@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PTN11_MOUSE: (2018-07-13 )
MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQALLQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIVDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLVDQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQRSFRENTREESDIFFERENTES
Atome Classification :
(24 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160...-....170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370....---...380.......390.......400.......410.......420.......430.......440.......450--------.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610...
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MTSR
R
W
FHPNITGVEAE
N
L
L
L
TRGVD
G
S
FLARPSKSNPG
D
F
T
L
S
V
RRNG
A
V
T
H
I
K
I
QNTGDYYDLYGG
E
K
F
A
T
L
A
E
L
V
Q
Y
Y
M
E
HHGQLKEKNG
D
V
I
E
L
KYPLNCADPTSER
W
F
HGHLS
G
K
E
A
E
K
L
L
T
EKGKHG
S
F
L
V
RESQSHPG
D
F
V
L
S
V
RTGDDKGESND
G
K
S
-
K
V
T
H
V
M
I
R
C
Q
E
L
K
YDVGGGE
R
F
D
S
L
T
D
L
V
E
H
Y
KKN
P
M
V
E
T
L
G
T
V
L
Q
L
KQPLNTTRI
N
A
A
E
I
E
S
R
V
R
E
L
S
K
L
A
E
T
T
D
K
V
K
Q
G
F
W
E
E
F
E
T
L
Q
Q
Q
E
C
K
L
L
Y
SRKEGQRQENKNKNRYKNILPFD
H
T
R
V
V
L
HDGDPNE
P
V
S
D
YINA
N
I
IMPEFETKCNNSKPK
K
S
Y
I
A
T
Q
G
C
L
Q
N
T
V
N
D
F
W
R
M
V
F
QEN
S
R
V
I
V
M
T
T
K
E
V
E
R
G
K
S
K
C
V
KYW
P
D
E
Y
A
---
L
K
E
Y
G
V
M
R
V
R
N
V
K
E
SAAHD
Y
T
L
R
E
L
K
L
S
K
V
G
Q
A
L
LQGNTE
R
T
V
W
Q
Y
HFRTWPDHGVPSDP
G
G
V
L
D
F
L
E
E
V
H
H
K
Q
E
S--------IVDAG
P
V
V
V
H
CSAGIGRT
G
T
F
I
V
I
D
I
L
I
D
I
I
R
EKGVDCDIDV
P
K
T
I
Q
M
V
R
S
QRSGMVQTEA
Q
Y
R
F
I
Y
M
A
V
Q
H
Y
I
E
T
L
Q
R
R
I
E
E
E
Q
K
S
KRKGHEYT
N
I
K
Y
S
L
VDQTSGDQSPLPPCTPTP
P
C
A
E
M
R
E
D
S
A
R
V
Y
E
N
V
G
L
M
Q
Q
Q
R
S
F
R
ENTREES
D
I
F
F
ERENTES
2
PsiBlast_PDB
92.54
98%
-71
- C1 -
-
5XZR
1
PTN11_HUMAN
A:
[24-557]
M
T
S
R
R
W
F
H
P
N
I
T
G
V
E
A
E
N
L
L
L
T
R
G
V
D
G
S
F
L
A
R
P
S
K
S
N
P
G
D
F
T
L
S
V
R
R
N
G
A
V
T
H
I
K
I
Q
N
T
G
D
Y
Y
D
L
Y
G
G
E
K
F
A
T
L
A
A
L
V
Q
Y
Y
M
E
H
H
G
Q
L
K
E
K
N
G
D
V
I
E
L
K
Y
P
L
N
C
A
D
P
T
S
E
R
W
F
H
G
H
L
S
G
K
E
A
E
K
L
L
T
E
K
G
K
H
G
S
F
L
V
R
E
S
Q
S
H
P
G
D
F
V
L
S
V
R
T
G
D
D
K
G
E
S
N
D
G
K
S
-
K
V
T
H
V
M
I
R
C
Q
E
L
K
Y
D
V
G
G
G
E
R
F
D
S
L
T
D
L
V
E
H
Y
K
K
N
P
M
V
E
T
L
G
T
V
L
Q
L
K
Q
P
L
N
T
T
R
I
N
A
A
E
I
E
S
R
V
R
E
L
S
K
L
A
E
---
K
V
K
Q
G
F
W
E
E
F
E
T
L
Q
Q
Q
E
C
K
L
L
Y
S
R
K
E
G
Q
R
Q
E
N
K
N
K
N
R
Y
K
N
I
L
P
F
D
H
T
R
V
V
L
H
D
G
D
P
N
E
P
V
S
D
Y
I
N
A
N
I
I
M
P
------------
K
S
Y
I
A
T
Q
G
C
L
Q
N
T
V
N
D
F
W
R
M
V
F
Q
E
N
S
R
V
I
V
M
T
T
K
E
V
E
R
G
K
S
K
C
V
K
Y
W
P
D
E
Y
A
---
L
K
E
Y
G
V
M
R
V
R
N
V
K
E
S
A
A
H
D
Y
T
L
R
E
L
K
L
S
K
V
G
----
Q
G
N
T
E
R
T
V
W
Q
Y
H
F
R
T
W
P
D
H
G
V
P
S
D
P
G
G
V
L
D
F
L
E
E
V
H
H
K
Q
E
S
--------
I
M
D
A
G
P
V
V
V
H
C
S
A
G
I
G
R
T
G
T
F
I
V
I
D
I
L
I
D
I
I
R
E
K
G
V
D
C
D
I
D
V
P
K
T
I
Q
M
V
R
S
Q
R
S
G
M
V
Q
T
E
A
Q
Y
R
F
I
Y
M
A
V
Q
H
Y
I
E
T
L
Q
R
R
I
E
E
E
Q
K
-----------------------------------------------------------------------------
1
PsiBlast_PDB
92.28
98%
-83
- C1 -
-
4NWG
8
PTN11_HUMAN
A:
[2-534]
-
T
S
R
R
W
F
H
P
N
I
T
G
V
E
A
E
N
L
L
L
T
R
G
V
D
G
S
F
L
A
R
P
--
S
N
P
G
D
F
T
L
S
V
R
R
N
G
A
V
T
H
I
K
I
Q
N
T
G
D
Y
Y
D
L
Y
G
G
E
K
F
A
T
L
A
E
L
V
Q
Y
