@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : P73_HUMAN: (2018-10-06 )
MAQSTATSPDGGTTFEHLWSSLEPDSTYFDLPQSSRGNNEVVGGTDSSMDVFHLEGMTTSVMAQFNLLSSTMDQMSSRAASASPYTPEHAASVPTHSPYAQPSSTFDTMSPAPVIPSNTDYPGPHHFEVTFQQSSTAKSATWTYSPLLKKLYCQIAKTCPIQIKVSTPPPPGTAIRAMPVYKKAEHVTDVVKRCPNHELGRDFNEGQSAPASHLIRVEGNNLSQYVDDPVTGRQSVVVPYEPPQVGTEFTTILYNFMCNSSCVGGMNRRPILIIITLEMRDGQVLGRRSFEGRICACPGRDRKADEDHYREQQALNESSAKNGAASKRAFKQSPPAVPALGAGVKKRRHGDEDTYYLQVRGRENFEILMKLKESLELMELVPQPLVDSYRQQQQLLQRPSHLQPPSYGPVLSPMNKVHGGMNKLPSVNQLVGQPPPHSSAATPNLGPVGPGMLNNHGHAVPANGEMSSSHSAQSMVSGSHCTPPPPYHADPSLVSFLTGLGCPNCIEYFTSQGLQSIYHLQNLTIEDLGALKIPEQYRMTIWRGLQDLKQGHDYSTAQQLLRSSNAATISIGGSGELQRQRVMEAVHFRVRHTITIPNRGGPGGGPDEWADFGFDLPDCKARKQPIKEEFTEAEIH
Atome Classification :
(21 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MAQSTATSPDGG
T
T
F
E
H
L
W
S
SLEPDS
T
Y
FDLPQSSRGNNEVVGGTDSS
M
D
V
F
H
LEGM
T
T
S
V
M
A
Q
F
N
L
L
S
S
T
M
D
Q
M
S
S
RAASASPYTPEHAASVPTHSPYAQPSSTFDTMSPAPVIPSNTDYPGP
H
H
F
E
V
T
F
QQSSTAKSATW
T
Y
S
P
L
L
K
K
L
Y
C
Q
I
AKTC
P
I
Q
I
K
VSTPPPPGT
A
I
R
AMP
V
Y
K
K
A
E
H
V
T
D
V
V
K
RCPN
H
E
LGRDFNEGQSAPA
S
H
L
I
R
V
EGN
N
L
S
Q
Y
VDDPVTGR
Q
S
V
V
V
PYEPPQVG
T
E
F
T
T
I
L
Y
N
FMCNSSCVGGMNRR
P
I
L
I
I
I
T
L
EMRDG
Q
V
L
GRRSFEG
R
I
C
ACPGRDRKA
D
E
D
H
Y
R
E
Q
Q
ALNESSAKNGAASKRAFKQSPPAVPAL
G
A
G
V
K
KRRHGDED
T
Y
Y
L
Q
V
RGRE
N
F
E
I
L
M
K
L
K
E
S
L
E
L
M
E
LVP
Q
P
L
V
D
S
Y
R
Q
Q
Q
Q
L
L
QRPSHLQPPSYGPVL
S
P
M
N
K
V
H
G
G
M
NKLP
S
V
N
Q
L
VGQPPPHSSAATPNLGPVGPGMLNNHGHAVPANGEMSSSH
S
A
Q
S
MVSGSHCTPPPPYHA
D
P
S
L
V
S
F
L
T
GLGC
P
N
C
I
E
Y
F
T
S
Q
G
L
Q
S
I
Y
H
L
QNL
T
I
E
DLGALKI
P
E
Q
Y
R
M
T
I
W
R
G
L
Q
D
L
K
QGH
D
Y
S
T
A
Q
Q
L
L
RSSN
A
A
T
I
S
IGGS
G
E
L
Q
R
Q
R
V
M
E
A
V
H
F
R
V
R
H
T
I
T
IPNRGGPGG
G
P
D
E
W
A
DFGFDLPD
C
K
A
RKQ
P
I
K
E
E
F
TEAEIH
2
PsiBlast_PDB
81.11
98%
-94
- C3 -
-
4A63
-
P73_HUMAN
A:
[4-205]
-----------------------------------------------------------------------------------------------------------------
V
I
P
S
N
T
D
Y
P
G
P
H
H
F
E
V
T
F
Q
Q
S
S
T
A
K
S
A
T
W
T
Y
S
P
L
L
K
K
L
Y
C
Q
I
A
K
T
C
P
I
Q
I
K
V
S
T
P
P
P
P
G
T
A
I
R
A
M
P
V
Y
K
K
A
E
H
V
T
D
V
V
K
R
C
P
N
H
E
L
G
R
D
F
N
E
G
Q
S
A
P
A
S
H
