@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : 2A5G_HUMAN: (2018-07-12 )
MLTCNKAGSRMVVDAANSNGPFQPVVLLHIRDVPPADQEKLFIQKLRQCCVLFDFVSDPLSDLKWKEVKRAALSEMVEYITHNRNVITEPIYPEVVHMFAVNMFRTLPPSSNPTGAEFDPEEDEPTLEAAWPHLQLVYEFFLRFLESPDFQPNIAKKYIDQKFVLQLLELFDSEDPRERDFLKTTLHRIYGKFLGLRAYIRKQINNIFYRFIYETEHHNGIAELLEILGSIINGFALPLKEEHKIFLLKVLLPLHKVKSLSVYHPQLAYCVVQFLEKDSTLTEPVVMALLKYWPKTHSPKEVMFLNELEEILDVIEPSEFVKIMEPLFRQLAKCVSSPHFQVAERALYYWNNEYIMSLISDNAAKILPIMFPSLYRNSKTHWNKTIHGLIYNALKLFMEMNQKLFDDCTQQFKAEKLKEKLKMKEREEAWVKIENLAKANPQYTVYSQASTMSIPVAMETDGPLFEDVQMLRKTVKDEAHQAQKDPKKDRPLARRKSELPQDPHTKKALEAHCRADELASQDGR
Atome Classification :
(20 SA)
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200-.......210.......220.......230.......240.......250.......260.......270.......280......------.290.......300--.........310.......320.......330.......340.......350.......360.......370.......380........390.......400........410..--.....420....-...430.......440.......450.......460.......470.......480.......490.......500.......510.......520..------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLTCNKAG
S
R
M
V
V
D
AANSNGPF
Q
P
V
V
L
L
H
IRDVPP
A
D
Q
E
K
L
F
I
Q
K
L
R
Q
C
C
V
L
F
D
F
V
SD
P
L
S
D
L
K
W
K
E
V
K
R
A
A
L
S
E
M
V
E
Y
I
THNRNVITEPI
Y
P
E
V
V
H
M
F
A
V
N
M
F
RTLPPSSNPTGAEFDPEEDEP
T
L
EAAW
P
H
L
Q
L
V
Y
E
F
F
L
R
F
LESPDFQ
P
N
I
A
K
K
YI
D
Q
K
F
V
L
Q
L
L
E
L
FDSEDP
R
E
R
D
F
L
K
T
T
L
H
R
I
Y
G
K
F
L
G
L
R
A
Y
I
R
K
-
Q
I
N
N
I
F
Y
R
F
IYETEHHN
G
I
A
E
L
L
E
I
L
G
S
I
I
N
GFALPLKEE
H
K
I
F
L
L
K
V
L
L
P
L
H
K
VKSLSVYH
P
Q
L
A
Y
C
V
V
Q
F
L
EKDST
L
T
E
P
V
V
M
A
------
L
L
K
YWPKTHSP
K
----
E
V
M
F
L
N
E
L
E
E
I
L
D
VI
E
P
S
E
F
V
K
I
M
E
P
L
F
R
Q
L
A
K
C
VSSP
H
F
Q
V
A
E
R
A
L
Y
YW
N
N
E
Y
I
M
S
L
I
SDNA
A
K
I
L
P
I
M
F
P
S
L
YRNSKT-
H
W
N
K
T
I
H
G
L
I
Y
N
A
L
K
L
F
M
E
M
-
N
Q
K
L
F
D
D
C
T
Q
Q
F
K
A
--
E
K
L
K
E
K
LK
M
K
E
R
-
E
E
A
W
V
K
I
E
N
L
AKANP
Q
Y
T
V
Y
SQAS
T
M
S
I
P
V
A
METDG
P
L
F
E
D
V
Q
M
L
R
K
T
V
K
D
E
A
H
Q
AQKDPKKDR
P
L
A
R
R
K
SELPQDPH
T
K
K
A
L
E
A
HCR
A
D
E
L
ASQDGR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
Fugue
83.77
100%
-165
- C1 -
-
3FGA
1
2A5G_HUMAN
B:
[1-403]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
P
A
D
Q
E
K
L
F
I
Q
K
L
R
Q
C
C
V
L
F
D
F
V
S
D
P
L
S
D
L
K
W
K
E
V
K
R
A
A
L
S
E
M
V
E
Y
I
T
H
N
R
N
V
I
T
E
P
I
Y
P
E
V
V
H
M
F
A
V
N
M
F
R
T
L
P
P
S
S
