L
I
P
K
F
V
S
F
L
G
K
T
D
C
S
P
I
Q
F
E
S
A
W
A
L
T
N
I
A
S
G
T
S
E
Q
T
K
A
V
V
D
G
G
A
I
P
A
F
I
S
L
L
A
S
P
H
A
H
I
S
E
Q
A
V
W
A
L
G
N
I
A
G
D
G
S
A
F
R
D
L
V
I
K
H
G
A
I
D
P
L
L
A
L
L
----
A
VPDL
S
T
L
A
----
C
G
Y
L
R
N
L
T
W
T
L
S
N
L
C
R
N
K
N
P
A
P
P
L
D
A
V
E
Q
I
L
P
T
L
V
R
L
L
H
H
N
D
P
E
V
L
A
D
S
C
W
A
I
S
Y
L
T
D
G
P
N
E
R
I
E
M
V
V
K
K
G
V
V
P
Q
L
V
K
L
L
G
A
T
E
L
P
I
V
T
P
A
L
R
A
I
G
N
I
V
T
G
T
D
E
Q
T
Q
K
V
I
D
A
G
A
L
A
V
F
P
-
L
L
T
N
-
P
-
K
T
N
I
Q
K
E
A
T
W
T
M
S
N
I
T
A
G
-
R
Q
D
Q
I
Q
Q
V
V
N
H
G
L
V
P
F
L
V
G
V
L
-
S
K
A
D
F
K
T
Q
K
E
A
A
W
A
I
T
N
Y
T
S
G
G
T
--
V
E
Q
I
V
Y
L
V
H
C
G
I
I
E
P
L
M
N
L
L
S
A
K
D
T
K
---
I
I
Q
V
I
L
D
A
I
S
N
I
F
Q
A
A
E
K
L
G
E
-------
T
-------
E
K
L
S
I
M
I
E
E
C
G
G
L
D
K
I
E
A
L
Q
R
H
E
N
E
S
V
Y
K
A
S
L
N
L
I
E
K
Y
F
S
-----------------------------------
13
PsiBlast_PDB
68.24
49%
-60
- C1 -
-
5FC8
-
?
E:
[52-478]
-----------------------------------------------------------------
Q
G
T
V
N
W
S
V
E
D
I
V
K
G
I
N
S
N
N
L
E
S
Q
L
Q
A
T
Q
A
A
R
K
L
L
S
R
E
K
Q
P
P
I
D
N
I
I
R
A
G
L
I
P
K
F
V
S
F
L
G
K
T
D
C
S
P
I
Q
F
E
S
A
W
A
L
T
N
I
A
S
G
T
S
E
Q
T
K
A
V
V
D
G
G
A
I
P
A
F
I
S
L
L
A
S
P
H
A
H
I
S
E
Q
A
V
W
A
L
G
N
I
A
G
D
G
S
A
F
R
D
L
V
I
K
H
G
A
I
D
P
L
L
A
L
L
----
A
VPDL
S
T
L
A
----
C
G
Y
L
R
N
L
T
W
T
L
S
N
L
C
R
N
K
N
P
A
P
P
L
D
A
V
E
Q
I
L
P
T
L
V
R
L
L
H
H
N
D
P
E
V
L
A
D
S
C
W
A
I
S
Y
L
T
D
G
P
N
E
R
I
E
M
V
V
K
K
G
V
V
P
Q
L
V
K
L
L
G
A
T
E
L
P
I
V
T
P
A
L
R
A
I
G
N
I
V
T
G
T
D
E
Q
T
Q
K
V
I
D
A
G
A
L
A
V
F
P
S
L
L
T
N
-
P
-
K
T
N
I
Q
K
E
A
T
W
T
M
S
N
I
T
A
G
-
R
Q
D
Q
I
Q
Q
V
V
N
H
G
L
V
P
F
L
V
G
V
L
-
S
K
A
D
F
K
T
Q
K
E
A
A
W
A
I
T
N
Y
T
S
G
G
T
--
V
E
Q
I
V
Y
L
V
H
C
G
I
I
E
P
L
M
N
L
L
S
A
K
D
T
K
---
I
I
Q
V
I
L
D
A
I
S
N
I
F
Q
A
A
E
K
LG
E
-------
T
-------
E
K
L
S
I
M
I
E
E
C
G
G
L
D
K
I
E
A
L
Q
R
H
E
N
E
S
V
Y
K
A
S
L
N
L
I
E
K
Y
F
S
-----------------------------------
18
PsiBlast_PDB
68.20
49%
-64
- C1 -
-
4MZ5
-
?
