@TOME V2.3
(Mar 2018)
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : TNKS2_HUMAN: (2018-07-14 )
MSGRRCAGGGAACASAAAEAVEPAARELFEACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSADDVSALLTAAMPPSALPSCYKPQVLNGVRSPGATADALSSGPSSPSSLSAASSLDNLSGSFSELSSVVSSSGTEGASSLEKKEVPGVDFSITQFVRNLGLEHLMDIFEREQITLDVLVEMGHKELKEIGINAYGHRHKLIKGVERLISGQQGLNPYLTLNTSGSGTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMKMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPEGMVDG
Atome Classification :
(20 SA)
.........10........20........30........40......-.-.50........60........70........80..-..---------------------------------------....90........100.......110.....--..120.......130.......140.....-..150.......160.......170------------..-------......180.......190.......200.-------......210.......220.......230.......240-.......250....-...260.......270-------........280.......290.......300.......-310.......320.----.---...-----------------------------------------.------------------.330.--------------------------------------------.-.....340.......350.....----------..360.......370...------....380.......390....----------------------------------------...400.......410.......420.......430----------------------------------.......440.......450.......460.......470...----....480.-...----...490.......500.......510..-.-....--520.......530.......540.......550........560------------------------------------.......570....--------------------...580.......590.......600.......610.......-------------620.......630.-.-.....640..-------------------------.....650.......660......-.670.-......680.......690.......700..-.....710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160...
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MSGRRCAGG
G
A
A
C
A
S
A
A
A
E
AV
E
P
A
A
R
E
L
F
E
A
C
RNG
D
V
E
R
V
K
R
LV
T
P
E
-K-VNSRDTAGRKST
P
L
H
F
AAGF
G
R
K
D
V
V
E
Y
L
L
QNGA
N
-
V
Q
---------------------------------------ARDDG
G
L
I
PLHNACSF
G
H
A
E
V
V
N
L
L
L
RHGADP--NARDNWNYTP
L
H
E
A
A
IKGK
I
D
V
C
I
V
L
L
QHG-AEP
T
I
RNTDG
R
T
A
L
DLADPSA
K
A
V
-------------
L
T-------GEY
K
K
D
E
L
L
E
S
A
RSG
N
E
E
K
M
M
A
L
LTPL
N
V
N
-------
C
HASDGRKST
P
L
H
L
AAGY
N
R
V
K
I
V
Q
L
L
L
QHGADVHAKDK-G
D
L
VPLHNACSY
G
H
-
Y
E
V
T
E
L
L
V
KHGACV
N
--------
A
M
D
L
WQFT
P
L
H
E
A
ASK
N
R
V
E
V
C
S
L
L
L
SYGADP
T
L
L
NCH-NKSAIDLAP
T
P
Q
L
K
----
E
---
R
L
A
-----------------------------------------
Y
------------------EFK
G
H
--------------------------------------------
S
-
L
L
Q
A
A
R
E
A
D
V
T
R
I
K
K
H
L
S
L
E
M
VN----------FKHPQT
H
E
T
A
L
H
CAAASP------Y
P
K
R
K
Q
I
C
E
L
L
L
RKGANI
N
E
K
----------------------------------------
T
K
E
F
L
T
P
L
HVASEKAH
N
D
V
V
E
V
V
V
KHEAK
V
N
A
L
D
N
L----------------------------------
G
Q
T
S
L
H
R
A
A
YC
G
H
L
Q
T
C
R
L
L
L
SYGCDP
N
I
I
S
LQG
F
T
A
L
QMG
N
E
----
N
V
Q
Q
L
L
Q
E
-
G
I
S----LGN
S
E
A
D
R
Q
L
L
E
A
AKAG
D
V
E
T
V
K
K
L
C
TV-Q-SVNC--RDIEGRQST
P
L
H
F
AAGY
N
R
V
S
V
V
E
Y
L
L
QHGAD-VHAKDKG
G
L
V
P------------------------------------LHNACSY
G
H
Y
E
V
A
E
--------------------
L
L
V
KHG
A
V
V
N
V
A
D
L
WKFT
P
L
H
E
A
A
AK
G
K
Y
E
I
C
K
L
L
L
QHGADPT-------------KKNRDGNTP
L
D
L
VK-D-GD
T
D
I
Q
D
L
L
R-------------------------G
D
A
A
L
L
D
A
A
K
K
G
C
L
A
R
V
K
KLSSPD-NVNCR-DTQGRHST
P
L
H
L
AAGYN
N
L
E
V
A
E
Y
L
L
QHGAD-VNAQDKG
G
L
I
PLHNAASYG
H
V
D
V
A
A
L
L
I
KYNACVNATDKWAF
T
P
L
H
E
A
A
QK
G
R
T
Q
L
C
A
L
L
L
AHGADPTLKNQEGQTP
L
D
L
VS
A
