@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : CBL_MOUSE: (2018-07-13 )
MAGNVKKSSGAGGGGSGGSGAGGLIGLMKDAFQPHHHHHHLSPHPPCTVDKKMVEKCWKLMDKVVRLCQNPKLALKNSPPYILDLLPDTYQHLRTVLSRYEGKMETLGENEYFRVFMENLMKKTKQTISLFKEGKERMYEENSQPRRNLTKLSLIFSHMLAELKGIFPSGLFQGDTFRITKADAAEFWRKAFGEKTIVPWKSFRQALHEVHPISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWSSLLRNWNSLAVTHPGYMAFLTYDEVKARLQKFIHKPGSYIFRLSCTRLGQWAIGYVTADGNILQTIPHNKPLFQALIDGFREGFYLFPDGRNQNPDLTGLCEPTPQDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTSWQESEGQGCPFCRCEIKGTEPIVVDPFDPRGSGSLLRQGAEGAPSPNYDDDDDERADDSLFMMKELAGAKVERPSSPFSMAPQASLPPVPPRLDLLQQRAPVPASTSVLGTASKAASGSLHKDKPLPIPPTLRDLPPPPPPDRPYSVGAETRPQRRPLPCTPGDCPSRDKLPPVPSSRPGDSWLSRPIPKVPVATPNPGDPWNGRELTNRHSLPFSLPSQMEPRADVPRLGSTFSLDTSMTMNSSPVAGPESEHPKIKPSSSANAIYSLAARPLPMPKLPPGEQGESEEDTEYMTPTSRPVGVQKPEPKRPLEATQSSRACDCDQQIDSCTYEAMYNIQSQALSVAENSASGEGNLATAHTSTGPEESENEDDGYDVPKPPVPAVLARRTLSDISNASSSFGWLSLDGDPTNFNEGSQVPERPPKPFPRRINSERKASSYQQGGGATANPVATAPSPQLSSEIERLMSQGYSYQDIQKALVIAHNNIEMAKNILREFVSISSPAHVAT
Atome Classification :
(20 SA)
.........10........20........30........40......-..50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MAGNVKKSSGAGGGGSGGSGA
G
G
L
I
G
L
M
K
D
AFQPHHHHHHLSPHPPC-TV
D
K
K
M
V
E
K
C
W
K
L
M
D
K
V
V
R
L
CQNP
K
L
ALKNSP
P
Y
I
L
DLLP
D
T
Y
Q
H
L
R
T
V
L
S
RYE
G
K
M
E
TLGE
N
E
Y
F
R
V
F
M
E
N
L
M
K
K
T
K
Q
T
I
S
L
F
K
E
G
K
E
R
M
Y
EENSQP
R
R
N
L
T
K
L
S
L
I
F
S
H
M
L
A
E
L
K
G
IFPSGLFQG
D
T
F
R
I
TKA
D
A
A
E
F
W
R
K
AFGEKTIV
P
W
K
S
F
R
Q
A
L
H
E
VH
P
I
S
S
G
L
E
A
M
ALK
S
T
I
DLTCN
D
Y
I
S
V
F
E
F
D
I
F
T
R
L
F
Q
P
W
S
S
L
L
RNWN
S
L
A
VTHPG
Y
M
A
F
L
T
Y
D
E
V
K
A
R
L
Q
K
F
I
HKPG
S
Y
I
F
R
L
SCTRLGQ
W
A
I
G
Y
V
TADG
N
I
L
Q
TIPHN
K
P
L
F
Q
A
L
I
D
G
F
RE
G
F
Y
LFPDGRNQNPDLTGLCEPT
P
Q
D
H
I
K
V
T
Q
E
Q
Y
E
L
Y
CEMG
S
T
F
Q
L
C
K
I
C
AENDK
D
V
K
IEPC
G
H
L
M
C
T
S
C
L
T
S
W
QESEGQGC
P
F
C
R
C
E
IKGTE
P
I
V
VDPFDPRG
S
G
S
L
L
R
QGAEGAPSPNYDDDDDERAD
D
S
L
F
M
M
K
E
LAGAKVERPSSPFSMAPQASLPPVP
P
R
L
D
L
L
Q
QRAPVPAST
S
V
LGTASKAASGSLHKDKPLPIPP
T
L
RDLPPPPPPDRPYSVGAETRPQRRPLPCTPGDCPSRDKLPPVPSSRPG
D
S
W
LSRPIPKVPVATPNPGDPWNGRELTNRHSLPFSLPSQMEPRADVPRLGS
T
F
SLDTSMTMNSSPVAGPESEHPKIKPSSSA
N
A
I
Y
S
LAARPLPMPKLPPGEQGESEEDTEYMTPTSRPVGVQKPEPKRP
L
E
ATQSSRACD
C
D
Q
Q
I
D
S
C
T
Y
E
A
M
Y
N
I
Q
S
Q
A
L
S
VAENSASGEG
N
L
A
T
AHTSTGPEESENEDDGYDVPKP
P
V
P
A
V
L
A
R
R
T
L
S
D
I
SNASSS
F
G
W
L
S
LDGDPTNFNEGSQVPERPPKPF
P
R
RIN
S
E
