@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LIS1_MOUSE: (2018-07-13 )
MVLSQRQRDELNRAIADYLRSNGYEEAYSVFKKEAELDMNEELDKKYAGLLEKKWTSVIRLQKKVMELESKLNEAKEEFTSGGPLGQKRDPKEWIPRPPEKYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.....-..-120.......130.......140........150.......-160.......170.......180.----.------...-..190.......200.-------.-.....210.......220.......230.......240..--.....250.......260.......-270.......280.......290..---------------------------------------.-----------------------....300.......310.......320.......330..--------.--....340.....---..350.......360.......370.......380.......390.......400.........410
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MVL
S
Q
R
Q
R
D
E
L
N
R
A
I
A
D
Y
L
R
SNG
Y
E
E
A
Y
S
V
F
K
K
E
A
ELD
M
N
E
E
L
D
K
K
Y
A
G
L
L
E
K
K
W
T
S
V
I
R
L
Q
K
K
V
M
E
L
E
S
K
L
N
E
A
K
E
E
FTSGGPLGQKR
D
P
K
EWIPRP
P
E
KYALSGHRS
P
V
T
R
V
I
F
H
-
P
V
-
F
S
V
M
VSASED
A
T
I
K
V
W
DYETG
D
-
F
E
R
T
LKGHTDSV
Q
D
I
SFD-HSG
K
L
L
ASCSA
D
M
T
I
K
L
WDFQG
F
E
----
C
------
I
R
T
-MHGHDHNV
S
S
V
A
I
MPN-------G-
D
H
I
V
SASRD
K
T
I
K
M
W
E
VQT
G
Y
C
VKTFTG
H
R
E
W
V
R
M
VRPNQ--D
G
T
L
I
A
SCSND
Q
T
V
R
V
W
V
V
A
T
K
E
C
K
-
A
E
L
R
E
H
E
H
V
V
E
C
I
SWAPESSYS
S
I
S
---------------------------------------E-----------------------ATGSETKKSGKPG
P
F
L
LSGSRD
K
T
I
K
M
W
DVST
G
M
C
L
M
T
L--------V--GHDN
W
V
R
G
V
L
FH---SG
G
K
F
I
L
S
CADD
K
T
L
R
V
W
DYKN
K
R
C
M
K
T
L
N
A
H
E
H
F
V
T
SLDFHKTA
P
Y
V
V
TGSV--D
Q
T
V
K
V
W
ECR
1
PsiBlast_PDB
92.22
99%
-91
- C1 -
-
1VYH
-
LIS1_MOUSE
C:
[92-408]
-------------------------------------------------------------------------------------------
K
E
W
I
P
R
P
P
E
K
Y
A
L
S
G
H
R
S
P
V
T
R
V
I
F
H
-
P
V
-
F
S
V
M
V
S
A
S
E
D
A
T
I
K
V
W
D
Y
E
T
G
D
-
F
E
R
T
L
K
G
H
T
D
S
V
Q
D
I
S
F
D
-
H
S
G
K
L
L
A
S
C
S
A
D
M
T
I
K
L
W
D
F
Q
G
F
E
----
C
------
I
R
T
-
M
H
G
H
D
H
N
V
S
S
V
S
I
M
P
N
-------
G
-
D
H
I
V
S
A
S
R
D
K
T
I
K
M
W
E
V
Q
T
G
Y
C
V
K
T
F
T
G
H
R
E
W
V
R
M
V
R
P
N
Q
--
D
G
T
L
I
A
S
C
S
N
D
Q
T
V
R
V
W
V
V
A
T
K
E
C
K
-
A
E
L
R
E
H
R
H
V
V
E
C
I
S
W
A
P
E
S
S
Y
S
S
I
S
---------------------------------------
E
-----------------------
A
T
G
S
E
-------
G
P
F
L
L
S
G
S
R
D
K
T
I
K
M
W
D
V
S
T
G
M
C
L
M
T
L
--------
V
--
G
H
D
N
W
V
R
G
V
L
F
H
---
S
G
G
K
F
I
L
S
C
A
D
D
K
T
L
R
V
W
D
Y
K
N
K
R
C
M
K
T
L
N
A
H
E
H
F
V
T
S
L
D
F
H
K
T
A
P
Y
V
V
T
G
S
V
--
D
Q
T
V
K
V
W
E
--
30
HHSearch
77.21
29%
-96
- C1 -
