@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : TNKS1_HUMAN: (2018-07-14 )
MAASRRSQHHHHHHQQQLQPAPGASAPPPPPPPPLSPGLAPGTTPASPTASGLAPFASPRHGLALPEGDGSRDPPDRPRSPDPVDGTSCCSTTSTICTVAAAPVVPAVSTSSAAGVAPNPAGSGSNNSPSSSSSPTSSSSSSPSSPGSSLAESPEAAGVSSTAPLGPGAAGPGTGVPAVSGALRELLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATADDIRALLIDAMPPEALPTCFKPQATVVSASLISPASTPSCLSAASSIDNLTGPLAELAVGGASNAGDGAAGTERKEGEVAGLDMNISQFLKSLGLEHLRDIFETEQITLDVLADMGHEELKEIGINAYGHRHKLIKGVERLLGGQQGTNPYLTFHCVNQGTILLDLAPEDKEYQSVEEEMQSTIREHRDGGNAGGIFNRYNVIRIQKVVNKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPTHKDRSCYICHRQMLFCRVTLGKSFLQFSTMKMAHAPPGHHSVIGRPSVNGLAYAEYVIYRGEQAYPEYLITYQIMKPEAPSQTATAAEQKT
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200..-.....210.......220.......230.......240--------------------------------------------------------------------------........250.......260.......270.......280.......290.......300.......310.......320.......330--------------.......340.......350.......360-----.........370.......380.......390.-......400.......410.......420......--------.430---------------------------------.........440.......450.......460.......470.......480.......---------------------490.....---------...500.......510----------------------------------.---.--..-...520.......530.......540.......550.......560.......570.......580.......590.......600.......610....-...620.......630-----.......640....--...650.......660.......670-.......680.......690.......700.......710--........720.......730.......740.......750.......760.......770.......780.......790-.-......800-------------------------.......810.......820....-...830........840.....---..850.......860-.......870.......880.......890.......900.......910.......920.......930.......940.....---..950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310......1320....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MAASRRS
Q
H
H
H
H
H
H
Q
Q
QLQPAPGASAPPPPPPPPLSPGLAPGTTPASPTASGLAPFASPRHGLALPEGDGSRDPPDRPRSPDPVDGTSCCSTTS
T
I
C
T
VAAAPVVPAVSTSSAAGVAPNPAGSGSNNSPSSSSSPTSSSSSSPSSPGSSLAESPEAAGVSSTAPLGPGAAGPGTGV
P
A
V
S
G
A
L
R
E
L
L
E
A
C
RNG
D
V
S
R
V
K
R
L
V
D
A-ANV
N
A
K
D
MAGRKSSP
L
H
F
AAGF
G
R
K
D
V
V
E
H
L
L
Q
MGA
N
---------------------------------------------------------------------------
V
H
ARDDG
G
L
I
PLHNACSF
G
H
A
E
V
V
S
L
L
L
CQGADPNARDNWNYTP
L
H
E
A
A
IKGKI
D
V
C
I
V
L
L
QHGADPNIRNTDGKSALDLADPSA
K
A
V
L
TG--------------EY
K
K
D
E
L
L
E
A
A
RSG
N
E
E
K
L
M
A
L
LTPL
N
V
-------
N
C
HASDGRKST
P
L
H
L
AAGY
N
R
V
R
I
V
Q
L
L
L
QHGA-DVHAKDKG
G
L
V
PLHNACSY
G
H
Y
E
V
T
E
L
L
L
KHGACV--------
N
A
-----------------------------------
M
D
L
WQFT
P
L
H
E
A
ASK
N
R
V
E
V
C
S
L
L
L
SHGADP
T
L
V
N
CHGKSAVDMAP
T
P
E
L
R
E
R
L
T
Y
EFK---------------------
G
H
-
S
L
L
Q
A
---------
A
R
E
A
D
L
A
K
V
K
K
T
L
A
L
E
----------------------------------
I
---
I
--NF-KQPQSH
E
T
A
L
H
C
A
V
A
SLH
P
K
R
K
Q
V
T
E
L
L
L
RKGANVNEKNKD
F
M
T
P
L
H
V
A
A
E
R
A
H
N
D
V
M
E
V
L
H
KHGAKM
N
A
L
D
T
L
G
Q
T
A
L
H
R
A
A
L
A
G
H
L
Q
T
C
R
L
L
L
SYGSD-P
S
I
I
S
L
QG
F
T
A
A
Q
M
G
N
-----
E
A
V
Q
Q
I
L
SESTPIR--TSDV
D
Y
R
L
LEASKAG
D
L
E
T
V
K
Q
L
C
SS-QNVNCRDLEGRHST
P
L
H
F
AAGY
N
R
V
S
V
V
E
Y
L
L
HHGADVH---AKDKG
G
L
V
PLHNACSY
G
H
Y
E
V
A
E
L
L
V
RHGASV
N
V
A
D
L
WKFT
P
L
H
E
A
A
AK
G
K
Y
E
I
C
K
L
L
L
KHGADPTKKNRDGNT
P
L
D
L
VKE-G-DT
D
I
Q
D
L
L
R-------------------------G
D
A
A
L
L
D
A
A
K
K
G
C
L
A
R
V
Q
K
LCTPE-NINCR-DTQGRNST
P
L
H
L
AAGY---N
N
L
E