D
D
V
S
A
L
L
T
AAMPPSALPSCY
K
P
Q
V
LNGVRSPGAT
A
D
A
LSSGPSSPSSL
S
A
A
S
S
L
D
NLSG
S
F
S
E
L
S
S
V
V
SSSGTEGASSLEKKEVPGVD
F
S
I
T
Q
F
V
R
N
L
G
L
E
H
L
M
D
I
F
E
R
E
Q
I
T
L
D
V
L
V
E
M
G
H
K
E
L
K
E
IGINAYG
H
R
H
K
L
I
K
G
V
E
R
L
ISGQQGLN
P
Y
L
T
L
NTSGS
G
T
I
L
I
DLSPD
D
K
E
F
Q
S
V
E
E
E
M
Q
S
T
V
R
E
HRDGGHAGGIFNR
Y
N
I
L
K
I
Q
K
V
C
N
K
K
L
W
E
R
Y
T
H
R
R
K
EVSEENHNHANE
R
M
L
FHG
S
P
F
V
N
A
I
I
HKGF
D
E
R
H
A
Y
IGGMFG
A
G
I
Y
F
AENSSKSN
Q
Y
V
Y
G
IGGGTGCPVHKDR
S
C
Y
I
C
H
R
Q
L
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
A
M
K
MAHSPPGHHSVTGRPSV
N
G
L
A
L
A
E
Y
V
I
YRGEQAY
P
E
Y
L
I
T
Y
Q
I
MRPEGMVDG
42
HHSearch
66.13
84%
-76
- C2 -
-
5JHQ
-
TNKS1_HUMAN
D:
[13-471]
---------------------
S
G
A
L
R
E
L
L
E
A
C
R
N
G
D
V
S
R
V
K
R
L
V
D
A
A
-
N
-
V
N
A
K
D
M
A
G
R
K
S
S
P
L
H
F
A
A
G
F
G
R
K
D
V
V
E
H
L
L
Q
M
G
A
N
-
V
H
---------------------------------------
A
R
D
D
G
G
L
I
P
L
H
N
A
C
S
F
G
H
A
E
V
V
S
L
L
L
C
Q
G
A
D
P
--
N
A
R
D
N
W
N
Y
T
P
L
H
E
A
A
I
K
G
K
I
D
V
C
I
V
L
L
Q
H
G
-
A
D
P
N
I
R
N
T
D
G
K
S
A
L
D
L
A
D
P
S
A
K
A
V
-------------
L
T
-------
G
E
Y
K
K
D
E
L
L
E
A
A
R
S
G
N
E
E
K
L
M
A
L
L
T
P
L
N
V
N
-------
C
H
A
S
D
G
R
K
S
T
P
L
H
L
A
A
G
Y
N
R
V
R
I
V
Q
L
L
L
Q
H
G
A
D
V
H
A
K
D
K
-
G
G
L
V
P
L
H
N
A
C
S
Y
G
H
-
Y
E
V
T
E
L
L
L
K
H
G
A
C
V
N
--------
A
M
D
L
W
Q
F
T
P
L
H
E
A
A
S
K
N
R
V
E
V
C
S
L
L
L
S
H
G
A
D
P
T
L
V
N
C
H
-
G
K
S
A
V
D
M
A
P
T
P
E
L
R
----
E
---
R
L
T
-----------------------------------------
Y
------------------
E
F
K
G
H
--------------------------------------------
S
-
L
L
Q
A
A
R
E
A
D
L
A
K
V
K
K
T
L
A
L
E
I
I
N
----------
F
K
Q
P
Q
S
H
E
T
A
L
H
C
A
V
A
S
L
------
H
P
K
R
K
Q
V
T
E
L
L
L
R
K
G
A
N
V
N
E
K
----------------------------------------
N
K
D
F
M
T
P
L
H
V
A
A
E
R
A
H
N
D
V
M
E
V
L
H
K
H
G
A
K
M
N
A
L
D
T
L
----------------------------------
G
Q
T
A
L
H
R
A
A
L
A
G
H
L
Q
T
C
R
L
L
L
S
Y
G
S
D
P
S
I
I
S
L
Q
G
F
T
A
A
Q
M
G
N
E
----
A
V
Q
Q
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
63.02
82%
-77
- C2 -
-
5JHQ
-
TNKS1_HUMAN
A:
[14-475]
----------------------
G
A
L
R
E
L
L
E
A
C
R
N
G
D
V
S
R
V
K
R
L
V
D
A
A
-
N
-
V
N
A
K
D
M
A
G
R
K
S
S
P
L
H
F
A
A
G
F
G
R
K
D
V
V
E
H
L
L
Q
M
G
A
N
-
V
H
---------------------------------------
A
R
D
D
G
G
L
I
P
L
H
N
A
C
S
F
G
H
A
E
V
V
S
L
L
L
C
Q
G
A
D
P
--
N
A
R
D
N
W
N
Y
T
P
L
H
E
A
A
I
K
G
K
I
D
V
C
I
V
L
L
Q
H
G
-
A
D
P
N
I
R
N
T
D
G
K
S
A
L
D
L
A
D
P
S
A
K
A
V
-------------
L
T
-------
G
E
Y
K
K
D
E
L
L
E
A
A
R
S
G
N
E
E
K
L
M
A
L
L
T
P
L
N
V
N
-------
C
H
A
S
D
G
R
K
S
T
P
L
H
L
A
A
G
Y
N
R
V
R
I
V
Q
L
L
L
Q
H
G
A
D
V
H
A
K
D
K
-
G
G
L
V
P
L
H
N
A
C
S
Y
G
H
-
Y
E
V
T
E
L
L
L
K
H
G
A
C
V
N
--------
A
M
D
L
W
Q
F
T
P
L
H
E
A
A
S
K
N
R
V
E
V
C
S
L
L
L
S
H
G
A
D
P
T
L
V
N
C
H
-
G
K
S
A
V
D
M
A
P
T
P
E
L
R
----
E
---
R
L
T
-----------------------------------------
Y
------------------
E
F
K
G
H
--------------------------------------------
S
-
L
L
Q
A
A
R
E
A
D
L
A
K
V
K
K
T
L
A
L
E
I
I
N
----------
F
K
Q
P
Q
S
H
E
T
A
L
H
C
A
V
A
S
L
------
H
P
K
R
K
Q
V
T
E
L
L
L
R
K
G
A
N
V
N
E
K
----------------------------------------
N
K
D
F
M
T
P
L
H
V
A
A
E
R
A
H
N
D
V
M
E
V
L
H
K
H
G
A
K
M
N
A
L
D
T
L
----------------------------------
G
Q
T
A
L
H
R
A
A
L
A
G
H
L
Q
T
C
R
L
L
L
S
Y
G
S
D
P
S
I
I
S
L
Q
G
F
T
A
A
Q
M
G
N
E
----
A
V
Q
Q
I
L
S
E
-
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
54.09
26%
14
- C2 -
-
5VKQ
-
?
