@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : P5CR1_HUMAN: (2018-07-13 )
MSVGFIGAGQLAFALAKGFTAAGVLAAHKIMASSPDMDLATVSALRKMGVKLTPHNKETVQHSDVLFLAVKPHIIPFILDEIGADIEDRHIVVSCAAGVTISSIEKKLSAFRPAPRVIRCMTNTPVVVREGATVYATGTHAQVEDGRLMEQLLSSVGFCTEVEEDLIDAVTGLSGSGPAYAFTALDALADGGVKMGLPRRLAVRLGAQALLGAAKMLLHSEQHPGQLKDNVSSPGGATIHALHVLESGGFRSLLINAVEASCIRTRELQSMADQEQVSPAAIKKTILDKVKLDSPAGTALSPSGHTKLLPRSLAPAGKD
Atome Classification :
(20 SA)
.........10........20........---30--.........40......-..50........60........70........80.....--...-90........100.......110.......120.......130.......140.......150.......160.-......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MSVGFI
G
A
G
Q
L
A
F
A
L
A
KG
F
T
A
A
G
V
L
A
A
H
K
---
I
---MASSPD
M
D
L
A
T
V
S
A
L
R
K-MG
V
K
LTPHNKETVQHS
D
V
L
F
L
AVKP
H
I
I
P
F
I
L
D
E
IGADI--ED
R
-
H
I
V
V
SCAAGV
T
I
S
S
I
E
K
K
L
S
AFRPAP
R
V
I
R
CMTNT
P
V
V
V
REG
A
T
V
Y
ATGTHAQVED
G
R
L
M
E
Q
L
L
S
SVG
F
C
T
E
V
E
-
E
D
L
I
D
A
V
TGLSGSGP
A
Y
A
F
T
A
L
D
A
L
ADGGVKMGL
P
R
R
L
A
V
R
L
G
A
Q
A
L
L
G
A
A
K
M
L
L
HSEQHP
G
Q
L
KDNVSSPGG
A
T
I
H
A
L
H
V
LESG
G
F
R
S
L
L
I
N
A
V
E
A
S
C
I
R
T
R
E
L
Q
S
M
A
D
Q
EQV
S
P
A
A
I
K
K
T
I
L
D
K
VKLDSPAGTALSPSGHTKLL
P
R
SLAPAGKD
4
PsiBlast_PDB
97.12
100%
-137
- C1 -
-
5UAU
3
P5CR1_HUMAN
A:
[23-296]
M
S
V
G
F
I
G
A
G
Q
L
A
F
A
L
A
K
G
F
T
A
A
G
V
L
A
A
H
K
---
I
---
M
A
S
S
P
D
M
D
L
A
T
V
S
A
L
R
K
-
M
G
V
K
L
T
P
H
N
K
E
T
V
Q
H
S
D
V
L
F
L
A
V
K
P
H
I
I
P
F
I
L
D
E
I
G
A
D
I
--
E
D
R
-
H
I
V
V
S
C
A
A
G
V
T
I
S
S
I
E
K
K
L
S
A
F
R
P
A
P
R
V
I
R
C
M
T
N
T
P
V
V
V
R
E
G
A
T
V
Y
A
T
G
T
H
A
Q
V
E
D
G
R
L
M
E
Q
L
L
S
S
V
G
F
C
T
E
V
E
-
E
D
L
I
D
A
V
T
G
L
S
G
S
G
P
A
Y
A
F
T
A
L
D
A
L
A
D
G
G
V
K
M
G
L
P
R
R
L
A
V
R
L
G
A
Q
A
L
L
G
A
A
K
M
L
L
H
S
E
Q
H
P
G
Q
L
K
D
N
V
S
S
P
G
G
A
T
I
H
A
L
H
V
L
E
S
G
G
F
R
S
L
L
I
N
A
V
E
A
S
C
I
R
T
R
E
L
Q
S
M
A
D
Q
---------------------------------------------