V
A
E
Y
L
L
EHGAD-VNAQDKG
G
L
I
PLHNAASYG
H
V
D
I
A
A
L
L
I
KYNTCVNATDKWAF
T
P
L
H
E
A
A
QK
G
R
T
Q
L
C
A
L
L
L
AHGADPTMKNQEGQTPLDLA
T
A
D
D
---
I
R
A
L
L
IDAM
P
P
E
ALPTCFKPQ
A
T
V
V
S
A
SLISPAST
P
S
C
L
S
A
A
S
S
I
D
N
LT
G
P
L
A
E
L
AVGGASNAGDGAAGTERKEGEVAGLDM
N
I
S
Q
F
L
K
S
L
G
L
E
H
L
R
D
I
F
E
T
E
Q
I
T
L
D
V
L
A
DM
G
H
E
E
L
K
E
IGINAYG
H
R
H
K
L
I
K
G
V
E
R
L
LGGQQGTN
P
Y
L
T
F
H
C
VNQ
G
T
I
L
L
DLAPE
D
K
E
Y
Q
S
V
E
E
E
M
Q
S
T
I
R
E
HRDGGNAGGIFNRY
N
V
I
R
I
Q
K
V
V
N
K
K
L
R
E
R
F
C
H
R
Q
K
EVSEENHNHHN
E
R
M
L
FHG
S
P
F
I
N
A
I
I
HKGF
D
E
R
H
A
Y
IGGMFG
A
G
I
Y
F
AENSSKSN
Q
Y
V
Y
G
IGGGTGCPTHKDR
S
C
Y
I
C
HR
Q
M
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
T
M
K
MAHAPPGHHSVIGRPSVN
G
L
A
Y
A
E
Y
V
I
YRGEQAYP
E
Y
L
I
T
Y
Q
I
MKPEAPSQTATAAEQKT
1
PsiBlast_PDB
69.56
98%
-77
- C2 -
-
5JHQ
-
TNKS1_HUMAN
A:
[14-475]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
A
L
R
E
L
L
E
A
C
R
N
G
D
V
S
R
V
K
R
L
V
D
A
-
A
N
V
N
A
K
D
M
A
G
R
K
S
S
P
L
H
F
A
A
G
F
G
R
K
D
V
V
E
H
L
L
Q
M
G
A
N
---------------------------------------------------------------------------
V
H
A
R
D
D
G
G
L
I
P
L
H
N
A
C
S
F
G
H
A
E
V
V
S
L
L
L
C
Q
G
A
D
P
N
A
R
D
N
W
N
Y
T
P
L
H
E
A
A
I
K
G
K
I
D
V
C
I
V
L
L
Q
H
G
A
D
P
N
I
R
N
T
D
G
K
S
A
L
D
L
A
D
P
S
A
K
A
V
L
T
G
--------------
E
Y
K
K
D
E
L
L
E
A
A
R
S
G
N
E
E
K
L
M
A
L
L
T
P
L
N
V
-------
N
C
H
A
S
D
G
R
K
S
T
P
L
H
L
A
A
G
Y
N
R
V
R
I
V
Q
L
L
L
Q
H
G
A
-
D
V
H
A
K
D
K
G
G
L
V
P
L
H
N
A
C
S
Y
G
H
Y
E
V
T
E
L
L
L
K
H
G
A
C
V
--------
N
A
-----------------------------------
M
D
L
W
Q
F
T
P
L
H
E
A
A
S
K
N
R
V
E
V
C
S
L
L
L
S
H
G
A
D
P
T
L
V
N
C
H
G
K
S
A
V
D
M
A
P
T
P
E
L
R
E
R
L
T
Y
E
F
K
---------------------
G
H
-
S
L
L
Q
A
---------
A
R
E
A
D
L
A
K
V
K
K
T
L
A
L
E
----------------------------------
I
---
I
--
N
F
-
K
Q
P
Q
S
H
E
T
A
L
H
C
A
V
A
S
L
H
P
K
R
K
Q
V
T
E
L
L
L
R
K
G
A
N
V
N
E
K
N
K
D
F
M
T
P
L
H
V
A
A
E
R
A
H
N
D
V
M
E
V
L
H
K
H
G
A
K
M
N
A
L
D
T
L
G
Q
T
A
L
H
R
A
A
L
A
G
H
L
Q
T
C
R
L
L
L
S
Y
G
S
D
-
P
S
I
I
S
L
Q
G
F
T
A
A
Q
M
G
N
-----
E
A
V
Q
Q
I
L
S
E
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
68.63
100%
-75
- C2 -
-
5JHQ
-
TNKS1_HUMAN
D:
[15-461]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
R
E
L
L
E
A
C
R
N
G
D
V
S
R
V
K
R
L
V
D
A
-
A
N
V
N
A
K
D
M
A
G
R
K
S
S
P
L
H
F
A
A
G
F
G
R
K
D
V
V
E
H
L
L
Q
M
G
A
N
---------------------------------------------------------------------------
V
H
A
R
D
D
G
G
L
I
P
L
H
N
A
C
S
F
G
H
A
E
V
V
S
L
L
L
C
Q
G
A
D
P
N
A
R
D
N
W
N
Y
T
P
L
H
E
A
A
I
K
G
K
I
D
V
C
I
V
L
L
Q
H
G
A
D
P
N
I
R
N
T
D
G
K
S
A
L
D
L
A
D
P
S
A
K
A
V
L
T
G
--------------
E
Y
K
K
D
E
L
L
E
A
A
R
S
G
N
E
E
K
L
M
A
L
L
T
P
L
N
V
-------
N
C
H
A
S
D
G
R
K
S
T
P
L
H
L
A
A
G
Y
N
R
V
R
I
V
Q
L
L
L
Q
H
G
A
-
D
V
H
A
K
D
K
G
G
L
V
P
L
H
N
A
C
S
Y
G
H
Y
E
V
T
E
L
L
L
K
H
G
A
C
V
--------
N
A
-----------------------------------
M
D
L
W
Q
F
T
P
L
H
E
A
A
S
K
N
R
V
E
V
C
S
L
L
L
S
H
G
A
D
P
T
L
V
N
C
H
G
K
S
A
V
D
M
A
P
T
P
E
L
R
E
R
L
T
Y
E
F
K
---------------------
G
H
-
S
L
L
Q
A
---------
A
R
E
A
D
L
A
K
V
K
K
T
L
A
L
E
----------------------------------
I
---
I
--
N
F
-
K
Q
P
Q
S
H
E
T
A
L
H
C
A
V
A
S
L
H
P
K
R
K
Q
V
T
E
L
L
L
R
K
G
A
N
V
N
E
K
N
K
D
F
M
T
P
L
H
V
A
A
E
R
A
H
N
D
V
M
E
V
L
H
K
H
G
A
K
M
N
A
L
D
T
L
G
Q
T
A
L
H
R
A
A
L
A
G
H
L
Q
T
C
R
L
L
L
S
Y
G
S
D
-
P
S
I
I
S
L
Q
G
F
T
A
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
58.40
40%
-97
- C2 -
-
5LEB
-
?