N
P
T
G
A
E
F
D
P
E
E
D
E
P
T
L
E
A
A
W
P
H
L
Q
L
V
Y
E
F
F
L
R
F
L
E
S
P
D
F
Q
P
N
I
A
K
K
Y
I
D
Q
K
F
V
L
Q
L
L
E
L
F
D
S
E
D
P
R
E
R
D
F
L
K
T
T
L
H
R
I
Y
G
K
F
L
G
L
R
A
Y
I
R
K
-
Q
I
N
N
I
F
Y
R
F
I
Y
E
T
E
H
H
N
G
I
A
E
L
L
E
I
L
G
S
I
I
N
G
F
A
L
P
L
K
E
E
H
K
I
F
L
L
K
V
L
L
P
L
H
K
V
K
S
L
S
V
Y
H
P
Q
L
A
Y
C
V
V
Q
F
L
E
K
D
S
T
L
T
E
P
V
V
M
A
------
L
L
K
Y
W
P
K
T
H
S
P
K
----
E
V
M
F
L
N
E
L
E
E
I
L
D
V
I
E
P
S
E
F
V
K
I
M
E
P
L
F
R
Q
L
A
K
C
V
S
S
P
H
F
Q
V
A
E
R
A
L
Y
Y
W
N
N
E
Y
I
M
S
L
I
S
D
N
A
A
K
I
L
P
I
M
F
P
S
L
Y
R
N
S
K
T
-
H
W
N
K
T
I
H
G
L
I
Y
N
A
L
K
L
F
M
E
M
-
N
Q
K
L
F
D
D
C
T
Q
Q
F
K
A
--
E
K
L
K
E
K
L
K
M
K
E
R
-
E
E
A
W
V
K
I
E
N
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
83.54
100%
-165
- C1 -
-
3FGA
1
2A5G_HUMAN
B:
[1-403]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
P
A
D
Q
E
K
L
F
I
Q
K
L
R
Q
C
C
V
L
F
D
F
V
S
D
P
L
S
D
L
K
W
K
E
V
K
R
A
A
L
S
E
M
V
E
Y
I
T
H
N
R
N
V
I
T
E
P
I
Y
P
E
V
V
H
M
F
A
V
N
M
F
R
T
L
P
P
S
S
N
P
T
G
A
E
F
D
P
E
E
D
E
P
T
L
E
A
A
W
P
H
L
Q
L
V
Y
E
F
F
L
R
F
L
E
S
P
D
F
Q
P
N
I
A
K
K
Y
I
D
Q
K
F
V
L
Q
L
L
E
L
F
D
S
E
D
P
R
E
R
D
F
L
K
T
T
L
H
R
I
Y
G
K
F
L
G
L
R
A
Y
I
R
K
-
Q
I
N
N
I
F
Y
R
F
I
Y
E
T
E
H
H
N
G
I
A
E
L
L
E
I
L
G
S
I
I
N
G
F
A
L
P
L
K
E
E
H
K
I
F
L
L
K
V
L
L
P
L
H
K
V
K
S
L
S
V
Y
H
P
Q
L
A
Y
C
V
V
Q
F
L
E
K
D
S
T
L
T
E
P
V
V
M
A
------
L
L
K
Y
W
P
K
T
H
S
P
K
----
E
V
M
F
L
N
E
L
E
E
I
L
D
V
I
E
P
S
E
F
V
K
I
M
E
P
L
F
R
Q
L
A
K
C
V
S
S
P
H
F
Q
V
A
E
R
A
L
Y
Y
W
N
N
E
Y
I
M
S
L
I
S
D
N
A
A
K
I
L
P
I
M
F
P
S
L
Y
R
N
S
K
T
-
H
W
N
K
T
I
H
G
L
I
Y
N
A
L
K
L
F
M
E
M
-
N
Q
K
L
F
D
D
C
T
Q
Q
F
K
A
--
E
K
L
K
E
K
L
K
M
K
E
R
-
E
E
A
W
V
K
I
E
N
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
HHSearch
80.49
100%
-181
- C1 -
-
2NYL
-
2A5G_HUMAN
E:
[1-386]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
K
L
F
I
Q
K
L
R
Q
C
C
V
L
F
D
F
V
S
D
P
L
S
D
L
K
W
K
E
V
K
R
A
A
L
S
E
M
V
E
Y
I
T
H
N
R
N
V
I
T
E
P
I
Y
P
E
V
V
H
M
F
A
V
N
M
F
R
T
L
P
P
S
S
N
P
T
G
A
E
F
D
P
E
E
D
E
P
T
L
E
A
A
W
P
H
L
Q
L
V
Y
E
F
F
L
R
F
L
E
S
P
D
F
Q
P
N
I
A
K
K
Y
I
D
Q
K
F
V
L
Q
L
L
E
L
F
D
S
E
D
P
R
E
R
D
F
L
K
T
T
L
H
R
I
Y
G
K
F
L
G
L
R
A
Y
I
R
K
-
Q
I
N
N
I
F
Y
R
F
I
Y
E
T
E
H
H
N
G
I
A
E
L
L
E
I
L
G
S
I
I
N
G
F
A
L
P
L
K
E
E
H
K
I
F
L
L
K
V
L
L
P
L
H
K
V
K
S
L
S
V
Y
H
P
Q
L
A
Y
C
V
V
Q
F
L
E
K
D
S
T
L
T
E
P
V
V
M
A
------
