@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : AAKG2_HUMAN: (2018-07-12 )
MGSAVMDTKKKKDVSSPGGSGGKKNASQKRRSLRVHIPDLSSFAMPLLDGDLEGSGKHSSRKVDSPFGPGSPSKGFFSRGPQPRPSSPMSAPVRPKTSPGSPKTVFPFSYQESPPRSPRRMSFSGIFRSSSKESSPNSNPATSPGGIRFFSRSRKTSGLSSSPSTPTQVTKQHTFPLESYKHEPERLENRIYASSSPPDTGQRFCPSSFQSPTRPPLASPTHYAPSKAAALAAALGPAEAGMLEKLEFEDEAVEDSESGVYMRFMRSHKCYDIVPTSSKLVVFDTTLQVKKAFFALVANGVRAAPLWESKKQSFVGMLTITDFINILHRYYKSPMVQIYELEEHKIETWRELYLQETFKPLVNISPDASLFDAVYSLIKNKIHRLPVIDPISGNALYILTHKRILKFLQLFMSDMPKPAFMKQNLDELGIGTYHNIAFIHPDTPIIKALNIFVERRISALPVVDESGKVVDIYSKFDVINLAAEKTYNNLDITVTQALQHRSQYFEGVVKCNKLEILETIVDRIVRAEVHRLVVVNEADSIVGIISLSDILQALILTPAGAKQKETETE
Atome Classification :
(24 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MGSAVMDTKKKKDVSSPGGSGGKK
N
A
S
Q
K
R
R
S
L
R
V
HIP
D
L
S
S
F
A
M
P
L
LDGDLEGSGKHSSRKVDSPFGPGSPSKGFFSRGPQPRPSSPMSAPVRPKTSPGSP
K
T
V
F
P
FSYQESPPRSPRRM
S
F
S
G
I
FRSSSKESSPNSNPATSPG
G
I
R
F
F
SRSRKTSGLSSSPSTP
T
Q
V
T
KQHTF
P
L
E
S
YKH
E
P
E
R
L
E
N
R
I
YASSSPPDTGQRFCPSSFQSPTRPPLASPTHYAP
S
K
A
A
A
L
A
A
ALGP
A
E
A
G
M
L
E
K
LEFEDEAVEDSES
G
V
Y
M
R
F
M
R
SHK
C
Y
D
IVPTS
S
K
L
V
V
F
DT
T
L
Q
V
K
K
A
F
F
A
L
V
ANGVRAAP
L
W
E
S
K
K
Q
S
F
V
G
M
L
T
I
T
D
F
I
N
I
L
H
R
Y
Y
KSP
M
V
Q
I
Y
E
L
E
E
H
K
I
E
T
W
R
E
L
Y
L
Q
E
T
F
K
P
L
VNISP
D
A
S
L
F
D
A
V
Y
S
L
I
K
N
K
I
HRLPVIDPISG
N
A
L
Y
I
L
T
H
K
R
I
L
K
F
L
Q
L
F
M
S
DMPK
P
A
F
M
K
Q
N
L
D
E
LGIGTY
H
N
I
A
F
IHPD
T
P
I
I
K
A
L
N
I
F
V
E
R
RISALPVVDESG
K
V
V
D
I
YSKF
D
V
I
N
L
A
A
E
KTYNNLD
I
T
V
T
Q
A
L
Q
H
R
S
Q
Y
F
E
G
V
V
KC
N
K
L
E
I
L
E
T
I
V
D
R
I
V
R
A
E
V
H
R
L
V
V
VNEAD
S
I
V
G
I
I
S
L
S
D
I
L
Q
A
L
ILTPAGAKQKETETE
3
PsiBlast_PDB
96.56
75%
-200
- C1 -
-
5ISO
3
AAKG1_HUMAN
E:
[27-324]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Y
T
S
F
M
K
S
H
R
C
Y
D
L
I
P
T
S
S
K
L
V
V
F
D
T
S
L
Q
V
K
K
A
F
F
A
L
V
T
N
G
V
R
A
A
P
L
W
D
S
K
K
Q
S
F
V
G
M
L
T
I
T
D
F
I
N
I
L
H
R
Y
Y
K
S
A
L
V
Q
I
Y
E
L
E
E
H
K
I
E
T
W
R
E
V
Y
L
Q
D
S
F
K
P
L
V
C
I
S
P
N
A
S
L
F
D
A
V
S
S
L
I
R
N
K
I
H
R
L
P
V
I
D
P
E
S
G
N
T
L
Y
I
L
T
H
K
R
I
L
K
F
L
K
L
F
I
T
E
F
P
K
P
E
F
M
S
K
S
L
E
E
L
Q
I
G
T
Y
A
N
I
A
M
V
R
T
T
T
P
V
Y
V
A
L
G
I
F
V
Q
H
R
V
S
A
L
P
V
V
D
E
K
G
R
V
V
D
I
Y
S
K
F
D
V
I
N
L
A
A
E
K
T
Y
N
N
L
D
V
S
V
T
K
A
L
Q
H
R
S
H
Y
F
E
G
V
L
K
C
Y
L
H
E
T
L
E
T
I
I
N
R
L
V
E
A
E
V
H
R
L
V
V
V
D
E
N
D
V
V
K
G
I
V
S
L
S
D
I
L
Q
A
L
V
L
-------------
