@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PLK1_HUMAN: (2018-07-13 )
MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS
Atome Classification :
(23 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAP
P
A
K
E
I
P
E
V
LVD
P
R
S
R
R
R
Y
V
R
G
R
F
LGKGG
F
A
K
C
F
EISDAD
T
K
E
V
FAGKIV
P
K
S
LLLKPHQRE
K
M
S
M
E
I
S
I
H
R
S
L
A
H
Q
H
V
V
GFHGFFEDN
D
F
V
F
V
V
L
E
L
C
R
R
R
S
L
L
E
L
H
K
R
R
K
ALT
E
P
E
A
R
Y
Y
L
R
Q
I
V
L
G
C
Q
Y
L
H
RNR
V
I
H
R
DLKL
G
N
L
F
LNEDL
E
V
K
IGDFG
L
A
T
K
V
E
YDGERKKTLCGTPNYI
A
P
E
V
L
SKKG
H
S
F
E
V
D
V
W
S
I
G
C
I
M
Y
T
L
LVGKPPF
E
T
S
C
L
K
E
T
Y
L
R
IKKNEYSIPKHI
N
P
V
A
A
S
L
I
Q
K
M
L
QTDPTAR
P
T
I
N
E
L
LN
D
E
FFTSGYIPARL
P
I
T
C
L
TIPPRFSIAPSSLDPSNRK
P
L
T
V
L
N
K
GLENPLPERPREKEE
P
V
V
RETG
E
V
V
D
C
H
L
S
D
M
L
Q
Q
L
H
SVNASKPSERGLVRQEEAEDP
A
C
I
P
I
F
W
V
S
K
W
VDYSDKYG
L
G
Y
Q
LCDNS
V
G
V
L
FNDS
T
R
L
I
L
YNDGDS
L
Q
Y
I
ERDGTE
S
Y
L
T
VSSH
P
N
S
L
M
K
K
I
T
L
L
K
Y
F
R
N
Y
M
S
E
H
L
L
K
AGANITPREG
D
E
L
A
R
L
P
Y
L
R
T
W
F
RT
R
S
A
I
I
L
H
LSNG
S
V
Q
I
N
F
FQDHT
K
L
I
L
C
P
L
M
A
A
V
T
Y
I
DEKRD
F
R
T
Y
R
L
S
L
L
E
E
YG
C
C
K
E
L
A
S
R
L
R
Y
A
R
T
M
V
D
K
L
L
S
SRSASNRLKAS
4
PsiBlast_PDB
95.62
99%
-134
- C1 -
-
2OU7
1
PLK1_HUMAN
A:
[27-318]
------------------------------------
A
K
E
I
P
E
V
L
V
D
P
R
S
R
R
R
Y
V
R
G
R
F
L
G
K
G
G
F
A
K
C
F
E
I
S
D
A
D
T
K
E
V
F
A
G
K
I
V
P
K
S
L
L
L
K
P
H
Q
R
E
K
M
S
M
E
I
S
I
H
R
S
L
A
H
Q
H
V
V
G
F
H
G
F
F
E
D
N
D
F
V
F
V
V
L
E
L
C
R
R
R
S
L
L
E
L
H
K
R
R
K
A
L
T
E
P
E
A
R
Y
Y
L
R
Q
I
V
L
G
C
Q
Y
L
H
R
N
R
V
I
H
R
D
L
K
L
G
N
L
F
L
N
E
D
L
E
V
K
I
G
D
F
G
L
A
T
K
V
E
Y
D
G
E
R
K
K
V
L
C
G
T
P
N
Y
I
A
P
E
V
L
S
K
K
G
H
S
F
E
V
D
V
W
S
I
G
C
I
M
Y
T
L
L
V
G
K
P
P
F
E
T
S
C
L
K
E
T
Y
L
R
I
K
K
N
E
Y
S
I
P
K
H
I
N
P
V
A
A
S
L
I
Q
K
M
L
Q
T
D
P
T
A
R
P
T
I
N
E
L
L
N
D
E
F
F
T
S
G
Y
I
P
A
R
L
P
I
T
C
L
T
I
P
P
R
F
S
I
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
95.33
100%
-136
- C1 -
-
2OWB
1
PLK1_HUMAN
A:
[27-320]
------------------------------------
A
K
E
I
P
E
V
L
V
D
P
R
S
R
R
R
Y
V
R
G
R
F
L
G
K
G
G
F
A
K
C
F
E
I
S
D
A
D
T
K
E
V
F
A
G
K
I
V
P
K
S
L
L
L
K
P
H
Q
R
E
K
M
S
M
E
I
S
I
H
R
S
L
A
H
Q
H
V
V
G
