@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : AAKG1_HUMAN: (2018-07-12 )
METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP
Atome Classification :
(25 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
METVISSDSSPAVENEHPQETPESN
N
S
V
Y
T
S
F
M
K
SHR
C
Y
D
LIPTS
S
K
L
V
V
F
DTS
L
Q
V
K
K
A
F
F
A
L
V
TNGVRAAPLWDSKKQ
S
F
V
G
M
L
T
I
T
D
F
I
N
I
L
H
R
Y
Y
K
S
A
L
V
Q
I
Y
E
L
E
E
H
K
I
E
T
W
R
E
V
Y
L
QDSFK
P
L
V
C
ISPN
A
S
L
F
D
A
V
S
S
L
I
R
N
K
I
HRLPVIDPESG
N
T
L
Y
I
L
T
H
K
R
I
L
K
F
L
K
L
F
I
T
EFP
K
P
E
F
M
S
K
S
L
E
E
LQIG
T
Y
A
N
I
A
M
V
RTTT
P
V
Y
V
A
L
G
I
F
V
Q
H
R
VSALPVVDEKG
R
V
V
D
I
YSKF
D
V
I
N
L
A
A
E
KTYNNL
D
V
S
V
T
K
A
L
Q
H
R
S
H
Y
F
E
G
V
L
K
C
Y
L
H
E
T
L
E
T
I
I
N
R
L
V
E
A
E
V
H
R
L
V
V
VDE
N
D
V
V
K
G
I
V
S
L
S
D
I
L
Q
A
L
V
LTGGEKKP
3
PsiBlast_PDB
97.62
100%
-201
- C1 -
-
5ISO
3
AAKG1_HUMAN
E:
[27-324]
--------------------------
S
V
Y
T
S
F
M
K
S
H
R
C
Y
D
L
I
P
T
S
S
K
L
V
V
F
D
T
S
L
Q
V
K
K
A
F
F
A
L
V
T
N
G
V
R
A
A
P
L
W
D
S
K
K
Q
S
F
V
G
M
L
T
I
T
D
F
I
N
I
L
H
R
Y
Y
K
S
A
L
V
Q
I
Y
E
L
E
E
H
K
I
E
T
W
R
E
V
Y
L
Q
D
S
F
K
P
L
V
C
I
S
P
N
A
S
L
F
D
A
V
S
S
L
I
R
N
K
I
H
R
L
P
V
I
D
P
E
S
G
N
T
L
Y
I
L
T
H
K
R
I
L
K
F
L
K
L
F
I
T
E
F
P
K
P
E
F
M
S
K
S
L
E
E
L
Q
I
G
T
Y
A
N
I
A
M
V
R
T
T
T
P
V
Y
V
A
L
G
I
F
V
Q
H
R
V
S
A
L
P
V
V
D
E
K
G
R
V
V
D
I
Y
S
K
F
D
V
I
N
L
A
A
E
K
T
Y
N
N
L
D
V
S
V
T
K
A
L
Q
H
R
S
H
Y
F
E
G
V
L
K
C
Y
L
H
E
T
L
E
T
I
I
N
R
L
V
E
A
E
V
H
R
L
V
V
V
D
E
N
D
V
V
K
G
I
V
S
L
S
D
I
L
Q
A
L
V
L
-------
32
HHSearch
95.81
100%
-197
- C1 -
-
4REW
3
AAKG1_HUMAN
G:
[4-302]
--------------------------
S
V
Y
T
S
F
M
K
S
H
R
C
Y
D
L
I
P
T
S
S
K
L
V
V
F
D
T
S
L
Q
V
K
K
A
F
F
A
L
V
T
N
G
V
R
A
A
P
L
W
D
S
K
K
Q
S
F
V
G
M
L
T
I
T
D
F
I
N
I
L
H
R
Y
Y
K
S
A
L
V
Q
I
Y
E
L
E
E
H
K
I
E
T
W
R
E
V
Y
L
Q
D
S
F
K
P
L
V
C
I
S
P
N
A
S
L
F
D
A
V
S
S
L
I
R
N
K
I
H
R
L
P
V
I
D
P
E
S
G
N
T
L
Y
I
L
T
H
K
R
I
L
K
F
L
K
L
F
I
T
E
F
P
K
P
E
F
M
S
K
S
L
E
E
L
Q
I
G
T
Y
A
N
I
A
M
V
R
T
T
T
P
V
Y
V
A
L
G
I
F
V
Q
H
R
V
S
A
L
P
V
V
D
E
K
G
R
V
V
D
I
Y
S
K
F
D
V
I
N
L
A
A
E
K
T
Y
N
N
L
D
V
S
V
T
K
A
L
Q
H
R
S
H
Y
F
E
G
V
L
K
C
Y
L
H
E
T
L
E
T
I
I
N
R
L
V
E
A
E
V
H
R
L
V
V
V
D
E
N
D
V
V
K
G
I
V
S
L
S
D
I
L
Q
A
L
V
L
T
------
5
PsiBlast_PDB
95.73
100%
-194
- C1 -
-
5EZV
2
AAKG1_HUMAN
E:
[29-331]
-----------------------
