@TOME V2.3
(Mar 2018)
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : THMS1_MOUSE: (2018-07-13 )
MALSLEEFVYSLDLRTLPRVLEIQSGIYFEGSVYEMFGNECCLSTGEVIKITGLKIKKMMAEICEGAIGGCESQKPFELPMNFPGLFKVMADKTPYLSIEEITRTVNIGPSRLGHPCFYHLKDIKLENLIIKQGEPIRFNSVEEINGETLVNCGVVRNHQSHSFTLPLSQEGEFYECEDEHIYTLKEIVEWKIPKNRTRTVKLTDFSNKWDSTNPFPEDFYGTLILKPVYEIQGVLKFQKDIVRILPSLDVEVKDITDSYDANWFLQLLSTDDLFEMTSKEFPVVAEVVEISQGNHLPQSILQREKTIVIHKKYQASRILASEIRSNFPKRHFLIPISYKGKFKRRPREFPTAYDLQIAKSRKETLHVVATKAFHTLHKELSPVSVGDQFLVHHSETTEVVFEGTRKVNVLTCEKVLNKTREDAQLPLYMEGGFVEVIHDKKQYQISELCTQFCWPFNVKVAVRDLSIKDDILAATPGLQLEEDITDSYLLISDFANPEECWEIPMSRLNMTVRLVNGSSLPADAGLLQVRSFVEEITEEQYYMMRRYESSLSHPPPRPPKHPSAEEMKLTLLSLAEERTINLPKSLKSHHVDRPKKLPSDESGQDSRAPVGFQNDVADVERQKSKHGPLQPQAPL
Atome Classification :
(20 SA)
.........10--..--------.......20.......---.30-.------....-...40........50.--------....-..-----.60.......-------.70...-----.....80..------...-...90-........100.......110.......---120.----......130.......--140.......--150...---....160.---.-----.....170.....----------.--.180.......190.-......200...-------....210--...----------....220...-....230-------.---......--------..240.--------...----------...250..---....-.260........270........280..-------.....290..-----------------------...------.---.300...---------....310.......320.......330.......340....-...350......-.360.......370.-......380...-----....390.----......-----400....------------...410........420.......430.-----.-...-------..440.........450----------------------------........460......----.470.....-----------.--..480-..--.-....490----....-------...500--..--.-.....-510..-------....------------------------------------------.520.---.....---------.530....-------...----------540......-----.550----....-----------.....560.......--570------------.......580.......590.......600.......610.......620.......630----.....--------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MAL
S
L
E
E
F
V
Y
---
S
L
--------
D
L
R
T
L
P
R
V
L
E
IQS
G
I
Y
---FE
G
-
S
------
V
Y
E
M
-FG
N
E
CCLSTG
E
V
I
K
IT--------G
L
K
I
-
K
K
-----
M
M
A
E
I
C
E
G
AI-------GGCESQ-----K
P
F
ELPMN
F
------
P
G
L
-
F
K
V
MA-DKTP
Y
L
S
I
E
E
I
T
R
TVNIGPSRLGHPC
F
Y
---
H
L
K
D----
I
K
L
E
N
L
I
IKQGEPIRF--N
S
V
E
EING
E
T
--
L
V
N
C
G
V
---VRNHQSH
S
---
F
-----
T
LPLSQEG
E
F
Y
EC----------E--D
E
H
I
Y
T
L
K
E
I
V
E
WKI-PKNR
T
R
T
V
K
LTD-------FSNKWDS--TNP----------F
P
E
D
F
Y
G
T
L
I
-
L
K
P
V
Y
---------
E
---
I
Q
G
V
L
K
--------
F
Q
K
D
I
V
--------
R
IL----------PSL
D
V
E
V
K---DITD-SY-DA
N
W
F
L
Q
LLST-
D
D
L
F
E
M
T
SKEF
P
V
-------
V
A
E
V
V
E
ISQG-----------------------NHL------
P
---
Q
S
I
L
QRE---------
K
T
I
V
I
H
KKY
Q
A
S
R
I
L
A
S
E
I
