@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr0006: (2017-12-13 )
MVTLLDLFSENDQIKKWHQNLTDKKRQLILGLSTSTKALAIASSLEKEDRIVLLTSTYGEAEGLVSDLISILGEELVYPFLVDDAPMVEFLMSSQEKIISRVEALRFLTDSSKKGILVCNIAASRLILPSPNAFKDSIVKISVGEEYDQHAFIHQLKENGYRKVTQVQTQGEFSLRGDILDIFEISQLEPCRIEFFGDEIDGIRSFEVETQLSKENKTELTIFPASDMLLREKDYQRGQSALEKQISKTLSPILKSYLEEILSSFHQKQSHADSRKFLSLCYDKTWTVFDYIEKDTPIFFDDYQKLMNQYEVFERELAQYFTEELQNSKAFSDMQYFSDIEQIYKKQSPVTFFSNLQKGLGNLKFDKIYQFNQYPMQEFFNQFSFLKEEIERYKKMDYTIILQSSNSMGSKTLEDMLEEYQIKLDSRDKTSICKESVNLIEGNLRHGFHFVDEKILLITEHEIFQKKLKRRFRRQHVSNAERLKDYNELEKGDYVVHHIHGIGQYLGIETIEIKEIHRDYVSVQYQNGDQISIPVEQIHLLSKYISSDGKAPKLNKLNDGHFKKAKQKVKNQVEDIADDLIKLYSERSQLKGFAFSADDDDQDAFDDAFPYVETDDQLRSIEEIKRDMQASQPMDRLLVGDVGFGKTEVAMRAAFKAVNDHKQVVILVPTTVLAQQHYTNFKERFQNFAVNVDVLSRFRSKKEQTATLEKLKNGQVDILIGTHRVLSKDVVFADLGLMIIDEEQRFGVKHKETLKELKKQVDVLTLTATPIPRTLHMSMLGIRDLSVIETPPTNRYPVQTYVLEKNDSVIRDAVLREMERGGQGYYLYNKVDTIVQKVSELQELIPEASIGYVHGRMSEVQLENTLLDFIEGQYDILVTTTIIETGVDIPNANTLFIENADHMGLSTLYQLRGRVGRSNRIAYAYLMYRPEKSISEVSEKRLEAIKGFTELGSGFKIAMRDLSIRGAGNLLGKSQSGFIDSVGFELYSQLLEEAIAKRNGNANANTRTKGNAELILQIDAYLPDTYISDQRHKIEIYKKIRQIDNRVNYEELQEELIDRFGEYPDVVAYLLEIGLVKSYLDKVFVQRVERKDNKITIQFEKVTQRLFLAQDYFKALSVTNLKAGIAENKGLMELVFDVQNKKDYEILEGLLIFGESLLEIKESKEKNSI
Atome Classification :
(20 SA)
.........10........20-........30-........40.......-.50........60........70........80.-------------.......90........100.......110.......--120.......130..-.....140.......150.......160.......170.......180.....-..190.......200.......210.......220-----..---.....230.-----......240.......250----------........260..--.....270.......280.-----.-...-..290.......300---.........310.......320.....----.--.330.........340....--...350.....----....360.......370--------........--380.......390.-.-.....400.......410.......420---.....-.-.----430----.....--....440.......450.......460.......470---.--.--.--.....480----.........490--------.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610........620.......630.......640.......650.......660-----.........670.......680......-.690-.---........700.......710-........720.......----------730.......740..----------....---.---750---.----.---..---.---..-------..760.......770.......780.....--....790---.----.---......800--.--...--.--.---.----810......---.820.......830........840----..-..-.-...850.......860.......870........880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980......--.990...--.--...1000..--....1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130.......1140......1150......1160......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
V
T
L
L
D
L
FSE
N
D
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I
K
K
W
H
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A