-
4YVD
-
PLRG1_HUMAN
A:
[58-352]
-----------------------------------------------------------------------------------------------------
R
V
I
S
G
H
L
G
W
V
R
C
I
A
V
E
-
P
G
-
N
Q
W
F
V
T
G
S
A
D
R
T
I
K
I
W
D
L
A
S
G
K
-
L
K
L
S
L
T
G
H
I
S
T
V
R
G
V
I
V
S
-
T
R
S
P
Y
L
F
S
C
G
E
D
K
Q
V
K
C
W
D
L
E
Y
N
K
----
V
------
I
R
H
-
Y
H
G
H
L
S
A
V
Y
G
L
D
L
H
P
T
-------
I
-
D
V
L
V
T
C
S
R
D
S
T
A
R
I
W
D
V
R
T
K
A
S
V
H
T
L
S
G
H
T
N
A
V
A
T
V
R
C
Q
A
--
A
E
P
Q
I
I
T
G
S
H
D
T
T
I
R
L
W
D
L
V
A
G
K
T
R
-
V
T
L
T
N
H
K
K
S
V
R
A
V
V
L
H
P
R
----------------------------------------------------------------------------------
H
Y
T
F
A
S
G
-
S
P
D
N
I
K
Q
W
K
F
P
D
G
S
F
I
Q
N
L
--------
S
--
G
H
N
A
I
I
N
T
L
T
V
N
---
S
D
G
-
V
L
V
S
G
A
D
N
G
T
M
H
L
W
D
W
R
T
G
Y
N
F
Q
R
V
H
A
-
E
S
G
I
F
A
C
A
F
D
Q
S
E
S
R
L
L
T
A
E
A
--
D
K
T
I
K
V
Y
R
E
D
34
HHSearch
68.51
26%
-28
- C1 -
-
5KDO
-
GBB1_BOVIN (first)
B:
[49-340]
-----------------------------------------------------------------------------------------------------
R
T
L
R
G
H
L
A
K
I
Y
A
M
H
W
G
-
T
D
-
S
R
L
L
V
S
A
S
Q
D
G
K
L
I
I
W
D
S
Y
T
T
N
-
K
V
H
A
I
P
L
R
S
S
W
V
M
T
C
A
Y
A
-
P
S
G
N
Y
V
A
C
G
G
L
D
N
I
C
S
I
Y
N
L
K
T
--VR--
V
------
S
R
E
-
L
A
G
H
T
G
Y
L
S
C
C
R
F
L
D
D
-------
N
--
Q
I
V
T
S
S
G
D
T
T
C
A
L
W
D
I
E
T
G
Q
Q
T
T
T
F
T
G
H
T
G
D
V
M
S
L
S
L
A
P
--
D
T
R
L
F
V
S
G
A
C
D
A
S
A
K
L
W
D
V
R
E
G
M
C
R
-
Q
T
F
T
G
H
E
S
D
I
N
A
I
C
F
F
P
N
----------------------------------------------------------------------------------
G
N
A
F
A
T
G
S
D
D
A
T
C
R
L
F
D
L
R
A
D
Q
E
L
M
T
Y
--------
S
H
D
N
I
I
C
G
I
T
S
V
S
F
S
---
K
S
G
R
L
L
L
A
G
Y
D
D
F
N
C
N
V
W
D
A
L
K
A
D
R
A
G
V
L
A
G
H
D
N
R
V
S
C
L
G
V
T
D
D
G
M
A
V
A
T
G
S
W
--
D
S
F
L
K
I
W
N
--
26
HHSearch
66.23
24%
-38
- C1 -
-
2PBI
4
GNB5_MOUSE
D:
[58-354]
-----------------------------------------------------------------------------------------------------
R
T
L
K
G
H
G
N
K
V
L
C
M
D
W
C
-
K
D
-
K
R
R
I
V
S
S
S
Q
D
G
K
V
I
V
W
D
S
F
T
T
N
-
K
E
H
A
V
T
M
P
C
T
W
V
M
A
C
A
Y
A
-
P
S
G
C
A
I
A
C
G
G
L
D
N
K
C
S
V
Y
P
L
T
F
D
K
----
N
ENMAAK
K
K
S
-
V
A
M
H
T
N
Y
L
S
A
C
S
F
T
N
S
-------
D
-
M
Q
I
L
T
A
S
G
D
G
T
C
A
L
W
D
V
E
S
G
Q
L
L
Q
S
F
H
G
H
G
A
D
V
L
C
L
D
L
A
P
SE
T
G
N
T
F
V
S
G
G
C
D
K
K
A
M
V
W
D
M
R
S
G
Q
C
V
-
Q
A
F
E
T
H
E
S
D
V
N
S
V
R
Y
Y
P
S
----------------------------------------------------------------------------------
G
D
A
F
A
S
G