R
SNFPK
R
H
F
L
I
P
ISYKGKFKRR-PREFPT
A
Y
D
L
Q
I
-
A
KSRK
E
T
L
H
V
V
A
T
K
A
-
F
H
T
L
H
K
ELSPVS-----VG
D
Q
F
L
V
H----HSET
T
E
-----
V
V
F
EGT
R
------------
K
V
N
V
-
L
T
C
E
K
V
L
N
KTREDAQL
P
L
Y
MEG
G
-----
F
-
V
E
V
-------IHD--
K
K
QY
Q
I
S
E
L
C
T
-----------------------------QFCWPFN
V
K
V
A
V
R
DLSI----KD-
D
I
LAAT-----------P--GLQ
L
E
-
E
D--I-TD
S
Y
L
L
I
----SDFA-------
N
P
E
E
C
---
W
E
--
I
-
P
M
S
RL-
N
M
T
V
R
-------
L
VNG------------------------------------------SSLPA---
D
A
G
L
L
---------
Q
V
R
S
F
V
E
E
-------
I
T
E
----------
E
Q
Y
Y
M
M
R
R
Y
-----
E
S
------SLSH-----------PPPRPPKHP
S
A
E
E
M
K
--
L
T
L
------------
L
S
L
A
E
ERTINL
P
K
S
L
K
S
HHVDRPKKLPSDESGQDSRAPVGFQ
N
D
V
A
D
V
E
R
Q
KSKHGPLQ-----PQAPL--------------------------------------------------------------
31
Fugue
57.31
11%
21
* C6 *
-
1E3P
-
PNP_STRAT
A:
[20-734]
N
E
T
H
Y
A
E
A
V
I
---
D
---------
N
G
A
F
G
T
R
T
I
R
F
E
T
G
R
L
ARQ
A
A
G
-
S
------
A
V
A
Y
-
L
D
D
D
T
M
V
L
S
A
T
T
A
S
K
N
PKDQLDFF
P
L
T
V
-
D
V
-----
E
E
R
M
Y
A
A
G
K
I
PGSFFRR
E
G
R
P
S
E
-----
D
A
I
L
T
C
R
L
I
------
D
R
P
-
L
R
P
S
F
-
K
K
G
L
R
N
E
I
Q
V
V
A
T
I
M
A
L
N
P
D
H
L
Y
D
V
V
A
I
---
N
A
A
S
----
A
S
T
Q
L
A
G
L
P
F
S
G
P
I
G
G
--
V
R
V
A
L
I
R
G
Q
W
--
V
A
F
------
P
T
H
T
E
L
E
D
---
A
-----
V
F
D
M
V
V
A
G
R
V
----------------
L
E
D
G
D
V
A
I
M
M
V
E
A
E
A
-
T
E
K
T
I
Q
L
V
K
---------------
D
G
--
A
E
A
----------
P
T
E
E
V
V
A
A
G
L
-
D
A
A
K
P
---------
F
---
I
K
V
L
C
K
--------
A
Q
A
D
L
A
--------
A
K
A
AKPT
G
E
F
P
V
F
L
D
Y
Q
D
D
V
L
---
E
A
L
S
-
A
A
-
V
R
P
E
L
S
A
A
L
T
I
-
A
G
K
Q
D
R
E
A
E
L
D
R
V
-------
K
A
L
A
A
E
K
L
L
P
-----------------------
E
F
E
------
G
---
R
E
K
E
I
S
A
---------
A
Y
R
A
L
T
K
S
L
V
R
E
R
V
I
A
E
K
K
R
I
D
G
R
G
V
T
D
I
R
T
L
A
A
E
V
E
A
I
P
R
-
V
H
---
G
S
A
L
F
E
R
-
G
E
T
Q
I
L
G
V
T
T
L
N
M
L
R
-
M
E
Q
Q
L
D
T
L
S
P
-
V
-----
T
R
K
R
Y
M
H
N
----
Y
N
F
P
P
Y
-----
S
V
G
E
T
G
R
------------
V
G
S
P
-
K
R
R
E
I
G
H
G
A
L
A
E
R
A
I
V
P
V
L
P
T
R
E
EFP
Y
-
A
-
I
R
Q
-------
V
S
E
--
A
L
G
S
N
G
S
T
S
M
G
-----------------------------
S
V
C
A
S
T
-
M
S
L
L
N
A
G
V
P
L
----
K
A
-
P
V
A
G
I
A
-----------
M
--
G
L
I
S
Q
E
I
N
--
G
-
E
T
H
Y
V
A
L
----
T
D
I
L
-------
G
A
E
D
A
F
GD
M
D
--
F
-
K
V
A
G
T
-
K
E
F
V
T
-------
A
L
Q
L
------------------------------------------
D
T
K
L
D
---
G
I
P
A
S
---------
V
L
A
A
A
L
K
Q
-------
A
R
D
----------
A
R
L
H
I
L
D
V
M
-----
M
E
------
A
I
D
T
-----------
P
D
E
M
S
P
N
A
P
R
I
I
T
V
N
------------------
Q
I
Q
E
D
T
G
A
E
I
Y
I
G
A
A
D
G
P
A
A
E
A
G
S
V
V
K
T
T
F
G
A
F
V
S
L
L
D
G
L
L
H
-
L
G
V
G
Q
K
V
Q
V
E
I
A
E
I
D
-----
S
R
G
K
