@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : CYFP1_HUMAN: (2018-07-13 )
MAAQVTLEDALSNVDLLEELPLPDQQPCIEPPPSSLLYQPNFNTNFEDRNAFVTGIARYIEQATVHSSMNEMLEEGQEYAVMLYTWRSCSRAIPQVKCNEQPNRVEIYEKTVEVLEPEVTKLMNFMYFQRNAIERFCGEVRRLCHAERRKDFVSEAYLITLGKFINMFAVLDELKNMKCSVKNDHSAYKRAAQFLRKMADPQSIQESQNLSMFLANHNKITQSLQQQLEVISGYEELLADIVNLCVDYYENRMYLTPSEKHMLLKVMGFGLYLMDGSVSNIYKLDAKKRINLSKIDKYFKQLQVVPLFGDMQIELARYIKTSAHYEENKSRWTCTSSGSSPQYNICEQMIQIREDHMRFISELARYSNSEVVTGSGRQEAQKTDAEYRKLFDLALQGLQLLSQWSAHVMEVYSWKLVHPTDKYSNKDCPDSAEEYERATRYNYTSEEKFALVEVIAMIKGLQVLMGRMESVFNHAIRHTVYAALQDFSQVTLREPLRQAIKKKKNVIQSVLQAIRKTVCDWETGHEPFNDPALRGEKDPKSGFDIKVPRRAVGPSSTQLYMVRTMLESLIADKSGSKKTLRSSLEGPTILDIEKFHRESFFYTHLINFSETLQQCCDLSQLWFREFFLELTMGRRIQFPIEMSMPWILTDHILETKEASMMEYVLYSLDLYNDSAHYALTRFNKQFLYDEIEAEVNLCFDQFVYKLADQIFAYYKVMAGSLLLDKRLRSECKNQGATIHLPPSNRYETLLKQRHVQLLGRSIDLNRLITQRVSAAMYKSLELAIGRFESEDLTSIVELDGLLEINRMTHKLLSRYLTLDGFDAMFREANHNVSAPYGRITLHVFWELNYDFLPNYCYNGSTNRFVRTVLPFSQEFQRDKQPNAQPQYLHGSKALNLAYSSIYGSYRNFVGPPHFQVICRLLGYQGIAVVMEELLKVVKSLLQGTILQYVKTLMEVMPKICRLPRHEYGSPGILEFFHHQLKDIVEYAELKTVCFQNLREVGNAILFCLLIEQSLSLEEVCDLLHAAPFQNILPRVHVKEGERLDAKMKRLESKYAPLHLVPLIERLGTPQQIAIAREGDLLTKERLCCGLSMFEVILTRIRSFLDDPIWRGPLPSNGVMHVDECVEFHRLWSAMQFVYCIPVGTHEFTVEQCFGDGLHWAGCMIIVLLGQQRRFAVLDFCYHLLKVQKHDGKDEIIKNVPLKKMVERIRKFQILNDEIITILDKYLKSGDGEGTPVEHVRCFQPPIHQSLASS
Atome Classification :
(20 SA)
------.....--------....10........20........30---------........40........50...-.....60........70--........80........90........100.......110.......120.......130.......140.....-..-150.......160.......170.......180-..--.....190.......200.......210...-....220.......230........240-------.....-....250..-.....260..-----.....270.......280..--.....290..--.....300.......310-.........320------.......330.....-----..340....-...----350.......360---.------.....-..370.......380----........390..--.....400.......410.......420.......430.......440---.......450.......460.......470.......480.......490.......500.......510.......520...--------------....530..-.....540......---.550.-......560.......570.......580.......590.......600.......610......-----.620-..---......630.......640.......650.....------..660.......670.......680.......690.......700.....--..710.......720.......730......--.740.......750.......760.......770.....--..780..-..-...-790.......800.......810.......---820.......830---------...-....840.......850--........860.......870.......880.......890.......900.......910.....-----..920...-----....930.......940.......950.......960.......970.......980.......990....--...1000......1010........-----.1020......1030......1040......1050......1060.....--.1070.....--.1080.......1090.......1100......1110-------........1120......1130......1140......1150......1160......1170......1180.---.....1190......1200......1210...-------...1220--........1230......1240......1250----------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
------MA
A
Q
V
--------
T
L
E
D
A
LS
N
V
D
L
L
E
ELPLPDQQPCIEP---------P
P
S
S
L
L
YQPNFNTNF
E
D
R
N
A
F
V
T
-
G
I
A
R
Y
I
E
Q
A
T
V
H
S
S
M
N
E
--
M
L
EEGQ
E
Y
A
V
M
L
Y
T
W
R
S
C
S
RAIP
Q
V
KCNEQPN
R
V
E
I
Y
E
K
T
V
E
VL
E
P
E
V
T
K
L
M
N
F
M
Y
F
Q
R
N
A
I
E
R
F
C
G
E
V
R
R
L
C
H
A
E
-
R
R
-
K
D
F
V
S
E
A
Y
L
I
T
L
G
K
F
I
N
M
F
A
V
L
D
E
L
K
NM
K
C
SVK-N
D
--
H
S
A
Y
K
R
A
A
Q
F
L
R
KMA
D
P
Q
S
I
Q
ESQN
L
S
M
F
L
A-N
H
N
K
I
T
Q
S
L
Q
Q
Q
L
E
V
-
I
S
G
Y
E
E
L
L
A
D
---------
I
V
N
L
C
-
V
D
Y
YEN
R
M
Y
-LTPSE
K
H
M
L
L
-----
K
V
MG
F
G
L
Y
L
MDGSVS
N
I
Y
KL--
D
A
K
KRI
N
L
S
K
--
I
D
K
Y
F
K
Q
L
Q
V
V
P
LFGD---
M
Q
I
E
L
A
R
Y
I
K
T
S------AHYEENK
S
R
W
T
CTSS-----GSSP
Q
Y
N
I
C
-
E
Q
M
----
I
Q
I
R
E
D
H
M
R
F
I
S
----
E
------
L
A
R
YS-NS
E
V
V
TGSG
R
Q
E
A
Q
-----
K
T
D
A
E
Y
R
K
L
F
D
L
A
--
L
Q
G
L
Q
L
L
S
Q
W
S
A
H
V
M
E
V
Y
S
W
K
LVHPTDKYSNKDCPD
S
A
E
E
Y
E
R
A
TRYN---YT
S
E
E
K
F
A
L
V
E
V
I
A
M
I
K
G
L
Q
V
L
M
G
R
M
E
S
V
F
N
H
A
I
R
H
T
V
Y
A
A
L
Q
D
F
S
Q
V
T
L
R
E
P
L
R
Q
A
I
K
K
K
K
N
V
I
Q
S
V
L
Q
A
I
R
K
T
VCDWETGH--------------EPFNDPALR-GEKDPKSGF
D
I
KVP---RRAVG-PSS
T
Q
L
Y
M
V
R
T
M
L
E
S
L
I
ADKSG
S
K
K
T
L
R
S
SLEG
P
T
I
L
D
I
E
K
F
H
R
E
S
F
F
Y
T
H
LI
N
F
S
E
T
L
Q
Q
C
C
D
L
-----
S
Q
L
--
W
F
---
R
E
F
F
L
E
L
TMG
R
R
I
Q
F
P
I
EMSM
P
W
I
L
T
D
H
I
LE
T
K
E
------
A
S
M
M
E
Y
V
L
Y
S
LDLYNDSA
H
Y
A
L
T
R
F
N
K
Q
F
L
Y
D
E
I
E
A
E
V
N
L
C
F
D
Q
F
V
Y
K
L
A
--
D
Q
I
F
A
Y
Y
K
V
M
A
G
S
L
L
L
D
K
R
L
R
S
E
C
KNQG
A
T
I
--HLPPS
N
R
Y
E
T
L
L
K
Q
R
H
V
Q
L
L
GRSI
D
L
N
R
L
I
T
Q
R
V
S
A
A
M
Y
--
K
S
L
E
L
A
I-GR-F
E
S
-
E
D
L
T
S
I
V
E
L
D
G
L
L
E
I
N
R
M
T
H
K
L
L
S
R
Y
LTLD---
G
F
D
A
M
F
R
EANHNV---------SAP-Y
G
R
I
T
L
H
V
F
W
E
L
N
Y
D
F---LP
N
Y
CYNGSTN
R
F
V
R
TVLP
F
S
Q
E
F
Q
RDKQPNAQPQYLHGS
K
A
L
N
L
A
Y
S
S
I
Y
G
S
Y
R
NFVGP
P
H
F
Q
V
I
-----
C
R
L
LGYQ
G
-----
I
A
V
V
M
E
E
L
L
K
V
V
K
S
L
L
Q
G
T
I
L
Q
Y
V
K
T
L
M
E
V
M
P
K
I
CRL
P
R
H
EYGSP
G
I
L
E
F
F
H
H
Q
L
K
D
I
V
E
Y
A
E
L
K
T
V
C
F
Q
N
--
L
R
E
V
G
N
A
I
L
F
C
L
L
I
---
E
QSL
S
L
E
E
-----
V
C
D
L
L
H
AA
P
F
Q
N
I
LP
R
V
HVKEG
E
R
L
D
A
K
M
K
R
L
E
SKYAP
L
H
L
V
P
L
I
E
RLGT--P
Q
Q
I
A
I
AREG--D
L
-
L
T
K
E
R
L
C
C
G
L
-
S
M
F
E
V
I
L
T
R
I
R
S
F
LDDPIWRG---------PLPSNGVM
H
V
D
