@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : TBB2A_HUMAN: (2018-10-06 )
MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEAAGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETYSIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMMAACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATADEQGEFEEEEGEDEA
Atome Classification :
(23 SA)
.........10........20........30........40...---.....50........60........70........80........90..--......100.......110.......120.......130.......140.......150.......160.......170..-.....180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280........290.......300...-....310.......320.......330.......340.......350......-.360------.........370.......380.......390.......400.......410--........420.......430.......440...
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
R
E
I
V
H
I
QAGQCG
N
Q
I
G
A
K
F
W
E
V
I
SDEHGIDPTGSYHGDSD
L
Q
L
---
E
R
I
N
V
Y
Y
NEAAGNKYV
P
R
A
I
L
V
DLEPGT
M
D
S
VRSGPFGQIFRPD
N
F
V
FG--QSGAGNNWAKGHYT
E
G
A
E
L
V
D
S
V
L
D
V
V
R
KESESC
D
C
L
Q
G
F
Q
L
T
H
SLGGGTGS
G
M
G
T
L
L
I
S
K
I
R
E
EY
P
D
R
I
M
N
T
F
SVMPSPK-VSD
T
V
VEPYN
A
T
L
S
V
H
Q
L
V
ENTDETYSI
D
N
E
A
L
Y
D
I
C
F
R
T
L
KLTTPTYG
D
L
N
H
L
V
S
A
T
M
S
G
V
T
T
C
L
RFPGQL
N
A
D
L
R
K
L
A
V
NMVPFP
R
L
H
F
FMPGFAPLTSRGSQ
Q
-
Y
R
A
L
T
V
P
E
L
T
Q
Q
M
FDSKNM
M
A
ACDP-RHG
R
Y
L
T
V
A
A
I
F
RGRM
S
M
K
E
V
D
E
Q
M
L
N
VQNKNS
S
Y
F
V
E
WIPNNV
K
T
A
VCDIPP-RG--------
L
K
M
S
A
T
FIG
N
S
T
A
I
Q
E
L
F
K
R
I
S
E
Q
F
T
A
M
F
R
R
K
A
F
L
H
W
YTGEGMD
E
M
E
F
T
E
A
---ES
N
M
N
D
L
V
S
E
Y
Q
Q
Y
QDATADEQGEFEEEEGEDEA
2
PsiBlast_PDB
94.31
99%
-85
- C2 -
-
4HNA
2
?
B:
[1-431]
M
R
E
I
V
H
I
Q
A
G
Q
C
G
N
Q
I
G
A
K
F
W
E
V
I
S
D
E
H
G
I
D
P
T
G
S
Y
H
G
D
S
D
L
Q
L
---
E
R
I
N
V
Y
Y
N
E
A
T
G
N
K
Y
V
P
R
A
I
L
V
D
L
E
P
G
T
M
D
S
V
R
S
G
P
F
G
Q
I
F
R
P
D
N
F
V
F
G
--
Q
S
G
A
G
N
N
W
A
K
G
H
Y
T
E
G
A
E
L
V
D
S
V
L
D
V
V
R
K
E
S
E
S
C
D
C
L
Q
G
F
Q
L
T
H
S
L
G
G
G
T
G
S
G
M
G
T
L
L
I
S
K
I
R
E
E
Y
P
D
R
I
M
N
T
F
S
V
M
P
S
P
K
-
V
S
D
T
V
V
E
P
Y
N
A
T
L
S
V
H
Q
L
V
E
N
T
D
E
T
Y
S
I
D
N
E
A
L
Y
D
I
C
F
R
T
L
K
L
T
T
P
T
Y
G
D
L
N
H
L
V
S
A
T
M
S
G
V
T
T
C
L
R
F
P
G
Q
L
N
A
D
L
R
K
L
A
V
N
M
V
P
F
P
R
L
H
F
F
M
P
G
F
A
P
L
T
S
R
G
S
Q
Q
-
Y
R
A
L
T
V
P
E
L
T
Q
Q
M
F
D
S
K
N
M
M
A
A
C
D
P
-
R
H
G
R
Y
L
T
V
A
A
I
F
R
G
R
M
S
M
K
E
V
D
E
Q
M
L
N
V
Q
N
K
N
S
S
Y
F
V
E
W
I
P
N
N
V
K
T
A
V
C
D
I
P
P
-
R
G
--------
L
K
M
S
A
T
F
I
G
N
S
T
A
I
Q
E
L
F
K
R
I
S
E
Q
F
T
A
M
F
R
R
K
A
F
L
H
W
Y
T
G
E
G
M
D
E
M
E
F
T
E
A
---
E
S
N
M
N
D
L
V
S
E
Y
Q
Q
Y
Q
D
A
T
A
D
--------------
5
PsiBlast_PDB
93.36
99%
-84
- C2 -
-
5EIB
2
TBB2B_BOVIN
D:
[2-431]
-
R
E
I
V
H
I
Q
A
G
Q
C
G
N
Q
I
G
A
K
F
W
E
V
I
S
D
E
H
G
I
D
P
T
G
S
Y
H
G
D
S
D
L
Q
L
---
E
R
I
N
V
Y
Y
N
E
A
T
G
N
K
Y
V
P
R
A
I
L
V
D
L
E
P
G
T
M
D
S
V
R
S
G
P
F
G
Q
I
F
R
P
D
N
F
V
F
G
--
Q
S
G
A
G
N
N
W
A
K
G
H
Y
T
E
G
A
E
L
V
D
S
V
L
D
V
V
R
K
E
S
E
S
C
D
C
L
Q
G
F
Q
L
T
H
S
L
G
G
G
T
G
S
G
M
G
T
L
L
I
S
K
I
R
E
E
Y
P
D
R
I
M
N
T
F
S
V
M
P
S
P
K
-
V
S
D
T
V
V
E
P
Y
N
A
T
L
S
V
H
Q
L
V
E
N
T
D
E
T
Y
S
I
D
N
E
A
L
Y
D
I
C
F
R
T
L
K
L
T
T
P
T
Y
G
D
L
N
H
L
V
S
A
T
M
S
G
V
T
T
C
L
R
F
P
G
Q
L
N
A
D
L
R
K
L
A
V
N
M
V
P
F
P
R
L
H
F
F
M
P
G
F
A
P
L
T
S
R
G
S
Q
Q
-
Y
R
A
L
T
V
P
E
L
T
Q
Q
M
F
D
S
K
N
M
M
A
A
C
D
P
-
R
H
G
R
Y
L
T
V
A
A
I
F
R
G
R
M
S
M
K
E
V
D
E
Q
M
L
N
V
Q
N
K
N
S
S
Y
F
V
E
W
I
P
N
N
V
K
T
A
V
C
D
I
P
P
-
R
G
--------
L
K
M
S
A
T
F
I
G
N
S
T
A
I
Q
E
L
F
K
R
I
S
E
Q
F
T
A
M
F
R
R
K
A
F
L
H
W
Y
T
G
E
G
M
D
E
M
E
F
T
E
A
---
E
S
N
M
N
D
L
V
S
E
Y
Q
Q
Y
Q
D
A
T
A
D
--------------
1
PsiBlast_PDB
93.15
99%
-80
- C2 -
-
4F61
2
?