---------------------------------------------------------------
33
Fugue
54.84
16%
28
- C8 -
-
3UOX
1
OTEMO_PSEPU
A:
[6-545]
K
S
P
A
L
D
A
V
V
I
---
G
A
--------
G
V
T
G
I
Y
Q
A
F
L
I
N
Q
A
---------------------------------------------
G
M
K
V
-
L
G
-----
I
E
A
G
---
E
D
V
-------
G
G
T
W
Y
W
-----
N
------
R
Y
------
P
G
C
R
L
D
T
E
S
-
Y
A
Y
G
Y
F
A
L
K
G
I
---------------------
I
P
E
----
W
E
W
S
E
N
F
A
S
Q
P
E
M
L
R
Y
V
N
R
A
A
D
A
M
D
--------------
V
R
K
H
Y
R
F
N
TRV
T
-----
A
A
R
Y
V
E
N
D
R
L
W
E
V
----------
T
LD
N
E
E
V
V
T
C
R
F
L
I
S
A
T
G
-
P
L
S
A
P
D
I
K
G
I
D
S
-------
F
K
G
E
S
F
H
--
S
S
R
----------
W
P
T
D
A
E
G
A
P
K
G
V
D
F
T
G
---------
K
---
R
V
G
V
I
G
--------
T
G
A
T
G
V
--------
Q
I
I
----------
P
I
A
A
E
T
A
K
---
E
L
Y
V
-
F
Q
R
T
P
N
W
C
T
P
L
---------------------------------
G
-----------------------
N
-------------
S
P
M
S
K
E
---------
K
M
D
S
L
R
N
R
Y
P
T
I
L
E
Y
V
K
S
T
D
T
A
F
P
-------------
Y
H
R
D
-
P
R
K
---
G
T
D
V
S
E
-
S
E
R
D
A
F
F
E
E
L
Y
R
Q
P
G
-
Y
G
I
W
L
S
G
F
R
D
L
L
-----
L
N
K
E
S
N
K
F
----
L
A
D
F
V
A
-----
K
K
I
R
Q
R
V
------------
K
-
D
P
-
V
V
A
E
K
L
I
P
K
D
H
P
F
G
A
K
R
V
P
M
E
T
N
-----
Y
-
Y
E
T
YNRDN
V
H
L
V
D
--
I
R
E
A
P
I
Q
E
V
T
----------------------------------
P
E
G
I
K
T
A
D
A
A
Y
D
L
-----
D
-
V
I
I
Y
A
T
-----------
G
--
F
D
A
V
T
-
G
S
--
L
-
D
R
I
D
I
R
G
----
K
D
N
V
-------
R
L
I
D
A
---
W
A
--
E
G
P
S
T
Y
L
-
G
L
Q
A
R
GFPN
F
F
T
L
V
G
P
------------------------------------------
H
N
G
S
T
---
F
C
N
V
G
---------
V
C
G
G
L
Q
A
E
-------
W
V
L
----------
R
M
I
S
Y
M
K
D
N
-----
G
F
------
T
Y
S
E
-----------
P
T
Q
A
A
E
N
R
W
T
E
E
V
Y
A
--
D
F
S
------------
R
T
L
L
A
E
A
N
A
W
W
V
K
T
T
T
K
P
D
G
S
V
V
R
R
T
L
V
H
V
S
G
-----
G
P
E
Y
R
K
R
C
E
Q
V
A
Y
N
N
Y
N
G
F
E
L
A
------------------------------------------------------------------------
38
Fugue
54.00
16%
22
- C6 -
-
5L9W
1
APCD_AROAE
A:
[2-684]
A
I
P
T
L
E
Q
K
L
T
---
W
L
KPAPAS
S
R
E
L
D
L
A
A
Q
I
D
P
A
Q
F
E
I
G
---
F
Q
R
-
T
N
D
I
L
D
E
G
M
D
V
-
F
V
R
S
C
R
C
A
M
G
-
V
A
G
D
S
--------
L
V
A
I
-
M
T
-----
A
D
G
D
I
V
N
G
S
C
-------
G
T
-----------
Y
L
H
A
V
I
P
------
P
L
I
-
I
K
Y
I
L
-
E
T
Y
G
D
E
--------
I
R
D
G
D
L
W
F
A
N
D
A
V
Y
GGV
H
N
P
D
----
Q
M
V
C
M
P
V
Y
Y
E
G
K
L
V
A
W
--
T
A
A
L
V
H
T
T
E
T
GA
I
E
P
G
G
M
PVS
A
T
T
R
F
E
E
G
---
M
-----
N
L
P
P
M
R
I
G
E
N
F
K
L
----------
R
--
E
D
V
V
S
M
F
V
A
F
G
-------
L
R
A
P
S
M
I
A
V
D
-------
L
K
A
R
C
T
T
--
A
D
R
----------
V
R
T
R
I
I
E
L
C
E
-
R
E
G
A
D
---------
Y
---
V
T
G
L
F
R
K
M
L
Q
V
A
E
A
G
A
R
E
L
I
--------
E
Q
W
----------
P
D
G
K
Y
R
C
V
---
T
F
S
D
-
A
V
-
G
---
L
K
Q
G
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V