RKASSYQQGGGATANPVATAPS
P
Q
L
S
S
E
I
E
R
L
M
SQGY
S
Y
Q
D
I
Q
K
A
L
V
IAHN
N
I
E
M
A
K
N
I
L
R
E
F
V
SISSPAHVAT
6
PsiBlast_PDB
91.71
98%
-129
- C1 -
-
4A4B
-
CBL_HUMAN
A:
[4-391]
---------------------------------------------
P
G
-
T
V
D
K
K
M
V
E
K
C
W
K
L
M
D
K
V
V
R
L
C
Q
N
P
K
L
A
L
K
N
S
P
P
Y
I
L
D
L
L
P
D
T
Y
Q
H
L
R
T
I
L
S
R
Y
E
G
K
M
E
T
L
G
E
N
E
Y
F
R
V
F
M
E
N
L
M
K
K
T
K
Q
T
I
S
L
F
K
E
G
K
E
R
M
Y
E
E
N
S
Q
P
R
R
N
L
T
K
L
S
L
I
F
S
H
M
L
A
E
L
K
G
I
F
P
S
G
L
F
Q
G
D
T
F
R
I
T
K
A
D
A
A
E
F
W
R
K
A
F
G
E
K
T
I
V
P
W
K
S
F
R
Q
A
L
H
E
V
H
P
I
S
S
G
L
E
A
M
A
L
K
S
T
I
D
L
T
C
N
D
Y
I
S
V
F
E
F
D
I
F
T
R
L
F
Q
P
W
S
S
L
L
R
N
W
N
S
L
A
V
T
H
P
G
Y
M
A
F
L
T
Y
D
E
V
K
A
R
L
Q
K
F
I
H
K
P
G
S
Y
I
F
R
L
S
C
T
R
L
G
Q
W
A
I
G
Y
V
T
A
D
G
N
I
L
Q
T
I
P
H
N
K
P
L
F
Q
A
L
I
D
G
F
R
E
G
F
Y
L
F
P
D
G
R
N
Q
N
P
D
L
T
G
L
C
E
P
T
P
Q
D
H
I
K
V
T
Q
E
Q
F
E
L
Y
C
E
M
G
S
T
F
Q
L
C
K
I
C
A
E
N
D
K
D
V
K
I
E
P
C
G
H
L
M
C
T
S
C
L
T
S
W
Q
E
S
E
G
Q
G
C
P
F
C
R
C
E
I
K
G
T
E
P
I
V
V
D
P
F
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
90.77
99%
-125
- C1 -
-
4A4C
-
CBL_HUMAN
A:
[4-391]
---------------------------------------------
P
G
-
T
V
D
K
K
M
V
E
K
C
W
K
L
M
D
K
V
V
R
L
C
Q
N
P
K
L
A
L
K
N
S
P
P
Y
I
L
D
L
L
P
D
T
Y
Q
H
L
R
T
I
L
S
R
Y
E
G
K
M
E
T
L
G
E
N
E
Y
F
R
V
F
M
E
N
L
M
K
K
T
K
Q
T
I
S
L
F
K
E
G
K
E
R
M
Y
E
E
N
S
Q
P
R
R
N
L
T
K
L
S
L
I
F
S
H
M
L
A
E
L
K
G
I
F
P
S
G
L
F
Q
G
D
T
F
R
I
T
K
A
D
A
A
E
F
W
R
K
A
F
G
E
K
T
I
V
P
W
K
S
F
R
Q
A
L
H
E
V
H
P
I
S
S
G
L
E
A
M
A
L
K
S
T
I
D
L
T
C
N
D
Y
I
S
V
F
E
F
D
I
F
T
R
L
F
Q
P
W
S
S
L
L
R
N
W
N
S
L
A
V
T
H
P
G
Y
M
A
F
L
T
Y
D
E
V
K
A
R
L
Q
K
F
I
H
K
P
G
S
Y
I
F
R
L
S
C
T
R
L
G
Q
W
A
I
G
Y
V
T
A
D
G
N
I
L
Q
T
I
P
H
N
K
P
L
F
Q
A
L
I
D
G
F
R
E
G
F
Y
L
F
P
D
G
R
N
Q
N
P
D
L
T
G
L
C
E
P
T
P
Q
D
H
I
K
V
T
Q
E
Q
Y
E
L
Y
C
E
M
G
S
T
F
Q
L
C
K
I
C
A
E
N
D
K
D
V
K
I
E
P
C
G
H
L
M
C
T
S
C
L
T
S
W
Q
E
S
E
G
Q
G
C
P
F
C
R
C
E
I
K
G
T
E
P
I
V
V
D
P
F
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
89.63
98%
-130
* C1 *
-
5O76
-
CBL_HUMAN
A:
[6-390]
------------------------------------------------
T
V
D
K
K
M
V
E
K
C
W
K
L
M
D
K
V
V
R
L
C
Q
N
P
K
L
A
L
K
N
S
P
P
Y
I
L
D
L
L
P
D
T
Y
Q
H
L
R
T
I
L
S
R
Y
E
G
K
M
E
T
L
G
E
N
E
Y
F
R
V
F
M
E
N
L
M
K
K
T
K
Q
T
I
S
L
F
K
E
G
K
E
R
M
Y
E
E
N
S
Q
P
R
R
N
L
T
K
L
S
L
I
F
S
H
M
L
A
E
L
K
G
I
F
P
S
G
L
F
Q
G
D
T
F
R
I
T
K
A
D
A
A
E
F
W
R
K
A
F
G
E
K
T
I
V
P
W
K
S
F
R