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SLEKE-D
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TSTYG
E
A
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L
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D
L
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LV-------------DD
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M
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G
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--NIAA
S
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ILPSPNAF-KD
S
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SVGEEY
D
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ENG
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TQGE
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P
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FGDEIDG
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QLSKENK
T
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-----FP---ASD
M
L
L
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W
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F
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A
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SKEKNSI
36
Fugue
65.56
34%
4
- C1 -
-
2EYQ
3
MFD_ECOLI
A:
[5-1150]
-----------
P
E
Q
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E
E
----
N
A
I
1
PsiBlast_PDB
61.37
36%
24
- C1 -
-
2EYQ
3
MFD_ECOLI
A:
[19-1092]
---------------------------
Q
R
L
L
G
E
L
T
G
A
A
C
A
T
L
V
A
E
I
A
E
R
H
-
A
G
P
V
V
L
I
A
P
D
M
Q
N
A
L
R
L
H
D
E
I
S
Q
F
T
D
Q
M
V
M
-
N
L
A
-------------
D
W
E
T
L
P
Y
D
S
F
S
P
H
Q
D
I
I
S
S
R
L
S
T
L
Y
Q
L
P
T
M
Q
R
G
V
L
I
V
P
V
N
T
L
M
Q
R
V
---
C
P
H
S
F
L
H
G
H
A
L
V
M
K
K
G
Q
R
L
S
R
D
A
L
R
T
Q
L
D
S
A
G
Y
R
H
V
D
Q
V
M
E
H
G
E
Y
A
T
R
G
A
L
L
D
L
F
P
M
G
S
-
E
L
P
Y
R
L
D
F
F
D
D
E
I
D
S
L
R
V
F
D
V
D
S
Q
R
T
L
E
E
V
E
A
I
N
L
L
P
AHE
F
P
TD
K
A
A
I
E
L
F
R
S
Q
W
R
D
T
F
E
V
K
R
D
P
E
H
I
Y
Q
Q
V
S
K
G
T
L
-----------
P
A
G
I
E
Y
W
Q
P
L
F
F
S
EP
L
P
P
L
F
S
Y
F
P
A
N
T
L
L
V
N
T
G
D
-----
L
-
E
-
T
-
S
A
E
R
F
Q
A
D
T
L
A
R
F
E
N
R
GV
D
P
M
R
P
L
L
P
P
Q
S
L
W
L
R
------
V
D
E
L
-------------
F
S
E
L
K
N
W
P
R
V
-
Q
L
K
T
E
--
H
L
P
T
------------
K
A
A
N
A
N
L
G
F
Q
K
L
P
D
L
---------
A
V
Q
A
Q
Q
K
----
A
P
L
D
A
L
R
K
F
L
E
T
F
-----
D
G
P
V
V
F
S
V
E
S
E
G
R
R
E
A
L
G
E
L
L
A
R
I
K
I
A
P
Q
R
I
M
R
L
-
D
-
E
----
A
------
S
--
D
R
--
G
R
Y
L
M
I
G
A
A
E
H
G
F
V
D
T
V
R
N
L
A
L
I
C
E
S
D
L
L
G
E
R
V
A
R
R
----
R
--
Q
DS
R
--
R
T
I
N
P
D
------
T
L
I
R
N
L
A
E
L
H
I
G
--------
Q
P
V
V
H
L
E
H
G
V
G
R
Y
A
G
M
T
T
L
E
A
G
G
I
T
G
E
Y
L
M
L
T
Y
A
N
D
A
K
L
Y
V
P
V
S
S
L
H
L
I
S
R
Y
A
G
G
A
E
E
N
A
P
L
H
K
L
G
G
D
A
W
S
R
A
R
Q
K
A
A
E
K