R
-
S
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Y
M
T
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E
K
K
G
D
R
M
-------
L
V
D
L
S
E
T
G
P
E
-----------------------
T
P
S
------
P
---
Y
N
A
-
H
P
Q
---------
A
A
I
A
H
F
S
N
Y
I
Y
E
Y
L
F
H
S
L
P
I
S
N
G
T
F
A
N
I
D
F
K
F
G
K
N
T
C
L
S
P
D
-
P
R
-
A
A
T
S
C
S
V
M
I
-
S
T
G
V
M
S
A
V
H
N
A
C
A
K
A
M
F
S
T
S
L
W
K
Q
S
G
A
S
-----
M
G
N
G
G
N
A
----------------
L
V
L
A
G
Q
N
------------
Q
W
G
S
-
S
F
A
D
M
L
A
Y
S
I
N
T
E
G
Q
G
A
R
P
T
E
D
G
MDAFG
F
-
P
W
C
-------
V
F
G
--
R
A
P
---
N
T
E
S
V
-----------------------------
E
N
E
F
P
L
L
V
P
L
S
N
H
W
K
D
S
C
G
H
G
K
Y
-
R
G
G
V
G
T
-----------
A
--
Q
V
W
V
A
-
H
H
--
V
-
P
E
L
Y
M
M
A
I
A
D
N
T
K
L
Q
-------
T
P
Q
P
L
---
F
G
G
Y
A
-
P
C
T
V
P
-
G
I
G
I
R
-------
N
A
N
I
------------------------------------------
K
E
L
M
A
E
GS
D
K
I
K
L
---------
D
V
E
T
L
L
A
E
RTID
G
K
Y
E
I
E
----------
F
Q
G
R
S
V
R
P
Y
-----
S
N
GEVVTF
A
F
S
C
G
G
T
G
Y
G
D----
P
L
D
R
D
P
K
S
V
E
V
D
L
L
K
GV
L
T
E
------------
Q
T
A
Q
N
I
Y
K
V
K
W
D
A
N
L
R
R
V
D
L
D
E
T
S
R
L
R
A
A
E
H
D
A
R
R
K
R
G
V
P
Y
E
Q
F
E
R
E
W
L
K
Q
R
P
D
D
E
I
L
K
YYGTW
P
D
A
K
V
AQPLLRA-------------------------------------------------------
34
Fugue
53.38
20%
29
* C8 *
-
4OPU
3
?
A:
[2-453]
----
M
K
E
L
K
Y
---
D
----------------
V
L
I
I
G
G
G
F
A
---
G
S
S
-
A
------
A
Y
Q
L
-
S
R
R
------
G
L
K
I
L
L
V
--------
D
----
S
K
-----
P
W
N
R
I
G
D
K
P
C
-------
G
D
A
V
S
K
-----
A
H
F
D
K
L
--------------------
G
M
P
Y
P
K
G
E
E
L
E
N
K
I
N
------------------
G
----
I
K
L
Y
S
P
D
M
Q
T
------------------------
V
W
---
T
V
N
H
E
G
F
E
---
L
-----
N
A
P
L
Y
N
Q
R
V
L
K
E
A
----------
Q
--
D
R
G
V
-------------------------------------------------------
E
I
W
D
L
T
T
A
-
M
K
P
I
F
---------
E
DGY
V
K
G
A
V
L
--------
F
N
R
R
------------------------------------------------------------
T
N
E
E
L
T
V
-------
Y
S
K
V
V
V
E
A
T
G
-------------------------------------------------------------------------------------
Y
S
R
S
F
R
S
K
L
P
P
E
L
P
I
T
E
D
L
D
D
-
K
D
A
D
V
A
Y
R
E
V
L
L
T
K
E
-
D
I
E
D
H
D
Y
L
R
I
F
I
-----------------
D
Q
E
T
S
P
G
G
Y
W
W
Y
F
P
K
G
K
N
------------
K
V
N
V
G
L
G
I
Q
G
G
M
G
Y
P
S
I
H
E
Y
Y
K
K
Y
L
D
K
Y
-----
A
-
P
D
V
-------
D
K
S
--
K
L
L
V
K
G
G
A
L
V
P
-----------------------------
T
R
-
R
P
L
Y
T
M
A
W
N
G
I
I
V
I
----
G
D
-
S
G
F
T
V
N
-----------
P
VH
G
G
G
K
G
-
S
A
--
M
-
I
S
G
Y
C
A
A
----
K
A
I
L
-------
S
A
F
E
T
---
G
D
--
F
-
S
A
S
G
L
W
D
M
N
I
C
-------
Y
V
N
E
------------------------------------------
Y
-
G
A
K
---
Q
A
S
L
D
---------
I
F
R
R
F
L
Q
K
-------
L
S
N
----------
D
D
I
N
Y
G
M
K
K
