@TOME V2.3
(Mar 2018)

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Alignment:

3D Common Core:

Structural Clustering:

Modeller Result :

Complexes Modeling
Templates Information:
Sequence & Result Tab:

Values color: [ Good | Correct | Middling | Bad ]Sequence color : MutatedHelixStrandConserved

Query sequence : NCKP1_HUMAN: (2018-07-13 )
MSRSVLQPSQQKLAEKLTILNDRGVGMLTRLYNIKKACGDPKAKPSYLIDKNLESAVKFIVRKFPAVETRNNNQQLAQLQKEKSEILKNLALYYFTFVDVMEFKDHVCELLNTIDVCQVFFDITVNFDLTKNYLDLIITYTTLMILLSRIEERKAIIGLYNYAHEMTHGASDREYPRLGQMIVDYENPLKKMMEEFVPHSKSLSDALISLQMVYPRRNLSADQWRNAQLLSLISAPSTMLNPAQSDTMPCEYLSLDAMEKWIIFGFILCHGILNTDATALNLWKLALQSSSCLSLFRDEVFHIHKAAEDLFVNIRGYNKRINDIRECKEAAVSHAGSMHRERRKFLRSALKELATVLSDQPGLLGPKALFVFMALSFARDEIIWLLRHADNMPKKSADDFIDKHIAELIFYMEELRAHVRKYGPVMQRYYVQYLSGFDAVVLNELVQNLSVCPEDESIIMSSFVNTMTSLSVKQVEDGEVFDFRGMRLDWFRLQAYTSVSKASLGLADHRELGKMMNTIIFHTKMVDSLVEMLVETSDLSIFCFYSRAFEKMFQQCLELPSQSRYSIAFPLLCTHFMSCTHELCPEERHHIGDRSLSLCNMFLDEMAKQARNLITDICTEQCTLSDQLLPKHCAKTISQAVNKKSKKQTGKKGEPEREKPGVESMRKNRLVVTNLDKLHTALSELCFSINYVPNMVVWEHTFTPREYLTSHLEIRFTKSIVGMTMYNQATQEIAKPSELLTSVRAYMTVLQSIENYVQIDITRVFNNVLLQQTQHLDSHGEPTITSLYTNWYLETLLRQVSNGHIAYFPAMKAFVNLPTENELTFNAEEYSDISEMRSLSELLGPYGMKFLSESLMWHISSQVAELKKLVVENVDVLTQMRTSFDKPDQMAALFKRLSSVDSVLKRMTIIGVILSFRSLAQEALRDVLSYHIPFLVSSIEDFKDHIPRETDMKVAMNVYELSSAAGLPCEIDPALVVALSSQKSENISPEEEYKIACLLMVFVAVSLPTLASNVMSQYSPAIEGHCNNIHCLAKAINQIAAALFTIHKGSIEDRLKEFLALASSSLLKIGQETDKTTTRNRESVYLLLDMIVQESPFLTMDLLESCFPYVLLRNAYHAVYKQSVTSSA

Atome Classification :

(20 SA) ---.........10..---......20...-----.....30...-.....40........50....--....60........70-........80----........90........100.......110.......120.......130.......140....----...150.......160.----.....---.170.......180.......190.......200.-......210.......220---------........230.......240--------........250....--------...260....--...270.........280.......--290.......300---....-...310..-....--.320.......330......--.340.......350.......360...---....370...--....380.......390-........400.......410---.......420....------...430-----...-.....440.......450.......460.......470-------....-----------...480---..-.-....490.......500.......----510.........520-----..--..-.....530......--.-----540..----.....550-----.....--------...560.......570-----.........580-----------.------........590.......600------....---.....610..--.....620.......630...----------...-.640.......----650.....-..660.......670..-----------.....680.......690.....-----..700.----------.--.....710.......720------....-....-----.730.......--740.......750....-...760...-....770.......780....-...790.--...-------...800......-.-----------810......----.-------------820----..--.-...---------...830---.......840-........850.------------------......860..---.....870.....-..---880........890......------.------900---------.-........910.......920....----...930.......-----940.......-950.......960.......970.......980.......990.......1000......1010......1020----......1030......1040---......1050......1060......1070.....----.1080.......--.1090......1100......1110......1120.....-----------