Q
A
L
H
E
V
H
P
I
S
S
G
L
E
A
M
A
L
K
S
T
I
D
L
T
C
N
D
Y
I
S
V
F
E
F
D
I
F
T
R
L
F
Q
P
W
S
S
L
L
R
N
W
N
S
L
A
V
T
H
P
G
Y
M
A
F
L
T
Y
D
E
V
K
A
R
L
Q
K
F
I
H
K
P
G
S
Y
I
F
R
L
S
C
T
R
L
G
Q
W
A
I
G
Y
V
T
A
D
G
N
I
L
Q
T
I
P
H
N
K
P
L
F
Q
A
L
I
D
G
F
R
E
G
F
Y
L
F
P
D
G
R
N
Q
N
P
D
L
T
G
L
C
E
P
T
P
Q
D
H
I
K
V
T
Q
E
Q
F
E
L
Y
C
E
M
G
S
T
F
Q
L
C
K
I
C
A
E
N
D
K
D
V
K
I
E
P
C
G
H
L
M
C
T
S
C
L
T
S
W
Q
E
S
E
G
Q
G
C
P
F
C
R
C
E
I
K
G
T
E
P
I
V
V
D
P
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
89.60
99%
-136
- C1 -
-
5HKX
1
CBL_HUMAN
A:
[6-386]
----------------------------------------------
G
-
T
V
D
K
K
M
V
E
K
C
W
K
L
M
D
K
V
V
R
L
C
Q
N
P
K
L
A
L
K
N
S
P
P
Y
I
L
D
L
L
P
D
T
Y
Q
H
L
R
T
I
L
S
R
Y
E
G
K
M
E
T
L
G
E
N
E
Y
F
R
V
F
M
E
N
L
M
K
K
T
K
Q
T
I
S
L
F
K
E
G
K
E
R
M
Y
E
E
N
S
Q
P
R
R
N
L
T
K
L
S
L
I
F
S
H
M
L
A
E
L
K
G
I
F
P
S
G
L
F
Q
G
D
T
F
R
I
T
K
A
D
A
A
E
F
W
R
K
A
F
G
E
K
T
I
V
P
W
K
S
F
R
Q
A
L
H
E
V
H
P
I
S
S
G
L
E
A
M
A
L
K
S
T
I
D
L
T
C
N
D
Y
I
S
V
F
E
F
D
I
F
T
R
L
F
Q
P
W
S
S
L
L
R
N
W
N
S
L
A
V
T
H
P
G
Y
M
A
F
L
T
Y
D
E
V
K
A
R
L
Q
K
F
I
H
K
P
G
S
Y
I
F
R
L
S
C
T
R
L
G
Q
W
A
I
G
Y
V
T
A
D
G
N
I
L
Q
T
I
P
H
N
K
P
L
F
Q
A
L
I
D
G
F
R
E
G
F
Y
L
F
P
D
G
R
N
Q
N
P
D
L
T
G
L
C
E
--------
V
T
Q
E
Q
Y
E
L
E
C
E
M
G
S
T
F
Q
L
C
K
I
C
A
E
N
D
K
D
V
K
I
E
P
C
G
H
L
M
C
T
S
C
L
T
S
W
Q
E
S
E
G
Q
G
C
P
F
C
R
C
E
I
K
G
T
E
P
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
89.43
99%
-132
- C1 -
-
5J3X
-
CBL_HUMAN
A:
[3-391]
--------------------------------------------
P
P
G
-
T
V
D
K
K
M
V
E
K
C
W
K
L
M
D
K
V
V
R
L
C
Q
N
P
K
L
A
L
K
N
S
P
P
Y
I
L
D
L
L
P
D
T
Y
Q
H
L
R
T
I
L
S
R
Y
E
G
K
M
E
T
L
G
E
N
E
Y
F
R
V
F
M
E
N
L
M
K
K
T
K
Q
T
I
S
L
F
K
E
G
K
E
R
M
Y
E
E
N
S
Q
P
R
R
N
L
T
K
L
S
L
I
F
S
H
M
L
A
E
L
K
G
I
F
P
S
G
L
F
Q
G
D
T
F
R
I
T
K
A
D
A
A
E
F
W
R
K
A
F
G
E
K
T
I
V
P
W
K
S
F
R
Q
A
L
H
E
V
H
P
I
S
S
G
L
E
A
M
A
L
K
S
T
I
D
L
T
C
N
D
Y
I
S
V
F
E
F
D
I
F
T
R
L
F
Q
P
W
S
S
L
L
R
N
W
N
S
L
A
V
T
H
P
G
Y
M
A
F
L
T
Y
D
E
V
K
A
R
L
Q
K
F
I
H
K
P
G
S
Y
I
F
R
L
S
C
T
R
L
G
Q
W
A
I
G
Y
V
T
A
D
G
N
I
L
Q
T
I
P
H
N
K
P
L
F
Q
A
L
I
D
G
F
R
E
G
F
Y
L
F
P
D
G
R
N
Q
N
P
D
L
T
G
L
C
E
P
T
---
H
I
K
V
T
Q
E
Q
Y
E
L
F
C
E
M
G
S
T
F
Q
L
C
K
I
C
A
E
N
D
K
D
V
K
I
E
P
C
G
H
L
M
C
T
S
C
L
T
S
W
Q
E
S
E
G
Q
G
C
P
F
C
R
C
E
I
K
G
T
E
P
I
V
V
D
P
F
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
89.25
98%
-135
- C1 -
-
5HKX
1
CBL_HUMAN
A:
[5-386]
---------------------------------------------
P
G
-
T
V
D
K
K
M
V
E
K
C
W
K
L
M
D
K
V
V
R
L
C
Q
N
P
K
L
A
L
K
N
S
P
P
Y
I
L
D
L
L
P
D
T
Y
Q
H
L
R
T
I
L
S
R
Y
E
G
K
M
E
T
L
G
E
N
E
Y
F
R
V
F
M
E
N
L
M
K
K
T
K
Q
T
I
S
L
F
K
E
G
K
E
R
M
Y
E
E
N
S
Q
P
R
R
N
L
T
K
L
S
L
I
F
S
H
M
L
A
E
L
K
G
I
F
P
S
G
L
F
Q
G
D
T
F
R
I
T
K
A
D
A
A
E
F
W
R
K
A
F
G
E
K
T
I
V
P
W
K
S
F
R
Q
A
L
H
E
V
H
P
I
S
S
G
L
E
A
M
A
L
K
S
T
I
D
L
T
C
N
D
Y
I
S
V
F
E
F
D
I
F
T
R
L
F
Q
P
W
S
S
L
L
R
N
W
N
S
L
A
V
T
H
P
G
Y
M
A
F
L
T
Y
D
E
V
K
A
R
L
Q
K
F
I
H
K
P
G
S
Y
I
F
R
L
S
C
T
R
L
G
Q
W
A
I
G
Y
V
T
A
D
G
N
I
L
Q
T
I
P
H
N
K
P
L
F
Q
A
L
I
D
G
F
R
E
G
F
Y
L
F
P
D
G
R
N
Q
N
P
D
L
T
G
L
C
E
--------
V
T
Q
E
Q
Y
E
L
E
C
E
M
G
S
T
F
Q
L
C
K
I
C
A
E
N
D
K
D
V
K
I
E
P
C
G
H
L
M
C
T
S
C
L
T
S
W
Q
E
S
E
G
Q
G
C
P
F
C
R
C
E
I
K
G
T
E
P
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
88.72
99%
-126
- C1 -
-
1FBV
-
CBL_HUMAN
A:
[3-386]
----------------------------------------------
G
-
T
V
D
K
K
M
V
E
K
C
W
K
L
M
D
K
V
V
R
L
C
Q
N
P
K
L
A
L
K
N
S
P
P
Y
I
L
D
L
L
P
D
T
Y
Q
H
L
R
T
I
L
S
R
Y
E
G
K
M
E
T
L
G
E
N
E
Y
F
R
V
F
M
E
N
L
M
K
K
T
K
Q
T
I
S
L
F
K
E
G
K
E
R
M
Y
E
E
N
S
Q
P
R
R
N
L
T
K
L
S
L
I
F
S
H
M
L
A
E
L
K
G
I
F
P
S
G
L
F
Q
G
D
T
F
R
I
T
K
A
D
A
A
E
F
W
R
K
A
F
G
E
K
T
I
V
P
W
K
S
F
R
Q
A
L
H
E
V
H
P
I
S
S
G
L
E
A
M
A
L
K
S
T
I
D
L
T
C
N
D
Y
I
S
V
F
E
F
D
I
F
T
R
L
F
Q
P
W
S
S
L
L
R
N
W
N
S
L
A
V
T
H
P
G
Y
M
A
F
L
T
Y
D
E
V
K
A
R
L
Q
K
F
I
H
K
P
G
S
Y
I
F
R
L
S
C
T
R
L
G
Q
W
A
I
G
Y
V
T
A
D
G
N
I
L
Q
T
I
P
H
N
K
P
L
F
Q
A
L
I
D
G
F
R
E
G
F
Y
L
F
P
D
G
R
N
Q
N
P
D
L
T
G
L
C
E
P
T
P
Q
D
H
I
K
V
T
Q
E
Q
Y
E
L
Y
C
E
M
G
S
T
F
Q
L
C
K
I
C
A
E
N
D
K
D
V
K
I
E
P
C
G
H
L
M
C
T
S
C
L
T
S
W
Q
E
S
E
G
Q
G
C
P
F
C
R
C
E
I
K
G
T
E
P
I
V
V
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
88.48
99%
-123
- C1 -
-
1FBV
-
CBL_HUMAN
A:
[1-388]
--------------------------------------------
P
P
G
-
T
V
D
K
K
M
V
E
K
C
W
K
L
M
D
K
V
V
R
L
C
Q
N
P
K
L
A
L
K
N
S
P
P
Y
I
L
D
L
L
P
D
T
Y
Q
H
L
R
T
I
L
S
R
Y
E
G
K
M
E
T
L
G
E
N
E
Y
F
R
V
F
M
E
N
L
M
K
K
T
K
Q
T
I
S
L
F
K
E
G
K
E
R
M
Y
E
E
N
S
Q
P
R
R
N
L
T
K
L
S
L
I
F
S
H
M
L
A
E
L
K
G
I
F
P
S
G
L
F
Q
G
D
T
F
R
I
T
K
A
D
A
A
E
F
W
R
K
A
F
G
E
K
T
I
V
P
W
K
S
F
R
Q
A
L
H
E
V
H
P
I
S
S
G
L
E
A
M
A
L
K
S
T
I
D
L
T
C
N
D
Y
I
S
V
F
E
F
D
I
F
T
R
L
F
Q
P
W
S
S
L
L
R
N
W
N
S
L
A
V
T
H
P
G
Y
M
A
F
L
T
Y
D
E
V
K
A
R
L
Q
K
F
I
H
K
P
G
S
Y
I
F
R
L
S
C
T
R