D:
[128-1195]
------------------------
M
T
P
L
M
Y
A
T
K
D
N
K
T
A
I
M
D
R
M
I
E
L
G
A
D
-
V
G
A
R
N
N
D
--
N
Y
N
V
L
H
I
A
A
M
Y
S
R
E
D
V
V
K
L
L
L
T
K
R
G
V
D
P
F
STGGSRSQTAVHLVSSRQTGTATNILRALLAAAGKDIRL
K
A
D
G
R
G
K
I
P
L
L
L
A
V
E
S
G
N
Q
S
M
C
R
E
L
L
A
A
Q
T
A
E
QL
K
A
T
T
A
N
G
D
T
A
L
H
L
A
A
R
R
R
D
V
D
M
V
R
I
L
V
D
Y
G
-
T
N
V
D
T
Q
N
G
E
G
Q
T
P
L
H
I
A
A
A
E
G
D
E
A
LLKYFYGVRASAS
I
A
-------
D
N
Q
D
R
T
P
M
H
L
A
A
E
N
G
H
A
H
V
I
E
I
L
A
D
K
F
K
A
S
-------
I
F
E
R
T
K
D
G
S
T
L
M
H
I
A
S
L
N
G
H
A
E
C
A
T
M
L
F
K
K
G
V
Y
L
H
M
P
N
K
-
D
G
A
R
S
I
H
T
A
A
A
Y
G
H
-
T
G
I
I
N
T
L
L
Q
K
G
E
K
V
D
--------
V
T
T
N
D
N
Y
T
A
L
H
I
A
V
E
S
A
K
P
A
V
V
E
T
L
L
G
F
G
A
D
V
H
V
R
G
G
K
L
R
E
T
P
L
H
I
A
A
R
V
K
D
G
DRCA
L
---
M
L
L
KSGASPNLTTDDCLTPVHVAARHGNLATLMQLLEDEGDPLY
K
------------------
S
N
T
G
E
--------------------------------------------
T
P
L
H
M
A
C
R
A
C
H
P
D
I
V
R
H
L
I
E
T
V
K
E
K
HGPDKATTYI
N
S
V
N
E
D
G
A
T
A
L
H
Y
T
C
Q
I
T
KEEVKI
P
E
S
D
K
Q
I
V
R
M
L
L
E
N
G
A
D
V
T
L
Q
TKTALETAFHYCAVAGNNDVLMEMISHMNPTDIQKAMNRQ
S
S
V
G
W
T
P
L
L
I
A
C
H
R
G
H
M
E
L
V
N
N
L
L
A
N
H
A
R
V
D
V
F
D
T
E
----------------------------------
G
R
S
A
L
H
L
A
A
E
R
G
Y
L
H
V
C
D
A
L
L
T
N
K
A
F
I
N
S
K
S
R
V
G
R
T
A
L
H
L
A
A
M
NGFT
H
L
V
K
F
L
I
K
-
D
H
N
AVID
I
L
T
L
R
K
Q
T
P
L
H
L
A
A
A
S
G
Q
M
E
V
C
Q
L
L
L
E
L
-
G
A
N
I
D
A
--
T
--
D
D
L
G
Q
K
P
I
H
V
A
A
Q
N
N
Y
S
E
V
A
K
L
F
L
Q
Q
H
P
S
L
V
N
A
T
S
K
D
G
N
T
C
AHIAAMQGSVKVIEELMKFDRSGVISARNKLTDATP
L
Q
L
A
A
E
G
G
H
A
D
V
V
K
--------------------
A
L
V
R
A
G
A
S
C
T
E
E
N
K
A
G
F
T
A
V
H
L
A
A
Q
N
G
H
G
Q
V
L
D
V
L
K
S
T
N
S
L
R
I
-------------
N
S
K
K
L
G
L
T
P
L
H
V
A
A
Y
Y
-
G
Q
A
D
T
V
R
E
L
L
TSVPATVKSETPTGQSLFGDLGTES
G
M
T
P
L
H
L
A
A
F
S
G
N
E
N
V
V
R
L
L
L
N
S
A
-
G
V
Q
V
D
A
A
T
I
E
N
G
Y
N
P
L
H
L
A
C
F
G
G
H
M
S
V
V
G
L
L
L
S
R
S
A
E
L
L
Q
S
Q
D
R
N
G
R
T
G
L
H
I
A
A
M
H
G
H
I
Q
M
V
E
I
L
L
G
Q
G
A
E
I
N
A
T
D
R
N
G
W
T
P
L
H
C
A
A
K
A
G
H
L
E
V
V
K
L
L
C
E
A
G
A
S
P
K
S
E
T
N
Y
G
C
A
A
I
W
F
A
A
S
E
G
H
N
E
V
L
R
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
52.41
32%
-19
- C2 -
-
5Y4D
-
ANK2_HUMAN
A:
[70-718]
------------------------------------------------------------
N
A
S
F
L
R
A
A
R
A
G
N
L
D
K
V
V
E
Y
L
K
G
G
I
D
-
I
N
---------------------------------------
T
C
N
Q
N
G
L
N
A
L
H
L
A
A
K
E
G
H
V
G
L
V
Q
E
L
L
G
R
G
S
S
V
--
D
S
A
T
K
K
G
N
T
A
L
H
I
A
S
L
A
G
Q
A
E
V
V
K
V
L
V
K
E
G
-
A
N
I
N
A
Q
S
Q
N
G
F
T
P
L
Y
M
A
A
Q
----------------------------------------
E
N
H
I
D
V
V
K
Y
L
L
E
N
G
-
A
N
-------
Q
S
T
A
T
E
D
G
F
T
P
L
A
V
A
L
Q
Q
G
H
N
Q
A
V
A
I
L
L
E
N
D
---------
V
R
L
P
A
L
H
I
A
A
R
K
D
D
-
T
K
S
A
A
L
L
L
Q
N
D
H
N
A
D
VQSKMMVN
R
T
T
E
S
G
F
T
P
L
H
I
A
A
H
Y
G
N
V
N
V
A
T
L
L
L
N
R
G
A
A
V
D
F
T
A
R
N
-
G
I
T
P
L
H
------------------------------------------------------------------------------------------------------------------------------------
V
A
S
K
R
G
N
T
N
M
V
K
L
L
L
D
R
G
G
Q
I
----------
D
A
K
T
R
D
G
L
T
P
L
H
C
A
A
R
S
G
---------
H
D
Q