(Atome) (Ident) (Tito) (Num) (QMean) (Ligand) (Uniprot) ---MSRSVLQPSQQKL---AEKLTILNDRG-----VGMLTRLYNI-KKACGDPKAKPSYLIDKNLES--AVKFIVRKFPAVETRN-NNQQLAQLQK----EKSEILKNLALYYFTFVDVMEFKDHVCELLNTIDVCQVFFDITVNFDLTKNYLDLIITYTTLMIL----LSRIEERKAIIGLYNYA----HEMTH---GASDREYPRLGQMIVDYENPLKKMMEEFVPHSKSL-SDALISLQMVYPRRNLSA----------DQWRNAQLLSLISAPSTMLN---------PAQSDTMPCEYLSLD--------AMEKWIIFGF--ILCH--GILNTDATALNLWKLALQS--SSCLSLFRDEVFH---IHKA-AEDLFVNI-RGYN--KRINDIRECKEAAVSHAGSM--HRERRKFLRSALKELATVLSDQPGLLG---PKALFVFMAL--SFARDEIIWLLRHADN--MPKKSADDFIDKHIAELIFYM---EELRAHVRKYGPVM------QRYYV------QYL-SGFDAVVLNELVQNLSVCPEDESIIMSSFVNTMTSLSV-------KQVE-----------DGEVFD---FR-G-MRLDWFRLQAYTSVSKASLGLADH----R--ELGKMMNTII-------FH--TK-MVDSLVEMLVETSD--L-----SIFCF----YSRAFEK------MFQQC--------LELPSQSRYSIAFP-------LLCTHFMSCT-------------H------ELCPEERHHIGDRSLSLCN--------MFLD---EMAKQARNLI--TDICTEQCTLSDQLLPKHCAK----------TIS-QAVNKKSKKQT----GKKGEPER-EKPGVESMRKNRLVVTN-----------LDKLHTALSELCFSINYVPNMVV-----WEHTFT----------P--REYLTSHLEIRFTKSI--------VGMT-MYNQ-----ATQEIAKPSEL--LTSVRAYMTVLQSIENY-VQIDITRVF-NNVLLQQTQHLDSHGEPTITS-LYTNWYL--ETL-------LRQVSNGHIAYF-P-----------AMKAFVNLP----T-------------E------NE--L-TFN---------AEEYSD---ISEMRSLSE--LLGPYGMKFLSE------------------SLMWHISSQVA---ELKKLVVENVDVL-TQ---M-RTSFDKPDQMAALFKRLS------S------V-----------D-SVLKRMTIIGVILSFRSLAQEALRD----VLSYHIPFLVSSI-----EDFKDHIPRE-TDMKVAMNVYELSSAAGLPCEIDPALVVALSSQKSENISPEEEYKIACLLMVFVAVSLPTLASNVMSQYSPAIE----GHCNNIHCLAKAINQIAAAL---FTIHKGSIEDRLKEFLALASSSLLKIGQETDKTTT----RN--RESVYLLL--DMIVQESPFLTMDLLESCFPYVLLRNAYHAVYKQSVTSSA-----------
14 Fugue 89.8099%-154 - C7 - - 3P8C NCKP1_HUMAN B:[7-1121] ---------QPSQQKL---AEKLTILNDRG-----VGMLTRLYNI-KKACGDPKAKPSYLIDKNLES--AVKFIVRKFP----AV-ENQQLAQLQK----EKSEILKNLALYYFTFVDVMEFKDHVCELLNTIDVCQVFFDITVNFDLTKNYLDLIITYTTLMIL----LSRIEERKAIIGLYNYA----HEMTH---GASDREYPRLGQMIVDYENPLKKMMEEFVPHSKSL-SDALISLQMVYPRRNLSA----------DQWRNAQLLSLISAPSTMLN---------PAQSDTMPCEYLSLD--------AMEKWIIFGF--ILCH--GILNTDATALNLWKLALQS--SSCLSLFRDEVFH---IHKA-AEDLFVNI-RGYN--KRINDIRECKEAAVSHAGSM--HRERRKFLRSALKELATVLSDQPGLLG---PKALFVFMAL--SFARDEIIWLLRHADN--MPKKSADDFIDKHIAELIFYM---EELRAHVRKYGPVM------QRYYV------QYL-SGFDAVVLNELVQNLSVCPEDESIIMSSFVNTMTSLSV-------KQVE-----------DGEVFD---FR-G-MRLDWFRLQAYTSVSKASLGLADH----R--ELGKMMNTII-------FH--TK-MVDSLVEMLVETSD--L-----SIFCF----YSRAFEK------MFQQC--------LELPSQSRYSIAFP-------LLCTHFMSCT-------------H------ELCPEERHHIGDRSLSLCN--------MFLD---EMAKQARNLI--TDICTEQCTLSDQLLPKHCAK----------TIS-QA------------------VNK-EKPGVESMRKNRLVVTN-----------LDKLHTALSELCFSINYVPNMVV-----WEHTFT----------P--REYLTSHLEIRFTKSI--------VGMT-MYNQ-----ATQEIAKPSEL--LTSVRAYMTVLQSIENY-VQIDITRVF-NNVLLQQTQHLDSHGEPTITS-LYTNWYL--ETL-------LRQVSNGHIAYF-P-----------AMKAFVNLP----T-------------E------NE--L-TFN---------AEEYSD---ISEMRSLSE--LLGPYGMKFLSE------------------SLMWHISSQVA---ELKKLVVENVDVL-TQ---M-RTSFDKPDQMAALFKRLS------S------V-----------D-SVLKRMTIIGVILSFRSLAQEALRD----VLSYHIPFLVSSI-----EDFKDHDMKV------AMNVYELSSAAGLPCEIDPALVVALSS------SPEEEYKIACLLMVFVAVSLPTLASNVMSQYSPAIE----GHCNNIHCLAKAINQIAAAL---FTIHKGSIEDRLKEFLALASSSLLKIGQETDKTTT----RN--RESVYLLL--DMIVQESPFLTMDLLESCFPYVLLRNAYHAVYK------------------