L
G
Q
W
A
I
G
Y
V
T
A
D
G
N
I
L
Q
T
I
P
H
N
K
P
L
F
Q
A
L
I
D
G
F
R
E
G
F
Y
L
F
P
D
G
R
N
Q
N
P
D
L
T
G
L
C
E
P
T
P
Q
D
H
I
K
V
T
Q
E
Q
Y
E
L
Y
C
E
M
G
S
T
F
Q
L
C
K
I
C
A
E
N
D
K
D
V
K
I
E
P
C
G
H
L
M
C
T
S
C
L
T
S
W
Q
E
S
E
G
Q
G
C
P
F
C
R
C
E
I
K
G
T
E
P
I
V
V
D
P
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
87.79
99%
-121
- C1 -
-
2Y1N
-
CBL_HUMAN
A:
[6-389]
--------------------------------------------------
D
K
K
M
V
E
K
C
W
K
L
M
D
K
V
V
R
L
C
Q
N
P
K
L
A
L
K
N
S
P
P
Y
I
L
D
L
L
P
D
T
Y
Q
H
L
R
T
I
L
S
R
Y
E
G
K
M
E
T
L
G
E
N
E
Y
F
R
V
F
M
E
N
L
M
K
K
T
K
Q
T
I
S
L
F
K
E
G
K
E
R
M
Y
E
E
N
S
Q
P
R
R
N
L
T
K
L
S
L
I
F
S
H
M
L
A
E
L
K
G
I
F
P
S
G
L
F
Q
G
D
T
F
R
I
T
K
A
D
A
A
E
F
W
R
K
A
F
G
E
K
T
I
V
P
W
K
S
F
R
Q
A
L
H
E
V
H
P
I
S
S
G
L
E
A
M
A
L
K
S
T
I
D
L
T
C
N
D
Y
I
S
V
F
E
F
D
I
F
T
R
L
F
Q
P
W
S
S
L
L
R
N
W
N
S
L
A
V
T
H
P
G
Y
M
A
F
L
T
Y
D
E
V
K
A
R
L
Q
K
F
I
H
K
P
G
S
Y
I
F
R
L
S
C
T
R
L
G
Q
W
A
I
G
Y
V
T
A
D
G
N
I
L
Q
T
I
P
H
N
K
P
L
F
Q
A
L
I
D
G
F
R
E
G
F
Y
L
F
P
D
G
R
N
Q
N
P
D
L
T
G
L
C
E
-------
K
V
T
Q
E
Q
Y
E
L
Y
C
E
M
G
S
T
F
Q
L
C
K
I
C
A
E
N
D
K
D
V
K
I
E
P
C
G
H
L
M
C
T
S
C
L
T
S
W
Q
E
S
E
G
Q
G
C
P
F
C
R
C
E
I
K
G
T
E
P
I
V
V
D
P
F
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
86.09
98%
-151
- C1 -
-
5HKY
1
CBL_HUMAN
A:
[5-307]
---------------------------------------------
P
G
-
T
V
D
K
K
M
V
E
K
C
W
K
L
M
D
K
V
V
R
L
C
Q
N
P
K
L
A
L
K
N
S
P
P
Y
I
L
D
L
L
P
D
T
Y
Q
H
L
R
T
I
L
S
R
Y
E
G
K
M
E
T
L
G
E
N
E
Y
F
R
V
F
M
E
N
L
M
K
K
T
K
Q
T
I
S
L
F
K
E
G
K
E
R
M
Y
E
E
N
S
Q
P
R
R
N
L
T
K
L
S
L
I
F
S
H
M
L
A
E
L
K
G
I
F
P
S
G
L
F
Q
G
D
T
F
R
I
T
K
A
D
A
A
E
F
W
R
K
A
F
G
E
K
T
I
V
P
W
K
S
F
R
Q
A
L
H
E
V
H
P
I
S
S
G
L
E
A
M
A
L
K
S
T
I
D
L
T
C
N
D
Y
I
S
V
F
E
F
D
I
F
T
R
L
F
Q
P
W
S
S
L
L
R
N
W
N
S
L
A
V
T
H
P
G
Y
M
A
F
L
T
Y
D
E
V
K
A
R
L
Q
K
F
I
H
K
P
G
S
Y
I
F
R
L
S
C
T
R
L
G
Q
W
A
I
G
Y
V
T
A
D
G
N
I
L
Q
T
I
P
H
N
K
P
L
F
Q
A
L
I
D
G
F
R
E
G
F
Y
L
F
P
D
G
R
N
Q
N
P
D
L
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
85.96
99%
-147
- C1 -
-
2CBL
-
CBL_HUMAN
A:
[3-305]
----------------------------------------------
G
-
T
V
D
K
K
M
V
E
K
C
W
K
L
M
D
K
V
V
R
L
C
Q
N
P
K
L
A
L
K
N
S
P
P
Y
I
L
D
L
L
P
D
T
Y
Q
H
L
R
T
I
L
S
R
Y
E
G
K
M
E
T
L
G
E
N
E
Y
F
R
V
F
M
E
N
L
M
K
K
T
K
Q
T
I
S
L
F
K
E
G
K
E
R
M
Y
E
E
N
S
Q
P
R
R
N
L
T
K
L
S
L
I
F
S
H
M
L
A
E
L
K
G
I
F
P
S
G
L
F
Q
G
D
T
F
R
I
T
K
A
D
A
A
E
F
W
R
K
A
F