B:
[1-432]
M
R
E
I
V
H
I
Q
A
G
Q
C
G
N
Q
I
G
A
K
F
W
E
V
I
S
D
E
H
G
I
D
P
T
G
S
Y
H
G
D
S
D
L
Q
L
---
E
R
I
N
V
Y
Y
N
E
A
T
G
N
K
Y
V
P
R
A
I
L
V
D
L
E
P
G
T
M
D
S
V
R
S
G
P
F
G
Q
I
F
R
P
D
N
F
V
F
G
--
Q
S
G
A
G
N
N
W
A
K
G
H
Y
T
E
G
A
E
L
V
D
S
V
L
D
V
V
R
K
E
S
E
S
C
D
C
L
Q
G
F
Q
L
T
H
S
L
G
G
G
T
G
S
G
M
G
T
L
L
I
S
K
I
R
E
E
Y
P
D
R
I
M
N
T
F
S
V
M
P
S
P
K
-
V
S
D
T
V
V
E
P
Y
N
A
T
L
S
V
H
Q
L
V
E
N
T
D
E
T
Y
S
I
D
N
E
A
L
Y
D
I
C
F
R
T
L
K
L
T
T
P
T
Y
G
D
L
N
H
L
V
S
A
T
M
S
G
V
T
T
C
L
R
F
P
G
Q
L
N
A
D
L
R
K
L
A
V
N
M
V
P
F
P
R
L
H
F
F
M
P
G
F
A
P
L
T
S
R
G
S
Q
Q
-
Y
R
A
L
T
V
P
E
L
T
Q
Q
M
F
D
S
K
N
M
M
A
A
C
D
P
-
R
H
G
R
Y
L
T
V
A
A
I
F
R
G
R
M
S
M
K
E
V
D
E
Q
M
L
N
V
Q
N
K
N
S
S
Y
F
V
E
W
I
P
N
N
V
K
T
A
V
C
D
I
P
P
-
R
G
--------
L
K
M
S
A
T
F
I
G
N
S
T
A
I
Q
E
L
F
K
R
I
S
E
Q
F
T
A
M
F
R
R
K
A
F
L
H
W
Y
T
G
E
G
M
D
E
M
E
F
T
E
A
---
E
S
N
M
N
D
L
V
S
E
Y
Q
Q
Y
Q
D
A
T
A
D
E
-------------
18
PsiBlast_PDB
93.09
99%
-81
- C2 -
-
5KX5
3
?
B:
[1-430]
M
R
E
I
V
H
I
Q
A
G
Q
C
G
N
Q
I
G
A
K
F
W
E
V
I
S
D
E
H
G
I
D
P
T
G
S
Y
H
G
D
S
D
L
Q
L
---
E
R
I
N
V
Y
Y
N
E
A
T
G
N
K
Y
V
P
R
A
I
L
V
D
L
E
P
G
T
M
D
S
V
R
S
G
P
F
G
Q
I
F
R
P
D
N
F
V
F
G
--
Q
S
G
A
G
N
N
W
A
K
G
H
Y
T
E
G
A
E
L
V
D
S
V
L
D
V
V
R
K
E
S
E
S
C
D
C
L
Q
G
F
Q
L
T
H
S
L
G
G
G
T
G
S
G
M
G
T
L
L
I
S
K
I
R
E
E
Y
P
D
R
I
M
N
T
F
S
V
M
P
S
P
K
-
V
S
D
T
V
V
E
P
Y
N
A
T
L
S
V
H
Q
L
V
E
N
T
D
E
T
Y
S
I
D
N
E
A
L
Y
D
I
C
F
R
T
L
K
L
T
T
P
T
Y
G
D
L
N
H
L
V
S
A
T
M
S
G
V
T
T
C
L
R
F
P
G
Q
L
N
A
D
L
R
K
L
A
V
N
M
V
P
F
P
R
L
H
F
F
M
P
G
F
A
P
L
T
S
R
G
----
Y
R
A
L
T
V
P
E
L
T
Q
Q
M
F
D
S
K
N
M
M
A
A
C
D
P
-
R
H
G
R
Y
L
T
V
A
A
V
F
R
G
R
M
S
M
K
E
V
D
E
Q
M
L
N
V
Q
N
K
N
S
S
Y
F
V
E
W
I
P
N
N
V
K
T
A
V
C
D
I
P
P
-
R
G
--------
L
K
M
S
A
T
F
I
G
N
S
T
A
I
Q
E
L
F
K
R
I
S
E
Q
F
T
A
M
F
R
R
K
A
F
L
H
W
Y
T
G
E
G
M
D
E
M
E
F
T
E
A
---
E
S
N
M
N
D
L
V
S
E
Y
Q
Q
Y
Q
D
A
T
A
---------------
17
PsiBlast_PDB
92.89
99%
-89
- C2 -
-
4X20
4
?
B:
[3-430]
--
E
I
V
H
I
Q
A
G
Q
C
G
N
Q
I
G
A
K
F
W
E
V
I
S
D
E
H
G
I
D
P
T
G
S
Y
H
G
D
S
D
L
Q
L
---
E
R
I
N
V
Y
Y
N
E
A
T
G
N
K
Y
V
P
R
A
I
L
V
D
L
E
P
G
T
M
D
S
V
R
S
G
P
F
G
Q
I
F
R
P
D
N
F
V
F
G
--
Q
S
G
A
G
N
N
W
A
K
G
H
Y
T
E
G
A
E
L
V
D
S
V
L
D
V
V
R
K
E
S
E
S
C
D
C
L
Q
G
F
Q
L
T
H
S
L
G
G
G
T
G
S
G
M
G
T
L
L
I
S
K
I
R
E
E
Y
P
D
R
I
M
N
T
F
S
V
M
P
S
P
K
-
V
S
D
T
V
V
E
P
Y
N
A
T
L
S
V
H
Q
L
V
E
N
T
D
E
T
Y
S
I
D
N
E
A
L
Y
D
I
C
F
R
T
L
K
L
T
T
P
T
Y
G
D
L
N
H
L
V
S
A
T
M
S
G
V
T
T
C
L
R
F
P
G
Q
L
N
A
D
L
R
K
L
A
V
N
M
V
P
F
P
R
L
H
F
F
M
P
G
F
A
P
L
T
S
R
G
S
Q
Q
-
Y
R
A
L
T
V
P
E
L
T
Q
Q
M
F
D
S
K
N
M
M
A
A
C
D
P
-
R
H
G
R
Y
L
T
V
A
A
V
F
R
G
R
M
S
M
K
E
V
D
E
Q
M
L
N
V
Q
N
K
N
S
S
Y
F
V
E
W
I
P
N
N
V
K
T
A
V
C
D
I
P
P
-
R
G
--------
L
K
M
S
A
T
F
I
G
N
S
T
A
I
Q
E
L
F
K
R
I
S
E
Q
F
T
A
M
F
R
R
K
A
F
L
H
W
Y
T
G
E
G
M
D
E
M
E
F
T
E
A
---
E
S
N
M
N
D
L
V
S
E
Y
Q
Q
Y
Q
D
A
T
A
---------------
16
PsiBlast_PDB
92.89
99%
-87
- C2 -
-
4X1Y
4
?