Y
M
E
H
H
G
Q
L
K
E
K
N
G
D
V
I
E
L
K
Y
P
L
N
C
A
D
P
T
S
E
R
W
F
H
G
H
L
S
G
--
A
E
K
L
L
T
E
K
G
K
H
G
S
F
L
V
R
D
S
Q
S
H
P
G
D
F
V
L
S
V
R
T
G
D
---------
S
-
K
V
T
H
V
M
I
R
C
Q
E
L
K
Y
D
V
G
G
G
E
R
F
D
S
L
T
D
L
V
E
H
Y
K
K
N
P
M
V
E
T
L
G
T
V
L
Q
L
K
Q
P
L
N
T
T
R
I
N
A
A
E
I
E
S
R
V
R
E
L
S
-----------
G
F
W
E
E
F
E
T
L
Q
Q
Q
E
C
K
L
L
Y
S
R
K
E
G
Q
R
Q
E
N
K
N
K
N
R
Y
K
N
I
L
P
F
D
H
T
R
V
V
L
H
D
G
D
P
N
-
P
V
S
D
Y
I
N
A
N
I
I
M
P
E
----------
K
K
S
Y
I
A
T
Q
G
C
L
Q
N
T
V
N
D
F
W
R
M
V
F
Q
E
N
S
R
V
I
V
M
T
T
K
E
V
E
R
G
K
S
K
C
V
K
Y
W
P
D
E
Y
A
---
L
K
E
Y
G
V
M
R
V
R
N
V
K
E
S
A
A
H
D
Y
T
L
R
E
L
K
L
S
K
V
G
----
Q
G
N
T
E
R
T
V
W
Q
Y
H
F
R
T
W
P
D
H
G
V
P
S
D
P
G
G
V
L
D
F
L
E
E
V
H
H
K
Q
E
S
--------
I
M
D
A
G
P
V
V
V
H
C
S
A
G
I
G
R
T
G
T
F
I
V
I
D
I
L
I
D
I
I
R
E
K
G
V
D
C
D
I
D
V
P
K
T
I
Q
M
V
R
S
Q
R
S
G
M
V
Q
T
E
A
Q
Y
R
F
I
Y
M
A
V
Q
H
Y
I
E
T
L
Q
R
R
I
E
E
E
Q
K
-----------------------------------------------------------------------------
9
PsiBlast_PDB
92.06
99%
-81
- C1 -
-
6BMX
1
PTN11_HUMAN
A:
[4-526]
--
S
R
R
W
F
H
P
N
I
T
G
V
E
A
E
N
L
L
L
T
R
G
V
D
G
S
F
L
A
R
P
S
K
S
N
P
G
D
F
T
L
S
V
R
R
N
G
A
V
T
H
I
K
I
Q
N
T
G
D
Y
Y
D
L
Y
G
G
E
K
F
A
T
L
A
E
L
V
Q
Y
Y
M
E
H
H
G
Q
L
K
E
-
N
G
D
V
I
E
L
K
Y
P
L
N
C
A
D
P
T
S
E
R
W
F
H
G
H
L
S
G
K
E
A
E
K
L
L
T
E
K
G
K
H
G
S
F
L
V
R
E
S
---
P
G
D
F
V
L
S
V
R
T
G
----------
S
-
K
V
T
H
V
M
I
R
C
Q
E
L
K
Y
D
V
G
G
G
E
R
F
D
S
L
T
D
L
V
E
H
Y
K
K
N
P
M
V
E
T
L
G
T
V
L
Q
L
K
Q
P
L
N
T
T
R
I
N
A
A
E
I
E
S
R
V
R
E
L
S
K
L
--------
Q
G
F
W
E
E
F
E
T
L
Q
Q
Q
E
C
K
L
L
Y
S
R
K
E
G
Q
R
Q
E
N
K
N
K
N
R
Y
K
N
I
L
P
F
D
H
T
R
V
V
L
H
D
G
D
P
--
P
V
S
D
Y
I
N
A
N
I
I
M
P
E
-----------
K
S
Y
I
A
T
Q
G
C
L
Q
N
T
V
N
D
F
W
R
M
V
F
Q
E
N
S
R
V
I
V
M
T
T
K
E
V
E
R
G
K
S
K
C
V
K
Y
W
P
D
E
Y
A
---
L
K
E
Y
G
V
M
R
V
R
N
V
K
E
S
A
A
H
D
Y
T
L
R
E
L
K
L
S
K
V
G
----
Q
G
N
T
E
R
T
V
W
Q
Y
H
F
R
T
W
P
D
H
G
V
P
S
D
P
G
G
V
L
D
F
L
E
E
V
H
H
K
Q
E
S
--------
I
M
D
A
G
P
V
V
V
H
C
S
A
G
I
G
R
T
G
T
F
I
V
I
D
I
L
I
D
I
I
R
E
K
G
V
D
C
D
I
D
V
P
K
T
I
Q
M
V
R
S
Q
R
S
G
M
V
Q
T
E
A
Q
Y
R
F
I
Y
M
A
V
Q
H
Y
I
E
T
L
--------------------------------------------------------------------------------------
5
PsiBlast_PDB
91.56
99%
-81
- C1 -
-
6BMR
1
PTN11_HUMAN
A:
[4-526]
--
S
R
R
W
F
H
P
N
I
T
G
V
E
A
E
N
L
L
L
T
R
G
V
D
G
S
F
L
A
R
P
S
K
S
N
P
G
D
F
T
L
S
V
R
R
N
G
A
V
T
H
I
K
I
Q
N
T
G
D
Y
Y
D
L
Y
G
G
E
K
F
A
T
L
A
E
L
V
Q
Y
Y
M
E
H
H
G
Q
L
K
E
-
N
G
D
V
I
E
L
K
Y
P
L
N
C
A
D
P
T
S
E
R
W
F
H
G
H
L
S
G
K
E
A
E
K
L
L
T
E
K
G
K
H
G
S
F
L
V
R
E
S
Q
--
P
G
D
F
V
L
S
V
R
T
G
----------
S
-
K
V
T
H
V
M
I
R
C
Q
E
L
K
Y
D
V
G
G
G
E
R
F
D
S
L
T
D
L
V
E
H
Y
K
K
N
P
M
V
E
T
L
G
T
V
L
Q
L
K
Q
P
L
N
T
T
R
I
N
A
A
E
I
E
S
R
V
R
E
L
S
K
L
--------
Q
G
F
W
E
E
F
E
T
L
Q
Q
Q
E
C
K
L
L
Y
S
R
K
E
G
Q
R
Q
E
N
K
N
K
N
R
Y
K
N
I
L
P
F
D
H
T
R
V
V
L
H
D
G
D
P
--
P
V
S
D
Y
I
N
A
N
I
I
M
P
E
-----------
K
S
Y
I
A
T
Q
G
C
L
Q
N
T
V
N
D
F
W
R
M
V
F
Q
E
N
S
R
V
I
V
M
T
T
K
E
V
E
R
G
K
S
K
C
V
K
Y
W
P
D
E
Y
A
---
L
K
E
Y
G
V
M
R
V
R
N
V
K
E
S
A
A
H
D
Y
T
L
R
E
L
K
L
S
K
V
G
----
Q
G
N
T
E
R
T
V
W
Q
Y
H
F
R
T
W
P
D
H
G
V
P
S
D
P
G
G
V
L
D
F
L
E
E
V
H
H
K
Q
E
S
--------
I
M
D
A