4
PsiBlast_PDB
96.22
75%
-204
- C1 -
-
4ZHX
2
AAKG1_HUMAN
E:
[32-329]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Y
T
S
F
M
K
S
H
R
C
Y
D
L
I
P
T
S
S
K
L
V
V
F
D
T
S
L
Q
V
K
K
A
F
F
A
L
V
T
N
G
V
R
A
A
P
L
W
D
S
K
K
Q
S
F
V
G
M
L
T
I
T
D
F
I
N
I
L
H
R
Y
Y
K
S
A
L
V
Q
I
Y
E
L
E
E
H
K
I
E
T
W
R
E
V
Y
L
Q
D
S
F
K
P
L
V
C
I
S
P
N
A
S
L
F
D
A
V
S
S
L
I
R
N
K
I
H
R
L
P
V
I
D
P
E
S
G
N
T
L
Y
I
L
T
H
K
R
I
L
K
F
L
K
L
F
I
T
E
F
P
K
P
E
F
M
S
K
S
L
E
E
L
Q
I
G
T
Y
A
N
I
A
M
V
R
T
T
T
P
V
Y
V
A
L
G
I
F
V
Q
H
R
V
S
A
L
P
V
V
D
E
K
G
R
V
V
D
I
Y
S
K
F
D
V
I
N
L
A
A
E
K
T
Y
N
N
L
D
V
S
V
T
K
A
L
Q
H
R
S
H
Y
F
E
G
V
L
K
C
Y
L
H
E
T
L
E
T
I
I
N
R
L
V
E
A
E
V
H
R
L
V
V
V
D
E
N
D
V
V
K
G
I
V
S
L
S
D
I
L
Q
A
L
V
L
-------------
11
PsiBlast_PDB
95.43
75%
-198
- C1 -
-
2YA3
3
AAKG1_RAT
E:
[25-324]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
V
Y
T
T
F
M
K
S
H
R
C
Y
D
L
I
P
T
S
S
K
L
V
V
F
D
T
S
L
Q
V
K
K
A
F
F
A
L
V
T
N
G
V
R
A
A
P
L
W
D
S
K
K
Q
S
F
V
G
M
L
T
I
T
D
F
I
N
I
L
H
R
Y
Y
K
S
A
L
V
Q
I
Y
E
L
E
E
H
K
I
E
T
W
R
E
V
Y
L
Q
D
S
F
K
P
L
V
C
I
S
P
N
A
S
L
F
D
A
V
S
S
L
I
R
N
K
I
H
R
L
P
V
I
D
P
E
S
G
N
T
L
Y
I
L
T
H
K
R
I
L
K
F
L
K
L
F
I
T
E
F
P
K
P
E
F
M
S
K
S
L
E
E
L
Q
I
G
T
Y
A
N
I
A
M
V
R
T
T
T
P
V
Y
V
A
L
G
I
F
V
Q
H
R
V
S
A
L
P
V
V
D
E
K
G
R
V
V
D
I
Y
S
K
F
D
V
I
N
L
A
A
E
K
T
Y
N
N
L
D
V
S
V
T
K
A
L
Q
H
R
S
H
Y
F
E
G
V
L
K
C
Y
L
H
E
T
L
E
A
I
I
N
R
L
V
E
A
E
V
H
R
L
V
V
V
D
E
H
D
V
V
K
G
I
V
S
L
S
D
I
L
Q
A
L
V
L
T
------------
22
HHSearch
94.95
77%
-195
- C1 -
-
4REW
3
AAKG1_HUMAN
G:
[3-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
V
Y
T
S
F
M
K
S
H
R
C
Y
D
L
I
P
T
S
S
K
L
V
V
F
D
T
S
L
Q
V
K
K
A
F
F
A
L
V
T
N
G
V
R
A
A
P
L
W
D
S
K
K
Q
S
F
V
G
M
L
T
I
T
D
F
I
N
I
L
H
R
Y
Y
K
S
A
L
V
Q
I
Y
E
L
E
E
H
K
I
E
T
W
R
E
V
Y
L
Q
D
S
F
K
P
L
V
C
I
S
P
N
A
S
L
F
D
A
V
S
S
L
I
R
N
K
I
H
R
L
P
V
I
D
P
E
S
G
N
T
L
Y
I
L
T
H
K
R
I
L
K
F
L
K
L
F
I
T
E
F
P
K
P
E
F
M
S
K
S
L
E
E
L
Q
I
G
T
Y
A
N
I
A
M
V
R
T
T
T
P
V
Y
V
A
L
G
I
F
V
Q
H
R
V
S
A
L
P
V
V
D
E
K
G
R
V
V
D
I
Y
S
K
F
D
V
I
N
L
A
A
E
K
T
Y
N
N
L
D
V
S
V
T
K
A
L
Q
H
R
S
H
Y
F
E
G
V
L
K
C
Y
L
H
E
T
L
E
T
I
I
N
R
L
V
E
A
E
V
H
R
L
V
V
V
D
E
N
D
V
V
K
G
I
V
S
L
S
D
I
L
Q
A
L
V
L
T
------------
20
PsiBlast_PDB
94.89
75%
-202
- C1 -
-
5UFU
3
AAKG1_RAT
C:
[26-322]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Y
T
T
F
M
K
S
H
R
C
Y
D
L
I
P
T
S
