@TOME V2.3
(Mar 2018)
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : KEAP1_HUMAN: (2018-07-13 )
MQPDPRPSGAGACCRFLPLQSQCPEGAGDAVMYASTECKAEVTPSQHGNRTFSYTLEDHTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDYLVKIFEELTLHKPTQVMPCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSGRSGVGVAVTMEPCRKQIDQQNCTC
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620..
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MQPDPRPSGA
G
A
C
C
RFLPLQSQCPEGAG
D
A
V
M
Y
ASTEC
K
A
EVTPSQHG
N
R
T
F
S
Y
T
L
E
DH
T
K
Q
A
F
G
I
M
N
E
L
R
L
S
Q
Q
LC
D
V
T
L
Q
V
K
YQDA
P
A
A
Q
F
M
A
H
K
V
V
LASSS
P
V
F
K
A
M
F
TN
G
L
R
EQG
M
E
V
V
S
IEGI
H
P
K
V
M
E
R
L
I
E
F
A
Y
TASISM
G
E
K
C
V
L
H
VMNG
A
V
M
Y
Q
I
D
S
V
V
R
A
C
S
D
F
L
V
Q
QLDPSNAI
G
I
A
N
F
A
E
Q
I
G
C
V
E
L
H
Q
R
A
R
E
Y
I
Y
M
H
F
G
E
V
A
K
Q
E
E
FFNLS
H
C
Q
L
V
T
L
I
SRDDL
N
V
R
C
E
S
E
V
F
H
A
C
I
N
W
V
KY
D
C
E
Q
R
R
F
Y
V
Q
A
L
L
R
A
V
R
CHSL
T
P
N
F
L
Q
M
Q
L
Q
K
C
E
I
LQSD
S
R
C
K
D
Y
L
V
K
I
F
E
E
L
TLHKPTQVMPCRAPKV
G
R
L
I
Y
TA
G
G
Y
F
R
Q
S
L
S
Y
L
E
AYNPSDG
T
W
L
R
L
A
DLQVPRSG
L
A
G
C
V
V
G
G
L
L
Y
AVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRI
G
V
G
V
IDG
H
I
Y
A
VGGSHGCIHHN
S
V
ERYEPERD
E
W
H
L
V
A
P
M
L
T
R
RI
G
V
G
V
A
V
L
N
R
L
L
Y
A
VGGFDGTNRLNSA
E
C
YYPERN
E
W
R
M
I
T
A
M
N
T
I
RSGA
G
V
C
V
L
H
N
C
I
YAAGGYDG
Q
D
Q
LNSV
E
R
Y
DVETE
T
W
T
F
V
A
P
M
K
HRRSAL
G
I
T
V
HQ
G
R
I
Y
V
L
GGYDGH
T
F
L
D
S
V
E
CYDPDTD
T
W
S
E
V
T
R
MTSGRSG
V
G
V
A
V
T
M
E
P
C
R
K
Q
I
D
QQNCTC
9
PsiBlast_PDB
75.12
96%
-95
- C2 -
-
5FNS
1
A:
[5-293]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
R
L
I
Y
T
A
G
G
Y
F
R
Q
S
L
S
Y
L
E
A
Y
N
P
S
N
G
S
W
L
R
L
A
D
L
Q
V
P
R
S
G
L
A
G
C
V
V
G
G
L
L
Y
A
V
G
G
R
N
N
S
P
D
G
N
T
D
S
S
A
L
D
C
Y
N
P
M
T
N
Q
W
S
P
C
A
S
M
S
V
P
R
N
R
I
G
V
G
V
I
D
G
H
I
Y
A
V
G
G
S
H
G
C
I
H
H
S
S
V
E
R
Y
E
P
E
R
D
E
W
H
L
V
A
P
M
L
T
R
R
I
G
V
G
V
A
V
L
N
R
L
L
Y
A
V
G
G
F
D
G
T
N
R
L
N
S
A
E
C
Y
Y
P
E
R
N
E
W
R
M
I
T
P
M
N
T