G
P
V
V
V
H
C
S
A
G
I
G
R
T
G
T
F
I
V
I
D
I
L
I
D
I
I
R
E
K
G
V
D
C
D
I
D
V
P
K
T
I
Q
M
V
R
S
Q
R
S
G
M
V
Q
T
E
A
Q
Y
R
F
I
Y
M
A
V
Q
H
Y
I
E
T
L
--------------------------------------------------------------------------------------
10
PsiBlast_PDB
90.80
99%
-85
- C1 -
-
6BMY
2
PTN11_HUMAN
A:
[4-526]
--
S
R
R
W
F
H
P
N
I
T
G
V
E
A
E
N
L
L
L
T
R
G
V
D
G
S
F
L
A
R
P
S
--
N
P
G
D
F
T
L
S
V
R
R
N
G
A
V
T
H
I
K
I
Q
N
T
G
D
Y
Y
D
L
Y
G
G
E
K
F
A
T
L
A
E
L
V
Q
Y
Y
M
E
H
H
G
Q
L
K
---
G
D
V
I
E
L
K
Y
P
L
N
C
A
D
P
T
S
E
R
W
F
H
G
H
L
-----
E
K
L
L
T
E
K
G
K
H
G
S
F
L
V
R
E
S
---
P
G
D
F
V
L
S
V
R
T
G
----------
S
-
K
V
T
H
V
M
I
R
C
Q
E
L
K
Y
D
V
G
G
G
E
R
F
D
S
L
T
D
L
V
E
H
Y
K
K
N
P
M
V
E
T
L
G
T
V
L
Q
L
K
Q
P
L
N
T
T
R
I
N
A
A
E
I
E
S
R
V
R
E
L
S
K
L
--------
Q
G
F
W
E
E
F
E
T
L
Q
Q
Q
E
C
K
L
L
Y
S
R
K
E
G
Q
R
Q
E
N
K
N
K
N
R
Y
K
N
I
L
P
F
D
H
T
R
V
V
L
H
D
G
D
P
--
P
V
S
D
Y
I
N
A
N
I
I
M
P
----------
P
K
K
S
Y
I
A
T
Q
G
C
L
Q
N
T
V
N
D
F
W
R
M
V
F
Q
E
N
S
R
V
I
V
M
T
T
K
E
V
E
R
G
K
S
K
C
V
K
Y
W
P
D
E
Y
A
---
L
K
E
Y
G
V
M
R
V
R
N
V
K
E
S
A
A
H
D
Y
T
L
R
E
L
K
L
S
K
V
G
----
Q
G
N
T
E
R
T
V
W
Q
Y
H
F
R
T
W
P
D
H
G
V
P
S
D
P
G
G
V
L
D
F
L
E
E
V
H
H
K
Q
E
S
--------
I
M
D
A
G
P
V
V
V
H
C
S
A
G
I
G
R
T
G
T
F
I
V
I
D
I
L
I
D
I
I
R
E
K
G
V
D
C
D
I
D
V
P
K
T
I
Q
M
V
R
S
Q
R
S
G
M
V
Q
T
E
A
Q
Y
R
F
I
Y
M
A
V
Q
H
Y
I
E
T
L
--------------------------------------------------------------------------------------
7
PsiBlast_PDB
90.75
99%
-85
- C1 -
-
6BMV
1
PTN11_HUMAN
A:
[4-526]
--
S
R
R
W
F
H
P
N
I
T
G
V
E
A
E
N
L
L
L
T
R
G
V
D
G
S
F
L
A
R
P
S
K
S
N
P
G
D
F
T
L
S
V
R
R
N
G
A
V
T
H
I
K
I
Q
N
T
G
D
Y
Y
D
L
Y
G
G
E
K
F
A
T
L
A
E
L
V
Q
Y
Y
M
E
H
H
G
Q
L
K
--
N
G
D
V
I
E
L
K
Y
P
L
N
C
A
D
P
T
S
E
R
W
F
H
G
H
L
S
G
K
E
A
E
K
L
L
T
E
K
G
K
H
G
S
F
L
V
R
E
S
Q
--
P
G
D
F
V
L
S
V
R
T
G
----------
S
-
K
V
T
H
V
M
I
R
C
Q
E
L
K
Y
D
V
G
G
G
E
R
F
D
S
L
T
D
L
V
E
H
Y
K
K
N
P
M
V
E
T
L
G
T
V
L
Q
L
K
Q
P
L
N
T
T
R
I
N
A
A
E
I
E
S
R
V
R
E
L
S
---------
K
Q
G
F
W
E
E
F
E
T
L
Q
Q
Q
E
C
K
L
L
Y
S
R
K
E
G
Q
R
Q
E
N
K
N
K
N
R
Y
K
N
I
L
P
F
D
H
T
R
V
V
L
H
------
P
V
S
D
Y
I
N
A
N
I
I
M
P
E
-----------
K
S
Y
I
A
T
Q
G
C
L
Q
N
T
V
N
D
F
W
R
M
V
F
Q
E
N
S
R
V
I
V
M
T
T
K
E
V
E
R
G
K
S
K
C
V
K
Y
W
P
D
E
Y
A
---
L
K
E
Y
G
V
M
R
V
R
N
V
K
E
S
A
A
H
D
Y
T
L
R
E
L
K
L
S
K
V
G
----
Q
G
N
T
E
R
T
V
W
Q
Y
H
F
R
T
W
P
D
H
G
V
P
S
D
P
G
G
V
L
D
F
L
E
E
V
H
H
K
Q
E
S
--------
I
M
D
A
G
P
V
V
V
H
C
S
A
G
I
G
R
T
G
T
F
I
V
I
D
I
L
I
D
I
I
R
E
K
G
V
D
C
D
I
D
V
P
K
T
I
Q
M
V
R
S
Q
R
S
G
M
V
Q
T
E
A
Q
Y
R
F
I
Y
M
A
V
Q
H
Y
I
E
T
L
--------------------------------------------------------------------------------------
3
PsiBlast_PDB
90.71
98%
-70
- C1 -
-
4OHI
-
PTN11_HUMAN
A:
[3-528]
--
S
R
R
W
F
H
P
N
I
T
G
V
E
A
E
N
L
L
L
T
R
G
V
D
G
S
F
L
A
R
P
S
K
S
N
P
G
D
F
T
L
S
V
R
R
N
G
A
V
T
H
I
K
I
Q
N
T
G
D
Y
Y
D
L
Y
G
G
E
K
F
A
T
L
A
E
L
V
Q
Y
Y
M
E
H
H
G
Q
L
K
E
K
N
G
D
V
I
E
L
K
Y
P
L
N
C
A
D
P
T
S
E
R
W
F
H
G
H
L
S
G
K
E
A
E
K
L
L
T
E
K
G
K
H
G
S
F
L
V
R
E
S
Q
S
H
P
G
D
F
V
L
S
V
R
T
G
D
D
K
G
E
S
N
D
G
K
S
-
K
V
T
H
V
M
I
R
C
Q
E
L
K
Y
D
V
G
G
G
E
R
F
D
S
L
T
D
L
V
E
H
Y
K
K
N
P
M
V
E
T
L
G
T
V
L
Q
L
K
Q
P
L
N
T
T
R
I
N
A
A
E
I
E
