@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : WWP2_HUMAN: (2018-10-04 )
MASASSSRAGVALPFEKSQLTLKVVSAKPKVHNRQPRINSYVEVAVDGLPSETKKTGKRIGSSELLWNEIIILNVTAQSHLDLKVWSCHTLRNELLGTASVNLSNVLKNNGGKMENMQLTLNLQTENKGSVVSGGELTIFLDGPTVDLGNVPNGSALTDGSQLPSRDSSGTAVAPENRHQPPSTNCFGGRSRTHRHSGASARTTPATGEQSPGARSRHRQPVKNSGHSGLANGTVNDEPTTATDPEEPSVVGVTSPPAAPLSVTPNPNTTSLPAPATPAEGEEPSTSGTQQLPAAAQAPDALPAGWEQRELPNGRVYYVDHNTKTTTWERPLPPGWEKRTDPRGRFYYVDHNTRTTTWQRPTAEYVRNYEQWQSQRNQLQGAMQHFSQRFLYQSSSASTDHDPLGPLPPGWEKRQDNGRVYYVNHNTRTTQWEDPRTQGMIQEPALPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFESGTKQGSPGAYDRSFRWKYHQFRFLCHSNALPSHVKISVSRQTLFEDSFQQIMNMKPYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKFIDTGFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLEECGLELYFIQDMEILGKVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEIDMSDWQKSTIYRHYTKNSKQIQWFWQVVKEMDNEKRIRLLQFVTGTCRLPVGGFAELIGSNGPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSYEQLREKLLYAIEETEGFGQE
Atome Classification :
(21 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330-........340.......350.......360.......370.......380.......390.......400.......410....-...420.......430.......440.......450.......460.......470.......----------------------------480.......-490.......500..-...-.---.510.......520.......530....-...-540.......550.......560.......570.......580.......590.....-..600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.....-.-.770.......780.......790.......800.......810.......820.....-..830........840.......850.......860.-......870
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MASASSSRA
G
V
ALPFEKS
Q
L
T
L
K
V
VSAKPKVHNRQPR
I
N
S
Y
V
E
V
AVDGLP
S
E
T
K
K
T
G
K
RIGSSE
L
L
W
N
E
I
I
I
L
N
V
TAQSHL
D
L
K
V
W
S
C
H
T
L
R
N
ELLGTASV
N
L
S
N
V
L
K
NNGGK
M
E
N
M
Q
L
T
L
N
L
QTENKGSVVSG
G
E
L
T
I
F
LDGPTVDLGNVPNGSALTDGSQLPSRDSSGTAVAPENRHQPPSTNCFGGRSRTHRHSGASARTTPATGEQSPGARSRHRQPVKNSGHSGLANGTVNDEPTTATDPEEP
S
V
V
GVTSPPAA
P
L
S
VTPNPNTTSLPAPATPAEGEEPSTSGTQQLPAAAQAPDALPAGWEQRELPNG
R
V
Y
Y
V
DHNTKTTTWERP--LPPGWEKRTDPRG
R
F
Y
Y
V
DHNTRTTTWQR
P
T
A
E
Y
V
R
N
Y
E
Q
W
Q
S
Q
R
N
Q
L
Q
G
A
M
Q
H
F
S
Q
R
F
L
YQSSSASTDHDPLGPLPPGWEKRQD-N
G
R
V
Y
Y
V
NHNTRTTQWEDPRTQGMIQEPALPPGWE
M
K
YTSEG
V
R
Y
F
V
DHNTRTTTFKDPRPGF----------------------------ESGTKQGSPG-AYDR
S
F
R
W
K
Y
H
Q
F
R
F
-
L
CH-S---NALP
S
H
V
K
I
S
V
S
R
Q
T
L
F
E
D
S
F
Q
Q
I
MNMK-
P
Y
D
-
L
R
R
R
L
Y
I
I
M
RGEEGLDY
G
G
I
A
R
E
W
F
F
L
L
S
H
E
VL
N
P
M
Y
C
L
F
E
YAGKN
N
Y
C
L
Q
INPASSI-N
P
D
H
L
T
Y
F
R
F
I
G
R
F
I
A
M
A
L
YHGKFIDTGFT
L
P
F
Y
K
R
M
LNKRPT
L
K
D
L
E
SI
D
P
E
F
Y
N
S
I
V
W
I
KEN
N
L
E
E
CG
L
E
L
Y
F
IQD
M
E
I
L
G
K
V
T
T
H
E
L
K
EGG
E
S
I
R
VTEENKE
E
Y
I
M
L
L
TDWRFTRG
V
E
E
Q
T
K
A
F
L
D
G
FNEV
A
P
L
E
W
L
R
Y
F
D
E
K
E
L
E
L
M
L
CG
M
Q
EI
D
M
S
D
W
Q
K
S
T
I
Y
R
-H-YTKNS
K
Q
I
Q
W
F
W
Q
V
V
K
EMD
N
E
K
R
I
R
L
L
Q
F
VTGTCRLPV
G
G
F
A
E
L
IGSNGP