S
N
N
S
V
Y
T
S
F
M
K
S
H
R
C
Y
D
L
I
P
T
S
S
K
L
V
V
F
D
T
S
L
Q
V
K
K
A
F
F
A
L
V
T
N
G
V
R
A
A
P
L
W
D
S
K
K
Q
S
F
V
G
M
L
T
I
T
D
F
I
N
I
L
H
R
Y
Y
K
S
A
L
V
Q
I
Y
E
L
E
E
H
K
I
E
T
W
R
E
V
Y
L
Q
-
S
F
K
P
L
V
C
I
S
P
N
A
S
L
F
D
A
V
S
S
L
I
R
N
K
I
H
R
L
P
V
I
D
P
E
S
G
N
T
L
Y
I
L
T
H
K
R
I
L
K
F
L
K
L
F
I
T
E
F
P
K
P
E
F
M
S
K
S
L
E
E
L
Q
I
G
T
Y
A
N
I
A
M
V
R
T
T
T
P
V
Y
V
A
L
G
I
F
V
Q
H
R
V
S
A
L
P
V
V
D
E
K
G
R
V
V
D
I
Y
S
K
F
D
V
I
N
L
A
A
E
K
T
Y
N
N
L
D
V
S
V
T
K
A
L
Q
H
R
S
H
Y
F
E
G
V
L
K
C
Y
L
H
E
T
L
E
T
I
I
N
R
L
V
E
A
E
V
H
R
L
V
V
V
D
E
N
D
V
V
K
G
I
V
S
L
S
D
I
L
Q
A
L
V
L
T
G
-----
4
PsiBlast_PDB
95.73
100%
-204
- C1 -
-
4ZHX
2
AAKG1_HUMAN
E:
[32-329]
--------------------------
S
V
Y
T
S
F
M
K
S
H
R
C
Y
D
L
I
P
T
S
S
K
L
V
V
F
D
T
S
L
Q
V
K
K
A
F
F
A
L
V
T
N
G
V
R
A
A
P
L
W
D
S
K
K
Q
S
F
V
G
M
L
T
I
T
D
F
I
N
I
L
H
R
Y
Y
K
S
A
L
V
Q
I
Y
E
L
E
E
H
K
I
E
T
W
R
E
V
Y
L
Q
D
S
F
K
P
L
V
C
I
S
P
N
A
S
L
F
D
A
V
S
S
L
I
R
N
K
I
H
R
L
P
V
I
D
P
E
S
G
N
T
L
Y
I
L
T
H
K
R
I
L
K
F
L
K
L
F
I
T
E
F
P
K
P
E
F
M
S
K
S
L
E
E
L
Q
I
G
T
Y
A
N
I
A
M
V
R
T
T
T
P
V
Y
V
A
L
G
I
F
V
Q
H
R
V
S
A
L
P
V
V
D
E
K
G
R
V
V
D
I
Y
S
K
F
D
V
I
N
L
A
A
E
K
T
Y
N
N
L
D
V
S
V
T
K
A
L
Q
H
R
S
H
Y
F
E
G
V
L
K
C
Y
L
H
E
T
L
E
T
I
I
N
R
L
V
E
A
E
V
H
R
L
V
V
V
D
E
N
D
V
V
K
G
I
V
S
L
S
D
I
L
Q
A
L
V
L
-------
9
PsiBlast_PDB
95.52
96%
-196
- C1 -
-
2Y8L
3
AAKG1_RAT
E:
[23-326]
-----------------------
S
N
S
S
V
Y
T
T
F
M
K
S
H
R
C
Y
D
L
I
P
T
S
S
K
L
V
V
F
D
T
S
L
Q
V
K
K
A
F
F
A
L
V
T
N
G
V
R
A
A
P
L
W
D
S
K
K
Q
S
F
V
G
M
L
T
I
T
D
F
I
N
I
L
H
R
Y
Y
K
S
A
L
V
Q
I
Y
E
L
E
E
H
K
I
E
T
W
R
E
V
Y
L
Q
D
S
F
K
P
L
V
C
I
S
P
N
A
S
L
F
D
A
V
S
S
L
I
R
N
K
I
H
R
L
P
V
I
D
P
E
S
G
N
T
L
Y
I
L
T
H
K
R
I
L
K
F
L
K
L
F
I
T
E
F
P
K
P
E
F
M
S
K
S
L
E
E
L
Q
I
G
T
Y
A
N
I
A
M
V
R
T
T
T
P
V
Y
V
A
L
G
I
F
V
Q
H
R
V
S
A
L
P
V
V
D
E
K
G
R
V
V
D
I
Y
S
K
F
D
V
I
N
L
A
A
E
K
T
Y
N
N
L
D
V
S
V
T
K
A
L
Q
H
R
S
H
Y
F
E
G
V
L
K
C
Y
L
H
E
T
L
E
A
I
I
N
R
L
V
E
A
E
V
H
R
L
V
V
V
D
E
H
D
V
V
K
G
I
V
S
L
S
D
I
L
Q
A
L
V
L
T
G
G
----
11
PsiBlast_PDB
95.13
96%
-200
- C1 -
-
2YA3
3
AAKG1_RAT
E:
[25-324]
-------------------------
S
S
V
Y
T
T
F
M
K
S
H
R
C
Y
D
L
I
P
T
S
S
K
L
V
V
F
D
T
S
L
Q
V
K
K
A
F
F
A
L
V
T
N
G
V
R
A
A
P
L
W
D
S
K
K
Q
S
F
V
G
M
L
T
I
T
D
F
I
N
I
L
H
R
Y
Y
K
S