B:
[3-430]
--
E
I
V
H
I
Q
A
G
Q
C
G
N
Q
I
G
A
K
F
W
E
V
I
S
D
E
H
G
I
D
P
T
G
S
Y
H
G
D
S
D
L
Q
L
---
E
R
I
N
V
Y
Y
N
E
A
T
G
N
K
Y
V
P
R
A
I
L
V
D
L
E
P
G
T
M
D
S
V
R
S
G
P
F
G
Q
I
F
R
P
D
N
F
V
F
G
--
Q
S
G
A
G
N
N
W
A
K
G
H
Y
T
E
G
A
E
L
V
D
S
V
L
D
V
V
R
K
E
S
E
S
C
D
C
L
Q
G
F
Q
L
T
H
S
L
G
G
G
T
G
S
G
M
G
T
L
L
I
S
K
I
R
E
E
Y
P
D
R
I
M
N
T
F
S
V
M
P
S
P
K
-
V
S
D
T
V
V
E
P
Y
N
A
T
L
S
V
H
Q
L
V
E
N
T
D
E
T
Y
S
I
D
N
E
A
L
Y
D
I
C
F
R
T
L
K
L
T
T
P
T
Y
G
D
L
N
H
L
V
S
A
T
M
S
G
V
T
T
C
L
R
F
P
G
Q
L
N
A
D
L
R
K
L
A
V
N
M
V
P
F
P
R
L
H
F
F
M
P
G
F
A
P
L
T
S
R
G
S
Q
Q
-
Y
R
A
L
T
V
P
E
L
T
Q
Q
M
F
D
S
K
N
M
M
A
A
C
D
P
-
R
H
G
R
Y
L
T
V
A
A
V
F
R
G
R
M
S
M
K
E
V
D
E
Q
M
L
N
V
Q
N
K
N
S
S
Y
F
V
E
W
I
P
N
N
V
K
T
A
V
C
D
I
P
P
-
R
G
--------
L
K
M
S
A
T
F
I
G
N
S
T
A
I
Q
E
L
F
K
R
I
S
E
Q
F
T
A
M
F
R
R
K
A
F
L
H
W
Y
T
G
E
G
M
D
E
M
E
F
T
E
A
---
E
S
N
M
N
D
L
V
S
E
Y
Q
Q
Y
Q
D
A
T
A
---------------
3
PsiBlast_PDB
92.82
99%
-83
- C2 -
-
3J8X
2
?
B:
[1-431]
M
R
E
I
V
H
I
Q
A
G
Q
C
G
N
Q
I
G
A
K
F
W
E
V
I
S
D
E
H
G
I
D
P
T
G
S
Y
H
G
D
S
D
L
Q
L
---
E
R
I
N
V
Y
Y
N
E
A
T
G
N
K
Y
V
P
R
A
I
L
V
D
L
E
P
G
T
M
D
S
V
R
S
G
P
F
G
Q
I
F
R
P
D
N
F
V
F
G
--
Q
S
G
A
G
N
N
W
A
K
G
H
Y
T
E
G
A
E
L
V
D
S
V
L
D
V
V
R
K
E
S
E
S
C
D
C
L
Q
G
F
Q
L
T
H
S
L
G
G
G
T
G
S
G
M
G
T
L
L
I
S
K
I
R
E
E
Y
P
D
R
I
M
N
T
F
S
V
M
P
S
P
K
-
V
S
D
T
V
V
E
P
Y
N
A
T
L
S
V
H
Q
L
V
E
N
T
D
E
T
Y
S
I
D
N
E
A
L
Y
D
I
C
F
R
T
L
K
L
T
T
P
T
Y
G
D
L
N
H
L
V
S
A
T
M
S
G
V
T
T
C
L
R
F
P
G
Q
L
N
A
D
L
R
K
L
A
V
N
M
V
P
F
P
R
L
H
F
F
M
P
G
F
A
P
L
T
S
R
G
S
Q
Q
-
Y
R
A
L
T
V
P
E
L
T
Q
Q
M
F
D
S
K
N
M
M
A
A
C
D
P
-
R
H
G
R
Y
L
T
V
A
A
I
F
R
G
R
M
S
M
K
E
V
D
E
Q
M
L
N
V
Q
N
K
N
S
S
Y
F
V
E
W
I
P
N
N
V
K
T
A
V
C
D
I
P
P
-
R
G
--------
L
K
M
S
A
T
F
I
G
N
S
T
A
I
Q
E
L
F
K
R
I
S
E
Q
F
T
A
M
F
R
R
K
A
F
L
H
W
Y
T
G
E
G
M
D
E
M
E
F
T
E
A
---
E
S
N
M
N
D
L
V
S
E
Y
Q
Q
Y
Q
D
A
T
A
D
--------------
20
PsiBlast_PDB
92.74
99%
-88
- C2 -
-
4I4T
7
TBB2B_BOVIN
B:
[1-428]
M
R
E
I
V
H
I
Q
A
G
Q
C
G
N
Q
I
G
A
K
F
W
E
V
I
S
D
E
H
G
I
D
P
T
G
S
Y
H
G
D
S
D
L
Q
L
---
E
R
I
N
V
Y
Y
N
E
A
T
G
N
K
Y
V
P
R
A
I
L
V
D
L
E
P
G
T
M
D
S
V
R
S
G
P
F
G
Q
I
F
R
P
D
N
F
V
F
G
--
Q
S
G
A
G
N
N
W
A
K
G
H
Y
T
E
G
A
E
L
V
D
S
V
L
D
V
V
R
K
E
S
E
S
C
D
C
L
Q
G
F
Q
L
T
H
S
L
G
G
G
T
G
S
G
M
G
T
L
L
I
S
K
I
R
E
E
Y
P
D
R
I
M
N
T
F
S
V
M
P
S
P
K
-
V
S
D
T
V
V
E
P
Y
N
A
T
L
S
V
H
Q
L
V
E
N
T
D
E
T
Y
C
I
D
N
E
A
L
Y
D
I
C
F
R
T
L
K
L
T
T
P
T
Y
G
D
L
N
H
L
V
S
A
T
M
S
G
V
T
T
C
L
R
F
P
G
Q
L
N
A
D
L
R
K
L
A
V
N
M
V
P
F
P
R
L
H
F
F
M
P
G
F
A
P
L
T
S
---------
L
T
V
P
E
L
T
Q
Q
M
F
D
S
K
N
M
M
A
A
C
D
P
-
R
H
G
R
Y
L
T
V
A
A
I
F
R
G
R
M
S
M
K
E
V
D
E
Q
M
L
N
V
Q
N
K
N
S
S
Y
F
V
E
W
I
P
N
N
V
K
T
A
V
C
D
I
P
P
-
R
G
--------
L
K
M
S
A
T
F
I
G
N
S
T
A
I
Q
E
L
F
K
R
I
S
E
Q
F
T
A
M
F
R
R
K
A
F
L
H
W
Y
T
G
E
G
M
D
E
M
E
F
T
E
A
---
E
S
N
M
N
D
L
V
S
E
Y
Q
Q
Y
Q
D
A
-----------------
38
HHSearch
92.70
100%
-84
- C2 -
-
5IYZ
3
