@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : HSP76_HUMAN: (2018-10-03 )
MQAPRELAVGIDLGTTYSCVGVFQQGRVEILANDQGNRTTPSYVAFTDTERLVGDAAKSQAALNPHNTVFDAKRLIGRKFADTTVQSDMKHWPFRVVSEGGKPKVRVCYRGEDKTFYPEEISSMVLSKMKETAEAYLGQPVKHAVITVPAYFNDSQRQATKDAGAIAGLNVLRIINEPTAAAIAYGLDRRGAGERNVLIFDLGGGTFDVSVLSIDAGVFEVKATAGDTHLGGEDFDNRLVNHFMEEFRRKHGKDLSGNKRALRRLRTACERAKRTLSSSTQATLEIDSLFEGVDFYTSITRARFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDVVLVGGSTRIPKVQKLLQDFFNGKELNKSINPDEAVAYGAAVQAAVLMGDKCEKVQDLLLLDVAPLSLGLETAGGVMTTLIQRNATIPTKQTQTFTTYSDNQPGVFIQVYEGERAMTKDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILSVTATDRSTGKANKITITNDKGRLSKEEVERMVHEAEQYKAEDEAQRDRVAAKNSLEAHVFHVKGSLQEESLRDKIPEEDRRKMQDKCREVLAWLEHNQLAEKEEYEHQKRELEQICRPIFSRLYGGPGVPGGSSCGTQARQGDPSTGPIIEEVD
Atome Classification :
(26 SA)
.........10........20........30........40......-.-.-50........60........70........80........90........100......-..110........120.......130.......140.......150.......160.......170.......180.......190--........200.......210....----...220.......230.......240.......250.......260.......270.......280.......290---.----.......300.......310.......320.......330.......340.......350.......360.......370.......380.....-..390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550...-..-..560.......570.......580.......590.......600.......610.......620.......630.......640.
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MQAP
R
E
L
A
V
G
IDLGT
T
Y
S
C
V
G
V
F
QQG
R
V
E
I
L
ANDQGNRTT
P
S
Y
V
A
FT-
D
-
T
-
E
R
L
V
G
D
AAKSQAALNPH
N
T
V
F
D
A
K
R
L
IG
R
K
F
A
D
T
T
V
Q
S
DMKHW
P
F
R
V
VSEG-GK
P
K
V
R
V
-
C
YR-GEDKTF
Y
P
E
E
I
S
S
M
V
L
S
K
M
K
E
T
A
E
A
Y
LGQPV
K
H
A
V
I
T
V
P
A
YFND
S
Q
R
Q
A
TKDA
G
A
I
A
G
L
N
V
L
R
IINEP
T
A
A
A
I
A
YGLDRR-G--AGER
N
V
L
I
F
DLGG
G
T
F
D
V
S
V
L
S
IDA----
G
V
F
E
V
K
ATAGDTHLGG
E
D
F
D
N
R
L
V
N
H
F
M
E
E
F
R
R
KHGKDLSG
N
K
R
A
L
R
R
L
R
T
A
C
E
R
A
K
R
T
LSSST
Q
A
T
L
E
I
D
S
L
FE----
G
----
V
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
R
S
T
L
E
P
V
E
K
A
L
R
DAKLDK
A
Q
I
H
D
V
V
L
VGGSTR
I
P
K
V
Q
K
L
L
Q
D
F
F
N
G
K
E
LNKSI
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
V
LMG
D
K
C
-
E
K
V
Q
D
L
L
L
L
DVAPLSLGLETA
G
G
V
M
T
T
L
I
QRNATIPTKQ
T
Q
T
F
T
T
YSDNQP
G
V
F
I
Q
V
YEGERAMTKDN
N
L
L
G
R
F
ELSGIPPAPRGV
P
Q
I
E
V
T
F
DIDAN
G
I
L
S
V
T
ATDRSTGKA
N
K
I
T
I
TNDKGRL
S
K
E
E
V
E
R
M
V
H
E
A
E
Q
YKAE
D
E
A
Q
R
D
R
V
A
AKNSL
E
A
H
V
F
H
VKGSL-
Q
E
-
E
S
L
R
D
KI
P
E
E
D
R
R
K
M
Q
D
K
C
R
E
V
L
A
W
L
E
H
N
QL
A
E
K
E
E
Y
E
H
Q
K
R
E
L
E
Q
I
C
R
P
I
F
S
R
LYGGPGVPGGSSCGTQARQGDPSTGPIIEEVD
2
PsiBlast_PDB
90.83
82%
-69
- C2 -
-
4FL9
3
HSP7C_BOVIN
A:
[6-553]
-------
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
-
D
-
T
-
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
V
V
Q
S
D
M
K
H
W
P
F
M
V
V
N
D
A
-
G
R
P
K
V
Q
V
-
E
Y
K
-
G
E
T
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
K
-
V
--
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
A
A
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
----
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
------------
D
V
T
P
L
S
L
G
I
E
T
A
G
G
V
M
T
V
L
I
K
R
N
T
T
I
P
T
K
Q
T
Q
T
F
T
T
Y
S
D
N
Q
P
G
V
L
I
Q
V
Y
E
G
E
R
A
M
T
K
D
N
N
L
L
G
K
F
E
L
T
G
I
P
P
A
P
R
G
V
P
Q
I
E
V
T
F
D
I
D
A
N
G
I
L
N
V
S
A
V
D
K
S
T
G
K
E
N
K
I
T
I
T
N
D
K
G
R
L
S
K
E
D
I
E
R
M
V
Q
E
A
E
K
Y
K
A
E