S
R
V
R
E
L
S
-------
K
V
K
Q
G
F
W
E
E
F
E
T
L
Q
Q
Q
E
C
K
L
L
Y
S
R
K
E
G
Q
R
Q
E
N
K
N
K
N
R
Y
K
N
I
L
P
F
D
H
T
R
V
V
L
H
D
-------
S
D
Y
I
N
A
N
I
I
M
P
E
----------
K
K
S
Y
I
A
T
Q
G
C
L
Q
N
T
V
N
D
F
W
R
M
V
F
Q
E
N
S
R
V
I
V
M
T
T
K
E
V
E
R
G
K
S
K
C
V
K
Y
W
P
D
E
Y
A
---
L
K
E
Y
G
V
M
R
V
R
N
V
K
E
S
A
A
H
D
Y
T
L
R
E
L
K
L
S
K
V
G
----
Q
G
N
T
E
R
T
V
W
Q
Y
H
F
R
T
W
P
D
H
G
V
P
S
D
P
G
G
V
L
D
F
L
E
E
V
H
H
K
Q
E
S
--------
I
M
D
A
G
P
V
V
V
H
C
S
A
G
I
G
R
T
G
T
F
I
V
I
D
I
L
I
D
I
I
R
E
K
G
V
D
C
D
I
D
V
P
K
T
I
Q
M
V
R
S
Q
R
S
G
M
V
Q
T
E
A
E
Y
R
F
I
Y
M
A
V
Q
H
Y
I
E
T
L
Q
R
R
-----------------------------------------------------------------------------------
6
PsiBlast_PDB
89.92
99%
-85
- C1 -
-
6BMU
3
PTN11_HUMAN
A:
[4-526]
--
S
R
R
W
F
H
P
N
I
T
G
V
E
A
E
N
L
L
L
T
R
G
V
D
G
S
F
L
A
R
P
S
--
N
P
G
D
F
T
L
S
V
R
R
N
G
A
V
T
H
I
K
I
Q
N
T
G
D
Y
Y
D
L
Y
G
G
E
K
F
A
T
L
A
E
L
V
Q
Y
Y
M
E
H
H
G
Q
L
K
---
G
D
V
I
E
L
K
Y
P
L
N
C
A
D
P
T
S
E
R
W
F
H
G
H
L
-----
E
K
L
L
T
E
K
G
K
H
G
S
F
L
V
R
E
S
---
P
G
D
F
V
L
S
V
R
T
G
----------
S
-
K
V
T
H
V
M
I
R
C
Q
E
L
K
Y
D
V
G
G
G
E
R
F
D
S
L
T
D
L
V
E
H
Y
K
K
N
P
M
V
E
T
L
G
T
V
L
Q
L
K
Q
P
L
N
T
T
R
I
N
A
A
E
I
E
S
R
V
R
E
L
S
K
L
--------
Q
G
F
W
E
E
F
E
T
L
Q
Q
Q
E
C
K
L
L
Y
S
R
K
E
G
Q
R
Q
E
N
K
N
K
N
R
Y
K
N
I
L
P
F
D
H
T
R
V
V
L
H
D
G
D
P
--
P
V
S
D
Y
I
N
A
N
I
I
M
P
----------
P
K
K
S
Y
I
A
T
Q
G
C
L
Q
N
T
V
N
D
F
W
R
M
V
F
Q
E
N
S
R
V
I
V
M
T
T
K
E
V
E
R
G
K
S
K
C
V
K
Y
W
P
D
E
Y
A
---
L
K
E
Y
G
V
M
R
V
R
N
V
K
E
S
A
A
H
D
Y
T
L
R
E
L
K
L
S
K
V
G
----
Q
G
N
T
E
R
T
V
W
Q
Y
H
F
R
T
W
P
D
H
G
V
P
S
D
P
G
G
V
L
D
F
L
E
E
V
H
H
K
Q
E
S
--------
I
M
D
A
G
P
V
V
V
H
C
S
A
G
I
G
R
T
G
T
F
I
V
I
D
I
L
I
D
I
I
R
E
K
G
V
D
C
D
I
D
V
P
K
T
I
Q
M
V
R
S
Q
R
S
G
M
V
Q
T
E
A
Q
Y
R
F
I
Y
M
A
V
Q
H
Y
I
E
T
L
--------------------------------------------------------------------------------------
4
PsiBlast_PDB
89.86
98%
-77
- C- -
-
4OHH
-
PTN11_HUMAN
A:
[3-528]
--
S
R
R
W
F
H
P
N
I
T
G
V
E
A
E
N
L
L
L
T
R
G
V
D
G
S
F
L
A
R
P
S
K
S
N
P
G
D
F
T
L
S
V
R
R
N
G
A
V
T
H
I
K
I
Q
N
T
G
D
Y
Y
D
L
Y
G
G
E
K
F
A
T
L
A
E
L
V
Q
Y
Y
M
E
H
H
G
Q
L
K
E
K
N
G
D
V
I
E
L
K
Y
P
L
N
C
A
D
P
T
S
E
R
W
F
H
G
H
L
S
G
K
E
A
E
K
L
L
T
E
K
G
K
H
G
S
F
L
V
R
E
S
Q
S
H
P
G
D
F
V
L
S
V
R
T
G
D
D
----
N
D
G
K
S
-
K
V
T
H
V
M
I
R
C
Q
E
L
K
Y
D
V
G
G
G
E
R
F
D
S
L
T
D
L
V
E
H
Y
K
K
N
P
M
V
E
T
L
G
T
V
L
Q
L
K
Q
P
L
N
T
T
R
I
N
A
A
E
I
E
S
R
V
R
E
L
S
-----------
G
F
W
E
E
F
E
T
L
Q
Q
Q
E
C
K
L
L
Y
S
R
K
E
G
Q
R
Q
E
N
K
N
K
N
R
Y
K
N
I
L
P
F
D
H
T
R
V
V
L
H
D
-------
S
D
Y
I
N
A
N
I
I
M
P
E
----------
K
K
S
Y
I
A
T
Q
G
C
L
Q
N
T
V
N
D
F
W
R
M
V
F
Q
E
N
S
R
V
I
V
M
T
T
K
E
V
E
R
G
K
S
K
C
V
K
Y
W
P
D
E
Y
A
---
L
K
E
Y
G
V
M
R
V
R
N
V
K
E
S
A
A
H
D
Y
T
L
R
E
L
K
L
S
K
V
G
----
Q
G
N
T
E
R
T
V
W
Q
Y
H
F
R
T
W
P
D
H
G
V
P
S
D
P
G
G
V
L
D
F
L
E
E
V
H
H
K
Q
E
S
--------
I
M
D
A
G
P
V
V
V
H
C
S
A
G
I
G
R
T
G
T
F
I
V
I
D
I
L
I
D
I
I
R
E
K
G
V
D
C
D
I
D
V
P
K
T
I
Q
M
V
R
S
Q
R
S
G
M
V
P
T
E
A
Q
Y
R
F
I
Y
M
A
V
Q
H
Y
I
E
T
L
Q
R
R
-----------------------------------------------------------------------------------
8
PsiBlast_PDB
89.77
99%
-90
- C1 -
-
6BMW
2
PTN11_HUMAN
A:
[4-526]