A
L
V
Q
I
Y
E
L
E
E
H
K
I
E
T
W
R
E
V
Y
L
Q
D
S
F
K
P
L
V
C
I
S
P
N
A
S
L
F
D
A
V
S
S
L
I
R
N
K
I
H
R
L
P
V
I
D
P
E
S
G
N
T
L
Y
I
L
T
H
K
R
I
L
K
F
L
K
L
F
I
T
E
F
P
K
P
E
F
M
S
K
S
L
E
E
L
Q
I
G
T
Y
A
N
I
A
M
V
R
T
T
T
P
V
Y
V
A
L
G
I
F
V
Q
H
R
V
S
A
L
P
V
V
D
E
K
G
R
V
V
D
I
Y
S
K
F
D
V
I
N
L
A
A
E
K
T
Y
N
N
L
D
V
S
V
T
K
A
L
Q
H
R
S
H
Y
F
E
G
V
L
K
C
Y
L
H
E
T
L
E
A
I
I
N
R
L
V
E
A
E
V
H
R
L
V
V
V
D
E
H
D
V
V
K
G
I
V
S
L
S
D
I
L
Q
A
L
V
L
T
------
8
PsiBlast_PDB
94.42
96%
-190
- C1 -
-
2V9J
3
AAKG1_RAT
E:
[23-326]
-----------------------
S
N
S
S
V
Y
T
T
F
M
K
S
H
R
C
Y
D
L
I
P
T
S
S
K
L
V
V
F
D
T
S
L
Q
V
K
K
A
F
F
A
L
V
T
N
G
V
R
A
A
P
L
W
D
S
K
K
Q
S
F
V
G
M
L
T
I
T
D
F
I
N
I
L
H
R
Y
Y
K
S
A
L
V
Q
I
Y
E
L
E
E
H
K
I
E
T
W
R
E
V
Y
L
Q
D
S
F
K
P
L
V
C
I
S
P
N
A
S
L
F
D
A
V
S
S
L
I
R
N
K
I
H
R
L
P
V
I
D
P
E
S
G
N
T
L
Y
I
L
T
H
K
R
I
L
K
F
L
K
L
F
I
T
E
F
P
K
P
E
F
M
S
K
S
L
E
E
L
Q
I
G
T
Y
A
N
I
A
M
V
R
T
T
T
P
V
Y
V
A
L
G
I
F
V
Q
H
R
V
S
A
L
P
V
V
D
E
K
G
R
V
V
D
I
Y
S
K
F
D
V
I
N
L
A
A
E
K
T
Y
N
N
L
D
V
S
V
T
K
A
L
Q
H
R
S
H
Y
F
E
G
V
L
K
C
Y
L
H
E
T
L
E
A
I
I
N
R
L
V
E
A
E
V
H
R
L
V
V
V
D
E
H
D
V
V
K
G
I
V
S
L
S
D
I
L
Q
A
L
V
L
T
G
G
----
2
PsiBlast_PDB
93.72
100%
-190
- C1 -
-
4CFF
2
AAKG1_HUMAN
E:
[27-325]
--------------------------
S
V
Y
T
S
F
M
K
S
H
R
C
Y
D
L
I
P
T
S
S
K
L
V
V
F
D
T
S
L
Q
V
K
K
A
F
F
A
L
V
T
N
G
V
R
A
A
P
L
W
D
S
K
K
Q
S
F
V
G
M
L
T
I
T
D
F
I
N
I
L
H
R
Y
Y
K
S
A
L
V
Q
I
Y
E
L
E
E
H
K
I
E
T
W
R
E
V
Y
L
Q
D
S
F
K
P
L
V
C
I
S
P
N
A
S
L
F
D
A
V
S
S
L
I
R
N
K
I
H
R
L
P
V
I
D
P
E
S
G
N
T
L
Y
I
L
T
H
K
R
I
L
K
F
L
K
L
F
I
T
E
F
P
K
P
E
F
M
S
K
S
L
E
E
L
Q
I
G
T
Y
A
N
I
A
M
V
R
T
T
T
P
V
Y
V
A
L
G
I
F
V
Q
H
R
V
S
A
L
P
V
V
D
E
K
G
R
V
V
D
I
Y
S
K
F
D
V
I
N
L
A
A
E
K
T
Y
N
N
L
D
V
S
V
T
K
A
L
Q
H
R
S
H
Y
F
E
G
V
L
K
C
Y
L
H
E
T
L
E
T
I
I
N
R
L
V
E
A
E
V
H
R
L
V
V
V
D
E
N
D
V
V
K
G
I
V
S
L
S
D
I
L
Q
A
L
V
L
T
------
19
PsiBlast_PDB
93.66
96%
-199
- C1 -
-
5T5T
3
AAKG1_RAT
C:
[26-322]
--------------------------
S
V
Y
T
T
F
M
K
S
H
R
C
Y
D
L
I
P
T
S
S
K
L
V
V
F
D
T
S
L
Q
V
K
K
A
F
F
A
L
V
T
N
G
V
R
A
A
P
L
W
D
S
K
K
Q
S
F
V
G
M
L
T
I
T
D
F
I
N
I
L
H
R
Y
Y
K
S
A
L
V
Q
I
Y
E
L
E
E
H
K
I
E
T
W
R
E
V
Y
L
Q
D
S
F
K
P
L
V
C
I
S
P
N
A
S
L
F
D
A
V
S
S
L
I
R
N
K
I
H
R
L
P
V
I
D
P
E
S
G
N
T
L
Y
I
L
T
H
K
R
I
L
K
F
L
K
L
F
I
T
E
F