E:
[52-478]
-----------------------------------------------------------------
Q
G
T
V
N
W
S
V
E
D
I
V
K
G
I
N
S
N
N
L
E
S
Q
L
Q
A
T
Q
A
A
R
K
L
L
S
R
E
K
Q
P
P
I
D
N
I
I
R
A
G
L
I
P
K
F
V
S
F
L
G
K
T
D
C
S
P
I
Q
F
E
S
A
W
A
L
T
N
I
A
S
G
T
S
E
Q
T
K
A
V
V
D
G
G
A
I
P
A
F
I
S
L
L
A
S
P
H
A
H
I
S
E
Q
A
V
W
A
L
G
N
I
A
G
D
G
S
A
F
R
D
L
V
I
K
H
G
A
I
D
P
L
L
A
L
L
----
A
VPDL
S
T
L
A
----
C
G
Y
L
R
N
L
T
W
T
L
S
N
L
C
R
N
K
N
P
A
P
P
L
D
A
V
E
Q
I
L
P
T
L
V
R
L
L
H
H
N
D
P
E
V
L
A
D
S
C
W
A
I
S
Y
L
T
D
G
P
N
E
R
I
E
M
V
V
K
K
G
V
V
P
Q
L
V
K
L
L
G
A
T
E
L
P
I
V
T
P
A
L
R
A
I
G
N
I
V
T
G
T
D
E
Q
T
Q
K
V
I
D
A
G
A
L
A
V
F
P
S
L
L
T
N
-
P
-
K
T
N
I
Q
K
E
A
T
W
T
M
S
N
I
T
A
G
-
R
Q
D
Q
I
Q
Q
V
V
N
H
G
L
V
P
F
L
V
G
V
L
-
S
K
A
D
F
K
T
Q
K
E
A
A
W
A
I
T
N
Y
T
S
G
G
T
--
V
E
Q
I
V
Y
L
V
H
C
G
I
I
E
P
L
M
N
L
L
S
A
K
D
T
K
---
I
I
Q
V
I
L
D
A
I
S
N
I
F
Q
A
A
E
K
LG
E
-------
T
-------
E
K
L
S
I
M
I
E
E
C
G
G
L
D
K
I
E
A
L
Q
R
H
E
N
E
S
V
Y
K
A
S
L
N
L
I
E
K
Y
F
S
-----------------------------------
12
PsiBlast_PDB
68.14
49%
-59
- C1 -
-
3UL1
-
IMA1_MOUSE
B:
[53-478]
------------------------------------------------------------------
G
T
V
N
W
S
V
E
D
I
V
K
G
I
N
S
N
N
L
E
S
Q
L
Q
A
T
Q
A
A
R
K
L
L
S
R
E
K
Q
P
P
I
D
N
I
I
R
A
G
L
I
P
K
F
V
S
F
L
G
K
T
D
C
S
P
I
Q
F
E
S
A
W
A
L
T
N
I
A
S
G
T
S
E
Q
T
K
A
V
V
D
G
G
A
I
P
A
F
I
S
L
L
A
S
P
H
A
H
I
S
E
Q
A
V
W
A
L
G
N
I
A
G
D
G
S
A
F
R
D
L
V
I
K
H
G
A
I
D
P
L
L
A
L
L
----
A
VPDL
S
T
L
A
----
C
G
Y
L
R
N
L
T
W
T
L
S
N
L
C
R
N
K
N
P
A
P
P
L
D
A
V
E
Q
I
L
P
T
L
V
R
L
L
H
H
N
D
P
E
V
L
A
D
S
C
W
A
I
S
Y
L
T
D
G
P
N
E
R
I
E
M
V
V
K
K
G
V
V
P
Q
L
V
K
L
L
G
A
T
E
L
P
I
V
T
P
A
L
R
A
I
G
N
I
V
T
G
T
D
E
Q
T
Q
K
V
I
D
A
G
A
L
A
V
F
P
-
L
L
T
N
-
P
-
K
T
N
I
Q
K
E
A
T
W
T
M
S
N
I
T
A
G
-
R
Q
D
Q
I
Q
Q
V
V
N
H
G
L
V
P
F
L
V
G
V
L
-
S
K
A
D
F
K
T
Q
K
E
A
A
W
A
I
T
N
Y
T
S
G
G
T
--
V
E
Q
I
V
Y
L
V
H
C
G
I
I
E
P
L
M
N
L
L
S
A
K
D
T
K
---
I
I
Q
V
I
L
D
A
I
S
N
I
F
Q
A
A
E
K
L
G
E
-------
T
-------
E
K
L
S
I
M
I
E
E
C
G
G
L
D
K
I
E
A
L
Q
R
H
E
N
E
S
V
Y
K
A
S
L
N
L
I
E
K
Y
F
S
-----------------------------------
11
PsiBlast_PDB
68.10
49%
-63
- C1 -
-
3UL0
-
IMA1_MOUSE
B:
[52-477]
-----------------------------------------------------------------
Q
G
T
V
N
W
S
V
E
D
I
V
K
G
I
N
S
N
N
L
E
S
Q
L
Q
A
T
Q
A
A
R
K
L
L
S
R
E
K
Q
P
P
I
D
N
I
I