TBB2B_BOVIN
D:
[1-431]
M
R
E
I
V
H
I
Q
A
G
Q
C
G
N
Q
I
G
A
K
F
W
E
V
I
S
D
E
H
G
I
D
P
T
G
S
Y
H
G
D
S
D
L
Q
L
---
E
R
I
N
V
Y
Y
N
E
A
T
G
N
K
Y
V
P
R
A
I
L
V
D
L
E
P
G
T
M
D
S
V
R
S
G
P
F
G
Q
I
F
R
P
D
N
F
V
F
G
--
Q
S
G
A
G
N
N
W
A
K
G
H
Y
T
E
G
A
E
L
V
D
S
V
L
D
V
V
R
K
E
S
E
S
C
D
C
L
Q
G
F
Q
L
T
H
S
L
G
G
G
T
G
S
G
M
G
T
L
L
I
S
K
I
R
E
E
Y
P
D
R
I
M
N
T
F
S
V
M
P
S
P
K
-
V
S
D
T
V
V
E
P
Y
N
A
T
L
S
V
H
Q
L
V
E
N
T
D
E
T
Y
C
I
D
N
E
A
L
Y
D
I
C
F
R
T
L
K
L
T
T
P
T
Y
G
D
L
N
H
L
V
S
A
T
M
S
G
V
T
T
C
L
R
F
P
G
Q
L
N
A
D
L
R
K
L
A
V
N
M
V
P
F
P
R
L
H
F
F
M
P
G
F
A
P
L
T
S
R
--------
L
T
V
P
E
L
T
Q
Q
M
F
D
S
K
N
M
M
A
A
C
D
P
-
R
H
G
R
Y
L
T
V
A
A
I
F
R
G
R
M
S
M
K
E
V
D
E
Q
M
L
N
V
Q
N
K
N
S
S
Y
F
V
E
W
I
P
N
N
V
K
T
A
V
C
D
I
P
P
-
R
G
--------
L
K
M
S
A
T
F
I
G
N
S
T
A
I
Q
E
L
F
K
R
I
S
E
Q
F
T
A
M
F
R
R
K
A
F
L
H
W
Y
T
G
E
G
M
D
E
M
E
F
T
E
A
---
E
S
N
M
N
D
L
V
S
E
Y
Q
Q
Y
Q
D
A
T
A
D
--------------
14
PsiBlast_PDB
92.69
99%
-90
- C2 -
-
4X1I
4
?
B:
[3-430]
--
E
I
V
H
I
Q
A
G
Q
C
G
N
Q
I
G
A
K
F
W
E
V
I
S
D
E
H
G
I
D
P
T
G
S
Y
H
G
D
S
D
L
Q
L
---
E
R
I
N
V
Y
Y
N
E
A
T
G
N
K
Y
V
P
R
A
I
L
V
D
L
E
P
G
T
M
D
S
V
R
S
G
P
F
G
Q
I
F
R
P
D
N
F
V
F
G
--
Q
S
G
A
G
N
N
W
A
K
G
H
Y
T
E
G
A
E
L
V
D
S
V
L
D
V
V
R
K
E
S
E
S
C
D
C
L
Q
G
F
Q
L
T
H
S
L
G
G
G
T
G
S
G
M
G
T
L
L
I
S
K
I
R
E
E
Y
P
D
R
I
M
N
T
F
S
V
M
P
S
P
K
-
V
S
D
T
V
V
E
P
Y
N
A
T
L
S
V
H
Q
L
V
E
N
T
D
E
T
Y
S
I
D
N
E
A
L
Y
D
I
C
F
R
T
L
K
L
T
T
P
T
Y
G
D
L
N
H
L
V
S
A
T
M
S
G
V
T
T
C
L
R
F
P
G
Q
L
N
A
D
L
R
K
L
A
V
N
M
V
P
F
P
R
L
H
F
F
M
P
G
F
A
P
L
T
S
R
G
S
Q
Q
-
Y
R
A
L
T
V
P
E
L
T
Q
Q
M
F
D
S
K
N
M
M
A
A
C
D
P
-
R
H
G
R
Y
L
T
V
A
A
V
F
R
G
R
M
S
M
K
E
V
D
E
Q
M
L
N
V
Q
N
K
N
S
S
Y
F
V
E
W
I
P
N
N
V
K
T
A
V
C
D
I
P
P
-
R
G
--------
L
K
M
S
A
T
F
I
G
N
S
T
A
I
Q
E
L
F
K
R
I
S
E
Q
F
T
A
M
F
R
R
K
A
F
L
H
W
Y
T
G
E
G
M
D
E
M
E
F
T
E
A
---
E
S
N
M
N
D
L
V
S
E
Y
Q
Q
Y
Q
D
A
T
A
---------------
15
PsiBlast_PDB
92.24
99%
-91
- C2 -
-
4X1K
4
?
B:
[3-430]
--
E
I
V
H
I
Q
A
G
Q
C
G
N
Q
I
G
A
K
F
W
E
V
I
S
D
E
H
G
I
D
P
T
G
S
Y
H
G
D
S
D
L
Q
L
---
E
R
I
N
V
Y
Y
N
E
A
T
G
N
K
Y
V
P
R
A
I
L
V
D
L
E
P
G
T
M
D
S
V
R
S
G
P
F
G
Q
I
F
R
P
D
N
F
V
F
G
--
Q
S
G
A
G
N
N
W
A
K
G
H
Y
T
E
G
A
E
L
V
D
S
V
L
D
V
V
R
K
E
S
E
S
C
D
C
L
Q
G
F
Q
L
T
H
S
L
G
G
G
T
G
S
G
M
G
T
L
L
I
S
K
I
R
E
E
Y
P
D
R
I
M
N
T
F
S
V
M
P
S
P
K
-
V
S
D
T
V
V
E
P
Y
N
A
T
L
S
V
H
Q
L
V
E
N
T
D
E
T
Y
S
I
D
N
E
A
L
Y
D
I
C
F
R
T
L
K
L
T
T
P
T
Y
G
D
L
N
H
L
V
S
A
T
M
S
G
V
T
T
C
L
R
F
P
G
Q
L
N
A
D
L
R
K
L
A
V
N
M
V
P
F
P
R
L
H
F
F
M
P
G
F
A
P
L
T
S
R
G
S
Q
Q
-
Y
R
A
L
T
V
P
E
L
T
Q
Q
M
F
D
S
K
N
M
M
A
A
C
D
P
-
R
H
G
R
Y
L
T
V
A
A
V
F
R
G
R
M
S
M
K
E
V
D
E
Q
M
L
N
V
Q
N
K
N
S
S
Y
F
V
E
W
I
P
N
N
V
K
T
A
V
C
D
I
P
P
-
R
G
--------
L
K
M
S
A
T
F
I
G
N
S
T
A
I
Q
E
L
F
K
R
I
S
E
Q
F
T
A
M
F
R
R
K
A
F
L
H
W
Y
T
G
E
G
M
D
E
M
E
F
T
E
A
---
E
S
N
M
N
D
L
V
S
E
Y
Q
Q
Y
Q
D
A
T
A
---------------
4
PsiBlast_PDB
91.95
99%
-77
- C2 -
-
3J8Y
2
?