P
K
P
E
F
M
S
K
S
L
E
E
L
Q
I
G
T
Y
A
N
I
A
M
V
R
T
T
T
P
V
Y
V
A
L
G
I
F
V
Q
H
R
V
S
A
L
P
V
V
D
E
K
G
R
V
V
D
I
Y
S
K
F
D
V
I
N
L
A
A
E
K
T
Y
N
N
L
D
V
S
V
T
K
A
L
Q
H
R
----
E
G
V
L
K
C
Y
L
H
E
T
L
E
A
I
I
N
R
L
V
E
A
E
V
H
R
L
V
V
V
D
E
H
D
V
V
K
G
I
V
S
L
S
D
I
L
Q
A
L
V
--------
7
PsiBlast_PDB
93.39
96%
-189
- C1 -
-
2V92
3
AAKG1_RAT
E:
[23-326]
-----------------------
S
N
S
S
V
Y
T
T
F
M
K
S
H
R
C
Y
D
L
I
P
T
S
S
K
L
V
V
F
D
T
S
L
Q
V
K
K
A
F
F
A
L
V
T
N
G
V
R
A
A
P
L
W
D
S
K
K
Q
S
F
V
G
M
L
T
I
T
D
F
I
N
I
L
H
R
Y
Y
K
S
A
L
V
Q
I
Y
E
L
E
E
H
K
I
E
T
W
R
E
V
Y
L
Q
D
S
F
K
P
L
V
C
I
S
P
N
A
S
L
F
D
A
V
S
S
L
I
R
N
K
I
H
R
L
P
V
I
D
P
E
S
G
N
T
L
Y
I
L
T
H
K
R
I
L
K
F
L
K
L
F
I
T
E
F
P
K
P
E
F
M
S
K
S
L
E
E
L
Q
I
G
T
Y
A
N
I
A
M
V
R
T
T
T
P
V
Y
V
A
L
G
I
F
V
Q
H
R
V
S
A
L
P
V
V
D
E
K
G
R
V
V
D
I
Y
S
K
F
D
V
I
N
L
A
A
E
K
T
Y
N
N
L
D
V
S
V
T
K
A
L
Q
H
R
S
H
Y
F
E
G
V
L
K
C
Y
L
H
E
T
L
E
A
I
I
N
R
L
V
E
A
E
V
H
R
L
V
V
V
D
E
H
D
V
V
K
G
I
V
S
L
S
D
I
L
Q
A
L
V
L
T
G
G
----
10
PsiBlast_PDB
93.27
96%
-184
- C1 -
-
2Y8Q
2
AAKG1_RAT
E:
[23-326]
-----------------------
S
N
S
S
V
Y
T
T
F
M
K
S
H
R
C
Y
D
L
I
P
T
S
S
K
L
V
V
F
D
T
S
L
Q
V
K
K
A
F
F
A
L
V
T
N
G
V
R
A
A
P
L
W
D
S
K
K
Q
S
F
V
G
M
L
T
I
T
D
F
I
N
I
L
H
R
Y
Y
K
S
A
L
V
Q
I
Y
E
L
E
E
H
K
I
E
T
W
R
E
V
Y
L
Q
D
S
F
K
P
L
V
C
I
S
P
N
A
S
L
F
D
A
V
S
S
L
I
R
N
K
I
H
R
L
P
V
I
D
P
E
S
G
N
T
L
Y
I
L
T
H
K
R
I
L
K
F
L
K
L
F
I
T
E
F
P
K
P
E
F
M
S
K
S
L
E
E
L
Q
I
G
T
Y
A
N
I
A
M
V
R
T
T
T
P
V
Y
V
A
L
G
I
F
V
Q
H
R
V
S
A
L
P
V
V
D
E
K
G
R
V
V
D
I
Y
S
K
F
D
V
I
N
L
A
A
E
K
T
Y
N
N
L
D
V
S
V
T
K
A
L
Q
H
R
S
H
Y
F
E
G
V
L
K
C
Y
L
H
E
T
L
E
A
I
I
N
R
L
V
E
A
E
V
H
R
L
V
V
V
D
E
H
D
V
V
K
G
I
V
S
L
S
D
I
L
Q
A
L
V
L
T
G
G
----
14
PsiBlast_PDB
93.11
96%
-198
- C1 -
-
4CFH
2
AAKG1_RAT
E:
[24-324]
------------------------
N
S
S
V
Y
T
T
F
M
K
S
H
R
C
Y
D
L
I
P
T
S
S
K
L
V
V
F
D
T
S
L
Q
V
K
K
A
F
F
A
L
V
T
N
G
V
R
A
A
P
L
W
D
S
K
K
Q
S
F
V
G
M
L
T
I
T
D
F
I
N
I
L
H
R
Y
Y
K
S
A
L
V
Q
I
Y
E
L
E
E
H
K
I
E
T
W
R
E
V
Y
L
Q
D
S
F
K
P
L
V
C
I
S
P
N
A
S
L
F
D
A
V
S
S
L
I
R
N
K
I
H
R
L
P
V
I
D
P
E
S
G
N
T
L
Y
I
L
T
H
K
R
I
L
K
F
L
K
L
F
I
T
E
F
P
K
P
E
F
M
S
K
S
L
E
E
L
Q
I
G
T
Y
A
N
I
A
M
V
R
T
T
T
P
V
Y
V
A
L
G
I
F
V
Q
H
R
V
S
A
L
P
V
V
D
E
K
G
R
V
V
D
I
Y
S
K
F
D
V
I
N
L
A
A
E
K
T
Y
N
N
L
D
V
S
V
T
K
A
L