G
E
K
T
I
V
P
W
K
S
F
R
Q
A
L
H
E
V
H
P
I
S
S
G
L
E
A
M
A
L
K
S
T
I
D
L
T
C
N
D
Y
I
S
V
F
E
F
D
I
F
T
R
L
F
Q
P
W
S
S
L
L
R
N
W
N
S
L
A
V
T
H
P
G
Y
M
A
F
L
T
Y
D
E
V
K
A
R
L
Q
K
F
I
H
K
P
G
S
Y
I
F
R
L
S
C
T
R
L
G
Q
W
A
I
G
Y
V
T
A
D
G
N
I
L
Q
T
I
P
H
N
K
P
L
F
Q
A
L
I
D
G
F
R
E
G
F
Y
L
F
P
D
G
R
N
Q
N
P
D
L
T
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
85.73
98%
-153
- C1 -
-
5HKW
-
CBL_HUMAN
A:
[5-306]
---------------------------------------------
P
G
-
T
V
D
K
K
M
V
E
K
C
W
K
L
M
D
K
V
V
R
L
C
Q
N
P
K
L
A
L
K
N
S
P
P
Y
I
L
D
L
L
P
D
T
Y
Q
H
L
R
T
I
L
S
R
Y
E
G
K
M
E
T
L
G
E
N
E
Y
F
R
V
F
M
E
N
L
M
K
K
T
K
Q
T
I
S
L
F
K
E
G
K
E
R
M
Y
E
E
N
S
Q
P
R
R
N
L
T
K
L
S
L
I
F
S
H
M
L
A
E
L
K
G
I
F
P
S
G
L
F
Q
G
D
T
F
R
I
T
K
A
D
A
A
E
F
W
R
K
A
F
G
E
K
T
I
V
P
W
K
S
F
R
Q
A
L
H
E
V
H
P
I
S
S
G
L
E
A
M
A
L
K
S
T
I
D
L
T
C
N
D
Y
I
S
V
F
E
F
D
I
F
T
R
L
F
Q
P
W
S
S
L
L
R
N
W
N
S
L
A
V
T
H
P
G
Y
M
A
F
L
T
Y
D
E
V
K
A
R
L
Q
K
F
I
H
K
P
G
S
Y
I
F
R
L
S
C
T
R
L
G
Q
W
A
I
G
Y
V
T
A
D
G
N
I
L
Q
T
I
P
H
N
K
P
L
F
Q
A
L
I
D
G
F
R
E
G
F
Y
L
F
P
D
G
R
N
Q
N
P
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
85.44
99%
-149
- C1 -
-
3BUX
-
CBL_HUMAN
B:
[25-328]
--------------------------------------------
P
P
G
-
T
V
D
K
K
M
V
E
K
C
W
K
L
M
D
K
V
V
R
L
C
Q
N
P
K
L
A
L
K
N
S
P
P
Y
I
L
D
L
L
P
D
T
Y
Q
H
L
R
T
I
L
S
R
Y
E
G
K
M
E
T
L
G
E
N
E
Y
F
R
V
F
M
E
N
L
M
K
K
T
K
Q
T
I
S
L
F
K
E
G
K
E
R
M
Y
E
E
N
S
Q
P
R
R
N
L
T
K
L
S
L
I
F
S
H
M
L
A
E
L
K
G
I
F
P
S
G
L
F
Q
G
D
T
F
R
I
T
K
A
D
A
A
E
F
W
R
K
A
F
G
E
K
T
I
V
P
W
K
S
F
R
Q
A
L
H
E
V
H
P
I
S
S
G
L
E
A
M
A
L
K
S
T
I
D
L
T
C
N
D
Y
I
S
V
F
E
F
D
I
F
T
R
L
F
Q
P
W
S
S
L
L
R
N
W
N
S
L
A
V
T
H
P
G
Y
M
A
F
L
T
Y
D
E
V
K
A
R
L
Q
K
F
I
H
K
P
G
S
Y
I
F
R
L
S
C
T
R
L
G
Q
W
A
I
G
Y
V
T
A
D
G
N
I
L
Q
T
I
P
H
N
K
P
L
F
Q
A
L
I
D
G
F
R
E
G
F
Y
L
F
P
D
G
R
N
Q
N
P
D
L
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
84.35
97%
-156
- C1 -
-
3OB1
-
CBL_HUMAN
B:
[33-328]
-----------------------------------------------------
M
V
E
K
C
W
K
L
M
D
K
V
V
R
L
C
Q
N
P
K
L
A
L
K
N
S
P
P
Y
I
L
D
L
L
P
D
T
Y
Q
H
L
R
T
I
L
S
R
Y
E
G
K
M
E
T
L
G
E
N
E
Y
F
R
V
F
M
E
N
L
M
K
K
T
K
Q
T
I
S
L
F
K
E
G
K
E
R
M
Y
E
E
N
S
Q
P
R
R
N
L
T
K
L
S
L
I
F
S
H
M
L
A
E
L
K
G
I
F
P
S
G
L
F
Q
G
D
T
F
R
I
T
K
A
D
A
A
E
F
W
R
K
A
F
G
E
K
T
I
V
P
W
K
S
F
R
Q
A
L
H
E
V
H
P
I
S
S
G
L
E
A
M
A
L
K
S
T
I
D
L
T
C
N
D
Y
I
S
V
F
E
F
D
I
F
T
R
L
F
Q
P
W
S
S
L
L