D
E
K
Q
R
D
K
V
S
S
K
N
S
L
E
S
Y
A
F
N
M
K
A
T
V
------------------------------------------------------------------------------------------
1
PsiBlast_PDB
88.60
82%
-63
- C2 -
-
1YUW
-
HSP7C_BOVIN
A:
[6-554]
-------
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
-
D
-
T
-
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
V
V
Q
S
D
M
K
H
W
P
F
M
V
V
N
D
A
-
G
R
P
K
V
Q
V
-
E
Y
K
-
G
E
T
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
K
-
V
--
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
A
A
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
----
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
K
S
-
E
N
V
Q
D
L
L
L
L
D
V
T
P
L
S
L
G
I
E
T
A
G
G
V
M
T
V
L
I
K
R
N
T
T
I
P
T
K
Q
T
Q
T
F
T
T
Y
S
D
N
Q
P
G
V
L
I
Q
V
Y
E
G
E
R
A
M
T
K
D
N
N
L
L
G
K
F
E
L
T
G
I
P
P
A
P
R
G
V
P
Q
I
E
V
T
F
D
I
D
A
N
G
I
L
N
V
S
A
V
D
K
S
T
G
K
E
N
K
I
T
I
T
N
D
K
G
R
L
S
K
E
D
I
E
R
M
V
Q
E
A
E
K
Y
K
A
E
D
E
K
Q
R
D
K
V
S
S
K
N
S
L
E
S
Y
A
F
N
M
K
A
T
V
-
E
----------------------------------------------------------------------------------------
45
HHSearch
88.40
82%
-62
- C2 -
-
1YUW
-
HSP7C_BOVIN
A:
[2-553]
---
S
K
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
-
D
-
T
-
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
V
V
Q
S
D
M
K
H
W
P
F
M
V
V
N
D
A
-
G
R
P
K
V
Q
V
-
E
Y
K
-
G
E
T
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
K
-
V
--
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
A
A
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
----
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
K
S
-
E
N
V
Q
D
L
L
L
L
D
V
T
P
L
S
L
G
I
E
T
A
G
G
V
M
T
V
L
I
K
R
N
T
T
I
P
T
K
Q
T
Q
T
F
T
T
Y
S
D
N
Q
P
G
V
L
I
Q
V
Y
E
G
E
R
A
M
T
K
D
N
N
L
L
G
K
F
E
L
T
G
I
P
P
A
P
R
G
V
P
Q
I
E
V
T
F
D
I
D
A
N
G
I
L
N
V
S
A
V
D
K
S
T
G
K
E
N
K
I
T
I
T
N
D
K
G
R
L
S
K
E
D
I
E
R
M
V
Q
E
A
E
K
Y
K
A
E
D
E
K
Q
R
D
K
V
S
S
K
N
S
L
E
S
Y
A
F
N
M
K
A
T
V
------------------------------------------------------------------------------------------
3
PsiBlast_PDB
88.21
82%
-70
- C2 -
-
3C7N
2
HSP7C_BOVIN
B:
[6-547]
-------
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
-
D
-
T
-
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
V
V
Q
S
D
M
K
H
W
P
F
M
V
V
N
D
A
-
G
R
P
K
V
Q
V
-
E
Y
K
-
G
E
T
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
K
-
V
--
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
E
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
----
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
K
------
D
L
L
L
L
D
V
T
P
L
S
L
G
I
E
T
A
G
G
V
M
T
V
L
I
K
R
N
T
T
I
P
T
K
Q
T
Q
T
F
T
T
Y
S
D
N
Q
P
G
V
L
I
Q
V
Y
E
G
E
R
A
M
T
K
D
N
N
L
L
G
K
F
E
L
T
G
I
P
P
A
P
R
G
V
P
Q
I
E
V
T
F
D
I
D
A
N
G
I
L
N
V
S
A
V
D
K
S
T
G
K
E
N
K
I
T
I
T
N
D
K
G
R
L
S
K
E
D
I
E
R
M
V
Q
E
A
E
K
Y
K
A
E
D
E
K
Q
R
D
K
V
S
S
K
N
S
L
E
S
Y
A
F
------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
85.09
100%
-91
- C2 -
-
3FE1
1
HSP76_HUMAN
A:
[24-403]
-----
E
L
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
Q
G
R
V
E
I
L
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
-
D
-
T
-
E
R
L
V
G
D
A
A
K
S
Q
A
A
L
N
P
H
N
T
V
F
D
A
K
R
L
I
G
R
K
F
A
D
T
T
V
Q
S
D
M
K
H
W
P
F
R
V
V
S
E
G
-
G
K
P
K
V
R
V
-
C
Y
R
-
G
E
D
K
T
F
Y
P
E
E
I
S
S
M
V
L
S
K
M
K
E
T
A
E
A
Y
L
G
Q
P
V
K
H
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
A