Q
H
R
S
H
Y
F
E
G
V
L
K
C
Y
L
H
E
T
L
E
A
I
I
N
R
L
V
E
A
E
V
H
R
L
V
V
V
D
E
H
D
V
V
K
G
I
V
S
L
S
D
I
L
Q
A
L
V
L
T
------
31
HHSearch
92.92
99%
-187
- C1 -
-
2V8Q
3
AAKG1_RAT
E:
[23-326]
-----------------------
S
N
S
S
V
Y
T
T
F
M
K
S
H
R
C
Y
D
L
I
P
T
S
S
K
L
V
V
F
D
T
S
L
Q
V
K
K
A
F
F
A
L
V
T
N
G
V
R
A
A
P
L
W
D
S
K
K
Q
S
F
V
G
M
L
T
I
T
D
F
I
N
I
L
H
R
Y
Y
K
S
A
L
V
Q
I
Y
E
L
E
E
H
K
I
E
T
W
R
E
V
Y
L
Q
D
S
F
K
P
L
V
C
I
S
P
N
A
S
L
F
D
A
V
S
S
L
I
R
N
K
I
H
R
L
P
V
I
D
P
E
S
G
N
T
L
Y
I
L
T
H
K
R
I
L
K
F
L
K
L
F
I
T
E
F
P
K
P
E
F
M
S
K
S
L
E
E
L
Q
I
G
T
Y
A
N
I
A
M
V
R
T
T
T
P
V
Y
V
A
L
G
I
F
V
Q
H
R
V
S
A
L
P
V
V
D
E
K
G
R
V
V
D
I
Y
S
K
F
D
V
I
N
L
A
A
E
K
T
Y
N
N
L
D
V
S
V
T
K
A
L
Q
H
R
S
H
Y
F
E
G
V
L
K
C
Y
L
H
E
T
L
E
A
I
I
N
R
L
V
E
A
E
V
H
R
L
V
V
V
D
E
H
D
V
V
K
G
I
V
S
L
S
D
I
L
Q
A
L
V
L
T
G
G
----
20
PsiBlast_PDB
92.91
96%
-203
- C1 -
-
5UFU
3
AAKG1_RAT
C:
[26-322]
--------------------------
S
V
Y
T
T
F
M
K
S
H
R
C
Y
D
L
I
P
T
S
S
K
L
V
V
F
D
T
S
L
Q
V
K
K
A
F
F
A
L
V
T
N
G
V
R
A
A
P
L
W
D
S
K
K
Q
S
F
V
G
M
L
T
I
T
D
F
I
N
I
L
H
R
Y
Y
K
S
A
L
V
Q
I
Y
E
L
E
E
H
K
I
E
T
W
R
E
V
Y
L
Q
D
---
P
L
V
C
I
S
P
N
A
S
L
F
D
A
V
S
S
L
I
R
N
K
I
H
R
L
P
V
I
D
P
E
S
G
N
T
L
Y
I
L
T
H
K
R
I
L
K
F
L
K
L
F
I
T
E
F
P
K
P
E
F
M
S
K
S
L
E
E
L
Q
I
G
T
Y
A
N
I
A
M
V
R
T
T
T
P
V
Y
V
A
L
G
I
F
V
Q
H
R
V
S
A
L
P
V
V
D
E
K
G
R
V
V
D
I
Y
S
K
F
D
V
I
N
L
A
A
E
K
T
Y
N
N
L
D
V
S
V
T
K
A
L
Q
H
R
-----
G
V
L
K
C
Y
L
H
E
T
L
E
A
I
I
N
R
L
V
E
A
E
V
H
R
L
V
V
V
D
E
H
D
V
V
K
G
I
V
S
L
S
D
I
L
Q
A
L
V
--------
15
PsiBlast_PDB
92.88
96%
-204
- C1 -
-
4QFG
1
AAKG1_RAT
C:
[25-322]
-------------------------
S
S
V
Y
T
T
F
M
K
S
H
R
C
Y
D
L
I
P
T
S
S
K
L
V
V
F
D
T
S
L
Q
V
K
K
A
F
F
A
L
V
T
N
G
V
R
A
A
P
L
W
D
S
K
K
Q
S
F
V
G
M
L
T
I
T
D
F
I
N
I
L
H
R
Y
Y
K
S
A
L
V
Q
I
Y
E
L
E
E
H
K
I
E
T
W
R
E
V
Y
L
Q
----
P
L
V
C
I
S
P
N
A
S
L
F
D
A
V
S
S
L
I
R
N
K
I
H
R
L
P
V
I
D
P
E
S
G
N
T
L
Y
I
L
T
H
K
R
I
L
K
F
L
K
L
F
I
T
E
F
P
K
P
E
F
M
S
K
S
L
E
E
L
Q
I
G
T
Y
A
N
I
A
M
V
R
T
T
T
P
V
Y
V
A
L
G
I
F
V
Q
H
R
V
S
A
L
P
V
V
D
E
K
G
R
V
V
D
I
Y
S
K
F
D
V
I
N
L
A
A
E
K
T
Y
N
N
L
D
V
S
V
T
K
A
L
Q
H
R
-------
L
K
C
Y
L
H
E
T
L
E
A
I
I
N
R
L
V
E
A
E
V
H
R
L
V
V
V
D
E
H
D
V
V
K
G
I
V
S
L
S
D
I
L
Q
A
L
V
--------
1
PsiBlast_PDB
92.76
100%
-197
- C1 -
-
4CFE
3
AAKG1_HUMAN
E:
[27-325]
--------------------------
S
V
Y
T
S
F
M
K
S
H
R
C
Y
D
L
I
P
T
S
S
K
L
V
V
F
D
T
S
L
Q
V
K
K
A
F
F
A
L
V
T
N
G
V
R
A
A
P
L
W
D
S
K
K
Q
S
F
V
G
M
L
T
I
T
D
F
I
N
I
L
H
R
Y
Y
K
S
A
L
V
Q
I
Y
E
L
E
E
H
K
I
E
T
W
R
E
V
Y
L
-----
P
L
V
C
I
S
P
N
A
S
L
F
D
A
V
S
S
L
I
R
N
K
I
H
R
L
P
V
I
D
P
E
S
G
N
T
L
Y
I
L
T
H
K
R
I
L
K
F
L
K
L
F
I
T
E
F
P
K
P
E
F
M
S
K
S
L
E
E
L
Q
I
G
T
Y
A
N
I
A
M
V
R
T
T
T
P
V
Y
V
A
L
G
I
F
V
Q
H
R
V
S
A
L
P
V
V
D
E
K
G
R
V
V
D
I
Y
S
K
F
D
V
I
N
L
A
A
E
K
T
Y
N
N
L
D
V
S
V
T
K
A
L
Q
H
R
S
H
Y
F
E
G
V
L
K
C
Y
L
H
E
T
L
E
T
I
I
N
R
L
V
E
A
E
V
H
R
L
V
V
V
D
E
N
D
V
V
K
G
I
V
S
L
S
D
I
L
Q
A
L
V
L
T
------
23
Fugue
92.71
98%
-187
- C1 -
-
2V8Q
3
AAKG1_RAT
E:
[23-326]
-----------------------
S
N
S
S
V
Y
T
T
F
M
K
S
H
R
C
Y
D
L
I
P
T
S
S
K
L
V
V
F
D
T
S
L
Q
V
K
K
A
F
F
A
L
V
T
N
G
V
R
A
A
P
L
W
D
S
K
K
Q
S
F
V
G
M
L
T
I
T
D
F
I
N
I
L
H
R
Y
Y
K
S
A
L
V
Q
I
Y
E
L
E
E
H
K
I
E
T
W
R
E
V
Y
L
Q
D
S
F
K
P
L
V
C
I
S
P
N
A
S
L
F
D
A
V
S
S
L
I
R
N
K
I
H
R
L
P
V
I
D
P
E
S
G
N
T
L
Y
I
L
T
H
K
R
I
L
K
F
L
K
L
F
I
T
E
F
P
K
P
E
F
M
S
K
S
L
E
E
L
Q
I
G
T
Y
A
N
I
A
M
V
R
T
T
T
P
V
Y
V
A
L
G
I
F
V
Q
H
R
V
S
A
L
P
V
V
D
E
K
G
R
V
V
D
I
Y
S
K
F
D
V
I
N
L
A
A
E
K
T
Y
N
N
L
D
V
S
V
T
K
A
L
Q
H
R
S
H
Y
F
E
G
V
L
K
C
Y
L
H
E
T
L
E
A
I
I
N
R
L
V
E
A
E
V
H
R
L
V
V
V
D
E
H
D
V
V
K
G
I
V
S
L
S
D
I
L
Q
A
L
V
L
T
G
G
----
6
PsiBlast_PDB
92.28
96%
-187
- C1 -
-
2V8Q
3
AAKG1_RAT
E:
[23-326]
-----------------------
S
N
S
S
V
Y
T
T
F
M
K
S
H
R
C
Y
D
L
I
P
T
S
S
K
L
V
V
F
D
T
S
L
Q
V
K
K
A
F
F
A
L
V
T
N
G
V
R
A
A
P
L
W
D
S
K
K
Q
S
F
V
G
M
L
T
I
T
D
F
I
N
I
L
H
R
Y
Y
K
S
A
L
V
Q
I
Y
E
L
E
E
H
K
I
E
T
W
R
E
V
Y
L
Q
D
S
F
K
P
L
V
C
I
S
P
N
A
S
L
F
D
A
V
S
S
L
I
R
N
K
I
H
R
L
P
V
I
D
P
E
S
G
N
T
L
Y
I
L
T
H
K
R
I
L
K
F
L
K
L
F
I
T
E
F
P
K
P
E
F
M
S
K
S
L
E
E
L
Q
I
G
T
Y
A
N
I
A
M
V
R
T
T
T
P
V
Y
V
A
L
G
I
F
V
Q
H
R
V
S
A
L
P
V
V
D
E
K
G
R
V
V
D
I
Y
S
K
F
D
V
I
N
L
A
A
E
K
T
Y
N
N
L
D
V
S
V
T
K
A
L
Q
H
R
S
H
Y
F
E
G
V
L
K
C
Y
L
H
E
T
L
E
A
I
I
N
R
L
V
E
A
E
V
H
R
L
V
V
V
D
E
H
D
V
V
K
G
I
V
S
L
S
D
I
L
Q
A
L
V
L
T
G
G
----
21
Fugue
92.22
98%
-205
- C1 -
-
4QFR
3
AAKG1_RAT
C:
[28-322]
----------------------------
Y
T
T
F
M
K
S
H
R
C
Y
D
L
I
P
T
S
S
K
L
V
V
F
D
T
S
L
Q
V
K
K
A
F
F
A
L
V
T
N
G
V
R
A
A
P
L
W
D
S
K
K
Q
S
F
V
G
M
L
T
I
T
D
F
I
N
I
L
H
R
Y
Y