I
R
S
G
A
G
V
C
V
L
H
N
C
I
Y
A
A
G
G
Y
D
G
Q
D
Q
L
N
S
V
E
R
Y
D
V
E
T
E
T
W
T
F
V
A
P
M
R
H
H
R
S
A
L
G
I
T
V
H
Q
G
K
I
Y
V
L
G
G
Y
D
G
H
T
F
L
D
S
V
E
C
Y
D
P
D
S
D
T
W
S
E
V
T
R
M
T
S
G
R
S
G
V
G
V
A
V
T
M
E
P
C
-----------
10
PsiBlast_PDB
74.54
96%
-96
- C2 -
-
5FNT
1
A:
[5-293]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
R
L
I
Y
T
A
G
G
Y
F
R
Q
S
L
S
Y
L
E
A
Y
N
P
S
N
G
S
W
L
R
L
A
D
L
Q
V
P
R
S
G
L
A
G
C
V
V
G
G
L
L
Y
A
V
G
G
R
N
N
S
P
D
G
N
T
D
S
S
A
L
D
C
Y
N
P
M
T
N
Q
W
S
P
C
A
S
M
S
V
P
R
N
R
I
G
V
G
V
I
D
G
H
I
Y
A
V
G
G
S
H
G
C
I
H
H
S
S
V
E
R
Y
E
P
E
R
D
E
W
H
L
V
A
P
M
L
T
R
R
I
G
V
G
V
A
V
L
N
R
L
L
Y
A
V
G
G
F
D
G
T
N
R
L
N
S
A
E
C
Y
Y
P
E
R
N
E
W
R
M
I
T
P
M
N
T
I
R
S
G
A
G
V
C
V
L
H
N
C
I
Y
A
A
G
G
Y
D
G
Q
D
Q
L
N
S
V
E
R
Y
D
V
E
T
E
T
W
T
F
V
A
P
M
R
H
H
R
S
A
L
G
I
T
V
H
Q
G
K
I
Y
V
L
G
G
Y
D
G
H
T
F
L
D
S
V
E
C
Y
D
P
D
S
D
T
W
S
E
V
T
R
M
T
S
G
R
S
G
V
G
V
A
V
T
M
E
P
C
-----------
12
PsiBlast_PDB
74.48
96%
-96
- C2 -
-
5FZJ
1
A:
[5-293]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
R
L
I
Y
T
A
G
G
Y
F
R
Q
S
L
S
Y
L
E
A
Y
N
P
S
N
G
S
W
L
R
L
A
D
L
Q
V
P
R
S
G
L
A
G
C
V
V
G
G
L
L
Y
A
V
G
G
R
N
N
S
P
D
G
N
T
D
S
S
A
L
D
C
Y
N
P
M
T
N
Q
W
S
P
C
A
S
M
S
V
P
R
N
R
I
G
V
G
V
I
D
G
H
I
Y
A
V
G
G
S
H
G
C
I
H
H
S
S
V
E
R
Y
E
P
E
R
D
E
W
H
L
V
A
P
M
L
T
R
R
I
G
V
G
V
A
V
L
N
R
L
L
Y
A
V
G
G
F
D
G
T
N
R
L
N
S
A
E
C
Y
Y
P
E
R
N
E
W
R
M
I
T
P
M
N
T
I
R
S
G
A
G
V
C
V
L
H
N
C
I
Y
A
A
G
G
Y
D
G
Q
D
Q
L
N
S
V
E
R
Y
D
V
E
T
E
T
W
T
F
V
A
P
M
R
H
H
R
S
A
L
G
I
T
V
H
Q
G
K
I
Y
V
L
G
G
Y
D
G
H
T
F
L
D
S
V
E
C
Y
D
P
D
S
D
T
W
S
E
V
T
R
M
T
S
G
R
S
G
V
G
V
A
V
T
M
E
P
C
-----------
3
PsiBlast_PDB
74.43
96%
-97
- C2 -
-
2Z32
-
A:
[17-306]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
G
R
L
I
Y
T
A
G
G
Y
F
R
Q
S
L
S
Y
L
E
A
Y
N
P
S
N
G
S
W
L
R
L
A
D
L
Q
V
P
R
S
G
L
A
G
C
V
V
G
G
L
L
Y
A
V
G
G
R
N
N
S
P
D
G
N
T
D
S
S
A
L
D
C
Y
N
P
M
T
N
Q
W
S
P
C
A
S
M
S
V
P
R
N
R
I
G
V
G
V
I
D
G
H
I