--
S
R
R
W
F
H
P
N
I
T
G
V
E
A
E
N
L
L
L
T
R
G
V
D
G
S
F
L
A
R
P
S
K
--
P
G
D
F
T
L
S
V
R
R
N
G
A
V
T
H
I
K
I
Q
N
T
G
D
Y
Y
D
L
Y
G
G
E
K
F
A
T
L
A
E
L
V
Q
Y
Y
M
E
H
H
G
Q
L
K
----
D
V
I
E
L
K
Y
P
L
N
C
A
D
P
T
S
E
R
W
F
H
G
H
L
---
E
A
E
K
L
L
T
E
K
G
K
H
G
S
F
L
V
R
E
S
---
P
G
D
F
V
L
S
V
R
T
G
----------
S
-
K
V
T
H
V
M
I
R
C
Q
E
L
K
Y
D
V
G
G
G
E
R
F
D
S
L
T
D
L
V
E
H
Y
K
K
N
P
M
V
E
T
L
G
T
V
L
Q
L
K
Q
P
L
N
T
T
R
I
N
A
A
E
I
E
S
R
V
R
E
L
S
K
L
--------
Q
G
F
W
E
E
F
E
T
L
Q
Q
Q
E
C
K
L
L
Y
S
R
K
E
G
Q
R
Q
E
N
K
N
K
N
R
Y
K
N
I
L
P
F
D
H
T
R
V
V
L
H
------
P
V
S
D
Y
I
N
A
N
I
I
M
P
------------
K
S
Y
I
A
T
Q
G
C
L
Q
N
T
V
N
D
F
W
R
M
V
F
Q
E
N
S
R
V
I
V
M
T
T
K
E
V
E
R
G
K
S
K
C
V
K
Y
W
P
D
E
Y
A
---
L
K
E
Y
G
V
M
R
V
R
N
V
K
E
S
A
A
H
D
Y
T
L
R
E
L
K
L
S
K
V
G
----
Q
G
N
T
E
R
T
V
W
Q
Y
H
F
R
T
W
P
D
H
G
V
P
S
D
P
G
G
V
L
D
F
L
E
E
V
H
H
K
Q
E
S
--------
I
M
D
A
G
P
V
V
V
H
C
S
A
G
I
G
R
T
G
T
F
I
V
I
D
I
L
I
D
I
I
R
E
K
G
V
D
C
D
I
D
V
P
K
T
I
Q
M
V
R
S
Q
R
S
G
M
V
Q
T
E
A
Q
Y
R
F
I
Y
M
A
V
Q
H
Y
I
E
T
L
--------------------------------------------------------------------------------------
11
PsiBlast_PDB
76.10
55%
-20
- C1 -
-
3PS5
-
PTN6_HUMAN
A:
[3-529]
----
R
W
F
H
R
D
L
S
G
L
D
A
E
T
L
L
K
G
R
G
V
H
G
S
F
L
A
R
P
S
R
K
N
Q
G
D
F
S
L
S
V
R
V
G
D
Q
V
T
H
I
R
I
Q
N
S
G
D
F
Y
D
L
Y
G
G
E
K
F
A
T
L
T
E
L
V
E
Y
Y
T
Q
Q
Q
G
V
L
Q
D
R
D
G
T
I
I
H
L
K
Y
P
L
N
C
S
D
P
T
S
E
R
W
Y
H
G
H
M
S
G
G
Q
A
E
T
L
L
Q
A
K
G
E
P
W
T
F
L
V
R
E
S
L
S
Q
P
G
D
F
V
L
S
V
L
S
--
D
Q
P
K
A
G
P
G
S
P
L
R
V
T
H
I
K
V
M
C
E
G
G
R
Y
T
V
G
G
L
E
T
F
D
S
L
T
D
L
V
E
H
F
K
K
T
G
I
E
E
A
S
G
A
F
V
Y
L
R
Q
P
Y
Y
A
T
R
V
N
A
A
D
I
E
N
R
V
L
E
L
N
K
K
Q
E
S
E
D
T
A
K
A
G
F
W
E
E
F
E
S
L
Q
K
Q
E
V
K
N
L
H
Q
R
L
E
G
Q
R
P
E
N
K
G
K
N
R
Y
K
N
I
L
P
F
D
H
S
R
V
I
L
Q
G
R
D
S
N
I
P
G
S
D
Y
I
N
A
N
Y
I
K
N
Q
L
L
G
P
D
E
N
A
---
K
T
Y
I
A
S
Q
G
C
L
E
A
T
V
N
D
F
W
Q
M
A
W
Q
E
N
S
R
V
I
V
M
T
T
R
E
V
E
K
G
R
N
K
C
V
P
Y
W
P
E
V
G
M
---
Q
R
A
Y
G
P
Y
S
V
T
N
C
G
E
H
D
T
T
E
Y
K
L
R
T
L
Q
V
S
----
P
L
D
N
G
D
L
I
R
E
I
W
H
Y
Q
Y
L
S
W
P
D
H
G
V
P
S
E
P
G
G
V
L
S
F
L
D
Q
I
N
Q
R
Q
E
S
--------
L
P
H
A
G
P
I
I
V
H
S
S
A
G
I
G
R
T
G
T
I
I
V
I
D
M
L
M
E
N
I
S
T
K
G
L
D
C
D
I
D
I
Q
K
T
I
Q
M
V
R
A
Q
R
S
G
M
V
Q
T
E
A
Q
Y
K
F
I
Y
V
A
I
A
Q
F
I
E
T
T
K
K
K
L
E
V
L
Q
S
Q
----------------------------------------------------------------------------
12
PsiBlast_PDB
66.97
97%
-84
- C1 -
-
3B7O
-
PTN11_HUMAN
A:
[33-315]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
F
W
E
E
F
E
T
L
Q
Q
Q
E
C
K
L
L
Y
S
R
K
E
G
Q
R
Q
E
N
K
N
K
N
R
Y
K
N
I
L
P
F
D
H
T
R
V
V
L
H
D
G
D
P
N
E
P
V
S
D
Y
I
N
A
N
I
I
M
P
E
-----------
K
S
Y
I
A
T
Q
G
C
L
Q
N
T
V
N
D
F
W
R
M
V
F
Q
E
N
S
R
V
I
V
M
T
T
K
E
V
E
R
G
K
S
K
C
V
K
Y
W
P
D
E
Y
A
---
L
K
E
Y
G
V
M
R
V
R
N
V
K
E
S
A
A
H
D
Y
T
L
R
E
L
K
L
S
K
V
G
----
Q
G
N
T
E
R
T
V
W
Q
Y
H
F
R
T
W
P
D
H
G
V
P
S
D
P
G
G
V
L
D
F
L
E
E
V
H
H
K
Q
E
S
--------
I
M
D
A
G
P
V
V
V
H
C
S
A
G
I
G
R
T
G
T
F
I
V
I
D
I
L
I
D
I
I
R
E
K
G
V
D
C
D
I
D
V
P
K
T
I
Q
M
V
R
S
Q
R
S
G
M
V
Q
T
E
A
Q
Y
R
F
I
Y
M
A
V
Q
H
Y
I
E
T
L
Q
R
R
-----------------------------------------------------------------------------------
19
PsiBlast_PDB