S
K
L
V
V
F
D
T
S
L
Q
V
K
K
A
F
F
A
L
V
T
N
G
V
R
A
A
P
L
W
D
S
K
K
Q
S
F
V
G
M
L
T
I
T
D
F
I
N
I
L
H
R
Y
Y
K
S
A
L
V
Q
I
Y
E
L
E
E
H
K
I
E
T
W
R
E
V
Y
L
Q
D
---
P
L
V
C
I
S
P
N
A
S
L
F
D
A
V
S
S
L
I
R
N
K
I
H
R
L
P
V
I
D
P
E
S
G
N
T
L
Y
I
L
T
H
K
R
I
L
K
F
L
K
L
F
I
T
E
F
P
K
P
E
F
M
S
K
S
L
E
E
L
Q
I
G
T
Y
A
N
I
A
M
V
R
T
T
T
P
V
Y
V
A
L
G
I
F
V
Q
H
R
V
S
A
L
P
V
V
D
E
K
G
R
V
V
D
I
Y
S
K
F
D
V
I
N
L
A
A
E
K
T
Y
N
N
L
D
V
S
V
T
K
A
L
Q
H
R
-----
G
V
L
K
C
Y
L
H
E
T
L
E
A
I
I
N
R
L
V
E
A
E
V
H
R
L
V
V
V
D
E
H
D
V
V
K
G
I
V
S
L
S
D
I
L
Q
A
L
V
--------------
9
PsiBlast_PDB
94.54
75%
-196
- C1 -
-
2Y8L
3
AAKG1_RAT
E:
[23-326]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
N
S
S
V
Y
T
T
F
M
K
S
H
R
C
Y
D
L
I
P
T
S
S
K
L
V
V
F
D
T
S
L
Q
V
K
K
A
F
F
A
L
V
T
N
G
V
R
A
A
P
L
W
D
S
K
K
Q
S
F
V
G
M
L
T
I
T
D
F
I
N
I
L
H
R
Y
Y
K
S
A
L
V
Q
I
Y
E
L
E
E
H
K
I
E
T
W
R
E
V
Y
L
Q
D
S
F
K
P
L
V
C
I
S
P
N
A
S
L
F
D
A
V
S
S
L
I
R
N
K
I
H
R
L
P
V
I
D
P
E
S
G
N
T
L
Y
I
L
T
H
K
R
I
L
K
F
L
K
L
F
I
T
E
F
P
K
P
E
F
M
S
K
S
L
E
E
L
Q
I
G
T
Y
A
N
I
A
M
V
R
T
T
T
P
V
Y
V
A
L
G
I
F
V
Q
H
R
V
S
A
L
P
V
V
D
E
K
G
R
V
V
D
I
Y
S
K
F
D
V
I
N
L
A
A
E
K
T
Y
N
N
L
D
V
S
V
T
K
A
L
Q
H
R
S
H
Y
F
E
G
V
L
K
C
Y
L
H
E
T
L
E
A
I
I
N
R
L
V
E
A
E
V
H
R
L
V
V
V
D
E
H
D
V
V
K
G
I
V
S
L
S
D
I
L
Q
A
L
V
L
T
--
G
G
--------
14
PsiBlast_PDB
93.91
75%
-198
- C1 -
-
4CFH
2
AAKG1_RAT
E:
[24-324]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
S
V
Y
T
T
F
M
K
S
H
R
C
Y
D
L
I
P
T
S
S
K
L
V
V
F
D
T
S
L
Q
V
K
K
A
F
F
A
L
V
T
N
G
V
R
A
A
P
L
W
D
S
K
K
Q
S
F
V
G
M
L
T
I
T
D
F
I
N
I
L
H
R
Y
Y
K
S
A
L
V
Q
I
Y
E
L
E
E
H
K
I
E
T
W
R
E
V
Y
L
Q
D
S
F
K
P
L
V
C
I
S
P
N
A
S
L
F
D
A
V
S
S
L
I
R
N
K
I
H
R
L
P
V
I
D
P
E
S
G
N
T
L
Y
I
L
T
H
K
R
I
L
K
F
L
K
L
F
I
T
E
F
P
K
P
E
F
M
S
K
S
L
E
E
L
Q
I
G
T
Y
A
N
I
A
M
V
R
T
T
T
P
V
Y
V
A
L
G
I
F
V
Q
H
R
V
S
A
L
P
V
V
D
E
K
G
R
V
V
D
I
Y
S
K
F
D
V
I
N
L
A
A
E
K
T
Y
N
N
L
D
V
S
V
T
K
A
L
Q
H
R
S
H
Y
F
E
G
V
L
K
C
Y
L
H
E
T
L
E
A
I
I
N
R
L
V
E
A
E
V
H
R
L
V
V
V
D
E
H
D
V
V
K
G
I
V
S
L
S
D
I
L
Q
A
L
V
L
T
------------
5
PsiBlast_PDB
93.91
75%
-194
- C1 -
-
5EZV
2
AAKG1_HUMAN
E:
[29-331]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
N
N
S
V
Y
T
S
F
M
K
S
H
R
C
Y
D
L
I
P
T
S
S
K
L
V
V
F
D
T
S
L
Q
V
K
K
A
F
F
A
L
V
T
N
G
V
R
A
A
P
L
W
D
S
K
K
Q
S
F
V
G
M
L
T
I
T
D
F
I
N
I
L
H
R
Y
Y
K
S
A
L
V
Q
I
Y
E
L
E
E
H
K
I