Q
K
F
C
I
D
KVG-KETW-LPRSH
T
C
F
NRLDLPP
Y
K
S
Y
E
Q
L
R
E
K
L
L
Y
A
I
E
E-TEGFGQE
24
HHSearch
88.95
83%
-115
- C2 -
-
1ND7
-
WWP1_HUMAN
A:
[545-917]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
G
F
R
W
K
L
A
H
F
R
Y
-
L
C
Q
-
S
---
N
A
L
P
S
H
V
K
I
N
V
S
R
Q
T
L
F
E
D
S
F
Q
Q
I
M
A
L
K
-
P
Y
D
-
L
R
R
R
L
Y
V
I
F
R
G
E
E
G
L
D
Y
G
G
L
A
R
E
W
F
F
L
L
S
H
E
V
L
N
P
M
Y
C
L
F
E
Y
A
G
K
N
N
Y
C
L
Q
I
N
P
A
S
T
I
-
N
P
D
H
L
S
Y
F
C
F
I
G
R
F
I
A
M
A
L
F
H
G
K
F
I
D
T
G
F
S
L
P
F
Y
K
R
M
L
S
K
K
L
T
I
K
D
L
E
S
I
D
T
E
F
Y
N
S
L
I
W
I
R
D
N
N
I
E
E
C
G
L
E
M
Y
F
S
V
D
M
E
I
L
G
K
V
T
S
H
D
L
K
L
G
G
S
N
I
L
V
T
E
E
N
K
D
E
Y
I
G
L
M
T
E
W
R
F
S
R
G
V
Q
E
Q
T
K
A
F
L
D
G
F
N
E
V
V
P
L
Q
W
L
Q
Y
F
D
E
K
E
L
E
V
M
L
C
G
M
Q
E
V
D
L
A
D
W
Q
R
N
T
V
Y
R
-
H
-
Y
T
R
N
S
K
Q
I
I
W
F
W
Q
F
V
K
E
T
D
N
E
V
R
M
R
L
L
Q
F
V
T
G
T
C
R
L
P
L
G
G
F
A
E
L
M
G
S
N
G
P
Q
K
F
C
I
E
K
V
G
-
K
D
T
W
-
L
P
R
S
H
T
C
F
N
R
L
D
L
P
P
Y
K
S
Y
E
Q
L
K
E
K
L
L
F
A
I
E
E
-
T
E
-----
8
PsiBlast_PDB
88.78
83%
-117
- C2 -
-
1ND7
-
WWP1_HUMAN
A:
[547-917]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
R
W
K
L
A
H
F
R
Y
-
L
C
Q
-
S
---
N
A
L
P
S
H
V
K
I
N
V
S
R
Q
T
L
F
E
D
S
F
Q
Q
I
M
A
L
K
-
P
Y
D
-
L
R
R
R
L
Y
V
I
F
R
G
E
E
G
L
D
Y
G
G
L
A
R
E
W
F
F
L
L
S
H
E
V
L
N
P
M
Y
C
L
F
E
Y
A
G
K
N
N
Y
C
L
Q
I
N
P
A
S
T
I
-
N
P
D
H
L
S
Y
F
C
F
I
G
R
F
I
A
M
A
L
F
H
G
K
F
I
D
T
G
F
S
L
P
F
Y
K
R
M
L
S
K
K
L
T
I
K
D
L
E
S
I
D
T
E
F
Y
N
S
L
I
W
I
R
D
N
N
I
E
E
C
G
L
E
M
Y
F
S
V
D
M
E
I
L
G
K
V
T
S
H
D
L
K
L
G
G
S
N
I
L
V
T
E
E
N
K
D
E
Y
I
G
L
M
T
E
W
R
F
S
R
G
V
Q
E
Q
T
K
A
F
L
D
G
F
N
E
V
V
P
L
Q
W
L
Q
Y
F
D
E
K
E
L
E
V
M
L
C
G
M
Q
E
V
D
L
A
D
W
Q
R
N
T
V
Y
R
-
H
-
Y
T
R
N
S
K
Q
I
I
W
F
W
Q
F
V
K
E
T
D
N
E
V
R
M
R
L
L
Q
F
V
T
G
T
C
R
L
P
L
G
G
F
A
E
L
M
G
S
N
G
P
Q
K
F
C
I
E
K
V
G
-
K
D
T
W
-
L
P
R
S
H
T
C
F
N
R
L
D
L
P
P
Y
K
S
Y
E
Q
L
K
E
K
L
L
F
A
I
E
E
-
T
E
-----
7
PsiBlast_PDB
86.56
81%
-111
- C2 -
-
5HPT
-
WWP1_HUMAN
A:
[545-917]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
G
F
R
W
K
L
A
H
F
R
Y
-
L
C
Q
-
S
---
N
A
L
P
S
H
V
K
I
N
V
S
R
Q
T
L
F
E
D
S
F
Q
Q
I
M
A
L
K
-
P
Y
D
-
L
R
R
R
L
Y
V
I
F
R
G
E
E
G
L
D
Y
G
G
L
A
R
E
W
F
F
L
L
S
H
E
V
L
N
P
M
Y
C
L
F
E
Y
A
G
K
N
N
Y
C
L
Q
I
N
P
A
S
T
I
-
N
P
D
H
L
S
Y
F
C
F
I
G
R
F
I
A
M
A
L
F
H
G
K
F
I
D
T
G
F
S
L
P
F
Y
K
R
M
L
S
K
K
L
T
I
K
D
L
E
S
I
D
T
E
F
Y
N
S
L
I
W
I
R
D
N
N
I
E
E
C
G
L
E
M
Y
F
S
V
D
M
E
I
L
G
K
V
T
S
H
D
L
K
L
G
G
S
N
I
L
V
T
E
E
N
K
D
E
Y
I
G
L
M
T
E
W
R
F
S
R
G
V
Q
E
Q
T
K
A
F
L
D
G
F
N
E
V
V
P
L
Q
W
L
Q
Y
F
D
E
K
E
L
E
V
M
L
C
G
M
Q
E
V
D
L
A
D
W
Q
R
N
T
V
Y
R
-
H
-
Y
T
R
N
S
K
Q
I
I
W
F
W
Q
F
V
K
E
T
D
N
E
V
R
M
R
L
L
Q
F
V
T
G
T
C
R
L
P
L
G
G
F
A
E
L
M
G
S
N
G
P
Q
K
F
C
I
E
K
V
G
-
K
D
T
W
-
L
P
R
S
H
T
C
F
N
R
L
D
L
P
P
Y
K
S
Y
E
Q
L
K
E
K
L
L
F
A
I
E
E
-
T
E
-----
2
PsiBlast_PDB
83.89
89%
27
- C2 -
-
5TJ7
-
WWP2_HUMAN
A:
[3-447]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
W
E
K
R
T
D
P
R
G
R
F
Y
Y
V
D
H
N
T
R
T
T
T
W
Q
R
P
T
A
E
Y
V
R
N
Y
E
Q
W
Q
S
Q
R
N
Q
LQGA
M
Q
H
F
S
Q
R
F
L
Y
Q
S
S
----------
Y
D
R
S
F
R
W
K
Y
H
Q
F
R
F
-
L
C
H
-
S
---
N
A
L
P
S
H
V
K
I
S
V
S
R
Q
T
L
F
E
D
S
F
Q
Q
I
M
N
M
K
-
P
Y
D
-
L
R
R
R
L
Y
I
I
M
R
G
E
E
G
L
D
Y
G
G
I
A
R
E
W
F
F
L
L
S
H
E
V
L
N
P
M
Y
C
L
F
E
Y
A
G
K
N
N
Y
C
L
Q
I
N
P
A
S
S
I
-
N
P
D
H
L
T
Y
F
R
F
I
G
R
F
I
A
M
A
L
Y
H
G
K
F
I
D
T
G
F
T
L
P
F
Y
K
R
M
L
N
K
R
P
T
L
K
D
L
E
S
I
D
P
E
F
Y
N
S
I
V
W
I
K
E
N
N
L
E
E
C
G
L
E
L
Y
F
I
Q
D
M
E
I
L
G
K
V
T
T
H
E
L
K
E
G
G
E
S
I
R
V
T
E
E
N
K
E
E
Y
I
M
L
L
T
D
W
R
F
T
R
G
V
E
E
Q
T
K
A
F
L
D
G
F
N
E
V
A
P
L
E
W
L
R
Y
F
D
E
K
E
L
E
L
M
L
C
G
M
Q
E
I
D
M
S
D
W
Q
K
S
T
I
Y
R
-
H
-
Y
T
K
N
S
K
Q
I
Q
W
F
W
Q
V
V
K
E
M
D
N
E
K
R
I
R
L
L
Q
F
V
T
G
T
C
R
L
P
V
G
G
F
A
E
L
I
G
S
N
G
P
Q
K
F
C
I
D
K
V
G
-
K
E
T
W
-
L
P
R
S
H
T
C
F
N
R
L
D
L
P
P
Y
K
S
Y
E
Q
L
R
E
K
L
L
Y
A
I
E
E
-
T
E
-----
21
HHSearch
83.63
90%
-97
- C2 -
-
5TJ8
-
WWP2_HUMAN
A:
[25-446]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
W
Q
R
P
T
A
E
Y
----
V
R
N
Y
E
Q
W
Q
S
Q
R
N
Q
L
Q
--
G
A
M
Q
H
F
S
Q
R
F
L
Y
Q
--
S
S
------------------------------------
G
S
P
G
-
A
Y
D
R
S
F
R
W
K
Y
H
Q
F
R
F
-
L
C
H
-
S
---
N
A
L
P
S
H
V
K
I
S
V
S
R
Q
T
L
F
E
D
S
F
Q
Q
I
M
N
M
K
-
P
Y
D
-
L
R
R
R
L
Y
I
I
M
R
G
E
E
-
L
D
Y
G
G
I
A
R
E
W
F
F
L
L
S
H
E
V
L
N
P
M
Y
C
L
F
E
Y
A
G
K
N
N
Y
C
L
Q
I
N
P
A
S
S
I
-
N
P
D
H
L
T
Y
F
R
F
I
G
R
F
I
A
M
A
L
Y
H
G
K
F
I
D
T
G
F
T
L
P
F
Y
K
R
M
L
N
K
R
P
T
L
K
D
L
E
S
I
D
P
E
F
Y
N
S
I
V
W
I
------
E
C
G
L
E
L
Y
F
I
Q
D
M
E
---
K
V
T
T
H
E
L
K
E
G
G
E
S
I
R
V
T
E
E
N
K
E
E
Y
I
M
L
L
T
D
W
R
F
T
R
G
V
E
E
Q
T
K
A
F
L
D
G
F
N
E
V
A
P
L
E
W
L
R
Y
F
D
E
K
E
L
E
L
M
L
C
G
M
Q
E
I
D
M
S
D
W
Q
K
S
T
I
Y
R
-
H
-
Y
T
K
N
S
K
Q
I
Q
W
F
W
Q
V
V
K
E
M
D
N
E
K
R
I
R
L
L
Q
F
V
T
G
T
C
R
L
P
V
G
G
F
A
E
L
I
G
S
N
G
P
Q
K
F
C
I
D
K
V
G
-
K
E
T
W
-
L
P
R
S
H
T
C
F
N
R
L
D
L
P
P
Y
K
S
Y
E
Q
L
R
E
K
L
L
Y
A
I
E
E
-
T
------
22
HHSearch
81.50
90%
7
- C2 -
-
5TJ7
-
WWP2_HUMAN
D:
[3-447]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
W
E
K
R
T
D
P
R
G
R
F
Y
Y
V
D
H
N
T
R
T
T
T
W
Q
R
P
T
A
E
Y
----
V
R
N
Y
E
Q
W
Q
S
Q
R
N
Q
L
Q
--
G
A
M
Q
H
F
S
Q
R
F
L
Y
Q
--
S
S
S
A
--------------------------------
S
Q
G
S
P
G
-
A
Y
D
R
S
F
R
W
K
Y
H
Q
F
R
F
-
L
C
H
-
S
---
N
A
L
P
S
H
V
K
I
S
V
S
R
Q
T
L
F
E
D
S
F
Q
Q
I
M
N
M
K
-
P
Y
D
-
L
R
R
R
L
Y
I
I
M
R
G
E
E
G
L
D
Y
G
G
I
A
R
E
W
F
F
L
L
S
H
E
V
L
N
P
M
Y
C
L
F
E
Y
A
G
K
N
N
Y
C
L
Q
I
N
P
A
S
S
I
-
N
P
D
H
L
T
Y
F
R
F
I
G
R
F
I
A
M
A
L
Y
H
G
K
F
I
D
T
G
F
T
L
P
F
Y
K
R
M
L
N
K
R
P
T
L
K
D
L
E
S
I
D
P
E
F
Y
N
S
I
V
W
I
K
E
N
N
L
E
E
C
G
L
E
L
Y
F
I
Q
D
M
E
I
L
G
K
V
T
T
H
E
L
K
E
G
G
E
S
I
R
V
T
E
E
N
K
E
E
Y
I
M
L
L
T
D
W
R
F
T
R
G
V
E
E
Q
T
K
A
F
L
D
G
F
N
E
V
A
P
L
E
W
L
R
Y
F
D
E
K
E
L
E
L
M
L
C
G
M