F
H
G
F
F
E
D
N
D
F
V
F
V
V
L
E
L
C
R
R
R
S
L
L
E
L
H
K
R
R
K
A
L
T
E
P
E
A
R
Y
Y
L
R
Q
I
V
L
G
C
Q
Y
L
H
R
N
R
V
I
H
R
D
L
K
L
G
N
L
F
L
N
E
D
L
E
V
K
I
G
D
F
G
L
A
T
K
V
E
Y
D
G
E
R
K
K
V
L
C
G
T
P
N
Y
I
A
P
E
V
L
S
K
K
G
H
S
F
E
V
D
V
W
S
I
G
C
I
M
Y
T
L
L
V
G
K
P
P
F
E
T
S
C
L
K
E
T
Y
L
R
I
K
K
N
E
Y
S
I
P
K
H
I
N
P
V
A
A
S
L
I
Q
K
M
L
Q
T
D
P
T
A
R
P
T
I
N
E
L
L
N
D
E
F
F
T
S
G
Y
I
P
A
R
L
P
I
T
C
L
T
I
P
P
R
F
S
I
A
P
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
95.25
99%
-134
- C1 -
-
3FC2
7
PLK1_HUMAN
A:
[27-319]
------------------------------------
A
K
E
I
P
E
V
L
V
D
P
R
S
R
R
R
Y
V
R
G
R
F
L
G
K
G
G
F
A
K
C
F
E
I
S
D
A
D
T
K
E
V
F
A
G
K
I
V
P
K
S
L
L
L
K
P
H
Q
R
E
K
M
S
M
E
I
S
I
H
R
S
L
A
H
Q
H
V
V
G
F
H
G
F
F
E
D
N
D
F
V
F
V
V
L
E
L
C
R
R
R
S
L
L
E
L
H
K
R
R
K
A
L
T
E
P
E
A
R
Y
Y
L
R
Q
I
V
L
G
C
Q
Y
L
H
R
N
R
V
I
H
R
D
L
K
L
G
N
L
F
L
N
E
D
L
E
V
K
I
G
D
F
G
L
A
T
K
V
E
Y
D
G
E
R
K
K
V
L
C
G
T
P
N
Y
I
A
P
E
V
L
S
K
K
G
H
S
F
E
V
D
V
W
S
I
G
C
I
M
Y
T
L
L
V
G
K
P
P
F
E
T
S
C
L
K
E
T
Y
L
R
I
K
K
N
E
Y
S
I
P
K
H
I
N
P
V
A
A
S
L
I
Q
K
M
L
Q
T
D
P
T
A
R
P
T
I
N
E
L
L
N
D
E
F
F
T
S
G
Y
I
P
A
R
L
P
I
T
C
L
T
I
P
P
R
F
S
I
A
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
95.10
99%
-136
- C1 -
-
4J52
1
PLK1_HUMAN
A:
[1-293]
-------------------------------------
K
E
I
P
E
V
L
V
D
P
R
S
R
R
R
Y
V
R
G
R
F
L
G
K
G
G
F
A
K
C
F
E
I
S
D
A
D
T
K
E
V
F
A
G
K
I
V
P
K
S
L
L
L
K
P
H
Q
R
E
K
M
S
M
E
I
S
I
H
R
S
L
A
H
Q
H
V
V
G
F
H
G
F
F
E
D
N
D
F
V
F
V
V
L
E
L
C
R
R
R
S
L
L
E
L
H
K
R
R
K
A
L
T
E
P
E
A
R
Y
Y
L
R
Q
I
V
L
G
C
Q
Y
L
H
R
N
R
V
I
H
R
D
L
K
L
G
N
L
F
L
N
E
D
L
E
V
K
I
G
D
F
G
L
A
T
K
V
E
Y
D
G
E
R
K
K
V
L
C
G
T
P
N
Y
I
A
P
E
V
L
S
K
K
G
H
S
F
E
V
D
V
W
S
I
G
C
I
M
Y
T
L
L
V
G
K
P
P
F
E
T
S
C
L
K
E
T
Y
L
R
I
K
K
N
E
Y
S
I
P
K
H
I
N
P
V
A
A
S
L
I
Q
K
M
L
Q
T
D
P
T
A
R
P
T
I
N
E
L
L
N
D
E
F
F
T
S
G
Y
I
P
A
R
L
P
I
T
C
L
T
I
P
P
R
F
S
I
A
P
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
95.03
99%
-136
- C1 -
-
2OWB
1
PLK1_HUMAN
A:
[27-320]
------------------------------------
A
K
E
I
P
E
V
L
V
D
P
R
S
R
R
R
Y
V
R
G
R
F
L
G
K
G
G
F
A
K
C
F
E
I
S
D
A
D
T
K
E
V
F
A
G
K
I
V
P
K
S