Y
A
V
G
G
S
H
G
C
I
H
H
S
S
V
E
R
Y
E
P
E
R
D
E
W
H
L
V
A
P
M
L
T
R
R
I
G
V
G
V
A
V
L
N
R
L
L
Y
A
V
G
G
F
D
G
T
N
R
L
N
S
A
E
C
Y
Y
P
E
R
N
E
W
R
M
I
T
P
M
N
T
I
R
S
G
A
G
V
C
V
L
H
N
C
I
Y
A
A
G
G
Y
D
G
Q
D
Q
L
N
S
V
E
R
Y
D
V
E
T
E
T
W
T
F
V
A
P
M
R
H
H
R
S
A
L
G
I
T
V
H
Q
G
K
I
Y
V
L
G
G
Y
D
G
H
T
F
L
D
S
V
E
C
Y
D
P
D
S
D
T
W
S
E
V
T
R
M
T
S
G
R
S
G
V
G
V
A
V
T
M
E
P
C
-----------
13
PsiBlast_PDB
74.38
96%
-94
- C2 -
-
5FZN
1
A:
[4-293]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
G
R
L
I
Y
T
A
G
G
Y
F
R
Q
S
L
S
Y
L
E
A
Y
N
P
S
N
G
S
W
L
R
L
A
D
L
Q
V
P
R
S
G
L
A
G
C
V
V
G
G
L
L
Y
A
V
G
G
R
N
N
S
P
D
G
N
T
D
S
S
A
L
D
C
Y
N
P
M
T
N
Q
W
S
P
C
A
S
M
S
V
P
R
N
R
I
G
V
G
V
I
D
G
H
I
Y
A
V
G
G
S
H
G
C
I
H
H
S
S
V
E
R
Y
E
P
E
R
D
E
W
H
L
V
A
P
M
L
T
R
R
I
G
V
G
V
A
V
L
N
R
L
L
Y
A
V
G
G
F
D
G
T
N
R
L
N
S
A
E
C
Y
Y
P
E
R
N
E
W
R
M
I
T
P
M
N
T
I
R
S
G
A
G
V
C
V
L
H
N
C
I
Y
A
A
G
G
Y
D
G
Q
D
Q
L
N
S
V
E
R
Y
D
V
E
T
E
T
W
T
F
V
A
P
M
R
H
H
R
S
A
L
G
I
T
V
H
Q
G
K
I
Y
V
L
G
G
Y
D
G
H
T
F
L
D
S
V
E
C
Y
D
P
D
S
D
T
W
S
E
V
T
R
M
T
S
G
R
S
G
V
G
V
A
V
T
M
E
P
C
-----------
5
PsiBlast_PDB
74.16
96%
-97
- C2 -
-
1X2J
-
A:
[16-305]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
G
R
L
I
Y
T
A
G
G
Y
F
R
Q
S
L
S
Y
L
E
A
Y
N
P
S
N
G
S
W
L
R
L
A
D
L
Q
V
P
R
S
G
L
A
G
C
V
V
G
G
L
L
Y
A
V
G
G
R
N
N
S
P
D
G
N
T
D
S
S
A
L
D
C
Y
N
P
M
T
N
Q
W
S
P
C
A
S
M
S
V
P
R
N
R
I
G
V
G
V
I
D
G
H
I
Y
A
V
G
G
S
H
G
C
I
H
H
S
S
V
E
R
Y
E
P
E
R
D
E
W
H
L
V
A
P
M
L
T
R
R
I
G
V
G
V
A
V
L
N
R
L
L
Y
A
V
G
G
F
D
G
T
N
R
L
N
S
A
E
C
Y
Y
P
E
R
N
E
W
R
M
I
T
P
M
N
T
I
R
S
G
A
G
V
C
V
L
H
N
C
I
Y
A
A
G
G
Y
D
G
Q
D
Q
L
N
S
V
E
R
Y
D
V
E
T
E
T
W
T
F
V
A
P
M
R
H
H
R
S
A
L
G
I
T
V
H
Q
G
K
I
Y
V
L
G
G
Y
D
G
H
T
F
L
D
S
V
E
C
Y
D
P
D
S
D
T
W
S
E
V
T
R
M
T
S
G
R
S
G
V
G
V
A
V
T
M
E
P
C
-----------
6
PsiBlast_PDB
74.02
96%
-99
- C2 -
-
1X2R
-
A:
[16-305]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
G
R
L
I
Y
T
A
G
G
Y
F
R
Q
S
L
S
Y
L