Q
E
I
D
M
S
D
W
Q
K
S
T
I
Y
R
-
H
-
Y
T
K
N
S
K
Q
I
Q
W
F
W
Q
V
V
K
E
M
D
N
E
K
R
I
R
L
L
Q
F
V
T
G
T
C
R
L
P
V
G
G
F
A
E
L
I
G
S
N
G
P
Q
K
F
C
I
D
K
V
G
-
K
E
T
W
-
L
P
R
S
H
T
C
F
N
R
L
D
L
P
P
Y
K
S
Y
E
Q
L
R
E
K
L
L
Y
A
I
E
E
-
T
E
-----
3
PsiBlast_PDB
81.27
89%
-122
- C2 -
-
5TJQ
-
WWP2_HUMAN
A:
[74-446]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
S
F
R
W
K
Y
H
Q
F
R
F
-
L
C
H
-
S
---
N
A
L
P
S
H
V
K
I
S
V
S
R
Q
T
L
F
E
D
S
F
Q
Q
I
M
N
M
K
-
P
Y
D
-
L
R
R
R
L
Y
I
I
M
R
G
E
E
----
G
G
I
A
R
E
W
F
F
L
L
S
H
E
V
L
N
P
M
Y
C
L
F
E
Y
A
G
K
N
N
Y
C
L
Q
I
N
P
A
S
S
I
-
N
P
D
H
L
T
Y
F
R
F
I
G
R
F
I
A
M
A
L
Y
H
G
K
F
I
D
T
G
F
T
L
P
F
Y
K
R
M
L
N
K
R
P
T
L
K
D
L
E
S
I
D
P
E
F
Y
N
S
I
V
W
I
K
E
N
N
L
E
E
C
G
L
E
L
Y
F
I
Q
D
M
E
I
L
G
K
--------
G
G
E
S
I
R
V
T
E
E
N
K
E
E
Y
I
M
L
L
T
D
W
R
F
T
R
G
V
E
E
Q
T
K
A
F
L
D
G
F
N
E
V
A
P
L
E
W
L
R
Y
F
D
E
K
E
L
E
L
M
L
C
G
M
Q
E
I
D
M
S
D
W
Q
K
S
T
I
Y
R
-
H
-
Y
T
K
N
S
K
Q
I
Q
W
F
W
Q
V
V
K
E
M
D
N
E
K
R
I
R
L
L
Q
F
V
T
G
T
C
R
L
P
V
G
G
F
A
E
L
I
G
S
N
G
P
Q
K
F
C
I
D
K
V
G
-
K
E
T
W
-
L
P
R
S
H
T
C
F
N
R
L
D
L
P
P
Y
K
S
Y
E
Q
L
R
E
K
L
L
Y
A
I
E
E
-
T
------
26
HHSearch
79.53
82%
-101
- C2 -
-
5HPS
-
WWP1_HUMAN
A:
[541-917]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
-
A
Y
E
R
G
F
R
W
K
L
A
H
F
R
Y
-
L
C
Q
-
S
---
N
A
L
P
S
H
V
K
I
N
V
S
R
Q
T
L
F
E
D
S
F
Q
Q
I
M
A
L
K
-
P
Y
D
-
L
R
R
R
L
Y
V
I
F
R
G
E
E
---
Y
G
G
L
A
R
E
W
F
F
L
L
S
H
E
V
L
N
P
M
Y
C
L
F
E
Y
A
G
K
N
N
Y
C
L
Q
I
N
P
A
S
T
I
-
N
P
D
H
L
S
Y
F
C
F
I
G
R
F
I
A
M
A
L
F
H
G
K
F
I
D
T
G
F
S
L
P
F
Y
K
R
M
L
S
K
K
L
T
I
K
D
L
E
S
I
D
T
E
F
Y
N
S
L
I
W
I
R
D
N
N
I
E
E
C
G
L
E
M
Y
F
S
V
D
M
E
I
L
G
K
V
T
S
H
D
L
K
L
G
G
S
N
I
L
V
T
E
E
N
K
D
E
Y
I
G
L
M
T
E
W
R
F
S
R
G
V
Q
E
Q
T
K
A
F
L
D
G
F
N
E
V
V
P
L
Q
W
L
Q
Y
F
D
E
K
E
L
E
V
M
L
C
G
M
Q
E
V
D
L
A
D
W
Q
R
N
T
V
Y
R
-
H
-
Y
T
R
N
S
K
Q
I
I
W
F
W
Q
F
V
K
E
T
D
N
E
V
R
M
R
L
L
Q
F
V
T
G
T
C
R
L
P
L
G
G
F
A
E
L
M
G
S
N
G
P
Q
K
F
C
I
E
K
V
G
-
K
D
T
W
-
L
P
R
S
H
T
C
F
N
R
L
D
L
P
P
Y
K
S
Y
E
Q
L
K
E
K
L
L
F
A
I
E
E
-
T
E
-----
5
PsiBlast_PDB
77.79
100%
-108
- C- -
-
4Y07
-
WWP2_HUMAN
A:
[492-865]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
S
F
R
W
K
Y
H
Q
F
R
F
-
L
C
H
-
S
---
N
A
L
P
S
H
V
K
I
S
V
S
R
Q
T
L
F
E
D
S
F
Q
Q
I
M
N
M
K
-
P
Y
D
-
L
R
R
R
L
Y
I
I
M
R
G
E
E
G
L
D
Y
G
G
I
A
R
E
W
F
F
L
L
S
H
E
V
L
N
P
M
Y
C
L
F
E
Y
A
G
K
N
N
Y
C
L
Q
I
N
P
A
S
S
I
-
N
P
D
H
L
T
Y
F
R
F
I
G
R
F
I
A
M
A
L
Y
H
G
K
F
I
D
T
G
F
T
L
P
F
Y
K
R
M
L
N
K
R
P
T
L
K
D
L
E
S
I
D
P
E
F
Y
N
S
I
V
W
I
K
E
N
-----------------------------------------
E
Y
I
M
L
L
T
D
W
R
F
T
R
G
V
E
E
Q
T
K
A
F
L
D
G
F
N
E
V
A
P
L
E
W
L
R
Y
F
D
E
K
E
L
E
L
M
L
C
G
M
Q
E
I
D
M
S
D
W
Q
K
S
T
I
Y
R
-
H
-
Y
T
K
N
S
K
Q
I
Q
W
F
W
Q
V
V
K
E
M
D
N
E
K
R
I
R
L
L
Q
F
V
T
G
T
C
R
L
P
V
G
G
F
A
E
L
I
G
S
N
G
P
Q
K
F
C
I
D
K
V
G
-
K
E
T
W
-
L
P
R
S
H
T
C
F