L
L
L
K
P
H
Q
R
E
K
M
S
M
E
I
S
I
H
R
S
L
A
H
Q
H
V
V
G
F
H
G
F
F
E
D
N
D
F
V
F
V
V
L
E
L
C
R
R
R
S
L
L
E
L
H
K
R
R
K
A
L
T
E
P
E
A
R
Y
Y
L
R
Q
I
V
L
G
C
Q
Y
L
H
R
N
R
V
I
H
R
D
L
K
L
G
N
L
F
L
N
E
D
L
E
V
K
I
G
D
F
G
L
A
T
K
V
E
Y
D
G
E
R
K
K
V
L
C
G
T
P
N
Y
I
A
P
E
V
L
S
K
K
G
H
S
F
E
V
D
V
W
S
I
G
C
I
M
Y
T
L
L
V
G
K
P
P
F
E
T
S
C
L
K
E
T
Y
L
R
I
K
K
N
E
Y
S
I
P
K
H
I
N
P
V
A
A
S
L
I
Q
K
M
L
Q
T
D
P
T
A
R
P
T
I
N
E
L
L
N
D
E
F
F
T
S
G
Y
I
P
A
R
L
P
I
T
C
L
T
I
P
P
R
F
S
I
A
P
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
95.01
99%
-133
- C1 -
-
2RKU
6
PLK1_HUMAN
A:
[1-294]
------------------------------------
A
K
E
I
P
E
V
L
V
D
P
R
S
R
R
R
Y
V
R
G
R
F
L
G
K
G
G
F
A
K
C
F
E
I
S
D
A
D
T
K
E
V
F
A
G
K
I
V
P
K
S
L
L
L
K
P
H
Q
R
E
K
M
S
M
E
I
S
I
H
R
S
L
A
H
Q
H
V
V
G
F
H
G
F
F
E
D
N
D
F
V
F
V
V
L
E
L
C
R
R
R
S
L
L
E
L
H
K
R
R
K
A
L
T
E
P
E
A
R
Y
Y
L
R
Q
I
V
L
G
C
Q
Y
L
H
R
N
R
V
I
H
R
D
L
K
L
G
N
L
F
L
N
E
D
L
E
V
K
I
G
D
F
G
L
A
T
K
V
E
Y
D
G
E
R
K
K
V
L
C
G
T
P
N
Y
I
A
P
E
V
L
S
K
K
G
H
S
F
E
V
D
V
W
S
I
G
C
I
M
Y
T
L
L
V
G
K
P
P
F
E
T
S
C
L
K
E
T
Y
L
R
I
K
K
N
E
Y
S
I
P
K
H
I
N
P
V
A
A
S
L
I
Q
K
M
L
Q
T
D
P
T
A
R
P
T
I
N
E
L
L
N
D
E
F
F
T
S
G
Y
I
P
A
R
L
P
I
T
C
L
T
I
P
P
R
F
S
I
A
P
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
95.00
99%
-133
- C1 -
-
4J53
1
PLK1_HUMAN
A:
[1-293]
-------------------------------------
K
E
I
P
E
V
L
V
D
P
R
S
R
R
R
Y
V
R
G
R
F
L
G
K
G
G
F
A
K
C
F
E
I
S
D
A
D
T
K
E
V
F
A
G
K
I
V
P
K
S
L
L
L
K
P
H
Q
R
E
K
M
S
M
E
I
S
I
H
R
S
L
A
H
Q
H
V
V
G
F
H
G
F
F
E
D
N
D
F
V
F
V
V
L
E
L
C
R
R
R
S
L
L
E
L
H
K
R
R
K
A
L
T
E
P
E
A
R
Y
Y
L
R
Q
I
V
L
G
C
Q
Y
L
H
R
N
R
V
I
H
R
D
L
K
L
G
N
L
F
L
N
E
D
L
E
V
K
I
G
D
F
G
L
A
T
K
V
E
Y
D
G
E
R
K
K
V
L
C
G
T
P
N
Y
I
A
P
E
V
L
S
K
K
G
H
S
F
E
V
D
V
W
S
I
G
C
I
M
Y
T
L
L
V
G
K
P
P
F
E
T
S
C
L
K
E
T
Y
L
R
I
K
K
N
E
Y
S
I
P
K
H
I
N
P
V
A
A
S
L
I
Q
K
M
L
Q
T
D
P
T
A
R
P
T
I
N
E
L
L
N
D
E
F
F
T
S
G
Y
I
P
A
R
L
P
I
T
C
L
T
I
P
P
R
F
S
I
A
P
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
94.98
99%
-132
- C1 -
-
5TA8
1
PLK1_HUMAN
A:
[50-343]
------------------------------------
A
K
E
I
P
E
V
L
V
D
P
R
S
R
R
R
Y
V
R
G
R
F
L