E
A
Y
N
P
S
N
G
S
W
L
R
L
A
D
L
Q
V
P
R
S
G
L
A
G
C
V
V
G
G
L
L
Y
A
V
G
G
R
N
N
S
P
D
G
N
T
D
S
S
A
L
D
C
Y
N
P
M
T
N
Q
W
S
P
C
A
S
M
S
V
P
R
N
R
I
G
V
G
V
I
D
G
H
I
Y
A
V
G
G
S
H
G
C
I
H
H
S
S
V
E
R
Y
E
P
E
R
D
E
W
H
L
V
A
P
M
L
T
R
R
I
G
V
G
V
A
V
L
N
R
L
L
Y
A
V
G
G
F
D
G
T
N
R
L
N
S
A
E
C
Y
Y
P
E
R
N
E
W
R
M
I
T
P
M
N
T
I
R
S
G
A
G
V
C
V
L
H
N
C
I
Y
A
A
G
G
Y
D
G
Q
D
Q
L
N
S
V
E
R
Y
D
V
E
T
E
T
W
T
F
V
A
P
M
R
H
H
R
S
A
L
G
I
T
V
H
Q
G
K
I
Y
V
L
G
G
Y
D
G
H
T
F
L
D
S
V
E
C
Y
D
P
D
S
D
T
W
S
E
V
T
R
M
T
S
G
R
S
G
V
G
V
A
V
T
M
E
P
C
-----------
2
PsiBlast_PDB
73.97
96%
-93
- C2 -
-
2DYH
-
KEAP1_MOUSE
A:
[17-312]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
G
R
L
I
Y
T
A
G
G
Y
F
R
Q
S
L
S
Y
L
E
A
Y
N
P
S
N
G
S
W
L
R
L
A
D
L
Q
V
P
R
S
G
L
A
G
C
V
V
G
G
L
L
Y
A
V
G
G
R
N
N
S
P
D
G
N
T
D
S
S
A
L
D
C
Y
N
P
M
T
N
Q
W
S
P
C
A
S
M
S
V
P
R
N
R
I
G
V
G
V
I
D
G
H
I
Y
A
V
G
G
S
H
G
C
I
H
H
S
S
V
E
R
Y
E
P
E
R
D
E
W
H
L
V
A
P
M
L
T
R
R
I
G
V
G
V
A
V
L
N
R
L
L
Y
A
V
G
G
F
D
G
T
N
R
L
N
S
A
E
C
Y
Y
P
E
R
N
E
W
R
M
I
T
P
M
N
T
I
R
S
G
A
G
V
C
V
L
H
N
C
I
Y
A
A
G
G
Y
D
G
Q
D
Q
L
N
S
V
E
R
Y
D
V
E
T
E
T
W
T
F
V
A
P
M
R
H
H
R
S
A
L
G
I
T
V
H
Q
G
K
I
Y
V
L
G
G
Y
D
G
H
T
F
L
D
S
V
E
C
Y
D
P
D
S
D
T
W
S
E
V
T
R
M
T
S
G
R
S
G
V
G
V
A
V
T
M
E
P
C
R
K
Q
I
D
Q
-----
14
PsiBlast_PDB
73.90
99%
-98
- C2 -
-
5F72
-
K:
[10-294]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
R
L
I
Y
T
A
G
G
Y
F
R
Q
S
L
S
Y
L
E
A
Y
N
P
S
D
G
T
W
L
D
L
A
D
L
Q
V
P
R
S
G
L
A
G
C
V
V
G
G
L
L
Y
A
V
G
G
R
N
N
S
P
D
G
N
T
D
S
S
A
L
D
C
Y
N
P
M
T
N
Q
W
S
P
C
A
P
M
S
V
P
R
N
R
I
G
V
G
V
I
D
G
H
I
Y
A
V
G
G
S
H
G
C
I
H
H
N
S
V
E
R
Y
E
P
E
R
D
E
W
H
L
V
A
P
M
L
T
R
R
I
G
V
G
V
A
V
L
N
R
L
L
Y
A
V
G
G
F
D
G
T
N
R
L
N
S
A
E
C
Y
Y
P
E
R
N
E
W
R
M
I
T
A
M
N
T
I
R
S
G
A
G
V
C
V
L
H
N
C
I
Y
A
A
G
G
Y
D
G
Q
D
Q
L
N
S
V
E
R
Y
D
V
E
T
E
T
W
T
F
V
A
P
M
K
H
R
R
S
A
L
G
I
T
V
H
Q
G
R
I
Y
V
L
G
G
Y
D
G
H
T
F
L
D
S
V
E
C
Y
D
P
D
T
D
T
W
S
E
V
T
R
M
T
S
G
R