A:
[15-473]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
K
L
L
E
A
A
R
A
G
Q
D
D
E
V
R
I
L
L
A
N
G
A
D
---------------------------------------------------------------------------
V
N
T
A
D
E
T
G
F
T
P
L
H
L
A
A
W
E
G
H
L
G
I
V
E
V
L
L
K
N
G
A
D
V
N
A
N
D
E
R
G
H
T
P
L
H
L
A
A
Y
T
G
H
L
E
I
V
E
V
L
L
K
N
G
A
G
V
N
A
T
---------------------------------------------------------------------------
D
V
I
G
T
A
P
L
H
L
A
A
M
W
G
H
L
E
I
V
E
V
L
L
K
N
G
A
-
D
V
F
A
Q
D
K
F
G
K
T
P
F
D
L
A
R
D
N
G
N
E
W
I
A
K
L
L
L
A
A
--------------------------------------------------------
A
L
L
E
A
A
R
Q
G
Q
R
D
R
V
E
K
L
M
A
N
G
A
D
V
N
T
A
D
E
-----------------------------------------------------------------------------------------------------------------------------
T
G
F
T
P
L
H
L
A
A
W
E
G
---
H
L
G
I
V
E
V
L
L
K
N
G
A
D
V
N
A
N
D
E
R
G
H
T
P
L
H
L
A
A
Y
T
G
H
L
E
I
V
E
V
L
L
K
N
G
A
G
V
N
A
T
D
V
I
G
T
A
P
L
H
L
A
A
M
W
G
H
L
E
I
V
E
V
L
L
K
N
G
A
D
-
V
F
A
Q
D
--------------------------------------------------------------------
K
F
G
K
T
P
F
D
L
A
R
D
N
G
N
E
W
I
A
K
L
L
L
A
A
A
----------------
L
L
E
A
A
R
Q
G
Q
R
D
R
V
E
K
L
M
A
N
G
A
D
V
N
T
A
D
E
T
G
F
T
P
L
H
L
A
A
W
E
G
H
L
G
I
V
E
V
L
L
K
N
G
A
D
V
N
A
N
D
E
R
-----------------------------------------------------------------------------------
G
H
T
P
L
H
L
A
A
Y
T
---
G
H
L
E
I
V
E
V
L
L
K
N
G
A
G
-
V
N
A
T
D
V
I
G
T
A
P
L
H
L
A
A
M
W
G
H
L
E
I
V
E
V
L
L
K
N
G
A
D
V
N
A
Q
D
K
F
G
K
T
P
F
D
L
A
I
D
N
G
N
E
D
I
A
E
V
L
Q
K
A
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
56.38
35%
-78
- C2 -
-
5Y4F
-
ANK2_HUMAN
A:
[2-390]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
T
P
I
H
V
A
A
F
M
G
H
L
N
I
V
L
L
L
L
Q
N
G
A
-
S
P
D
V
T
N
I
R
G
E
T
A
L
H
M
A
A
R
A
G
Q
V
E
V
V
R
C
L
L
R
N
G
A
L
V
--------
D
A
-----------------------------------
R
A
R
E
E
Q
T
P
L
H
I
A
S
R
L
G
K
T
E
I
V
Q
L
L
L
Q
H
M
A
H
P
D
A
A
T
T
-----------------------------------------------------------------------------------------------------------------------------
N
G
Y
T
P
L
H
I
S
A
R
E
G
---
Q
V
D
V
A
S
V
L
L
E
A
G
A
A
H
S
L
A
T
K
K
G
F
T
P
L
H
V
A
A
K
Y
G
S
L
D
V
A
K
L
L
L
Q
R
R
A
A
A
D
S
A
G
K
N
G
L
T
P
L
H
V
A
A
H
Y
D
N
Q
K
V
A
L
L
L
L
E
K
G
A
S
-
P
H
A
T
--------------------------------------------------------------------
A
K
N
G
Y
T
P
L
H
I
A
A
K
K
N
Q
M
Q
I
A
S
T
L
L
N
Y
G
A
E
T
N
---
I
V
T
K
Q
G
V
T
P
L
H
L
A
S
Q
E
G
H
T
D
M
V
T
L
L
L
D
K
G
A
N
I
H
M
S
T
K
S
G
L
T
S
L
H
L
A
A
Q
E
D
K
V
N
V
A
D
I
L
T
K
H
G
A
D
Q
D
A
H
T
K
-----------------------------------------------------------------------------------
L
G
Y
T
P
L
I
V
A
C
H
Y
---
G
N
V
K
M
V
N
F
L
L
K
Q
G
A
N
-
V
N
A
K
T
K
N
G
Y
T
P
L
H
Q
A
A
Q
Q
G
H
T
H
I
I
N
V
L
L
Q
H
G
A
K
P
N
A
T
T
A
N
G
N
T
A
L
A
I
A
K
R
L
G
Y
I
S
V
V
D
T
L
K
V
V
T
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
55.74
32%
-17
- C2 -
-
5Y4D
-
ANK2_HUMAN
A:
[70-711]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
A
S
F
L
R
A
A
R
A
G
N
L
D
K
V
V
E
Y
L
K
G
G
I
D