G
K
G
G
F
A
K
C
F
E
I
S
D
A
D
T
K
E
V
F
A
G
K
I
V
P
K
S
L
L
L
K
P
H
Q
R
E
K
M
S
M
E
I
S
I
H
R
S
L
A
H
Q
H
V
V
G
F
H
G
F
F
E
D
N
D
F
V
F
V
V
L
E
L
C
R
R
R
S
L
L
E
L
H
K
R
R
K
A
L
T
E
P
E
A
R
Y
Y
L
R
Q
I
V
L
G
C
Q
Y
L
H
R
N
R
V
I
H
R
D
L
K
L
G
N
L
F
L
N
E
D
L
E
V
K
I
G
D
F
G
L
A
T
K
V
E
Y
D
G
E
R
K
K
V
L
C
G
T
P
N
Y
I
A
P
E
V
L
S
K
K
G
H
S
F
E
V
D
V
W
S
I
G
C
I
M
Y
T
L
L
V
G
K
P
P
F
E
T
S
C
L
K
E
T
Y
L
R
I
K
K
N
E
Y
S
I
P
K
H
I
N
P
V
A
A
S
L
I
Q
K
M
L
Q
T
D
P
T
A
R
P
T
I
N
E
L
L
N
D
E
F
F
T
S
G
Y
I
P
A
R
L
P
I
T
C
L
T
I
P
P
R
F
S
I
A
P
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
94.30
100%
-131
- C1 -
-
2YAC
2
PLK1_HUMAN
A:
[5-294]
--------------------------------------
E
I
P
E
V
L
V
D
P
R
S
R
R
R
Y
V
R
G
R
F
L
G
K
G
G
F
A
K
C
F
E
I
S
D
A
D
T
K
E
V
F
A
G
K
I
V
P
K
S
L
L
L
K
P
H
Q
R
E
K
M
S
M
E
I
S
I
H
R
S
L
A
H
Q
H
V
V
G
F
H
G
F
F
E
D
N
D
F
V
F
V
V
L
E
L
C
R
R
R
S
L
L
E
L
H
K
R
R
K
A
L
T
E
P
E
A
R
Y
Y
L
R
Q
I
V
L
G
C
Q
Y
L
H
R
N
R
V
I
H
R
D
L
K
L
G
N
L
F
L
N
E
D
L
E
V
K
I
G
D
F
G
L
A
T
K
V
E
Y
D
G
E
R
K
K
T
L
C
G
T
P
N
Y
I
A
P
E
V
L
S
K
K
G
H
S
F
E
V
D
V
W
S
I
G
C
I
M
Y
T
L
L
V
G
K
P
P
F
E
T
S
C
L
K
E
T
Y
L
R
I
K
K
N
E
Y
S
I
P
K
H
I
N
P
V
A
A
S
L
I
Q
K
M
L
Q
T
D
P
T
A
R
P
T
I
N
E
L
L
N
D
E
F
F
T
S
G
Y
I
P
A
R
L
P
I
T
C
L
T
I
P
P
R
F
S
I
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
94.28
99%
-127
- C1 -
-
5TA6
1
PLK1_HUMAN
A:
[50-343]
------------------------------------
A
K
E
I
P
E
V
L
V
D
P
R
S
R
R
R
Y
V
R
G
R
F
L
G
K
G
G
F
A
K
C
F
E
I
S
D
A
D
T
K
E
V
F
A
G
K
I
V
P
K
S
L
L
L
K
P
H
Q
R
E
K
M
S
M
E
I
S
I
H
R
S
L
A
H
Q
H
V
V
G
F
H
G
F
F
E
D
N
D
F
V
F
V
V
L
E
L
C
R
R
R
S
L
L
E
L
H
K
R
R
K
A
L
T
E
P
E
A
R
Y
Y
L
R
Q
I
V
L
G
C
Q
Y
L
H
R
N
R
V
I
H
R
D
L
K
L
G
N
L
F
L
N
E
D
L
E
V
K
I
G
D
F
G
L
A
T
K
V
E
Y
D
G
E
R
K
K
V
L
C
G
T
P
N
Y
I
A
P
E
V
L
S
K
K
G
H
S
F
E
V
D
V
W
S
I
G
C
I
M
Y
T
L
L
V
G
K
P
P
F
E
T
S
C
L
K
E
T
Y
L
R
I
K
K
N
E
Y
S
I
P
K
H
I
N
P
V
A
A
S
L
I
Q
K
M
L
Q
T
D
P
T
A
R
P
T
I
N
E
L
L
N
D
E
F
F
T
S
G
Y
I
P
A
R
L
P
I
T
C
L
T
I
P
P
R
F
S
I
A
P
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
94.08
99%
-140
- C1 -
-
3THB
-
PLK1_HUMAN
A:
[30-316]
-----------------------------------------