N
R
L
D
L
P
P
Y
K
S
Y
E
Q
L
R
E
K
L
L
Y
A
I
E
E
-
T
E
-----
9
PsiBlast_PDB
76.11
74%
-134
- C2 -
-
3TUG
-
A:
[20-392]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
R
D
F
K
A
K
V
Q
Y
F
R
F
-
W
C
Q
-
Q
---
L
A
M
P
Q
H
I
K
I
T
V
T
R
K
T
L
F
E
D
S
F
Q
Q
I
M
S
F
S
-
P
Q
D
-
L
R
R
R
L
W
V
I
F
P
G
E
E
G
L
D
Y
G
G
V
A
R
E
W
F
F
L
L
S
H
E
V
S
N
P
M
Y
C
L
F
E
Y
A
----
Y
C
L
Q
I
N
P
A
S
Y
I
-
N
P
D
H
L
K
Y
F
R
F
I
G
R
F
I
A
M
A
L
F
H
G
K
F
I
D
T
G
F
S
L
P
F
Y
K
R
I
L
N
K
P
V
G
L
K
D
L
E
S
I
D
P
E
F
Y
N
S
L
I
W
V
K
E
N
N
--------
Y
F
S
---------------------------
K
E
E
Y
I
R
M
V
A
E
W
R
L
S
R
G
V
E
E
Q
T
Q
A
F
F
E
G
F
N
E
I
L
P
Q
Q
Y
L
Q
Y
F
D
A
K
E
L
E
V
L
L
C
G
M
Q
E
I
D
L
N
D
W
Q
R
H
A
I
Y
R
-
R
-
Y
A
R
T
S
K
Q
I
M
W
F
W
Q
F
V
K
E
I
D
N
E
K
R
M
R
L
L
Q
F
V
T
G
T
C
R
L
P
V
G
G
F
A
D
L
M
G
S
N
G
P
Q
K
F
C
I
E
K
V
G
-
K
E
N
W
-
L
P
R
S
H
T
C
F
N
R
L
D
L
P
P
Y
K
S
Y
E
Q
L
K
E
K
L
L
F
A
I
E
E
-
T
------
4
PsiBlast_PDB
75.32
89%
21
- C2 -
-
5TJ8
-
WWP2_HUMAN
A:
[25-446]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
W
Q
R
P
T
A
E
Y
V
R
N
Y
E
Q
W
Q
S
Q
R
N
Q
L
Q
G
A
M
Q
H
F
S
Q
RFLYQ
S
S
----
G
S
P
G
-
A
Y
D
R
S
F
R
W
K
Y
H
Q
F
R
F
-
L
C
H
-
S
---
N
A
L
P
S
H
V
K
I
S
V
S
R
Q
T
L
F
E
D
S
F
Q
Q
I
M
N
M
K
-
P
Y
D
-
L
R
R
R
L
Y
I
I
M
R
G
E
E
-
L
D
Y
G
G
I
A
R
E
W
F
F
L
L
S
H
E
V
L
N
P
M
Y
C
L
F
E
Y
A
G
K
N
N
Y
C
L
Q
I
N
P
A
S
S
I
-
N
P
D
H
L
T
Y
F
R
F
I
G
R
F
I
A
M
A
L
Y
H
G
K
F
I
D
T
G
F
T
L
P
F
Y
K
R
M
L
N
K
R
P
T
L
K
D
L
E
S
I
D
P
E
F
Y
N
S
I
V
W
I
------
E
C
G
L
E
L
Y
F
I
Q
D
M
E
---
K
V
T
T
H
E
L
K
E
G
G
E
S
I
R
V
T
E
E
N
K
E
E
Y
I
M
L
L
T
D
W
R
F
T
R
G
V
E
E
Q
T
K
A
F
L
D
G
F
N
E
V
A
P
L
E
W
L
R
Y
F
D
E
K
E
L
E
L
M
L
C
G
M
Q
E
I
D
M
S
D
W
Q
K
S
T
I
Y
R
-
H
-
Y
T
K
N
S
K
Q
I
Q
W
F
W
Q
V
V
K
E
M
D
N
E
K
R
I
R
L
L
Q
F
V
T
G
T
C
R
L
P
V
G
G
F
A
E
L
I
G
S
N
G
P
Q
K
F
C
I
D
K
V
G
-
K
E
T
W
-
L
P
R
S
H
T
C
F
N
R
L
D
L
P
P
Y
K
S
Y
E
Q
L
R
E
K
L
L
Y
A
I
E
E
-
T
------
12
PsiBlast_PDB
74.15
51%
-95
- C2 -
-
4LCD
-
RSP5_YEAST (first)
A:
[12-429]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
S
G
W
E
M
R
L
T
N
T
A
R
V
Y
F
V
D
H
N
T
K
T
T
T
W
D
D
P
R
--
L
----------------------------
P
S
S
L
D
Q
N
V
P
--
Q
Y
K
R
D
F
R
R
K
V
I
Y
F
R
S
-
Q
P
A
-
L
---
R
I
L
P
G
Q
L
H
I
K
V
R
R
K
N
I
F
E
D
A
Y
Q
E
I
M
R
Q
T
-
P
E
D
-
L
K
K
R
L
M
I
K
F
D
G
-----
Y
G
G
V
S
R
E
F
F
F
L
L
S
H
E
M
F
N
P
F
Y
G
L
F
E
Y
S
A
Y
D
N
Y
T
I
Q
I
N
P
N
S
G
I
-
N
P
E
H
L
N
Y
F
K
F
I
G
R
V
V
G
L
G
V
F
H
R
R
F
L
D
A
F
F
V
G
A
L
Y
K
M
M
L
R
K
K
V
V
L
Q
D
M
E
G
V
D
A
E
V
Y
N
S
L
N
W
M
L
E
N
S
I
D
G
V
-
L
D
L
T
F
S
A
D
D
E
R
F
G
E
V
V
T
V
D
L
K
P
D
G
R
N
I
E
V
T
D
G
N
K
K
E
Y
V
E
L
Y
T
Q
W
R
I
V
D
R
V
Q
E
Q
F
K
A
F
M
D
G
F
N
E
L
I
P
E
D
L
V
T
V
F
D
E
R
E
L
E
L
L
I
G
G
I
A
E
I
D
I
E
D
W
K
K
H
T
D
Y
R
-
G
-
Y
Q
E
S
D
E
V
I
Q
W
F
W
K
A
V
S
E
W
D
N
E
Q
R
A
R
L
L
Q
F
T
T
G
T
S
R
I
P
V
N
G
F
K
D
L
Q
G
S
D
G
P
R
R
F
T
I
E
K
A
G
-
E