E
C
V
E
F
H
R
L
W
S
A
M
Q
F
V
Y
C
I
PVGTH
E
F
T
V
E
Q
C
FGDG
L
H
W
A
G
C
M
I
I
V
L
LGQQ
R
R
F
A
V
L
D
F
C
Y
H
L
L
---
K
V
QKHD
G
K
D
E
I
I
KNV
P
L
K
K
M
V
E
R
I
R
K
F
QIL
N
D
-------
E
I
I
T
I
----
L
D
K
Y
L
KSGDGEGTPV
E
H
V
RCFQP
P
I
H
Q
S
LASS----------
3
HHSearch
69.46
100%
-144
- C3 -
-
4N78
5
CYFP1_HUMAN
A:
[5-1250]
----------
V
--------
T
L
E
D
A
L
S
N
V
D
L
L
E
E
L
P
L
------------------------------------------
G
I
A
R
Y
I
E
Q
A
T
V
H
S
S
M
N
E
--
M
L
E
E
G
Q
E
Y
A
V
M
L
Y
T
W
R
S
C
S
R
A
I
P
Q
V
K
C
N
E
Q
P
N
R
V
E
I
Y
E
K
T
V
E
V
L
E
P
E
V
T
K
L
M
N
F
M
Y
F
Q
R
N
A
I
E
R
F
C
G
E
V
R
R
L
C
H
A
E
-
R
R
-
K
D
F
V
S
E
A
Y
L
I
T
L
G
K
F
I
N
M
F
A
V
L
D
E
L
K
N
M
K
C
S
V
K
-
N
D
--
H
S
A
Y
K
R
A
A
Q
F
L
R
K
M
A
D
P
Q
S
I
Q
E
S
Q
N
L
S
M
F
L
A
-
N
H
N
K
I
T
Q
S
L
Q
Q
Q
L
E
V
-
I
S
G
Y
E
E
L
L
A
D
---------
I
V
N
L
C
-
V
D
Y
Y
E
N
R
M
Y
-
L
T
P
S
E
K
H
M
L
L
-----
K
V
M
G
F
G
L
Y
L
M
D
G
S
V
S
N
I
Y
K
L
--
D
A
K
K
R
I
N
L
S
K
--
I
D
K
Y
F
K
Q
L
Q
V
V
P
L
F
G
D
---
M
Q
I
E
L
A
R
Y
I
K
T
S
------
A
H
Y
E
E
N
K
S
R
W
T
C
T
S
S
-----
G
S
S
P
Q
Y
N
I
C
-
E
Q
M
----
I
Q
I
R
E
D
H
M
R
F
I
S
----
E
------
L
A
R
Y
S
-------------
A
Q
-----
K
T
D
A
E
Y
R
K
L
F
D
L
A
--
L
Q
G
L
Q
L
L
S
Q
W
S
A
H
V
M
E
V
Y
S
W
K
L
V
H
P
T
D
K
Y
S
N
K
D
C
P
D
S
A
E
E
Y
E
R
A
T
R
Y
N
---
Y
T
S
E
E
K
F
A
L
V
E
V
I
A
M
I
K
G
L
Q
V
L
M
G
R
M
E
S
V
F
N
H
A
I
R
H
T
V
Y
A
A
L
Q
D
F
S
Q
V
T
L
R
E
P
L
R
Q
A
I
K
K
K
K
N
V
I
Q
S
V
L
Q
A
I
R
K
T
V
C
D
W
E
T
G
H
--------------
E
P
F
N
D
P
A
L
R
-
G
E
K
D
P
---
F
D
I
K
V
P
---
R
R
A
V
G
-
P
S
S
T
Q
L
Y
M
V
R
T
M
L
E
S
L
I
A
------
K
T
L
R
S
S
L
E
G
P
T
I
L
D
I
E
K
F
H
R
E
S
F
F
Y
T
H
L
I
N
F
S
E
T
L
Q
Q
C
C
D
L
-----
S
Q
L
--
W
F
---
R
E
F
F
L
E
L
T
M
G
R
R
I
Q
F
P
I
E
M
S
M
P
W
I
L
T
D
H
I
L
E
T
K
E
------
A
S
M
M
E
Y
V
L
Y
S
L
D
L
Y
N
D
S
A
H
Y
A
L
T
R
F
N
K
Q
F
L
Y
D
E
I
E
A
E
V
N
L
C
F
D
Q
F
V
Y
K
L
A
--
D
Q
I
F
A
Y
Y
K
V
M
A
G
S
L
L
L
D
K
R
L
R
S
E
C
K
N
Q
G
A
T
I
--
H
L
P
P
S
N
R
Y
E
T
L
L
K
Q
R
H
V
Q
L
L
G
R
S
I
D
L
N
R
L
I
T
Q
R
V
S
A
A
M
Y
--
K
S
L
E
L
A
I
-
G
R
-
F
E
S
-
E
D
L
T
S
I
V
E
L
D
G
L
L
E
I
N
R
M
T
H
K
L
L
S
R
Y
L
T
L
D
---
G
F
D
A
M
F
R
E
A
N
H
N
V
---------
S
A
P
-
Y
G
R
I
T
L
H
V
F
W
E
L
N
Y
D
F
---
L
P
N
Y
C
Y
N
G
S
T
N
R
F
V
R
T
V
L
P
F
S
Q
E
F
Q
R
D
K
Q
P
N
A
Q
P
Q
Y
L
H
G
S
K
A
L
N
L
A
Y
S
S
I
Y
G
S
Y
R
N
F
V
G
P
P
H
F
Q
V
I
-----
C
R
L
L
G
Y
Q
G
-----
I
A
V
V
M
E
E
L
L
K
V
V
K
S
L
L
Q
G
T
I
L
Q
Y
V
K
T
L
M
E
V
M
P
K
I
C
R
L
P
R
H
E
Y
G
S
P
G
I
L
E
F
F
H
H
Q
L
K
D
I
V
E
Y
A
E
L
K
T
V
C
F
Q
N
--
L
R
E
V
G
N
A
I
L
F
C
L
L
I
---
E
Q
S
L
S
L
E
E
-----
V
C
D
L
L
H
A
A
P
F
Q
N
I
L
P
R
V
H
V
K
E
G
E
R
L
D
A
K
M
K
R
L
E
S
K
Y
A
P
L
H
L
V
P
L
I
E
R
L
G
T
--
P
Q
Q
I
A
I
A
R
E
G
--
D
L
-
L
T
K
E
R
L
C
C
G
L
-
S
M
F
E
V
I
L
T
R
I
R
S
F
L
D
D
P
I
W
R
G
---------
P
L
P
S
N
G
V
M
H
V
D
E
C
V
E
F
H
R
L
W
S
A
M
Q
F
V
Y
C
I
P
V
G
T
H
E
F
T
V
E
Q
C
F
G
D
G
L
H
W
A
G
C
M
I
I
V
L
L
G
Q
Q
R
R
F
A
V
L
D
F
C
Y
H
L
L
---
K
V
Q
K
H
D
G
K
D
E
I
I
K
N
V
P
L
K
K
M
V
E
R
I
R
K
F
Q
I
L
N
D
-------
E
I
I
T
I
----
L
D
K
Y
L
K
---------
E
H
V
R
C
F
Q
P
P
I
H
Q
S
L
-------------
2
PsiBlast_PDB
69.46
100%
-144
- C3 -
-
4N78
5
CYFP1_HUMAN
A:
[5-1250]
----------
V
--------
T
L
E
D
A
L
S
N
V
D
L
L
E
E
L
P
L
------------------------------------------
G
I
A
R
Y
I
E
Q
A
T
V
H
S
S
M
N
E
--
M
L
E
E
G
Q
E
Y
A
V
M
L
Y
T
W
R
S
C
S
R
A
I
P
Q
V
K
C
N
E
Q
P
N
R
V
E
I
Y
E
K
T
V
E
V
L
E
P
E
V
T
K
L
M
N
F
M
Y
F
Q
R
N
A
I
E
R
F
C
G
E
V
R
R
L
C
H
A
E
-
R
R
-
K
D
F
V
S
E
A
Y
L
I
T
L
G
K
F
I
N
M
F
A
V
L
D
E
L
K
N
M
K
C
S
V
K
-
N
D
--
H
S
A
Y
K
R
A
A
Q
F
L
R
K
M
A
D
P
Q
S
I
Q
E
S
Q
N
L
S
M
F
L
A
-
N
H
N
K
I
T
Q
S
L
Q
Q
Q
L
E
V
-
I
S
G
Y
E
E
L
L
A
D
---------
I
V
N
L
C
-
V
D
Y
Y
E
N
R
M
Y
-
L
T
P
S
E
K
H
M
L
L
-----
K
V
M
G
F
G
L
Y
L
M
D
G
S
V
S
N
I
Y
K
L
--
D
A
K
K
R
I
N
L
S
K
--
I
D
K
Y
F
K
Q
L
Q
V
V
P
L
F
G
D
---
M
Q
I
E
L
A
R
Y
I
K
T
S
------
A
H
Y
E
E
N
K
S
R
W
T
C
T
S
S
-----
G
S
S
P
Q
Y
N
I
C
-
E
Q
M
----
I
Q
I
R
E
D
H
M
R
F
I
S
----
E
------
L
A
R
Y
S
-------------
A
Q
-----
K
T
D
A
E
Y
R
K
L
F
D
L
A
--
L
Q
G
L
Q
L
L
S
Q
W
S
A
H
V
M
E
V
Y
S
W
K
L
V
H
P
T
D
K
Y
S
N
K
D
C
P
D
S
A
E
E
Y
E
R
A
T
R
Y
N
---
Y
T
S
E
E
K
F
A
L
V
E
V
I
A
M
I
K
G
L
Q
V
L
M
G
R
M
E
S
V
F
N
H
A
I
R
H
T
V
Y
A
A
L
Q
D
F
S
Q
V
T
L
R
E
P
L
R
Q
A
I
K
K
K
K
N
V
I
Q
S
V
L
Q
A
I
R
K
T
V
C
D
W
E
T
G
H
--------------
E
P
F
N
D
P
A
L
R
-
G
E
K
D
P
---
F
D
I
K
V
P
---
R
R
A
V
G
-
P
S
S
T
Q
L
Y
M
V
R
T
M
L
E
S
L
I
A
------
K
T
L
R
S
S
L
E
G
P
T
I
L
D
I
E
K
F
H
R
E
S
F
F
Y
T
H
L
I
N
F
S
E
T
L
Q
Q
C
C
D
L
-----
S
Q
L
--
W
F
---
R
E
F
F
L
E
L
T
M
G
R
R
I
Q
F
P
I
E
M
S
M
P
W
I
L
T
D
H
I
L
E
T
K
E
------
A
S
M
M
E
Y
V
L
Y
S
L
D
L
Y
N
D
S
A
H
Y
A
L
T
R
F
N
K
Q
F
L
Y
D
E
I
E
A
E
V
N
L
C
F
D
Q
F
V
Y
K
L
A
--
D
Q
I
F
A
Y
Y
K
V
M
A
G
S
L
L
L
D
K
R
L
R
S
E
C
K
N
Q
G
A
T
I
--
H
L
P
P
S
N
R
Y
E
T
L
L
K
Q
R
H
V
Q
L
L
G
R
S
I
D
L
N
R
L
I
T
Q
R
V
S
A
A
M
Y
--
K
S
L
E
L
A
I
-
G
R
-
F
E
S
-
E
D
L
T
S
I
V
E
L
D
G
L
L
E
I
N
R
M
T
H
K
L
L
S
R
Y
L
T
L
D
---
G
F
D
A
M
F
R
E
A
N
H
N
V
---------
S
A
P
-
Y
G
R
I
T
L
H
V
F
W
E
L
N
Y
D
F
---
L
P
N
Y
C
Y
N
G
S
T
N
R
F
V
R
T
V
L
P
F
S
Q
E
F
Q
R
D
K
Q
P
N
A
Q
P
Q
Y
L
H
G
S
K
A
L
N
L
A
Y
S
S
I
Y
G
S
Y
R
N
F
V
G
P
P
H
F
Q
V
I
-----
C
R
L