L
I
R
V
E
G
N
N
L
S
Q
Y
V
D
D
P
V
T
G
R
Q
S
V
V
V
P
Y
E
P
P
Q
V
G
T
E
F
T
T
I
L
Y
N
F
M
C
N
S
S
C
V
G
G
M
N
R
R
P
I
L
I
I
I
T
L
E
M
R
D
G
Q
V
L
G
R
R
S
F
E
G
R
I
C
A
C
P
G
R
D
R
K
A
D
E
D
H
Y
R
E
A
E
N
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
80.42
99%
-89
- C3 -
-
4A63
-
P73_HUMAN
C:
[4-203]
-----------------------------------------------------------------------------------------------------------------
V
I
P
S
N
T
D
Y
P
G
P
H
H
F
E
V
T
F
Q
Q
S
S
T
A
K
S
A
T
W
T
Y
S
P
L
L
K
K
L
Y
C
Q
I
A
K
T
C
P
I
Q
I
K
V
S
T
P
P
P
P
G
T
A
I
R
A
M
P
V
Y
K
K
A
E
H
V
T
D
V
V
K
R
C
P
N
H
E
L
G
R
D
F
N
E
G
Q
S
A
P
A
S
H
L
I
R
V
E
G
N
N
L
S
Q
Y
V
D
D
P
V
T
G
R
Q
S
V
V
V
P
Y
E
P
P
Q
V
G
T
E
F
T
T
I
L
Y
N
F
M
C
N
S
S
C
V
G
G
M
N
R
R
P
I
L
I
I
I
T
L
E
M
R
D
G
Q
V
L
G
R
R
S
F
E
G
R
I
C
A
C
P
G
R
D
R
K
A
D
E
D
H
Y
R
E
A
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
79.16
100%
-86
- C3 -
-
4GUO
-
P73_HUMAN
A:
[13-210]
------------------------------------------------------------------------------------------------------------------
I
P
S
N
T
D
Y
P
G
P
H
H
F
E
V
T
F
Q
Q
S
S
T
A
K
S
A
T
W
T
Y
S
P
L
L
K
K
L
Y
C
Q
I
A
K
T
C
P
I
Q
I
K
V
S
T
P
P
P
P
G
T
A
I
R
A
M
P
V
Y
K
K
A
E
H
V
T
D
V
V
K
R
C
P
N
H
E
L
G
R
D
F
N
E
G
Q
S
A
P
A
S
H
L
I
R
V
E
G
N
N
L
S
Q
Y
V
D
D
P
V
T
G
R
Q
S
V
V
V
P
Y
E
P
P
Q
V
G
T
E
F
T
T
I
L
Y
N
F
M
C
N
S
S
C
V
G
G
M
N
R
R
P
I
L
I
I
I
T
L
E
M
R
D
G
Q
V
L
G
R
R
S
F
E
G
R
I
C
A
C
P
G
R
D
R
K
A
D
E
D
H
Y
R
E
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
78.93
100%
-89
- C3 -
-
3VD1
-
P73_HUMAN
A:
[13-210]
------------------------------------------------------------------------------------------------------------------
I
P
S
N
T
D
Y
P
G
P
H
H
F
E
V
T
F
Q
Q
S
S
T
A
K
S
A
T
W
T
Y
S
P
L
L
K
K
L
Y
C
Q
I
A
K
T
C
P
I
Q
I
K
V
S
T
P
P
P
P
G
T
A
I
R
A
M
P
V
Y
K
K
A
E
H
V
T
D
V
V
K
R
C
P
N
H
E
L
G
R
D
F
N
E
G
Q
S
A
P
A
S
H
L
I
R
V
E
G
N
N
L
S
Q
Y
V
D
D
P
V
T
G
R
Q
S
V
V
V
P
Y
E
P
P
Q
V
G
T
E
F
T
T
I
L
Y
N
F
M
C
N
S
S
C
V
G
G
M
N
R
R
P
I
L
I
I
I
T
L
E
M
R
D
G
Q
V
L
G
R
R
S
F
E
G
R
I
C
A
C
P
G
R
D
R
K
A
D
E
D
H
Y
R
E
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
78.57
98%
-75
- C3 -
-
2XWC