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
R
R
-
G
--
A
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
V
L
S
I
D
A
----
G
V
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
M
E
E
F
R
R
K
H
G
K
D
L
S
G
N
K
R
A
L
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
Q
A
T
L
E
I
D
S
L
F
E
----
G
----
V
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
V
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
N
G
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
V
L
M
G
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
82.71
87%
-90
- C2 -
-
2E8A
1
HS71A_HUMAN
A:
[9-385]
-------
A
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
-
D
-
T
-
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
T
V
F
D
A
K
R
L
I
G
R
K
F
G
D
P
V
V
Q
S
D
M
K
H
W
P
F
Q
V
I
N
D
G
-
D
K
P
K
V
Q
V
-
S
Y
K
-
G
E
T
K
A
F
Y
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
R
T
-
G
--
K
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
D
D
----
G
I
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
Q
A
S
L
E
I
D
S
L
F
E
----
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
N
G
R
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
HHSearch
82.60
86%
-93
- C2 -
-
4J8F
1
F10A1_RAT (first)
A:
[7-389]
-
F
M
A
K
A
A
A
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
-
D
-
T
-
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
T
V
F
D
A
K
R
L
I
G
R
K
F
G
D
P
V
V
Q
S
D
M
K
H
W
P
F
Q
V
I
N
D
G
-
D
K
P
K
V
Q
V
-
S
Y
K
-
G
E
T
K
A
F
Y
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
R
T
-
G
--
K
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
D
D
----
G
I
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
Q
A
S
L
E
I
D
S
L
F
E
----
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
N
G
R
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
82.56
87%
-98
- C2 -
-
3A8Y
1
HS71A_HUMAN
A:
[10-387]
-------
A
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
-
D
-
T
-
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
T
V
F
D
A
K
R
L
I
G
R
K
F
G
D
P
V
V
Q
S
D
M
K
H
W
P
F
Q
V
I
N
D
G
-
D
K
P
K
V
Q
V
-
S
Y
K
-
G
E
T
K
A
F
Y
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
R
T
-
G
--
K
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
D
D
----
G
I
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
Q
A
S
L
E
I
D
S
L
F
E
----
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
N
G
R
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
G
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
82.32
87%
-91
- C2 -
-
5BN9
2
HS71A_HUMAN
A:
[6-382]
-------
A
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
-
D
-
T
-
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
T
V
F
D
A
K
R
L
I
G
R
K
F
G
D
P
V
V
Q
S
D
M
K
H
W
P
F
Q
V
I
N
D
G
-
D
K
P
K
V
Q
V
-
S
Y
K
-
G
E
T
K
A
F
Y
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
R
T
-
G
--
K
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
D
D
----
G
I
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
K
T
L
S
S
S
T
Q
A
S
L
E
I
D
S
L
F
E
----
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
N
G
R
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
82.30
87%
-89
- C2 -
-
3ATV
1
HS71A_HUMAN
A:
[10-386]
-------
A
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
-
D
-
T
-
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
T
V
F
D
A
K
R
L
I
G
R
K
F
G
D
P
V
V
Q
S
D
M
K
H
W
P