66.81
97%
-89
- C1 -
-
4RDD
1
PTN11_HUMAN
A:
[1-267]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Y
S
R
K
E
G
Q
R
Q
E
N
K
N
K
N
R
Y
K
N
I
L
P
F
D
H
T
R
V
V
L
H
D
G
D
P
N
E
P
V
S
D
Y
I
N
A
N
I
I
M
P
E
F
E
T
K
C
N
N
S
K
P
K
K
S
Y
I
A
T
Q
G
C
L
Q
N
T
V
N
D
F
W
R
M
V
F
Q
E
N
S
R
V
I
V
M
T
T
K
E
V
E
R
G
K
S
K
C
V
K
Y
W
P
D
E
Y
A
---
L
K
E
Y
G
V
M
R
V
R
N
V
K
E
S
A
A
H
D
Y
T
L
R
E
L
K
L
S
K
V
G
----
Q
G
N
T
E
R
T
V
W
Q
Y
H
F
R
T
W
P
D
H
G
V
P
S
D
P
G
G
V
L
D
F
L
E
E
V
H
H
K
Q
E
S
--------
I
M
D
A
G
P
V
V
V
H
C
S
A
G
I
G
R
T
G
T
F
I
V
I
D
I
L
I
D
I
I
R
E
K
G
V
D
C
D
I
D
V
P
K
T
I
Q
M
V
R
S
Q
R
S
G
M
V
Q
T
E
A
Q
Y
R
F
I
Y
M
A
V
Q
H
Y
I
E
T
L
Q
R
R
-----------------------------------------------------------------------------------
32
HHSearch
66.42
94%
-84
- C1 -
-
3B7O
-
PTN11_HUMAN
A:
[33-314]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
F
W
E
E
F
E
T
L
Q
Q
Q
E
C
K
L
L
Y
S
R
K
E
G
Q
R
Q
E
N
K
N
K
N
R
Y
K
N
I
L
P
F
D
H
T
R
V
V
L
H
D
G
D
P
N
E
P
V
S
D
Y
I
N
A
N
I
I
M
P
E
-----------
K
S
Y
I
A
T
Q
G
C
L
Q
N
T
V
N
D
F
W
R
M
V
F
Q
E
N
S
R
V
I
V
M
T
T
K
E
V
E
R
G
K
S
K
C
V
K
Y
W
P
D
E
Y
A
---
L
K
E
Y
G
V
M
R
V
R
N
V
K
E
S
A
A
H
D
Y
T
L
R
E
L
K
L
S
K
V
G
----
Q
G
N
T
E
R
T
V
W
Q
Y
H
F
R
T
W
P
D
H
G
V
P
S
D
P
G
G
V
L
D
F
L
E
E
V
H
H
K
Q
E
S
--------
I
M
D
A
G
P
V
V
V
H
C
S
A
G
I
G
R
T
G
T
F
I
V
I
D
I
L
I
D
I
I
R
E
K
G
V
D
C
D
I
D
V
P
K
T
I
Q
M
V
R
S
Q
R
S
G
M
V
Q
T
E
A
Q
Y
R
F
I
Y
M
A
V
Q
H
Y
I
E
T
L
Q
R
------------------------------------------------------------------------------------
18
PsiBlast_PDB
65.11
97%
-92
- C1 -
-
3MOW
1
PTN11_HUMAN
A:
[2-266]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Y
S
R
K
E
G
Q
R
Q
E
N
K
N
K
N
R
Y
K
N
I
L
P
F
D
H
T
R
V
V
L
H
D
G
D
P
N
E
P
V
S
D
Y
I
N
A
N
I
I
M
P
E
-----------
K
S
Y
I
A
T
Q
G
C
L
Q
N
T
V
N
D
F
W
R
M
V
F
Q
E
N
S
R
V
I
V
M
T
T
K
E
V
E
R
G
K
S
K
C
V
K
Y
W
P
D
E
Y
A
---
L
K
E
Y
G
V
M
R
V
R
N
V
K
E
S
A
A
H
D
Y
T
L
R
E
L
K
L
S
K
V
G
----
Q
G
N
T
E
R
T
V
W
Q
Y
H
F
R
T
W
P
D
H
G
V
P
S
D
P
G
G
V
L
D
F
L
E
E
V
H
H
K
Q
E
S
--------
I
M
D
A
G
P
V
V
V
H
C
S
A
G
I
G
R
T
G
T
F
I
V
I
D
I
L
I
D
I
I
R
E
K
G
V
D
C
D
I
D
V
P
K
T
I
Q
M
V
R
S
Q
R
S
G
M
V
Q
T
E
A
Q
Y
R
F
I
Y
M
A
V
Q
H
Y
I
E
T
L
Q
-------------------------------------------------------------------------------------
17
PsiBlast_PDB
64.98
97%
-92
- C1 -
-
3O5X
1
PTN11_HUMAN
A:
[2-267]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Y
S
R
K
E
G
Q
R
Q
E
N
K
N
K
N
R
Y
K
N
I
L
P
F
D
H
T
R
V
V
L
H
D
G
D
P
N
E
P
V
S
D
Y
I
N
A
N
I
I
M
P
-----------
K
K
S
Y
I
A
T
Q
G
C
L
Q
N
T
V
N
D
F
W
R
M
V
F
Q
E
N
S
R
V
I
V
M
T
T
K
E
V
E
R
G
K
S
K
C
V
K
Y
W
P
D
E
Y
A
---
L
K
E
Y
G
V
M
R
V
R
N
V
K
E
S
A
A
H
D
Y
T
L
R
E
L
K
L
S
K
V
G
----
Q
G
N
T
E
R
T
V
W
Q
Y
H
F
R
T
W
P
D
H
G
V
P
S
D
P
G
G
V
L
D
F
L
E
E
V
H
H
K
Q
E
S
--------
I
M
D
A
G
P
V
V
V
H
C
S
A
G
I
G
R
T
G
T
F
I
V
I
D
I
L
I
D
I
I
R
E
K
G
V
D
C
D
I
D
V
P
K
T
I
Q
M
V
R
S
Q
R
S
G
M
V
Q
T
E
A
Q
Y
R
F
I
Y
M
A
V
Q
H
Y
I
E
T
L
Q
R
------------------------------------------------------------------------------------
13
PsiBlast_PDB
63.95
97%
-81
- C1 -
-
4PVG
1
PTN11_HUMAN
A:
[13-287]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
T
L
Q
Q