S
D
D
A
T
C
R
L
Y
D
L
R
A
D
R
E
V
A
I
Y
--------
S
KE
S
I
I
F
G
A
S
S
V
D
F
S
---
L
S
G
R
L
L
F
A
G
Y
N
D
Y
T
I
N
V
W
D
V
L
K
G
S
R
V
S
I
L
F
G
H
E
N
R
V
S
T
L
R
V
S
P
D
G
T
A
F
C
S
G
S
W
--
D
H
T
L
R
V
W
A
--
23
HHSearch
64.78
24%
-41
- C1 -
-
2PBI
3
GNB5_MOUSE
B:
[58-354]
-----------------------------------------------------------------------------------------------------
R
T
L
K
G
H
G
N
K
V
L
C
M
D
W
C
-
K
D
-
K
R
R
I
V
S
S
S
Q
D
G
K
V
I
V
W
D
S
F
T
T
N
-
K
E
H
A
V
T
M
P
C
T
W
V
M
A
C
A
Y
A
-
P
S
G
C
A
I
A
C
G
G
L
D
N
K
C
S
V
Y
P
L
T
F
D
K
----
N
ENMAAK
K
K
S
-
V
A
M
H
T
N
Y
L
S
A
C
S
F
T
N
S
-------
D
-
M
Q
I
L
T
A
S
G
D
G
T
C
A
L
W
D
V
E
S
G
Q
L
L
Q
S
F
H
G
H
G
A
D
V
L
C
L
D
L
A
P
SE
T
G
N
T
F
V
S
G
G
C
D
K
K
A
M
V
W
D
M
R
S
G
Q
C
V
-
Q
A
F
E
T
H
E
S
D
V
N
S
V
R
Y
Y
P
S
----------------------------------------------------------------------------------
G
D
A
F
A
S
G
S
D
D
A
T
C
R
L
Y
D
L
R
A
D
R
E
V
A
I
Y
S
K
------
E
--
S
I
I
F
G
A
S
S
V
D
F
S
---
L
S
G
R
L
L
F
A
G
Y
N
D
Y
T
I
N
V
W
D
V
L
K
G
S
R
V
S
I
L
F
G
H
E
N
R
V
S
T
L
R
V
S
P
D
G
T
A
F
C
S
G
S
W
--
D
H
T
L
R
V
W
A
--
36
HHSearch
62.12
26%
-15
* C1 *
-
1TBG
-
GBB1_BOVIN
B:
[49-340]
-----------------------------------------------------------------------------------------------------
R
T
L
R
G
H
L
A
K
I
Y
A
M
H
W
G
-
T
D
-
S
R
L
L
V
S
A
S
Q
D
G
K
L
I
I
W
D
S
Y
T
T
N
-
K
V
H
A
I
P
L
R
S
S
W
V
M
T
C
A
Y
A
-
P
S
G
N
Y
V
A
C
G
G
L
D
N
I
C
S
I
Y
N
L
K
T
R
E
GNVR
V
------
S
R
E
-
L
A
G
H
T
G
Y
L
S
C
C
R
F
L
D
D
-------
N
--
Q
I
V
T
S
S
G
D
T
T
C
A
L
W
D
I
E
T
G
Q
Q
T
T
T
F
T
G
H
T
G
D
V
M
S
L
S
L
A
P
--
D
T
R
L
F
V
S
G
A
C
D
A
S
A
K
L
W
D
V
R
E
G
M
C
R
-
Q
T
F
T
G
H
E
S
D
I
N
A
I
C
F
F
P
N
----------------------------------------------------------------------------------
G
N
A
F
A
T
G
S
D
D
A
T
C
R
L
F
D
L
R
A
D
Q
E
L
M
T
Y
--------
S
HD
N
I
I
C
G
I
T
S
V
S
F
S
---
K
S
G
R
L
L
L
A
G
Y
D
D
F
N
C
N
V
W
D
A
L
K
A
D
R
A
G
V
L
A
G
H
D
N
R
V
S
C
L
G
V
T
D
D
G
M
A
V
A
T
G
S
W
--
D
S
F
L
K
I
W
N
--
37
HHSearch
61.39
33%
2
- C1 -
-
5MZH
-
DAW1_CHLRE
B:
[131-418]
------------------------------------------------------------------------------------------------------
T
L
E
G
H
K
N
V
V
Y
A
I
A
F
N
N
P
Y
-
G
D
K
I
V
T
G
S
F
D
K
T
C
K
L
W
D
A
Y
T
G
Q
-
L
Y
Y
T
L
K
G
H
Q
T
E
I
V
C
L
S
F
N
-
P
Q
S
T
I
I
A
T
G
S
M
D
N
T
A
K
L
W
D
V
E
T
G
Q
----
E
------
R
A
T
-
L
A
G
H
R
A
E
I
V
S
L
G
F
N
T
G
-------
G
-
D
L
I
V
T
G
S
F
D
H
D
S
R
L
W
D
V
R
T