K
S
A
L
V
Q
I
Y
E
L
E
E
H
K
I
E
T
W
R
E
V
Y
L
Q
D
S
F
K
P
L
V
C
I
S
P
N
A
S
L
F
D
A
V
S
S
L
I
R
N
K
I
H
R
L
P
V
I
D
P
E
S
G
N
T
L
Y
I
L
T
H
K
R
I
L
K
F
L
K
L
F
I
T
----------
S
L
E
E
L
Q
I
G
T
Y
A
N
I
A
M
V
R
T
T
T
P
V
Y
V
A
L
G
I
F
V
Q
H
R
V
S
A
L
P
V
V
D
E
K
G
R
V
V
D
I
Y
S
K
F
D
V
I
N
L
A
A
E
K
T
Y
N
N
L
D
V
S
V
T
K
A
L
Q
H
R
------
V
L
K
C
Y
L
H
E
T
L
E
A
I
I
N
R
L
V
E
A
E
V
H
R
L
V
V
V
D
E
H
D
V
V
K
G
I
V
S
L
S
D
I
L
Q
A
L
V
--------
13
PsiBlast_PDB
91.97
96%
-194
- C1 -
-
4EAL
2
AAKG1_RAT
C:
[23-324]
-----------------------
S
N
S
S
V
Y
T
T
F
M
K
S
H
R
C
Y
D
L
I
P
T
S
S
K
L
V
V
F
D
T
S
L
Q
V
K
K
A
F
F
A
L
V
T
N
G
V
R
A
A
P
L
W
D
S
K
K
Q
S
F
V
G
M
L
T
I
T
D
F
I
N
I
L
H
R
----------
E
L
E
E
H
K
I
E
T
W
R
E
V
Y
L
Q
D
S
F
K
P
L
V
C
I
S
P
N
A
S
L
F
D
A
V
S
S
L
I
R
N
K
I
H
R
L
P
V
I
D
P
E
S
G
N
T
L
Y
I
L
T
H
K
R
I
L
K
F
L
K
L
F
I
T
E
F
P
K
P
E
F
M
S
K
S
L
E
E
L
Q
I
G
T
Y
A
N
I
A
M
V
R
T
T
T
P
V
Y
V
A
L
G
I
F
V
Q
H
R
V
S
A
L
P
V
V
D
E
K
G
R
V
V
D
I
Y
S
K
F
D
V
I
N
L
A
A
E
K
T
--
N
L
D
V
S
V
T
K
A
L
Q
H
R
S
-----
V
L
K
C
Y
L
H
E
T
L
E
A
I
I
N
R
L
V
E
A
E
V
H
R
L
V
V
V
D
E
H
D
V
V
K
G
I
V
S
L
S
D
I
L
Q
A
L
V
L
T
------
16
PsiBlast_PDB
91.84
96%
-205
- C1 -
-
4QFR
3
AAKG1_RAT
C:
[28-322]
----------------------------
Y
T
T
F
M
K
S
H
R
C
Y
D
L
I
P
T
S
S
K
L
V
V
F
D
T
S
L
Q
V
K
K
A
F
F
A
L
V
T
N
G
V
R
A
A
P
L
W
D
S
K
K
Q
S
F
V
G
M
L
T
I
T
D
F
I
N
I
L
H
R
Y
Y
K
S
A
L
V
Q
I
Y
E
L
E
E
H
K
I
E
T
W
R
E
V
Y
L
Q
D
S
F
K
P
L
V
C
I
S
P
N
A
S
L
F
D
A
V
S
S
L
I
R
N
K
I
H
R
L
P
V
I
D
P
E
S
G
N
T
L
Y
I
L
T
H
K
R
I
L
K
F
L
K
L
F
I
T
----------
S
L
E
E
L
Q
I
G
T
Y
A
N
I
A
M
V
R
T
T
T
P
V
Y
V
A
L
G
I
F
V
Q
H
R
V
S
A
L
P
V
V
D
E
K
G
R
V
V
D
I
Y
S
K
F
D
V
I
N
L
A
A
E
K
T
Y
N
N
L
D
V
S
V
T
K
A
L
Q
H
R
------
V
L
K
C
Y
L
H
E
T
L
E
A
I
I
N
R
L
V
E
A
E
V
H
R
L
V
V
V
D
E
H
D
V
V
K
G
I
V
S
L
S
D
I
L
Q
A
L
V
--------
12
PsiBlast_PDB
91.63
96%
-188
- C1 -
-
4EAK
3
AAKG1_RAT
C:
[23-324]
-----------------------
S
N
S
S
V
Y
T
T
F
M
K
S
H
R
C
Y
D
L
I
P
T
S
S
K
L
V
V
F
D
T
S
L
Q
V
K
K
A
F
F
A
L
V
T
N
G
V
R
A
A
P
L
W
D
S
K
K
Q
S
F
V
G
M
L
T
I
T
D
F
I
N
I
L
H
R
----------
E
L
E
E
H
K
I
E
T
W
R
E
V
Y
L
Q
D
S
F
K
P
L
V
C
I
S
P
N
A
S
L
F
D
A
V
S
S
L
I
R
N
K
I
H
R
L
P
V
I
D
P
E
S
G
N
T
L
Y
I
L
T
H
K
R
I
L
K
F
L
K
L
F
I
T
E
F
P
K
P
E
F
M
S
K
S
L
E
E
L
Q
I
G
T
Y
A
N
I
A
M
V
R
T
T