---------------------------------------------------------------------------
I
N
T
C
N
Q
N
G
L
N
A
L
H
L
A
A
K
E
G
H
V
G
L
V
Q
E
L
L
G
R
G
S
S
V
D
S
A
T
K
K
G
N
T
A
L
H
I
A
S
L
A
G
Q
A
E
V
V
K
V
L
V
K
E
G
A
N
I
N
A
Q
S
Q
N
G
F
T
P
L
Y
M
A
A
Q
E
----------------------------------
N
H
I
D
V
V
K
Y
L
L
E
-
N
G
A
-------
N
Q
S
T
A
T
E
D
G
F
T
P
L
A
V
A
L
Q
Q
G
H
N
Q
A
V
A
I
L
L
E
N
D
---------
V
R
L
P
A
L
H
I
A
A
R
K
D
D
T
K
S
A
A
L
L
L
Q
N
D
H
N
A
DVQSKMMV
N
R
-----------------------------------
T
T
E
S
G
F
T
P
L
H
I
A
A
H
Y
G
N
V
N
V
A
T
L
L
L
N
R
G
A
A
V
D
F
T
A
R
N
G
I
T
P
L
H
V
A
S
K
R
G
N
T
N
----------------------------------------------------
M
V
K
L
L
L
D
R
G
----------------------------------
G
---
Q
--
I
D
-
A
K
T
R
D
G
L
T
P
L
H
C
A
A
R
S
G
---
H
D
Q
V
V
E
L
L
L
E
R
G
A
P
L
L
A
R
T
K
N
G
L
S
P
L
H
M
A
A
Q
G
D
H
V
E
C
V
K
H
L
L
Q
H
K
A
P
V
D
D
V
T
L
D
Y
L
T
A
L
H
V
A
A
H
C
G
H
Y
R
V
T
K
L
L
L
D
K
R
A
N
-
P
N
A
R
A
L
N
G
---------------------------------
F
T
P
L
H
I
A
C
K
K
N
R
I
K
V
M
E
L
L
V
K
Y
-
G
-
A
S
I
Q
A
I
T
E
S
G
L
T
P
I
H
V
A
A
F
M
G
H
L
N
I
V
L
L
L
L
Q
N
G
A
S
P
D
---
V
T
N
I
R
G
E
T
A
L
H
M
A
A
R
A
G
Q
V
E
V
V
R
C
L
L
R
N
G
A
L
V
D
A
R
A
R
E
E
Q
T
P
L
H
I
A
S
R
L
G
K
T
E
I
V
Q
L
L
L
Q
H
M
A
H
P
D
A
A
T
T
N
G
Y
T
P
L
H
I
-----------------------------------------------
S
A
R
E
G
Q
V
D
V
A
S
V
L
L
E
A
G
A
A
H
S
L
A
---
T
K
K
G
F
T
P
L
H
V
A
A
K
Y
---
G
S
L
D
V
A
K
L
L
L
Q
R
R
A
A
-
A
D
S
A
G
K
N
G
L
T
P
L
H
V
A
A
H
Y
D
N
Q
K
V
A
L
L
L
L
E
K
G
A
S
P
H
A
T
A
K
N
G
Y
T
P
L
H
I
A
A
K
K
N
Q
M
Q
I
A
S
T
L
L
N
Y
G
A
E
T
N
I
V
T
K
Q
G
V
T
P
L
H
L
A
S
Q
E
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
53.79
99%
-
- C2 -
-
3UTM
-
TNKS1_MOUSE
A:
[316-635]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
S
A
K
A
V
L
T
G
--------------
E
Y
K
K
D
E
L
L
E
A
A
R
S
G
N
E
E
K
L
M
A
L
L
T
P
L
N
V
-------
N
C
H
A
S
D
G
R
K
S
T
P
L
H
L
A
A
G
Y
N
R
V
R
I
V
Q
L
L
L
Q
H
G
A
-
D
V
H
A
K
D
K
G
G
L
V
P
L
H
N
A
C
S
Y
G
H
Y
E
V
T
E
L
L
L
K
H
G
A
C
V
--------
N
A
-----------------------------------
M
D
L
W
Q
F
T
P
L
H
E
A
A
S
K
N
R
V
E
V
C
S
L
L
L
S
H
G
A
D
P
T
L
V
N
C
H
G
K
S
A
V
D
M
A
P
T
P
E
L
R
E
R
L
T
Y
E
F
K
---------------------
G
H
-
S
L
L
Q
A
---------
A
R
E
A
D
L
A
K
V
K
K
T
L
A
L
E
----------------------------------
I
---
I
--
N
F
-
K
Q
P
Q
S
H
E
T
A
L
H
C
A
V
A
S
L
H
P
K
R
K
Q
V
A
E
L
L
L
R
K
G
A
N
V
N
E
K
N
K
D
F
M
T
P
L
H
V
A
A
E
R
A
H
N
D
V
M
E
V
L
H
K
H
G
A
K
M
N
A
L
D
S
L
G
Q
T
A
L
H
R
A
A
L
A
G
H
L
Q
T
C
R
L
L
L
S
Y
G
S
D
-
P
S
I
I
S
L
Q
G
F
T
A
A
Q
M
G
N
-----
E
A
V
Q
Q
I
L
S
E
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
52.65
99%
-
- C2 -
-
5HKP
-
TNKS1_MOUSE
A:
[322-634]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
T
G
--------------
E
Y
K
K
D
E
L
L
E
A
A
R
S
G
N
E
E
K
L
M
A
L
L
T
P
L
N
V
-------
N
C
H
A
S
D
G
R
K
S
T
P
L
H
L
A
A
G
Y
N
R
V
R
I
V
Q
L
L
L
Q
H
G
A
-
D
V
H
A
K
D
K
G
G
L
V
P
L
H
N
A
C
S
Y
G
H
Y
E
V
T
E
L
L
L
K
H
G
A
C
V
--------
N
A
-----------------------------------
M
D
L
W
Q
F
T
P
L
H
E
A
A
S
K
N
R
V
E
V
C
S
L
L
L
S
H
G