E
T
W
R
E
V
Y
L
Q
-
S
F
K
P
L
V
C
I
S
P
N
A
S
L
F
D
A
V
S
S
L
I
R
N
K
I
H
R
L
P
V
I
D
P
E
S
G
N
T
L
Y
I
L
T
H
K
R
I
L
K
F
L
K
L
F
I
T
E
F
P
K
P
E
F
M
S
K
S
L
E
E
L
Q
I
G
T
Y
A
N
I
A
M
V
R
T
T
T
P
V
Y
V
A
L
G
I
F
V
Q
H
R
V
S
A
L
P
V
V
D
E
K
G
R
V
V
D
I
Y
S
K
F
D
V
I
N
L
A
A
E
K
T
Y
N
N
L
D
V
S
V
T
K
A
L
Q
H
R
S
H
Y
F
E
G
V
L
K
C
Y
L
H
E
T
L
E
T
I
I
N
R
L
V
E
A
E
V
H
R
L
V
V
V
D
E
N
D
V
V
K
G
I
V
S
L
S
D
I
L
Q
A
L
V
L
T
--
G
---------
8
PsiBlast_PDB
93.35
75%
-189
- C1 -
-
2V9J
3
AAKG1_RAT
E:
[23-326]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
N
S
S
V
Y
T
T
F
M
K
S
H
R
C
Y
D
L
I
P
T
S
S
K
L
V
V
F
D
T
S
L
Q
V
K
K
A
F
F
A
L
V
T
N
G
V
R
A
A
P
L
W
D
S
K
K
Q
S
F
V
G
M
L
T
I
T
D
F
I
N
I
L
H
R
Y
Y
K
S
A
L
V
Q
I
Y
E
L
E
E
H
K
I
E
T
W
R
E
V
Y
L
Q
D
S
F
K
P
L
V
C
I
S
P
N
A
S
L
F
D
A
V
S
S
L
I
R
N
K
I
H
R
L
P
V
I
D
P
E
S
G
N
T
L
Y
I
L
T
H
K
R
I
L
K
F
L
K
L
F
I
T
E
F
P
K
P
E
F
M
S
K
S
L
E
E
L
Q
I
G
T
Y
A
N
I
A
M
V
R
T
T
T
P
V
Y
V
A
L
G
I
F
V
Q
H
R
V
S
A
L
P
V
V
D
E
K
G
R
V
V
D
I
Y
S
K
F
D
V
I
N
L
A
A
E
K
T
Y
N
N
L
D
V
S
V
T
K
A
L
Q
H
R
S
H
Y
F
E
G
V
L
K
C
Y
L
H
E
T
L
E
A
I
I
N
R
L
V
E
A
E
V
H
R
L
V
V
V
D
E
H
D
V
V
K
G
I
V
S
L
S
D
I
L
Q
A
L
V
L
T
--
G
G
--------
44
Fugue
93.25
76%
-186
* C1 *
-
2V8Q
3
AAKG1_RAT
E:
[23-326]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
N
S
S
V
Y
T
T
F
M
K
S
H
R
C
Y
D
L
I
P
T
S
S
K
L
V
V
F
D
T
S
L
Q
V
K
K
A
F
F
A
L
V
T
N
G
V
R
A
A
P
L
W
D
S
K
K
Q
S
F
V
G
M
L
T
I
T
D
F
I
N
I
L
H
R
Y
Y
K
S
A
L
V
Q
I
Y
E
L
E
E
H
K
I
E
T
W
R
E
V
Y
L
Q
D
S
F
K
P
L
V
C
I
S
P
N
A
S
L
F
D
A
V
S
S
L
I
R
N
K
I
H
R
L
P
V
I
D
P
E
S
G
N
T
L
Y
I
L
T
H
K
R
I
L
K
F
L
K
L
F
I
T
E
F
P
K
P
E
F
M
S
K
S
L
E
E
L
Q
I
G
T
Y
A
N
I
A
M
V
R
T
T
T
P
V
Y
V
A
L
G
I
F
V
Q
H
R
V
S
A
L
P
V
V
D
E
K
G
R
V
V
D
I
Y
S
K
F
D
V
I
N
L
A
A
E
K
T
Y
N
N
L
D
V
S
V
T
K
A
L
Q
H
R
S
H
Y
F
E
G
V
L
K
C
Y
L
H
E
T
L
E
A
I
I
N
R
L
V
E
A
E
V
H
R
L
V
V
V
D
E
H
D
V
V
K
G
I
V
S
L
S
D
I
L
Q
A
L
V
L
T
G
G
----------
7
PsiBlast_PDB
93.23
75%
-189
- C1 -
-
2V92
3
AAKG1_RAT
E:
[23-326]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
N
S
S
V
Y
T
T
F
M
K
S
H
R
C
Y
D
L
I
P
T
S
S
K
L
V
V
F
D
T
S
L
Q
V
K
K
A
F
F
A
L
V
T
N
G
V
R
A
A
P
L
W
D
S
K
K
Q
S
F
V
G
M
L
T
I
T
D
F
I
N
I
L
H
R
Y
Y
K
S
A
L
V
Q
I
Y
E
L
E
E
H
K
I
E
T
W
R
E
V
Y
L
Q
D
S
F
K
P
L
V
C
I
S
P
N
A
S
L
F
D
A
V
S
S
L
I
R
N
K
I
H
R
L
P
V
I
D
P
E
S
G
N
T
L
Y
I
L
T
H
K
R
I
L
K
F
L
K
L
F