S
G
V
G
V
A
V
T
---------------
7
PsiBlast_PDB
73.74
96%
-96
- C2 -
-
5FNQ
1
A:
[4-293]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
G
R
L
I
Y
T
A
G
G
Y
F
R
Q
S
L
S
Y
L
E
A
Y
N
P
S
N
G
S
W
L
R
L
A
D
L
Q
V
P
R
S
G
L
A
G
C
V
V
G
G
L
L
Y
A
V
G
G
R
N
N
S
P
D
G
N
T
D
S
S
A
L
D
C
Y
N
P
M
T
N
Q
W
S
P
C
A
S
M
S
V
P
R
N
R
I
G
V
G
V
I
D
G
H
I
Y
A
V
G
G
S
H
G
C
I
H
H
S
S
V
E
R
Y
E
P
E
R
D
E
W
H
L
V
A
P
M
L
T
R
R
I
G
V
G
V
A
V
L
N
R
L
L
Y
A
V
G
G
F
D
G
T
N
R
L
N
S
A
E
C
Y
Y
P
E
R
N
E
W
R
M
I
T
P
M
N
T
I
R
S
G
A
G
V
C
V
L
H
N
C
I
Y
A
A
G
G
Y
D
G
Q
D
Q
L
N
S
V
E
R
Y
D
V
E
T
E
T
W
T
F
V
A
P
M
R
H
H
R
S
A
L
G
I
T
V
H
Q
G
K
I
Y
V
L
G
G
Y
D
G
H
T
F
L
D
S
V
E
C
Y
D
P
D
S
D
T
W
S
E
V
T
R
M
T
S
G
R
S
G
V
G
V
A
V
T
M
E
P
C
-----------
8
PsiBlast_PDB
73.45
96%
-95
- C2 -
-
5FNR
1
A:
[5-293]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
R
L
I
Y
T
A
G
G
Y
F
R
Q
S
L
S
Y
L
E
A
Y
N
P
S
N
G
S
W
L
R
L
A
D
L
Q
V
P
R
S
G
L
A
G
C
V
V
G
G
L
L
Y
A
V
G
G
R
N
N
S
P
D
G
N
T
D
S
S
A
L
D
C
Y
N
P
M
T
N
Q
W
S
P
C
A
S
M
S
V
P
R
N
R
I
G
V
G
V
I
D
G
H
I
Y
A
V
G
G
S
H
G
C
I
H
H
S
S
V
E
R
Y
E
P
E
R
D
E
W
H
L
V
A
P
M
L
T
R
R
I
G
V
G
V
A
V
L
N
R
L
L
Y
A
V
G
G
F
D
G
T
N
R
L
N
S
A
E
C
Y
Y
P
E
R
N
E
W
R
M
I
T
P
M
N
T
I
R
S
G
A
G
V
C
V
L
H
N
C
I
Y
A
A
G
G
Y
D
G
Q
D
Q
L
N
S
V
E
R
Y
D
V
E
T
E
T
W
T
F
V
A
P
M
R
H
H
R
S
A
L
G
I
T
V
H
Q
G
K
I
Y
V
L
G
G
Y
D
G
H
T
F
L
D
S
V
E
C
Y
D
P
D
S
D
T
W
S
E
V
T
R
M
T
S
G
R
S
G
V
G
V
A
V
T
M
E
P
C
-----------
19
PsiBlast_PDB
73.39
96%
-96
- C2 -
-
2FLU
-
X:
[24-308]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
R
L
I
Y
T
A
G
G
Y
F
R
Q
S
L
S
Y
L
E
A
Y
N
P
S
D
G
T
W
L
R
L
A
D
L
Q
V
P
R
S
G
L
A
G
C
V
V
G
G
L
L
Y
A
V
G
G
R
N
N
S
P
D
G
N
T
D
S
S
A
L
D
C
Y
N
P
M
T
N
Q
W
S
P
C
A
P
M
S
V
P
R
N
R
I
G
V
G
V
I
D
G
H
I
Y
A
V
G
G
S
H
G
C
I
H
H
N
S
V
E
R
Y
E
P
E
R
D
E
W
H
L
V
A
P
M
L
T
R
R
I
G
V
G
V
A
V
L
N
R
L
L
Y
A
V
G
G
F
D
G
T
N
R
L
N
S
A
E
C
Y
Y
P
E
R
N
E
W
R
M
I
T
A
M
N
T
I
R
S
G
A
G
V
C
V
L
H
N
C
I
Y
A
A
G