2
P73_HUMAN
A:
[2-205]
---------------------------------------------------------------------------------------------------------------
A
P
V
I
P
S
N
T
D
Y
P
G
P
H
H
F
E
V
T
F
Q
Q
S
S
T
A
K
S
A
T
W
T
Y
S
P
L
L
K
K
L
Y
C
Q
I
A
K
T
C
P
I
Q
I
K
V
S
T
P
P
P
P
G
T
A
I
R
A
M
P
V
Y
K
K
A
E
H
V
T
D
V
V
K
R
C
P
N
H
E
L
G
R
D
F
N
E
G
Q
S
A
P
A
S
H
L
I
R
V
E
G
N
N
L
S
Q
Y
V
D
D
P
V
T
G
R
Q
S
V
V
V
P
Y
E
P
P
Q
V
G
T
E
F
T
T
I
L
Y
N
F
M
C
N
S
S
C
V
G
---
R
R
P
I
L
I
I
I
T
L
E
M
R
D
G
Q
V
L
G
R
R
S
F
E
G
R
I
C
A
C
P
G
R
D
R
K
A
D
E
D
H
Y
R
E
A
E
N
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
78.02
99%
-85
- C3 -
-
4GUQ
-
P73_HUMAN
A:
[13-210]
------------------------------------------------------------------------------------------------------------------
I
P
S
N
T
D
Y
P
G
P
H
H
F
E
V
T
F
Q
Q
S
S
T
A
K
F
A
T
W
T
Y
S
P
L
L
K
K
L
Y
C
Q
I
A
K
T
C
P
I
Q
I
K
V
S
T
P
P
P
P
G
T
A
I
R
A
M
P
V
Y
K
K
A
E
H
V
T
D
V
V
K
R
C
P
N
H
E
L
G
R
D
F
N
E
G
Q
S
A
P
A
S
H
L
I
R
V
E
G
N
N
L
S
Q
Y
V
D
D
P
V
T
G
R
Q
S
V
V
V
P
Y
E
P
P
Q
V
G
T
E
F
T
T
I
L
Y
N
F
M
C
N
S
S
C
V
G
G
M
N
R
R
P
I
L
I
I
I
T
L
E
M
R
D
G
Q
V
L
G
R
R
S
F
E
G
R
I
C
A
C
P
G
R
D
R
K
A
D
E
D
H
Y
R
E
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
78.01
100%
-91
- C3 -
-
4G83
-
P73_HUMAN
A:
[13-208]
------------------------------------------------------------------------------------------------------------------
I
P
S
N
T
D
Y
P
G
P
H
H
F
E
V
T
F
Q
Q
S
S
T
A
K
S
A
T
W
T
Y
S
P
L
L
K
K
L
Y
C
Q
I
A
K
T
C
P
I
Q
I
K
V
S
T
P
P
P
P
G
T
A
I
R
A
M
P
V
Y
K
K
A
E
H
V
T
D
V
V
K
R
C
P
N
H
E
L
G
R
D
F
N
E
G
Q
S
A
P
A
S
H
L
I
R
V
E
G
N
N
L
S
Q
Y
V
D
D
P
V
T
G
R
Q
S
V
V
V
P
Y
E
P
P
Q
V
G
T
E
F
T
T
I
L
Y
N
F
M
C
N
S
S
C
V
G
G
M
N
R
R
P
I
L
I
I
I
T
L
E
M
R
D
G
Q
V
L
G
R
R
S
F
E
G
R
I
C
A
C
P
G
R
D
R
K
A
D
E
D
H
Y
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
77.37
81%
-98
- C3 -
-
2RMN
-
P63_HUMAN
A:
[2-225]
------------------------------------------------------------------------------------------------------
S
S
T
F
D
A
L
S
P
S
P
A
I
P
S
N
T
D
Y
P
G
P
H
S
F
D
V
S
F
Q
Q
S
S
T
A
K
S
A
T
W
T
Y
S
T
E
L
K
K
L
Y
C
Q
I
A
K
T
C
P
I
Q
I
K
V
M
T
P
P
P
Q
G
A
V
I
R
A
M
P
V
Y
K