R
A
G
L
I
P
K
F
V
S
F
L
G
K
T
D
C
S
P
I
Q
F
E
S
A
W
A
L
T
N
I
A
S
G
T
S
E
Q
T
K
A
V
V
D
G
G
A
I
P
A
F
I
S
L
L
A
S
P
H
A
H
I
S
E
Q
A
V
W
A
L
G
N
I
A
G
D
G
S
A
F
R
D
L
V
I
K
H
G
A
I
D
P
L
L
A
L
L
----
A
VPDL
S
T
L
A
----
C
G
Y
L
R
N
L
T
W
T
L
S
N
L
C
R
N
K
N
P
A
P
P
L
D
A
V
E
Q
I
L
P
T
L
V
R
L
L
H
H
N
D
P
E
V
L
A
D
S
C
W
A
I
S
Y
L
T
D
G
P
N
E
R
I
E
M
V
V
K
K
G
V
V
P
Q
L
V
K
L
L
G
A
T
E
L
P
I
V
T
P
A
L
R
A
I
G
N
I
V
T
G
T
D
E
Q
T
Q
K
V
I
D
A
G
A
L
A
V
F
P
S
L
L
T
N
-
P
-
K
T
N
I
Q
K
E
A
T
W
T
M
S
N
I
T
A
G
-
R
Q
D
Q
I
Q
Q
V
V
N
H
G
L
V
P
F
L
V
G
V
L
-
S
K
A
D
F
K
T
Q
K
E
A
A
W
A
I
T
N
Y
T
S
G
G
T
--
V
E
Q
I
V
Y
L
V
H
C
G
I
I
E
P
L
M
N
L
L
S
A
K
D
T
K
---
I
I
Q
V
I
L
D
A
I
S
N
I
F
Q
A
A
E
K
LG
E
-------
T
-------
E
K
L
S
I
M
I
E
E
C
G
G
L
D
K
I
E
A
L
Q
R
H
E
N
E
S
V
Y
K
A
S
L
N
L
I
E
K
Y
F
------------------------------------
20
PsiBlast_PDB
67.53
49%
-63
- C1 -
-
5UMZ
4
?
B:
[53-478]
------------------------------------------------------------------
G
T
V
N
W
S
V
E
D
I
V
K
G
I
N
S
N
N
L
E
S
Q
L
Q
A
T
Q
A
A
R
K
L
L
S
R
E
K
Q
P
P
I
D
N
I
I
R
A
G
L
I
P
K
F
V
S
F
L
G
K
T
D
C
S
P
I
Q
F
E
S
A
W
A
L
T
N
I
A
S
G
T
S
E
Q
T
K
A
V
V
D
G
G
A
I
P
A
F
I
S
L
L
A
S
P
H
A
H
I
S
E
Q
A
V
W
A
L
G
N
I
A
G
D
G
S
A
F
R
D
L
V
I
K
H
G
A
I
D
P
L
L
A
L
L
----
A
VPDL
S
T
L
A
----
C
G
Y
L
R
N
L
T
W
T
L
S
N
L
C
R
N
K
N
P
A
P
P
L
D
A
V
E
Q
I
L
P
T
L
V
R
L
L
H
H
N
D
P
E
V
L
A
D
S
C
W
A
I
S
Y
L
T
D
G
P
N
E
R
I
E
M
V
V
K
K
G
V
V
P
Q
L
V
K
L
L
G
A
T
E
L
P
I
V
T
P
A
L
R
A
I
G
N
I
V
T
G
T
D
E
Q
T
Q
K
V
I
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A
G
A
L
A
V
F
P
S
L
L
T
N
-
P
-
K
T
N
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Q
K
E
A
T
W
T
M
S
N
I
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A
G
-
R
Q
D
Q
I
Q
Q
V
V
N
H
G
L
V
P
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L
V
G
V
L
-
S
K
A
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F
K
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Q
K
E
A
A
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A
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T
N
Y
T
S
G
G
T
--
V
E
Q
I
V
Y
L
V
H
C
G
I
I
E
P
L
M
N
L
L
S
A
K
D
T
K
---
I
I
Q
V
I
L
D
A
I
S
N
I
F
Q
A
A
E
K
LG
E
-------
T
-------
E
K
L
S
I
M
I
E
E
C
G
G
L
D
K
I
E
A
L
Q
R
H
E
N
E
S
V
Y
K
A
S
L
N
L
I
E
K
Y
F
S
-----------------------------------