9
PsiBlast_PDB
94.91
100%
-144
- C1 -
-
5UAX
-
P5CR1_HUMAN
A:
[9-278]
M
S
V
G
F
I
G
A
G
Q
L
A
F
A
L
A
K
G
F
T
A
A
G
V
L
A
A
H
K
---
I
---
M
A
S
S
P
D
M
D
L
A
T
V
S
A
L
R
K
-
M
G
V
K
L
T
P
H
N
K
E
T
V
Q
H
S
D
V
L
F
L
A
V
K
P
H
I
I
P
F
I
L
D
E
I
G
A
D
I
--
E
D
R
-
H
I
V
V
S
C
A
A
G
V
T
I
S
S
I
E
K
K
L
S
A
F
R
P
A
P
R
V
I
R
C
M
T
N
T
P
V
V
V
R
E
G
A
T
V
Y
A
T
G
T
H
A
Q
V
E
D
G
R
L
M
E
Q
L
L
S
S
V
G
F
C
T
E
V
E
-
E
D
L
I
D
A
V
T
G
L
S
G
S
G
P
A
Y
A
F
T
A
L
D
A
L
A
D
G
G
V
K
M
G
L
P
R
R
L
A
V
R
L
G
A
Q
A
L
L
G
A
A
K
M
L
L
H
S
E
Q
H
P
G
Q
L
K
D
N
V
S
S
P
G
G
A
T
I
H
A
L
H
V
L
E
S
G
G
F
R
S
L
L
I
N
A
V
E
A
S
C
I
R
T
R
E
L
Q
S
-------------------------------------------------
5
PsiBlast_PDB
94.49
100%
-136
- C1 -
-
5UAV
3
P5CR1_HUMAN
A:
[23-296]
M
S
V
G
F
I
G
A
G
Q
L
A
F
A
L
A
K
G
F
T
A
A
G
V
L
A
A
H
K
---
I
---
M
A
S
S
P
D
M
D
L
A
T
V
S
A
L
R
K
-
M
G
V
K
L
T
P
H
N
K
E
T
V
Q
H
S
D
V
L
F
L
A
V
K
P
H
I
I
P
F
I
L
D
E
I
G
A
D
I
--
E
D
R
-
H
I
V
V
S
C
A
A
G
V
T
I
S
S
I
E
K
K
L
S
A
F
R
P
A
P
R
V
I
R
C
M
T
N
T
P
V
V
V
R
E
G
A
T
V
Y
A
T
G
T
H
A
Q
V
E
D
G
R
L
M
E
Q
L
L
S
S
V
G
F
C
T
E
V
E
-
E
D
L
I
D
A
V
T
G
L
S
G
S
G
P
A
Y
A
F
T
A
L
D
A
L
A
D
G
G
V
K
M
G
L
P
R
R
L
A
V
R
L
G
A
Q
A
L
L
G
A
A
K
M
L
L
H
S
E
Q
H
P
G
Q
L
K
D
N
V
S
S
P
G
G
A
T
I
H
A
L
H
V
L
E
S
G
G
F
R
S
L
L
I
N
A
V
E
A
S
C
I
R
T
R
E
L
Q
S
M
A
D
Q
---------------------------------------------
8
PsiBlast_PDB
94.20
100%
-140
- C1 -
-
2GRA
1
P5CR1_HUMAN
A:
[3-277]
M
S
V
G
F
I
G
A
G
Q
L
A
F
A
L
A
K
G
F
T
A
A
G
V
L
A
A
H
K
---
I
---
M
A
S
S
P
D
M
D
L
A
T
V
S
A
L
R
K
-
M
G
V
K
L
T
P
H
N
K
E
T
V
Q
H
S
D
V
L
F
L
A
V
K
P
H
I
I
P
F
I
L
D
E
I
G
A
D
I
--
E
D
R
-
H
I
V
V
S
C
A
A
G
V
T
I
S
S
I
E
K
K
L
S
A
F
R
P
A
P
R
V
I
R
C
M
T
N
T
P
V
V
V
R
E
G
A
T
V
Y
A
T
G
T
H
A
Q
V
E
D
G
R
L
M
E
Q
L
L
S
S
V
G
F
C
T
E
V
E
-
E
D
L
I
D
A
V
T
G
L
S
G
S
G
P
A
Y
A
F
T
A
L
D
A
L
A
D
G
G
V
K
M
G
L
P
R
R
L
A
V
R
L
G
A
Q