L
L
K
Y
W
P
K
T
H
S
P
K
----
E
V
M
F
L
N
E
L
E
E
I
L
D
V
I
E
P
S
E
F
V
K
I
M
E
P
L
F
R
Q
L
A
K
C
V
S
S
P
H
F
Q
V
A
E
R
A
L
Y
Y
W
N
N
E
Y
I
M
S
L
I
S
D
N
A
A
K
I
L
P
I
M
F
P
S
L
Y
R
N
S
K
T
-
H
W
N
K
T
I
H
G
L
I
Y
N
A
L
K
L
F
M
E
M
-
N
Q
K
L
F
D
D
C
T
Q
Q
F
K
A
--
E
K
L
K
E
K
L
K
M
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
80.46
100%
-175
- C1 -
-
2NPP
-
2A5G_HUMAN
B:
[38-425]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
K
L
F
I
Q
K
L
R
Q
C
C
V
L
F
D
F
V
S
D
P
L
S
D
L
K
W
K
E
V
K
R
A
A
L
S
E
M
V
E
Y
I
T
H
N
R
N
V
I
T
E
P
I
Y
P
E
V
V
H
M
F
A
V
N
M
F
R
T
L
P
P
S
S
N
P
T
G
A
E
F
D
P
E
E
D
E
P
T
L
E
A
A
W
P
H
L
Q
L
V
Y
E
F
F
L
R
F
L
E
S
P
D
F
Q
P
N
I
A
K
K
Y
I
D
Q
K
F
V
L
Q
L
L
E
L
F
D
S
E
D
P
R
E
R
D
F
L
K
T
T
L
H
R
I
Y
G
K
F
L
G
L
R
A
Y
I
R
K
-
Q
I
N
N
I
F
Y
R
F
I
Y
E
T
E
H
H
N
G
I
A
E
L
L
E
I
L
G
S
I
I
N
G
F
A
L
P
L
K
E
E
H
K
I
F
L
L
K
V
L
L
P
L
H
K
V
K
S
L
S
V
Y
H
P
Q
L
A
Y
C
V
V
Q
F
L
E
K
D
S
T
L
T
E
P
V
V
M
A
------
L
L
K
Y
W
P
K
T
H
S
P
K
----
E
V
M
F
L
N
E
L
E
E
I
L
D
V
I
E
P
S
E
F
V
K
I
M
E
P
L
F
R
Q
L
A
K
C
V
S
S
P
H
F
Q
V
A
E
R
A
L
Y
Y
W
N
N
E
Y
I
M
S
L
I
S
D
N
A
A
K
I
L
P
I
M
F
P
S
L
Y
R
N
S
K
T
-
H
W
N
K
T
I
H
G
L
I
Y
N
A
L
K
L
F
M
E
M
-
N
Q
K
L
F
D
D
C
T
Q
Q
F
K
A
--
E
K
L
K
E
K
L
K
M
K
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
78.44
97%
-178
- C1 -
-
2NYM
-
2A5G_HUMAN
B:
[1-377]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
K
L
F
I
Q
K
L
R
Q
C
C
V
L
F
D
F
V
S
D
P
L
S
D
L
K
W
K
E
V
K
R
A
A
L
S
E
M
V
E
Y
I
T
H
N
R
N
V
I
T
E
P
I
Y
P
E
V
V
H
M
F
A
V
N
M
F
R
T
L
P
P
S
S
N
P
T
G
A
E
F
D
P
E
E
D
E
P
T
L
E
A
A
W
P
H
L
Q
L
V
Y
E
F
F
L
R
F
L
E
S
P
D
F
Q
P
N
I
A
K
K
Y
I
D
Q
K
F
V
L
Q
L
L
E
L
F
D
S
E
D
P
R
E
R
D
F
L
K
T
T
L
H
R
I
Y
G
K
F
L
G
L
R
A
Y
I
R
K
-
Q
I
N
N
I
F
Y
R
F
I
Y
E
T
E
H
H
N
G
I
A
E
L
L
E
I
L
G
S
I
I
N
G
F
A
L
P
L
K
E
E
H
K
I
F
L
L
K
V
L
L
P
L
H
K
V
K
S
L
S
V
Y
H
P
Q
L
A
Y
C
V
V
Q
F
L
E
K
D
S
T
L
T
E
P
V
V
M
A
------
L
L
K
Y
W
P
K
T
H
S
P
K
----
E
V
M
F
L
N
E
L
E
E
I
L
D
V
I
E
P
S
E
F
V
K
I
M
E
P
L
F
R
Q
L
A
K
C
V
S
S
P
H
F
Q
V
A
E
R
A
L
Y
Y
W
N
N
E
Y
I
M
S
L
I
S
D
N
A
A
K
I
L
P
I
M
F
P
S
L
Y
R
N
S
K
T
-
H
W
N
K
T
I
H
G
L
I
Y
N
A
L
K
L
F
M
E
M
-
N
Q
K
L
F
D
D
C
T
Q
Q
F
K
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
77.73
97%
-184
- C1 -
-
2NYL
-
2A5G_HUMAN
B:
[1-377]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
K
L
F
I
Q
K
L