L
G
Y
Q
G
-----
I
A
V
V
M
E
E
L
L
K
V
V
K
S
L
L
Q
G
T
I
L
Q
Y
V
K
T
L
M
E
V
M
P
K
I
C
R
L
P
R
H
E
Y
G
S
P
G
I
L
E
F
F
H
H
Q
L
K
D
I
V
E
Y
A
E
L
K
T
V
C
F
Q
N
--
L
R
E
V
G
N
A
I
L
F
C
L
L
I
---
E
Q
S
L
S
L
E
E
-----
V
C
D
L
L
H
A
A
P
F
Q
N
I
L
P
R
V
H
V
K
E
G
E
R
L
D
A
K
M
K
R
L
E
S
K
Y
A
P
L
H
L
V
P
L
I
E
R
L
G
T
--
P
Q
Q
I
A
I
A
R
E
G
--
D
L
-
L
T
K
E
R
L
C
C
G
L
-
S
M
F
E
V
I
L
T
R
I
R
S
F
L
D
D
P
I
W
R
G
---------
P
L
P
S
N
G
V
M
H
V
D
E
C
V
E
F
H
R
L
W
S
A
M
Q
F
V
Y
C
I
P
V
G
T
H
E
F
T
V
E
Q
C
F
G
D
G
L
H
W
A
G
C
M
I
I
V
L
L
G
Q
Q
R
R
F
A
V
L
D
F
C
Y
H
L
L
---
K
V
Q
K
H
D
G
K
D
E
I
I
K
N
V
P
L
K
K
M
V
E
R
I
R
K
F
Q
I
L
N
D
-------
E
I
I
T
I
----
L
D
K
Y
L
K
---------
E
H
V
R
C
F
Q
P
P
I
H
Q
S
L
-------------
4
HHSearch
68.79
100%
-148
- C3 -
-
3P8C
4
CYFP1_HUMAN
A:
[5-1250]
----------
V
--------
T
L
E
D
A
L
S
N
V
D
L
L
E
E
L
P
L
--------------------------------------------
A
R
Y
I
E
Q
A
T
V
H
S
S
M
N
E
--
M
L
E
E
G
Q
E
Y
A
V
M
L
Y
T
W
R
S
C
S
R
A
I
P
Q
V
K
C
N
E
Q
P
N
R
V
E
I
Y
E
K
T
V
E
V
L
E
P
E
V
T
K
L
M
N
F
M
Y
F
Q
R
N
A
I
E
R
F
C
G
E
V
R
R
L
C
H
A
E
-
R
R
-
K
D
F
V
S
E
A
Y
L
I
T
L
G
K
F
I
N
M
F
A
V
L
D
E
L
K
N
M
K
C
S
V
K
-
N
D
--
H
S
A
Y
K
R
A
A
Q
F
L
R
K
M
A
D
P
Q
S
I
Q
E
S
Q
N
L
S
M
F
L
A
-
N
H
N
K
I
T
Q
S
L
Q
Q
Q
L
E
V
-
I
S
G
Y
E
E
L
L
A
D
---------
I
V
N
L
C
-
V
D
Y
Y
E
N
R
M
Y
-
L
T
P
S
E
K
H
M
L
L
-----
K
V
M
G
F
G
L
Y
L
M
D
G
S
V
S
N
I
Y
K
L
--
D
A
K
K
R
I
N
L
S
K
--
I
D
K
Y
F
K
Q
L
Q
V
V
P
L
F
G
D
---
M
Q
I
E
L
A
R
Y
I
K
T
S
------
A
H
Y
E
E
N
K
S
R
W
T
C
T
S
S
------------
I
C
-
E
Q
M
----
I
Q
I
R
E
D
H
M
R
F
I
S
----
E
------
L
A
R
Y
S
-------------
A
Q
-----
K
T
D
A
E
Y
R
K
L
F
D
L
A
--
L
Q
G
L
Q
L
L
S
Q
W
S
A
H
V
M
E
V
Y
S
W
K
L
V
H
P
T
D
K
Y
S
N
K
D
C
P
D
S
A
E
E
Y
E
R
A
T
R
Y
N
---
Y
T
S
E
E
K
F
A
L
V
E
V
I
A
M
I
K
G
L
Q
V
L
M
G
R
M
E
S
V
F
N
H
A
I
R
H
T
V
Y
A
A
L
Q
D
F
S
Q
V
T
L
R
E
P
L
R
Q
A
I
K
K
K
K
N
V
I
Q
S
V
L
Q
A
I
R
K
T
V
C
D
W
E
T
G
H
--------------
E
P
F
N
D
P
A
L
R
-
G
E
K
D
P
---
F
D
I
K
V
P
---
R
R
A
V
G
-
P
S
S
T
Q
L
Y
M
V
R
T
M
L
E
S
L
I
A
------
K
T
L
R
S
S
L
E
G
P
T
I
L
D
I
E
K
F
H
R
E
S
F
F
Y
T
H
L
I
N
F
S
E
T
L
Q
Q
C
C
D
L
-----
S
Q
L
--
W
F
---
R
E
F
F
L
E
L
T
M
G
R
R
I
Q
F
P
I
E
M
S
M
P
W
I
L
T
D
H
I
L
E
T
K
E
------
A
S
M
M
E
Y
V
L
Y
S
L
D
L
Y
N
D
S
A
H
Y
A
L
T
R
F
N
K
Q
F
L
Y
D
E
I
E
A
E
V
N
L
C
F
D
Q
F
V
Y
K
L
A
--
D
Q
I
F
A
Y
Y
K
V
M
A
G
S
L
L
L
D
K
R
L
R
S
E
C
K
N
Q
G
A
T
I
--
H
L
P
P
S
N
R
Y
E
T
L
L
K
Q
R
H
V
Q
L
L
G
R
S
I
D
L
N
R
L
I
T
Q
R
V
S
A
A
M
Y
--
K
S
L
E
L
A
I
-
G
R
-
F
E
S
-
E
D
L
T
S
I
V
E
L
D
G
L
L
E
I
N
R
M
T
H
K
L
L
S
R
Y
L
T
L
D
---
G
F
D
A
M
F
R
E
A
N
H
N
V
---------
S
A
P
-
Y
G
R
I
T
L
H
V
F
W
E
L
N
Y
D
F
---
L
P
N
Y
C
Y
N
G
S
T
N
R
F
V
R
T
V
L
P
F
S
Q
E
F
Q
R
D
K
Q
P
N
A
Q
P
Q
Y
L
H
G
S
K
A
L
N
L
A
Y
S
S
I
Y
G
S
Y
R
N
F
V
G
P
P
H
F
Q
V
I
-----
C
R
L
L
G
Y
Q
G
-----
I
A
V
V
M
E
E
L
L
K
V
V
K
S
L
L
Q
G
T
I
L
Q
Y
V
K
T
L
M
E
V
M
P
K
I
C
R
L
P
R
H
E
Y
G
S
P
G
I
L
E
F
F
H
H
Q
L
K
D
I
V
E
Y
A
E
L
K
T
V
C
F
Q
N
--
L
R
E
V
G
N
A
I
L
F
C
L
L
I
---
E
Q
S
L
S
L
E
E
-----
V
C
D
L
L
H
A
A
P
F
Q
N
I
L
P
R
V
H
V
K
E
G
E
R
L
D
A
K
M
K
R
L
E
S
K
Y
A
P
L
H
L
V
P
L
I
E
R
L
G
T
--
P
Q
Q
I
A
I
A
R
E
G
--
D
L
-
L
T
K
E
R
L
C
C
G
L
-
S
M
F
E
V
I
L
T
R
I
R
S
F
L
D
D
P
I
W
R
G
---------
P
L
P
S
N
G
V
M
H
V
D
E
C
V
E
F
H
R
L
W
S
A
M
Q
F
V
Y
C
I
P
V
G
T
H
E
F
T
V
E
Q
C
F
G
D
G
L
H
W
A
G
C
M
I
I
V
L
L
G
Q
Q
R
R
F
A
V
L
D
F
C
Y
H
L
L
---
K
V
Q
K
H
D
G
K
D
E
I
I
K
N
V
P
L
K
K
M
V
E
R
I
R
K
F
Q
I
L
N
D
-------
E
I
I
T
I
----
L
D
K
Y
L
K
---------
E
H
V
R
C
F
Q
P
P
I
H
Q
S
L
-------------
1
PsiBlast_PDB
68.79
100%
-148
- C3 -
-
3P8C
4
CYFP1_HUMAN
A:
[5-1250]
----------
V
--------
T
L
E
D
A
L
S
N
V
D
L
L
E
E
L
P
L
--------------------------------------------
A
R
Y
I
E
Q
A
T
V
H
S
S
M
N
E
--
M
L
E
E
G
Q
E
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L
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M
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------------
I
C
-
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----
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----
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------
L
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-------------
A
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L
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--------------
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K
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W
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---
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---
G
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---------
P
L
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S
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G
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M
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V
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---
K
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-------
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----
L
D
K
Y
L
K
---------
E
H
V
R
C
F
Q
P
P
I
H
Q
S
L
-------------
13
Fugue
63.17
97%
-26
- C3 -
-
3P8C
4
CYFP1_HUMAN
A:
[5-1250]