A
L
L
G
A
A
K
M
L
L
H
S
E
Q
H
P
G
Q
L
K
D
N
V
S
S
P
G
G
A
T
I
H
A
L
H
V
L
E
S
G
G
F
R
S
L
L
I
N
A
V
E
A
S
C
I
R
T
R
E
L
Q
S
M
A
D
Q
E
--------------------------------------------
1
PsiBlast_PDB
93.32
100%
-140
- C1 -
-
2GER
-
P5CR1_HUMAN
A:
[1-275]
M
S
V
G
F
I
G
A
G
Q
L
A
F
A
L
A
K
G
F
T
A
A
G
V
L
A
A
H
K
---
I
---
M
A
S
S
P
D
M
D
L
A
T
V
S
A
L
R
K
-
M
G
V
K
L
T
P
H
N
K
E
T
V
Q
H
S
D
V
L
F
L
A
V
K
P
H
I
I
P
F
I
L
D
E
I
G
A
D
I
--
E
D
R
-
H
I
V
V
S
C
A
A
G
V
T
I
S
S
I
E
K
K
L
S
A
F
R
P
A
P
R
V
I
R
C
M
T
N
T
P
V
V
V
R
E
G
A
T
V
Y
A
T
G
T
H
A
Q
V
E
D
G
R
L
M
E
Q
L
L
S
S
V
G
F
C
T
E
V
E
-
E
D
L
I
D
A
V
T
G
L
S
G
S
G
P
A
Y
A
F
T
A
L
D
A
L
A
D
G
G
V
K
M
G
L
P
R
R
L
A
V
R
L
G
A
Q
A
L
L
G
A
A
K
M
L
L
H
S
E
Q
H
P
G
Q
L
K
D
N
V
S
S
P
G
G
A
T
I
H
A
L
H
V
L
E
S
G
G
F
R
S
L
L
I
N
A
V
E
A
S
C
I
R
T
R
E
L
Q
S
M
A
D
Q
E
--------------------------------------------
2
PsiBlast_PDB
92.18
100%
-139
- C1 -
-
2IZZ
5
P5CR1_HUMAN
A:
[23-293]
M
S
V
G
F
I
G
A
G
Q
L
A
F
A
L
A
K
G
F
T
A
A
G
V
L
A
A
H
K
---
I
---
M
A
S
S
P
D
M
D
L
A
T
V
S
A
L
R
K
-
M
G
V
K
L
T
P
H
N
K
E
T
V
Q
H
S
D
V
L
F
L
A
V
K
P
H
I
I
P
F
I
L
D
E
I
G
A
D
I
--
E
D
R
-
H
I
V
V
S
C
A
A
G
V
T
I
S
S
I
E
K
K
L
S
A
F
R
P
A
P
R
V
I
R
C
M
T
N
T
P
V
V
V
R
E
G
A
T
V
Y
A
T
G
T
H
A
Q
V
E
D
G
R
L
M
E
Q
L
L
S
S
V
G
F
C
T
E
V
E
-
E
D
L
I
D
A
V
T
G
L
S
G
S
G
P
A
Y
A
F
T
A
L
D
A
L
A
D
G
G
V
K
M
G
L
P
R
R
L
A
V
R
L
G
A
Q
A
L
L
G
A
A
K
M
L
L
H
S
E
Q
H
P
G
Q
L
K
D
N
V
S
S
P
G
G
A
T
I
H
A
L
H
V
L
E
S
G
G
F
R
S
L
L
I
N
A
V
E
A
S
C
I
R
T
R
E
L
Q
S
M
------------------------------------------------
7
PsiBlast_PDB
92.05
100%
-140
- C1 -
-
2GR9
1
P5CR1_HUMAN
A:
[3-277]
M
S
V
G
F
I
G
A
G
Q
L
A
F
A
L
A
K
G
F
T
A
A
G
V
L
A
A
H
K
---
I
---
M
A
S
S
P
D
M
D
L
A
T
V
S
A
L
R
K
-
M
G
V
K
L
T
P
H
N
K
E
T
V
Q
H
S
D
V
L
F
L
A
V
K
P
H
I
I
P
F
I
L
D
E
I
G
A
D
I
--
E
D
R
-
H
I
V
V
S
C
A
A
G
V
T
I
S
S
I
E
K
K
L
S
A
F
R
P
A
P
R
V
I
R
C
M
T
N
T