R
Q
C
C
V
L
F
D
F
V
S
D
P
L
S
D
L
K
W
K
E
V
K
R
A
A
L
S
E
M
V
E
Y
I
T
H
N
R
N
V
I
T
E
P
I
Y
P
E
V
V
H
M
F
A
V
N
M
F
R
T
L
P
P
S
S
N
P
T
G
A
E
F
D
P
E
E
D
E
P
T
L
E
A
A
W
P
H
L
Q
L
V
Y
E
F
F
L
R
F
L
E
S
P
D
F
Q
P
N
I
A
K
K
Y
I
D
Q
K
F
V
L
Q
L
L
E
L
F
D
S
E
D
P
R
E
R
D
F
L
K
T
T
L
H
R
I
Y
G
K
F
L
G
L
R
A
Y
I
R
K
-
Q
I
N
N
I
F
Y
R
F
I
Y
E
T
E
H
H
N
G
I
A
E
L
L
E
I
L
G
S
I
I
N
G
F
A
L
P
L
K
E
E
H
K
I
F
L
L
K
V
L
L
P
L
H
K
V
K
S
L
S
V
Y
H
P
Q
L
A
Y
C
V
V
Q
F
L
E
K
D
S
T
L
T
E
P
V
V
M
A
------
L
L
K
Y
W
P
K
T
H
S
P
K
----
E
V
M
F
L
N
E
L
E
E
I
L
D
V
I
E
P
S
E
F
V
K
I
M
E
P
L
F
R
Q
L
A
K
C
V
S
S
P
H
F
Q
V
A
E
R
A
L
Y
Y
W
N
N
E
Y
I
M
S
L
I
S
D
N
A
A
K
I
L
P
I
M
F
P
S
L
Y
R
N
S
K
T
-
H
W
N
K
T
I
H
G
L
I
Y
N
A
L
K
L
F
M
E
M
-
N
Q
K
L
F
D
D
C
T
Q
Q
F
K
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
76.53
100%
-148
- C1 -
-
2IAE
-
2A5G_HUMAN
B:
[2-377]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
V
P
P
A
D
Q
E
K
L
F
I
Q
K
L
R
Q
C
C
V
L
F
D
F
V
S
D
P
L
S
D
L
K
W
K
E
V
K
R
A
A
L
S
E
M
V
E
Y
I
T
H
N
R
N
V
I
T
E
P
I
Y
P
E
V
V
H
M
F
A
V
N
M
F
R
T
L
P
P
S
S
N
P
T
G
A
E
F
D
P
E
E
D
E
P
T
L
E
A
A
W
P
H
L
Q
L
V
Y
E
F
F
L
R
F
L
E
S
P
D
F
Q
P
N
I
A
K
K
Y
I
D
Q
K
F
V
L
Q
L
L
E
L
F
D
S
E
D
P
R
E
R
D
F
L
K
T
T
L
H
R
I
Y
G
K
F
L
G
L
R
A
Y
I
R
K
-
Q
I
N
N
I
F
Y
R
F
I
Y
E
T
E
H
H
N
G
I
A
E
L
L
E
I
L
G
S
I
I
N
G
F
A
L
P
L
K
E
E
H
K
I
F
L
L
K
V
L
L
P
L
H
K
V
K
S
L
S
V
Y
H
P
Q
L
A
Y
C
V
V
Q
F
L
E
K
D
S
T
L
T
E
P
V
V
M
A
------
L
L
K
Y
W
P
K
T
H
S
P
K
----
E
V
M
F
L
N
E
L
E
E
I
L
D
V
I
E
P
S
E
F
V
K
I
M
E
P
L
F
R
Q
L
A
K
C
V
S
S
P
H
F
Q
V
A
E
R
A
L
Y
Y
W
N
N
E
Y
I
M
S
L
I
S
D
N
A
A
K
I
L
P
I
M
F
P
S
L
Y
R
N
S
K
T
-
H
W
N
K
T
I
H
G
L
I
Y
N
A
L
K
L
F
M
E
M
-
N
Q
K
L
F
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
76.50
100%
-182
- C1 -
-
5JJA
-
2A5G_HUMAN
A:
[2-347]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
D
V
P
P
A
D
Q
E
K
L
F
I
Q
K
L
R
Q
C
C
V
L
F
D
F
V
S
D
P
L
S
D
L
K
W
K
E
V
K
R
A
A
L
S
E
M
V
E
Y
I
T
H
N
R
N
V
I
T
E
P
I
Y
P
E
V
V
H
M
F
A
V
N
M
F
R
T
L
P
P
--------------
E
P
T
L
E
A
A
W
P
H
L
Q
L
V
Y
E
F
F
L
R
F
L
E
S
P
D
F
Q
P
N
I
A
K
K
Y
I
D
Q
K
F
V
L
Q
L
L
E
L
F
D
S
E
D
P
R
E
R
D
F
L
K
T
T
L
H
R
I
Y
G
K
F
L
G
L
R
A
Y
I
R
K
-
Q
I
N
N
I
F
Y
R
F
I
Y
E
T
E
H
H
N
G
I
A
E
L
L
E
I
L
G
S
I
I
N
G
F
A
L
P
L
K
E
E
H
K
I
F
L
L
K
V
L
L
P
L
H
K
V
K
S
L
S
V
Y
H
P
Q
L
A
Y
C
V
V
Q
F
L
E
K
D
S
T
L
T
E
P
V
