@TOME V2.3
(Mar 2018)
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SIT1_MOUSE: (2018-07-13 )
MSRDYNCTTDDQLAWGIPSISHAWGLWALLGVVTVLLLISLAALLSQWTRGRRRNQEGQGPLSGRSAEEVPLYGNLHYLQTGRLSQEPRSEEQDPPSSGGLARGAEEAMCYTSLQLRPAQGRIPSSGNPIKYCEVVLDSEPKPQAPGPEPELYASVCAQTRRGRASFPDQAYANSQPAPS
Atome Classification :
(20 SA)
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.........10...----------.--....20........30........40........50....---....60........70........80....---....90.......--.100.......110---...-....120.......130---.....-....140..---.....150....-...160.......170.......180----------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSRDYNCTTDDQLA----------W--GIP
S
I
S
H
A
W
G
L
W
A
L
L
G
V
V
T
V
L
L
L
I
S
L
A
A
L
L
S
Q
W
T
RGRRRN---QEGQGPLSGRSAEEV
P
L
YG
N
L
H
Y
L
QTGRLS---QEPRSEEQDPPSS--GGLARG
A
E
E
A
M
C
Y
T
---
S
L
Q
-LRPAQGRIPSSGNP
I
-----
K
Y
C
E
V
-
V
LDSEPKPQ---APGP
E
P
E
L
Y
A
S
V
-
C
A
Q
TRRGRASFPDQAYANSQPAPS------------------------
36
Fugue
56.44
18%
19
- C6 -
-
1WYK
2
POLS_SINDO
A:
[1-152]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
R
L
F
D
V
K
N
E
D
G
------------------------------
D
V
I
G
H
A
L
A
M
E
G
K
V
M
K
P
L
H
V
K
G
T
I
D
H
-------
P
V
L
S
K
L
K
F
T
K
S
S
A
Y
D
----
M
E
F
A
Q
L
P
---
V
N
M
R
S
E
A
F
T
Y
T
S
E
HP
E
G
F
Y
N
W
H
H
G
A
V
Q
Y
S
GG-
R
F
T
-
I
P
R
G
V
G
G
R
G
D
S
G
R
P
I
M
D
NSG
R
V
V
A
I
-
V
L
G
G
A
D
E
---------
G
T
R
T
A
L
S
V
-
V
T
W
N
S
K
G
K
----
T
I
K
T
T
P
E
G
T
E
E
W
------------------------
34
Fugue
54.45
18%
10
- C7 -
-
5UAO
1
?
A:
[21-539]
PADDDPGAIR
T
V
G
V
I
G
GG
T
A
G
Y
L
T
A
L
A
L
K
A
K
RPWLD
V
A
L
V
E
S
ADIPIIGVGEATV
S
Y
M
V
M
F
L
H
HYLGID
P
A
E
F
Y
Q
H
VR
P
T
W
K
L
G
I
R
F
EWGSRPE
G
F
V
A
P
FDWGTGSVG
L
V
G
S
L
R
E
TGNVNEAT
L
Q
A
M
L
M
T
E
DRVPVYRGEG
G
H
V
S
LMKY
L
P
F
A
Y
H
M
D
N
A
R
L
V
R
Y
L
T
E
L
A
A
R
R
G
V
R
H
V
D
A
T
V
AEVRLDGPDHVG
G
L
I
T
TD
G
R
R
L
H
Y
D
F
Y
V
D
CTGFRSLLLEKALGI
P
F
E
S
YASSLFTD
A
A
V
T
G
T
L
A
HGGHLKP
Y
T
T
A
T
T
M
NA
G
W
C
W
T
I
P
T
PE
S
D
H
L
G
Y
V
F
S
SAAID
P
D
D
A
A
A
E
M
A
R
R
F
P
G
V
T
R
E
A
L
V
R
F
R
S
G
R
H
REA
W
RG
N
V
M
A
V
G
N
S
Y
A
F
V
E
P
L
E
S
S
G
L
L
M
I
A
T
A
V
Q
I
L
V
S
L
L
P
S
S
R
R
D
PLP
S
D
A
A
N
Q
A
L
A
H
R
W
D
A
I
R
W
F
L
S
I
H
Y
R
F
N
G
R
L