B:
[1-431]
M
R
E
I
V
H
I
Q
A
G
Q
C
G
N
Q
I
G
A
K
F
W
E
V
I
S
D
E
H
G
I
D
P
T
G
S
Y
H
G
D
S
D
L
Q
L
---
E
R
I
N
V
Y
Y
N
E
A
T
G
N
K
Y
V
P
R
A
I
L
V
D
L
E
P
G
T
M
D
S
V
R
S
G
P
F
G
Q
I
F
R
P
D
N
F
V
F
G
--
Q
S
G
A
G
N
N
W
A
K
G
H
Y
T
E
G
A
E
L
V
D
S
V
L
D
V
V
R
K
E
S
E
S
C
D
C
L
Q
G
F
Q
L
T
H
S
L
G
G
G
T
G
S
G
M
G
T
L
L
I
S
K
I
R
E
E
Y
P
D
R
I
M
N
T
F
S
V
M
P
S
P
K
-
V
S
D
T
V
V
E
P
Y
N
A
T
L
S
V
H
Q
L
V
E
N
T
D
E
T
Y
S
I
D
N
E
A
L
Y
D
I
C
F
R
T
L
K
L
T
T
P
T
Y
G
D
L
N
H
L
V
S
A
T
M
S
G
V
T
T
C
L
R
F
P
G
Q
L
N
A
D
L
R
K
L
A
V
N
M
V
P
F
P
R
L
H
F
F
M
P
G
F
A
P
L
T
S
R
G
S
Q
Q
-
Y
R
A
L
T
V
P
E
L
T
Q
Q
M
F
D
S
K
N
M
M
A
A
C
D
P
-
R
H
G
R
Y
L
T
V
A
A
I
F
R
G
R
M
S
M
K
E
V
D
E
Q
M
L
N
V
Q
N
K
N
S
S
Y
F
V
E
W
I
P
N
N
V
K
T
A
V
C
D
I
P
P
-
R
G
--------
L
K
M
S
A
T
F
I
G
N
S
T
A
I
Q
E
L
F
K
R
I
S
E
Q
F
T
A
M
F
R
R
K
A
F
L
H
W
Y
T
G
E
G
M
D
E
M
E
F
T
E
A
---
E
S
N
M
N
D
L
V
S
E
Y
Q
Q
Y
Q
D
A
T
A
D
--------------
13
PsiBlast_PDB
89.98
99%
-83
- C2 -
-
3N2K
3
?
B:
[2-429]
-
R
E
I
V
H
I
Q
A
G
Q
C
G
N
Q
I
G
A
K
F
W
E
V
I
S
D
E
H
G
I
D
P
T
G
S
Y
H
G
D
S
D
L
Q
L
---
E
R
I
N
V
Y
Y
N
E
A
T
G
N
K
Y
V
P
R
A
I
L
V
D
L
E
P
G
T
M
D
S
V
R
S
G
P
F
G
Q
I
F
R
P
D
N
F
V
F
G
--
Q
S
G
A
G
N
N
W
A
K
G
H
Y
T
E
G
A
E
L
V
D
S
V
L
D
V
V
R
K
E
S
E
S
C
D
C
L
Q
G
F
Q
L
T
H
S
L
G
G
G
T
G
S
G
M
G
T
L
L
I
S
K
I
R
E
E
Y
P
D
R
I
M
N
T
F
S
V
M
P
S
P
K
-
V
S
D
T
V
V
E
P
Y
N
A
T
L
S
V
H
Q
L
V
E
N
T
D
E
T
Y
S
I
D
N
E
A
L
Y
D
I
C
F
R
T
L
K
L
T
T
P
T
Y
G
D
L
N
H
L
V
S
A
T
M
S
G
V
T
T
C
L
R
F
P
G
Q
L
N
A
D
L
R
K
L
A
V
N
M
V
P
F
P
R
L
H
F
F
M
P
G
F
A
P
L
T
S
---------
L
T
V
P
E
L
T
Q
Q
M
F
D
S
K
N
M
M
A
A
C
D
P
-
R
H
G
R
Y
L
T
V
A
A
V
F
R
G
R
M
S
M
K
E
V
D
E
Q
M
L
N
V
Q
N
K
N
S
S
Y
F
V
E
W
I
P
N
N
V
K
T
A
V
C
D
I
P
P
-
R
G
--------
L
K
M
S
A
T
F
I
G
N
S
T
A
I
Q
E
L
F
K
R
I
S
E
Q
F
T
A
M
F
R
R
K
A
F
L
H
W
Y
T
G
E
G
M
D
E
M
E
F
T
E
A
---
E
S
N
M
N
D
L
V
S
E
Y
Q
Q
Y
Q
D
A
T
----------------
12
PsiBlast_PDB
89.75
99%
-85
- C2 -
-
3N2G
3
?
B:
[2-428]
-
R
E
I
V
H
I
Q
A
G
Q
C
G
N
Q
I
G
A
K
F
W
E
V
I
S
D
E
H
G
I
D
P
T
G
S
Y
H
G
D
S
D
L
Q
L
---
E
R
I
N
V
Y
Y
N
E
A
T
G
N
K
Y
V
P
R
A
I
L
V
D
L
E
P
G
T
M
D
S
V
R
S
G
P
F
G
Q
I
F
R
P
D
N
F
V
F
G
--
Q
S
G
A
G
N
N
W
A
K
G
H
Y
T
E
G
A
E
L
V
D
S
V
L
D
V
V
R
K
E
S
E
S
C
D
C
L
Q
G
F
Q
L
T
H
S
L
G
G
G
T
G
S
G
M
G
T
L
L
I
S
K
I
R
E
E
Y
P
D
R
I
M
N
T
F
S
V
M
P
S
P
K
-
V
S
D
T
V
V
E
P
Y
N
A
T
L
S
V
H
Q
L
V
E
N
T
D
E
T
Y
S
I
D
N
E
A
L
Y
D
I
C
F
R
T
L
K
L
T
T
P
T
Y
G
D
L
N
H
L
V
S
A
T
M
S
G
V
T
T
C
L
R
F
P
G
Q
L
N
A
D
L
R
K
L
A
V
N
M
V
P
F
P
R
L
H
F
F
M
P
G
F
A
P
L
T
S
---------
L
T
V
P
E
L
T
Q
Q
M
F
D
S
K
N
M
M
A
A
C
D
P
-
R
H
G
R
Y
L
T
V
A
A
V
F
R
G
R
M
S
M
K
E
V
D
E
Q
M
L
N
V
Q
N
K
N
S
S
Y
F
V
E
W
I
P
N
N
V
K
T
A
V
C
D
I
P
P
-
R
G
--------
L
K
M
S
A
T
F
I
G
N
S
T
A
I
Q
E
L
F
K
R
I
S
E
Q
F
T
A
M
F
R
R
K
A
F
L
H
W
Y
T
G
E
G
M
D
E
M
E
F
T
E
A
---
E
S
N
M
N
D
L
V
S
E
Y
Q
Q
Y
Q
D
A
-----------------
10
PsiBlast_PDB
89.36
99%
-79
- C2 -
-
3HKD
2
?