--------------------------------------------------------------
V
T
L
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D
A
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L
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---------
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----
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-----
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---
Y
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C
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--------------
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---
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M
L
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L
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------
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Q
Q
C
C
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-----
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W
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---
R
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F
F
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L
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M
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M
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M
P
W
I
L
T
D
H
I
L
E
T
K
E
------
A
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M
M
E
Y
V
L
Y
S
L
D
L
Y
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D
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A
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Y
A
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A
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L
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R
Y
L
T
L
D
---
G
F
D
A
M
F
R
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A
N
H
N
V
---------
S
A
P
-
Y
G
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L
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W
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L
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D
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---
L
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K
A
L
N
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A
Y
S
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Y
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N
F
V
G
P
P
H
F
Q
V
I
-----
C
R
L
L
G
Y
Q
G
-----
I
A
V
V
M
E
E
L
L
K
V
V
K
S
L
L
Q
G
T
I
L
Q
Y
V
K
T
L
M
E
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M
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L
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H
E
Y
G
S
P
G
I
L
E
F
F
H
H
Q
L
K
D
I
V
E
Y
A
E
L
K
T
V
C
F
Q
N
--
L
R
E
V
G
N
A
I
L
F
C
L
L
I
---
E
Q
S
L
S
L
E
E
-----
V
C
D
L
L
H
A
A
P
F
Q
N
I
L
P
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V
H
V
K
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A
K
M
K
R
L
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K
Y
A
P
L
H
L
V
P
L
I
E
R
L
G
T
--
P
Q
Q
I
A
I
A
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G
--
D
L
-
L
T
K
E
R
L
C
C
G
L
-
S
M
F
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V
I
L
T
R
I
R
S
F
L
D
D
P
I
W
R
G
---------
P
L
P
S
N
G
V
M
H
V
D
E
C
V
E
F
H
R
L
W
S
A
M
Q
F
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Y
C
I
P
V
G
T
H
E
F
T
V
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Q
C
F
G
D
G
L
H
W
A
G
C
M
I
I
V
L
L
G
Q
Q
R
R
F
A
V
L
D
F
C
Y
H
L
L
---
K
V
Q
K
H
D
G
K
D
E
I
I
K
N
V
P
L
K
K
M
V
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R
I
R
K
F
Q
I
L
N
D
-------
E
I
I
T
I
----
L
D
K
Y
L
K
E
---------
H
V
R
C
F
Q
P
P
I
H
Q
S
L
-------------
12
HHSearch
40.37
28%
-424
- C6 -
-
3IHF
-
B2CL1_MOUSE
B:
[127-144]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
N
E
L
F
R
D
G
V
N
W
G
A
I
V
A
F
F
---------------------------------------------------------------------------------------------------------------
15
Fugue
29.79
20%
14
- C4 -
-
5IKY
-
?
A:
[2-1106]
V
K
T
F
Y
I
T
A
A
P
V
GA
V
P
K
F
L
D
P
L
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P
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A
L
L
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L
L
P
A
D
R
R
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A
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A
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A
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G
W
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A
V
P
A
G
G
I
V
R
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Y
G
Y
D
A
P
I
D
L
T
D
Y
----------
A
S
A
T
V
H
D
A
L
R
N
N
G
W
T
P
S
G
S
V
W
H
R
---
T
Q
T
S
P
S
L
A
Q
P
P
L
I
T
R
N
T
L
E
R
L
----
S
S
V
D
L
V
R
Q
I
V
L
Q
L
T
T
F
G
W
T
A
T
E
D
-----
G
S
L
T
W
--
A
H
D
-
R
I
-
H
T
Y
L
S
P
D
F
V
E
R
M
R
A
D
N
A
--
A
V
L
D
S
L
F
E
N
G
W
--------------------
R
M
C
G
A
G
H
W
Q
P
G
K
A
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S
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L
P
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T
A
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G
I
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D