F
Q
V
I
N
D
G
-
D
K
P
K
V
Q
V
-
S
Y
K
-
G
E
T
K
A
F
Y
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
R
T
-
G
--
K
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
D
D
----
G
I
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
Q
A
S
L
E
I
D
S
L
F
E
----
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
N
G
R
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
82.24
87%
-89
- C2 -
-
3AY9
1
HS71A_HUMAN
A:
[10-386]
-------
A
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
-
D
-
T
-
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
T
V
F
D
A
K
R
L
I
G
R
K
F
G
D
P
V
V
Q
S
D
M
K
H
W
P
F
Q
V
I
N
D
G
-
D
K
P
K
V
Q
V
-
S
Y
K
-
G
E
T
K
A
F
Y
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
R
T
-
G
--
K
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
D
D
----
G
I
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
Q
A
S
L
E
I
D
S
L
F
E
----
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
N
G
R
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
82.01
87%
-93
- C2 -
-
2E88
-
HS71A_HUMAN
A:
[9-386]
-------
A
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
-
D
-
T
-
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
T
V
F
D
A
K
R
L
I
G
R
K
F
G
D
P
V
V
Q
S
D
M
K
H
W
P
F
Q
V
I
N
D
G
-
D
K
P
K
V
Q
V
-
S
Y
K
-
G
E
T
K
A
F
Y
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
R
T
-
G
--
K
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
D
D
----
G
I
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
Q
A
S
L
E
I
D
S
L
F
E
----
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
N
G
R
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
G
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
81.97
87%
-87
- C2 -
-
3ATU
2
HS71A_HUMAN
A:
[10-386]
-------
A
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
-
D
-
T
-
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
T
V
F
D
A
K
R
L
I
G
R
K
F
G
D
P
V
V
Q
S
D
M
K
H
W
P
F
Q
V
I
N
D
G
-
D
K
P
K
V
Q
V
-
S
Y
K
-
G
E
T
K
A
F
Y
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
R
T
-
G
--
K
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
D
D
----
G
I
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
Q
A
S
L
E
I
D
S
L
F
E
----
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
N
G
R
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
81.88
87%
-90
- C2 -
-
5BN8
1
HS71A_HUMAN
A:
[6-382]
-------
A
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
-
D
-
T
-
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q
N
T
V
F
D
A
K
R
L
I
G
R
K
F
G
D
P
V
V
Q
S
D
M
K
H
W
P
F
Q
V
I
N
D
G
-
D
K
P
K
V
Q
V
-
S
Y
K
-
G
E
T
K
A
F
Y
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
R
T
-
G
--
K
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
D
D
----
G
I
F
E
V
K
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
Q
A
S
L
E
I
D
S
L
F
E
----
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
F
N
G
R
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
HHSearch
80.97
83%
-87
- C2 -
-
1QQM
1
HSP7C_BOVIN
A:
[2-376]
------
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
-
D
-
T
-
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
V
V
Q
S
D
M
K
H
W
P
F
M
V
V
N
D
A
-
G
A
P
K
V
Q
V
-
E
Y
K
-
G
E
T
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
A
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
A
-
V
--
G
A
E
R
N
V
L
I
F
S
L
G
G
G
T
F
D
V
S
I