P
V
V
V
R
E
G
A
T
V
Y
A
T
G
T
H
A
Q
V
E
D
G
R
L
M
E
Q
L
L
S
S
V
G
F
C
T
E
V
E
-
E
D
L
I
D
A
V
T
G
L
S
G
S
G
P
A
Y
A
F
T
A
L
D
A
L
A
D
G
G
V
K
M
G
L
P
R
R
L
A
V
R
L
G
A
Q
A
L
L
G
A
A
K
M
L
L
H
S
E
Q
H
P
G
Q
L
K
D
N
V
S
S
P
G
G
A
T
I
H
A
L
H
V
L
E
S
G
G
F
R
S
L
L
I
N
A
V
E
A
S
C
I
R
T
R
E
L
Q
S
M
A
D
Q
E
--------------------------------------------
31
HHSearch
91.07
100%
-141
- C1 -
-
2GRA
1
P5CR1_HUMAN
D:
[3-277]
M
S
V
G
F
I
G
A
G
Q
L
A
F
A
L
A
K
G
F
T
A
A
G
V
L
A
A
H
K
---
I
---
M
A
S
S
P
D
M
D
L
A
T
V
S
A
L
R
K
-
M
G
V
K
L
T
P
H
N
K
E
T
V
Q
H
S
D
V
L
F
L
A
V
K
P
H
I
I
P
F
I
L
D
E
I
G
A
D
I
--
E
D
R
-
H
I
V
V
S
C
A
A
G
V
T
I
S
S
I
E
K
K
L
S
A
F
R
P
A
P
R
V
I
R
C
M
T
N
T
P
V
V
V
R
E
G
A
T
V
Y
A
T
G
T
H
A
Q
V
E
D
G
R
L
M
E
Q
L
L
S
S
V
G
F
C
T
E
V
E
-
E
D
L
I
D
A
V
T
G
L
S
G
S
G
P
A
Y
A
F
T
A
L
D
A
L
A
D
G
G
V
K
M
G
L
P
R
R
L
A
V
R
L
G
A
Q
A
L
L
G
A
A
K
M
L
L
H
S
E
Q
H
P
G
Q
L
K
D
N
V
S
S
P
G
G
A
T
I
H
A
L
H
V
L
E
S
G
G
F
R
S
L
L
I
N
A
V
E
A
S
C
I
R
T
R
E
L
Q
S
M
A
D
Q
E
--------------------------------------------
3
PsiBlast_PDB
89.48
100%
-147
- C1 -
-
5UAT
-
P5CR1_HUMAN
A:
[23-296]
M
S
V
G
F
I
----
L
A
F
A
L
A
K
G
F
T
A
A
G
V
L
A
A
H
K
---
I
---
M
A
S
-------
T
V
S
A
L
R
K
-
M
G
V
K
L
T
P
H
N
K
E
T
V
Q
H
S
D
V
L
F
L
A
V
K
P
H
I
I
P
F
I
L
D
E
I
G
A
D
I
--
E
D
R
-
H
I
V
V
S
C
A
A
G
V
T
I
S
S
I
E
K
K
L
S
A
F
R
P
A
P
R
V
I
R
C
M
T
N
T
P
V
V
V
R
E
G
A
T
V
Y
A
T
G
T
H
A
Q
V
E
D
G
R
L
M
E
Q
L
L
S
S
V
G
F
C
T
E
V
E
-
E
D
L
I
D
A
V
T
G
L
S
G
S
G
P
A
Y
A
F
T
A
L
D
A
L
A
D
G
G
V
K
M
G
L
P
R
R
L
A
V
R
L
G
A
Q
A
L
L
G
A
A
K
M
L
L
H
S
E
Q
H
P
G
Q
L
K
D
N
V
S
S
P
G
G
A
T
I
H
A
L
H
V
L
E
S
G
G
F
R
S
L
L
I
N
A
V
E
A
S
C
I
R
T
R
E
L
Q
S
M
A
D
Q
---------------------------------------------
6
PsiBlast_PDB
87.94
100%
-140
- C1 -
-
5UAW
-
P5CR1_HUMAN
A:
[24-296]
-
S
V
G
F
I
G
A
G
Q
L
A
F
A
L
A
K
G
F
T
A
A
G
V
L
A
A
H
K
---
I
---
M
A
S
----------
A
L
R
K
-
M
G
V