G
Q
C
V
H
V
L
S
G
H
R
G
E
V
S
S
T
Q
F
N
Y
--
A
G
T
L
V
V
S
G
S
I
D
C
T
S
R
L
W
D
V
R
S
G
R
C
L
-
S
V
K
Q
G
H
T
D
E
V
L
D
V
A
F
D
A
A
----------------------------------------------------------------------------------
G
T
K
M
V
S
A
S
A
D
G
S
A
R
L
Y
H
T
L
T
G
V
C
Q
H
T
L
--------
V
--
G
H
E
G
E
I
S
K
V
A
F
N
---
P
Q
G
T
R
L
I
T
A
S
S
D
K
T
C
R
L
W
D
C
D
T
G
E
C
L
Q
V
L
E
G
H
T
D
E
I
F
S
C
A
F
N
Y
E
G
D
F
I
I
T
G
S
K
--
D
N
T
C
R
I
W
K
A
-
6
PsiBlast_PDB
60.83
31%
-52
- C1 -
-
2H9L
-
WDR5_HUMAN
A:
[18-326]
-------------------------------------------------------------------------------------
G
T
Q
S
K
P
T
P
V
K
P
N
Y
A
L
K
F
T
L
A
G
H
T
K
A
V
S
S
V
K
F
S
-
P
N
-
G
E
W
L
A
S
S
S
A
D
K
L
I
K
I
W
G
A
Y
D
G
K
-
F
E
K
T
I
S
G
H
K
L
G
I
S
D
V
A
W
S
-
S
D
S
N
L
L
V
S
A
S
D
D
K
T
L
K
I
W
D
V
S
S
G
K
----
C
------
L
K
T
-
L
K
G
H
S
N
Y
V
F
C
C
N
F
N
P
Q
-------
S
-
N
L
I
V
S
G
S
F
D
E
S
V
R
I
W
D
V
K
T
G
K
C
L
K
T
L
P
A
H
S
D
P
V
S
A
V
H
F
N
R
--
D
G
S
L
I
V
S
S
S
Y
D
G
L
C
R
I
W
D
T
A
S
G
Q
C
L
-
K
T
L
I
D
D
D
N
--------
P
P
V
S
F
V
K
F
S
---------------------------------------
P
-----------------------
N
-----------
G
K
Y
I
L
A
A
T
L
D
N
T
L
K
L
W
D
Y
S
K
G
K
C
L
K
T
Y
--------
T
--
G
H
K
N
E
K
Y
C
I
F
A
N
F
S
V
T
G
G
K
W
I
V
S
G
S
E
D
N
L
V
Y
I
W
N
L
Q
T
K
E
I
V
Q
K
L
Q
G
H
T
D
V
V
I
S
T
A
C
H
P
T
E
N
I
I
A
S
A
A
L
EN
D
K
T
I
K
L
W
K
--
16
PsiBlast_PDB
60.62
31%
-53
- C1 -
-
5EAP
7
WDR5_HUMAN
A:
[1-309]
-------------------------------------------------------------------------------------
G
T
Q
S
K
P
T
P
V
K
P
N
Y
A
L
K
F
T
L
A
G
H
T
K
A
V
S
S
V
K
F
S
-
P
N
-
G
E
W
L
A
S
S
S
A
D
K
L
I
K
I
W
G
A
Y
D
G
K
-
F
E
K
T
I
S
G
H
K
L
G
I
S
D
V
A
W
S
-
S
D
S
N
L
L
V
S
A
S
D
D
K
T
L
K
I
W
D
V
S
S
G
K
----
C
------
L
K
T
-
L
K
G
H
S
N
Y
V
F
C
C
N
F
N
P
Q
-------
S
-
N
L
I
V
S
G
S
F
D
E
S
V
R
I
W
D
V
K
T
G
K
C
L
K
T
L
P
A
H
S
D
P
V
S
A
V
H
F
N
R
--
D
G
S
L
I
V
S
S
S
Y
D
G
L
C
R
I
W
D
T
A
S
G
Q
C
L
-
K
T
L
I
D
--
N
--------
P
P
V
S
F
V
K
F
S
---------------------------------------
P
-----------------------
N
-----------
G
K
Y
I
L
A
A
T
L
D
N
T
L
K
L
W
D
Y
S
K
G
K
C
L
K
T
Y
--------
T
--
G
H
K
N
E
K
Y
C
I
F
A
N
F
S
V
T
G
G
K
W
I
V
S
G
S
E
D
N
L
V
Y
I
W
N
L
Q
T
K
E
I
V
Q
K
L
Q
G
H
T
D
V
V
I
S
T
A
C
H
P
T
E
N
I
I
A
S
A
A
L
EN
D
K
T
I
K
L
W
K
--
21
HHSearch
60.53
30%
-1
- C1 -
-
4WJV
-
NLE1_YEAST
C:
[5-381]
-------------------------------------------------------------------------------------------------------