L
T
I
E
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
A
H
A
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
----
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
80.70
83%
-89
- C2 -
-
2V7Z
1
HSP7C_RAT
A:
[6-382]
-------
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
-
D
-
T
-
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
V
F
D
A
K
R
L
I
G
R
R
F
D
D
A
V
V
Q
S
D
M
K
H
W
P
F
M
V
V
N
D
A
-
G
R
P
K
V
Q
V
-
E
Y
K
-
G
E
T
K
S
F
Y
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
A
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
K
-
V
--
R
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
T
E
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
----
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
78.75
57%
-6
- C2 -
-
5TKY
2
SSB1_CHATD
A:
[11-619]
--
E
V
Y
D
G
A
I
G
I
D
L
G
T
T
Y
S
C
V
A
V
Y
E
G
T
N
V
E
I
I
A
N
E
Q
G
N
F
T
T
P
S
F
V
S
F
T
-
E
-
N
-
C
R
L
I
G
E
A
A
K
N
Q
A
A
M
N
P
A
N
T
I
F
D
V
K
R
L
I
G
R
R
F
D
D
P
T
V
K
K
D
M
E
S
W
P
F
K
V
V
D
D
N
-
G
N
P
K
V
E
V
-
Q
Y
L
-
G
Q
T
H
T
F
S
P
Q
E
I
S
A
M
V
L
T
K
M
K
E
I
A
E
T
K
L
G
K
K
V
E
K
A
V
I
T
V
P
A
Y
F
N
D
N
Q
R
Q
A
T
K
D
A
G
A
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
G
S
G
K
S
--
D
K
E
R
N
V
L
I
Y
D
L
G
G
G
A
F
D
V
S
L
L
N
I
Q
G
----
G
V
F
T
V
K
A
T
A
G
D
T
H
L
G
G
Q
D
F
D
T
N
L
L
E
Y
C
K
K
E
F
T
R
K
T
K
K
D
L
S
G
D
A
R
A
L
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
G
A
Q
T
T
I
E
I
D
S
L
F
D
----
G
----
E
D
F
N
I
Q
I
T
R
A
R
F
E
D
L
N
A
K
A
F
A
G
T
L
E
P
V
A
Q
V
L
K
D
A
G
I
E
K
H
Q
V
D
E
I
V
L
V
G
G
S
T
R
I
P
R
I
Q
K
L
L
S
E
F
F
D
G
K
K
L
E
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
I
L
S
G
K
A
T
S
A
D
--
D
L
L
L
L
D
V
V
P
L
S
L
G
V
A
M
E
G
N
I
F
A
P
V
V
P
R
G
Q
T
V
P
T
I
K
K
R
T
F
T
T
V
A
D
N
Q
Q
T
V
Q
F
P
V
Y
Q
G
E
R
V
N
C
E
D
N
T
L
L
G
E
F
T
L
A
P
I
P
P
M
K
A
G
E
P
V
L
E
V
V
F
E
V
D
V
N
G
I
L
K
V
T
A
T
E
K
T
S
G
R
S
A
N
I
T
I
A
N
S
V
G
K
L
S
T
D
E
I
E
K
M
I
S
D
A
E
K
F
K
S
K
C
E
A
F
S
K
R
F
E
A
K
Q
Q
L
E
S
Y
I
S
R
V
E
E
I
I
-
S
D
------------
K
D
K
I
E
Q
A
L
S
E
A
M
A
Q
L
E
I
E
D
S
-
T
A
D
E
L
K
K
K
E
L
A
L
K
R
L
V
T
K
A
M
A
---------------------------------
39
HHSearch
77.83
57%
-2
- C2 -
-
5TKY
2
SSB1_CHATD
B:
[11-619]
--
E
V
Y
D
G
A
I
G
I
D
L
G
T
T
Y
S
C
V
A
V
Y
E
G
T
N
V
E
I
I
A
N
E
Q
G
N
F
T
T
P
S
F
V
S
F
T
-
E
-
N
-
C
R
L
I
G
E
A
A
K
N
Q
A
A
M
N
P
A
N
T
I
F
D
V
K
R
L
I
G
R
R
F
D
D
P
T
V
K
K
D
M
E
S
W
P
F
K
V
V
D
D
N
-
G
N
P
K
V
E
V
-
Q
Y
L
-
G
Q
T
H
T
F
S
P
Q
E
I
S
A
M
V
L
T
K
M
K
E
I
A
E
T
K
L
G
K
K
V
E
K
A
V
I
T
V
P
A
Y
F
N
D
N
Q
R
Q
A
T
K
D
A
G
A
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
G
S
G
K
S
--
D
K
E
R
N
V
L
I
Y
D
L
G
G
G
A
F
D
V
S
L
L
N
I
Q
G
----
G
V
F
T
V
K
A
T
A
G
D
T
H
L
G
G
Q
D
F
D
T
N
L
L
E
Y
C
K
K
E
F
T
R
K
T
K
K
D
L
S
G
D
A
R
A
L
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
G
A
Q
T
T
I
E
I
D
S
L
F
D
----
G
----
E
D
F
N
I
Q
I
T
R
A
R
F
E
D
L
N
A
K
A
F
A
G
T
L
E
P
V
A
Q
V
L
K
D
A
G
I
E
K
H
Q
V
D
E
I
V
L
V
G
G
S
T
R
I
P
R
I
Q
K
L
L
S
E
F
F
D
G
K
K
L
E
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
I
L
S
G
K
----
D
T
S
D
L
L
L
L
D
V
V
P
L
S
L
G
V
A
M
E
G
N
I
F
A
P
V
V
P
R
G
Q
T
V
P
T
I
K
K
R
T
F
T
T
V
A
----
T
V
Q
F
P
V
Y
Q
G
E
R
V
N
C
E
D
N
T
L
L
G
E
F
T
L
A
P
I
P
P
M
K
A
G
E
P
V
L
E
V
V
F
E
V
D
V
N
G
I
L
K
V
T
A
T
E
K
T
S
G
R
S
A
N
I
T
I
A
N
S
V
G
K
L
S
T
D
E
I
E
K
M
I
S
D
A
E
K
F
K