KIIK
E
E
D
------
L
L
E
A
-----------
S
E
K
G
D
L
H
L
S
V
A
D
K
A
M
--
R
V
I
------------
S
G
L
G
R
P
S
L
L
F
K
L
K
A
V
-
A
E
S
M
K
K
I
K
E
L
Y
L
N
Y
P
-
R
S
P
S
S
L
G
S
W
R
R
E
V
D
N
V
L
T
E
F
N
K
S
L
S
--------------------------------------------------------------------------
40
Fugue
51.07
18%
58
- C7 -
-
4P0G
3
MLTF_PSEAE
A:
[7-435]
A
P
T
A
L
E
R
V
Q
K
---
E
G
--------
V
L
R
V
I
T
R
N
---
S
P
A
T
Y
---
F
Q
D
-
R
------
N
G
E
T
G
F
E
Y
E
L
A
K
R
F
A
E
R
L
G
V
---------
E
L
K
I
-
E
T
-----
A
D
---------------------------------
N
L
------
D
D
L
-
Y
A
Q
L
S
R
E
G
G
P
A
L
A
A
A
G
L
T
P
G
R
E
D
D
A
S
-----
V
R
Y
---
S
H
T
Y
----
L
D
V
T
P
Q
I
I
Y
R
N
G
Q
Q
R
P
--
T
R
P
E
D
L
V
G
K
R
--
I
----
M
---
V
L
K
G
S
S
H
A
---
E
-----
Q
L
A
E
L
K
K
Q
Y
P
-----------------------------
E
L
-
K
Y
E
E
S
D
A
V
E
V
V
D
-------
L
L
R
M
V
D
-----------------
V
G
D
I
D
L
T
L
V
-
D
S
N
E
L
---------
A
---
M
N
Q
V
Y
-------------------------
F
----------
P
N
----
V
R
---
V
A
F
D
-
F
G
-
E
A
R
G
L
A
W
A
L
P
G
-
G
D
D
D
S
L
M
N
E
V
N
A
F
-------
L
D
Q
A
K
K
E
G
L
L
-----------------------
Q
R
L
------
K
---
D
R
Y
Y
G
H
V
---------
D
V
L
----
G
Y
V
G
A
Y
T
F
A
Q
H
L
Q
Q
R
L
P
R
--------
Y
E
S
H
F
K
Q
S
-
G
K
Q
L
D
T
D
W
R
L
L
A
-
A
I
G
Y
Q
E
S
L
-------------------------------
W
Q
----
P
G
A
T
S
K
-----
T
G
V
R
G
L
M
------------
M
L
T
N
-
R
T
A
Q
A
M
G
V
S
N
R
L
D
P
K
Q
S
I
Q
G
G
S
K
-----
Y
-
F
V
Q
-------
I
R
S
--
E
L
P
E
S
I
K
E
------------------------------------
P
D
R
S
W
F
A
L
A
A
Y
N
I
----
G
G
-
A
H
L
E
D
A
-----------
R
--
K
M
A
E
K
-
E
G
--
L
-----------------------
N
P
N
K
-------------------------------------------------------------------------------------
W
L
---------
D
V
K
K
M
L
P
R
-------
L
A
Q
----------
K
Q
W
Y
A
K
T
R
Y
-----
G
-----------------------------
Y
A
R
G
G
E
T
V
--
H
F
V
------------
Q
N
V
R
R
Y
Y
D
I
L
T
-------
W
V
T
Q
P
Q
-----------------------------------------------------------------------------------------------------------
37
Fugue
44.66
15%
-5
* C7 *
-
5FUR
-
TAF2_HUMAN
I:
[27-975]
-
K
L
T
H
Q
V
V
C
I
NNI
N
F
--------
Q
R
K
S
V
V
G
F
V
E
L
T
I
F
P
T
---
V
A
N
L
N
------
R
I
K
L
-
N
S
K
Q
C
R
I
Y
R
V
R
I
N
D
L
E
--------
A
A
F
I
Y
N
E
-----
L
C
I
K
V
P
S
E
L
W
-------
K
H
V
D
E
L
-----
K
V
L
K
I
H
I
N
F
SLDQPK
G
G
L
-
H
F
V
V
P
-
S
V
E
G
--
S
M
A
E
R
G
A
H
V
F
S
C
G
Y
Q
N
S
T
R
F
W
F
---
P
C
V
D
----
S
Y
S
E
L
C
T
W
K
L
E
F
T
V
D
A
--
A
M
V
A
V
S
N
G
-
D
--
L
V
E
T
V
Y
---
T
H
D
M
R
K
K
T
---
F
-----
H
Y
M
L
T
I
P
T
A
A
S
N
I
SLAIGPFEIL
V
--
D
P
Y
M
H
E
V
T
H
F
C
L
P
Q
L
L
P
L
L
K
H
T
T
S
Y
L
H
E
-------
V
F
E
F
Y
E
E
IL
T
C
R
----------
Y
P
Y
S
C
F
K
T
V
F
-
I
D
E
A
Y
VEVAAYASM
S
---
I
F
S
T
N
L