2 PsiBlast_PDB 89.71100%-155 - C7 - - 4N78 NCKP1_HUMAN B:[7-1121] ---------QPSQQKL---AEKLTILNDRG-----VGMLTRLYNI-KKACGDPKAKPSYLIDKNLES--AVKFIVRKFPAV---------LAQLQK----EKSEILKNLALYYFTFVDVMEFKDHVCELLNTIDVCQVFFDITVNFDLTKNYLDLIITYTTLMIL----LSRIEERKAIIGLYNYA----HEMTH---GASDREYPRLGQMIVDYENPLKKMMEEFVPHSKSL-SDALISLQMVYPRRNLSA----------DQWRNAQLLSLISAPSTMLN---------PAQSDTMPCEYLSLD--------AMEKWIIFGF--ILCH--GILNTDATALNLWKLALQS--SSCLSLFRDEVFH---IHKA-AEDLFVNI-RGYN--KRINDIRECKEAAVSHAGSM--HRERRKFLRSALKELATVLSDQPGLLG---PKALFVFMAL--SFARDEIIWLLRHADN--MPKKSADDFIDKHIAELIFYM---EELRAHVRKYGPVM------QRYYV------QYL-SGFDAVVLNELVQNLSVCPEDESIIMSSFVNTMTSLSV-------KQVE-----------DGEVFD---FR-G-MRLDWFRLQAYTSVSKASLGLADH----R--ELGKMMNTII-------FH--TK-MVDSLVEMLVETSD--L-----SIFCF----YSRAFEK------MFQQC--------LELPSQSRYSIAFP-------LLCTHFMSCT-------------H------ELCPEERHHIGDRSLSLCN--------MFLD---EMAKQARNLI--TDICTEQCTLSDQLLPKHCAK----------TIS-QAVNK-------------------EKPGVESMRKNRLVVTN-----------LDKLHTALSELCFSINYVPNMVV-----WEHTFT----------P--REYLTSHLEIRFTKSI--------VGMT-MYNQ-----ATQEIAKPSEL--LTSVRAYMTVLQSIENY-VQIDITRVF-NNVLLQQTQHLDSHGEPTITS-LYTNWYL--ETL-------LRQVSNGHIAYF-P-----------AMKAFVNLP----T-------------E------NE--L-TFN---------AEEYSD---ISEMRSLSE--LLGPYGMKFLSE------------------SLMWHISSQVA---ELKKLVVENVDVL-TQ---M-RTSFDKPDQMAALFKRLS------S------V-----------D-SVLKRMTIIGVILSFRSLAQEALRD----VLSYHIPFLVSSI-----EDFKDHIP---TDMKVAMNVYELSSAAGLPCEIDPALVVALSS------SPEEEYKIACLLMVFVAVSLPTLASNVMSQYSPAIE----GHCNNIHCLAKAINQIAAAL---FTIHKGSIEDRLKEFLALASSSLLKIGQETDKTTT----RN--RESVYLLL--DMIVQESPFLTMDLLESCFPYVLLRNAYHAVYK------------------
4 HHSearch 89.69100%-154 - C7 - - 3P8C NCKP1_HUMAN B:[7-1121] ---------QPSQQKL---AEKLTILNDRG-----VGMLTRLYNI-KKACGDPKAKPSYLIDKNLES--AVKFIVRKFPAVE-----NQQLAQLQK----EKSEILKNLALYYFTFVDVMEFKDHVCELLNTIDVCQVFFDITVNFDLTKNYLDLIITYTTLMIL----LSRIEERKAIIGLYNYA----HEMTH---GASDREYPRLGQMIVDYENPLKKMMEEFVPHSKSL-SDALISLQMVYPRRNLSA----------DQWRNAQLLSLISAPSTMLN---------PAQSDTMPCEYLSLD--------AMEKWIIFGF--ILCH--GILNTDATALNLWKLALQS--SSCLSLFRDEVFH---IHKA-AEDLFVNI-RGYN--KRINDIRECKEAAVSHAGSM--HRERRKFLRSALKELATVLSDQPGLLG---PKALFVFMAL--SFARDEIIWLLRHADN--MPKKSADDFIDKHIAELIFYM---EELRAHVRKYGPVM------QRYYV------QYL-SGFDAVVLNELVQNLSVCPEDESIIMSSFVNTMTSLSV-------KQVE-----------DGEVFD---FR-G-MRLDWFRLQAYTSVSKASLGLADH----R--ELGKMMNTII-------FH--TK-MVDSLVEMLVETSD--L-----SIFCF----YSRAFEK------MFQQC--------LELPSQSRYSIAFP-------LLCTHFMSCT-------------H------ELCPEERHHIGDRSLSLCN--------MFLD---EMAKQARNLI--TDICTEQCTLSDQLLPKHCAK----------TIS-QAVNK-------------------EKPGVESMRKNRLVVTN-----------LDKLHTALSELCFSINYVPNMVV-----WEHTFT----------P--REYLTSHLEIRFTKSI--------VGMT-MYNQ-----ATQEIAKPSEL--LTSVRAYMTVLQSIENY-VQIDITRVF-NNVLLQQTQHLDSHGEPTITS-LYTNWYL--ETL-------LRQVSNGHIAYF-P-----------AMKAFVNLP----T-------------E------NE--L-TFN---------AEEYSD---ISEMRSLSE--LLGPYGMKFLSE------------------SLMWHISSQVA---ELKKLVVENVDVL-TQ---M-RTSFDKPDQMAALFKRLS------S------V-----------D-SVLKRMTIIGVILSFRSLAQEALRD----VLSYHIPFLVSSI-----EDFKDH------DMKVAMNVYELSSAAGLPCEIDPALVVALSS------SPEEEYKIACLLMVFVAVSLPTLASNVMSQYSPAIE----GHCNNIHCLAKAINQIAAAL---FTIHKGSIEDRLKEFLALASSSLLKIGQETDKTTT----RN--RESVYLLL--DMIVQESPFLTMDLLESCFPYVLLRNAYHAVYK------------------
1 PsiBlast_PDB 89.69100%-154 - C7 - - 3P8C NCKP1_HUMAN B:[7-1121] ---------QPSQQKL---AEKLTILNDRG-----VGMLTRLYNI-KKACGDPKAKPSYLIDKNLES--AVKFIVRKFPAVE-----NQQLAQLQK----EKSEILKNLALYYFTFVDVMEFKDHVCELLNTIDVCQVFFDITVNFDLTKNYLDLIITYTTLMIL----LSRIEERKAIIGLYNYA----HEMTH---GASDREYPRLGQMIVDYENPLKKMMEEFVPHSKSL-SDALISLQMVYPRRNLSA----------DQWRNAQLLSLISAPSTMLN---------PAQSDTMPCEYLSLD--------AMEKWIIFGF--ILCH--GILNTDATALNLWKLALQS--SSCLSLFRDEVFH---IHKA-AEDLFVNI-RGYN--KRINDIRECKEAAVSHAGSM--HRERRKFLRSALKELATVLSDQPGLLG---PKALFVFMAL--SFARDEIIWLLRHADN--MPKKSADDFIDKHIAELIFYM---EELRAHVRKYGPVM------QRYYV------QYL-SGFDAVVLNELVQNLSVCPEDESIIMSSFVNTMTSLSV-------KQVE-----------DGEVFD---FR-G-MRLDWFRLQAYTSVSKASLGLADH----R--ELGKMMNTII-------FH--TK-MVDSLVEMLVETSD--L-----SIFCF----YSRAFEK------MFQQC--------LELPSQSRYSIAFP-------LLCTHFMSCT-------------H------ELCPEERHHIGDRSLSLCN--------MFLD---EMAKQARNLI--TDICTEQCTLSDQLLPKHCAK----------TIS-QAVNK-------------------EKPGVESMRKNRLVVTN-----------LDKLHTALSELCFSINYVPNMVV-----WEHTFT----------P--REYLTSHLEIRFTKSI--------VGMT-MYNQ-----ATQEIAKPSEL--LTSVRAYMTVLQSIENY-VQIDITRVF-NNVLLQQTQHLDSHGEPTITS-LYTNWYL--ETL-------LRQVSNGHIAYF-P-----------AMKAFVNLP----T-------------E------NE--L-TFN---------AEEYSD---ISEMRSLSE--LLGPYGMKFLSE------------------SLMWHISSQVA---ELKKLVVENVDVL-TQ---M-RTSFDKPDQMAALFKRLS------S------V-----------D-SVLKRMTIIGVILSFRSLAQEALRD----VLSYHIPFLVSSI-----EDFKDH------DMKVAMNVYELSSAAGLPCEIDPALVVALSS------SPEEEYKIACLLMVFVAVSLPTLASNVMSQYSPAIE----GHCNNIHCLAKAINQIAAAL---FTIHKGSIEDRLKEFLALASSSLLKIGQETDKTTT----RN--RESVYLLL--DMIVQESPFLTMDLLESCFPYVLLRNAYHAVYK------------------
17 Fugue 39.5319%-130 * C7 * - 2P5T - PEZA_STRPN A:[67-158] -------LNPVEDYEL---TLKIEIVKERG-----ANLLSRLYRY-QDSQGISIDDESNPWILMSDD--LSDLIHTNIYLVET----FDEIERYSG----YLDGIERMLEISEKRMVA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18 Fugue 38.4617% -9 * C6 * - 5IFE - SF3B1_HUMAN