I
T
E
F
P
K
P
E
F
M
S
K
S
L
E
E
L
Q
I
G
T
Y
A
N
I
A
M
V
R
T
T
T
P
V
Y
V
A
L
G
I
F
V
Q
H
R
V
S
A
L
P
V
V
D
E
K
G
R
V
V
D
I
Y
S
K
F
D
V
I
N
L
A
A
E
K
T
Y
N
N
L
D
V
S
V
T
K
A
L
Q
H
R
S
H
Y
F
E
G
V
L
K
C
Y
L
H
E
T
L
E
A
I
I
N
R
L
V
E
A
E
V
H
R
L
V
V
V
D
E
H
D
V
V
K
G
I
V
S
L
S
D
I
L
Q
A
L
V
L
T
--
G
G
--------
2
PsiBlast_PDB
93.23
75%
-188
- C1 -
-
4CFF
2
AAKG1_HUMAN
E:
[27-325]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Y
T
S
F
M
K
S
H
R
C
Y
D
L
I
P
T
S
S
K
L
V
V
F
D
T
S
L
Q
V
K
K
A
F
F
A
L
V
T
N
G
V
R
A
A
P
L
W
D
S
K
K
Q
S
F
V
G
M
L
T
I
T
D
F
I
N
I
L
H
R
Y
Y
K
S
A
L
V
Q
I
Y
E
L
E
E
H
K
I
E
T
W
R
E
V
Y
L
Q
D
S
F
K
P
L
V
C
I
S
P
N
A
S
L
F
D
A
V
S
S
L
I
R
N
K
I
H
R
L
P
V
I
D
P
E
S
G
N
T
L
Y
I
L
T
H
K
R
I
L
K
F
L
K
L
F
I
T
E
F
P
K
P
E
F
M
S
K
S
L
E
E
L
Q
I
G
T
Y
A
N
I
A
M
V
R
T
T
T
P
V
Y
V
A
L
G
I
F
V
Q
H
R
V
S
A
L
P
V
V
D
E
K
G
R
V
V
D
I
Y
S
K
F
D
V
I
N
L
A
A
E
K
T
Y
N
N
L
D
V
S
V
T
K
A
L
Q
H
R
S
H
Y
F
E
G
V
L
K
C
Y
L
H
E
T
L
E
T
I
I
N
R
L
V
E
A
E
V
H
R
L
V
V
V
D
E
N
D
V
V
K
G
I
V
S
L
S
D
I
L
Q
A
L
V
L
T
------------
10
PsiBlast_PDB
92.90
75%
-184
- C1 -
-
2Y8Q
2
AAKG1_RAT
E:
[23-326]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
N
S
S
V
Y
T
T
F
M
K
S
H
R
C
Y
D
L
I
P
T
S
S
K
L
V
V
F
D
T
S
L
Q
V
K
K
A
F
F
A
L
V
T
N
G
V
R
A
A
P
L
W
D
S
K
K
Q
S
F
V
G
M
L
T
I
T
D
F
I
N
I
L
H
R
Y
Y
K
S
A
L
V
Q
I
Y
E
L
E
E
H
K
I
E
T
W
R
E
V
Y
L
Q
D
S
F
K
P
L
V
C
I
S
P
N
A
S
L
F
D
A
V
S
S
L
I
R
N
K
I
H
R
L
P
V
I
D
P
E
S
G
N
T
L
Y
I
L
T
H
K
R
I
L
K
F
L
K
L
F
I
T
E
F
P
K
P
E
F
M
S
K
S
L
E
E
L
Q
I
G
T
Y
A
N
I
A
M
V
R
T
T
T
P
V
Y
V
A
L
G
I
F
V
Q
H
R
V
S
A
L
P
V
V
D
E
K
G
R
V
V
D
I
Y
S
K
F
D
V
I
N
L
A
A
E
K
T
Y
N
N
L
D
V
S
V
T
K
A
L
Q
H
R
S
H
Y
F
E
G
V
L
K
C
Y
L
H
E
T
L
E
A
I
I
N
R
L
V
E
A
E
V
H
R
L
V
V
V
D
E
H
D
V
V
K
G
I
V
S
L
S
D
I
L
Q
A
L
V
L
T
--
G
G
--------
21
HHSearch
92.88
76%
-188
- C1 -
-
2V8Q
3
AAKG1_RAT
E:
[24-326]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
S
V
Y
T
T
F
M
K
S
H
R
C
Y
D
L
I
P
T
S
S
K
L
V
V
F
D
T
S
L
Q
V
K
K
A
F
F
A
L
V
T
N
G
V
R
A
A
P
L
W
D
S
K
K
Q
S
F
V
G
M
L
T
I
T
D
F
I
N
I
L
H
R
Y
Y
K
S
A
L
V
Q
I
Y
E
L
E
E
H
K
I
E
T
W
R
E
V
Y
L
Q
D
S
F
K
P
L
V
C
I
S
P
N
A
S
L
F
D
A
V
S
S
L
I
R
N
K
I
H
R
L
P
V
I
D
P
E
S
G
N
T
L
Y
I
L
T
H
K
R
I
L
K
F
L
K
L
F
I
T
E
F
P
K
P
E
F
M
S
K
S
L
E
E
L
Q
I
G
T
Y
A
N
I
A
M
V
R
T
T
T
P
V
Y
V
A
L
G
I
F
V
Q
H
R
V
S
A
L
P
V
V
D
E
K
G
R
V
V
D
I
Y
S
K
F
D
V
I
N
L