V
V
E
L
L
L
E
R
G
A
P
L
L
A
R
----------------------------------------
T
K
N
G
L
S
P
L
H
M
A
A
Q
G
D
H
V
E
C
V
K
H
L
L
Q
H
K
A
P
V
D
D
V
T
L
D
----------------------------------
Y
L
T
A
L
H
V
A
A
H
C
G
H
Y
R
V
T
K
L
L
L
D
K
R
A
N
P
N
A
R
A
L
N
G
F
-----------------------------------
T
P
L
H
I
A
C
K
K
N
R
I
K
V
M
E
L
L
V
K
Y
-
G
--
A
S
I
--
Q
A
I
T
E
S
G
L
T
P
I
H
V
A
A
F
M
G
H
L
N
I
V
L
L
L
L
Q
N
G
A
S
-
P
D
V
T
N
I
R
G
E
T
A
------------------------------------
L
H
M
A
A
R
A
G
Q
V
E
V
V
R
--------------------
C
L
L
R
N
G
A
L
V
D
A
R
A
R
E
E
Q
T
P
L
H
I
A
S
R
L
G
K
T
E
I
V
Q
L
L
L
Q
H
M
A
H
P
D
-------------
A
A
T
T
N
G
Y
T
P
L
H
I
-----------------------------------------------
S
A
R
E
G
Q
V
D
V
A
S
V
L
L
E
A
G
A
A
H
S
L
A
---
T
K
K
G
F
T
P
L
H
V
A
A
K
Y
G
S
L
D
V
A
K
L
L
L
Q
R
R
A
A
-
A
D
S
A
G
K
N
G
L
T
P
L
H
V
A
A
H
Y
D
N
Q
K
V
A
L
L
L
L
E
K
G
A
S
P
H
A
T
A
K
N
G
Y
T
P
L
H
I
A
A
K
K
N
Q
M
Q
I
A
S
T
L
L
N
Y
G
A
E
T
N
I
V
T
K
Q
G
V
T
P
L
H
L
A
S
Q
E
G
H
T
D
M
V
T
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
46.68
34%
-79
- C2 -
-
5Y4F
-
ANK2_HUMAN
A:
[2-389]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
T
P
I
H
V
A
A
F
M
G
H
L
N
I
V
L
L
L
L
Q
N
G
A
S
P
D
V
T
N
I
-
R
G
E
T
A
L
H
M
A
A
R
A
G
Q
-
V
E
V
V
R
C
L
L
R
N
G
A
L
V
D
--------
A
R
A
R
E
E
Q
T
P
L
H
I
A
S
R
L
G
K
T
E
I
V
Q
L
L
L
Q
H
M
A
H
P
D
A
A
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
N
G
Y
T
P
L
H
I
S
A
R
E
G
---------
Q
V
D
V
A
S
V
L
L
E
A
G
A
A
H
S
L
A
----------------------------------------
T
K
K
G
F
T
P
L
H
V
A
A
K
Y
G
S
L
D
V
A
K
L
L
L
Q
R
R
A
A
A
D
S
A
G
K
N
----------------------------------
G
L
T
P
L
H
V
A
A
H
Y
D
N
Q
K
V
A
L
L
L
L
E
K
G
A
S
P
H
A
T
A
-------------------------------------------------------------------------
K
N
G
Y
T
P
L
H
I
A
A
K
K
N
Q
M
Q
I
A
S
T
L
L
N
Y
G
A
E
-
T
N
I
V
T
K
Q
G
V
T
P
------------------------------------
L
H
L
A
S
Q
E
G
H
T
D
M
V
T
--------------------
L
L
L
D
K
G
A
N
I
H
M
S
T
K
S
G
L
T
S
L
H
L
A
A
Q
E
D
K
V
N
V
A
D
I
L
T
K
H
G
A
D
Q
D
-------------
A
H
T
K
-----------------------------------------------------------------------------------
L
G
Y
T
P
L
I
V
A
C
H
Y
G
N
V
K
M
V
N
F
L
L
K
Q
G
A
N
-
V
N
A
K
T
K
N
G
Y
T
P
L
H
Q
A
A
Q
Q
G
H
T
H
I
I
N
V
L
L
Q
H
G
A
K
P
N
A
T
T
A
N
G
N
T
A
L
A
I
A
K
R
L
G
Y
I
S
V
V
D
T
L
K
V
V
T
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
46.30
33%
12
- C2 -
-
5Y4D
-
ANK2_HUMAN
A:
[69-720]
-----------------------
S
N
A
S
F
L
R
A
A
R
A
G
N
L
D
K
V
V
E
Y
L
K
G
G
I
D
-
I
N
T
C
N
--
Q
N
G
L
N
A
L
H
L
A
A
K
E
G
H
V
G
L
V
Q
E
L
L
G
R
G
S
S
-
V
D
---------------------------------------
S
A
T
K
K
G
N
T
A
L
H
I
A
S
L
A
G
Q
A
E
V
V
K
V
L
V
K
E
G
A
N
I
--
N
A
Q
S
Q
N
G
F
T
P
L
Y
M
A
A
Q
E
N
H
I
D
V
V
K
Y
L
L
E
N
G
-
A
N
Q
S
T
A
T
E
D
G
F
T
P
L
A
V
A
L
Q
Q
G
H
N
Q
-------------
A
V
A
I
L
L
E
N
D--
V
R
L
P
A
L
H
I
A
A
R
K
D
D
T
K
S
A
A
L
L
L
Q
N
D
H
N
A
DVQSKMM
V
N
R
T
T
E
S
G
F
T
P
L
H
I
A
A
H
Y
G
N
V
N
V
A
T
L
L
L
N
R
G
A
A
V
D
F
T
A
R
-
N
G
I
T
P
L
H
V
A
S
K
R
G
N
-
T
N
M
V
K
L
L
L
D
R