V
Q
Q
-
L
P
K
S
H
T
C
F
N
R
V
D
L
P
Q
Y
V
D
Y
D
S
M
K
Q
K
L
T
L
A
V
E
E
-
T
I
G
F
---
42
Fugue
73.40
38%
-75
* C2 *
-
5LP8
-
HUWE1_HUMAN
A:
[12-448]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
D
I
P
T
F
Q
G
-------
A
D
T
Q
K
F
L
R
F
A
E
T
H
R
T
V
L
N
Q
I
L
R
Q
S
T
T
H
L
A
D
G
P
F
----------------------------
A
V
L
V
D
Y
I
R
V
L
-
D
F
D
V
K
R
K
Y
F
R
Q
E
L
E
R
-
L
-
D
-
E
---
G
L
R
K
E
D
M
A
V
H
V
R
R
D
H
V
F
E
D
S
Y
R
E
L
H
R
K
S
-
P
E
E
-
M
K
N
R
L
Y
I
V
F
E
G
E
E
G
Q
D
A
G
G
L
L
R
E
W
Y
M
I
I
S
R
E
M
F
N
P
M
Y
A
L
F
R
T
S
P
G
D
R
V
T
Y
T
I
N
P
S
S
H
C
-
N
P
N
H
L
S
Y
F
K
F
V
G
R
I
V
A
K
A
V
Y
D
N
R
L
L
E
C
Y
F
T
R
S
F
Y
K
H
I
L
G
K
S
V
R
Y
T
D
M
E
S
E
D
Y
H
F
Y
Q
G
L
V
Y
L
L
E
N
D
V
S
T
L
G
Y
D
L
T
F
S
T
E
V
Q
E
F
G
V
C
E
V
R
D
L
K
P
N
G
A
N
I
L
V
T
E
E
N
K
K
E
Y
V
H
L
V
C
Q
M
R
M
T
G
A
I
R
K
Q
L
A
A
F
L
E
G
F
Y
E
I
I
P
K
R
L
I
S
I
F
T
E
Q
E
L
E
L
L
I
S
G
L
P
T
I
D
I
D
D
L
K
S
N
T
E
Y
H
-
K
-
Y
Q
S
N
S
I
Q
I
Q
W
F
W
R
A
L
R
S
F
D
Q
A
D
R
A
K
F
L
Q
F
V
T
G
T
S
K
V
P
L
Q
G
F
A
A
L
E
G
M
N
G
I
Q
K
F
Q
I
H
R
D
D
-
R
S
T
D
R
L
P
S
A
H
T
C
F
N
Q
L
D
L
P
A
Y
E
S
F
E
K
L
R
H
M
L
L
L
A
I
Q
E
C
S
E
G
F
G
--
29
HHSearch
72.37
43%
-84
- C2 -
-
3G1N
-
HUWE1_HUMAN
A:
[27-380]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
K
E
D
M
A
V
H
V
R
R
D
H
V
F
E
D
S
Y
R
E
L
H
R
K
S
-
P
E
E
-
M
K
N
R
L
Y
I
V
F
E
G
E
E
G
Q
D
A
G
G
L
L
R
E
W
Y
M
I
I
S
R
E
M
F
N
P
M
Y
A
L
F
R
T
S
P
G
D
R
V
T
Y
T
I
N
P
S
S
H
C
-
N
P
N
H
L
S
Y
F
K
F
V
G
R
I
V
A
K
A
V
Y
D
N
R
L
L
E
C
Y
F
T
R
S
F
Y
K
H
I
L
G
K
S
V
R
Y
T
D
M
E
S
E
D
Y
H
F
Y
Q
G
L
V
Y
L
L
E
N
D
V
S
T
L
G
Y
D
L
T
F
S
T
E
V
Q
E
F
G
V
C
E
V
R
D
L
K
P
N
G
A
N
I
L
V
T
E
E
N
K
K
E
Y
V
H
L
V
C
Q
M
R
M
T
G
A
I
R
K
Q
L
A
A
F
L
E
G
F
Y
E
I
I
P
K
R
L
I
S
I
F
T
E
Q
E
L
E
L
L
I
S
G
L
P
T
I
D
I
D
D
L
K
S
N
T
E
Y
H
-
K
-
Y
Q
S
N
S
I
Q
I
Q
W
F
W
R
A
L
R
S
F
D
Q
A
D
R
A
K
F
L
Q
F
V
T
G
T
S
K
V
P
L
Q
G
F
A
A
L
E
G
M
N
G
I
Q
K
F
Q
I
H
R
D
D
R
S
T
D
R
-
L
P
S
A
H
T
C
F
N
Q
L
D
L
P
A
Y
E
S
F
E
K
L
R
H
M
L
L
L
A
I
Q
E
--------
13
PsiBlast_PDB
72.12
52%
-105
- C2 -
-
5HPL
-
RSP5_YEAST
A:
[434-803]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
R
R
K
V
I
Y
F
R
S
-
Q
P
A
-
L
---
R
I
L
P
G
Q
C
H
I
K
V
R
R
K
N
I
F
E
D
A
Y
Q
E
I
M
R
Q
T
-
P
E
D
-
L
K
K
R
L
M
I
K
F
D
G
E
E
G
L
D
Y
G
G
V
S
R
E
F
F
F
L
L
S
H
E
M
F
N
P
F
Y
C
L
F
E
Y
S
A
Y
D
N
Y
T
I
Q
I
N
P
N
S
G
I
-
N
P
E
H
L
N
Y
F
K
F
I
G
R
V
V
G
L
G
V
F
H
R
R
F
L
D
A
F
F
V
G
A
L
Y
K
M
M
L
R
K
K
V
V
L
Q
D
M
E
G
V
D
A
E
V
Y
N
S
L
N
W
M
L
E
N
S
I
D
G
V
-
L
D
L
T
F
S
A
D
D
E
R
F
G
E
V
V
T
V
D
L
K
P
D
G
R
N
I
E
V
T
D
G
N
K
K
E
Y
V
E
L
Y
T
Q
W
R
I
V
D
R
V
Q
E
Q
F
K
A
F
M
D
G
F
N
E
L
I
P
E
D
L
V
T
V
F
D
E
R
E
L
E
L
L
I
G
G
I
A
E
I
D
I
E
D
W
K
K
H
T
D
Y
R
-
G
-
Y
Q
E
S
D
E
V
I
Q
W
F
W
K
C
V
S
E
W
D
N
E
Q
R
A
R
L
L
Q
F
T
T
G
T
S
R
I
P
V
N
G
F
K
D
L
Q
G
S
D
G
P
R
R
F
T
I
E
K
A
G
-
E
V
Q
Q
-
L
P
K
S
H
T
C
F
N
R
V
D
L
P
Q
Y
V
D
Y
D