I
A
G
H
G
S
T
I
L
C
S
A
F
A
-
P
H
T
S
S
R
M
V
T
G
A
G
D
N
T
A
R
I
W
D
C
D
T
Q
T
-
P
M
H
T
L
K
G
H
Y
N
W
V
L
C
V
S
W
S
-
P
D
G
E
V
I
A
T
G
S
M
D
N
T
I
R
L
W
D
P
K
S
G
Q
----
C
------
L
G
D
A
L
R
G
H
S
K
W
I
T
S
L
S
W
E
P
I
HLVKPGS
K
-
P
R
L
A
S
S
S
K
D
G
T
I
K
I
W
D
T
V
S
R
V
C
Q
Y
T
M
S
G
H
T
N
S
V
S
C
V
K
W
G
G
--
Q
-
G
L
L
Y
S
G
S
H
D
R
T
V
R
V
W
D
I
N
S
Q
G
R
C
I
N
I
L
K
S
H
A
H
W
V
N
H
L
S
L
S
T
D
Y
A
L
R
I
G
A
FDHTGKKPSTPEEAQKKALENYEKICKKNGNSEEMMVTA
S
DDYTMFLWNPLKSTKPIARMTGH
Q
K
L
V
N
H
V
A
F
S
P
D
G
R
Y
I
V
S
A
S
F
D
N
S
I
K
L
W
D
G
R
D
G
K
F
I
S
T
F
--------
R
--
G
H
V
A
S
V
Y
Q
V
A
W
S
---
S
D
C
R
L
L
V
S
C
S
K
D
T
T
L
K
V
W
D
V
R
T
R
K
L
S
V
D
L
P
G
H
K
D
E
V
Y
T
V
D
W
S
V
D
G
K
R
V
C
S
G
G
K
--
D
K
M
V
R
L
W
T
H
-
12
PsiBlast_PDB
59.97
31%
-53
- C1 -
-
4QQE
4
WDR5_RAT
A:
[9-309]
---------------------------------------------------------------------------------------------
V
K
P
N
Y
A
L
K
F
T
L
A
G
H
T
K
A
V
S
S
V
K
F
S
-
P
N
-
G
E
W
L
A
S
S
S
A
D
K
L
I
K
I
W
G
A
Y
D
G
K
-
F
E
K
T
I
S
G
H
K
L
G
I
S
D
V
A
W
S
-
S
D
S
N
L
L
V
S
A
S
D
D
K
T
L
K
I
W
D
V
S
S
G
K
----
C
------
L
K
T
-
L
K
G
H
S
N
Y
V
F
C
C
N
F
N
P
Q
-------
S
-
N
L
I
V
S
G
S
F
D
E
S
V
R
I
W
D
V
K
T
G
K
C
L
K
T
L
P
A
H
S
D
P
V
S
A
V
H
F
N
R
--
D
G
S
L
I
V
S
S
S
Y
D
G
L
C
R
I
W
D
T
A
S
G
Q
C
L
-
K
T
L
I
D
D
D
N
--------
P
P
V
S
F
V
K
F
S
---------------------------------------
P
-----------------------
N
-----------
G
K
Y
I
L
A
A
T
L
D
N
T
L
K
L
W
D
Y
S
K
G
K
C
L
K
T
Y
--------
T
--
G
H
K
N
E
K
Y
C
I
F
A
N
F
S
V
T
G
G
K
W
I
V
S
G
S
E
D
N
L
V
Y
I
W
N
L
Q
T
K
E
I
V
Q
K
L
Q
G
H
T
D
V
V
I
S
T
A
C
H
P
T
E
N
I
I
A
S
A
A
L
EN
D
K
T
I
K
L
W
K
--
4
PsiBlast_PDB
59.53
31%
-53
- C1 -
-
5M23
1
WDR5_HUMAN
A:
[133-431]
-----------------------------------------------------------------------------------------------
P
N
Y
A
L
K
F
T
L
A
G
H
T
K
A
V
S
S
V
K
F
S
-
P
N
-
G
E
W
L
A
S
S
S
A
D
K
L
I
K
I
W
G
A
Y
D
G
K
-
F
E
K
T
I
S
G
H
K
L
G
I
S
D
V
A
W
S
-
S
D
S
N
L
L
V
S
A
S
D
D
K
T
L
K
I
W
D
V
S
S
G
K
----
C
------
L
K
T
-
L
K
G
H
S
N
Y
V
F
C
C
N
F
N
P
Q
-------
S
-
N
L
I
V
S
G
S
F
D
E
S
V
R
I
W
D
V
K
T
G
K
C
L
K
T
L
P
A
H
S
D
P
V
S
A
V
H
F
N
R
--
D
G
S
L
I
V
S
S
S
Y
D
G
L
C
R
I
W
D
T
A
S
G
Q
C
L
-
K
T
L
I
D
D
D
N
--------
P
P
V
S
F
V
K
F
S
---------------------------------------
P
-----------------------
N
-----------
G
K
Y
I
L
A
A
T
L
D
N
T
L
K
L
W
D
Y
S
K
G
K
C
L
K
T
Y
--------
T
--
G
H
K
N
E
K
Y
C
I
F
A
N
F
S
V
T
G
G
K
W