G
G
Q
I
D
--------
A
K
T
R
D
G
L
T
P
L
H
C
A
A
R
S
G
H
D
Q
V
V
E
L
L
L
E
R
G
A
P
L
L
A
R
T
K
N
-
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
L
H
M
A
A
Q
G
D
---------
H
V
E
C
V
K
H
L
L
Q
H
K
A
P
V
D
D
V
----------------------------------------
T
L
D
Y
L
T
A
L
H
V
A
A
H
C
G
H
Y
R
V
T
K
L
L
L
D
K
R
A
N
P
N
A
R
A
L
N
----------------------------------
G
F
T
P
L
H
I
A
C
K
K
N
R
I
K
V
M
E
L
L
V
K
Y
G
A
S
I
Q
A
I
T
E
S
G
L
T
P
-----------------------------------
I
H
V
A
A
F
M
G
H
L
N
I
V
L
L
L
L
Q
N
G
A
-
S
P
D
V
----
T
N
I
R
G
E
T
A
L
H
M
A
A
R
A
G
Q
V
E
V
V
R
C
L
L
R
N
G
A
L
-
V
D
A
R
A
R
E
E
Q
T
P
------------------------------------
L
H
I
A
S
R
L
G
K
T
E
I
V
Q
--------------------
L
L
L
Q
H
M
A
H
P
D
A
A
T
T
N
G
Y
T
P
L
H
I
S
A
R
E
G
Q
V
D
V
A
S
V
L
L
E
A
G
A
A
H
S
-------------
L
A
T
K
K
G
F
T
P
L
H
V
-----------------------------------------------
A
A
K
Y
G
S
L
D
V
A
K
L
L
L
Q
R
R
-
A
A
A
-
D
-
S
A
G
K
N
G
L
T
P
L
H
V
A
A
H
Y
D
N
Q
K
V
A
L
L
L
L
E
K
G
A
S
-
P
H
A
T
A
K
N
G
Y
T
P
L
H
I
A
A
K
K
N
Q
M
Q
I
A
S
T
L
L
N
Y
G
A
E
T
N
I
V
T
K
Q
G
V
T
P
L
H
L
A
S
Q
E
G
H
T
D
M
V
T
L
L
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
46.12
25%
17
- C2 -
-
5VKQ
-
?
D:
[233-1212]
-----------------------
G
K
I
P
L
L
L
A
V
E
S
G
N
Q
S
M
C
R
E
L
L
A
A
Q
-
T
A
E
Q
L
K
A
T
T
A
N
G
D
T
A
L
H
L
A
A
R
R
R
D
V
D
M
V
R
I
L
V
D
Y
G
T
N
-
V
D
---------------------------------------
T
Q
N
G
E
G
Q
T
P
L
H
I
A
A
A
E
G
D
E
A
L
L
K
Y
F
Y
G
V
R
A
S
A
--
S
I
A
D
N
Q
D
R
T
P
M
H
L
A
A
E
N
G
H
A
H
V
I
E
I
L
A
D
K
F
K
A
S
I
F
E
R
T
K
D
G
S
T
L
M
H
I
A
S
L
N
G
H
A
E
CATMLFKKGVYLH
M
P
-------
N
K
D
G
A
R
S
I
H
T
A
A
A
Y
G
H
T
G
I
I
N
T
L
L
Q
K
-
G
E
K
-------
V
D
V
T
T
N
D
N
Y
T
A
L
H
I
A
V
E
S
A
K
P
A
V
V
E
T
L
L
G
F
G
A
D
V
H
V
R
G
G
K
L
R
E
T
P
L
H
I
A
A
R
V
K
D
G
D
R
C
A
L
M
L
L
K
S
G
A
S
P
N
--------
L
T
T
D
D
C
L
T
P
V
H
V
A
A
R
H
G
N
L
A
T
L
M
Q
L
L
E
D
E
G
D
P
L
Y
K
S
N
T
-
G
E
T
P
L
H
M
A
C
R
A
C
H
P
----
D
IVR
H
L
I
-----------------------------------------
E
TVKEKHGPDKATTYINSV
N
E
D
G
A
TALHYTCQITKEEVKIPESDKQIVRMLLENGADVTLQTKTALET
A
-
F
H
Y
C
A
V
A
G
N
N
D
V
L
M
E
M
I
S
H
M
N
P
T
DIQKAM----
N
R
Q
S
S
V
G
W
T
P
L
L
I
A
C
H
R
G
---------
H
M
E
L
V
N
N
L
L
A
N
H
A
R
V
D
V
F
----------------------------------------
D
T
E
G
R
S
A
L
H
L
A
A
E
R
G
Y
L
H
V
C
D
A
L
L
T
N
K
A
F
I
N
S
K
S
R
V
GRTALHLAAMNGFTHLVKFLIKDHNAVIDILTLR
K
Q
T
P
L
H
L
A
A
A
S
G
Q
M
E
V
C
Q
L
L
L
E
L
G
A
N
I
D
A
T
D
D
L
G
Q
K
P
I
H
V
A
A
Q
NNYS
E
V
A
K
L
F
L
Q
Q
H
P
S
LVN-
A
T
S
K
D
G
N
T
C
A
H
I
A
A
M
Q
G
S
V
K
V
I
E
E
L
M
K
F
-
D
-
R
S
G
V
IS
A
R
N
K
L
T
D
A
T
P
L
Q
L
A
A
E
G
G
H
A
D
V
V
K
A
L
V
R
A
G
A
S
-
C
T
E
E
N
K
A
G
F
T
A
------------------------------------
V
H
L
A
A
Q
N
G
H
G
Q
V
L
D
--------------------
V
L
K
S
T
N
S
L
R
I
N
S
K
K
L
G
L
T
P
L
H
V
A
A
Y
Y
G
Q
A
D
T
V
R
E
L
L
T
S
V
P
A
T
V
KSETPTGQSLFGD
L
G
T
E
S
G
M
T
P
L
H
L
A
A
-
F
S
G
N
E
N
V
V
R
L
L
L
NSAGVQVDAATIEN-----------
G
Y
N
P
L
H
L
A
C
F
G
G
H
M
S
V
V
G
L
L
L
S
R
S
-
A
E
L
L
Q
-
S
Q
D
R
N
G
R
T
G
L
H
I
A
A
M
H
G
H
I
Q
M