R
N
W
N
S
L
A
V
T
H
P
G
Y
M
A
F
L
T
Y
D
E
V
K
A
R
L
Q
K
F
I
H
K
P
G
S
Y
I
F
R
L
S
C
T
R
L
G
Q
W
A
I
G
Y
V
T
A
D
G
N
I
L
Q
T
I
P
H
N
K
P
L
F
Q
A
L
I
D
G
F
R
E
G
F
Y
L
F
P
D
G
R
N
Q
N
P
D
L
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
84.18
97%
-155
- C1 -
-
3OB2
-
CBL_HUMAN
B:
[33-328]
-----------------------------------------------------
M
V
E
K
C
W
K
L
M
D
K
V
V
R
L
C
Q
N
P
K
L
A
L
K
N
S
P
P
Y
I
L
D
L
L
P
D
T
Y
Q
H
L
R
T
I
L
S
R
Y
E
G
K
M
E
T
L
G
E
N
E
Y
F
R
V
F
M
E
N
L
M
K
K
T
K
Q
T
I
S
L
F
K
E
G
K
E
R
M
Y
E
E
N
S
Q
P
R
R
N
L
T
K
L
S
L
I
F
S
H
M
L
A
E
L
K
G
I
F
P
S
G
L
F
Q
G
D
T
F
R
I
T
K
A
D
A
A
E
F
W
R
K
A
F
G
E
K
T
I
V
P
W
K
S
F
R
Q
A
L
H
E
V
H
P
I
S
S
G
L
E
A
M
A
L
K
S
T
I
D
L
T
C
N
D
Y
I
S
V
F
E
F
D
I
F
T
R
L
F
Q
P
W
S
S
L
L
R
N
W
N
S
L
A
V
T
H
P
G
Y
M
A
F
L
T
Y
D
E
V
K
A
R
L
Q
K
F
I
H
K
P
G
S
Y
I
F
R
L
S
C
T
R
L
G
Q
W
A
I
G
Y
V
T
A
D
G
N
I
L
Q
T
I
P
H
N
K
P
L
F
Q
A
L
I
D
G
F
R
E
G
F
Y
L
F
P
D
G
R
N
Q
N
P
D
L
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
78.79
85%
-161
- C1 -
-
3VGO
-
CBLB_HUMAN
A:
[43-339]
---------------------------------------------------
R
R
T
V
E
K
T
W
K
L
M
D
K
V
V
R
L
C
Q
N
P
K
L
Q
L
K
N
S
P
P
Y
I
L
D
I
L
P
D
T
Y
Q
H
L
R
L
I
L
S
K
Y
----
A
Q
L
S
E
N
E
Y
F
K
I
Y
I
D
S
L
M
K
K
S
K
R
A
I
R
L
F
K
E
G
K
E
R
M
Y
----
Q
D
R
R
N
L
T
K
L
S
L
I
F
S
H
M
L
A
E
I
K
A
I
F
P
N
G
Q
F
Q
G
D
N
F
R
I
T
K
A
D
A
A
E
F
W
R
K
F
F
G
D
K
T
I
V
P
W
K
V
F
R
Q
C
L
H
E
V
H
Q
I
S
S
G
L
E
A
M
A
L
K
S
T
I
D
L
T
C
N
D
Y
I
S
V
F
E
F
D
I
F
T
R
L
F
Q
P
W
G
S
I
L
R
N
W
N
F
L
A
V
T
H
P
G
Y
M
A
F
L
T
Y
D
E
V
K
A
R
L
Q
K
Y
S
T
K
P
G
S
Y
I
F
R
L
S
C
T
R
L
G
Q
W
A
I
G
Y
V
T
G
D
G
N
I
L
Q
T
I
P
H
N
K
P
L
F
Q
A
L
I
D
G
S
R
E
G
F
Y
L
Y
P
D
G
R
S
Y
N
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
77.03
97%
-52
- C1 -
-
3BUW
-
CBL_HUMAN
B:
[25-329]
---------------------------------------------
P
P
G
T
V
D
K
K
M
V
E
K
C
W
K
L
M
D
K
V
V
R
L
C
Q
N
P
K
L
A
L
K
N
S
P
P
Y
I
L
D
L
L
P
D
T
Y
Q
H
L
R
T
I
L
S
R
Y
E
G
K
M
E
T
L
G
E
N
E
Y
F
R
V
F
M
E
N
L
M
K
K
T
K
Q
T
I
S
L
F
K
E
G
K
E
R
M
Y
E
E
N
S
Q
P
R
R
N
L
T
K
L
S
L
I
F
S
H
M
L
A
E
L
K
G
I
F
P
S
G
L
F
Q
G
D
T
F
R
I
T
K
A
D
A
A
E
F
W
R
K
A
F
G
E
K
T
I
V
P
W
K
S
F
R
Q
A
L
H
E
V
H
P
I
S
S
G
L
E
A
M
A
L
K
S
T
I
D
L
T
C
N
D
Y
I
S
V
F
E
F
D
I
F
T
R
L
F
Q
P
W
S
S
L
L
R
N
W
N
S
L
A
V
T
H
P
G
Y
M
A
F
L
T
Y
D
E
V
K
A
R
L
Q
K
F
I
H
K
P
G
S
Y
I
F
R
L
S
C
T
R
L
G
Q
W
A
I
G
Y
V
T
A
D
G
N
I
L
Q
T
I
P
H
N
K
P
L