K
A
E
H
V
T
E
V
V
K
R
C
P
N
H
E
L
S
R
E
F
N
E
G
Q
I
A
P
P
S
H
L
I
R
V
E
G
N
S
H
A
Q
Y
V
E
D
P
I
T
G
R
Q
S
V
L
V
P
Y
E
P
P
Q
V
G
T
E
F
T
T
V
L
Y
N
F
M
C
N
S
S
C
V
G
G
M
N
R
R
P
I
L
I
I
V
T
L
E
T
R
D
G
Q
V
L
G
R
R
C
F
E
A
R
I
C
A
C
P
G
R
D
R
K
A
D
E
D
S
I
R
K
Q
Q
V
S
D
--
S
T
K
N
G
D
A
F
R
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
77.22
100%
-81
- C3 -
-
4G82
-
P73_HUMAN
A:
[13-210]
------------------------------------------------------------------------------------------------------------------
I
P
S
N
T
D
Y
P
G
P
H
H
F
E
V
T
F
Q
Q
S
S
T
A
K
S
A
T
W
T
Y
S
P
L
L
K
K
L
Y
C
Q
I
A
K
T
C
P
I
Q
I
K
V
S
T
P
P
P
P
G
T
A
I
R
A
M
P
V
Y
K
K
A
E
H
V
T
D
V
V
K
R
C
P
N
H
E
L
G
R
D
F
N
E
G
Q
S
A
P
A
S
H
L
I
R
V
E
G
N
N
L
S
Q
Y
V
D
D
P
V
T
G
R
Q
S
V
V
V
P
Y
E
P
P
Q
V
G
T
E
F
T
T
I
L
Y
N
F
M
C
N
S
S
C
V
G
G
M
N
R
R
P
I
L
I
I
I
T
L
E
M
R
D
G
Q
V
L
G
R
R
S
F
E
G
R
I
C
A
C
P
G
R
D
R
K
A
D
E
D
H
Y
R
E
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
77.14
83%
-98
- C3 -
-
2RMN
-
P63_HUMAN
A:
[2-221]
------------------------------------------------------------------------------------------------------
S
S
T
F
D
A
L
S
P
S
P
A
I
P
S
N
T
D
Y
P
G
P
H
S
F
D
V
S
F
Q
Q
S
S
T
A
K
S
A
T
W
T
Y
S
T
E
L
K
K
L
Y
C
Q
I
A
K
T
C
P
I
Q
I
K
V
M
T
P
P
P
Q
G
A
V
I
R
A
M
P
V
Y
K
K
A
E
H
V
T
E
V
V
K
R
C
P
N
H
E
L
S
R
E
F
N
E
G
Q
I
A
P
P
S
H
L
I
R
V
E
G
N
S
H
A
Q
Y
V
E
D
P
I
T
G
R
Q
S
V
L
V
P
Y
E
P
P
Q
V
G
T
E
F
T
T
V
L
Y
N
F
M
C
N
S
S
C
V
G
G
M
N
R
R
P
I
L
I
I
V
T
L
E
T
R
D
G
Q
V
L
G
R
R
C
F
E
A
R
I
C
A
C
P
G
R
D
R
K
A
D
E
D
S
I
R
K
Q
Q
V
S
--
D
S
T
K
N
G
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
76.93
100%
-71
- C3 -
-
3VD2
-
P73_HUMAN
A:
[13-210]
------------------------------------------------------------------------------------------------------------------
I
P
S
N
T
D
Y
P
G
P
H
H
F
E
V
T
F
Q
Q
S
S
T
A
K
S
A
T
W
T
Y
S
P
L
L
K
K
L
Y
C
Q
I
A
K
T
C
P
I
Q
I
K
V
S
T
P
P
P
P
G
T
A
I
R
A
M
P
V
Y
K
K
A
E
H
V
T
D
V
V
K
R
C
P
N
H
E
L
G
R
D
F
N
E
G
Q
S
A
P
A
S
H
L
I
R
V
E
G
N
N
L
S
Q
Y
V
D
D
P
V
T
G
R
Q
S
V
V
V
P
Y
E
P
P
Q
V
G
T
E
F
T
T
I
L
Y
N
F
M
C
N
S
S
C
V
G
G
M
N
R
R
P
I
L
I
I
I
T
L
E
M
R
D
G
Q
V
L
G
R
R
S
F
E
G