D
T
P
F
W
K
E
A
R
A
E
T
D
I
S
G
I
--
E
P
L
L
R
L
F
A
A
G
A
P
L
T
GRD
S
F
T
-
R
Y
L
A
D
G
A
A
P
L
F
Y
G
-
L
-----
E
G
V
D
T
-
L
L
L
G
Q
E
V
P
A
RLL
P
P
R
E
P
P
E
Q
W
R
A
R
-
A
A
A
A
R
S
L
A
S
R
G
L
R
Q
S
E
A
L
D
A
Y
A
A
D
P
C
L
N
A
E
L
L
SDSDSWAG
E
R
V
A
V
R
A
G
9
PsiBlast_PDB
47.88
31%
-9
- C7 -
-
1UZJ
-
FBN1_HUMAN
A:
[51-108]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
---
I
R
P
R
G
D
N
G
D
T
A
C
S
--
N
E
I
G
V
G
V
S
K
A
S
C
C
C
---
S
L
-------
G
K
--
A
W
G
T
P
C
-----
E
M
C
P
A
-
V
N
T
S
E
Y
K
I
L
---
C
P
G
G
E
--------------------------------------------------------
37
Fugue
45.91
11%
101
* C6 *
-
4D0Q
9
HYSA_STRPN
A:
[1-161]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MQNLV
E
N
G
D
F
G
Q
T
E
D
G
S
S
P
----------
W
--
T
G
S
K
A
Q
G
-
W
S
A
W
V
D
Q
K
N
S
A
D
------
A
S
T
R
V
I
E
A
K
D
G
A
I
T
---
I
S
S
H
E
K
L
R
A
A
L
H
R
M
V
P
I
E
A
K
K
K
Y
K
L
R
F
K
I
K
---
T
D
N
K
I
G
-------------------
I
A
K
V
---
R
I
I
-
E
E
S
G
K
D
K
R
L
W
N
S
A
T
T
-----
S
G
T
K
D
-
W
Q
T
I
E
A
D
Y
S
---
P
T
L
D
V
D
K
I
K
L
E
L
-
F
Y
E
T
G
T
G
T
V
S
F
K
D
I
E
L
V
E
V
A
D
Q
L
S
------------------------
7
PsiBlast_PDB
42.13
33%
-7
- C7 -
-
1ODL
1
?
A:
[102-137]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-
L
I
V
A
Q
G
A
V
P
L
D
G
T
T
R
-----
Q
Y
L
E
-------
G
R
P
Y
---
A
P
V
P
D
P
E
V
F
R
A
L
-------------------------------------------------
6
PsiBlast_PDB
41.92
33%
-5
- C7 -
-
1ODK
1
?
A:
[102-143]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-
L
I
V
A
Q
G
A
V
P
L
D
G
T
T
R
-----
Q
Y
L
E
-------
G
R
P
Y
---
A
P
V
P
D
P
E
V
F
R
A
L
-------------------------------------------------
8
PsiBlast_PDB
41.82
33%
-9
- C7 -
-
1ODJ
-
?
A:
[102-137]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-
L
I
V
A
Q
G
A
V
P
L
D
G
T
T
R
-----
Q
Y
L
E
-------
G
R
P
Y
---
A
P
V
P
D
P
E
V
F
R
A
L
-------------------------------------------------
1
PsiBlast_PDB
40.20
37%
28
- C5 -
-
5U89
1
?
A:
[315-397]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
T
E
T
T
I
W
S
---
T
M
S
P
L
-------
P
S
I
G
R
P
I
-----
W
N
T
Q
V
Y
V
L
D
E
Q
L
Q
P
V
---
P
P
G
V
V
G
E
L
Y
I
A
--------------------------------------------------
5
PsiBlast_PDB
40.18
33%
7
- C7 -
-
1ODI
-
?