V
E
I
L
L
G
Q
G
A
E
-
I
N
A
T
D
R
N
G
W
T
P
L
H
C
A
A
K
A
G
H
L
E
V
V
K
L
L
C
E
A
G
A
S
P
K
S
E
T
N
Y
G
C
A
A
I
W
F
A
A
S
E
G
H
N
E
V
L
R
Y
L
M
N
K
E
H
D
T
Y
G
L
M
E
D
K
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
46.03
100%
-60
- C1 -
-
5DCZ
1
?
A:
[17-226]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
I
L
I
D
L
S
P
D
D
K
E
F
Q
S
V
E
E
E
M
Q
S
T
V
R
E
H
R
D
G
G
H
A
G
G
I
F
N
R
Y
N
I
L
K
I
Q
K
V
C
N
K
K
L
W
E
R
Y
T
H
R
R
K
E
V
S
E
E
N
H
N
H
A
N
E
R
M
L
F
H
G
S
P
F
V
N
A
I
I
H
K
G
F
D
E
R
H
A
Y
I
G
G
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
V
H
K
D
R
S
C
Y
I
C
H
R
Q
L
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
-----
A
H
S
P
P
G
H
H
S
V
T
G
R
P
--
N
G
L
A
L
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
R
P
E
-----
5
PsiBlast_PDB
45.89
96%
-65
- C1 -
-
3KR7
2
A:
[30-239]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
I
L
I
D
L
S
P
D
D
K
E
F
Q
S
V
E
E
E
M
Q
S
T
V
R
E
H
R
D
G
G
H
A
G
G
I
F
N
R
Y
N
I
L
K
I
Q
K
V
C
N
K
K
L
W
E
R
Y
T
H
R
R
K
E
V
S
E
E
N
H
N
H
A
N
E
R
M
L
F
H
G
S
P
F
V
N
A
I
I
H
K
G
F
D
E
R
H
A
Y
I
G
G
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
V
H
K
D
R
S
C
Y
I
C
H
R
Q
L
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
A
M
-
M
A
H
S
P
P
G
H
H
S
V
T
G
R
P
S
V
N
G
L
A
L
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
R
P
E
-----
36
HHSearch
45.84
96%
-64
- C1 -
-
4PNL
6
?
C:
[16-223]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
L
Y
F
Q
G
S
P
D
D
K
E
F
Q
S
V
E
E
E
M
Q
S
T
V
R
E
H
R
D
G
G
H
A
G
G
I
F
N
R
Y
N
I
L
K
I
Q
K
V
C
N
K
K
L
W
E
R
Y
T
H
R
R
K
E
V
S
E
E
N
H
N
H
A
N
E
R
M
L
F
H
G
S
P
F
V
N
A
I
I
H
K
G
F
D
E
R
H
A
Y
I
G
G
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
V
H
K
D
R
S
C
Y
I
C
H
R
Q
L
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
A
M
K
M
A
H
S
P
P
G
H
H
S
V
T
G
R
P
S
V
N
G
L
A
L
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
R
P
------
2
PsiBlast_PDB
45.58
82%
-
- C2 -
-
3UTM
-
TNKS1_MOUSE
A:
[316-635]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
S
A
K
A
V
-------------
L
T
-------
G
E
Y
K
K
D
E
L
L
E
A
A
R
S
G
N
E
E
K
L
M
A
L
L
T
P
L
N
V
N
-------
C
H
A
S
D
G
R
K
S
T
P
L
H
L
A
A
G
Y
N
R
V
R
I
V
Q
L
L
L
Q
H
G
A
D
V
H
A
K
D
K
-
G
G
L
V
P
L
H
N
A
C
S
Y
G
H
-
Y
E
V
T
E
L
L
L
K
H
G
A
C
V
N
--------
A
M
D
L
W
Q
F
T
P
L
H
E
A
A
S
K
N
R
V
E
V
C
S
L
L
L
S
H
G
A
D
P
T
L
V
N
C
H
-
G
K
S
A
V
D
M
A
P
T
P
E
L
R
----
E
---
R
L
T
-----------------------------------------
Y
------------------
E
F
K
G
H
--------------------------------------------
S
-
L
L
Q
A
A
R
E
A
D
L
A
K
V
K
K
T
L
A
L
E
I
I
N
----------
F
K
Q
P
Q
S
H
E
T
A
L
H
C
A
V
A
S
L
------
H
P
K
R
K
Q
V
A
E
L
L
L
R
K
G
A
N
V
N
E
K
----------------------------------------
N
K
D
F
M
T
P
L
H
V
A
A
E
R
A
H
N
D
V
M
E
V
L
H
K
H
G
A
K
M
N
A
L
D
S
L
----------------------------------
G
Q
T
A
L
H
R
A
A
L
A
G
H
L
Q
T
C
R
L
L
L
S
Y
G
S
D
P
S
I
I
S
L
Q
G
F
T
A
A
Q
M
G
N
E
----
A
V
Q
Q
I
L
S
E
-
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
45.56
42%
-60
- C2 -
-
5LEB
-
?