V
M
A
------
L
L
K
Y
W
P
K
T
H
S
P
K
----
E
V
M
F
L
N
E
L
E
E
I
L
D
V
I
E
P
S
E
F
V
K
I
M
E
P
L
F
R
Q
L
A
K
C
V
S
S
P
H
F
Q
V
A
E
R
A
L
Y
Y
W
N
N
E
Y
I
M
S
L
I
S
D
N
A
A
K
I
L
P
I
M
F
P
S
L
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
HHSearch
76.02
100%
-178
- C1 -
-
5JJA
-
2A5G_HUMAN
B:
[2-348]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
D
V
P
P
A
D
Q
E
K
L
F
I
Q
K
L
R
Q
C
C
V
L
F
D
F
V
S
D
P
L
S
D
L
K
W
K
E
V
K
R
A
A
L
S
E
M
V
E
Y
I
T
H
N
R
N
V
I
T
E
P
I
Y
P
E
V
V
H
M
F
A
V
N
M
F
R
T
L
P
P
--------------
E
P
T
L
E
A
A
W
P
H
L
Q
L
V
Y
E
F
F
L
R
F
L
E
S
P
D
F
Q
P
N
I
A
K
K
Y
I
D
Q
K
F
V
L
Q
L
L
E
L
F
D
S
E
D
P
R
E
R
D
F
L
K
T
T
L
H
R
I
Y
G
K
F
L
G
L
R
A
Y
I
R
K
-
Q
I
N
N
I
F
Y
R
F
I
Y
E
T
E
H
H
N
G
I
A
E
L
L
E
I
L
G
S
I
I
N
G
F
A
L
P
L
K
E
E
H
K
I
F
L
L
K
V
L
L
P
L
H
K
V
K
S
L
S
V
Y
H
P
Q
L
A
Y
C
V
V
Q
F
L
E
K
D
S
T
L
T
E
P
V
V
M
A
------
L
L
K
Y
W
P
K
T
H
S
P
K
----
E
V
M
F
L
N
E
L
E
E
I
L
D
V
I
E
P
S
E
F
V
K
I
M
E
P
L
F
R
Q
L
A
K
C
V
S
S
P
H
F
Q
V
A
E
R
A
L
Y
Y
W
N
N
E
Y
I
M
S
L
I
S
D
N
A
A
K
I
L
P
I
M
F
P
S
L
Y
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
75.49
100%
-194
- C1 -
-
5SWF
-
2A5G_HUMAN
A:
[11-352]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
Q
E
K
L
F
I
Q
K
L
R
Q
C
C
V
L
F
D
F
V
S
D
P
L
S
D
L
K
W
K
E
V
K
R
A
A
L
S
E
M
V
E
Y
I
T
H
N
R
N
V
I
T
E
P
I
Y
P
E
V
V
H
M
F
A
V
N
M
F
R
T
L
P
-------------------
E
A
A
W
P
H
L
Q
L
V
Y
E
F
F
L
R
F
L
E
S
P
D
F
Q
P
N
I
A
K
K
Y
I
D
Q
K
F
V
L
Q
L
L
E
L
F
D
S
E
D
P
R
E
R
D
F
L
K
T
T
L
H
R
I
Y
G
K
F
L
G
L
R
A
Y
I
R
K
-
Q
I
N
N
I
F
Y
R
F
I
Y
E
T
E
H
H
N
G
I
A
E
L
L
E
I
L
G
S
I
I
N
G
F
A
L
P
L
K
E
E
H
K
I
F
L
L
K
V
L
L
P
L
H
K
V
K
S
L
S
V
Y
H
P
Q
L
A
Y
C
V
V
Q
F
L
E
K
D
S
T
L
T
E
P
V
V
M
A
------
L
L
K
Y
W
P
K
T
H
S
P
K
----
E
V
M
F
L
N
E
L
E
E
I
L
D
V
I
E
P
S
E
F
V
K
I
M
E
P
L
F
R
Q
L
A
K
C
V
S
S
P
H
F
Q
V
A
E
R
A
L
Y
Y
W
N
N
E
Y
I
M
S
L
I
S
D
N
A
A
K
I
L
P
I
M
F
P
S
L
Y
R
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
Fugue
75.15
98%
-188
- C1 -
-
2JAK
-
2A5G_HUMAN
A:
[30-372]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
D
V
P
A
D
Q
E
K
L
F
I
Q
K
L
R
Q
C
C
V
L
F
D
F
V
S
D
P
L
S
D
L
K
W
K
E
V
K
R
A
A
L
S
E
M
V
E
Y
I
T
H
N
R
N
V
I
T
E
P
I
Y
P
E
V
V
H
M
F
A
V
N
M
F
R
T
L
P
P
---------------
P
T
L
E
A
A
W
P
H
L
Q
L
V
Y
E
F
F
L
R
F
L
E
S
P
D
F
Q
P
N
I
A
K
K
Y
I
D
Q
K
F
V
L
Q
L
L
E
L
F
D
S
E
D
P
R
E
R
D