S
M
K
Q
K
L
T
L
A
V
E
E
-
T
------
28
HHSearch
71.76
52%
-106
- C2 -
-
5HPL
-
RSP5_YEAST
B:
[433-802]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
F
R
R
K
V
I
Y
F
R
S
-
Q
P
A
-
L
---
R
I
L
P
G
Q
C
H
I
K
V
R
R
K
N
I
F
E
D
A
Y
Q
E
I
M
R
Q
T
-
P
E
D
-
L
K
K
R
L
M
I
K
F
D
G
E
E
G
L
D
Y
G
G
V
S
R
E
F
F
F
L
L
S
H
E
M
F
N
P
F
Y
C
L
F
E
Y
S
A
Y
D
N
Y
T
I
Q
I
N
P
N
S
G
I
-
N
P
E
H
L
N
Y
F
K
F
I
G
R
V
V
G
L
G
V
F
H
R
R
F
L
D
A
F
F
V
G
A
L
Y
K
M
M
L
R
K
K
V
V
L
Q
D
M
E
G
V
D
A
E
V
Y
N
S
L
N
W
M
L
E
N
S
I
D
G
-
V
L
D
L
T
F
S
A
D
D
E
R
F
G
E
V
V
T
V
D
L
K
P
D
G
R
N
I
E
V
T
D
G
N
K
K
E
Y
V
E
L
Y
T
Q
W
R
I
V
D
R
V
Q
E
Q
F
K
A
F
M
D
G
F
N
E
L
I
P
E
D
L
V
T
V
F
D
E
R
E
L
E
L
L
I
G
G
I
A
E
I
D
I
E
D
W
K
K
H
T
D
Y
R
-
G
-
Y
Q
E
S
D
E
V
I
Q
W
F
W
K
C
V
S
E
W
D
N
E
Q
R
A
R
L
L
Q
F
T
T
G
T
S
R
I
P
V
N
G
F
K
D
L
Q
G
S
D
G
P
R
R
F
T
I
E
K
A
G
-
E
V
Q
Q
-
L
P
K
S
H
T
C
F
N
R
V
D
L
P
Q
Y
V
D
Y
D
S
M
K
Q
K
L
T
L
A
V
E
E
--------
6
PsiBlast_PDB
71.65
81%
-7
- C2 -
-
5HPS
-
WWP1_HUMAN
A:
[541-917]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------I
A
Y
E
R
G
F
R
W
K
L
A
H
F
R
Y
-
L
C
Q
-
S
---
N
A
L
P
S
H
V
K
I
N
V
S
R
Q
T
L
F
E
D
S
F
Q
Q
I
M
A
L
K
-
P
Y
D
-
L
R
R
R
L
Y
V
I
F
R
G
E
E
---
Y
G
G
L
A
R
E
W
F
F
L
L
S
H
E
V
L
N
P
M
Y
C
L
F
E
Y
A
G
K
N
N
Y
C
L
Q
I
N
P
A
S
T
I
-
N
P
D
H
L
S
Y
F
C
F
I
G
R
F
I
A
M
A
L
F
H
G
K
F
I
D
T
G
F
S
L
P
F
Y
K
R
M
L
S
K
K
L
T
I
K
D
L
E
S
I
D
T
E
F
Y
N
S
L
I
W
I
R
D
N
N
I
E
E
C
G
L
E
M
Y
F
S
V
D
M
E
I
L
G
K
V
T
S
H
D
L
K
L
G
G
S
N
I
L
V
T
E
E
N
K
D
E
Y
I
G
L
M
T
E
W
R
F
S
R
G
V
Q
E
Q
T
K
A
F
L
D
G
F
N
E
V
V
P
L
Q
W
L
Q
Y
F
D
E
K
E
L
E
V
M
L
C
G
M
Q
E
V
D
L
A
D
W
Q
R
N
T
V
Y
R
-
H
-
Y
T
R
N
S
K
Q
I
I
W
F
W
Q
F
V
K
E
T
D
N
E
V
R
M
R
L
L
Q
F
V
T
G
T
C
R
L
P
L
G
G
F
A
E
L
M
G
S
N
G
P
Q
K
F
C
I
E
K
V
G
-
K
D
T
W
-
L
P
R
S
H
T
C
F
N
R
L
D
L
P
P
Y
K
S
Y
E
Q
L
K
E
K
L
L
F
A
I
E
E
-
T
E
-----
1
PsiBlast_PDB
70.55
70%
0
- C2 -
-
5XMC
-
ITCH_MOUSE
A:
[145-717]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
--
L
P
P
G
W
E
Q
R
V
D
Q
H
G
R
V
Y
Y
V
D
H
V
E
K
R
T
T
W
D
R
P
EP
L
P
P
G
W
E
R
R
V
D
N
M
G
R
I
Y
Y
V
D
H
F
T
R
T
T
T
W
Q
R
P
T
L
E
S
V
R
N
Y
E
Q
W
Q
L
Q
R
S
Q
L
Q
G
A
M
Q
Q
F
N
Q
R
F
I
Y
-------------------------------------------------------------------------------------------------------------------------------
A
Y
V
R
D
F
K
A
K
V
Q
Y
F
R
F
-
W
C
Q
-
Q
---
L
A
M
P
Q
H
I
K
I
T
V
T
R
K
T
L
F
E
D
S
F
Q
Q
I
M
S
F
S
-
P
Q
D
-
L
R
R
R
L
W
V
I
F
P
-----
D
Y
G
G
V
A
R
E
W
F
F
L
L
S
H
E
V
L
N
P
M
Y
C
L
F
E
Y
A
--
D
N
Y
C
L
Q
I
N
P
A
S
Y
I
-
N
P
D
H
L
K
Y
F
R
F
I
G
R
F
I
A
M
A
L
F
H
G
K
F
I
D
T
G
F
S
L
P
F
Y
K
R
I
L
N
K
P
V
G
L
K
D
L
E
S
I
D
P
E
F
Y
N
S
L
I
W
V
----------------------------------------------------
W
R
L
S
R
G
V
E
E
Q
T
Q
A
F
F
E
G
F
N
E
I
L
P
Q
Q
Y
L
Q
Y
F
D
A
K
E
L
E
V
L
L
C
G
M
Q
E
I
D
L
N
D
W
Q
R
H
A
I
Y
--
H
-
Y
T
R
T
--
Q
I
M
W
F
W
Q
F
V
K
E
I
D
N
E