C:[463-1304] ----NLPFLKPDDIQY---FDKLLVDVDESEEQKERKIMKLLLKI-KNGTPPMRKAALRQITDKAREFGAGPLFNQILPLLMSPTLEDQERHLLVK----VIDRILYKLD------------------------------------DLVRPYVHKILVVIEPLLIDEDYYARVEGREIISNLAKAA----G----------------LATMISTMRPDIDNM-DEYVRNTTAR-AFAVVASAL----------------------GIPSLLPFLKAVCKSKK---------SWQARHTGIKIVQQI--------AILM--------------------------------G--CAILPHLRSLVEI---IEHG-LVD------------EQQKVRTISALAIAALAEAA--TPYGIESFDSVLKPLWKGIRQHRG-------KGLAAFLKA--IGYLIPL-----------MDAEYANYYTREVMLILIREF---QSPDEEMKKI--VL------K--VV------KQC-CGTDGVEANYIKTE----------ILPPFFKH--------------------------------FW---QH-R-MALD---RRNYRQLVDTTVELANK----V--GAAEIISRIV-------DD--LKDEAEQYRKMVMETIE--K-----IMGNLGAADIDHKLEE------QLIDG--------ILYAFQEQTT-EDS-------VMLNGFGTVV-------------N------ALGKRVKPYLPQICGTVLW--------RLNNKSAKVRQQAADLI--SRTAVVMKTCQEEKLMGHLGV----------VLY-EYLG-------------------------------------------------EEYPEVLGSILGALKAIVN-VI-----GMHKMT----------PPIKDLLPRLTPILKNRHE--------KVQE-NCID-----LVGRIADRGAE--YVSAREWMRICFELLEL-LKAHKKAIR-RATVNTFGYIAKAIGPHDVLA-TLQNRVC--TTV-------AIAIVAETCSPF-T-----------VLPALMN--------------------E------YR--V-PEL---------NVQNGV---LKSLSFLFE--YIGEMGKDY------------------------------IY---AVTPLLEDAL---------M-DRDLVHRQTASAVVQHMS------L------G-----------V---------------YGFGCEDSLNH----LLNYVWPNVFET-------------SPH-VIQAVMGALEGLRVAIG-----------------------------PCRMLQYCLQGLF-------------------------HPARKVRDVYWKIY---NSIYIGSQDALIAHYPRIYND---------DKNTY----IR--YELDYIL------------------------------------------------------
21 Fugue 37.0816% -4 - C6 - - 5IM3 ? A:[32-912] -----LRVIKRNGTVVPYTDDKITVAITKA-----FLAVE-----------GGTAAASSRIHDTVRR--LTEQVTATFKRRMPSG-GTIHIEEIQD----QVELALMRAG-------------------------------------------EQKVARDYVIYR----EARAAERKNAGAASDVA----QP------HPSIRITRADGSLSPLDMGRLNTIISEACEGLAEV-DGALIERETLK---NLYD----------GVAEKDVNTALVMTARTLVE---------REPNYSYVTARLLMD--------TLRAEALGFL------------GVAESATHHEMAELY--AKALPAY---------IEKG-AEFELVD-----------AKLKEFDLEKLGKAIDH--ERDQQ-FTYLGLQTLYDRYFIHKDGIRFELPQIFFMRVAM--GLAIEE----------------------KDREARAIEFY---NLLSSF---------------DYMS------STP-TLFNA---GTLRPQLS------SCYLTTVPDDLSGIYG-------AIHD-----------NAMLSK---FAGG-LGNDWTPVRALGSYIKGTNGKSQG-------------------------------VVPFLKVVNDTAVA--V-----NAVCA----YLETWHL------DIEEF--------LELRKNTGD----D-------RRRTHDMNTA-------------N------WIP---------------D--------LFMK---RVFDDGSWTLFSPSDVPDLHDLYGKAFEERYEY----------YEA-LASYGKLKLHK----VVQAKDLW-RKMLSMLFETGHPWLTF-----------KDPCNLRSPQQHVGVVHSSNLCT------EITLN-----------------TNKDEIAVC-NL--------GSIN-LVNH-----IVDGKLDTAKL--EKTVK---TAVRMLDNV-IDINYYSV---------PQAQNSNFKHRPVG-LGIMGFQ--DAL-------YLQ----HIPYGSD-----------AAIAFADQS----M-------------E------AI--S-YYA---------IQASCD---LADER--------GAY--QTFQG------------------SL-W----------SQGILPIDSEKKL-IE---E-RGA------------KYI------E------V-----------D---------LSETLDWAPLRERVQKG----IRNSNIMAIAPTA-----TIANITGVSQ-SIEPTYQNLYVKSNLSGEFTVINPYLVRDLKAR---------------------------------GLWDPVMV----NDLKYYDGSVQQIERIPQDL---KDLYATAFEVETRWIVEAASRRQKWIDQ-------------------AQSL--NLYIAGA---SGKKLDVTYRMAWFR-GLKTTYYLRALAAT-----------