I
V
S
G
S
E
D
N
L
V
Y
I
W
N
L
Q
T
K
E
I
V
Q
K
L
Q
G
H
T
D
V
V
I
S
T
A
C
H
P
T
E
N
I
I
A
S
A
A
L
EN
D
K
T
I
K
L
W
K
--
27
HHSearch
59.52
32%
-9
- C1 -
-
5MZH
-
DAW1_CHLRE
A:
[89-376]
------------------------------------------------------------------------------------------------------
V
L
R
A
H
I
L
P
L
T
N
C
A
F
N
-
K
S
-
G
D
R
F
I
T
G
S
Y
D
R
T
C
K
V
W
N
T
F
T
G
E
-
E
V
F
T
L
E
G
H
K
N
V
V
Y
A
I
A
F
N
N
P
Y
G
D
K
I
V
T
G
S
F
D
K
T
C
K
L
W
D
A
Y
T
G
Q
----
L
------
Y
Y
T
-
L
K
G
H
Q
T
E
I
V
C
L
S
F
N
P
Q
-------
S
-
T
I
I
A
T
G
S
M
D
N
T
A
K
L
W
D
V
E
T
G
Q
E
R
A
T
L
A
G
H
R
A
E
I
V
S
L
G
F
N
T
--
G
G
D
L
I
V
T
G
S
F
D
H
D
S
R
L
W
D
V
R
T
G
Q
C
V
-
H
V
L
S
G
H
R
G
E
V
S
S
T
Q
F
N
Y
A
----------------------------------------------------------------------------------
G
T
L
V
V
S
G
S
I
D
C
T
S
R
L
W
D
V
R
S
G
R
C
L
S
V
K
--------
Q
--
G
H
T
D
E
V
L
D
V
A
F
D
---
A
A
G
T
K
M
V
S
A
S
A
D
G
S
A
R
L
Y
H
T
L
T
G
V
C
Q
H
T
L
V
G
H
E
G
E
I
S
K
V
A
F
N
P
Q
G
T
R
L
I
T
A
S
S
--
D
K
T
C
R
L
W
D
C
-
39
HHSearch
59.51
33%
6
- C1 -
-
5MZH
-
DAW1_CHLRE
A:
[131-418]
------------------------------------------------------------------------------------------------------
T
L
E
G
H
K
N
V
V
Y
A
I
A
F
N
N
P
Y
-
G
D
K
I
V
T
G
S
F
D
K
T
C
K
L
W
D
A
Y
T
G
Q
-
L
Y
Y
T
L
K
G
H
Q
T
E
I
V
C
L
S
F
N
-
P
Q
S
T
I
I
A
T
G
S
M
D
N
T
A
K
L
W
D
V
E
T
G
Q
----
E
------
R
A
T
-
L
A
G
H
R
A
E
I
V
S
L
G
F
N
T
G
-------
G
-
D
L
I
V
T
G
S
F
D
H
D
S
R
L
W
D
V
R
T
G
Q
C
V
H
V
L
S
G
H
R
G
E
V
S
S
T
Q
F
N
Y
--
A
G
T
L
V
V
S
G
S
I
D
C
T
S
R
L
W
D
V
R
S
G
R
C
L
-
S
V
K
Q
G
H
T
D
E
V
L
D
V
A
F
D
A
A
----------------------------------------------------------------------------------
G
T
K
M
V
S
A
S
A
D
G
S
A
R
L
Y
H
T
L
T
G
V
C
Q
H
T
L
--------
V
--
G
H
E
G
E
I
S
K
V
A
F
N
---
P
Q
G
T
R
L
I
T
A
S
S
D
K
T
C
R
L
W
D
C
D
T
G
E
C
L
Q
V
L
E
G
H
T
D
E
I
F
S
C
A
F
N
Y
E
G
D
F
I
I
T
G
S
K
--
D
N
T
C
R
I
W
K
A
-
10
PsiBlast_PDB
59.51
31%
-55
- C1 -
-
4IA9
3
WDR5_HUMAN
A:
[8-309]
--------------------------------------------------------------------------------------------
P
V
K
P
N
Y
A
L
K
F
T
L
A
G
H
T
K
A
V
S
S
V
K
F
S
-
P
N
-
G
E
W
L
A
S
S
S
A
D
K
L
I
K
I
W
G
A
Y
D
G
K
-
F
E
K
T
I
S
G
H
K
L
G
I
S
D
V
A
W
S
-
S
D
S
N
L
L
V
S
A
S
D
D
K
T
L
K
I
W
D
V
S
S
G
K
----
C
------
L
K
T
-
L
K
G
H
S
N
Y
V
F
C
C
N
F
N
P
Q
-------
S
-
N
L
I
V
S
G
S
F
D
E
S
V
R
I
W
D
V
K
T
G
K
C
L
K
T
L
P
A
H
S
D
P
V
S
A
V
H
F
N
R
--
D
G
S
L
I
V
S
S
S
Y
D
G
L
C
R
I
W