K
R
M
R
L
L
Q
F
V
T
G
T
C
R
L
P
V
G
G
F
A
D
L
M
G
S
N
G
P
Q
K
F
C
I
E
K
V
G
-
K
E
N
W
-
L
P
R
S
H
T
C
F
N
R
L
D
L
P
P
Y
K
S
Y
E
Q
L
K
E
K
L
L
F
A
I
E
E
-
T
E
-----
23
HHSearch
67.70
42%
11
- C2 -
-
5LP8
-
HUWE1_HUMAN
A:
[68-448]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
F
D
V
K
R
K
Y
F
R
Q
-
E
L
E
-
R
L
D
E
G
L
R
K
E
D
M
A
V
H
V
R
R
D
H
V
F
E
D
S
Y
R
E
L
H
R
K
S
-
P
E
E
-
M
K
N
R
L
Y
I
V
F
E
G
E
E
G
Q
D
A
G
G
L
L
R
E
W
Y
M
I
I
S
R
E
M
F
N
P
M
Y
A
L
F
R
T
S
P
G
D
R
V
T
Y
T
I
N
P
S
S
H
C
-
N
P
N
H
L
S
Y
F
K
F
V
G
R
I
V
A
K
A
V
Y
D
N
R
L
L
E
C
Y
F
T
R
S
F
Y
K
H
I
L
G
K
S
V
R
Y
T
D
M
E
S
E
D
Y
H
F
Y
Q
G
L
V
Y
L
L
E
N
D
V
S
T
L
G
Y
D
L
T
F
S
T
E
V
Q
E
F
G
V
C
E
V
R
D
L
K
P
N
G
A
N
I
L
V
T
E
E
N
K
K
E
Y
V
H
L
V
C
Q
M
R
M
T
G
A
I
R
K
Q
L
A
A
F
L
E
G
F
Y
E
I
I
P
K
R
L
I
S
I
F
T
E
Q
E
L
E
L
L
I
S
G
L
P
T
I
D
I
D
D
L
K
S
N
T
E
Y
H
-
K
-
Y
Q
S
N
S
I
Q
I
Q
W
F
W
R
A
L
R
S
F
D
Q
A
D
R
A
K
F
L
Q
F
V
T
G
T
S
K
V
P
L
Q
G
F
A
A
L
E
G
M
N
G
I
Q
K
F
Q
I
H
R
D
D
R
S
T
D
R
-
L
P
S
A
H
T
C
F
N
Q
L
D
L
P
A
Y
E
S
F
E
K
L
R
H
M
L
L
L
A
I
Q
E
C
S
E
G
F
G
--
32
HHSearch
64.37
53%
9
- C2 -
-
2ONI
-
NED4L_HUMAN
A:
[17-391]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
G
S
R
E
F
K
Q
K
Y
D
Y
F
R
K
-
K
L
K
K
P
---
A
D
I
P
N
R
F
E
M
K
L
H
R
N
N
I
F
E
E
S
Y
R
R
I
M
S
V
K
R
P
D
V
-
L
K
A
R
L
W
I
E
F
E
-
E
K
G
L
D
Y
G
G
V
A
R
E
W
F
F
L
L
S
K
E
M
F
N
P
Y
Y
G
L
F
E
Y
S
A
T
D
N
Y
T
L
Q
I
N
P
N
S
G
L
C
N
E
D
H
L
S
Y
F
T
F
I
G
R
V
A
G
L
A
V
F
H
G
K
L
L
D
G
F
F
I
R
P
F
Y
K
M
M
L
G
K
Q
I
T
L
N
D
M
E
S
V
D
S
E
Y
Y
N
S
L
K
W
I
L
E
N
D
P
T
E
--
L
D
L
M
F
C
I
D
E
E
N
F
G
Q
T
Y
Q
V
D
L
K
P
N
G
S
E
I
M
V
T
N
E
N
K
R
E
Y
I
D
L
V
I
Q
W
R
F
V
N
R
V
Q
K
Q
M
N
A
F
L
E
G
F
T
E
L
L
P
I
D
L
I
K
I
F
D
E
N
E
L
E
L
L
M
C
G
L
G
D
V
D
V
N
D
W
R
Q
H
S
I
Y
K
N
G
-
Y
C
P
N
H
P
V
I
Q
W
F
W
K
A
V
L
L
M
D
A
E
K
R
I
R
L
L
Q
F
V
T
G
T
S
R
V
P
M
N
G
F
A
E
L
Y
G
S
N
G
P
Q
L
F
T
I
E
Q
W
G
-
S
P
E
K
-
L
P
R
A
H
T
C
F
N
R
L
D
L
P
P
Y
E
T
F
E
D
L
R
E
K
L
L
M
A
V
E
---------
18
PsiBlast_PDB
62.33
53%
9
- C2 -
-
2XBF
4
A:
[6-379]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
Y
K
R
K
Y
E
F
F
R
R
K
L
K
K
-
Q
---
N
D
I
P
N
K
F
E
M
K
L
R
R
A
T
V
L
E
D
S
Y
R
R
I
M
G
V
K
-
R
A
D
F
L
K
A
R
L
W
I
E
F
D
G
E
K
G
L
D
Y
G
G
V
A
R
E
W
F
F
L
I
S
K
E
M
F
N
P
Y
Y
G
L
F
E
Y
S
A
T
D
N
Y
T
L
Q
I
N
P
N
S
G
L
C
N
E
D
H
L
S
Y
F
K
F
I
G
R
V
A
G
M
A
V
Y
H
G
K
L
L
D
G
F
F
I
R
P
F
Y
K
M
M
L
H
K
P
I
T
L
H
D
M
E
S
V
D
S
E
Y
Y
N
S
L
R
W
I
L
E
N
D
P
T
E
--
L
D
L
R
F
I
I
D
E
E
L
F
G
Q
T
H
Q
H
E
L
K
N
G
G
S
E
I
V
V
T
N
K
N
K
K
E
Y
I
Y
L
V
I
Q
W
R
F
V
N
R
I
Q
K
Q
M
A
A
F
K
E
G
F
F
E
L
I
P
Q
D
L
I
K
I
F
D
E
N
E
L
E
L
L
M
C
G
L
G
D
V
D
V
N
D
W
R
E
H
T
K
Y
K
-
N
G
Y
S
A
N
H
Q
V
I
Q
W
F
W
K
A
V
L
M
M
D
S
E
K
R
I
R
L
L
Q
F
V
T
G
T
S
R
V
P
M
N
G
F
A
E
L
Y
G
S
N
G
P
Q
S
F
T
V
E
Q
W
G
-
T
P
E
K
-
L
P
R
A
H
T
C
F
N
R
L
D
L
P
P
Y
E
S
F
E
E
L
W
D
K
L
Q
M
A
I
E
N
-
T
------