22 Fugue 35.9314% -12 - C4 - - 1UF2 - P3_RDVA A:[50-1016] QSVVSRTPIPLSKIGL---QD-----------------VKKLFDI-NVIKCGSSLRIVD------EP--QVTFIVSY-----AKD-IYDKFMCIEHDSAYEPSLTMHRVRVIYSMLND------YCAKMISEVPYESSFVG----------------ELPVKSVT----LNKLGDRNMDALAEHLL----FEHDV---VNAQRENRIFYQRKSAPAVPVI-FGDDLEPAVRER-ANLYHRYSVPYHQIELAL----------HALAN-DLLSIQYCHPTVVY---------NYLSSRAP-NFLRLD--------DQVSLKLTSA--GI-G--TLMPRPVVQLLDYDLVYMS--PLALNNLASRLLRKISLHLV-MQMVTAVQ-QDLG--EVVSVSSNVTNPASACLVRM--NVQGVQTLAVFIAQSMLNPNISYGMIS---GLTLDCFSNF--IYGACLMLFQALIPPS--ALTARQRLDINNRFAYFLIKCHATQATTARLVANQVIY------PVDAI------DQW-QSNGRDVLVAIYNNLLPGELVLTNLIQTYFRGNTAQQA-------AEILIPADQTSYGANETRALSAPYLF-G-APINMLAPDARLSTYKRDLALPDR----SPILITTVEGQNS-------IS--IE-NLRHKTGLIRA---------------M----YLNGFVT------Q------------------------------------------------------------------PPAWIRNANSNTALLS--------RFLD---ATPN-LLGIY--EAIL---------------AN----------TYA-NAVN-----------------------------------VY-----------CDSVYRA---------DIPIEWK-----LHQSVD----------P--QDLLFGVFGIVPQYQI--------------LNE-----AVPDFFAGGED--ILILQLIRAVYDTLSNK-LGRNPADIF------HLEEVFKVIEEIVSVL-VQQKIDV--RKY-------FTESMRSGSFSK-P-----------RWDNFLRRP----V-------------A------QR--LPNLY---------SVIMTQ---ADHVYNYMT--QLTHI-IPITDC------------------FYIVKNSGFVDRGSTGPVIASSSVYENVLK---V-VHTIADFDAANALRLQRR------R------V-----------D-NTSYTDSLSDMFNGLRSISSSEFVR----SVNGRSVFTEGRI-----DAIKVNMRAK-FDLQFITEEGGYSKPPNVKKLMFSDFLSFLDSHKSDYRPP--------LLTVPITIGLNNL-----------------GETNS-------------------NTLRMRSEAIDEYFSSYVGAQILVPINVVDTRVY----TE--FSELRNFFTGDVVIRDDPFDVWDGVKA----TYIPIGVHGVRLDPNGDQ------------
15 Fugue 33.408% -30 - C7 - - 3P8C CYFP1_HUMAN A:[5-1250] ----------VTLEDA---LSNVDLLEELP-----LARYIEQATV-HSSMNEMLEEGQEYAVMLY----TWRSCSRAIPQVKCNE-QPNRVEIYEK----TVEVLEPEVTKLMNFMYFQRNAIERFCGEVRRL-CHAERRKDFVSEAYLITLGKFINMFAVLDEL----KNMKCSVKNDHSAYKRA----AQFLRKMADPQSIQESQNLSMFLANHNKITQSLQQQLEVISGY-EELLADIVNLCVDYYENR----------MYLTPSEKHMLLKVMGFGLY---------LMDGSVS-----NIY--------KLDAKKRINL--SKID--KYFKQLQVVPLFGDMQIEL--ARYIKTSA-HYEE---NKSR-WTCTSSIC-EQMI--QIREDHMRFISELARYSAQK--TDAEYRKLFDLALQGLQLLSQWSAHVM---EVYSWKLVHPTDKYSNKDCPDSAEEYER--ATRYNYTSEEKFALVEVIAMI---KGLQVLMGRMESVF------NHAIR------HTVYAALQDFSQVTLREPLRQAIKKKKNVIQSVLQAIRKTVC-------DWET-----------GHEPFN---DP-A-LRGEKDPFDIKVPRRAVGPSSTQL----Y--MVRTMLESLIAKTLRSSLE--GP-TILDIEKFHRESFF--Y-----THLIN----FSETLQQCCDLSQLWFRE--------FFLELTMGRRIQFP-------IEMSMPWILT-------------D------HILETKEASMMEYVLYSLD--------LYND---SAHYALTRFN--KQFLYDEIEAEVNLCFDQFVY----------KLA-DQIFAYYKVMA----GSLLLDKR-LRSECKNQGATIHLPPS-----------N-RYETLLKQ--------RHVQL-----LGRSID----------L--NRLITQRVSAAMYKSL--------ELAI-GRFESEDLTSIVELDGLLEI--NRMTHKLLSRYLTLDGF-DAMFREA---NHNVSAPYGRITLHVFWELNYDFLPNYCY--NGS-------TNRFVRTVLPFS-QEFQRDKQPNAQPQYLHGSKA----L-------------N------LA--Y-SSI---------YGSYRNFVGPPHFQVICR--LLGYQGIAVVME------------------ELLKVVKSLLQG--TILQYVKTLMEVM-PK---I-CRLPRHEYGSPGILEFFH------H------QLKDIVEYAELKT-VCFQNLREVGNAILFCLLIEQSLSL----EEVCDLLHAAPFQNILPRVHVKEGERLD-AKMKRLESKYAPLHLVPLIERLGTPQQIAIAREGDLLTKERLCCGLSMFEVILTRIR-SFLDDPIWRGPLPSNGVMHVDECVEFHRLWSAMQFVYCIP---VGTHEFTVEQCFGDGLHWAGCMIIVLLGQQRRFAVLDFCYH--LLKVQKHD--GKDEIIKNVPLKKMVERIRKFQILNDEIITILDKYLKEHVRCFQPPIHQSL