E
V
L
V
D
P
R
S
R
R
R
Y
V
R
G
R
F
L
G
K
G
G
F
A
K
C
F
E
I
S
D
A
D
T
K
E
V
F
A
G
K
I
V
P
K
S
L
L
L
K
P
H
Q
R
E
K
M
S
M
E
I
S
I
H
R
S
L
A
H
Q
H
V
V
G
F
H
G
F
F
E
D
N
D
F
V
F
V
V
L
E
L
C
R
R
R
S
L
L
E
L
H
K
R
R
K
A
L
T
E
P
E
A
R
Y
Y
L
R
Q
I
V
L
G
C
Q
Y
L
H
R
N
R
V
I
H
R
D
L
K
L
G
N
L
F
L
N
E
D
L
E
V
K
I
G
D
F
G
L
A
T
K
V
E
Y
D
G
E
R
K
K
V
L
C
G
T
P
N
Y
I
A
P
E
V
L
S
K
K
G
H
S
F
E
V
D
V
W
S
I
G
C
I
M
Y
T
L
L
V
G
K
P
P
F
E
T
S
C
L
K
E
T
Y
L
R
I
K
K
N
E
Y
S
I
P
K
H
I
N
P
V
A
A
S
L
I
Q
K
M
L
Q
T
D
P
T
A
R
P
T
I
N
E
L
L
N
D
E
F
F
T
S
G
Y
I
P
A
R
L
P
I
T
C
L
T
I
P
P
R
F
S
I
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
93.71
100%
-131
- C1 -
-
4A4L
2
PLK1_HUMAN
A:
[5-294]
--------------------------------------
E
I
P
E
V
L
V
D
P
R
S
R
R
R
Y
V
R
G
R
F
L
G
K
G
G
F
A
K
C
F
E
I
S
D
A
D
T
K
E
V
F
A
G
K
I
V
P
K
S
L
L
L
K
P
H
Q
R
E
K
M
S
M
E
I
S
I
H
R
S
L
A
H
Q
H
V
V
G
F
H
G
F
F
E
D
N
D
F
V
F
V
V
L
E
L
C
R
R
R
S
L
L
E
L
H
K
R
R
K
A
L
T
E
P
E
A
R
Y
Y
L
R
Q
I
V
L
G
C
Q
Y
L
H
R
N
R
V
I
H
R
D
L
K
L
G
N
L
F
L
N
E
D
L
E
V
K
I
G
D
F
G
L
A
T
K
V
E
Y
D
G
E
R
K
K
T
L
C
G
T
P
N
Y
I
A
P
E
V
L
S
K
K
G
H
S
F
E
V
D
V
W
S
I
G
C
I
M
Y
T
L
L
V
G
K
P
P
F
E
T
S
C
L
K
E
T
Y
L
R
I
K
K
N
E
Y
S
I
P
K
H
I
N
P
V
A
A
S
L
I
Q
K
M
L
Q
T
D
P
T
A
R
P
T
I
N
E
L
L
N
D
E
F
F
T
S
G
Y
I
P
A
R
L
P
I
T
C
L
T
I
P
P
R
F
S
I
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
93.52
100%
-135
- C1 -
-
2RKU
6
PLK1_HUMAN
A:
[3-291]
--------------------------------------
E
I
P
E
V
L
V
D
P
R
S
R
R
R
Y
V
R
G
R
F
L
G
K
G
G
F
A
K
C
F
E
I
S
D
A
D
T
K
E
V
F
A
G
K
I
V
P
K
S
L
L
L
K
P
H
Q
R
E
K
M
S
M
E
I
S
I
H
R
S
L
A
H
Q
H
V
V
G
F
H
G
F
F
E
D
N
D
F
V
F
V
V
L
E
L
C
R
R
R
S
L
L
E
L
H
K
R
R
K
A
L
T
E
P
E
A
R
Y
Y
L
R
Q
I
V
L
G
C
Q
Y
L
H
R
N
R
V
I
H
R
D
L
K
L
G
N
L
F
L
N
E
D
L
E
V
K
I
G
D
F
G
L
A
T
K
V
E
Y
D
G
E
R
K
K
V
L
C
G
T
P
N
Y
I
A
P
E
V
L
S
K
K
G
H
S
F
E
V
D
V
W
S
I
G
C
I
M
Y
T
L
L
V
G
K
P
P
F
E
T
S
C
L
K
E
T
Y
L
R
I
K
K
N
E
Y
S
I
P
K
H
I
N
P
V
A
A
S
L
I
Q
K
M
L
Q
T
D
P
T
A
R
P
T
I
N
E
L
L
N
D
E
F
F
T
S
G
Y
I
P
A
R
L
P
I
T
C
L
T
I
P
P
R
F
S
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
93.28
100%
-127
- C1 -
-
4A4O
2
PLK1_HUMAN
A:
[5-294]
--------------------------------------
E
I
P
E
V
L
V
D
P
R
S
R
R
R
Y
V
R
G
R
F
L
G
K
G
G
F
A
K
C
F
E
I
S
D
A
D
T
K
E
V
F
A
G
K
I
V
P
K
S
L
L
L
K
P
H
Q
R
E
K
M
S
M
E
I
S
I
H
R
S
L
A
H
Q
H
V
V
G
F
H
G
F
F
E
D
N
D
F
V
F
V
V
L
E
L
C
R
R
R
S
L
L
E
L
H
K
R
R
K
A
L
T
E
P
E
A
R
Y
Y
L
R
Q
I
V
L
G
C
Q
Y
L
H
R
N
R
V
I
H
R
D
L
K
L
G
N
L
F
L
N
E
D
L
E
V
K
I
G
D
F
G
L
A
T
K
V
E
Y
D
G
E
R
K
K
T
L
C
G
T
P
N
Y
I
A
P
E
V
L
S
K
K
G
H
S
F
E
V
D
V
W
S
I
G
C
I
M
Y
T
L
L
V
G
K
P
P
F
E
T
S
C
L
K
E
T
Y
L
R
I
K
K
N
E
Y
S
I
P
K
H
I
N
P
V
A
A
S
L
I
Q
K
M
L
Q
T
D
P
T
A
R
P
T
I
N
E
L
L
N
D
E
F
F
T
S
G
Y
I
P
A
R
L
P
I
T
C
L
T
I
P
P
R
F
S
I
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
91.92
99%
-131
- C1 -
-
2V5Q
-
PLK1_HUMAN
A:
[39-323]
--------------------------------------
E
I
P
E
V
L
V
D
P
R
S
R
R
R
Y
V
R
G
R
F
L
G
K
G
G
F
A
K
C
F
E
I
S
D
A
D
T
K
E
V
F
A
G
K
I
V
P
K
S
L
L
L
K
P
H
Q
R
E
K
M
S
M
E
I
S
I
H
R
S
L
A
H
Q
H
V
V
G
F
H
G
F
F
E
D
N
D
F
V
F
V
V
L
E
L
C
R
R
R
S
L
L
E
L
H
K
R
R
K
A
L
T
E
P
E
A
R
Y
Y
L
R
Q
I
V
L
G
C
Q
Y
L
H
R
N
R
V
I
H
R
D
L
K
L
G
N
L
F
L
N
E
D
L
E
V
K
I
G
D
F
G
L
A
T
K
V
E
Y
D
G
E
R
K
K
T
L
C
G
T
P
N
Y
I
A
P
E
V
L
S
K
K
G
H
S
F
E
V
D
V
W
S
I
G
C
I
M
Y
T
L
L
V
G
K
P
P
F
E
T
S
C
L
K
E
T
Y
L
R
I
K
K
N
E
Y
S
I
P
K
H
I
N
P
V
A
A
S
L
I
Q
K
M
L
Q
T
D
P
T
A
R
P
T
I
N
E
L
L
N
D
E
F
F
T
S
G
Y
I
P
A
R
L
P
I
T
C
L
T
I
P
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
84.72
77%
-119
- C1 -
-
3D5U
-
?
A:
[23-310]
------------------------------------
L
K
E
I
P
D
V
L
V
D
P
R
T
M
K
R
Y
M
R
G
R
F
L
G
K
G
G
F
A
K
C
Y
E
I
T
D
M
D
T
K
E
V
F
A
G
K
V
V
P
K
S
M
L
L
K
P
H
Q
K
E
K
M
S
T
E
I
A
I
H
K
S
L
D
N
P
H
V
V
G
F
H
G
F
F
E
D
D
D
F
V
Y
V
V
L
E
I
C
R
R
R
S
L
L
E
L
H
K
R
R
K
A
V
T
E
P
E
A
R
Y
F
M
R
Q
T
I
Q
G
V
Q
Y
L
H
N
N
R
V
I
H
R
D
L
K
L
G
N
L
F
L
N
D
D
M
D
V
K
I
G
D
F
G
L
A
T
K
I
E
F
D
G
E
R
K
K
T
L
C
G
T
P
N
Y
I
A
P
E
V
L
C
K
K
G
H
S
F
E
V
D
I
W
S
L
G
C
I
L
Y
T
L
L
V
G
K
P
P
F
E
T
S
C
L
K
E
T
Y
I
R
I
K
K
N
E
Y
S
V
P
R
H
I
N
P
V
A
S
A
L
I
R
R
M
L
H
A
D
P
T
L
R
P
S
V
A
E
L
L
T
D
E
F
F
T
S
G
Y
A
P
M
R
L
P
T
S
C
L
T
V
P
P
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
84.13
76%
-121
- C1 -
-
3D5W
1
?