Q
E
C
K
L
L
Y
S
R
K
E
G
Q
R
Q
E
N
K
N
K
N
R
Y
K
N
I
L
P
F
D
H
T
R
V
V
L
H
D
G
D
P
N
E
P
V
S
D
Y
I
N
A
N
I
I
M
P
E
-----------
K
S
Y
I
A
T
Q
G
C
L
Q
N
T
V
N
D
F
W
R
M
V
F
Q
E
N
S
R
V
I
V
M
T
T
K
E
V
E
R
G
K
S
K
C
V
K
Y
W
P
D
E
Y
A
---
L
K
E
Y
G
V
M
R
V
R
N
V
K
E
S
A
A
H
D
Y
T
L
R
E
L
K
L
S
K
V
G
----
Q
G
N
T
E
R
T
V
W
Q
Y
H
F
R
T
W
P
D
H
G
V
P
S
D
P
G
G
V
L
D
F
L
E
E
V
H
H
K
Q
E
S
--------
I
M
D
A
G
P
V
V
V
H
C
S
A
G
I
G
R
T
G
T
F
I
V
I
D
I
L
I
D
I
I
R
E
K
G
V
D
C
D
I
D
V
P
K
T
I
Q
M
V
R
S
Q
R
S
G
M
V
Q
T
E
A
Q
Y
R
F
I
Y
M
A
V
Q
H
Y
I
E
T
L
--------------------------------------------------------------------------------------
38
HHSearch
60.49
38%
-93
- C1 -
-
3I36
-
?
A:
[23-308]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
K
L
I
R
V
E
N
F
E
A
Y
F
K
K
Q
Q
A
------
D
S
N
C
G
F
A
E
E
Y
E
D
L
K
L
I
G
I
S
L
--
P
K
Y
A
A
E
I
A
E
N
R
G
K
N
R
Y
N
N
V
L
P
Y
D
I
S
R
V
K
L
S
V
Q
T
--
H
S
T
D
D
Y
I
N
A
N
Y
M
P
G
Y
H
--------
S
K
K
D
F
I
A
T
Q
G
P
L
P
N
T
L
K
D
F
W
R
M
V
W
E
K
N
V
Y
A
I
V
M
L
T
K
C
V
E
Q
G
R
T
K
C
E
E
Y
W
P
S
K
Q
A
----
Q
D
Y
G
D
I
T
V
A
M
T
S
E
V
V
L
P
E
W
T
I
R
D
F
V
V
K
N
M
Q
-----
S
S
E
S
H
P
L
R
Q
F
H
F
T
S
W
P
D
H
G
V
P
D
T
T
D
L
L
I
N
F
R
Y
L
V
R
D
Y
M
K
Q
--------
I
P
P
E
S
P
I
L
V
H
C
S
A
G
V
G
R
T
G
T
F
I
A
I
D
R
L
I
Y
Q
I
E
N
E
N
---
T
V
D
V
Y
G
I
V
Y
D
L
R
M
H
R
P
L
M
V
Q
T
E
D
Q
Y
V
F
L
N
Q
C
V
L
D
I
I
R
A
Q
K
-------------------------------------------------------------------------------------
34
HHSearch
58.98
37%
-89
- C1 -
-
2NZ6
-
A:
[22-313]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
K
L
I
R
V
E
N
F
E
A
Y
F
K
K
Q
Q
A
------
D
S
N
C
G
F
A
E
E
Y
E
D
L
K
L
V
G
I
S
Q
--
P
K
Y
A
A
E
L
A
E
N
R
G
K
N
R
Y
N
N
V
L
P
Y
D
I
S
R
V
K
L
S
V
Q
T
--
H
S
T
D
D
Y
I
N
A
N
Y
M
P
G
Y
H
--------
S
K
K
D
F
I
A
T
Q
G
P
L
P
N
T
L
K
D
F
W
R
M
V
W
E
K
N
V
Y
A
I
I
M
L
T
K
----------
E
Y
W
P
S
K
Q
A
----
Q
D
Y
G
D
I
T
V
A
M
T
S
E
I
V
L
P
E
W
T
I
R
D
F
T
V
K
N
I
Q
-----
T
S
E
S
H
P
L
R
Q
F
H
F
T
S
W
P
D
H
G
V
P
D
T
T
D
L
L
I
N
F
R
Y
L
V
R
D
Y
M
-------------
E
S
P
I
L
V
H
S
S
A
G
V
G
R
T
G
T
F
I
A
I
D
R
L
I
Y
Q
I
E
N
E
N
---
T
V
D
V
Y
G
I
V
Y
D
L
R
M
H
R
P
L
M
V
Q
T
E
D
Q
Y
V
F
L
N
Q
C
V
L
D
I
V
R
S
Q
K
D
------------------------------------------------------------------------------------
22
Fugue
58.86
37%
-85
- C1 -
-
1JLN
-
PTPRR_MOUSE
A:
[252-548]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
P
R
E
K
V
A
M
E
Y
L
Q
S
A
S
R
V
L
T
R
S
Q
L
R
D
V
V
A
S
-
S
H
L
L
Q
S
E
F
M
E
I
P
----
M
N
F
V
D
P
K
E
I
D
I
P
R
H
G
T
K
N
R
Y
K
T
I
L
P
N
P
L
S
R
V
C
L
R
P
K
N
I
T
D
S
L
S
T
Y
I
N
A
N
Y
I
R
G
-------
Y
S
G
K
E
K
A
F
I
A
T
Q
G
P
M
I
N
T
V
N
D
F
W
Q
M
V
W
Q
E
D
S
P
V
I
V
M
I
T
K
L
K
E
K
N
E
-
K
C
V
L
Y
W
P
E
K
-----
R
G
I
Y
G
K
V
E
V
L
V
T
G
V
T
E
C
D
N
Y
T
I
R
N
L
V
L
K
Q
-------
G
S
H
T
Q
H
V
K
H
Y
W
Y
T
S
W
P
D
H
K
T
P
D
S
A
Q
P
L
L
Q
L
M
L
D
V
E
E
D
R
L
A
--------
S
E
G
R
G
P
V
V
V
H
C
S
A
G
I
G
R
T
G
C
F
I
A
T
S
I
G
C
Q
Q
L
K
E
E
G
---
V
V
D
A
L
S
I
V
C
Q
L
R
V
D
R
G
G
M
V
Q
T
S
E
Q
Y
E
F
V
H
H
A
L
C
L
F
E
S
R
L
S
P
E
T
V
---------------------------------------------------------------------------------
37
HHSearch
55.47
34%
-101
- C1 -
-
4RI5
2
PTN3_HUMAN
A:
[25-303]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
T
L
E
G
S
M
A
Q
L
K
K
G
-----
L
E
S
G
T
V
L
I
Q
F
E
Q
L
Y
R
K
K
P
G
L
--
A
I
T
F
A
K
L
P
Q
N
L
D
K
N
R
Y
K
D
V
L
P
Y
D
T
T
R
V
L
L
Q
G
------
N
E
D
Y
I
N
A
S
Y
V
N
M
E
I
----
P
A
A
N
L
V
N
K
Y
I
A
T
Q
G
P
L
P
H
T
C
A
Q
F
W
Q
V
V
W
D
Q
K
L
S
L
I
V
M
L
T
T
L
T
E
R
G
R
T
K
C
H
Q
Y
W
P
D
P
P
D
---
V
M
N
H
G
G
F
H
I
Q
C
Q
S
E
D
C
T
I
A
Y
V
S
R
E
M
L
V
T
N
T
Q
-----
T
G
E
E
H
T
V
T
H
L
Q
Y
V
A
W
P
E
H
G
V
P
D
D
S
S
D
F
L
E
F
V
N
Y
V
R
S
L
R
-----------
V
D
S
E
P
V
L
V
H
C
S
A
G
I
G
R
T
G
V
L
V
T
M
E
T
A
M
C
L
T
E
R
N
L
---
P
I
Y
P
L
D
I
V
R
K
M
R
D
Q
R
A
M
M
V
Q
T
S
S
Q
Y
K
F
V
C
E
A
I
L
R
V
Y
E
E
G
L
-------------------------------------------------------------------------------------
39
HHSearch
54.85
35%
-100
- C1 -
-
3S3E
3
PTP10_DROME
A:
[19-305]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
H
M
-
A
S
R
P
I
L
I
K
N
F
A
E
H
Y
R
L
M
S
A
D
------
S
D
F
R
F
S
E
E
F
E
E
L
K
H
V
G
R
D
Q
--
P
C
T
F
A
D
L
P
C
N
R
P
K
N
R
F
T
N
I
L
P
Y
D
H
S
R
F
K
L
Q
P
V
D
D
-
D
E
G
S
D
Y
I
N
A
N
Y
V
P
G
H
N
--------
S
P
R
E
F
I
V
T
Q
G
P
L
H
S
T
R
D
D
F
W
R
M
C
W
E
S
N
S
R
A
I
V
M
L
T
R
C
F
E
K
G
R
E
K
C
D
Q
Y
W
P
N
D
T
V
---
P
V
F
Y
G
D
I
K
V
Q
I
L
N
D
S
H
Y
A
D
W
V
M
T
E
F
M
L
C
R
G
-------
S
E
Q
R
I
L
R
H
F
H
F
T
T
W
P
D
F
G
V
P
N
P
P
Q
T
L
V
R
F
V
R
A
F
R
D
R
I
G
----------
A
E
Q
R
P
I
V
V
H
C
S
A
G
V
G
R
S
G
T
F
I
T
L
D
R
I
L
Q
Q
I
N
T
S
D
---
Y
V
D
I
F
G
I
V
Y
A
M
R
K
E
R
V
W
M
V
Q
T
E
Q
Q
Y
I
C
I
H
Q
C
L
L
A
V
L
E
G
K
--------------------------------------------------------------------------------------
45
HHSearch
54.84
38%
-95
- C1 -
-
3O4S
5
PTN7_HUMAN
A:
[40-303]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
P
K
Q
L
E
E
E
F
L
K
I
P
S
N
F
V
S
----
P
E
D
L
D
I
P
G
H
A
S
K
D
R
Y
K
T
I
L
P
N
P
Q
S
R
V
C
L
G
R
A
Q
S
Q
-
E
D
G
D
Y
I
N
A
N
Y
I
R
G
Y
D
-------
G
K
E
K
V
Y
I
A
T
Q
G
P
M
P
N
T
V
S
D
F
W
E
M
V
W
Q
E
E
V
S
L
I
V
M
L
T
Q
L
R
E
-
G
K
E
K
C
V
H
Y
W
P
T
E
E
E
-----
T
Y
G
P
F
Q
I
R
I
Q
D
M
K
E
C
P
E
Y
T
V
R
Q
L
T
I
Q
Y
Q
-------
E
E
R
R
S
V
K
H
I
L
F
S
A
W
P
D
H
Q
T
P
E
S
A
G
P
L
L
R
L
V
A
E
V
E
E
S
P
E
T
--------
A
A
H
P
G
P
I
V
V
H
C
S
A
G
I
G
R
T
G
C
F
I
A
T
R
I
G
C
Q
Q
L
K
A
R
G
---
E
V
D
I
L
G
I
V
C
Q
L
R
L
D
R
G
G
M
I
Q
T
A
E
Q
Y
Q
F
L
H
H
T
L
A
L
Y
A
G
Q
L
P
-------------------------------------------------------------------------------------
44
HHSearch
50.68
32%
-34
- C1 -
-
2BZL
2
A:
[33-322]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
---
F
R
T
L
K
K
K
-----
L
---
M
V
F
T
E
Y
E
Q
I
P
K
K
K
A
N
G
--
I
F
S
T
A
A
L
P
E
N
A
E
R
S
R
I
R
E
V
V
P
Y
E
E
N
R
V
E
L
I
P
T
K
E
--
N
N
T
G
Y
I
N
A
S
H
I
K
V
V
V
------
G
G
A
E
W
H
Y
I
A
T
Q
G
P
L
P
H
T
C
H
D
F
W
Q
M
V
W
E
Q
G
V
N
V
I
A
M
V
T
A
E
E
E
G
G
R
T
K
S
H
R
Y
W
P
K
---KHS
S
A
T
Y
G
K
F
K
V
T
T
K
F
R
T
D
S
V
C
Y
A
T
T
G
L
K
V
K
H
L
L
-----
S
G
Q
E
R
T
V
W
H
L
Q
Y
T
D
W
P
D
H
G
C
P
E
D
V
Q
G
F
L
S
Y
L
E
E
I
Q
S
V
R
R
H
T
N
SMLEGT
K
N
R
H
P
P
I
V
V
H
C
S
A
G
V
G
R
T
G
V
L
I
L
S
E
L
M
I
Y
C
L
E
H
N
E
---
K
V
E
V
P
M
M
L
R
L
L
R
E
Q
R
M
F
M
I
Q
T
I
A
Q
Y
K
F
V
Y
Q
V
L
I
Q
F
L
Q
N
S
--------------------------------------------------------------------------------------