A
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E
A
L
R
---
E
G
-----
A
A
---------
V
V
H
L
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-
T
R
----------
A
T
D
D
Q
A
T
L
-----
A
I
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L
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-----------------
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------
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R
R
A
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-------------
S
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---------------
L
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----
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AQLAPD
V
A
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-
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A
G
G
--------------------------
G
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---
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---
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----------------
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-----------------------------------------
L
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-------------
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------
A
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---
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------
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H
L
A
--
S
A
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-------
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A
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-----
H
E
Y
L
V
A
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Y
I
--------
Q
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Q
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N
--
F
A
R
E
L
L
V
-------------------------------
P
R
G
Y
S
I
E
---
A
Y
D
R
A
L
E
D
Y
S
Y
S
V
---------
R
V
D
Q
F
K
P
L
P
L
R
C
L
E
Y
L
V
--
G
---
I
P
-
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R
Y
N
S
D
Y
S
N
V
V
N
L
G
L
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-----
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A
T
M
A
L
L
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A
L
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N
A
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K
A
C
G
P
------------------------
L
W
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R
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V
A
P
D
E
L
A
A
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W
V
V
L
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S
T
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T
T
N
Y
P
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R
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V
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---
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N
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A
L
N
A
DPSGI
Y
F
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L
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I
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T
A
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Q
L
--
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Q
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C
R
D
G
E
R
L
G
L
-
T
-----
G
D
E
L
R
A
F
F
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R
A
L
L
V
S
F
GSAADIHL
D
W
L
G
T
S
V
V
D
V
T
A
F
N
D
V
R
S
L
A
G
T
T
S
R
H
Y
V
I
Q
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H
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D
V
L
Q
H
C
L
V
H
T
------------------
Q
P
A
D
Y
R
Y
D
H
A
---
T
P
V
W
Q
D
G
R
Q
G
--------
K
I
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R
L
T
G
V
F
L
L
D
D
-------
H
A
R
L
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DGHS
I
R
R
Y
L
A
A
------
S
P
L
W
L
R
Q
W
I
A
R
F
H
D
A
P
A
D
T
G
A
H
A
I
L
R
E
LQ
18
Fugue
29.34
13%
-33
- C4 -
-
5DLQ
1
XPO4_MOUSE
A:
[9-1107]
------
P
E
V
I
A
--------
Q
L
E
N
A
A
K
V
L
---------------
M
A
---------
P
P
S
M
V
--------
S
N
E
Q
R
Q
H
A
E
H
-
I
F
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C
R
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--
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A
A
T
A
I
M
E
A
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V
R
----------------------------
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W
V
L
L
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L
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F
L
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L
Q
K
Y
V
R
E
Q
I
L
L
A
V
A
V
I
V
K
R
-
G
S
L
D
K
S
I
D
C
K
----------
S
I
F
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Q
L
I
S
S
G
N
P
T
V
Q
T
L
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A
L
L
S
-
E
F
S
S
F
H
G
N
C
K
R
V
F
Q
E
--
E
D
L
R
Q
I
F
M
L
---------
T
V
G
V
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-
Q
E
F
S
R
-
R
E
N
-
L
S
A
Q
M
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F
Q
-----
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Y
L
A