F
Q
A
L
I
D
G
F
R
E
G
F
Y
L
F
P
D
G
R
N
Q
N
P
D
L
T
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
76.64
97%
-50
- C1 -
-
3BUN
-
CBL_HUMAN
B:
[26-329]
----------------------------------------------
P
G
T
V
D
K
K
M
V
E
K
C
W
K
L
M
D
K
V
V
R
L
C
Q
N
P
K
L
A
L
K
N
S
P
P
Y
I
L
D
L
L
P
D
T
Y
Q
H
L
R
T
I
L
S
R
Y
E
G
K
M
E
T
L
G
E
N
E
Y
F
R
V
F
M
E
N
L
M
K
K
T
K
Q
T
I
S
L
F
K
E
G
K
E
R
M
Y
E
E
N
S
Q
P
R
R
N
L
T
K
L
S
L
I
F
S
H
M
L
A
E
L
K
G
I
F
P
S
G
L
F
Q
G
D
T
F
R
I
T
K
A
D
A
A
E
F
W
R
K
A
F
G
E
K
T
I
V
P
W
K
S
F
R
Q
A
L
H
E
V
H
P
I
S
S
G
L
E
A
M
A
L
K
S
T
I
D
L
T
C
N
D
Y
I
S
V
F
E
F
D
I
F
T
R
L
F
Q
P
W
S
S
L
L
R
N
W
N
S
L
A
V
T
H
P
G
Y
M
A
F
L
T
Y
D
E
V
K
A
R
L
Q
K
F
I
H
K
P
G
S
Y
I
F
R
L
S
C
T
R
L
G
Q
W
A
I
G
Y
V
T
A
D
G
N
I
L
Q
T
I
P
H
N
K
P
L
F
Q
A
L
I
D
G
F
R
E
G
F
Y
L
F
P
D
G
R
N
Q
N
P
D
L
T
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
76.63
97%
-59
- C1 -
-
3BUO
-
CBL_HUMAN
B:
[26-329]
----------------------------------------------
P
G
T
V
D
K
K
M
V
E
K
C
W
K
L
M
D
K
V
V
R
L
C
Q
N
P
K
L
A
L
K
N
S
P
P
Y
I
L
D
L
L
P
D
T
Y
Q
H
L
R
T
I
L
S
R
Y
E
G
K
M
E
T
L
G
E
N
E
Y
F
R
V
F
M
E
N
L
M
K
K
T
K
Q
T
I
S
L
F
K
E
G
K
E
R
M
Y
E
E
N
S
Q
P
R
R
N
L
T
K
L
S
L
I
F
S
H
M
L
A
E
L
K
G
I
F
P
S
G
L
F
Q
G
D
T
F
R
I
T
K
A
D
A
A
E
F
W
R
K
A
F
G
E
K
T
I
V
P
W
K
S
F
R
Q
A
L
H
E
V
H
P
I
S
S
G
L
E
A
M
A
L
K
S
T
I
D
L
T
C
N
D
Y
I
S
V
F
E
F
D
I
F
T
R
L
F
Q
P
W
S
S
L
L
R
N
W
N
S
L
A
V
T
H
P
G
Y
M
A
F
L
T
Y
D
E
V
K
A
R
L
Q
K
F
I
H
K
P
G
S
Y
I
F
R
L
S
C
T
R
L
G
Q
W
A
I
G
Y
V
T
A
D
G
N
I
L
Q
T
I
P
H
N
K
P
L
F
Q
A
L
I
D
G
F
R
E
G
F
Y
L
F
P
D
G
R
N
Q
N
P
D
L
T
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
76.62
97%
-49
- C1 -
-
3BUX
-
CBL_HUMAN
B:
[25-329]
---------------------------------------------
P
P
G
T
V
D
K
K
M
V
E
K
C
W
K
L
M
D
K
V
V
R
L
C
Q
N
P
K
L
A
L
K
N
S
P
P
Y
I
L
D
L
L
P
D
T
Y
Q
H
L
R
T
I
L
S
R
Y
E
G
K
M
E
T
L
G
E
N
E
Y
F
R
V
F
M
E
N
L
M
K
K
T
K
Q
T
I
S
L
F
K
E
G
K
E
R
M
Y
E
E
N
S
Q
P
R
R
N
L
T
K
L
S
L
I
F
S
H
M
L
A
E
L
K
G
I
F
P
S
G
L
F
Q
G
D
T
F
R
I
T
K
A
D
A
A
E
F
W
R
K
A
F
G
E
K
T
I
V
P
W
K
S
F
R
Q
A
L
H
E
V
H
P
I
S
S
G
L
E
A
M
A
L
K
S
T
I
D
L
T
C
N
D
Y
I
S
V
F
E
F
D
I
F
T
R
L
F
Q
P
W
S
S
L
L
R
N
W
N
S
L
A
V
T
H
P
G
Y
M
A
F
L
T
Y
D
E
V
K
A
R
L
Q
K
F
I
H
K
P
G
S
Y
I
F
R
L
S
C
T
R
L
G
Q
W
A
I
G
Y
V
T
A
D
G
N
I
L
Q
T
I
P
H
N
K
P
L
F
Q
A
L
I
D
G
F
R
E
G
F
Y
L
F
P
D
G
R
N
Q
N
P
D
L
T
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------