A
A
E
K
T
Y
N
N
L
D
V
S
V
T
K
A
L
Q
H
R
S
H
Y
F
E
G
V
L
K
C
Y
L
H
E
T
L
E
A
I
I
N
R
L
V
E
A
E
V
H
R
L
V
V
V
D
E
H
D
V
V
K
G
I
V
S
L
S
D
I
L
Q
A
L
V
L
T
G
G
----------
6
PsiBlast_PDB
92.58
75%
-186
- C1 -
-
2V8Q
3
AAKG1_RAT
E:
[23-326]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
N
S
S
V
Y
T
T
F
M
K
S
H
R
C
Y
D
L
I
P
T
S
S
K
L
V
V
F
D
T
S
L
Q
V
K
K
A
F
F
A
L
V
T
N
G
V
R
A
A
P
L
W
D
S
K
K
Q
S
F
V
G
M
L
T
I
T
D
F
I
N
I
L
H
R
Y
Y
K
S
A
L
V
Q
I
Y
E
L
E
E
H
K
I
E
T
W
R
E
V
Y
L
Q
D
S
F
K
P
L
V
C
I
S
P
N
A
S
L
F
D
A
V
S
S
L
I
R
N
K
I
H
R
L
P
V
I
D
P
E
S
G
N
T
L
Y
I
L
T
H
K
R
I
L
K
F
L
K
L
F
I
T
E
F
P
K
P
E
F
M
S
K
S
L
E
E
L
Q
I
G
T
Y
A
N
I
A
M
V
R
T
T
T
P
V
Y
V
A
L
G
I
F
V
Q
H
R
V
S
A
L
P
V
V
D
E
K
G
R
V
V
D
I
Y
S
K
F
D
V
I
N
L
A
A
E
K
T
Y
N
N
L
D
V
S
V
T
K
A
L
Q
H
R
S
H
Y
F
E
G
V
L
K
C
Y
L
H
E
T
L
E
A
I
I
N
R
L
V
E
A
E
V
H
R
L
V
V
V
D
E
H
D
V
V
K
G
I
V
S
L
S
D
I
L
Q
A
L
V
L
T
--
G
G
--------
15
PsiBlast_PDB
92.46
75%
-203
- C1 -
-
4QFG
1
AAKG1_RAT
C:
[25-322]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
V
Y
T
T
F
M
K
S
H
R
C
Y
D
L
I
P
T
S
S
K
L
V
V
F
D
T
S
L
Q
V
K
K
A
F
F
A
L
V
T
N
G
V
R
A
A
P
L
W
D
S
K
K
Q
S
F
V
G
M
L
T
I
T
D
F
I
N
I
L
H
R
Y
Y
K
S
A
L
V
Q
I
Y
E
L
E
E
H
K
I
E
T
W
R
E
V
Y
L
Q
----
P
L
V
C
I
S
P
N
A
S
L
F
D
A
V
S
S
L
I
R
N
K
I
H
R
L
P
V
I
D
P
E
S
G
N
T
L
Y
I
L
T
H
K
R
I
L
K
F
L
K
L
F
I
T
E
F
P
K
P
E
F
M
S
K
S
L
E
E
L
Q
I
G
T
Y
A
N
I
A
M
V
R
T
T
T
P
V
Y
V
A
L
G
I
F
V
Q
H
R
V
S
A
L
P
V
V
D
E
K
G
R
V
V
D
I
Y
S
K
F
D
V
I
N
L
A
A
E
K
T
Y
N
N
L
D
V
S
V
T
K
A
L
Q
H
R
-------
L
K
C
Y
L
H
E
T
L
E
A
I
I
N
R
L
V
E
A
E
V
H
R
L
V
V
V
D
E
H
D
V
V
K
G
I
V
S
L
S
D
I
L
Q
A
L
V
--------------
42
Fugue
92.20
78%
-202
- C1 -
-
4QFR
3
AAKG1_RAT
C:
[28-322]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
T
F
M
K
S
H
R
C
Y
D
L
I
P
T
S
S
K
L
V
V
F
D
T
S
L
Q
V
K
K
A
F
F
A
L
V
T
N
G
V
R
A
A
P
L
W
D
S
K
K
Q
S
F
V
G
M
L
T
I
T
D
F
I
N
I
L
H
R
Y
Y
K
S
A
L
V
Q
I
Y
E
L
E
E
H
K
I
E
T
W
R
E
V
Y
L
Q
D
S
F
K
P
L
V
C
I
S
P
N
A
S
L
F
D
A
V
S
S
L
I
R
N
K
I
H
R
L
P
V
I
D
P
E
S
G
N
T
L
Y
I
L
T
H
K
R
I
L
K
F
L
K
L
F
I
T
----------
S
L
E
E
L
Q
I
G
T
Y
A
N
I
A
M
V
R
T
T
T
P
V
Y
V
A
L
G
I
F
V
Q
H
R
V
S
A
L
P
V
V
D
E
K
G
R
V
V
D
I
Y
S
K
F
D
V
I
N
L
A
A
E
K
T
Y
N
N
L
D
V
S
V
T
K
A
L
Q
H
R
------
V
L
K
C
Y
L
H
E
T
L
E
A
I
I
N
R
L
V
E
A
E
V
H
R
L
V
V
V
D
E
H
D
V
V
K
G
I
V
S
L
S
D
I
L
Q
A
L
V
--------------
19
PsiBlast_PDB