L
A
N
Q
V
L
S
W
N
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--
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A
L
L
D
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--
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K
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S
D
---
M
A
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L
Q
C
L
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------
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---------------------
S
L
H
G
P
I
F
-
P
D
E
----
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Q
V
D
Y
L
A
H
F
I
E
----
G
------
L
L
N
T
I
-
N
G
------------------
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E
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D
S
E
A
V
G
I
S
--
S
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L
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T
V
F
P
R
N
V
L
T
-------------------------------
A
---
I
P
S
E
L
F
S
S
F
V
N
C
L
T
H
L
T
C
S
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G
R
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A
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E
V
L
D
D
M
V
Y
M
E
A
Y
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L
L
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W
L
T
L
V
R
D
D
K
G
F
F
T
Q
H
A
V
Q
V
F
N
S
Y
I
Q
C
--------------------------------------------------------------------------
H
L
A
A
P
D
G
T
R
N
-----
L
T
E
E
E
I
S
E
L
Q
E
D
D
R
D
Q
F
---------------------------------
S
D
Q
L
A
S
V
G
M
L
G
R
I
-----------
A
A
E
H
C
M
P
L
L
T
------
S
L
L
E
E
R
V
T
R
M
L
D
D
L
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G
Y
L
L
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----------
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--
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I
M
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S
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---------
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T
L
Q
I
--
L
G
S
P
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------
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T
D
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L
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--
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S
R
A
I
R
---------
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D
L
T
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L
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Q
M
G
K
D
I
V
W
F
L
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R
W
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Y
L
L
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D
-----
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K
L
Y
D
Q
I
S
L
P
L
---------
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T
A
-
F
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A
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T
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G
S
Q
W
I
I
G
Y
L
L
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S
V
W
S
S
E
Q
D
L
A
N
D
T
V
Q
L
L
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L
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-
E
R
R
E
R
A
N
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L
A
K
Q
F
A
S
R
S
P
P
L
N
F
L
S
S
P
V
Q
R
T
L
-----
M
K
A
L
V
L
G
G
FWTEV
L
Q
P
L
Q
Q
R
F
L
R
V
I
Q
Q
M
C
Q
Q
--
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E
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Q
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I
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A
T
L
E
A
L
C
G
I
A
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A
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V
A
I
L
F
N
F
L
M
D
F
L
N
N
C
I
G
L
M
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----
Y
K
N
--
T
P
E
T
V
N
L
I
I
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V
F
V
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V
A
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K
Q
I
C
Y
L
G
E
-----
S
K
A
M
H
L
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E
A
C
L
T
L
L
Q
V
Y
S
K
N
N
L
G
R
Q
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V
T
A
E
E
E
Q
Y
Q
D
L
L
L
I
M
E
L
L
T
N
L
L
--
A
D
V
V
L
Y
G
V
N
L
I
L
P
L
-
M
S
Q
D
-----
L
-
L
K
F
P
T
L
C
N
Q
Y
Y
K
L
I
T
F
I
C
E
I
F
---------
P
E
K
I
P
Q
L
L
F
K
S
L
M
Y
S
L
E
L
G
M
T
S
M
S
----------------------
S
E
V
C
Q
L
C
L
E
A
L
T
P
L
A
F
L
A
T
R
H
F
L
K
L
V
F
---
D
M
L
V
T
T
A
A
G
E
A
F
Y
T
L
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C
Q
A
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Y
S
E
L
V
E
T
L
L
S
S
Q
-------
Q
D
P
V
I
----
Y
Q
R
L
A
D
A
F
N
K
L
T
A
S
S
K
M
A
F
L
K
S
L
E
E
F
M
A
N
V
G
-----------
11
HHSearch
27.32
33%
-177
* C6 *
-
3ILC
-
B2CL1_MOUSE
A:
[127-141]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
N
E
L
F
R
D
G
V
N
W
G
R
I
V
------------------------------------------------------------------------------------------------------------------
14
Fugue
21.93
10%
-32
- C3 -
-
3P8C
1
NCKP1_HUMAN
B:
[7-1121]