A:
[102-137]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-
L
I
V
A
Q
G
A
V
P
L
D
G
T
T
R
-----
Q
Y
L
E
-------
G
R
P
Y
---
A
P
V
P
D
P
E
V
F
R
A
L
-------------------------------------------------
18
HHSearch
38.17
21%
-512
- C7 -
-
3S3B
-
COX2_THET8
B:
[14-32]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
W
L
A
F
S
L
A
M
L
F
V
F
I
A
L
I
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
37.69
27%
5
- C7 -
-
3AGZ
-
DNJB1_HUMAN
A:
[6-59]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
K
K
Q
D
P
P
V
T
--
H
D
L
R
V
S
L
E
E
I
Y
S
G
C
---
T
K
K
-
M
K
I
S
H
K
R
L
N
P
D
G
K
S
I
-----
R
N
E
D
K
-
I
L
T
I
E
V
K
------------------------------------------------------------------
38
Fugue
35.72
9%
16
- C6 -
-
1I50
-
RPB9_YEAST
I:
[1-122]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
T
T
F
R
F
C
R
D
C
N
N
M
L
--------------------------------------------------------
Y
P
R
E
D
K
E
N
N
R
L
L
F
E
C
R
T
C
S
Y
V
E
E
A
G
S
P
L
V
Y
---
R
H
E
L
I
T
N
I
G
E
T
A
G
--
V
V
Q
D
I
G
S
D
P
----------
T
-
L
P
R
S
D
R
E
C
P
K
C
H
S
R
---------
E
N
-
V
F
F
Q
S
Q
Q
R
R
---
K
D
T
S
M
V
L
F
F
V
C
L
S
C
S
H
I
F
T
S
D
Q
K
-------
N
K
R
T
Q
F
S
------------------------
2
PsiBlast_PDB
33.82
43%
-223
- C8 -
-
5H9X
-
?
A:
[150-181]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
D
D
Q
I
Y
----------
W
--
G
V
I
G
I
N
P
V
N
G
K
W
S
Y
L
D
L
A
G
R
L
L
P
I
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
Fugue
33.45
12%
-215
* C7 *
-
2L9U
-
ERBB3_HUMAN
A:
[637-676]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
G
R
T
H
L
T
M
A
L
T
V
I
A
G
L
V
V
I
F
M
M
L
G
G
T
F
L
Y
W
R
G
R
R
H
H
H
H
H
---
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
32.66
43%
-215
- C8 -
-
5H9Y
-
?
A:
[150-181]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
D
D
Q
I
Y
----------
W
--
G
V
I
G
I
N
P
V
N
G
K
W
S
Y
L
D
L
A
G
R
L
L
P
I
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
Fugue
31.69
21%
-101
* C8 *
-
4QIW
-
RPOP_THEKO
P:
[8-49]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
A
K
C
G
K
---
E
V
E
-
L
D
L
A
T
A
R
----
E
V
R
C
-----
P
Y
C
G
S
-
K
I
L
Y
K
P
R
P
R
---
V
A
R
R
V
K
A
I
-----------------------------------------------------
16
HHSearch
31.15
18%
-275
- C7 -
-
1Z8Y
-
?
J:
[5-32]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
L
A
V
A
S
A
T
V
A
M
M
I
G
V
T
V
A
V
L
C
A
C
L
A
R
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
HHSearch
30.89
29%
-
- C2 -
-
2M20
-
EGFR_HUMAN
A:
[25-31]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
F
I
R
R
R
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
Fugue
30.08
43%
65
- C7 -
-
1RIJ
-
?
A:
[1-23]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
Q
E
L
L
G
Q
W
L
K
D
G
----------
G
P
S
S
G
R
P
P
P
S
----------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
28.80
14%
-44
- C7 -
-
2P7T
1
KCSA_STRLI
C:
[72-92]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
V
M
V
A
G
I
T
S
F
G
L
V
T
A
A
L
A
T
W
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------