A:
[29-315]
-------------------------------------
K
E
I
P
D
V
L
V
D
P
R
T
M
K
R
Y
M
R
G
R
F
L
G
K
G
G
F
A
K
C
Y
E
I
T
D
M
D
T
K
E
V
F
A
G
K
V
V
P
K
S
M
L
--
P
H
Q
K
E
K
M
S
T
E
I
A
I
H
K
S
L
D
N
P
H
V
V
G
F
H
G
F
F
E
D
D
D
F
V
Y
V
V
L
E
I
C
R
R
R
S
L
L
E
L
H
K
R
R
K
A
V
T
E
P
E
A
R
Y
F
M
R
Q
T
I
Q
G
V
Q
Y
L
H
N
N
R
V
I
H
R
D
L
K
L
G
N
L
F
L
N
D
D
M
D
V
K
I
G
D
F
G
L
A
T
K
I
E
F
D
G
E
R
K
K
T
L
C
G
T
P
N
Y
I
A
P
E
V
L
C
K
K
G
H
S
F
E
V
D
I
W
S
L
G
C
I
L
Y
T
L
L
V
G
K
P
P
F
E
T
S
C
L
K
E
T
Y
I
R
I
K
K
N
E
Y
S
V
P
R
H
I
N
P
V
A
S
A
L
I
R
R
M
L
H
A
D
P
T
L
R
P
S
V
A
E
L
L
T
D
E
F
F
T
S
G
Y
A
P
M
R
L
P
T
S
C
L
T
V
P
P
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
81.82
76%
-136
- C1 -
-
3DB8
1
?
A:
[29-315]
-------------------------------------
K
E
I
P
D
V
L
V
D
P
R
T
M
K
R
Y
M
R
G
R
F
L
G
K
G
G
F
A
K
C
Y
E
I
T
D
M
D
T
K
E
V
F
A
G
K
V
V
P
K
S
M
L
L
K
P
H
Q
K
E
K
M
S
T
E
I
A
I
H
K
S
L
D
N
P
H
V
V
G
F
H
G
F
F
E
D
D
D
F
V
Y
V
V
L
E
I
C
R
R
R
S
L
L
E
L
H
K
R
R
K
A
V
T
E
P
E
A
R
Y
F
M
R
Q
T
I
Q
G
V
Q
Y
L
H
N
N
R
V
I
H
R
D
L
K
L
G
N
L
F
L
N
D
D
M
D
V
K
I
G
D
F
G
L
A
T
K
I
--------------------------
H
S
F
E
V
D
I
W
S
L
G
C
I
L
Y
T
L
L
V
G
K
P
P
F
E
T
S
C
L
K
E
T
Y
I
R
I
K
K
N
E
Y
S
V
P
R
H
I
N
P
V
A
S
A
L
I
R
R
M
L
H
A
D
P
T
L
R
P
S
V
A
E
L
L
T
D
E
F
F
T
S
G
Y
A
P
M
R
L
P
T
S
C
L
T
V
P
P
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
81.74
76%
-139
- C1 -
-
3D5V
-
?
A:
[25-312]
--------------------------------------
E
I
P
D
V
L
V
D
P
R
T
M
K
R
Y
M
R
G
R
F
L
G
K
G
G
F
A
K
C
Y
E
I
T
D
M
D
T
K
E
V
F
A
G
K
V
V
P
K
S
M
L
---
H
Q
K
E
K
M
S
T
E
I
A
I
H
K
S
L
D
N
P
H
V
V
G
F
H
G
F
F
E
D
D
D
F
V
Y
V
V
L
E
I
C
R
R
R
S
L
L
E
L
H
K
R
R
K
A
V
T
E
P
E
A
R
Y
F
M
R
Q
T
I
Q
G
V
Q
Y
L
H
N
N
R
V
I
H
R
D
L
K
L
G
N
L
F
L
N
D
D
M
D
V
K
I
G
D
F
G
L
A
T
K
I
E
-------------------------
H
S
F
E
V
D
I
W
S
L
G
C
I
L
Y
T
L
L
V
G
K
P
P
F
E
T
S
C
L
K
E
T
Y
I
R
I
K
K
N
E
Y
S
V
P
R
H
I
N
P
V
A
S
A
L
I
R
R
M
L
H
A
D
P
T
L
R
P
S
V
A
E
L
L
T
D
E
F
F
T
S
G
Y
A
P
M
R
L
P
T
S
C
L
T
V
P
P
R
F
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
81.49
76%
-138
- C1 -
-
3DBD
1
?
A:
[29-315]
-------------------------------------
K
E
I
P
D
V
L
V
D
P
R
T
M
K
R
Y
M
R
G
R
F
L
G
K
G
G
F
A
K
C
Y
E
I
T
D
M
D
T
K
E
V
F
A
G
K
V
V
P
K
S
M
L
L
K
P
H
Q
K
E
K
M
S
T
E
I
A
I
H
K
S
L
D
N
P
H
V
V
G
F
H
G
F
F
E
D
D
D
F
V
Y
V
V
L
E
I
C
R
R
R
S
L
L
E
L
H
K
R
R
K
A
V
T
E
P
E
A
R
Y
F
M
R
Q
T
I
Q
G
V
Q
Y
L
H
N
N
R
V
I
H
R
D
L
K
L
G
N
L
F
L
N
D
D
M
D
V
K
I
G
D
F
G
L
A
T
K
I
--------------------------
H
S
F
E
V
D
I
W
S
L
G
C
I
L
Y
T
L
L
V
G
K
P
P
F
E
T
S
C
L
K
E
T
Y
I
R
I
K
K
N
E
Y
S
V
P
R
H
I
N
P
V
A
S
A
L
I
R
R
M
L
H
A
D
P
T
L
R
P
S
V
A
E
L
L
T
D
E
F
F
T
S
G
Y
A
P
M
R
L
P
T
S
C
L
T
V
P
P
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
80.13
76%
-133
- C1 -
-
3DBC
1
?