R
I
C
A
C
P
G
R
D
R
K
A
D
E
D
H
Y
R
E
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
76.17
100%
-78
- C3 -
-
5KBD
-
P73_HUMAN
A:
[10-207]
------------------------------------------------------------------------------------------------------------------
I
P
S
N
T
D
Y
P
G
P
H
H
F
E
V
T
F
Q
Q
S
S
T
A
K
S
A
T
W
T
Y
S
P
L
L
K
K
L
Y
C
Q
I
A
K
T
C
P
I
Q
I
K
V
S
T
P
P
P
P
G
T
A
I
R
A
M
P
V
Y
K
K
A
E
H
V
T
D
V
V
K
R
C
P
N
H
E
L
G
R
D
F
N
E
G
Q
S
A
P
A
S
H
L
I
R
V
E
G
N
N
L
S
Q
Y
V
D
D
P
V
T
G
R
Q
S
V
V
V
P
Y
E
P
P
Q
V
G
T
E
F
T
T
I
L
Y
N
F
M
C
N
S
S
C
V
G
G
M
N
R
R
P
I
L
I
I
I
T
L
E
M
R
D
G
Q
V
L
G
R
R
S
F
E
G
R
I
C
A
C
P
G
R
D
R
K
A
D
E
D
H
Y
R
E
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
76.06
100%
-81
- C3 -
-
3VD0
-
P73_HUMAN
A:
[13-210]
------------------------------------------------------------------------------------------------------------------
I
P
S
N
T
D
Y
P
G
P
H
H
F
E
V
T
F
Q
Q
S
S
T
A
K
S
A
T
W
T
Y
S
P
L
L
K
K
L
Y
C
Q
I
A
K
T
C
P
I
Q
I
K
V
S
T
P
P
P
P
G
T
A
I
R
A
M
P
V
Y
K
K
A
E
H
V
T
D
V
V
K
R
C
P
N
H
E
L
G
R
D
F
N
E
G
Q
S
A
P
A
S
H
L
I
R
V
E
G
N
N
L
S
Q
Y
V
D
D
P
V
T
G
R
Q
S
V
V
V
P
Y
E
P
P
Q
V
G
T
E
F
T
T
I
L
Y
N
F
M
C
N
S
S
C
V
G
G
M
N
R
R
P
I
L
I
I
I
T
L
E
M
R
D
G
Q
V
L
G
R
R
S
F
E
G
R
I
C
A
C
P
G
R
D
R
K
A
D
E
D
H
Y
R
E
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
71.93
85%
-92
- C3 -
-
3QYN
-
P63_HUMAN
A:
[7-200]
-------------------------------------------------------------------------------------------------------------------
P
S
N
T
D
Y
P
G
P
H
S
F
D
V
S
F
Q
Q
S
S
T
A
K
S
A
T
W
T
Y
S
T
E
L
K
K
L
Y
C
Q
I
A
K
T
C
P
I
Q
I
K
V
M
T
P
P
P
Q
G
A
V
I
R
A
M
P
V
Y
K
K
A
E
H
V
T
E
V
V
K
R
C
P
N
H
E
L
S
R
E
F
N
E
G
Q
I
A
P
P
S
H
L
I
R
V
E
G
N
S
H
A
Q
Y
V
E
D
P
I
T
G
R
Q
S
V
L
V
P
Y
E
P
P
Q
V
G
T
E
F
T
T
V
L
Y
N
F
M
C
N
S
S
C
V
G
G
M
N
R
R
P
I
L
I
I
V
T
L
E
T
R
D
G
Q
V
L
G
R
R
C
F
E
A
R
I
C
A
C
P
G
R
D
R
K
A
D
E
D
S
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
71.64
85%
-90
- C3 -
-
3US0
-
P63_HUMAN
A:
[7-200]
-------------------------------------------------------------------------------------------------------------------
P
S
N
T
D
Y
P
G
P
H
S
F
D
V
S
F
Q