A
D
P
T
L
V
N
C
H
G
K
S
A
V
D
M
A
P
T
P
E
L
R
E
R
L
T
Y
E
F
K
---------------------
G
H
-
S
L
L
Q
A
---------
A
R
E
A
D
L
A
K
V
K
K
T
L
A
L
E
----------------------------------
I
---
I
--
N
F
-
K
Q
P
Q
S
H
E
T
A
L
H
C
A
V
A
S
L
H
P
K
R
K
Q
V
A
E
L
L
L
R
K
G
A
N
V
N
E
K
N
K
D
F
M
T
P
L
H
V
A
A
E
R
A
H
N
D
V
M
E
V
L
H
K
H
G
A
K
M
N
A
L
D
S
L
G
Q
T
A
L
H
R
A
A
L
A
G
H
L
Q
T
C
R
L
L
L
S
Y
G
S
D
-
P
S
I
I
S
L
Q
G
F
T
A
A
Q
M
G
N
-----
E
A
V
Q
Q
I
L
S
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
51.84
26%
21
- C2 -
-
5VKQ
-
?
D:
[128-1199]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
T
P
L
M
Y
A
T
K
D
N
K
T
A
I
M
D
R
M
I
E
L
G
A
D
V
G
A
R
N
N
--
D
N
Y
N
V
L
H
I
A
A
M
Y
S
R
E
D
V
V
K
L
L
L
T
K
R
G
V
DPFSTGGSRSQTAVHLVSSRQTGTATNILRALLAAAGKDIRLKADGRGKIPLLLAVESGNQSMCRELLAAQTAEQ
L
K
A
T
T
A
N
G
D
T
A
L
H
L
A
A
R
R
R
D
V
D
M
V
R
I
L
V
D
Y
G
T
N
V
D
T
Q
N
G
E
G
Q
T
P
L
H
I
A
A
A
E
G
D
E
A
L
L
K
Y
F
Y
G
V
R
A
S
A
S
I
A
D
N
Q
D
R
T
P
M
H
L
A
A
E
N
G
H
A
H
V
I
E
ILADKFKASIFERT
K
D
G
S
T
L
M
H
I
A
S
L
N
G
H
A
E
C
A
T
M
L
F
K
-
K
G
V
-------
Y
L
H
M
P
N
K
D
G
A
R
S
I
H
T
A
A
A
Y
G
H
T
G
I
I
N
T
L
L
Q
K
G
E
-
K
V
D
V
T
T
N
D
N
Y
T
A
L
H
I
A
V
E
S
A
K
P
A
V
V
E
T
L
L
G
F
G
A
D
V
--------
H
V
RGGKLRETPLHIAARVKDGDRCALMLLKSGASPNL
T
T
D
D
C
L
T
P
V
H
V
A
A
R
H
G
N
L
A
T
L
M
Q
L
L
E
D
E
G
D
P
L
Y
K
S
N
T
G
E
T
P
L
H
M
A
C
R
A
C
H
P
D
I
V
R
H
L
I
E
TVKEKHGPDKATTYINSVNED
G
A
T
A
L
H
Y
T
CQITKEEVK
I
P
E
S
D
K
Q
I
V
R
M
L
L
E
N
G
ADVTLQTKTALETAFHYCAVAGNNDVLMEMISHM
N
PTD
I
QK
A
M
N
R
Q
S
S
V
G
W
T
P
L
L
I
A
C
H
R
G
---
H
M
E
L
V
N
N
L
L
A
N
H
A
R
V
D
V
F
D
T
E
G
R
S
A
L
H
L
A
A
E
R
G
Y
L
H
V
C
D
A
L
L
T
N
K
A
F
I
N
S
K
S
R
V
G
R
T
A
L
H
L
A
A
M
N
G
F
T
H
L
V
K
F
L
I
K
D
H
N
A
V
I
D
I
L
T
L
R
K
Q
T
P
L
H
L
A
A
ASGQM
E
V
C
Q
L
L
L
E
L
G
A
N
I
D
AT
D
D
L
G
Q
K
P
I
H
V
A
A
Q
N
N
Y
S
E
V
A
K
L
F
L
Q
Q
-
H
P
S
L
V
N
A
T
S
K
D
G
N
T
C
A
H
I
A
A
M
Q
G
S
V
K
V
I
E
E
L
M
K
F
D
R
S
G
V
ISA
R
N
K
L
T
D
A
T
P
L
Q
L
A
A
E
G
G
H
A
D
V
V
K
A
L
V
R
A
G
A
S
C
T
E
E
N
K
A
G
F
T
A
V
H
L
A
A
Q
N
G
H
G
Q
V
L
D
V
L
K
S
T
N
S
L
R
I
N
S
K
K
L
G
L
T
P
L
H
V
A
A
Y
Y
G
-
Q
A
D
T
V
R
E
L
L
TSVPATVKSETPTGQSLFGDLGTES
G
M
T
P
L
H
L
A
A
F
S
G
N
E
N
V
V
R
L
L
L
N
S
A
-
G
V
Q
V
D
A
A
T
I
E
N
G
Y
N
P
L
H
L
A
C
F
G
---
G
H
M
S
V
V
G
L
L
L
S
R
S
A
E
L
L
Q
S
Q
D
R
N
G
R
T
G
L
H
I
A
A
M
H
G
H
I
Q
M
V
E
I
L
L
G
Q
G
A
E
I
N
A
T
D
R
N
G
W
T
P
L
H
C
A
A
K
A
G
H
L
E
V
V
K
L
L
C
E
A
G
A
S
P
K
S
E
T
N
Y
G
C
A
A
I
W
F
A
A
S
E
G
HNE
V
L
R
Y
L
M
N
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
51.46
43%
16
- C2 -
-
5JHQ
-
TNKS1_HUMAN
D:
[14-473]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
A
L
R
E
L
L
E
A
C
R
N
G
D
V
S
R
V
K
R
L
V
D
A
A
N
V
N
A
K
D
M
A
G
R
K
S
S
P
L
H
F
A
A
G
F
G
R
K
D
V
V
E
H
L
L
Q
M
G
A
N
V
--------
H
A
-----------------------------------
R
D
D
G
G
L
I
P
L
H
N
A
C
S
F
G
H
A
E
V
V
S
L
L
L
C
Q
G
A
D
P
N
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
N
W
N
Y
T
P
L
H
E
A
A
I
K
G
K
I
D
V
C
I
V
L
L
Q
H
G
A
D
P
N
I
R
N
T
D
G
K
S
A
L
D
L
A
D
P
S
A
K
A
V
L
T
G