G
Y
D
G
Q
D
Q
L
N
S
V
E
R
Y
D
V
E
T
E
T
W
T
F
V
A
P
M
K
H
R
R
S
A
L
G
I
T
V
H
Q
G
R
I
Y
V
L
G
G
Y
D
G
H
T
F
L
D
S
V
E
C
Y
D
P
D
T
D
T
W
S
E
V
T
R
M
T
S
G
R
S
G
V
G
V
A
V
T
---------------
11
PsiBlast_PDB
73.39
96%
-96
- C2 -
-
5FNU
1
A:
[6-293]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
I
Y
T
A
G
G
Y
F
R
Q
S
L
S
Y
L
E
A
Y
N
P
S
N
G
S
W
L
R
L
A
D
L
Q
V
P
R
S
G
L
A
G
C
V
V
G
G
L
L
Y
A
V
G
G
R
N
N
S
P
D
G
N
T
D
S
S
A
L
D
C
Y
N
P
M
T
N
Q
W
S
P
C
A
S
M
S
V
P
R
N
R
I
G
V
G
V
I
D
G
H
I
Y
A
V
G
G
S
H
G
C
I
H
H
S
S
V
E
R
Y
E
P
E
R
D
E
W
H
L
V
A
P
M
L
T
R
R
I
G
V
G
V
A
V
L
N
R
L
L
Y
A
V
G
G
F
D
G
T
N
R
L
N
S
A
E
C
Y
Y
P
E
R
N
E
W
R
M
I
T
P
M
N
T
I
R
S
G
A
G
V
C
V
L
H
N
C
I
Y
A
A
G
G
Y
D
G
Q
D
Q
L
N
S
V
E
R
Y
D
V
E
T
E
T
W
T
F
V
A
P
M
R
H
H
R
S
A
L
G
I
T
V
H
Q
G
K
I
Y
V
L
G
G
Y
D
G
H
T
F
L
D
S
V
E
C
Y
D
P
D
S
D
T
W
S
E
V
T
R
M
T
S
G
R
S
G
V
G
V
A
V
T
M
E
P
C
-----------
4
PsiBlast_PDB
73.22
96%
-95
- C2 -
-
3ADE
-
A:
[18-306]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
R
L
I
Y
T
A
G
G
Y
F
R
Q
S
L
S
Y
L
E
A
Y
N
P
S
N
G
S
W
L
R
L
A
D
L
Q
V
P
R
S
G
L
A
G
C
V
V
G
G
L
L
Y
A
V
G
G
R
N
N
S
P
D
G
N
T
D
S
S
A
L
D
C
Y
N
P
M
T
N
Q
W
S
P
C
A
S
M
S
V
P
R
N
R
I
G
V
G
V
I
D
G
H
I
Y
A
V
G
G
S
H
G
C
I
H
H
S
S
V
E
R
Y
E
P
E
R
D
E
W
H
L
V
A
P
M
L
T
R
R
I
G
V
G
V
A
V
L
N
R
L
L
Y
A
V
G
G
F
D
G
T
N
R
L
N
S
A
E
C
Y
Y
P
E
R
N
E
W
R
M
I
T
P
M
N
T
I
R
S
G
A
G
V
C
V
L
H
N
C
I
Y
A
A
G
G
Y
D
G
Q
D
Q
L
N
S
V
E
R
Y
D
V
E
T
E
T
W
T
F
V
A
P
M
R
H
H
R
S
A
L
G
I
T
V
H
Q
G
K
I
Y
V
L
G
G
Y
D
G
H
T
F
L
D
S
V
E
C
Y
D
P
D
S
D
T
W
S
E
V
T
R
M
T
S
G
R
S
G
V
G
V
A
V
T
M
E
P
C
-----------
15
PsiBlast_PDB
73.02
100%
-98
- C2 -
-
4IFL
-
X:
[7-291]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
R
L
I
Y
T
A
G
G
Y
F
R
Q
S
L
S
Y
L
E
A
Y
N
P
S
D
G
T
W
L
R
L
A
D
L
Q
V
P
R
S
G
L
A
G
C
V
V
G
G
L
L
Y
A
V
G
G
R
N
N
S
P
D
G
N
T
D
S
S
A
L
D
C
Y
N
P
M
T
N
Q
W
S
P
C
A
P
M
S
V
P
R
N
R
I
G
V
G
V
I
D
G
H
I
Y
A
V
G
G
S
H
G
C
I
H
H
N
S
V
E
R
Y
E
P
E
R