F
L
K
T
T
L
H
R
I
Y
G
K
F
L
G
L
R
A
Y
I
R
K
-
Q
I
N
N
I
F
Y
R
F
I
Y
E
T
E
H
H
N
G
I
A
E
L
L
E
I
L
G
S
I
I
N
G
F
A
L
P
L
K
E
E
H
K
I
F
L
L
K
V
L
L
P
L
H
K
V
K
S
L
S
V
Y
H
P
Q
L
A
Y
C
V
V
Q
F
L
E
K
D
S
T
L
T
E
P
V
V
M
A
------
L
L
K
Y
W
P
K
T
H
S
P
K
----
E
V
M
F
L
N
E
L
E
E
I
L
D
V
I
E
P
S
E
F
V
K
I
M
E
P
L
F
R
Q
L
A
K
C
V
S
S
P
H
F
Q
V
A
E
R
A
L
Y
Y
W
N
N
E
Y
I
M
S
L
I
S
D
N
A
A
K
I
L
P
I
M
F
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
HHSearch
75.06
99%
-189
- C1 -
-
2JAK
-
2A5G_HUMAN
A:
[30-372]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
D
V
P
-
A
D
Q
E
K
L
F
I
Q
K
L
R
Q
C
C
V
L
F
D
F
V
S
D
P
L
S
D
L
K
W
K
E
V
K
R
A
A
L
S
E
M
V
E
Y
I
T
H
N
R
N
V
I
T
E
P
I
Y
P
E
V
V
H
M
F
A
V
N
M
F
R
T
L
P
P
---------------
P
T
L
E
A
A
W
P
H
L
Q
L
V
Y
E
F
F
L
R
F
L
E
S
P
D
F
Q
P
N
I
A
K
K
Y
I
D
Q
K
F
V
L
Q
L
L
E
L
F
D
S
E
D
P
R
E
R
D
F
L
K
T
T
L
H
R
I
Y
G
K
F
L
G
L
R
A
Y
I
R
K
-
Q
I
N
N
I
F
Y
R
F
I
Y
E
T
E
H
H
N
G
I
A
E
L
L
E
I
L
G
S
I
I
N
G
F
A
L
P
L
K
E
E
H
K
I
F
L
L
K
V
L
L
P
L
H
K
V
K
S
L
S
V
Y
H
P
Q
L
A
Y
C
V
V
Q
F
L
E
K
D
S
T
L
T
E
P
V
V
M
A
------
L
L
K
Y
W
P
K
T
H
S
P
K
----
E
V
M
F
L
N
E
L
E
E
I
L
D
V
I
E
P
S
E
F
V
K
I
M
E
P
L
F
R
Q
L
A
K
C
V
S
S
P
H
F
Q
V
A
E
R
A
L
Y
Y
W
N
N
E
Y
I
M
S
L
I
S
D
N
A
A
K
I
L
P
I
M
F
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
74.90
98%
-189
- C1 -
-
2JAK
-
2A5G_HUMAN
A:
[30-372]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
D
V
P
-
A
D
Q
E
K
L
F
I
Q
K
L
R
Q
C
C
V
L
F
D
F
V
S
D
P
L
S
D
L
K
W
K
E
V
K
R
A
A
L
S
E
M
V
E
Y
I
T
H
N
R
N
V
I
T
E
P
I
Y
P
E
V
V
H
M
F
A
V
N
M
F
R
T
L
P
P
---------------
P
T
L
E
A
A
W
P
H
L
Q
L
V
Y
E
F
F
L
R
F
L
E
S
P
D
F
Q
P
N
I
A
K
K
Y
I
D
Q
K
F
V
L
Q
L
L
E
L
F
D
S
E
D
P
R
E
R
D
F
L
K
T
T
L
H
R
I
Y
G
K
F
L
G
L
R
A
Y
I
R
K
-
Q
I
N
N
I
F
Y
R
F
I
Y
E
T
E
H
H
N
G
I
A
E
L
L
E
I
L
G
S
I
I
N
G
F
A
L
P
L
K
E
E
H
K
I
F
L
L
K
V
L
L
P
L
H
K
V
K
S
L
S
V
Y
H
P
Q
L
A
Y
C
V
V
Q
F
L
E
K
D
S
T
L
T
E
P
V
V
M
A
------
L
L
K
Y
W
P
K
T
H
S
P
K
----
E
V
M
F
L
N
E
L
E
E
I
L
D
V
I
E
P
S
E
F
V
K
I
M
E
P
L
F
R
Q
L
A
K
C
V
S
S
P
H
F
Q
V
A
E
R
A
L
Y
Y
W
N
N
E
Y
I
M
S
L
I
S
D
N
A
A
K
I
L
P
I
M
F
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
74.65
100%
-198
- C1 -
-
5SW9
-
2A5G_HUMAN
A:
[11-352]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
Q
E
K
L
F
I
Q
K
L
R
Q
C
C
V
L
F
D
F
V
S
D
P
L
S
D
L
K
W
K
E
V
K
R
A
A
L
S
E
M
V
E
Y
I