91.80
75%
-200
- C1 -
-
5T5T
3
AAKG1_RAT
C:
[26-322]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Y
T
T
F
M
K
S
H
R
C
Y
D
L
I
P
T
S
S
K
L
V
V
F
D
T
S
L
Q
V
K
K
A
F
F
A
L
V
T
N
G
V
R
A
A
P
L
W
D
S
K
K
Q
S
F
V
G
M
L
T
I
T
D
F
I
N
I
L
H
R
Y
Y
K
S
A
L
V
Q
I
Y
E
L
E
E
H
K
I
E
T
W
R
E
V
Y
L
Q
D
S
F
K
P
L
V
C
I
S
P
N
A
S
L
F
D
A
V
S
S
L
I
R
N
K
I
H
R
L
P
V
I
D
P
E
S
G
N
T
L
Y
I
L
T
H
K
R
I
L
K
F
L
K
L
F
I
T
E
F
P
K
P
E
F
M
S
K
S
L
E
E
L
Q
I
G
T
Y
A
N
I
A
M
V
R
T
T
T
P
V
Y
V
A
L
G
I
F
V
Q
H
R
V
S
A
L
P
V
V
D
E
K
G
R
V
V
D
I
Y
S
K
F
D
V
I
N
L
A
A
E
K
T
Y
N
N
L
D
V
S
V
T
K
A
L
Q
H
R
----
E
G
V
L
K
C
Y
L
H
E
T
L
E
A
I
I
N
R
L
V
E
A
E
V
H
R
L
V
V
V
D
E
H
D
V
V
K
G
I
V
S
L
S
D
I
L
Q
A
L
V
--------------
13
PsiBlast_PDB
91.66
75%
-194
- C1 -
-
4EAL
2
AAKG1_RAT
C:
[23-324]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
N
S
S
V
Y
T
T
F
M
K
S
H
R
C
Y
D
L
I
P
T
S
S
K
L
V
V
F
D
T
S
L
Q
V
K
K
A
F
F
A
L
V
T
N
G
V
R
A
A
P
L
W
D
S
K
K
Q
S
F
V
G
M
L
T
I
T
D
F
I
N
I
L
H
R
----------
E
L
E
E
H
K
I
E
T
W
R
E
V
Y
L
Q
D
S
F
K
P
L
V
C
I
S
P
N
A
S
L
F
D
A
V
S
S
L
I
R
N
K
I
H
R
L
P
V
I
D
P
E
S
G
N
T
L
Y
I
L
T
H
K
R
I
L
K
F
L
K
L
F
I
T
E
F
P
K
P
E
F
M
S
K
S
L
E
E
L
Q
I
G
T
Y
A
N
I
A
M
V
R
T
T
T
P
V
Y
V
A
L
G
I
F
V
Q
H
R
V
S
A
L
P
V
V
D
E
K
G
R
V
V
D
I
Y
S
K
F
D
V
I
N
L
A
A
E
K
T
--
N
L
D
V
S
V
T
K
A
L
Q
H
R
S
-----
V
L
K
C
Y
L
H
E
T
L
E
A
I
I
N
R
L
V
E
A
E
V
H
R
L
V
V
V
D
E
H
D
V
V
K
G
I
V
S
L
S
D
I
L
Q
A
L
V
L
T
------------
16
PsiBlast_PDB
91.42
75%
-202
- C1 -
-
4QFR
3
AAKG1_RAT
C:
[28-322]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
T
F
M
K
S
H
R
C
Y
D
L
I
P
T
S
S
K
L
V
V
F
D
T
S
L
Q
V
K
K
A
F
F
A
L
V
T
N
G
V
R
A
A
P
L
W
D
S
K
K
Q
S
F
V
G
M
L
T
I
T
D
F
I
N
I
L
H
R
Y
Y
K
S
A
L
V
Q
I
Y
E
L
E
E
H
K
I
E
T
W
R
E
V
Y
L
Q
D
S
F
K
P
L
V
C
I
S
P
N
A
S
L
F
D
A
V
S
S
L
I
R
N
K
I
H
R
L
P
V
I
D
P
E
S
G
N
T
L
Y
I
L
T
H
K
R
I
L
K
F
L
K
L
F
I
T
----------
S
L
E
E
L
Q
I
G
T
Y
A
N
I
A
M
V
R
T
T
T
P
V
Y
V
A
L
G
I
F
V
Q
H
R
V
S
A
L
P
V
V
D
E
K
G
R
V
V
D
I
Y
S
K
F
D
V
I
N
L
A
A
E
K
T
Y
N
N
L
D
V
S
V
T
K
A
L
Q
H
R
------
V
L
K
C
Y
L
H
E
T
L
E
A
I
I
N
R
L
V
E
A
E
V
H
R
L
V
V
V
D
E
H
D
V
V
K
G
I
V
S
L
S
D
I
L
Q
A
L
V
--------------
12
PsiBlast_PDB
90.87
75%
-190
- C1 -
-
4EAK
3
AAKG1_RAT
C:
[23-324]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
N
S
S
V
Y
T
T
F
M
K
S
H
R
C
Y
D
L
I
P
T
S
S
K
L
V
V
F
D
T
S
L
Q
V
K
K
A
F