--------
L
H
S
A
M
I
IDETPLTR
R
C
L
----------
A
Q
S
L
A
Q
Q
F
FGC
F
I
S
R
M
S
W
-
S
D
E
W
V
L
K
G
I
S
G
-
Y
I
Y
G
L
W
M
K
K
T
F
G
V
NEYRHWI
K
E
E
L
D
K
I
V
A
Y
ELKTGGVLLHPIFGGGKEKDNPA
S
H
L
HFSIKH
P
---
H
T
L
S
W
E
Y
---------
Y
S
M
F
Q
C
K
A
H
L
V
M
R
L
I
E
N
R
I
S
M
E
F
M
L
Q
V
F
N
K
L
L
S
L
A
S
T
A
S
S
Q
-
K
F
Q
S
H
M
W
S
Q
M
L
V
S
T
S
G
F
L
K
S
I
S
N
V
S
G
K
D
-
I
Q
P
L
I
K
Q
W
V
D
Q
S
GVVKF
Y
G
S
F
A
F
N
R
----
K
R
N
V
L
E
-----
L
E
I
K
Q
D
Y
TSPGTQKYVGPL
K
V
T
V
-
Q
E
L
D
G
S
F
N
H
T
L
Q
I
E
E
N
S
L
K
H
D
I
P
-----
C
-
H
S
K
-------
S
R
R
--
N
K
K
K
K
I
P
L
M
N
G
EEVDMDLSAMDADSPLLWIRIDPDMSVLR
K
V
E
F
E
Q
A
D
F
M
W
Q
Y
Q
L
R
Y
----
E
R
-
D
V
V
A
Q
Q
-----------
E
--
S
I
L
A
L
-
E
K
FP
T
-
P
A
S
R
L
A
L
----
T
D
I
L
-------
E
Q
E
Q
C
F--
Y
R
--
V
-
R
M
S
A
C
-
F
C
L
A
K
-------
I
A
N
S
MVSTWTGPPAMKSLFTRMFCCKSCPNIVKTNNFMSFQSYFLQ
K
T
M
P
V
---
A
M
A
L
L
RDVHNLCPK
E
V
L
T
F
I
L
D
-------
L
I
K
YNDNRKNKFS
D
N
Y
Y
R
A
E
M
I
-----
D
A
LAN---
S
V
T
P
AVSVNNEVRTL
D
N
L
N
P
D
V
R
L
I
L
E
E
I
T
--
R
F
L
NMEKLLPSYRHT
I
T
V
S
C
L
R
A
I
R
V
L
Q
K
N
G
H
V
P
S
D
P
A
L
F
K
S
Y
A
E
Y
G
H
F
V
D
I
R
I
A
A
L
E
A
V
V
D
Y
T
K
V
D
R
S
Y
E
E
L
Q
-----
W
L
L
N
M
IQNDPVPYVRHKILNMLTKNPPFTKNMESPLCNEALVDQLWKLMNSGTSHDWRLRCGAVDLY
21
HHSearch
36.66
32%
-239
- C5 -
-
1FGP
-
G3P_BPFD
A:
[30-48]
-------------------------------------
A
N
---
Y
E
G
-
C
------
L
W
N
A
-
T
G
V
V
V
C
--
T
G
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
35.15
27%
-137
* C4 *
-
1MOF
-
A:
[39-53]
-------------------------------------------
E
G
-
G
------
L
C
A
A
-
L
K
E
E
C
A
F
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
35.00
32%
11
- C4 -
-
5C19
-
TERA_HUMAN
A:
[173-257]
--------------------------------------------------------------
C
I
V
A
P
D
T
V
I
H
C
E
--------
G
E
P
I
-
K
R
E
DEEE
S
L
N
E
V
G
Y
D
D
I
-------
G
G
C
R
K
Q
L
A
Q
I
K
E
M
V
E
L
P
L
R
H
------
P
A
L
-
F
K
A
I
G
-
V
K
P
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
Fugue
34.48
20%
-123
- C2 -
-
1WF9
-
NPL41_ARATH
A:
[1-107]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
S
G
S
S
G
T
M
L
R
V
R
S
R
D
G
-----
L
-
E
R
V
-------
S
V
D
--
G
P
H
I
T
V
S
Q
L
K
T
-----------------------------
L
I
Q
D
Q
L
Q
I
P
I
H
N
Q
T
L
S
T
----
N
R
-
N
L
L
L
A
K
-----------
S
--
P
S
D
F
L
-
A
F
---------------
T
D
M
A
-------
D
P
N
L
----------
R
I
S
S
L
-
N
L
A
-----------
H
G
------------------------------------------
S
--------------------------------------------------
M
V
Y
L
A
Y
E
G
-----
E
R
------
T
I
R
G
-----------
S
G
P
S
S
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
34.07
32%
-5
- C4 -
-
4KOD
1
TERA_HUMAN
A:
[174-238]
--------------------------------------------------------------