-----------------------------------------------
E
Y
K
K
D
E
L
L
E
A
A
R
S
G
N
E
E
K
L
M
A
L
L
T
P
-
L
N
V
N
C
H
A
S
D
G
R
K
S
T
P
L
H
L
A
A
G
Y
N
R
V
R
I
V
Q
L
L
L
Q
H
G
A
D
V
H
---
A
K
D
K
G
G
L
V
P
L
H
N
A
C
S
Y
G
H
Y
E
V
T
E
L
L
L
K
H
G
A
C
V
N
A
M
D
L
W
Q
F
T
P
L
H
E
A
A
S
K
N
R
V
E
V
C
S
L
L
L
S
H
G
A
D
P
T
L
V
N
C
H
G
K
S
A
V
D
M
A
P
T
-
P
E
L
R
E
R
L
T
Y
E
F
-------------------------
K
G
H
S
L
L
Q
A
A
R
E
A
D
L
A
K
V
K
K
T
L
A
L
E
-
I
I
N
-
F
-
K
Q
P
Q
S
H
E
T
A
L
H
C
A
V
A
S
LHP
K
R
K
Q
V
T
E
L
L
L
R
K
G
A
N
-
V
N
E
K
N
K
D
F
M
T
P
L
H
V
A
A
E
R
A
H
N
D
V
M
E
V
L
H
K
H
G
A
K
M
N
A
L
D
T
L
G
Q
T
A
L
H
R
A
A
L
A
G
H
L
Q
T
C
R
L
L
L
S
Y
G
S
D
P
S
I
I
S
L
Q
G
F
T
A
A
Q
M
G
N
-
E
A
---
V
Q
Q
I
L
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
50.86
100%
-68
- C1 -
-
5EBT
2
TNKS1_HUMAN
C:
[2-210]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
L
L
D
L
A
P
E
D
K
E
Y
Q
S
V
E
E
E
M
Q
S
T
I
R
E
H
R
D
G
G
N
A
G
G
I
F
N
R
Y
N
V
I
R
I
Q
K
V
V
N
K
K
L
R
E
R
F
C
H
R
Q
K
E
V
S
E
E
N
H
N
H
H
N
E
R
M
L
F
H
G
S
P
F
I
N
A
I
I
H
K
G
F
D
E
R
H
A
Y
I
G
G
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
T
H
K
D
R
S
C
Y
I
C
H
R
Q
M
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
T
I
K
M
A
H
A
P
P
G
H
H
S
V
I
G
R
P
S
V
N
G
L
A
Y
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
K
P
E
-------------
29
HHSearch
50.57
37%
-79
- C2 -
-
1N11
-
ANK1_HUMAN
A:
[15-404]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
P
L
H
V
A
S
F
M
G
H
L
P
I
V
K
N
L
L
Q
R
G
A
-
S
P
N
V
S
N
V
K
V
E
T
P
L
H
M
A
A
R
A
G
H
T
E
V
A
K
Y
L
L
Q
N
K
A
K
V
--------
N
A
-----------------------------------
K
A
K
D
D
Q
T
P
L
H
C
A
A
R
I
G
H
T
N
M
V
K
L
L
L
E
N
N
A
N
P
N
L
A
T
T
A
G
-----------------------------------------------------------------------------------------------------------------------------
H
T
P
L
H
I
A
A
R
E
G
---
H
V
E
T
V
L
A
L
L
E
K
E
A
S
Q
A
C
M
T
K
K
G
F
T
P
L
H
V
A
A
K
Y
G
K
V
R
V
A
E
L
L
L
E
R
D
A
H
P
N
A
A
G
K
N
G
L
T
P
L
H
V
A
V
H
H
N
N
L
D
I
V
K
L
L
L
P
R
G
G
S
-
P
H
S
P
--------------------------------------------------------------------
A
W
N
G
Y
T
P
L
H
I
A
A
K
Q
N
Q
V
E
V
A
R
S
L
L
Q
Y
G
G
S
A
N
---
A
E
S
V
Q
G
V
T
P
L
H
L
A
A
Q
E
G
H
A
E
M
V
A
L
L
L
S
K
Q
A
N
G
N
L
G
N
K
S
G
L
T
P
L
H
L
V
A
Q
E
G
H
V
P
V
A
D
V
L
I
K
H
G
V
M
V
D
A
T
T
R
M
-----------------------------------------------------------------------------------
G
Y
T
P
L
H
V
A
S
H
Y
---
G
N
I
K
L
V
K
F
L
L
Q
H
Q
A
D
-
V
N
A
K
T
K
L
G
Y
S
P
L
H
Q
A
A
Q
Q
G
H
T
D
I
V
T
L
L
L
K
N
G
A
S
P
N
E
V
S
S
D
G
T
T
P
L
A
I
A
K
R
L
G
Y
I
S
V
T
D
V
L
K
V
V
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
50.10
99%
-69
- C1 -
-
4W6E
1
A:
[3-211]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
L
L
D
L
A
P
E
D
K
E
Y
Q
S
V
E
E
E
M
Q
S
T
I
R
E
H
R
D
G
G
N
A
G
G
I
F
N
R
Y
N
V
I
R
I
Q
K
V
V
N
K
K
L
R
E
R
F
C
H
R
Q
K
E
V
S
E
E
N
H
N
H
H
N
E
R
M
L
F
H
G
S
P
F
I
N
A
I
I
H
K
G
F
D
E
R
H
A
Y
I
G
G
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
T
H
K
D
R
S
C
Y
I
C
H
R
Q
M
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