A:
[29-315]
-------------------------------------
K
E
I
P
D
V
L
V
D
P
R
T
M
K
R
Y
M
R
G
R
F
L
G
K
G
G
F
A
K
C
Y
E
I
T
D
M
D
T
K
E
V
F
A
G
K
V
V
P
K
S
M
L
L
K
P
H
Q
K
E
K
M
S
T
E
I
A
I
H
K
S
L
D
N
P
H
V
V
G
F
H
G
F
F
E
D
D
D
F
V
Y
V
V
L
E
I
C
R
R
R
S
L
L
E
L
H
K
R
R
K
A
V
T
E
P
E
A
R
Y
F
M
R
Q
T
I
Q
G
V
Q
Y
L
H
N
N
R
V
I
H
R
D
L
K
L
G
N
L
F
L
N
D
D
M
D
V
K
I
G
D
F
G
L
A
T
K
I
--------------------------
H
S
F
E
V
D
I
W
S
L
G
C
I
L
Y
T
L
L
V
G
K
P
P
F
E
T
S
C
L
K
E
T
Y
I
R
I
K
K
N
E
Y
S
V
P
R
H
I
N
P
V
A
S
A
L
I
R
R
M
L
H
A
D
P
T
L
R
P
S
V
A
E
L
L
T
D
E
F
F
T
S
G
Y
A
P
M
R
L
P
T
S
C
L
T
V
P
P
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
76.60
52%
-126
- C1 -
-
4I5P
1
PLK2_HUMAN
A:
[19-298]
-----------------------------------------
R
I
I
V
D
P
T
T
G
K
R
Y
S
R
G
K
T
L
G
K
G
G
F
A
K
C
Y
E
M
T
D
L
T
N
N
K
V
Y
A
A
K
I
I
P
H
S
R
V
S
K
P
H
Q
R
E
K
I
D
K
E
I
E
L
H
R
I
L
H
H
K
H
V
V
Q
F
Y
H
Y
F
E
D
K
E
N
I
Y
I
L
L
E
Y
C
S
R
R
S
M
A
H
I
L
K
A
R
K
V
L
T
E
P
E
V
R
Y
Y
L
R
Q
I
V
S
G
L
K
Y
L
H
E
Q
E
I
L
H
R
D
L
K
L
G
N
F
F
I
N
E
S
M
E
L
K
V
G
D
F
G
L
A
A
R
L
E
P
L
E
H
R
R
R
T
I
C
G
T
P
N
Y
L
S
P
E
V
L
N
K
Q
G
H
G
A
E
S
D
I
W
A
L
G
C
V
M
Y
T
M
L
L
G
R
P
P
F
E
T
T
N
L
K
E
T
Y
R
S
I
R
E
A
R
Y
T
M
P
S
S
L
L
A
P
A
K
H
L
I
A
S
M
L
S
K
N
P
E
D
R
P
S
L
D
D
I
I
R
H
D
F
F
T
Q
G
F
T
P
D
R
L
S
S
S
C
C
H
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
76.16
54%
-122
- C1 -
-
4B6L
1
PLK3_HUMAN
A:
[4-276]
---------------------------------------------
D
P
R
S
G
R
T
Y
L
K
G
R
L
L
G
K
G
G
F
A
R
C
Y
E
A
T
D
T
E
T
G
S
A
Y
A
V
K
V
I
P
Q
S
R
V
A
K
P
H
Q
R
E
K
I
L
N
E
I
E
L
H
R
D
L
Q
H
R
H
I
V
R
F
S
H
H
F
E
D
A
D
N
I
Y
I
F
L
E
L
C
S
R
K
S
L
A
H
I
W
K
A
R
H
T
L
L
E
P
E
V
R
Y
Y
L
R
Q
I
L
S
G
L
K
Y
L
H
Q
R
G
I
L
H
R
D
L
K
L
G
N
F
F
I
T
E
N
M
E
L
K
V
G
D
F
G
L
A
A
R
L
E
P
P
E
Q
R
K
K
T
I
C
G
T
P
N
Y
V
A
P
E
V
L
L
R
Q
G
H
G
P
E
A
D
V
W
S
L
G
C
V
M
Y
T
L
L
C
G
S
P
P
F
E
T
A
D
L
K
E
T
Y
R
C
I
K
Q
V
H
Y
T
L
P
A
S
L
S
L
P
A
R
Q
L
L
A
A
I
L
R
A
S
P
R
D
R
P
S
I
D
Q
I
L
R
H
D
F
F
T
K
G
Y
T
P
D
R
L
P
I
S
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------