D
E
W
H
L
V
A
P
M
L
T
R
R
I
G
V
G
V
A
V
L
N
R
L
L
Y
A
V
G
G
F
D
G
T
N
R
L
N
S
A
E
C
Y
Y
P
E
R
N
E
W
R
M
I
T
A
M
N
T
I
R
S
G
A
G
V
C
V
L
H
N
C
I
Y
A
A
G
G
Y
D
G
Q
D
Q
L
N
S
V
E
R
Y
D
V
E
T
E
T
W
T
F
V
A
P
M
K
H
R
R
S
A
L
G
I
T
V
H
Q
G
R
I
Y
V
L
G
G
Y
D
G
H
T
F
L
D
S
V
E
C
Y
D
P
D
T
D
T
W
S
E
V
T
R
M
T
S
G
R
S
G
V
G
V
A
V
T
---------------
21
Fugue
72.18
100%
-94
- C- -
-
1U6D
-
KEAP1_HUMAN
X:
[322-609]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
K
V
G
R
L
I
Y
T
A
G
G
Y
F
R
Q
S
L
S
Y
L
E
A
Y
N
P
S
D
G
T
W
L
R
L
A
D
L
Q
V
P
R
S
G
L
A
G
C
V
V
G
G
L
L
Y
A
V
G
G
R
N
N
S
P
D
G
N
T
D
S
S
A
L
D
C
Y
N
P
M
T
N
Q
W
S
P
C
A
P
M
S
V
P
R
N
R
I
G
V
G
V
I
D
G
H
I
Y
A
V
G
G
S
H
G
C
I
H
H
N
S
V
E
R
Y
E
P
E
R
D
E
W
H
L
V
A
P
M
L
T
R
R
I
G
V
G
V
A
V
L
N
R
L
L
Y
A
V
G
G
F
D
G
T
N
R
L
N
S
A
E
C
Y
Y
P
E
R
N
E
W
R
M
I
T
A
M
N
T
I
R
S
G
A
G
V
C
V
L
H
N
C
I
Y
A
A
G
G
Y
D
G
Q
D
Q
L
N
S
V
E
R
Y
D
V
E
T
E
T
W
T
F
V
A
P
M
K
H
R
R
S
A
L
G
I
T
V
H
Q
G
R
I
Y
V
L
G
G
Y
D
G
H
T
F
L
D
S
V
E
C
Y
D
P
D
T
D
T
W
S
E
V
T
R
M
T
S
G
R
S
G
V
G
V
A
V
T
---------------
1
PsiBlast_PDB
72.08
94%
-102
- C2 -
-
5CGJ
1
KEAP1_MOUSE
A:
[36-325]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
G
R
L
I
Y
T
A
G
G
Y
F
R
Q
S
L
S
Y
L
E
A
Y
N
P
S
N
G
S
W
L
R
L
A
D
L
Q
V
P
R
S
G
L
A
G
C
V
V
G
G
L
L
Y
A
V
G
G
R
N
N
S
P
D
G
N
T
D
S
S
A
L
D
C
Y
N
P
M
T
N
Q
W
S
P
C
A
S
M
S
V
P
R
N
R
I
G
V
G
V
I
D
G
H
I
Y
A
V
G
G
S
H
G
C
I
H
H
S
S
V
E
R
Y
E
P
E
R
D
E
W
H
L
V
A
P
M
L
T
R
R
I
G
V
G
V
A
V
L
N
R
L
L
Y
A
V
G
G
F
D
G
T
N
R
L
N
S
A
E
C
Y
Y
P
E
R
N
E
W
R
M
I
T
P
M
N
T
I
R
S
G
A
G
V
C
V
L
H
N
C
I
Y
A
A
G
G
Y
D
G
Q
D
Q
L
N
S
V
E
R
Y
D
V
E
T
E
T
W
T
F
V
A
P
M
R
H
H
R
S
A
L
G
I
T
V
H
Q
G
K
I
Y
V
L
G
G
Y
D
G
H
T
F
L
D
S
V
E
C
Y
D
P
D
S
D
T
W
S
E
V
T
R
M
T
S
G
R
S
G
V
G
V
A
V
T
M
E
P
C
-----------
16
PsiBlast_PDB
72.07
100%
-99
- C2 -
-
4IFN
1
X:
[7-291]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
R
L
I
Y
T
A
G
G
Y
F
R
Q
S
L
S
Y
L
E
A
Y
N
P
S
D
G
T
W
L
R
L
A
D