T
I
K
M
A
H
A
P
P
G
H
H
S
V
I
G
R
P
S
V
-
G
L
A
Y
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
K
P
E
-------------
16
PsiBlast_PDB
49.83
99%
-60
- C1 -
-
5ECE
3
TNKS1_HUMAN
A:
[2-213]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
I
L
L
D
L
A
P
E
D
K
E
Y
Q
S
V
E
E
E
M
Q
S
T
I
R
E
H
R
D
G
G
N
A
G
G
I
F
N
R
Y
N
V
I
R
I
Q
K
V
V
N
K
K
L
R
E
R
F
C
H
R
Q
K
E
V
S
E
E
N
H
N
H
H
N
E
R
M
L
F
H
G
S
P
F
I
N
A
I
I
H
K
G
F
D
E
R
H
A
Y
-----
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
T
H
K
D
R
S
C
Y
I
C
H
R
Q
M
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
T
I
K
M
A
H
A
P
P
G
H
H
S
V
I
G
R
P
S
V
N
G
L
A
Y
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
K
P
E
A
P
-----------
21
HHSearch
49.72
33%
8
- C2 -
-
5Y4D
-
ANK2_HUMAN
A:
[71-720]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
F
L
R
A
A
R
A
G
N
L
D
K
V
V
E
Y
L
K
G
G
I
D
I
N
T
C
--
N
Q
N
G
L
N
A
L
H
L
A
A
K
E
G
H
V
G
L
V
Q
E
L
L
G
R
G
S
S
---------------------------------------------------------------------------
V
D
S
A
T
K
K
G
N
T
A
L
H
I
A
S
L
A
G
Q
A
E
V
V
K
V
L
V
K
E
G
A
N
I
N
A
Q
S
Q
N
G
F
T
P
L
Y
M
A
A
Q
E
N
H
I
D
V
V
K
Y
L
L
E
N
G
A
N
Q
S
T
A
T
E
D
G
F
T
P
L
A
V
A
L
Q
Q
G
H
N
Q
A
V
A
I
L
L
E
N
D---------
V
R
L
P
A
L
H
I
A
A
R
K
D
D
T
K
S
A
A
L
L
L
Q
N
D
H
N
ADVQSKM
M
V
N
R
T
T
E
S
G
F
T
P
L
H
I
A
A
H
Y
G
N
V
N
V
A
T
L
L
L
N
R
G
A
-
A
V
D
F
T
A
R
N
G
I
T
P
L
H
V
A
S
K
R
G
N
T
N
M
V
K
L
L
L
D
R
G
G
Q
I
--------
D
A
-----------------------------------
K
T
R
D
G
L
T
P
L
H
C
A
A
R
S
G
H
D
Q
V
V
E
L
L
L
E
R
G
A
P
L
L
A
R
T
K
N
G
L
S
P
L
-----------------------------------------------------------------------------------------------------------------------------
H
M
A
A
Q
G
D
---
H
V
E
C
V
K
H
L
L
Q
H
K
A
P
V
D
D
V
T
L
D
Y
L
T
A
L
H
V
A
A
H
C
G
H
Y
R
V
T
K
L
L
L
D
K
R
A
N
P
N
A
R
A
L
N
G
F
T
P
L
H
I
A
C
K
K
N
R
I
K
V
M
E
L
L
V
K
Y
G
A
S
-
I
Q
A
I
T
E
S
G
---------------------------------
L
T
P
I
H
V
A
A
F
M
G
H
L
N
I
V
L
L
L
L
Q
N
G
A
S
P
D
V
T
--
N
I
R
G
E
T
A
L
H
M
A
A
R
A
G
Q
V
E
V
V
R
C
L
L
R
N
G
A
L
V
D
---
A
R
A
R
E
E
Q
T
P
L
H
I
A
S
R
L
G
K
T
E
I
V
Q
L
L
L
Q
H
M
A
H
P
D
A
A
T
T
N
G
Y
T
P
L
H
I
S
A
R
E
G
Q
V
D
V
A
S
V
L
L
E
A
G
A
A
H
S
L
A
T
K
K
G
F
T
P
L
H
V
-----------------------------------------------
A
A
K
Y
G
S
L
D
V
A
K
L
L
L
Q
R
R
-
A
A
-
A
D
-
S
A
G
K
N
G
L
T
P
L
H
V
A
A
H
Y
---
D
N
Q
K
V
A
L
L
L
L
E
K
G
A
S
-
P
H
A
T
A
K
N
G
Y
T
P
L
H
I
A
A
K
K
N
Q
M
Q
I
A
S
T
L
L
N
Y
G
A
E
T
N
I
V
T
K
Q
G
V
T
P
L
H
L
A
S
Q
E
G
H
T
D
M
V
T
L
L
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
49.57
99%
-62
- C1 -
-
5EBT
2
TNKS1_HUMAN
A:
[2-210]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
L
L
D
L
A
P
E
D
K
E
Y
Q
S
V
E
E
E
M
Q
S
T
I
R
E
H
R
D
G
G
N
A
G
G
I
F
N
R
Y
N
V
I
R
I
Q
K
V
V
N
K
K
L
R
E
R
F
C
H
R
Q
K
E
V
S
E
E
N
H
N
H
H
N
E
R
M
L
F
H
G
S
P
F
I
N
A
I
I
H
K
G
F
D
E
R
H
A
Y
I
G
G
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
T
H
K
D
R
S
C
Y
I
C
H
R
Q
M
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
T
I
K
M
A
H