S
K
C
E
A
F
S
K
R
F
E
A
K
Q
Q
L
E
S
Y
I
S
R
V
E
E
I
I
-
S
-----------
G
Q
K
D
K
I
E
Q
A
L
S
E
A
M
A
Q
L
E
I
E
D
S
-
T
A
D
E
L
K
K
K
E
L
A
L
K
R
L
V
T
K
A
M
A
---------------------------------
57
HHSearch
73.74
84%
-18
* C2 *
-
3I33
2
HSP72_HUMAN
A:
[23-401]
-----
M
P
A
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
T
-
D
-
T
-
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T
N
T
I
F
D
A
K
R
L
I
G
R
K
F
E
D
A
T
V
Q
S
D
M
K
H
W
P
F
R
V
V
S
E
G
-
G
K
P
K
V
Q
V
-
E
Y
K
-
G
E
T
K
T
F
F
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
G
K
V
H
S
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
T
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
K
-
G
CA
G
G
E
K
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
E
D
----
G
I
F
E
V
K
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
S
H
L
A
E
E
F
K
R
K
H
K
K
D
I
G
P
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
T
Q
A
S
I
E
I
D
S
L
Y
E
----
G
----
V
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
R
G
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
G
Q
I
Q
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
72.19
61%
27
- C2 -
-
6ASY
6
BIP_HUMAN
A:
[7-606]
-------
V
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
K
N
G
R
V
E
I
I
A
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
T
P
E
-
G
-
E
R
L
I
G
D
A
A
K
N
Q
L
T
S
N
P
E
N
T
V
F
D
A
K
R
L
I
G
R
T
W
N
D
P
S
V
Q
Q
D
I
K
F
L
P
F
K
V
V
E
K
K
-
T
K
P
Y
I
Q
V
D
I
G
G
-
G
Q
T
K
T
F
A
P
E
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
R
----
E
G
E
K
N
I
L
V
F
D
L
G
G
G
T
F
D
V
S
L
L
T
I
D
N
----
G
V
F
E
V
V
A
T
N
G
D
T
H
L
G
G
E
D
F
D
Q
R
V
M
E
H
F
I
K
L
Y
K
K
K
T
G
K
D
V
R
K
D
N
R
A
V
Q
K
L
R
R
E
V
E
K
A
K
R
A
L
S
S
Q
H
Q
A
R
I
E
I
E
S
F
Y
E
----
G
----
E
D
F
S
E
T
L
T
R
A
K
F
E
E
L
N
M
D
L
F
R
S
T
M
K
P
V
Q
K
V
L
E
D
S
D
L
K
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
E
F
F
N
G
K
E
P
S
R
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
G
D
---
Q
D
T
G
D
L
V
L
L
D
V
C
P
L
T
L
G
I
E
T
V
G
G
V
M
T
K
L
I
P
R
N
T
V
V
P
T
K
K
S
Q
I
F
S
V
G
G
T
----
V
T
I
K
V
Y
E
G
E
R
P
L
T
K
D
N
H
L
L
G
T
F
D
L
T
G
I
P
P
A
P
R
G
V
P
Q
I
E
V
T
F
E
I
D
V
N
G
I
L
R
V
T
A
E
D
K
G
T
G
N
K
N
K
I
T
I
T
N
D
Q
N
R
L
T
P
E
E
I
E
R
M
V
N
D
A
E
K
F
A
E
E
D
K
K
L
K
E
R
I
D
T
R
N
E
L
E
S
Y
A
Y
S
L
K
N
Q
I
G
D
K
-
E
K
L
G
G
K
L
S
S
E
D
K
E
T
M
E
K
A
V
E
E
K
I
E
W
L
E
S
H
Q
D
A
D
I
E
D
F
K
A
K
K
K
E
L
E
E
I
V
Q
P
I
I
S
K
--------------------------------
40
HHSearch
72.17
62%
28
- C2 -
-
6ASY
5
BIP_HUMAN
B:
[2-606]
--
E
D
V
G
T
V
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
K
N
G
R
V
E
I
I
A
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
T
-
P
E
G
-
E
R
L
I
G
D
A
A
K
N
Q
L
T
S
N
P
E
N
T
V
F
D
A
K
R
L
I
G
R
T
W
N
D
P
S
V
Q
Q
D
I
K
F
L
P
F
K
V
V
E
K
K
-
T
K
P
Y
I
Q
V
-
D
I
G
G
G
Q
T
K
T
F
A
P
E
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
R
----
E
G
E
K
N
I
L
V
F
D
L
G
G
G
T
F
D
V
S
L
L
T
I
D
N
----
G
V
F
E
V
V
A
T
N
G
D
T
H
L
G
G
E
D
F
D
Q
R
V
M
E
H
F
I
K
L
Y
K
K
K
T
G
K
D
V
R
K
D
N
R
A
V
Q
K
L
R
R
E
V
E
K
A
K
R
A
L
S
S
Q
H
Q
A
R
I
E
I
E
S
F
Y
E
----
G
----
E
D
F
S
E
T
L
T
R
A
K
F
E
E
L
N
M
D
L
F
R
S
T
M
K
P
V
Q
K
V
L
E
D
S
D
L
K
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
E
F
F
N
G
K
E
P
S
R
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
G
D
---
Q
D
T
G
D
L
V
L
L
D
V
C
P
L
T
L
G
I
E
T
V
G
G
V