6 HHSearch 33.1715% -23 - C7 - - 4N78 CYFP1_HUMAN A:[751-1038] ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KQRHVQL-----LGRSID----------L--NRLITQRVSAAMYKSL--------ELAIGRF-------ESEDLTSIVEL--DGLLEINRMTHKLLSRY-LTLDGFDAMFREANHNVSAP---YG---RIT-LHVFWELNYDFL-------P------NYCYN-G-----------STNRFVRTV----LPFSQEFQRDKQPNAQPQYLHGS--K-ALNLAYSSIYGSYRNFVG---PPHFQVICR--LLGYQGIAVVME------------------ELLKVVKSLLQG--TILQYVKTLMEVM-PKICRLPRHEYGSPGILEFFHHQLKDIVEYAE------L-----------KTVCFQNLREVGNAILFCLLIEQSLSLEEVCDLLHAAPFQ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10 HHSearch 32.2611% -39 - C7 - - 4PS2 - ? A:[16-52] --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PEQVARQIP---RLKAMLAM-RSLL-RD---L-KANLLDNVTFRKE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5 HHSearch 31.7815% -20 - C7 - - 3P8C CYFP1_HUMAN A:[751-1038] ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KQRHVQL-----LGRSID----------L--NRLITQRVSAAMYKSL--------ELAIGRF-------ESEDLTSIVEL--DGLLEINRMTHKLLSRY-LTLDGFDAMFREANHNVSAP---YG---RIT-LHVFWELNYDFL-------P------NYCYN-G-----------STNRFVRTV----LPFSQEFQRDKQPNAQPQYLHGS--K-ALNLAYSSIYGSYRNFVG---PPHFQVICR--LLGYQGIAVVME------------------ELLKVVKSLLQG--TILQYVKTLMEVM-PKICRLPRHEYGSPGILEFFHHQLKDIVEYAE------L-----------KTVCFQNLREVGNAILFCLLIEQSLSLEEVCDLLHAAPFQ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3 PsiBlast_PDB 31.2824%-113 - C7 - - 3CK6 - ? A:[50-206] -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NHVPRA-T---VDHLLADESRPSFHPLDDDNFMLILRGINMNENASPEDMLSIRILYFQGALISTRKIPSRAIMEIRQALA----EH-KGPKSLASLLNQIIEGLNGKIDLYLDTIEETLNEFDVNDESTYNHIAAQKALISI----KRFIRPQQYAIR--DLIESESELVT----------------------------------------
16 Fugue 31.1814% 27 - C3 - - 4CMP - CAS9_STRP1 A:[8-1367] --KYSIGLDIGT--------------NSVG-----WAVITDEYKVPSKKFKVLGNTDRHSIKKNLIG--ALLF-----DSGETAE-ATRLKRTARR----RYTRRKNRICYLQEIFSNEMAKVDD--SFFHRLERHPIFGNIVDEVAYHEKYPTIYHLRKKLVDS----TDKADLRLIYLALAHMIKFRGHFLIE---GDLNPDNSDVDKLFIQLVQTYNQLFEENPINASGVDAKAILSARLSKSRRLENLIAQLPGEKKNGLFGNLIALSLGLTPNFKSNFDLAEDAKLQLSKDTYDDDLDNLL--------AQIGDQYADL--FLAA--KNLSDAILLSDILRKAPLS--ASMIKRYDEHHQD---LTLL-KALVRQQLPEKYK--EIFFDQSKNGYAGYIDGGAS--QEEFYKFIKPILEKMD----------G---TEELLVKLN------REDLLRKQRTFDNGSIPHQIHLGELHAILRRQEDFY---PFLKDNREKIEKILTFRPNEKVLPK------HSL-LYEYFTVYNELTKVLS--GEQKKAIVDLLFKTNRKVTV-------KQLK-----------E----D---FN-A-SLGTYHDLLKIIK----DKDFLDN----E--ENEDILEDIV-------LT--LT-LFED-REMIEERLK--T-----YAHLF----DDKVMKQ------LKRRRYTGWGRLSRKLINGIRDKTILD-------FLKRNFMQLI-------------HDDSLTFKEDIQKAQVSDSLHEHIAN--------LAGS---PAIKKGILQT--VKVVDELVKVMGRHKPENIVI----------EMAKNSRERMKRIEE----GIKELHPV-ENTQLQNEKLYLYYLQNGRDMYVDQELDINRLSDYDVDHIVPQSFLKDDSI-----DNKVLTRKNRGKSDNVP--SEEVVKKMKNYWRQLL--------NAKL-ITQR-----KFDNLTKLSELDKAGFIKRQLVETRQITKH-VAQILDSRM-NTKYDENDKLIREVKVITLKS-KLVSDFR--KDFQFYKVREINNYHHAHDAYL-N-----------AVVGTALIKKYPKL-------------E------SE--F-VYG---------DYKVYD---VRKMIAKSEQYFFYSNIMNFFKT------------------EIT--LANGEI---RKRPLIETNGE----T---G-EIVWDKGRDFATVRKVLS------M------P-----------Q-VNIVKKTEVQTPTVAYSVLVVSVKE----LLGITIMERSSFE-----KNPIDFLEAKGKDLIIKLPKY-------SLFELENGRKRMLASAGELQKGNELALPSKYVNFLYLASHYVEQHKHYLDEIIEQIS----EFSKRVILADANLDKVLSAY---NKHRDKPIREQAENIIHLFTLTNL----------------G--APAAFKYF--DTTIDRKRYTSTKEVLDA---TLIHQSITGLYETRIDLS------------