------------------------------------------------------
Q
P
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----
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L
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L
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--------------
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K
A
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L
Y
N
Y
A
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R
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Q
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L
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------------------
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L
A
L
-----
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----
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------
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-----
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H
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R
R
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L
--
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L
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--
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L
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A
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N
M
---
P
K
K
S
A
D
D
F
I
D
------
K
H
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A
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L
I
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Y
M
E
E
L
R
A
H
V
R
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--
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C
P
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D
E
S
I
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M
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S
F
V
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--------------
T
S
L
S
V
K
Q
V
E
-
D
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F
----------------------
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---
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---
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L
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K
P
S
E
L
L
T
S
V
R
A
Y
M
T
V
L
Q
S
I
E
N
Y
V
Q
I
D
---
I
T
R
V
F
N
N
V
L
L
Q
Q
T
---------
Q
H
L
-
D
S
H
G
E
P
T
I
T
S
L
Y
T
N
W
Y
---
L
E
T
L
L
R
Q
V
S
N
G
H
I
A
Y
F
--
P
A
M
K
A
F
V
N
L
P
T
E
N
E
L
T
F
-----------------
N
A
E
E
Y
S
D
I
S
E
M
R
S
L
-----
S
E
L
L
G
P
Y
G
-----
M
K
F
L
S
E
S
L
M
W
H
I
S
S
Q
V
A
-
E
L
K
K
L
V
V
E
N
V
D
V
L
T
Q
M
R
T
S
F
D
K
-----------
P
D
Q
M
A
A
L
F
K
R
L
S
S
V
D
S
V
L
K
R
--
M
T
I
I
G
V
I
L
S
F
R
S
L
A
---
Q
E
A
L
R
D
V
L
-----
S
Y
H
I
--
P
F
L
V
S
S
I
E
D
F
K
D
H
D
M
K
V
A
M
N
V
Y
E
L
S
S
A
A
G
L
P
C
E
I
D
P
A
L
V
V
A
L
-----------
S
S
S
--
P
E
-
E
E
Y
K
I
A
C
L
L
M
-
V
F
V
A
V
S
L
P
T
L
A
S
N
V
M
S
Q
Y
S
P
------------
A
I
E
G
H
C
N
-----
N
I
H
C
L
A
K
A
I
N
Q
I
A
A
A
L
F
T
I
H
K
G
S
I
E
D
R
L
K
E
F
L
A
L
A
S
S
S
L
L
K
I
--------------------------------
G
Q
E
T
D
K
T
T
T
R
N
R
E
S
V
Y
L
L
L
D
-------
M
I
V
Q
E
----
S
P
F
L
T
M
D
L
L
E
S
C
F
P
Y
V
L
L
R
N
A
Y
H
A
V
Y
K
---------------
5
HHSearch
18.51
13%
1
- C3 -
-
3P8C
1
NCKP1_HUMAN
B:
[691-937]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
V
P
N
M
V
V
W
E
H
T
F
T
P
R
E
Y
L
T
S
H
L
E
I
R
F
T
--
K
S
I
V
G
M
T
-
M
Y
N
Q
A
T
-
Q
E
I
A
K
P
S
E
L
L
T
S
V
R
A
Y
M
T
V
L
Q
S
I
E
N
Y
V
Q
I
D
I
T
R
V
F
N
N
V
L
L
Q
Q
T
Q
H
L
DSHGEPT
I
T
S
L
Y
-
T
N
W
Y
L
E
T
L
L
R
Q
V
S
N
------
G
H
I
A
Y
F
P
A
M
K
A
F
V
N
L
----------
P
T
E
N
---------
E
L
T
F
N
---------
A
E
E
Y
S
D
I
S
E
M
R
S
L
-----
S
E
L
L
G
P
Y
G
-----
M
K
F
L
S
E
S
L
M
W
H
I
S
S
Q
V
A
E
-
L
K
K
L
V
V
E
N
V
D
V
L
T
Q
M
----
R
T
S
F
D
K
P
D
Q
---
M
A
A
L
F
K
R
L
S
---
S
V
-
D
S
V
L
K
R
--
M
T
I
I
G
V
I
L
S
F
R
S
L
A
---
Q
E
A
L
R
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
HHSearch
18.35
13%
-90
- C3 -
-
1NKZ
3
LHB5_RHOAC
D:
[3-17]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
A
E
Q
S
E
E
L
H
K
Y
V
I
D
------------------------------------------------------------------------------------------------------------------------------------------------
6
HHSearch
18.31
41%
108
* C5 *
-
5MRV
-
MCPI_NERVS
C:
[2-18]
----------------------------------
H
V
P
D
D
R
P
C
I
N
P
---------
G
R
C
P
L
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
Fugue
18.06
15%
-15
- C3 -
-
4XDN
-
SCC4_YEAST
A:
[24-640]
--------------------------------------------------------
G
D
K
L
S
I
S
Q
V
Y
H
L
A
Q
E
Y
R
D
H
A
Y
-
S
I
A
N
K
I
G
S
E
E
G
L
K
Q
Y
Y
G
--
L
M
N
M
S
I
Q
M
F
Q
L
L
K
T
K
C
T
L
S
----------
V
L
E
D
S
K
V
T
F
E
M
V
E
L
L
I
Q
E
--------
T
Y
N
F
D
L
A
E
L
Y
I
S
S
L
K
E
R
L
Q
T
H
-
Q
S
-
D
T
D
L
V
E
E
I
M
R
C
------
E
F
L
L
L
H
D
L
P
L
M
R
D
S
K
F
-
H
Y
--
K
I
A
L
R
N
C
N
E
L
V
Q
Y
M
V
N
L
Q
D
E
L
Y
Q
N
W
A
S
V
F
Q
Y
-
V
G
V
M
L
C
I
K
L
K
Q
H
R
R
V
-
K
T
S
F
H
G
L
L
S
Q
CREKS
Q
W
K
W
F
L
N
L
C
Y
V
N
Y
L
L
N
E
R
F
-
P
I
P
E
D
A
L
Q
E
L
R
S
TEL
H
T
V
G
P
E
L
Y
A
W
K
L
A
L
E
M
V
I
Q
L
C
K
D
G
N
I
T
D
H
L
N
E
--
F
K
N
F
F
D
T
N
K
Q
S
L
V
T
N
E
GKG
C
V
I
K
I
M
P
R
I
A
L
K
V
E
L
PMI
F
H