F
A
L
V
T
N
G
V
R
A
A
P
L
W
D
S
K
K
Q
S
F
V
G
M
L
T
I
T
D
F
I
N
I
L
H
R
----------
E
L
E
E
H
K
I
E
T
W
R
E
V
Y
L
Q
D
S
F
K
P
L
V
C
I
S
P
N
A
S
L
F
D
A
V
S
S
L
I
R
N
K
I
H
R
L
P
V
I
D
P
E
S
G
N
T
L
Y
I
L
T
H
K
R
I
L
K
F
L
K
L
F
I
T
E
F
P
K
P
E
F
M
S
K
S
L
E
E
L
Q
I
G
T
Y
A
N
I
A
M
V
R
T
T
T
P
V
Y
V
A
L
G
I
F
V
Q
H
R
V
S
A
L
P
V
V
D
E
K
G
R
V
V
D
I
Y
S
K
F
D
V
I
N
L
A
A
E
K
T
--
N
L
D
V
S
V
T
K
A
L
Q
H
R
S
-----
V
L
K
C
Y
L
H
E
T
L
E
A
I
I
N
R
L
V
E
A
E
V
H
R
L
V
V
V
D
E
H
D
V
V
K
G
I
V
S
L
S
D
I
L
Q
A
L
V
L
T
------------
18
PsiBlast_PDB
90.77
75%
-203
- C1 -
-
5KQ5
3
AAKG1_RAT
C:
[28-322]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
T
F
M
K
S
H
R
C
Y
D
L
I
P
T
S
S
K
L
V
V
F
D
T
S
L
Q
V
K
K
A
F
F
A
L
V
T
N
G
V
R
A
A
P
L
W
D
S
K
K
Q
S
F
V
G
M
L
T
I
T
D
F
I
N
I
L
H
R
Y
Y
K
S
A
L
V
Q
I
Y
E
L
E
E
H
K
I
E
T
W
R
E
V
Y
L
Q
D
S
F
K
P
L
V
C
I
S
P
N
A
S
L
F
D
A
V
S
S
L
I
R
N
K
I
H
R
L
P
V
I
D
P
E
S
G
N
T
L
Y
I
L
T
H
K
R
I
L
K
F
L
K
L
F
I
T
-------
M
S
K
S
L
E
E
L
Q
I
G
T
Y
A
N
I
A
M
V
R
T
T
T
P
V
Y
V
A
L
G
I
F
V
Q
H
R
V
S
A
L
P
V
V
D
E
K
G
R
V
V
D
I
Y
S
K
F
D
V
I
N
L
A
A
E
K
T
Y
N
N
L
D
V
S
V
T
K
A
L
Q
H
R
-------
L
K
C
Y
L
H
E
T
L
E
A
I
I
N
R
L
V
E
A
E
V
H
R
L
V
V
V
D
E
H
D
V
V
K
G
I
V
S
L
S
D
I
L
Q
A
L
V
--------------
17
PsiBlast_PDB
86.26
75%
-209
- C1 -
-
4QFS
1
AAKG1_RAT
C:
[28-322]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
T
F
M
K
S
H
R
C
Y
D
L
I
P
T
S
S
K
L
V
V
F
D
T
S
L
Q
V
K
K
A
F
F
A
L
V
T
N
G
V
R
A
A
P
L
W
D
S
K
K
Q
S
F
V
G
M
L
T
I
T
D
F
I
N
I
L
H
R
Y
Y
K
S
A
L
V
Q
I
Y
E
L
E
E
H
K
I
E
T
W
R
E
V
Y
L
Q
D
S
F
K
P
L
V
C
I
S
P
N
A
S
L
F
D
A
V
S
S
L
I
R
N
K
I
H
R
L
P
V
I
D
P
E
S
G
N
T
L
Y
I
L
T
H
K
R
I
L
K
F
L
K
L
F
I
T
----------
S
L
E
E
L
Q
I
------
A
M
V
R
T
T
T
P
V
Y
V
A
L
G
I
F
V
Q
H
R
V
S
A
L
P
V
V
D
E
K
G
R
V
V
D
I
Y
S
K
F
D
V
I
N
L
A
A
E
K
T
Y
N
N
L
D
V
S
V
T
K
A
L
Q
H
R
-------
L
K
C
Y
L
H
E
T
L
E
A
I
I
N
R
L
V
E
A
E
V
H
R
L
V
-----
D
V
V
K
G
I
V
S
L
S
D
I
L
Q
A
L
V
--------------
45
Fugue
56.27
69%
-165
- C1 -
-
2UV4
1
A:
[8-150]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
E
F
P
K
P
E
F
M
S
K
S
L
E
E
L
Q
I
G
T
Y
A
N
I
A
M
V
R
T
T
T
P
V
Y
V
A
L
G
I
F
V
Q
H
R
V
S
A
L
P
V
V
D
E
K
G
R
V
V
D
I
Y
S
K
F
D
V
I
N
L
A
A
E
K
T
Y
N
N
L
D
V
S
V
T
K
A
L
Q
H
R
S
H
Y
F
E
G
V
L
K
C
Y
L
H
E
T
L
E
T
I
I
N
R
L
V
E
A
E
V
H
R
L
V
V
V
D
E
N
D
V
V
K
G
I
V
S
L
S
D
I
L
Q
A
L
V
--------------