K
L
T
P
H
N
K
E
T
V
Q
H
S
D
V
L
F
L
A
V
K
P
H
I
I
P
F
I
L
D
E
I
G
A
D
I
--
E
D
R
-
H
I
V
V
S
C
A
A
G
V
T
I
S
S
I
E
K
K
L
S
A
F
R
P
A
P
R
V
I
R
C
M
T
N
T
P
V
V
V
R
E
G
A
T
V
Y
A
T
G
T
H
A
Q
V
E
D
G
R
L
M
E
Q
L
L
S
S
V
G
F
C
T
E
V
E
-
E
D
L
I
D
A
V
T
G
L
S
G
S
G
P
A
Y
A
F
T
A
L
D
A
L
A
D
G
G
V
K
M
G
L
P
R
R
L
A
V
R
L
G
A
Q
A
L
L
G
A
A
K
M
L
L
H
S
E
Q
H
P
G
Q
L
K
D
N
V
S
S
P
G
G
A
T
I
H
A
L
H
V
L
E
S
G
G
F
R
S
L
L
I
N
A
V
E
A
S
C
I
R
T
R
E
L
Q
S
M
A
D
Q
---------------------------------------------
32
HHSearch
85.49
100%
-143
- C1 -
-
5UAX
-
P5CR1_HUMAN
E:
[9-277]
M
S
V
G
F
I
G
A
G
Q
L
A
F
A
L
A
K
G
F
T
A
A
G
V
L
A
A
H
K
---
I
---
M
A
S
S
----------------
V
K
L
T
P
H
N
K
E
T
V
Q
H
S
D
V
L
F
L
A
V
K
P
H
I
I
P
F
I
L
D
E
I
G
A
D
I
--
E
D
R
-
H
I
V
V
S
C
A
A
G
V
T
I
S
S
I
E
K
K
L
S
A
F
R
P
A
P
R
V
I
R
C
M
T
N
T
P
V
V
V
R
E
G
A
T
V
Y
A
T
G
T
H
A
Q
V
E
D
G
R
L
M
E
Q
L
L
S
S
V
G
F
C
T
E
V
E
-
E
D
L
I
D
A
V
T
G
L
S
G
S
G
P
A
Y
A
F
T
A
L
D
A
L
A
D
G
G
V
K
M
G
L
P
R
R
L
A
V
R
L
G
A
Q
A
L
L
G
A
A
K
M
L
L
H
S
E
Q
H
P
G
Q
L
K
D
N
V
S
S
P
G
G
A
T
I
H
A
L
H
V
L
E
S
G
G
F
R
S
L
L
I
N
A
V
E
A
S
C
I
R
T
R
E
L
Q
--------------------------------------------------
14
PsiBlast_PDB
67.13
37%
-76
- C1 -
-
3TRI
1
?
A:
[5-273]
-
N
I
T
F
I
G
G
G
N
M
A
R
N
I
V
V
G
L
I
A
N
G
-
Y
D
P
N
R
---
I
---
C
V
T
N
R
S
L
D
K
L
D
F
F
K
-
E
K
-
C
G
V
H
T
T
Q
D
N
R
Q
G
A
L
N
A
D
V
V
V
L
A
V
K
P
H
Q
I
K
M
V
C
E
E
L
-
K
D
I
L
S
E
T
K
-
I
L
V
I
S
L
A
V
G
V
T
T
P
L
I
E
K
W
L
G
---
K
A
S
R
I
V
R
A
M
P
N
T
P
S
S
V
R
A
G
A
T
G
L
F
A
N
E
T
V
D
K
D
Q
K
N
L
A
E
S
I
M
R
A
V
G
L
V
I
W
V
S
S
E
D
Q
I
E
K
I
A
A
L
S
G
S
G
P
A
Y
I
F
L
I
M
E
A
L
Q
E
A
A
E
Q
L
G
L
T
K
E
T
A
E
L
L
T
E
Q
T
V
L
G
A
A
R
M
A
L
E
T
E
Q
S
V
V
Q
L
R
Q
F
V
T
S
P
G
G
T
T
E
Q
A
I
K
V
L
E
S
G
N
L
R
E
L
F
I
K
A
L
T
A
A
V
N
R
A
K
E
L
S
K
T
V
D
----------------------------------------------
37
HHSearch
67.07
32%
-153
- C1 -
-
2RCY
3
?