Y
K
E
L
K
N
I
L
L
L
L
Q
S
-----
V
S
Y
I
V
N
C
Y
D
-
E
K
G
----
N
F
S
R
K
F
L
P
K
V
Y
S
----
T
------
T
Q
K
L
I
-
K
N
I
A
A
G
G
V
S
M
N
E
L
D
-----
S
R
I
Q
T
Y
K
S
I
L
E
F
C
E
F
Y
K
V
W
E
Q
T
L
L
K
G
A
V
V
L
G
P
S
P
G
Y
V
R
L
L
Q
A
M
K
V
Q
F
E
G
G
G
A
V
E
E
Y
T
R
L
A
Q
S
G
---
G
T
S
----
S
E
V
K
M
I
S
L
L
N
C
Y
T
V
Q
A
A
R
V
S
R
C
S
G
D
K
Q
G
E
L
V
E
Q
C
N
K
V
W
L
Q
V
---
E
K
L
L
Q
E
T
D
L
Q
F
N
P
I
W
E
C
T
V
T
I
L
W
L
F
S
H
F
E
------------------
P
F
S
W
N
P
L
P
-
C
S
D
K
Q
R
A
E
Y
V
S
K
L
R
---
E
F
Y
S
S
N
K
F
V
N
R
F
K
L
K
K
A
L
L
L
Q
I
L
V
N
Y
L
G
G
R
M
L
E
H
D
------
L
G
E
I
Y
A
I
S
A
K
C
F
D
M
C
R
Q
Q
G
G
M
R
K
V
Q
Y
V
I
G
I
W
H
L
M
N
C
T
V
--
A
M
---
R
G
K
D
V
A
L
T
N
A
K
L
E
A
L
V
K
Q
I
T
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
Fugue
15.66
16%
-6
- C4 -
-
4JSP
1
MTOR_HUMAN
A:
[10-1174]
---------------------
E
R
A
A
K
C
R
A
Y
A
K
A
L
H
Y
K
E
L
E
F
Q
K
G
P
---------
T
P
A
I
L
E
S
L
I
S
I
N
N
K
L
Q
Q
P
E
A
A
A
G
-
V
L
E
Y
A
M
K
H
F
G
E
L
E
I
Q
A
T
--
W
Y
E
K
L
H
E
W
E
D
A
L
V
A
Y
D
K
K
M
D
T
--------
N
K
D
D
P
E
L
M
L
G
R
M
R
C
L
E
A
L
---------
G
E
W
G
Q
L
H
Q
Q
C
C
E
K
W
T
L
V
N
D
E
-
T
Q
-
A
K
M
A
R
M
A
A
A
A
A
W
G
-----
L
G
Q
W
D
S
M
E
E
Y
T
C
M
I
P
-
R
D
T
H
D
G
A
F
Y
R
A
V
L
A
L
H
Q
----------
D
L
F
S
L
A
Q
Q
-
C
I
D
K
A
R
D
L
L
D
A
E
L
T
A
-
M
A
G
E
S
Y
------------------------
S
R
A
Y
-
G
A
M
V
S
C
H
M
L
S
-----
E
L
E
E
V
I
Q
Y
K
L
V
P
E
R
R
E
I
I
R
Q
--
I
W
W
E
R
L
Q
G
C
Q
R
I
V
E
D
W
Q
K
I
L
M
V
R
S
L
V
V
S
---
P
H
E
D
M
R
T
W
L
K
Y
A
------
S
L
C
G
K
S
G
R
L
A
L
A
H
K
T
L
V
L
L
L
G
V
D
P
S
R
Q
L
D
-
H
P
L
P
TVH
P
Q
V
T
Y
A
Y
M
K
N
M
W
K
S
AR
K
------
I
D
A
F
Q
-
H
M
Q
H
F
V
Q
T
M
Q
Q
Q
A
Q
HAIAT
E
D
Q
Q
H
K
Q
E
L
H
K
L
M
--
A
R
C
F
L
K
L
G
E
W
Q
L
N
L
Q
G
I
------------
N
E
S
T
I
P
K
V
L
Q
Y
Y
S
A
A
T
E
H
D
RSW
Y
K
A
W
H
A
W
A
V
M
N
F
E
A
V
L
H
Y
K
H
Q
N
Q
A
R
D
E
---
K
K
K
V
T
E
D
L
S
K
T
L
L
M
Y
T
V
P
A
V
Q
G
F
F
R
S
I
S
L
S
R
G
N
N
L
Q
D
T
L
R
V
L
T
---
L
W
F
D
Y
G
H
--------------
W
P
D
V
N
E
A
L
V
-
E
G
V
K
A
---------------------
I
Q
I
D
T
W
L
Q
V
I
P
Q
L
I
A
-
R
I
D
T
P
R
P
L
V
G
R
L
I
H
Q
L
L
T
D
I
G
R
Y
H
P
Q
A
L
I
Y
P
L
T
V
A
S
K
S
T
T
------------------------------
T
A
R
H
N
A
A
N
K
I
L
K
N
M
C
E
H
S
N
T
L
V
Q
Q
A
------
M
M
V
S
E
E
L
I
R
V
A
I
L
W
H
E
M
W
H
E
G
L
E
E
A
S
R
L
Y
F
G
E
R
N
V
K
G
M
F
E
V
L
E
P
L
H
A
M
M
E
RG
P
Q
T
L
K
E
T
S
F
N
Q
A
Y
G
R
D
L
M
E
A
Q
E
W
C
R
K
Y
M
K
S
G
--
N
V
K
D
L
T
Q
A
W
D
L
Y
Y
H
V
F
R
R
I
S
K
Q
L
P
Q
L
T
S
L
E
L
Q
Y
V
S
P
K
L
L
M
C
R
D
L
E
L
A
V
P
G
T
-
Y
D
P
N
Q
P
I
I
R
I
Q
S
I
A
P
S
L
Q
V
--
I
T
S
K
Q
R
P
R
K
L
T
L
M
---
G
-----------------------------------------------------
S
N
G
H
E
F
V
F
L
L
K
G
H
E
-----
D
L
R
Q
D
E
R
V
M
Q
L
F
G
L
V
N
T
L
L
A
N
D
P
T
S
L
R
K
N
L
S
I
Q
R
Y
A
V
I
P
LSTN
S
G
L
I
G
W
V
P
-----
H
C
D
T
L
H
A
L
I
R
D
Y
R
E
K
-
K
K
I
L
L
N
I
E
H
R
I
M
L
R
M
A
------------
P
D
Y
D
H
L
T
L
M
Q
K
V
E
V
F
E
H
A
V
N
N
T
----------------------------
A
G
D
D
-----
L
A
K
L
L
W
L
K
S
----------
P
S
S
E
V
W
F
D
R
R
T
N
Y
T
R
S
L
A
V
M
S
M
V
G
Y
I
L
G
L
G
D
RH
P
S
N
L
M
L
D
R
-------
L
S
G
K
I
L
H
I
D
F
G
D
C
F
E
V
A
M
T
R
-------
E
K
F
P
E
---------
K
I
P
-------------
F
R
L
T
R
M
L
T
N
A
-----------
M
E
V
T
G
L
D
G
N
Y
R
I
T
C
H
T
V
M
E
V
L
R
E
H
K
D
S
V
M
A
V
L
E
A
F
V
Y
DP
L
L
N
W
R
L
M
D
T
N
T
A
L
N
K
K
A
I
Q
I
I
N
R
V
R
D
K
L
T
G
R
D
FSHDDTL
D
V
P
T
Q
----
V
E
L
L
I
K
Q
A
T
S
H
E
N
L
C
Q
C
Y
I
G
W
C
P
F
W
-----------------
7
HHSearch
14.84
41%
108
- C5 -
-
4A94
-
MCPI_NERVS
C:
[3-18]
-----------------------------------
V
P
D
D
R
P
C
I
N
P
---------
G
R
C
P
L
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
Fugue
12.22
14%
23
* C4 *
-
3N6O
-
DRRA_LEGPH
A:
[1-303]
------------------------------------------------------------------------
G
H
M
V
T
-
R
I
E
N
L
E
N
A
K
K
L
W
D
N
A
N
S
--
M
L
E
K
G
-
N
I
S
G
Y
L
K
A
A
N
E
L
H
K
F
M
K
E
K
N
L
K
E
D
D
L
R
P
E
L
S
D
K
T
I
S
---
P
K
G
Y
A
I
L
Q
S
L
W
---
G
A
A
S
D
Y
S
R
A
A
A
T
L
T
E
S
T
-
V
E
-
P
G
L
V
S
A
V
N
K
M
S
-
A
F
F
M
D
C
K
L
S
P
N
E
R
A
T
P
D
P
D
F
K
V
G
K
--
S
K
I
L
V
G
I
M
Q
F
I
K
D
V
A
D
P
T
S
K
I
W
M
H
N
T
K
A
L
M
N
-
H
K
I
A
A
I
Q
K
L
E
R
S
N
N
V
N
D
E
T
L
E
S
V
L
S
S
---------
K
G
E
N
L
-
S
E
Y
L
S
Y
K
Y
A
-
T
K
D
E
G
R
E
H
R
Y
-----
T
A
S
T
E
N
F
K
N
V
K
E
K
Y
Q
Q
M
R
G
---
D
A
L
K
T
E
I
L
A
D
--
F
K
D
K
L
A
E
A
T
D
E
Q
S
L
K
Q
---
I
V
A
E
L
K
S
----
K
------
D
E
Y
R
I
L
A
K
G
Q
G
L
T
T
Q
-----
L
L
G
L
K
T
S
S
V
-
S
S
F
----
E
K
M
V
E
E
T
R
E
S
I
K
----
S
------
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
HHSearch
10.60
23%
-162
- C1 -
-
2BBG
-
A:
[1-22]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
G
L
C
Y
E
G
T
N
----
C
G
K
V
G
K
Y
C
C
S
P
I
--------------------------------------------------------------------------------------------------
10
HHSearch
9.95
50%
90
- C- -
-
1MIJ
-
A:
[1281-1312]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
N
N
T
-----
A
Q
L
V
K
W
F
S
N
F
R
E
F
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
Fugue
9.78
34%
102
* C3 *
-
3CBA
2
?
H:
[2-26]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
E
A
A
E
K
A
A
K
Y
A
---
A
E
A
A
E
K
A
A
K
A
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------