A:
[15-472]
------------------------------------------------------------
G
K
K
L
L
E
A
A
R
A
G
Q
D
D
E
V
R
I
L
L
A
N
G
A
D
-
V
N
---------------------------------------
T
A
D
E
T
G
F
T
P
L
H
L
A
A
W
E
G
H
L
G
I
V
E
V
L
L
K
N
G
A
D
V
--
N
A
N
D
E
R
G
H
T
P
L
H
L
A
A
Y
T
G
H
L
E
I
V
E
V
L
L
K
N
G
-
A
G
V
N
A
T
---------------------------------------------------------------------------------
D
V
I
G
T
A
P
L
H
L
A
A
M
W
G
H
L
E
I
V
E
V
L
L
K
N
G
A
D
V
F
A
Q
D
K
-
F
G
K
T
P
F
D
L
A
R
D
N
G
N
-
E
W
I
A
K
L
L
L
A
A
---------------------
A
L
L
E
A
A
R
Q
G
Q
R
D
R
V
E
K
L
M
A
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
A
D
V
N
T
A
----------------------------------------
D
E
T
G
F
T
P
L
H
L
A
A
W
E
G
H
L
G
I
V
E
V
L
L
K
N
G
A
D
V
N
A
N
D
E
R
----------------------------------
G
H
T
P
L
H
L
A
A
Y
T
G
H
L
E
I
V
E
V
L
L
K
N
G
A
G
V
N
A
T
D
-------------------------------------------------------------------------
V
I
G
T
A
P
L
H
L
A
A
M
W
G
H
L
E
I
V
E
V
L
L
K
N
G
A
D
-
V
F
A
Q
D
K
F
G
K
T
P
------------------------------------
F
D
L
A
R
D
N
G
N
E
W
I
A
K
L
L
L
A
A
A
L
L
E
A
A
R
Q
GQ
R
D
R
V
E
K
L
M
A
N
G
A
D
V
N
T
A
D
E
T
G
F
T
P
L
H
L
A
A
W
E
G
H
L
G
I
V
E
V
L
L
K
N
G
A
D
V
N
-------------
A
N
D
E
-----------------------------------------------------------------------------------
R
G
H
T
P
L
H
L
A
A
Y
T
G
H
L
E
I
V
E
V
L
L
K
N
G
A
G
-
V
N
A
T
D
V
I
G
T
A
P
L
H
L
A
A
M
W
G
H
L
E
I
V
E
V
L
L
K
N
G
A
D
V
N
A
Q
D
K
F
G
K
T
P
F
D
L
A
I
D
N
G
N
E
D
I
A
E
V
L
Q
K
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
45.41
96%
-66
- C1 -
-
3P0P
1
TNKS2_HUMAN
A:
[30-239]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
I
L
I
D
L
S
P
D
D
K
E
F
Q
S
V
E
E
E
M
Q
S
T
V
R
E
H
R
D
G
G
H
A
G
G
I
F
N
R
Y
N
I
L
K
I
Q
K
V
C
N
K
K
L
W
E
R
Y
T
H
R
R
K
E
V
S
E
E
N
H
N
H
A
N
E
R
M
L
F
H
G
S
P
F
V
N
A
I
I
H
K
G
F
D
E
R
H
A
Y
I
G
G
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
V
H
K
D
R
S
C
Y
I
C
H
R
Q
L
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
----
A
H
S
P
P
G
H
H
S
V
T
G
R
P
S
V
N
G
L
A
L
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
R
P
E
-----
20
PsiBlast_PDB
45.39
96%
-68
- C1 -
-
4BU5
3
TNKS2_HUMAN
A:
[30-239]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
I
L
I
D
L
S
P
D
D
K
E
F
Q
S
V
E
E
E
M
Q
S
T
V
R
E
H
R
D
G
G
H
A
G
G
I
F
N
R
Y
N
I
L
K
I
Q
K
V
C
N
K
K
L
W
E
R
Y
T
H
R
R
K
E
V
S
E
E
N
H
N
H
A
N
E
R
M
L
F
H
G
S
P
F
V
N
A
I
I
H
K
G
F
D
E
R
H
A
Y
I
G
G
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
V
H
K
D
R
S
C
Y
I
C
H
R
Q
L
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
A
M
--
A
H
S
P
P
G
H
H
S
V
T
G
R
P
S
V
N
G
L
A
L
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
R
P
E
-----
22
Fugue
45.20
96%
-267
- C1 -
-
5JRT
-
TNKS2_HUMAN
A:
[11-74]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
F
S
I
T
Q
F
V
R
N
L
G
L
E
H
L
M
D
I
F
E
R
E
Q
I
T
L
R
V
L
V
E
M
G
H
K
E
L
K
E
I
G
I
N
A
Y
G
H
R
E
K
L
I
K
G
V
E
R
L
I
S
G
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
Fugue
45.11
96%
-56
- C1 -
-
4HYF
2
TNKS2_HUMAN
A:
[14-240]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
E
N
L
Y
F
Q
S
M
L
N
T
S
G
S
G
T
I
L
I
D
L
S
P
D
D
K
E
F
Q
S
V
E
E
E
M
Q
S
T
V
R
E
H
R
D
G
G
H
A
G
G
I
F
N
R
Y
N
I
L
K
I
Q
K
V
C
N
K
K
L
W
E
R
Y
T
H
R
R
K
E
V
S
E
E
N
H
N
H
A
N
E
R
M
L
F
H
G
S
P
F
V
N
A
I
I
H
K
G
F
D