A:
[5-262]
I
K
L
G
F
M
G
L
G
Q
M
G
S
A
L
A
H
G
I
A
N
A
N
I
I
K
K
E
N
---
L
---
F
Y
Y
G
P
S
K
K
N
--
T
-------
T
L
N
Y
M
S
S
N
E
E
L
A
R
H
C
D
I
I
V
C
A
V
K
P
D
I
A
G
S
V
L
N
N
I
K
P
Y
L
---
S
S
-
K
L
L
I
S
I
C
G
G
L
N
I
G
K
L
E
E
M
V
G
S
---
E
N
K
I
V
W
V
M
P
N
T
P
C
L
V
G
E
G
S
F
I
Y
C
S
N
K
N
V
N
S
T
D
K
K
Y
V
N
D
I
F
N
S
C
G
I
I
H
E
I
K
-
E
K
D
M
D
I
A
T
A
I
S
G
C
G
P
A
Y
V
Y
L
F
I
E
S
L
I
D
A
G
V
K
N
G
L
S
R
E
L
S
K
N
L
V
L
Q
T
I
K
G
S
V
E
M
V
K
K
S
D
Q
P
V
Q
Q
L
K
D
N
I
V
S
P
G
G
I
T
A
V
G
L
Y
S
L
E
K
N
S
F
K
Y
T
V
M
N
A
V
E
A
A
C
E
K
S
K
A
M
G
S
-------------------------------------------------
38
HHSearch
65.73
32%
-149
- C1 -
-
2RCY
2
?
C:
[5-262]
I
K
L
G
F
M
G
L
G
Q
M
G
S
A
L
A
H
G
I
A
N
A
N
I
I
K
K
E
N
---
L
---
F
Y
Y
G
P
S
K
K
N
--
T
-------
T
L
N
Y
M
S
S
N
E
E
L
A
R
H
C
D
I
I
V
C
A
V
K
P
D
I
A
G
S
V
L
N
N
I
K
P
Y
L
---
S
S
-
K
L
L
I
S
I
C
G
G
L
N
I
G
K
L
E
E
M
V
G
S
---
E
N
K
I
V
W
V
M
P
N
T
P
C
L
V
G
E
G
S
F
I
Y
C
S
N
K
N
V
N
S
T
D
K
K
Y
V
N
D
I
F
N
S
C
G
I
I
H
E
I
K
-
E
K
D
M
D
I
A
T
A
I
S
G
C
G
P
A
Y
V
Y
L
F
I
E
S
L
I
D
A
G
V
K
N
G
L
S
R
E
L
S
K
N
L
V
L
Q
T
I
K
G
S
V
E
M
V
K
K
S
D
Q
P
V
Q
Q
L
K
D
N
I
V
S
P
G
G
I
T
A
V
G
L
Y
S
L
E
K
N
S
F
K
Y
T
V
M
N
A
V
E
A
A
C
E
K
S
K
A
M
G
S
-------------------------------------------------
39
HHSearch
59.42
38%
-14
* C1 *
-
3TRI
1
?