9 HHSearch 30.2123% -25 - C7 - - 2MN2 - ? A:[4-83] -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YS---------PK-RHD---VAQLKFLCE--SLYDEGIATLGDSHHGWVNDPTSAVNLQLNDLIEHIASFVM---SFKIKYPDDGDLS-EL---V-EEYLDDT-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13 HHSearch 27.4124%-128 - C7 - - 1KON - YEBC_ECOLI A:[85-125] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IIYE--GYGPGGTAIMIE------------------CLSDNRNRTVA---EVRHAFSKCGGNL-G--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20 Fugue 26.8618% 10 - C2 - - 5DNK Y789_RICPR A:[45-554] --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ESYPYAITN-PYHLSTLATLF---GINA----------PEVENSKILELGCAAGGNLI---------PHAVLYPNAHFVGVDLSKVQIDEANKNVRALGLKNIEFHHCSITDIDDSFGKFDYIICHGVISWVPKIVRDKIFK---VCNRNLSTNGIAY-ISYNTLPGWNMVRTIRDMMLYHSSSFTNIRDRIAQSRLLLEFVKDSLEHSKT------PYAEVLKTEA--GLLAKQTDHYLRH-DH--LEEENAQ-----------FYF---HEFMNEARKHN---------LQYLADCNISTMYL-GNMPPKVVEQLKAVNDIVRTEQYMDFITNRRFRTTLLCHNDLKINRNIN-----------NDDIKK---FN-I-I----FNVIPEKPLKEVDLNNATENLQFF--LNGNKESNLS-------TT--SP-YMKAILYTFSENLNNPL-----SFKQV----TSEANTK------LNNTK--------LNEIKNELLNNAMK-------LVLQGYISIT-------------N------Q---KHRSKPVLDKPKTTQ--------MVIY---QAKYTPSMWV--TNLKHEPIGVN--FFEKFALR----------YMD-GRNDKKAIIEAILGHVEKGELTL-SREGQKIENKEE-IRKE-----------LESLFTPMIEKFCSNALLV------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19 Fugue 24.4916% 23 - C1 - - 4BHW EP300_HUMAN A:[14-576] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KKIFKPEELRQALMPTLEALYR-------Q--------------DPESLP---FR-QPVDPQLLGIPDYFDIVKSPM---DL----S--TIKRKLDTGQ-------YQEPWQ-YVDDIWLMFNNAWL--YNRKTSRVYKY----CSKLSEV------FEQEI--------DPVMQSLGYCCGRKLEFSPQTLCCYGKQLCTIPRDATYYSYQNRY------HFCEKCFNEIQGESVSLGDDPSQPQTTINKE---QFSKRKNDTL--DPELFVECTECGRKMHQICVLHHEIIWPAGFVCD-GCLKKSARTRK----ENKFSAKRLPSTRLGTFLENRVNDFL-----------RRQNHPESGEVTVRVVHASDKTVEVKPGMKARFV----------D--SGEMAESFPYR-TKALFAFEEIDGVDLC-FFGM-----HVQEYGSDCPP--PNQRRVYISYLDSVHFFRPKCLRTAVY-HEILIGYLEYVKKLG--------YT---------------------TGHIWAC-P-------------------P----S-------------E------GDDYI-FHC---------HPPDQK---IPKPKRLQE--WFKKMLDKAVSE------------------RIVHDYKDIFK---QATEDRLTSAKEL-PY---F-EGDF-WPNVLEESIKESG------GSGSQKLY-----------A-TMEKHKEVFFVIRLIAGPAANSLPP----IVDPDPLIPCDLM-----DG------RD-AFLTLARDKHLEFSSLRRAQWSTMCMLVELHTQSQD-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11 HHSearch 24.1112% -99 - C7 - - 1LFP - Y1575_AQUAE A:[85-125] ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VIYE--GYAPGGVAVMVL------------------ATTDNRNRTTS---EVRHVFTKHGGNL-G--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------