B:
[2-429]
-
R
E
I
V
H
I
Q
A
G
Q
C
G
N
Q
I
G
A
K
F
W
E
V
I
S
D
E
H
G
I
D
P
T
G
S
Y
H
G
D
S
D
L
Q
L
---
E
R
I
N
V
Y
Y
N
E
A
T
G
N
K
Y
V
P
R
A
I
L
V
D
L
E
P
G
T
M
D
S
V
R
S
G
P
F
G
Q
I
F
R
P
D
N
F
V
F
G
--
Q
S
G
A
G
N
N
W
A
K
G
H
Y
T
E
G
A
E
L
V
D
S
V
L
D
V
V
R
K
E
S
E
S
C
D
C
L
Q
G
F
Q
L
T
H
S
L
G
G
G
T
G
S
G
M
G
T
L
L
I
S
K
I
R
E
E
Y
P
D
R
I
M
N
T
F
S
V
M
P
S
P
K
-
V
S
D
T
V
V
E
P
Y
N
A
T
L
S
V
H
Q
L
V
E
N
T
D
E
T
Y
S
I
D
N
E
A
L
Y
D
I
C
F
R
T
L
K
L
T
T
P
T
Y
G
D
L
N
H
L
V
S
A
T
M
S
G
V
T
T
C
L
R
F
P
G
Q
L
N
A
D
L
R
K
L
A
V
N
M
V
P
F
P
R
L
H
F
F
M
P
G
F
A
P
L
T
S
---------
L
T
V
P
E
L
T
Q
Q
M
F
D
S
K
N
M
M
A
A
C
D
P
-
R
H
G
R
Y
L
T
V
A
A
V
F
R
G
R
M
S
M
K
E
V
D
E
Q
M
L
N
V
Q
N
K
N
S
S
Y
F
V
E
W
I
P
N
N
V
K
T
A
V
C
D
I
P
P
-
R
G
--------
L
K
M
S
A
T
F
I
G
N
S
T
A
I
Q
E
L
F
K
R
I
S
E
Q
F
T
A
M
F
R
R
K
A
F
L
H
W
Y
T
G
E
G
M
D
E
M
E
F
T
E
A
---
E
S
N
M
N
D
L
V
S
E
Y
Q
Q
Y
Q
D
A
T
----------------
19
PsiBlast_PDB
89.03
99%
-83
- C2 -
-
1Z2B
4
TBB2B_BOVIN
B:
[2-428]
-
R
E
I
V
H
I
Q
A
G
Q
C
G
N
Q
I
G
A
K
F
W
E
V
I
S
D
E
H
G
I
D
P
T
G
S
Y
H
G
D
S
D
L
Q
L
---
E
R
I
N
V
Y
Y
N
E
A
T
G
N
K
Y
V
P
R
A
I
L
V
D
L
E
P
G
T
M
D
S
V
R
S
G
P
F
G
Q
I
F
R
P
D
N
F
V
F
G
--
Q
S
G
A
G
N
N
W
A
K
G
H
Y
T
E
G
A
E
L
V
D
S
V
L
D
V
V
R
K
E
S
E
S
C
D
C
L
Q
G
F
Q
L
T
H
S
L
G
G
G
T
G
S
G
M
G
T
L
L
I
S
K
I
R
E
E
Y
P
D
R
I
M
N
T
F
S
V
V
P
S
P
K
-
V
S
D
T
V
V
E
P
Y
N
A
T
L
S
V
H
Q
L
V
E
N
T
D
E
T
Y
S
I
D
N
E
A
L
Y
D
I
C
F
R
T
L
K
L
T
T
P
T
Y
G
D
L
N
H
L
V
S
A
T
M
S
G
V
T
T
C
L
R
F
P
G
Q
L
N
A
D
L
R
K
L
A
V
N
M
V
P
F
P
R
L
H
F
F
M
P
G
F
A
P
L
T
S
---------
L
T
V
P
E
L
T
Q
Q
M
F
D
S
K
N
M
M
A
A
C
D
P
-
R
H
G
R
Y
L
T
V
A
A
V
F
R
G
R
M
S
M
K
E
V
D
E
Q
M
L
N
V
Q
N
K
N
S
S
Y
F
V
E
W
I
P
N
N
V
K
T
A
V
C
D
I
P
P
-
R
G
--------
L
K
M
S
A
T
F
I
G
N
S
T
A
I
Q
E
L
F
K
R
I
S
E
Q
F
T
A
M
F
R
R
K
A
F
L
H
W
Y
T
G
E
G
M
D
E
M
E
F
T
E
A
---
E
S
N
M
N
D
L
V
S
E
Y
Q
Q
Y
Q
D
A
-----------------
40
HHSearch
88.90
97%
-82
- C2 -
-
5N5N
1
TBB5_HUMAN
E:
[1-425]
M
R
E
I
V
H
I
Q
A
G
Q
C
G
N
Q
I
G
A
K
F
W
E
V
I
S
D
E
H
G
I
D
P
T
G
T
Y
H
G
D
S
D
L
Q
L
---
D
R
I
S
V
Y
Y
N
E
A
T
G
G
K
Y
V
P
R
A
I
L
V
D
L
E
P
G
T
M
D
S
V
R
S
G
P
F
G
Q
I
F
R
P
D
N
F
V
F
G
--
Q
S
G
A
G
N
N
W
A
K
G
H
Y
T
E
G
A
E
L
V
D
S
V
L
D
V
V
R
K
E
A
E
S
C
D
C
L
Q
G
F
Q
L
T
H
S
L
G
G
G
T
G
S
G
M
G
T
L
L
I
S
K
I
R
E
E
Y
P
D
R
I
M
N
T
F
S
V
V
P
S
P
K
-
V
S
D
T
V
V
E
P
Y
N
A
T
L
S
V
H
Q
L
V
E
N
T
D
E
T
Y
C
I
D
N
E
A
L
Y
D
I
C
F
R
T
L
K
L
T
T
P
T
Y
G
D
L
N
H
L
V
S
A
T
M
S
G
V
T
T
C
L
R
F
P
G
Q
L
N
A
D
L
R
K
L
A
V
N
M
V
P
F
P
R
L
H
F
F
M
P
G
F
A
P
L
T
S
R
G
S
Q
Q
-
Y
R
A
L
T
V
P
E
L
T
Q
Q
V
F
D
A
K
N
M
M
A
A
C
D
P
-
R
H
G
R
Y
L
T
V
A
A
V
F
R
G
R
M
S
M
K
E
V
D
E
Q
M
L
N
V
Q
N
K
N
S
S
Y
F
V
E
W
I
P
N
N
V
K
T
A
V
C
D
I
P
P
-
R
G
--------
L
K
M
A
V
T
F
I
G
N
S
T
A
I
Q
E
L
F
K
R
I
S
E
Q
F
T
A
M
F
R
R
K
A
F
L
H
W
Y
T
G
E
G
M
D
E
M
E
F
T
E
A
---
E
S
N
M
N
D
L
V
S
E
Y
Q
Q
Y
--------------------
8
PsiBlast_PDB
88.34
99%
-81
- C2 -
-
3HKB
2
?