T
P
V
Y
V
A
L
G
I
F
V
Q
H
R
V
S
A
L
P
V
V
D
E
K
G
R
V
V
D
I
Y
S
K
F
D
V
I
N
L
A
A
E
K
T
--
N
L
D
V
S
V
T
K
A
L
Q
H
R
S
-----
V
L
K
C
Y
L
H
E
T
L
E
A
I
I
N
R
L
V
E
A
E
V
H
R
L
V
V
V
D
E
H
D
V
V
K
G
I
V
S
L
S
D
I
L
Q
A
L
V
L
T
------
18
PsiBlast_PDB
91.19
96%
-205
- C1 -
-
5KQ5
3
AAKG1_RAT
C:
[28-322]
----------------------------
Y
T
T
F
M
K
S
H
R
C
Y
D
L
I
P
T
S
S
K
L
V
V
F
D
T
S
L
Q
V
K
K
A
F
F
A
L
V
T
N
G
V
R
A
A
P
L
W
D
S
K
K
Q
S
F
V
G
M
L
T
I
T
D
F
I
N
I
L
H
R
Y
Y
K
S
A
L
V
Q
I
Y
E
L
E
E
H
K
I
E
T
W
R
E
V
Y
L
Q
D
S
F
K
P
L
V
C
I
S
P
N
A
S
L
F
D
A
V
S
S
L
I
R
N
K
I
H
R
L
P
V
I
D
P
E
S
G
N
T
L
Y
I
L
T
H
K
R
I
L
K
F
L
K
L
F
I
T
-------
M
S
K
S
L
E
E
L
Q
I
G
T
Y
A
N
I
A
M
V
R
T
T
T
P
V
Y
V
A
L
G
I
F
V
Q
H
R
V
S
A
L
P
V
V
D
E
K
G
R
V
V
D
I
Y
S
K
F
D
V
I
N
L
A
A
E
K
T
Y
N
N
L
D
V
S
V
T
K
A
L
Q
H
R
-------
L
K
C
Y
L
H
E
T
L
E
A
I
I
N
R
L
V
E
A
E
V
H
R
L
V
V
V
D
E
H
D
V
V
K
G
I
V
S
L
S
D
I
L
Q
A
L
V
--------
17
PsiBlast_PDB
87.58
96%
-212
- C1 -
-
4QFS
1
AAKG1_RAT
C:
[28-322]
----------------------------
Y
T
T
F
M
K
S
H
R
C
Y
D
L
I
P
T
S
S
K
L
V
V
F
D
T
S
L
Q
V
K
K
A
F
F
A
L
V
T
N
G
V
R
A
A
P
L
W
D
S
K
K
Q
S
F
V
G
M
L
T
I
T
D
F
I
N
I
L
H
R
Y
Y
K
S
A
L
V
Q
I
Y
E
L
E
E
H
K
I
E
T
W
R
E
V
Y
L
Q
D
S
F
K
P
L
V
C
I
S
P
N
A
S
L
F
D
A
V
S
S
L
I
R
N
K
I
H
R
L
P
V
I
D
P
E
S
G
N
T
L
Y
I
L
T
H
K
R
I
L
K
F
L
K
L
F
I
T
----------
S
L
E
E
L
Q
I
------
A
M
V
R
T
T
T
P
V
Y
V
A
L
G
I
F
V
Q
H
R
V
S
A
L
P
V
V
D
E
K
G
R
V
V
D
I
Y
S
K
F
D
V
I
N
L
A
A
E
K
T
Y
N
N
L
D
V
S
V
T
K
A
L
Q
H
R
-------
L
K
C
Y
L
H
E
T
L
E
A
I
I
N
R
L
V
E
A
E
V
H
R
L
V
-----
D
V
V
K
G
I
V
S
L
S
D
I
L
Q
A
L
V
--------
24
Fugue
58.23
99%
-169
- C1 -
-
2UV4
1
A:
[8-150]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
E
F
P
K
P
E
F
M
S
K
S
L
E
E
L
Q
I
G
T
Y
A
N
I
A
M
V
R
T
T
T
P
V
Y
V
A
L
G
I
F
V
Q
H
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A
L
P
V
V
D
E
K
G
R
V
V
D
I
Y
S
K
F
D
V
I
N
L
A
A
E
K
T
Y
N
N
L
D
V
S
V
T
K
A
L
Q
H
R
S
H
Y
F
E
G
V
L
K
C
Y
L
H
E
T
L
E
T
I
I
N
R
L
V
E
A
E
V
H
R
L
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V
V
D
E
N
D
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V
K
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S
D
I
L
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A
L
V
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