C
I
V
A
P
D
T
V
I
H
C
E
--------
G
E
P
I
-
K
R
E
DEEE
S
L
N
E
V
G
Y
D
D
I
-------
G
G
C
R
K
Q
L
A
Q
I
K
E
M
V
E
L
P
L
R
H
------
P
A
L
-
F
K
A
I
G
-
V
K
P
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
33.51
32%
19
- C4 -
-
3CF1
2
TERA_MOUSE
A:
[174-263]
--------------------------------------------------------------
C
I
V
A
P
D
T
V
I
H
C
E
--------
G
E
P
I
-
K
R
EDEEE
S
L
N
E
V
G
Y
D
D
I
-------
G
G
C
R
K
Q
L
A
Q
I
K
E
M
V
E
L
P
L
R
H
------
P
A
L
-
F
K
A
I
G
-
V
K
P
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
33.44
32%
1
- C4 -
-
5C18
1
TERA_HUMAN
A:
[173-244]
--------------------------------------------------------------
C
I
V
A
P
D
T
V
I
H
C
E
--------
G
E
P
I
-
K
R
E
DEEE
S
L
N
E
V
G
Y
D
D
I
-------
G
G
C
R
K
Q
L
A
Q
I
K
E
M
V
E
L
P
L
R
H
------
P
A
L
-
F
K
A
I
G
-
V
K
P
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
Fugue
32.96
14%
20
- C8 -
-
1C3J
1
GSTB_BPT4
A:
[1-351]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
I
A
--------
I
I
N
----------
M
G
N
N
V
I
N
F
---
K
T
V
P
-
S
S
-
E
T
I
Y
L
F
K
V
I
S
E
M
G
L
N
V
D
I
I
S
L
K
N
G
V
-------
Y
T
K
S
F
D
E
V
D
V
-----------------------
N
D
Y
------
D
---
R
L
I
V
V
N
S
---------
N
----
L
A
I
L
S
A
Q
K
F
M
A
K
-----
Y
K
S
K
I
Y
Y
L
F
T
D
I
R
L
P
F
S
Q
S
-
A
Y
L
Y
-
T
E
E
E
L
L
I
-
K
S
P
I
K
V
I
S
Q
G
I
N
L
D
I
-
A
K
A
A
H
K
K
V
D
N
V
I
-----
E
F
E
Y
F
P
I
E
QYKI
H
M
N
D
F
Q
-----
L
S
K
P
T
K
K
------------
T
L
D
V
-
I
Y
G
G
S
F
R
S
G
Q
R
E
S
K
M
V
E
F
L
F
D
T
G
-----
L
N
I
E
F
-------
F
G
N
AR
E
K
Q
F
K
N
P
K
Y
P
W
-----------------------------
T
K
A
P
V
F
T
G
K
I
P
M
N
M
V
S
E
----
K
N
S
Q
A
I
A
A
L
I
I
G
D
KNYNDNF
I
--
T
L
R
V
W
-
E
T
--
M
A
S
D
A
V
M
L
I
----
D
E
E
F
DTKHRII
N
D
A
R
F
---
Y
V
--
N
-
N
R
A
E
L
-
I
D
R
V
N
-------
E
L
K
H
------------------------------------------
S
D
V
L
R
---
K
E
M
L
S
---------
I
Q
H
D
I
L
N
K
-------
T
R
A
----------
K
K
A
E
W
Q
D
A
F
-----
K
K
------
A
I
D
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
32.55
32%
50
- C4 -
-
5DYI
1
TERA_HUMAN
A:
[174-238]
--------------------------------------------------------------
C
I
V
A
P
D
T
V
I
H
C
E
--------
G
E
P
I
-
K
R
E
DEEE
S
L
N
E
V
G
Y
D
D
I
-------
G
G
C
R
K
Q
L
A
Q
I
K
E
M
V
E
L
P
L
R
H
------
P
A
L
-
F
K
A
I
G
-
V
K
P
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
31.86
32%
38
- C4 -
-
5FTM
1
TERA_HUMAN
A:
[174-258]
--------------------------------------------------------------
C
I
V
A
P
D
T
V
I
H
C
E
--------
G
E
P
I
-
K
R
EDEEE
S
L
N
E
V
G
Y
D
D
I
-------
G
G
C
R
K
Q
L
A
Q
I
K
E
M
V
E
L
P
L
R
H
------
P
A
L
-
F
K
A
I
G
-
V
K
P
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
Fugue
31.74
18%
14
- C3 -
-
5A8J
5
?