B:
[2-429]
-
R
E
I
V
H
I
Q
A
G
Q
C
G
N
Q
I
G
A
K
F
W
E
V
I
S
D
E
H
G
I
D
P
T
G
S
Y
H
G
D
S
D
L
Q
L
---
E
R
I
N
V
Y
Y
N
E
A
T
G
N
K
Y
V
P
R
A
I
L
V
D
L
E
P
G
T
M
D
S
V
R
S
G
P
F
G
Q
I
F
R
P
D
N
F
V
F
G
--
Q
S
G
A
G
N
N
W
A
K
G
H
Y
T
E
G
A
E
L
V
D
S
V
L
D
V
V
R
K
E
S
E
S
C
D
C
L
Q
G
F
Q
L
T
H
S
L
G
G
G
T
G
S
G
M
G
T
L
L
I
S
K
I
R
E
E
Y
P
D
R
I
M
N
T
F
S
V
M
P
S
P
K
-
V
S
D
T
V
V
E
P
Y
N
A
T
L
S
V
H
Q
L
V
E
N
T
D
E
T
Y
S
I
D
N
E
A
L
Y
D
I
C
F
R
T
L
K
L
T
T
P
T
Y
G
D
L
N
H
L
V
S
A
T
M
S
G
V
T
T
C
L
R
F
P
G
Q
L
N
A
D
L
R
K
L
A
V
N
M
V
P
F
P
R
L
H
F
F
M
P
G
F
A
P
L
T
S
---------
L
T
V
P
E
L
T
Q
Q
M
F
D
S
K
N
M
M
A
A
C
D
P
-
R
H
G
R
Y
L
T
V
A
A
V
F
R
G
R
M
S
M
K
E
V
D
E
Q
M
L
N
V
Q
N
K
N
S
S
Y
F
V
E
W
I
P
N
N
V
K
T
A
V
C
D
I
P
P
-
R
G
--------
L
K
M
S
A
T
F
I
G
N
S
T
A
I
Q
E
L
F
K
R
I
S
E
Q
F
T
A
M
F
R
R
K
A
F
L
H
W
Y
T
G
E
G
M
D
E
M
E
F
T
E
A
---
E
S
N
M
N
D
L
V
S
E
Y
Q
Q
Y
Q
D
A
T
----------------
11
PsiBlast_PDB
87.49
99%
-83
- C2 -
-
3HKE
4
?
B:
[2-429]
-
R
E
I
V
H
I
Q
A
G
Q
C
G
N
Q
I
G
A
K
F
W
E
V
I
S
D
E
H
G
I
D
P
T
G
S
Y
H
G
D
S
D
L
Q
L
---
E
R
I
N
V
Y
Y
N
E
A
T
G
N
K
Y
V
P
R
A
I
L
V
D
L
E
P
G
T
M
D
S
V
R
S
G
P
F
G
Q
I
F
R
P
D
N
F
V
F
G
--
Q
S
G
A
G
N
N
W
A
K
G
H
Y
T
E
G
A
E
L
V
D
S
V
L
D
V
V
R
K
E
S
E
S
C
D
C
L
Q
G
F
Q
L
T
H
S
L
G
G
G
T
G
S
G
M
G
T
L
L
I
S
K
I
R
E
E
Y
P
D
R
I
M
N
T
F
S
V
M
P
S
P
K
-
V
S
D
T
V
V
E
P
Y
N
A
T
L
S
V
H
Q
L
V
E
N
T
D
E
T
Y
S
I
D
N
E
A
L
Y
D
I
C
F
R
T
L
K
L
T
T
P
T
Y
G
D
L
N
H
L
V
S
A
T
M
S
G
V
T
T
C
L
R
F
P
G
Q
L
N
A
D
L
R
K
L
A
V
N
M
V
P
F
P
R
L
H
F
F
M
P
G
F
A
P
L
T
S
---------
L
T
V
P
E
L
T
Q
Q
M
F
D
S
K
N
M
M
A
A
C
D
P
-
R
H
G
R
Y
L
T
V
A
A
V
F
R
G
R
M
S
M
K
E
V
D
E
Q
M
L
N
V
Q
N
K
N
S
S
Y
F
V
E
W
I
P
N
N
V
K
T
A
V
C
D
I
P
P
-
R
G
--------
L
K
M
S
A
T
F
I
G
N
S
T
A
I
Q
E
L
F
K
R
I
S
E
Q
F
T
A
M
F
R
R
K
A
F
L
H
W
Y
T
G
E
G
M
D
E
M
E
F
T
E
A
---
E
S
N
M
N
D
L
V
S
E
Y
Q
Q
Y
Q
D
A
T
----------------
6
PsiBlast_PDB
87.31
99%
-80
- C2 -
-
3DU7
3
TBB2B_BOVIN
B:
[2-427]
-
R
E
I
V
H
I
Q
A
G
Q
C
G
N
Q
I
G
A
K
F
W
E
V
I
S
D
E
H
G
I
D
P
T
G
S
Y
H
G
D
S
D
L
Q
L
---
E
R
I
N
V
Y
Y
N
E
A
T
G
N
K
Y
V
P
R
A
I
L
V
D
L
E
P
G
T
M
D
S
V
R
S
G
P
F
G
Q
I
F
R
P
D
N
F
V
F
G
--
Q
S
G
A
G
N
N
W
A
K
G
H
Y
T
E
G
A
E
L
V
D
S
V
L
D
V
V
R
K
E
S
E
S
C
D
C
L
Q
G
F
Q
L
T
H
S
L
G
G
G
T
G
S
G
M
G
T
L
L
I
S
K
I
R
E
E
Y
P
D
R
I
M
N
T
F
S
V
M
P
S
P
K
-
V
S
D
T
V
V
E
P
Y
N
A
T
L
S
V
H
Q
L
V
E
N
T
D
E
T
Y
S
I
D
N
E
A
L
Y
D
I
C
F
R
T
L
K
L
T
T
P
T
Y
G
D
L
N
H
L
V
S
A
T
M
S
G
V
T
T
C
L
R
F
P
G
Q
L
N
A
D
L
R
K
L
A
V
N
M
V
P
F
P
R
L
H
F
F
M
P
G
F
A
P
L
T
S
R
G
S
Q
Q
-
Y
R
A
L
T
V
P
E
L
T
Q
Q
M
F
D
S
K
N
M
M
A
A
C
D
P
-
R
H
G
R
Y
L
T
V
A
A
V
F
R
G
R
M
S
M
K
E
V
D
E
Q
M
L
N
V
Q
N
K
N
S
S
Y
F
V
E
W
I
P
N
N
V
K
T
A
V
C
D
I
P
P
-
R
G
--------
L
K
M
S
A
T
F
I
G
N
S
T
A
I
Q
E
L
F
K
R
I
S
E
Q
F
T
A
M
F
R
R
K
A
F
L
H
W
Y
T
G
E
G
M
D
E
M
E
F
T
E
A
---
E
S
N
M
N
D
L
V
S
E
Y
Q
Q
Y
Q
D
------------------
47
HHSearch
72.44
42%
-83
- C2 -
-
5ND4
1
TBA1B_BOVIN
A:
[1-410]
-
R
E
C
I
S
I
H
V
G
Q
A
G
V
Q
I
G
N
A
C
W
E
L
Y
C
L
E
H
G
I
Q
P
---------------------------
D