Q
S
S
T
A
K
S
A
T
W
T
Y
S
T
E
L
K
K
L
Y
C
Q
I
A
K
T
C
P
I
Q
I
K
V
M
T
P
P
P
Q
G
A
V
I
R
A
M
P
V
Y
K
K
A
E
H
V
T
E
V
V
K
R
C
P
N
H
E
L
S
R
E
F
N
E
G
Q
I
A
P
P
S
H
L
I
R
V
E
G
N
S
H
A
Q
Y
V
E
D
P
I
T
G
R
Q
S
V
L
V
P
Y
E
P
P
Q
V
G
T
E
F
T
T
V
L
Y
N
F
M
C
N
S
S
C
V
G
G
M
N
R
R
P
I
L
I
I
V
T
L
E
T
R
D
G
Q
V
L
G
R
R
C
F
E
A
R
I
C
A
C
P
G
R
D
R
K
A
D
E
D
S
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
71.46
85%
-88
- C3 -
-
3US2
-
P63_HUMAN
A:
[7-199]
-------------------------------------------------------------------------------------------------------------------
P
S
N
T
D
Y
P
G
P
H
S
F
D
V
S
F
Q
Q
S
S
T
-
K
S
A
T
W
T
Y
S
T
E
L
K
K
L
Y
C
Q
I
A
K
T
C
P
I
Q
I
K
V
M
T
P
P
P
Q
G
A
V
I
R
A
M
P
V
Y
K
K
A
E
H
V
T
E
V
V
K
R
C
P
N
H
E
L
S
R
E
F
N
E
G
Q
I
A
P
P
S
H
L
I
R
V
E
G
N
S
H
A
Q
Y
V
E
D
P
I
T
G
R
Q
S
V
L
V
P
Y
E
P
P
Q
V
G
T
E
F
T
T
V
L
Y
N
F
M
C
N
S
S
C
V
G
G
M
N
R
R
P
I
L
I
I
V
T
L
E
T
R
D
G
Q
V
L
G
R
R
C
F
E
A
R
I
C
A
C
P
G
R
D
R
K
A
D
E
D
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
70.75
85%
-89
- C3 -
-
3US1
-
P63_HUMAN
A:
[7-199]
-------------------------------------------------------------------------------------------------------------------
P
S
N
T
D
Y
P
G
P
H
S
F
D
V
S
F
Q
Q
S
S
T
-
K
S
A
T
W
T
Y
S
T
E
L
K
K
L
Y
C
Q
I
A
K
T
C
P
I
Q
I
K
V
M
T
P
P
P
Q
G
A
V
I
R
A
M
P
V
Y
K
K
A
E
H
V
T
E
V
V
K
R
C
P
N
H
E
L
S
R
E
F
N
E
G
Q
I
A
P
P
S
H
L
I
R
V
E
G
N
S
H
A
Q
Y
V
E
D
P
I
T
G
R
Q
S
V
L
V
P
Y
E
P
P
Q
V
G
T
E
F
T
T
V
L
Y
N
F
M
C
N
S
S
C
V
G
G
M
N
R
R
P
I
L
I
I
V
T
L
E
T
R
D
G
Q
V
L
G
R
R
C
F
E
A
R
I
C
A
C
P
G
R
D
R
K
A
D
E
D
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
70.74
85%
-95
- C3 -
-
3QYM
-
P63_HUMAN
A:
[7-200]
-------------------------------------------------------------------------------------------------------------------
P
S
N
T
D
Y
P
G
P
H
S
F
D
V
S
F
Q
---
T
A
K
S
A
T
W
T
Y
S
T
E
L
K
K
L
Y
C
Q
I
A
K
T
C
P
I
Q
I
K
V
M
T
P
P
P
Q
G
A
V
I
R
A
M
P
V
Y
K
K
A
E
H
V
T
E
V
V
K
R
C
P
N
H
E
L
S
R
E
F
N
E
G
Q
I
A
P
P
S
H
L
I
R
V
E
G
N
S
H
A
Q
Y
V
E
D
P
I
T
G
R
Q
S
V
L
V
P
Y
E
P
P
Q
V
G
T
E
F
T
T
V
L
Y
N
F
M
C
N
S
S
C
V
G
G
M
N
R
R
P
I
L
I
I
V
T
L
E
T
R
D
G
Q
V
L
G
R
R
C
F
E