E
R
H
A
Y
I
G
G
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
V
H
K
D
R
S
C
Y
I
C
H
R
Q
L
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
A
M
K
M
A
H
S
P
P
G
H
H
S
V
T
G
R
P
S
V
N
G
L
A
L
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
R
P
E
G
----
16
PsiBlast_PDB
45.11
96%
-56
- C1 -
-
4HYF
2
TNKS2_HUMAN
A:
[14-240]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
E
N
L
Y
F
Q
S
M
L
N
T
S
G
S
G
T
I
L
I
D
L
S
P
D
D
K
E
F
Q
S
V
E
E
E
M
Q
S
T
V
R
E
H
R
D
G
G
H
A
G
G
I
F
N
R
Y
N
I
L
K
I
Q
K
V
C
N
K
K
L
W
E
R
Y
T
H
R
R
K
E
V
S
E
E
N
H
N
H
A
N
E
R
M
L
F
H
G
S
P
F
V
N
A
I
I
H
K
G
F
D
E
R
H
A
Y
I
G
G
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
V
H
K
D
R
S
C
Y
I
C
H
R
Q
L
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
A
M
K
M
A
H
S
P
P
G
H
H
S
V
T
G
R
P
S
V
N
G
L
A
L
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
R
P
E
G
----
44
HHSearch
44.90
35%
-74
- C2 -
-
5Y4F
-
ANK2_HUMAN
A:
[2-382]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
T
P
I
H
V
A
A
F
M
G
H
-
L
N
I
V
L
L
L
L
Q
N
G
A
S
P
D
--------
V
T
N
I
R
G
E
T
A
L
H
M
A
A
R
A
G
Q
V
E
V
V
R
C
L
L
R
N
G
A
L
V
D
A
R
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
E
E
Q
T
P
L
H
I
A
S
R
L
G
---------
K
T
E
I
V
Q
L
L
L
Q
H
M
A
H
P
D
A
A
----------------------------------------
T
T
N
G
Y
T
P
L
H
I
S
A
R
E
G
Q
V
D
V
A
S
V
L
L
E
A
G
A
A
H
S
L
A
T
K
K
----------------------------------
G
F
T
P
L
H
V
A
A
K
Y
G
S
L
D
V
A
K
L
L
L
Q
R
R
A
A
A
D
S
A
-------------------------------------------------------------------------
G
K
N
G
L
T
P
L
H
V
A
A
H
Y
D
N
Q
K
V
A
L
L
L
L
E
K
G
A
S
-
P
H
A
T
A
K
N
G
Y
T
P
------------------------------------
L
H
I
A
A
K
K
N
Q
M
Q
I
A
S
--------------------
T
L
L
N
Y
G
A
E
T
N
I
V
T
K
Q
G
V
T
P
L
H
L
A
S
Q
E
G
H
T
D
M
V
T
L
L
L
D
K
G
A
N
I
H
-------------
M
S
T
K
S
-----------------------------------------------------------------------------------
G
L
T
S
L
H
L
A
A
Q
E
D
K
V
N
V
A
D
I
L
T
K
H
G
A
D
-
Q
D
A
H
T
K
L
G
Y
T
P
L
I
V
A
C
H
Y
G
N
V
K
M
V
N
F
L
L
K
Q
G
A
N
V
N
A
K
T
K
N
G
Y
T
P
L
H
Q
A
A
Q
Q
G
H
T
H
I
I
N
V
L
L
Q
H
G
A
K
P
N
A
T
T
A
N
G
N
T
A
L
A
I
A
K
R
L
G
Y
I
S
V
V
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
44.87
96%
-62
- C1 -
-
4BU3
2
TNKS2_HUMAN
A:
[30-239]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
I
L
I
D
L
S
P
D
D
K
E
F
Q
S
V
E
E
E
M
Q
S
T
V
R
E
H
R
D
G
G
H
A
G
G
I
F
N
R
Y
N
I
L
K
I
Q
K
V
C
N
K
K
L
W
E
R
Y
T
H
R
R
K
E
V
S
E
E
N
H
N
H
A
N
E
R
M
L
F
H
G
S
P
F
V
N
A
I
I
H
K
G
F
D
E
R
H
A
Y
I
G
G
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
V
H
K
D
R
S
C
Y
I
C
H
R
Q
L
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
A
M
--
A
H
S
P
P
G
H
H
S
V
T
G
R
P
S
V
N
G
L
A
L
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
R
P
E
-----
11
PsiBlast_PDB
44.86
96%
-66
- C1 -
-
3U9H
3
TNKS2_HUMAN
A:
[30-239]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
I
L
I
D
L
S
P
D
D
K
E
F
Q
S
V
E
E
E
M
Q
S
T
V
R
E
H
R
D
G
G
H
A
G
G
I
F
N
R
Y
N
I
L
K
I
Q
K
V
C
N
K
K
L
W
E
R
Y
T
H
R
R
K
E
V
S
E
E
N
H
N
H
A
N
E
R
M
L
F
H
G
S
P
F
V
N
A
I
I
H
K
G
F
D
E
R
H
A
Y
I
G
G
M
F
G
A
G
I
Y
F
A
E
N
S
S
K
S
N
Q
Y
V
Y
G
I
G
G
G
T
G
C
P
V
H
K
D
R
S
C
Y
I
C
H
R
Q
L
L
F
C
R
V
T
L
G
K
S
F
L
Q
F
S
A
M
--
A
H
S
P
P
G
H
H
S
V
T
G
R
P
S
V
N
G
L
A
L
A
E
Y
V
I
Y
R
G
E
Q
A
Y
P
E
Y
L
I
T
Y
Q
I
M
R
P
E
-----