M
T
K
L
I
P
R
N
T
V
V
P
T
K
K
S
Q
I
F
S
V
----
G
G
T
V
T
I
K
V
Y
E
G
E
R
P
L
T
K
D
N
H
L
L
G
T
F
D
L
T
G
I
P
P
A
P
R
G
V
P
Q
I
E
V
T
F
E
I
D
V
N
G
I
L
R
V
T
A
E
D
K
G
T
G
N
K
N
K
I
T
I
T
N
D
Q
N
R
L
T
P
E
E
I
E
R
M
V
N
D
A
E
K
F
A
E
E
D
K
K
L
K
E
R
I
D
T
R
N
E
L
E
S
Y
A
Y
S
L
K
N
Q
I
-
G
D
K
E
K
L
G
G
K
L
S
S
E
D
K
E
T
M
E
K
A
V
E
E
K
I
E
W
L
E
S
H
Q
D
A
D
I
E
D
F
K
A
K
K
K
E
L
E
E
I
V
Q
P
I
I
S
K
--------------------------------
48
HHSearch
68.32
68%
21
- C2 -
-
6EOF
2
BIP_CRIGR
A:
[2-516]
------
T
V
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
K
N
G
R
V
E
I
I
A
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
T
-
P
-
E
G
E
R
L
I
G
D
A
A
K
N
Q
L
T
S
N
P
E
N
T
V
F
D
A
K
R
L
I
G
R
T
W
N
D
P
S
V
Q
Q
D
I
K
F
L
P
F
K
V
V
E
K
K
-
T
K
P
Y
I
Q
V
-
D
I
G
G
G
Q
T
K
T
F
A
P
E
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
R
----
E
G
E
K
N
I
L
V
F
D
L
G
G
G
A
F
D
V
S
L
L
T
I
D
N
----
G
V
F
E
V
V
A
T
N
G
D
T
H
L
G
G
E
D
F
D
Q
R
V
M
E
H
F
I
K
L
Y
K
K
K
T
G
K
D
V
R
K
D
N
R
A
V
Q
K
L
R
R
E
V
E
K
A
K
R
A
L
S
S
Q
H
Q
A
R
I
E
I
E
S
F
F
E
----
G
----
E
D
F
S
E
T
L
T
R
A
K
F
E
E
L
N
M
D
L
F
R
S
T
M
K
P
V
Q
K
V
L
E
D
S
D
L
K
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
E
F
F
N
G
K
E
P
S
R
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
G
D
---
Q
D
T
G
D
L
V
L
L
D
V
C
P
L
T
L
G
I
E
T
V
G
G
V
M
T
K
L
I
P
R
N
T
V
V
P
T
K
K
S
Q
I
F
S
T
A
S
D
N
Q
P
T
V
T
I
K
V
Y
E
G
E
R
P
L
T
K
D
N
H
L
L
G
T
F
D
L
T
G
I
P
P
A
P
R
G
V
P
Q
I
E
V
T
F
E
I
D
V
N
G
I
L
R
V
T
A
E
D
K
G
T
G
N
K
N
K
I
T
I
T
N
D
Q
N
R
L
T
P
E
E
I
E
R
M
V
N
---------------------------------------------------------------------------------------------------------------------------
47
HHSearch
68.30
55%
-28
- C2 -
-
2V7Y
1
DNAK_GEOKA
A:
[2-504]
-----
S
K
I
I
G
I
D
L
G
T
T
N
S
C
V
A
V
L
E
G
G
E
V
K
V
I
P
N
P
E
G
N
R
T
T
P
S
V
V
A
F
K
-
N
-
G
-
E
R
L
V
G
E
V
A
K
R
Q
A
I
T
N
P
-
N
T
I
I
S
I
K
R
H
M
G
T
D
Y
K
V
E
------------------------------
I
E
G
K
Q
Y
T
P
Q
E
I
S
A
I
I
L
Q
Y
L
K
S
Y
A
E
D
Y
L
G
E
P
V
T
R
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
E
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
D
K
E
-----
E
D
Q
T
I
L
V
Y
D
L
G
G
G
T
F
D
V
S
I
L
E
L
G
D
----
G
V
F
E
V
K
A
T
A
G
D
N
H
L
G
G
D
D
F
D
Q
V
I
I
D
Y
L
V
N
Q
F
K
Q
E
H
G
I
D
L
S
K
D
K
M
A
L
Q
R
L
K
D
A
A
E
K
A
K
K
E
L
S
G
V
T
Q
T
Q
I
S
L
P
F
I
S
A
NEN
G
P
----
L
H
L
E
M
T
L
T
R
A
K
F
E
E
L
S
A
H
L
V
E
R
T
M
G
P
V
R
Q
A
L
Q
D
A
G
L
T
P
A
D
I
D
K
V
I
L
V
G
G
S
T
R
I
P
A
V
Q
E
A
I
K
R
E
L
G
-
K
E
P
H
K
G
V
N
P
D
E
V
V
A
I
G
A
A
I
Q
G
G
V
I
A
G
E
-----
V
K
D
V
V
L
L
D
V
T
P
L
S
L
G
I
E
T
M
G
G
V
F
T
K
L
I
E
R
N
T
T
I
P
T
S
K
S
Q
V
F
T
T
A
A
D
N
Q
T
T
V
D
I
H
V
L
Q
G
E
R
P
M
A
A
D
N
K
S
L
G
R
F
Q
L
T
G
I
P
P
A
P
R
G
V
P
Q
I
E
V
T
F
D
I
D
A
N
G
I
V
H
V
R
A
K
D
L
G
T
N
K
E
Q
S
I
T
I
K
S
-
S
S
G
L
S
E
E
E
I
Q
R
M
I
K
E
A
E
E
N
A
E
A
D
R
K
R
K
E
A
A
E
L
---------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
68.12
67%
22
- C2 -
-
6EOE
1
BIP_CRIGR
A:
[3-521]
-------
V
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
K
N
G
R
V
E
I
I
A
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
T
P
E
-
G
-
E
R
L
I
G
D
A
A
K
N
Q
L
T
S
N
P
E
N
T
V
F
D
A
K
R
L
I
G
R
T
W
N
D
P
S
V
Q
Q
D
I
K
F
L
P
F
K
V
V
E
K
K
-
T
K
P
Y
I
Q
V
D
I
G
G
-
G
Q
T
K
T
F
A
P
E
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
R
----
E
G
E
K
N
I
L
V
F
D
L
G
G
G
A