G
H
V
P
R
A
V
F
V
D
L
E
P
T
V
I
D
E
V
R
T
G
T
Y
R
Q
L
F
H
P
E
Q
L
I
T
G
--
K
E
D
A
A
N
N
Y
A
R
G
H
Y
T
I
G
K
E
I
I
D
L
V
L
D
R
I
R
K
L
A
D
Q
C
T
G
L
Q
G
F
S
V
F
H
S
F
G
G
G
T
G
S
G
F
T
S
L
L
M
E
R
L
S
V
D
Y
G
K
K
S
K
L
E
F
S
I
Y
P
A
P
Q
-
V
S
T
A
V
V
E
P
Y
N
S
I
L
T
T
H
T
T
L
E
H
S
D
C
A
F
M
V
D
N
E
A
I
Y
D
I
C
R
R
N
L
D
I
E
R
P
T
Y
T
N
L
N
R
L
I
G
Q
I
V
S
S
I
T
A
S
L
R
F
D
G
A
L
N
V
D
L
T
E
F
Q
T
N
L
V
P
Y
P
R
G
H
F
P
L
A
T
Y
A
P
V
I
S
A
E
K
A
Y
-
H
E
Q
L
S
V
A
E
I
T
N
A
C
F
E
P
A
N
Q
M
V
K
C
D
P
-
R
H
G
K
Y
M
A
C
C
L
L
Y
R
G
D
V
V
P
K
D
V
N
A
A
I
A
T
I
K
T
K
R
T
I
Q
F
V
D
W
C
P
T
G
F
K
V
G
I
N
Y
E
P
P
-
T
V
VPGGDLAK
V
Q
R
A
V
C
M
L
S
N
T
T
A
I
A
E
A
W
A
R
L
D
H
K
F
D
L
M
Y
A
K
R
A
F
V
H
W
Y
V
G
E
G
M
E
E
G
E
F
S
E
A
---
R
E
D
M
A
A
L
E
K
D
Y
E
E
V
G
V
------------------
21
Fugue
70.88
99%
4
- C2 -
-
1TUB
3
TBB_PIG
B:
[1-427]
M
R
E
I
V
H
I
Q
A
G
Q
C
G
N
Q
I
G
A
K
F
W
E
V
I
S
D
E
H
G
I
D
P
T
G
S
Y
H
G
D
S
D
L
Q
L
ERI---
N
V
Y
Y
N
E
A
A
G
N
K
Y
V
P
R
A
I
L
V
D
L
E
P
G
T
M
D
S
V
R
S
G
P
F
G
Q
I
F
R
P
D
N
F
V
F
G
--
Q
S
G
A
G
N
N
W
A
K
G
H
Y
T
E
G
A
E
L
V
D
S
V
L
D
V
V
R
K
E
S
E
S
C
D
C
L
Q
G
F
Q
L
T
H
S
L
G
G
G
T
G
S
G
M
G
T
L
L
I
S
K
I
R
E
E
Y
P
D
R
I
M
N
T
F
S
V
V
P
S
P
K
-
V
S
D
T
V
V
E
P
Y
N
A
T
L
S
V
H
Q
L
V
E
N
T
D
E
T
Y
C
I
D
N
E
A
L
Y
D
I
C
F
R
T
L
K
L
T
T
P
T
Y
G
D
L
N
H
L
V
S
A
T
M
S
G
V
T
T
C
L
R
F
P
G
Q
L
N
A
D
L
R
K
L
A
V
N
M
V
P
F
P
R
L
H
F
F
M
P
G
F
A
P
L
T
S
R
G
S
Q
Q
-
Y
R
A
L
T
V
P
E
L
T
Q
Q
M
F
D
A
K
N
M
M
A
A
C
D
P
-
R
H
G
R
Y
L
T
V
A
A
V
F
R
G
R
M
S
M
K
E
V
D
E
Q
M
L
N
V
Q
N
K
N
S
S
Y
F
V
E
W
I
P
N
N
V
K
T
A
V
C
D
I
P
P
-
R
G
--------
L
K
M
S
A
T
F
I
G
N
S
T
A
I
Q
E
L
F
K
R
I
S
E
Q
F
T
A
M
F
R
R
K
A
F
L
H
W
Y
T
G
E
G
M
D
E
M
E
F
T
E
A
---
E
S
N
M
N
D
L
V
S
E
Y
Q
Q
Y
Q
D
------------------
41
HHSearch
58.78
34%
-1
- C2 -
-
3CB2
1
TBG1_HUMAN
A:
[2-445]
P
R
E
I
I
T
L
Q
L
G
Q
C
G
N
Q
I
G
F
E
F
W
K
Q
L
C
A
E
H
G
I
S
P
E
A
I
V
E
E
F
A
T
E
G
T
---
D
R
K
D
V
F
F
Y
Q
A
D
D
E
H
Y
I
P
R
A
V
L
L
D
L
E
P
R
V
I
H
S
I
L
N
S
P
Y
A
K
L
Y
N
P
E
N
I
Y
L
S
EH
G
G
G
A
G
N
N
W
A
S
G
F
S
-
Q
G
E
K
I
H
E
D
I
F
D
I
I
D
R
E
A
D
G
S
D
S
L
E
G
F
V
L
C
H
S
I
A
G
G
T
G
S
G
L
G
S
Y
L
L
E
R
L
N
D
R
Y
P
K
K
L
V
Q
T
Y
S
V
F
P
N
Q
D
E
M
S
D
V
V
V
Q
P
Y
N
S
L
L
T
L
K
R
L
T
Q
N
A
D
C
L
V
V
L
D
N
T
A
L
N
R
I
A
T
D
R
L
H
I
Q
N
P
S
F
S
Q
I
N
Q
L
V
S
T
I
M
S
A
S
T
T
T
L
R
Y
P
G
Y
M
N
N
D
L
I
G
L
I
A
S
L
I
P
T
P
R
L
H
F
L
M
T
G
Y
T
P
L
T
------S
V
R
K
T
T
V
L
D
V
M
R
R
L
L
Q
P
K
N
V
M
V
S
T
G
R
D
T
N
H
C
Y
I
A
I
L
N
I
I
Q
G
E
V
D
P
T
Q
V
H
K
S
L
Q
R
I
R
E
R
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A
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W
G
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I
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V
A
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S
P
Y-----------
R
V
S
G
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M
M
A
N
H
T
S
I
S
S
L
F
E
R
T
C
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R
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-------------