A
P
P
G
H
H
S
V
I
G
R
P
S
V
N
G
L
A
Y
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
K
P
E
-------------
17
PsiBlast_PDB
49.55
99%
-67
- C1 -
-
4TOR
1
TNKS1_HUMAN
A:
[26-234]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
I
L
L
D
L
A
P
E
D
K
E
Y
Q
S
V
E
E
E
M
Q
S
T
I
R
E
H
R
D
G
G
N
A
G
G
I
F
N
R
Y
N
V
I
R
I
Q
K
V
V
N
K
K
L
R
E
R
F
C
H
R
Q
K
E
V
S
E
E
N
H
N
H
H
N
E
R
M
L
F
H
G
S
P
F
I
N
A
I
I
H
K
G
F
D
E
R
H
A
Y
I
G
G
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
T
H
K
D
R
S
C
Y
I
C
H
R
Q
M
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
T
I
K
M
A
H
A
P
P
G
H
H
S
V
I
G
R
P
S
V
N
G
L
A
Y
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
K
P
--------------
12
PsiBlast_PDB
49.49
99%
-67
- C1 -
-
3UH4
2
TNKS1_HUMAN
A:
[2-213]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
I
L
L
D
L
A
P
E
D
K
E
Y
Q
S
V
E
E
E
M
Q
S
T
I
R
E
H
R
D
G
G
N
A
G
G
I
F
N
R
Y
N
V
I
R
I
Q
K
V
V
N
K
K
L
R
E
R
F
C
H
R
Q
K
E
V
S
E
E
N
H
N
H
H
N
E
R
M
L
F
H
G
S
P
F
I
N
A
I
I
H
K
G
F
D
E
R
H
---
G
G
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
T
H
K
D
R
S
C
Y
I
C
H
R
Q
M
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
T
I
K
M
A
H
A
P
P
G
H
H
S
V
I
G
R
P
S
V
N
G
L
A
Y
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
K
P
E
A
P
-----------
7
PsiBlast_PDB
49.32
96%
-66
- C1 -
-
4UW1
3
TNKS1_HUMAN
A:
[38-246]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
I
L
L
D
L
A
P
E
D
K
E
Y
Q
S
V
E
E
E
M
Q
S
T
I
R
E
H
R
D
G
G
N
A
G
G
I
F
N
R
Y
N
V
I
R
I
Q
K
V
V
N
K
K
L
R
E
R
F
C
H
R
Q
K
E
V
S
E
E
N
H
N
H
H
N
E
R
M
L
F
H
G
S
P
F
I
N
A
I
I
H
K
G
F
D
E
R
H
A
Y
I
G
G
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
T
H
K
D
R
S
C
Y
I
C
H
R
Q
M
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
T
I
K
M
A
H
A
P
P
G
H
H
S
V
I
G
R
P
S
V
N
G
L
A
Y
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
K
P
--------------
11
PsiBlast_PDB
49.30
99%
-72
- C1 -
-
3UH2
2
TNKS1_HUMAN
A:
[2-210]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
I
L
L
D
L
A
P
E
D
K
E
Y
Q
S
V
E
E
E
M
Q
S
T
I
R
E
H
R
D
G
G
N
A
G
G
I
F
N
R
Y
N
V
I
R
I
Q
K
V
V
N
K
K
L
R
E
R
F
C
H
R
Q
K
E
V
S
E
E
N
H
N
H
H
N
E
R
M
L
F
H
G
S
P
F
I
N
A
I
I
H
K
G
F
D
E
R
H
A
---
G
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
T
H
K
D
R
S
C
Y
I
C
H
R
Q
M
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
T
I
K
M
A
H
A
P
P
G
H
H
S
V
I
G
R
-------
Y
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
K
P
--------------
4
PsiBlast_PDB
49.11
96%
-58
- C1 -
-
2RF5
1
A:
[37-247]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
G
T
I
L
L
D
L
A
P
E
D
K
E
Y
Q
S
V
E
E
E
M
Q
S
T
I
R
E
H
R
D
G
G
N
A
G
G
I
F
N
R
Y
N
V
I
R
I
Q
K
V
V
N
K
K
L
R
E
R
F
C
H
R
Q
K
E
V
S
E
E
N
H
N
H
H
N
E
R
M
L
F
H
G
S
P
F
I
N
A
I
I
H
K
G
F
D
E
R
H
A
Y
I
G
G
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
T
H
K
D
R
S
C
Y
I
C
H
R
Q
M
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
T
I
K
M
A
H
A
P
P
G
H
H
S
V
I
G
R
P
----
L
A
Y
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
K
P
E
-------------