F
D
V
S
L
L
T
I
D
N
----
G
V
F
E
V
V
A
T
N
G
D
T
H
L
G
G
E
D
F
D
Q
R
V
M
E
H
F
I
K
L
Y
K
K
K
T
G
K
D
V
R
K
D
N
R
A
V
Q
K
L
R
R
E
V
E
K
A
K
R
A
L
S
S
Q
H
Q
A
R
I
E
I
E
S
F
F
E
----
G
----
E
D
F
S
E
T
L
T
R
A
K
F
E
E
L
N
M
D
L
F
R
S
T
M
K
P
V
Q
K
V
L
E
D
S
D
L
K
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
E
F
F
N
G
K
E
P
S
R
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
G
D
---
Q
D
T
G
D
L
V
L
L
D
V
C
P
L
T
L
G
I
E
T
V
G
G
V
M
T
K
L
I
P
R
N
T
V
V
P
T
K
K
S
Q
I
F
S
T
A
S
D
N
Q
P
T
V
T
I
K
V
Y
E
G
E
R
P
L
T
K
D
N
H
L
L
G
T
F
D
L
T
G
I
P
P
A
P
R
G
V
P
Q
I
E
V
T
F
E
I
D
V
N
G
I
L
R
V
T
A
E
D
K
G
T
G
--
N
K
I
T
I
T
N
D
Q
N
R
L
T
P
E
E
I
E
R
M
V
N
D
A
E
K
F
----------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
67.83
67%
23
- C2 -
-
6EOF
2
BIP_CRIGR
A:
[3-521]
-------
V
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
K
N
G
R
V
E
I
I
A
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
T
P
E
-
G
-
E
R
L
I
G
D
A
A
K
N
Q
L
T
S
N
P
E
N
T
V
F
D
A
K
R
L
I
G
R
T
W
N
D
P
S
V
Q
Q
D
I
K
F
L
P
F
K
V
V
E
K
K
-
T
K
P
Y
I
Q
V
D
I
G
G
-
G
Q
T
K
T
F
A
P
E
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
K
R
----
E
G
E
K
N
I
L
V
F
D
L
G
G
G
A
F
D
V
S
L
L
T
I
D
N
----
G
V
F
E
V
V
A
T
N
G
D
T
H
L
G
G
E
D
F
D
Q
R
V
M
E
H
F
I
K
L
Y
K
K
K
T
G
K
D
V
R
K
D
N
R
A
V
Q
K
L
R
R
E
V
E
K
A
K
R
A
L
S
S
Q
H
Q
A
R
I
E
I
E
S
F
F
E
----
G
----
E
D
F
S
E
T
L
T
R
A
K
F
E
E
L
N
M
D
L
F
R
S
T
M
K
P
V
Q
K
V
L
E
D
S
D
L
K
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
E
F
F
N
G
K
E
P
S
R
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
G
D
---
Q
D
T
G
D
L
V
L
L
D
V
C
P
L
T
L
G
I
E
T
V
G
G
V
M
T
K
L
I
P
R
N
T
V
V
P
T
K
K
S
Q
I
F
S
T
A
S
D
N
Q
P
T
V
T
I
K
V
Y
E
G
E
R
P
L
T
K
D
N
H
L
L
G
T
F
D
L
T
G
I
P
P
A
P
R
G
V
P
Q
I
E
V
T
F
E
I
D
V
N
G
I
L
R
V
T
A
E
D
K
G
T
G
N
K
N
K
I
T
I
T
N
D
Q
N
R
L
T
P
E
E
I
E
R
M
V
N
D
A
E
K
F
----------------------------------------------------------------------------------------------------------------------
42
HHSearch
67.13
49%
32
- C2 -
-
4JNE
4
DNAK_ECOLI
B:
[2-600]
-----
G
K
I
I
G
I
D
L
G
T
T
N
S
C
V
A
I
M
D
G
T
T
P
R
V
L
E
N
A
E
G
D
R
T
T
P
S
I
I
A
Y
T
-
Q
D
G
-
E
T
L
V
G
Q
P
A
K
R
Q
A
V
T
N
P
Q
N
T
L
F
A
I
K
R
L
I
G
R
R
F
Q
D
E
E
V
Q
R
D
V
S
I
M
P
F
K
I
I
A
A
D
N
G
D
A
W
V
E
------
V
K
G
Q
K
M
A
P
P
Q
I
S
A
E
V
L
K
K
M
K
K
T
A
E
D
Y
L
G
E
P
V
T
E
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
K
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
D
K
G
----
T
G
N
R
T
I
A
V
Y
D
L
G
G
G
A
F
D
I
S
I
I
E
I
D
E
VDGE
K
T
F
E
V
L
A
T
N
G
D
T
H
L
G
G
E
D
F
D
S
R
L
I
N
Y
L
V
E
E
F
K
K
D
Q
G
I
D
L
R
N
D
P
L
A
M
Q
R
L
K
E
A
A
E
K
A
K
I
E
L
S
S
A
Q
Q
T
D
V
N
L
P
Y
I
T
A
----
D
ATGP
K
H
M
N
I
K
V
T
R
A
K
L
E
S
L
V
E
D
L
V
N
R
S
I
E
P
L
K
V
A
L
Q
D
A
G
L
S
V
S
D
I
D
D
V
I
L
V
G
G
Q
T
R
M
P
M
V
Q
K
K
V
A
E
F
F
G
-
K
E
P
R
K
D
V
N
P
D
E
A
V
A
I
G
A
A
V
Q
G
G
V
L
T
G
D
-----
V
K
D
V
L
L
L
D
V
T
P
L
S
L
G
I
E
T
M
G
G
V
M
T
T
L
I
A
K
N
T
T
I
P
T
K
H
S
Q
V
F
S
M
----
G
G
A
V
T
I
H
V
L
Q
G
E
R
K
R
A
A
D
N
K
S
L
G
Q
F
N
L
D
G
I
N
P
A
P
R
G
M
P
Q
I
E
V
T
F
D
I
D
A
D
G
I
L
H
V
S
A
K
D
K
N
S
G
K
E
Q
K
I
T
I
K
A
S
-
S
G
L
N
E
D
E
I
Q
K
M
V
R
D
A
E
A
N
A
E
A
D
R
K
F
E
E
L
V
Q
T
R
N
Q
G
D
H
L
L
H
S
T
R
K
Q
V
-
E
E
---
A
G
D
K
L
P
A
D
D
K
T
A
I
E
S
A
L
T
A
L
E
T
A
L
K
G
E
D
K
---
A
A
I
E
A
K
M
Q
E
L
A
Q
V
S
Q
K
L
M
E
I
A
Q
Q
-----------------------------