D
T
A
S
G
Q
C
L
-
K
T
L
I
D
D
D
N
--------
P
P
V
S
F
V
K
F
S
---------------------------------------
P
-----------------------
N
-----------
G
K
Y
I
L
A
A
T
L
D
N
T
L
K
L
W
D
Y
S
K
G
K
C
L
K
T
Y
--------
T
--
G
H
K
N
E
K
Y
C
I
F
A
N
F
S
V
T
G
G
K
W
I
V
S
G
S
E
D
N
L
V
Y
I
W
N
L
Q
T
K
E
I
V
Q
K
L
Q
G
H
T
D
V
V
I
S
T
A
C
H
P
T
E
N
I
I
A
S
A
A
L
EN
D
K
T
I
K
L
W
K
--
28
HHSearch
59.45
32%
-13
- C1 -
-
5MZH
-
DAW1_CHLRE
B:
[89-376]
------------------------------------------------------------------------------------------------------
V
L
R
A
H
I
L
P
L
T
N
C
A
F
N
-
K
S
-
G
D
R
F
I
T
G
S
Y
D
R
T
C
K
V
W
N
T
F
T
G
E
-
E
V
F
T
L
E
G
H
K
N
V
V
Y
A
I
A
F
N
N
P
Y
G
D
K
I
V
T
G
S
F
D
K
T
C
K
L
W
D
A
Y
T
G
Q
----
L
------
Y
Y
T
-
L
K
G
H
Q
T
E
I
V
C
L
S
F
N
P
Q
-------
S
-
T
I
I
A
T
G
S
M
D
N
T
A
K
L
W
D
V
E
T
G
Q
E
R
A
T
L
A
G
H
R
A
E
I
V
S
L
G
F
N
T
--
G
G
D
L
I
V
T
G
S
F
D
H
D
S
R
L
W
D
V
R
T
G
Q
C
V
-
H
V
L
S
G
H
R
G
E
V
S
S
T
Q
F
N
Y
A
----------------------------------------------------------------------------------
G
T
L
V
V
S
G
S
I
D
C
T
S
R
L
W
D
V
R
S
G
R
C
L
S
V
K
--------
Q
--
G
H
T
D
E
V
L
D
V
A
F
D
---
A
A
G
T
K
M
V
S
A
S
A
D
G
S
A
R
L
Y
H
T
L
T
G
V
C
Q
H
T
L
V
G
H
E
G
E
I
S
K
V
A
F
N
P
Q
G
T
R
L
I
T
A
S
S
--
D
K
T
C
R
L
W
D
C
-
13
PsiBlast_PDB
59.45
31%
-54
- C1 -
-
4QL1
1
WDR5_HUMAN
A:
[9-309]
---------------------------------------------------------------------------------------------
V
K
P
N
Y
A
L
K
F
T
L
A
G
H
T
K
A
V
S
S
V
K
F
S
-
P
N
-
G
E
W
L
A
S
S
S
A
D
K
L
I
K
I
W
G
A
Y
D
G
K
-
F
E
K
T
I
S
G
H
K
L
G
I
S
D
V
A
W
S
-
S
D
S
N
L
L
V
S
A
S
D
D
K
T
L
K
I
W
D
V
S
S
G
K
----
C
------
L
K
T
-
L
K
G
H
S
N
Y
V
F
C
C
N
F
N
P
Q
-------
S
-
N
L
I
V
S
G
S
F
D
E
S
V
R
I
W
D
V
K
T
G
K
C
L
K
T
L
P
A
H
S
D
P
V
S
A
V
H
F
N
R
--
D
G
S
L
I
V
S
S
S
Y
D
G
L
C
R
I
W
D
T
A
S
G
Q
C
L
-
K
T
L
I
D
D
D
N
--------
P
P
V
S
F
V
K
F
S
---------------------------------------
P
-----------------------
N
-----------
G
K
Y
I
L
A
A
T
L
D
N
T
L
K
L
W
D
Y
S
K
G
K
C
L
K
T
Y
--------
T
--
G
H
K
N
E
K
Y
C
I
F
A
N
F
S
V
T
G
G
K
W
I
V
S
G
S
E
D
N
L
V
Y
I
W
N
L
Q
T
K
E
I
V
Q
K
L
Q
G
H
T
D
V
V
I
S
T
A
C
H
P
T
E
N
I
I
A
S
A
A
L
EN
D
K
T
I
K
L
W
K
--
8
PsiBlast_PDB
59.14
31%
-58
- C1 -
-
3SMR
9
WDR5_HUMAN
A:
[9-309]
---------------------------------------------------------------------------------------------
V
K
P
N
Y
A
L
K
F
T
L
A
G
H
T
K
A
V
S
S
V
K
F
S
-
P
N
-
G
E
W
L
A
S
S
S
A
D
K
L
I
K
I
W
G
A
Y
D
G
K
-
F
E
K