L
Q
V
P
R
S
G
L
A
G
C
V
V
G
G
L
L
Y
A
V
G
G
R
N
N
S
P
D
G
N
T
D
S
S
A
L
D
C
Y
N
P
M
T
N
Q
W
S
P
C
A
P
M
S
V
P
R
N
R
I
G
V
G
V
I
D
G
H
I
Y
A
V
G
G
S
H
G
C
I
H
H
N
S
V
E
R
Y
E
P
E
R
D
E
W
H
L
V
A
P
M
L
T
R
R
I
G
V
G
V
A
V
L
N
R
L
L
Y
A
V
G
G
F
D
G
T
N
R
L
N
S
A
E
C
Y
Y
P
E
R
N
E
W
R
M
I
T
A
M
N
T
I
R
S
G
A
G
V
C
V
L
H
N
C
I
Y
A
A
G
G
Y
D
G
Q
D
Q
L
N
S
V
E
R
Y
D
V
E
T
E
T
W
T
F
V
A
P
M
K
H
R
R
S
A
L
G
I
T
V
H
Q
G
R
I
Y
V
L
G
G
Y
D
G
H
T
F
L
D
S
V
E
C
Y
D
P
D
T
D
T
W
S
E
V
T
R
M
T
S
G
R
S
G
V
G
V
A
V
T
---------------
20
PsiBlast_PDB
71.44
100%
-95
- C2 -
-
3VNG
1
A:
[22-309]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
K
V
G
R
L
I
Y
T
A
G
G
Y
F
R
Q
S
L
S
Y
L
E
A
Y
N
P
S
D
G
T
W
L
R
L
A
D
L
Q
V
P
R
S
G
L
A
G
C
V
V
G
G
L
L
Y
A
V
G
G
R
N
N
S
P
D
G
N
T
D
S
S
A
L
D
C
Y
N
P
M
T
N
Q
W
S
P
C
A
P
M
S
V
P
R
N
R
I
G
V
G
V
I
D
G
H
I
Y
A
V
G
G
S
H
G
C
I
H
H
N
S
V
E
R
Y
E
P
E
R
D
E
W
H
L
V
A
P
M
L
T
R
R
I
G
V
G
V
A
V
L
N
R
L
L
Y
A
V
G
G
F
D
G
T
N
R
L
N
S
A
E
C
Y
Y
P
E
R
N
E
W
R
M
I
T
A
M
N
T
I
R
S
G
A
G
V
C
V
L
H
N
C
I
Y
A
A
G
G
Y
D
G
Q
D
Q
L
N
S
V
E
R
Y
D
V
E
T
E
T
W
T
F
V
A
P
M
K
H
R
R
S
A
L
G
I
T
V
H
Q
G
R
I
Y
V
L
G
G
Y
D
G
H
T
F
L
D
S
V
E
C
Y
D
P
D
T
D
T
W
S
E
V
T
R
M
T
S
G
R
S
G
V
G
V
A
V
T
---------------
18
PsiBlast_PDB
71.23
96%
-94
- C- -
-
1U6D
-
KEAP1_HUMAN
X:
[322-609]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
K
V
G
R
L
I
Y
T
A
G
G
Y
F
R
Q
S
L
S
Y
L
E
A
Y
N
P
S
D
G
T
W
L
R
L
A
D
L
Q
V
P
R
S
G
L
A
G
C
V
V
G
G
L
L
Y
A
V
G
G
R
N
N
S
P
D
G
N
T
D
S
S
A
L
D
C
Y
N
P
M
T
N
Q
W
S
P
C
A
P
M
S
V
P
R
N
R
I
G
V
G
V
I
D
G
H
I
Y
A
V
G
G
S
H
G
C
I
H
H
N
S
V
E
R
Y
E
P
E
R
D
E
W
H
L
V
A
P
M
L
T
R
R
I
G
V
G
V
A
V
L
N
R
L
L
Y
A
V
G
G
F
D
G
T
N
R
L
N
S
A
E
C
Y
Y
P
E
R
N
E
W
R
M
I
T
A
M
N
T
I
R
S
G
A
G
V
C
V
L
H
N
C
I
Y
A
A
G
G
Y
D
G
Q
D
Q
L
N
S
V
E
R
Y
D
V
E
T
E
T
W
T
F
V
A
P
M
K
H
R
R
S
A
L
G
I
T
V
H
Q
G
R
I
Y
V
L
G
G
Y
D
G
H
T
F
L
D
S
V
E
C
Y
D
P
D
T
D
T
W
S
E
V
T
R
M
T
S
G
R
S
G
V
G
V
A
V
T
---------------