A
R
I
C
A
C
P
G
R
D
R
K
A
D
E
D
S
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
69.94
48%
-87
- C3 -
-
3Q05
-
P53_HUMAN
A:
[4-230]
------------------------------------------------------------------------------------------------------------------
V
P
S
Q
K
T
Y
Q
G
S
Y
G
F
R
L
G
F
L
H
S
G
T
A
K
S
V
T
C
T
Y
S
P
A
L
N
K
M
F
V
Q
L
A
K
T
V
P
V
Q
L
Y
V
D
S
T
P
P
P
G
T
R
V
R
A
M
A
I
Y
K
Q
S
Q
H
M
T
E
V
V
R
R
C
P
H
H
E
R
S
S
D
-
S
D
G
L
-
A
P
P
Q
H
L
I
R
V
E
G
N
L
R
A
E
Y
L
D
D
P
N
T
F
R
H
S
V
V
V
P
Y
E
P
P
E
V
G
S
D
Y
T
T
I
Y
F
K
F
M
C
N
S
S
C
M
G
G
M
N
R
R
P
I
L
V
I
I
T
L
E
D
S
S
G
N
L
L
G
R
D
S
F
E
V
R
V
C
A
C
P
G
R
D
R
R
T
E
E
E
N
L
R
K
K
T
M
------------------------------------
D
G
E
Y
F
T
L
Q
I
R
G
R
E
R
F
E
Q
F
R
E
R
N
E
A
L
E
L
K
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
69.83
48%
-96
- C3 -
-
3Q01
-
P53_HUMAN
A:
[4-229]
------------------------------------------------------------------------------------------------------------------
V
P
S
Q
K
T
Y
Q
G
S
Y
G
F
R
L
G
F
L
H
S
G
T
A
K
S
V
T
C
T
Y
S
P
A
L
N
K
M
F
V
Q
L
A
K
T
V
P
V
Q
L
Y
V
D
S
T
P
P
P
G
T
R
V
R
A
M
A
I
Y
K
Q
S
Q
H
M
T
E
V
V
R
R
C
P
H
H
E
R
S
S
D
-
S
D
G
L
-
A
P
P
Q
H
L
I
R
V
E
G
N
L
R
A
E
Y
L
D
D
P
N
T
F
R
H
S
V
V
V
P
Y
E
P
P
E
V
G
S
D
Y
T
T
I
Y
F
K
F
M
C
N
S
S
C
M
G
G
M
N
R
R
P
I
L
V
I
I
T
L
E
D
S
S
G
N
L
L
G
R
D
S
F
E
V
R
V
C
A
C
P
G
R
D
R
R
T
E
E
E
N
L
R
K
T
M
-------------------------------------
D
G
E
Y
F
T
L
Q
I
R
G
R
E
R
F
E
Q
F
R
E
R
N
E
A
L
E
L
K
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
68.06
58%
-88
- C3 -
-
5AOK
3
P53_HUMAN
B:
[1-198]
---------------------------------------------------------------------------------------------------------------
S
S
S
V
P
S
Q
K
T
Y
Q
G
S
Y
G
F
R
L
G
F
L
H
S
G
T
A
K
S
V
T
C
T
Y
S
P
A
L
N
K
L
F
C
Q
L
A
K
T
C
P
V
Q
L
W
V
D
S
T
P
P
P
G
T
R
V
R
A
M
A
I
Y
K
Q
S
Q
H
M
T
E
V
V
R
R
C
P
H
H
E
R
C
S
D
S
D
-
G
-
L
A
P
P
Q
H
L
I
R
V
E
G
N
L
R
A
E
Y
L
D
D
R
N
T
F
R
H
S
V
V
V
P
C
E
P
P
E
V
G
S
D
C
T
T
I
H
Y
N
Y
M
C
Y
S
S
C
M
G
G
M
N
R
R
P
I
L
T
I
I
T
L
E
D
S
S
G
N
L
L
G
R
D
S
F
E
V
R
V
C
A
C
P
G
R
D
R
R
T
E
E
E
N
L
R
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------