T
H
N
R
N
V
I
T
E
P
I
Y
P
E
V
V
H
M
F
A
V
N
M
F
R
T
L
P
P
------------------
E
A
A
W
P
H
L
Q
L
V
Y
E
F
F
L
R
F
L
E
S
P
D
F
Q
P
N
I
A
K
K
Y
I
D
Q
K
F
V
L
Q
L
L
E
L
F
D
S
E
D
P
R
E
R
D
F
L
K
T
T
L
H
R
I
Y
G
K
F
L
G
L
R
A
Y
I
R
K
-
Q
I
N
N
I
F
Y
R
F
I
Y
E
T
E
H
H
N
G
I
A
E
L
L
E
I
L
G
S
I
I
N
G
F
A
L
P
L
K
E
E
H
K
I
F
L
L
K
V
L
L
P
L
H
K
V
K
S
L
S
V
Y
H
P
Q
L
A
Y
C
V
V
Q
F
L
E
K
D
S
T
L
T
E
P
V
V
M
A
------
L
L
K
Y
W
P
K
T
H
S
P
K
----
E
V
M
F
L
N
E
L
E
E
I
L
D
V
I
E
P
S
E
F
V
K
I
M
E
P
L
F
R
Q
L
A
K
C
V
S
S
P
H
F
Q
V
A
E
R
A
L
Y
Y
W
N
N
E
Y
I
M
S
L
I
S
D
N
A
A
K
I
L
P
I
M
F
P
S
L
Y
R
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
74.49
100%
-194
- C1 -
-
5K6S
-
2A5G_HUMAN
A:
[12-352]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
E
K
L
F
I
Q
K
L
R
Q
C
C
V
L
F
D
F
V
S
D
P
L
S
D
L
K
W
K
E
V
K
R
A
A
L
S
E
M
V
E
Y
I
T
H
N
R
N
V
I
T
E
P
I
Y
P
E
V
V
H
M
F
A
V
N
M
F
R
T
L
P
P
------------------
E
A
A
W
P
H
L
Q
L
V
Y
E
F
F
L
R
F
L
E
S
P
D
F
Q
P
N
I
A
K
K
Y
I
D
Q
K
F
V
L
Q
L
L
E
L
F
D
S
E
D
P
R
E
R
D
F
L
K
T
T
L
H
R
I
Y
G
K
F
L
G
L
R
A
Y
I
R
K
-
Q
I
N
N
I
F
Y
R
F
I
Y
E
T
E
H
H
N
G
I
A
E
L
L
E
I
L
G
S
I
I
N
G
F
A
L
P
L
K
E
E
H
K
I
F
L
L
K
V
L
L
P
L
H
K
V
K
S
L
S
V
Y
H
P
Q
L
A
Y
C
V
V
Q
F
L
E
K
D
S
T
L
T
E
P
V
V
M
A
------
L
L
K
Y
W
P
K
T
H
S
P
K
----
E
V
M
F
L
N
E
L
E
E
I
L
D
V
I
E
P
S
E
F
V
K
I
M
E
P
L
F
R
Q
L
A
K
C
V
S
S
P
H
F
Q
V
A
E
R
A
L
Y
Y
W
N
N
E
Y
I
M
S
L
I
S
D
N
A
A
K
I
L
P
I
M
F
P
S
L
Y
R
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
36.32
18%
-302
- C1 -
-
5XZX
-
IMA3_HUMAN
A:
[83-121]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
V
Q
S
N
A
V
P
L
F
L
R
L
L
H
S
P
H
Q
N
V
C
E
Q
A
V
W
A
L
G
N
I
I
G
D
G
P
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
Fugue
33.57
15%
9
- C1 -
-
3W3W
-
IMB3_YEAST
A:
[3-1077]
ALP
E
E
V
N
R
T
L
L
Q
I
V
Q
A
FASD
N
Q
I
R
S
V
A
E
K
A
L
S
EEWITENN
I
E
Y
L
L
T
F
L
A
E
Q
A
A
FSQD
T
T
V
A
A
L
S
A
V
L
F
R
K
L
A
L
K
A
PITHIR
K
E
V
L
A
Q
I
R
S
S
L
L
K
G
F
L
SERA
D
S
I
R
H
K
L
S
D
A
I
A
E
C
VQDDLPAW
P
E
L
L
Q
A
L
I
E
S
L
K
SGN
P
N
F
R
E
S
S
F
R
I
L
T
T
V
P
Y
L
I
T
A
VD
I
N
S
I
L
P
I
F
Q
S
G
F
T
DAS
D
N
V
K
I
A
A
V
T
A
F
V
G
Y
F
K
Q
L
P
K
S
E
W
S
K
L
G
I
L
L
P
S
L
L
N
S
L
P
R
F
L
D
D
G
K
D
D
A
L
A
S
V
F
E
S
L
I
E
L
V
E
L
A
------------
P
K
L
F
K
D
M
F
D
Q
I
I
Q
F
T
D
M
V
I
K
N
K
D
L
E
P
P
A
R
T
T
A
L
E
L
L
T
V
F
S
E
N
A
------------
P
Q
M
C
K
S