T
I
S
G
H
K
L
G
I
S
D
V
A
W
S
-
S
D
S
N
L
L
V
S
A
S
D
D
K
T
L
K
I
W
D
V
S
S
G
K
----
C
------
L
K
T
-
L
K
G
H
S
N
Y
V
F
C
C
N
F
N
P
Q
-------
S
-
N
L
I
V
S
G
S
F
D
E
S
V
R
I
W
D
V
K
T
G
K
C
L
K
T
L
P
A
H
S
D
P
V
S
A
V
H
F
N
R
--
D
G
S
L
I
V
S
S
S
Y
D
G
L
C
R
I
W
D
T
A
S
G
Q
C
L
-
K
T
L
I
D
--
N
--------
P
P
V
S
F
V
K
F
S
---------------------------------------
P
-----------------------
N
-----------
G
K
Y
I
L
A
A
T
L
D
N
T
L
K
L
W
D
Y
S
K
G
K
C
L
K
T
Y
--------
T
--
G
H
K
N
E
K
Y
C
I
F
A
N
F
S
V
T
G
G
K
W
I
V
S
G
S
E
D
N
L
V
Y
I
W
N
L
Q
T
K
E
I
V
Q
K
L
Q
G
H
T
D
V
V
I
S
T
A
C
H
P
T
E
N
I
I
A
S
A
A
L
EN
D
K
T
I
K
L
W
K
--
38
HHSearch
59.08
27%
-6
- C1 -
-
5MQF
-
SNR40_HUMAN
F:
[60-357]
-----------------------------------------------------------------------------------------------------
M
L
L
S
G
H
E
G
E
V
Y
C
C
K
F
H
-
P
N
-
G
S
T
L
A
S
A
G
F
D
R
L
I
L
L
W
N
V
Y
G
D
C
D
N
Y
A
T
L
K
G
H
S
G
A
V
M
E
L
H
Y
N
-
T
D
G
S
M
L
F
S
A
S
T
D
K
T
V
A
V
W
D
S
E
T
G
E
----
R
------
V
K
R
-
L
K
G
H
T
S
F
V
N
S
C
Y
P
A
R
R
-------
G
P
Q
L
V
C
T
G
S
D
D
G
T
V
K
L
W
D
I
R
K
K
A
A
I
Q
T
F
Q
-
N
T
Y
Q
V
L
A
V
T
F
N
D
--
T
S
D
Q
I
I
S
G
G
I
D
N
D
I
K
V
W
D
L
R
Q
N
K
L
T
-
Y
T
M
R
G
H
A
D
S
V
T
G
L
S
L
S
S
E
----------------------------------------------------------------------------------
G
S
Y
L
L
S
N
A
M
D
N
T
V
R
V
W
D
V
R
P
F
A
P
K
E
R
C
V
K
I
F
Q
GNV
H
--
N
F
E
K
N
L
L
R
C
S
W
S
---
P
D
G
S
K
I
A
A
G
S
A
D
R
F
V
Y
V
W
D
T
T
S
R
R
I
L
Y
K
L
P
G
H
A
G
S
I
N
E
V
A
F
H
P
D
E
P
I
I
I
S
A
S
S
--
D
K
R
L
Y
M
G
E
I
Q
7
PsiBlast_PDB
58.98
31%
-49
- C1 -
-
2H9P
-
WDR5_HUMAN
A:
[26-326]
---------------------------------------------------------------------------------------------
V
K
P
N
Y
A
L
K
F
T
L
A
G
H
T
K
A
V
S
S
V
K
F
S
-
P
N
-
G
E
W
L
A
S
S
S
A
D
K
L
I
K
I
W
G
A
Y
D
G
K
-
F
E
K
T
I
S
G
H
K
L
G
I
S
D
V
A
W
S
-
S
D
S
N
L
L
V
S
A
S
D
D
K
T
L
K
I
W
D
V
S
S
G
K
----
C
------
L
K
T
-
L
K
G
H
S
N
Y
V
F
C
C
N
F
N
P
Q
-------
S
-
N
L
I
V
S
G
S
F
D
E
S
V
R
I
W
D
V
K
T
G
K
C
L
K
T
L
P
A
H
S
D
P
V
S
A
V
H
F
N
R
--
D
G
S
L
I
V
S
S
S
Y
D
G
L
C
R
I
W
D
T
A
S
G
Q
C
L
-
K
T
L
I
D
D
D
N
--------
P
P
V
S
F
V
K
F
S
---------------------------------------
P
-----------------------
N
-----------
G
K
Y
I
L
A
A
T
L
D
N
T
L
K
L
W
D
Y
S
K
G
K
C
L
K
T
Y
--------
T
--
G
H
K
N
E
K
Y
C
I
F
A
N
F
S
V
T
G
G
K
W
I
V
S
G
S
E
D
N
L
V
Y
I
W
N
L
Q
T
K
E
I
V
Q
K
L
Q
G
H
T
D
V
V
I
S
T
A
C
H
P
T
E
N
I
I
A
S
A
A
L
EN
D
K
T
I
K
L
W
K
--