A:
[4-272]
S
N
I
T
F
I
G
G
G
N
M
A
R
N
I
V
V
G
L
I
A
N
G
----
Y
D
PNR
I
---
C
V
T
N
R
S
L
D
K
--
L
D
F
F
K
E
K
C
G
V
H
T
T
Q
D
N
R
Q
G
A
L
N
A
D
V
V
V
L
A
V
K
P
H
Q
I
K
M
V
C
E
E
L
K
D
I
L
--
S
E
T
K
I
L
V
I
S
L
A
V
G
V
T
T
P
L
I
E
K
W
L
G
K
---
A
S
R
I
V
R
A
M
P
N
T
P
S
S
V
R
A
G
A
T
G
L
F
A
N
E
T
V
D
K
D
Q
K
N
L
A
E
S
I
M
R
A
V
G
L
V
I
W
V
S
S
E
D
Q
I
E
K
I
A
A
L
S
G
S
G
P
A
Y
I
F
L
I
M
E
A
L
Q
E
A
A
E
Q
L
G
L
T
K
E
T
A
E
L
L
T
E
Q
T
V
L
G
A
A
R
M
A
L
E
T
E
Q
S
V
V
Q
L
R
Q
F
V
T
S
P
G
G
T
T
E
Q
A
I
K
V
L
E
S
G
N
L
R
E
L
F
I
K
A
L
T
A
A
V
N
R
A
K
E
L
S
K
T
V
-----------------------------------------------
13
PsiBlast_PDB
58.14
42%
-54
- C1 -
-
5BSH
2
?
A:
[15-276]
-
T
L
G
F
I
G
A
G
K
M
A
E
S
I
A
K
G
A
V
R
S
G
V
L
S
P
S
R
---
I
K
T
A
I
H
S
N
P
----
A
R
R
T
A
F
E
S
-
I
G
I
T
V
L
S
S
N
D
D
V
V
R
D
S
N
V
V
V
F
S
V
K
P
Q
L
L
K
D
V
V
L
K
L
K
P
L
L
--
T
K
D
-
K
L
L
V
S
V
A
A
G
I
K
M
----
K
D
L
Q
E
W
A
G
H
E
R
F
I
R
V
M
P
N
T
A
A
T
V
G
E
A
A
S
V
M
S
L
G
G
A
A
T
E
E
D
A
N
L
I
S
Q
L
F
G
S
I
G
K
I
W
K
A
D
-
D
K
Y
F
D
A
I
T
G
L
S
G
S
G
P
A
Y
I
Y
L
A
I
E
A
L
A
D
G
G
V
A
A
G
L
P
R
D
L
A
L
S
L
A
S
Q
T
V
L
G
A
A
S
M
A
T
Q
S
G
K
H
P
G
Q
L
K
D
D
V
T
S
P
G
G
T
T
I
A
G
V
H
E
L
E
K
A
G
F
R
G
I
L
M
N
A
V
V
A
A
A
K
R
S
Q
E
L
---------------------------------------------------
11
PsiBlast_PDB
58.10
42%
-57
- C1 -
-
5BSF
3
?
A:
[15-276]
-
T
L
G
F
I
G
A
G
K
M
A
E
S
I
A
K
G
A
V
R
S
G
V
L
S
P
S
R
---
I
K
T
A
I
H
S
N
P
----
A
R
R
T
A
F
E
S
-
I
G
I
T
V
L
S
S
N
D
D
V
V
R
D
S
N
V
V
V
F
S
V
K
P
Q
L
L
K
D
V
V
L
K
L
K
P
L
L
--
T
K
D
-
K
L
L
V
S
V
A
A
G
I
K
M
----
K
D
L
Q
E
W
A
G
H
E
R
F
I
R
V
M
P
N
T
A
A
T
V
G
E
A
A
S
V
M
S
L
G
G
A
A
T
E
E
D
A
N
L
I
S
Q
L
F
G
S
I
G
K
I
W
K
A
D
-
D
K
Y
F
D
A
I
T
G
L
S
G
S
G
P
A
Y
I
Y
L
A
I
E
A
L
A
D
G
G
V
A
A
G
L
P
R
D
L
A
L
S
L
A
S
Q
T
V
L
G
A
A
S
M
A
T
Q
S
G
K
H
P
G
Q
L
K
D
D
V
T
S
P
G
G
T
T
I
A
G
V
H
E
L
E
K
A
G
F
R
G
I
L
M
N
A
V
V
A
A
A
K
R
S
Q
E
L
---------------------------------------------------
12
PsiBlast_PDB
57.81
42%
-56
- C1 -
-
5BSG
3
?