N
Q
N
Y
G
Q
T
L
V
M
V
T
L
I
M
M
T
E
V
S
I
D
D
D
D
A
A
E
W
I
E
S
D
D
T
-------
D
D
E
E
E
V
T
Y
D
H
A
R
Q
A
L
D
R
V
A
L
K
L
G
G
--
E
Y
L
A
A
-
P
L
F
Q
Y
L
Q
Q
M
I
T
S
T
E
W
R
E
R
F
A
A
M
M
-
A
L
S
S
A
A
E
G
C
A
D
V
L
I
G
E
I
P
K
I
L
D
M
V
I
P
L
I
N
D
------
P
H
P
R
V
Q
Y
G
C
C
N
V
L
G
Q
I
S
T
D
F
S
P
F
I
Q
R
T
A
H
D
R
I
L
P
A
L
I
S
K
L
T
S
E
C
T
S
R
V
Q
T
H
A
A
A
A
L
V
N
F
S
E
F
A
S
K
D
I
L
E
P
Y
L
D
S
L
L
T
N
L
L
V
L
L
Q
S
N
K
L
Y
V
Q
E
Q
A
L
T
T
I
A
--
F
I
A
E
A
A
K
N
K
F
I
K
Y
Y
D
T
L
M
P
L
L
L
N
V
L
K
V
---
N
S
V
L
K
G
K
C
M
E
C
A
T
L
I
G
F
A
V
G
K
E
K
F
H
E
H
S
Q
E
L
I
S
I
L
V
A
L
Q
N
S
D
A
L
R
S
Y
L
E
Q
S
W
S
R
I
C
R
I
L
---------
G
D
D
F
V
P
L
L
P
I
V
I
P
P
L
L
I
T
A
K
A
T
Q
D
V
G
L
I
E
E
E
E
A
A
N
F
Q
Q
Y
P
D
W
D
V
V
Q
V
Q
G
K
H
I
A
I
H
T
S
V
L
D
D
K
V
S
A
M
E
L
L
Q
S
Y
A
T
L
L
R
G
QFAVY
V
K
E
V
M
E
EI
A
L
P
S
L
D
FYLH
D
G
V
R
A
A
G
A
T
L
I
P
I
L
L
S
C
L
L
A
AE
E
L
V
L
L
W
H
K
A
S
S
K
L
I
G
G
L
M
S
EPM
P
E
I
T
Q
V
Y
H
N
S
L
V
N
G
I
K
V
M
GDNCLS
E
D
Q
L
A
A
F
T
K
G
V
S
A
N
L
T
D
T
Y
E
R
M
Q
DRDEYNED
F
T
D
E
D
L
L
D
E
I
N
K
S
I
A
A
V
L
K
T
T
N
GHY
L
K
N
L
E
N
I
W
P
M
I
N
T
F
L
LE
P
I
L
V
I
F
A
L
V
V
I
G
D
L
I
Q
YEQTASMKNAF
I
P
K
V
T
E
C
L
ISPD
A
R
I
R
Q
A
A
S
Y
I
I
G
V
C
A
Q
YAPSTYADVCIPT
L
D
T
L
V
Q
I
V
DGSKLEEN
R
S
S
T
E
N
A
S
A
A
I
A
K
I
L
Y
A
Y
NSNIPD
T
Y
T
A
N
W
F
K
T
LPTITD
K
E
A
A
S
F
N
Y
Q
F
L
S
QVCAQSN
I
S
A
V
V
D
S
V
I
Q
A
L
N
E
RSLT
V
I
S
S
V
K
K
L
L
G
F
L
P
S
S
D
A
M
A
I
F
N
RYP
A
D
I
M
E
K
V
H
K
W
F
29
HHSearch
30.40
19%
-102
- C1 -
-
5MFI
-
?
B:
[4-34]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
L
P
Q
M
V
Q
Q
L
N
S
P
D
Q
Q
E
L
Q
S
A
L
R
K
L
S
Q
I
A
S
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
30.15
12%
-182
- C1 -
-
1EE4
-
IMA1_YEAST
B:
[82-158]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
V
D
A
D
A
V
P
L
F
I
Q
L
L
Y
T
G
S
V
E
V
K
E
Q
A
I
W
A
L
G
N
V
A
G
D
S
T
D
Y
R
D
Y
V
L
Q
C
N
A
M
E
P
I
L
G
L
F
N
S
-
N
K
P
S
L
I
R
T
A
T
W
T
L
S
N
L
C
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
29.96
9%
-193
- C1 -
-
4FDD
-
TNPO1_HUMAN
A:
[649-746]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
F
A
L
L
G
D
L
T
K
A
C
F
-
Q
H
V
K
P
C
I
A
D
F
M
P
I
L
G
T
N
L
N
P
E
F
I
S
V
C
N
N
A
T
W
A
I
G
E
--
I
S
I
Q
M
G
I
E
M
Q
P
Y
I
P
M
V
L
H
Q
L
V
E
I
I
N
R
P
N
T
P
K
T
L
L
E
N
T
A
I
T
I
G
R
L
G
Y
V
-
C
P
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------