A:
[2-366]
----------------------------------------------------------------------------------------------------------------------------
A
T
V
S
V
S
L
------
K
S
S
-
T
N
L
A
F
-
T
G
K
P
-
T
Q
V
S
L
I
V
R
V
S
P
T
S
F
A
S
L
S
G
I
H
Y
V
---
V
M
I
D
NSPS
M
K
K
E
N
K
I
N
L
A
L
S
S
A
S
R
--
L
V
Q
D
I
I
P
G
N
F
--
I
S
I
Y
L
F
---
S
N
D
I
E
T
L
Y
---
E
G
E
S
G
K
Q
I
E
L
K
S
I
K
M
G
Y
T
-----------
T
--
N
L
H
K
A
I
T
K
V
L
E
K
F
K
S
-
S
E
I
P
V
K
I
I
L
L
S
D
GKPTDKR
Y
S
R
D
Y
E
S
--
L
Q
V
P
KN
V
Q
L
I
T
I
G
L
G
E
D
Y
N
E
A
I
M
-
K
I
L
A
D
---------
K
---
G
S
G
V
F
Y
--------
H
I
N
D
P
S
--------
Q
L
P
----------
T
T
L
V
E
Q
K
S
---
D
K
V
A
-
A
Y
-
N
L
T
L
N
F
S
E
G
L
E
-
V
I
N
Y
E
M
P
V
N
I
P
V
V
-------
D
K
D
V
N
V
Y
A
V
G
-----------------------
N
I
P
------
P
G
E
T
D
Y
T
L
K
V
T
G
N
Y
V
D
SVSN
K
N
I
E
I
D
E
S
L
V
I
K
R
A
P
D
D
E
V
R
S
N
F
D
-
R
T
V
I
N
E
V
S
Y
-
Y
M
L
L
R
Y
-
Y
G
N
L
I
S
E
G
K
S
E
E
-
A
T
R
V
V
Q
E
L
L
T
A
A
E
R
T
-
K
R
V
E
L
I
E
R
T
K
K
L
-----
V
N
D
-
P
K
V
D
----
L
S
E
V
T
K
-----
T
M
R
T
G
S
I
------------
E
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
31.40
32%
30
- C4 -
-
5FTL
1
TERA_HUMAN
A:
[174-258]
--------------------------------------------------------------
C
I
V
A
P
D
T
V
I
H
C
E
--------
G
E
P
I
-
K
R
E
DEEE
S
L
N
E
V
G
Y
D
D
I
-------
G
G
C
R
K
Q
L
A
Q
I
K
E
M
V
E
L
P
L
R
H
------
P
A
L
-
F
K
A
I
G
-
V
K
P
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
30.24
32%
58
- C4 -
-
3CF3
1
TERA_MOUSE
A:
[174-258]
--------------------------------------------------------------
C
I
V
A
P
D
T
V
I
H
C
E
--------
G
E
P
I
-
K
R
EDEEE
S
L
N
E
V
G
Y
D
D
I
-------
G
G
C
R
K
Q
L
A
Q
I
K
E
M
V
E
L
P
L
R
H
------
P
A
L
-
F
K
A
I
G
-
V
K
P
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
29.90
32%
64
- C4 -
-
5IFW
1
TERA_HUMAN
B:
[175-285]
--------------------------------------------------------------
C
I
V
A
P
D
T
V
I
H
C
E
--------
G
E
P
I
-
K
R
E
DEEE
S
L
N
E
V
G
Y
D
D
I
-------
G
G
C
R
K
Q
L
A
Q
I
K
E
M
V
E
L
P
L
R
H
------
P
A
L
-
F
K
A
I
G
-
V
K
P
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------