A:
[15-276]
-
T
L
G
F
I
G
A
G
K
M
A
E
S
I
A
K
G
A
V
R
S
G
V
L
S
P
S
R
---
I
K
T
A
I
H
S
N
P
----
A
R
R
T
A
F
E
S
-
I
G
I
T
V
L
S
S
N
D
D
V
V
R
D
S
N
V
V
V
F
S
V
K
P
Q
L
L
K
D
V
V
L
K
L
K
P
L
L
--
T
K
D
-
K
L
L
V
S
V
A
A
G
I
K
M
----
K
D
L
Q
E
W
A
G
H
E
R
F
I
R
V
M
P
N
T
A
A
T
V
G
E
A
A
S
V
M
S
L
G
G
A
A
T
E
E
D
A
N
L
I
S
Q
L
F
G
S
I
G
K
I
W
K
A
D
-
D
K
Y
F
D
A
I
T
G
L
S
G
S
G
P
A
Y
I
Y
L
A
I
E
A
L
A
D
G
G
V
A
A
G
L
P
R
D
L
A
L
S
L
A
S
Q
T
V
L
G
A
A
S
M
A
T
Q
S
G
K
H
P
G
Q
L
K
D
D
V
T
S
P
G
G
T
T
I
A
G
V
H
E
L
E
K
A
G
F
R
G
I
L
M
N
A
V
V
A
A
A
K
R
S
Q
E
L
---------------------------------------------------
10
PsiBlast_PDB
57.81
42%
-56
- C1 -
-
5BSE
1
?
A:
[15-276]
-
T
L
G
F
I
G
A
G
K
M
A
E
S
I
A
K
G
A
V
R
S
G
V
L
S
P
S
R
---
I
K
T
A
I
H
S
N
P
----
A
R
R
T
A
F
E
S
-
I
G
I
T
V
L
S
S
N
D
D
V
V
R
D
S
N
V
V
V
F
S
V
K
P
Q
L
L
K
D
V
V
L
K
L
K
P
L
L
--
T
K
D
-
K
L
L
V
S
V
A
A
G
I
K
M
----
K
D
L
Q
E
W
A
G
H
E
R
F
I
R
V
M
P
N
T
A
A
T
V
G
E
A
A
S
V
M
S
L
G
G
A
A
T
E
E
D
A
N
L
I
S
Q
L
F
G
S
I
G
K
I
W
K
A
D
-
D
K
Y
F
D
A
I
T
G
L
S
G
S
G
P
A
Y
I
Y
L
A
I
E
A
L
A
D
G
G
V
A
A
G
L
P
R
D
L
A
L
S
L
A
S
Q
T
V
L
G
A
A
S
M
A
T
Q
S
G
K
H
P
G
Q
L
K
D
D
V
T
S
P
G
G
T
T
I
A
G
V
H
E
L
E
K
A
G
F
R
G
I
L
M
N
A
V
V
A
A
A
K
R
S
Q
E
L
---------------------------------------------------
15
PsiBlast_PDB
56.68
30%
-151
- C1 -
-
2RCY
3
?
A:
[18-258]
-------------
A
L
A
H
G
I
A
N
A
N
I
I
K
K
E
N
---
L
---
F
Y
Y
G
P
S
K
K
N
T
T
L
N
---------
Y
M
S
S
N
E
E
L
A
R
H
C
D
I
I
V
C
A
V
K
P
D
I
A
G
S
V
L
N
N
I
K
P
Y
L
--
S
S
K
--
L
L
I
S
I
C
G
G
L
N
I
G
K
L
E
E
M
V
G
S
---
E
N
K
I
V
W
V
M
P
N
T
P
C
L
V
G
E
G
S
F
I
Y
C
S
N
K
N
V
N
S
T
D
K
K
Y
V
N
D
I
F
N
S
C
G
I
I
H
E
I
K
-
E
K
D
M
D
I
A
T
A
I
S
G
C
G
P
A
Y
V
Y
L
F
I
E
S
L
I
D
A
G
V
K
N
G
L
S
R
E
L
S
K
N
L
V
L
Q
T
I
K
G
S
V
E
M
V
K
K
S
D
Q
P
V
Q
Q
L
K
D
N
I
V
S
P
G
G
I
T
A
V
G
L
Y
S
L
E
K
N
S
F
K
Y
T
V
M
N
A
V
E
A
A
C
E
K
S
K
-----------------------------------------------------