V
R
D
V
A
A
E
L
L
D
I
Y
A
Q
R
A
A
K
E
G
F
A
F
K
H
D
R
E
Q
Y
Q
L
F
C
D
S
F
P
F
-
E
T
T
P
D
Q
A
Q
A
I
N
A
V
L
S
D
M
C
Q
P
L
A
M
D
R
L
V
C
G
D
V
G
F
G
K
T
E
V
A
M
R
A
A
F
L
A
V
D
N
-------
H
K
Q
V
A
V
L
V
P
T
T
L
L
A
Q
Q
H
Y
D
N
F
R
D
R
F
A
N
W
-
P
V
---
R
---
I
E
M
I
S
R
F
R
S
A
K
E
Q
T
Q
I
L
A
E
V
--
A
E
G
K
I
D
I
L
I
G
T
H
K
L
L
Q
S
D
----------
V
K
F
K
D
L
G
L
L
I
V
D
E
E
H
----------
R
F
G
V
---
R
---
H
-----
K
----
E
---
R
I
---
K
---
A
M
-------
R
A
N
V
D
I
L
T
L
T
A
T
P
I
P
R
T
L
N
M
A
M
S
--
G
M
R
D
L
--
S
I
I
A
T
P
----
P
----
A
---
R
R
L
A
V
K
T
F
V
--
R
--
E
Y
D
--
S
--
M
---
V
----
V
R
E
A
I
L
R
E
I
---
L
R
G
G
Q
V
Y
Y
L
Y
N
D
-
V
E
N
I
Q
K
A
A
E
R
L
-----
A
E
-
L
V
-
P
-
E
A
R
I
A
I
G
H
G
Q
M
R
E
R
E
L
E
R
V
M
N
D
F
H
H
-
Q
R
F
N
V
L
V
C
T
T
I
I
E
T
G
I
D
I
P
T
A
N
T
I
I
I
E
R
A
D
H
F
G
L
A
Q
L
H
Q
L
R
G
R
V
G
R
S
H
H
Q
A
Y
A
W
L
L
T
P
H
P
K
A
M
T
T
D
A
Q
K
R
L
E
A
I
A
S
L
E
D
L
G
A
G
F
A
L
A
T
H
D
L
E
I
R
G
A
G
E
L
L
G
E
E
Q
S
G
S
M
E
T
I
G
F
S
L
Y
M
--
E
L
L
E
N
A
V
D
A
L
--
K
A
G
R
E
P
S
L
E
--
D
L
T
S
Q
Q
T
E
V
E
L
R
M
P
S
L
L
P
D
D
F
I
P
D
V
N
T
R
L
S
F
Y
K
R
I
A
S
A
K
T
E
N
E
L
E
E
I
K
V
E
L
I
D
R
F
G
L
L
P
D
P
A
R
T
L
L
D
I
A
R
L
R
Q
Q
A
Q
K
L
G
I
R
K
L
E
G
N
E
K
G
G
V
I
E
F
-----------------------------------------------------------------------
21
PsiBlast_CBE
60.71
36%
27
- C1 -
-
2EYQ
3
MFD_ECOLI
B:
[19-1092]
---------------------------
Q
R
L
L
G
E
L
T
G
A
A
C
A
T
L
V
A
E
I
A
E
R
H
-
A
G
P
V
V
L
I
A
P
D
M
Q
N
A
L
R
L
H
D
E
I
S
Q
F
T
D
Q
M
V
M
-
N
L
A
-------------
D
W
E
T
L
P
Y
D
S
F
S
P
H
Q
D
I
I
S
S
R
L
S
T
L
Y
Q
L
P
T
M
Q
R
G
V
L
I
V
P
V
N
T
L
M
Q
R
V
---
C
P
H
S
F
L
H
G
H
A
L
V
M
K
K
G
Q
R
L
S
R
D
A
L
R
T
Q
L
D
S
A
G
Y
R
H
V
D
Q
V
M
E
H
G
E
Y
A
T
R
G
A
L
L
D
L
F
P
M
G
S
-
E
L
P
Y
R
L
D
F
F
D
D
E
I
D
S
L
R
V
F
D
V
D
S
Q
R
T
L
E
E
V
E
A
I
N
L
L
P
AHE
F
P
TD
K
A
A
I
E
L
F
R
S
Q
W
R
D
T
F
E
V
K
R
D
P
E
H
I
Y
Q
Q
V
S
K
G
T
L
-----------
P
A
G
I
E
Y
W
Q
P
L
F
F
S
EP
L
P
P
L
F
S
Y
F
P
A
N
T
L
L
V
N
T
G
D
-----
L
-
E
-
T
-
S
A
E
R
F
Q
A
D
T
L
A
R
F
E
NRGV
D
P
M
R
P
L
L
P
P
Q
S
L
W
L
R
------
V
D
E
L
-------------
F
S
E
L
K
N
W
P
R
V
-
Q
L
K
T
E
--
H
L
P
T
------------
K
A
A
N
A
N
L
G
F
Q
K
L
P
D
L
---------
A
V
Q
A
Q
Q
K
----
A
P
L
D
A
L
R
K
F
L
E
T
F
-----
D
G
P
V
V
F
S
V
E
S
E
G
R
R
E
A
L
G
E
L
L
A
R
I
K
I
A
P
Q
R
I
M
R
L
-
D
-
E
----
A
------
S
--
D
R
--
G
R
Y
L
M
I
G
A
A
E
H
G
F
V
D
T
V
R
N
L
A
L
I
C
E
S
D
L
L
G
E
R
V
A
R
R
----
R
--
Q
DS
R
--
R
T
I
N
P
D
------
T
L
I
R
N
L
A
E
L
H
I
G
--------
Q
P
V
V
H
L
E
H
G
V
G
R
Y
A
G
M
T
T
L
E
A
G
G
I
T
G
E
Y
L
M
L
T
Y
A
N
D
A
K
L
Y
V
P
V
S
S
L
H
L
I
S
R
Y
A
G
G
A
E
E
N
A
P
L
H
K
L
G
G
D
A
W
S
R
A
R
Q
K
A
A
E
K
V
R
D
V
A
A
E
L
L
D
I
Y
A
Q
R
A
A
K
E
G
F
A
F
K
H
D
R
E
Q
Y
Q
L
F
C
D
S
F
P
F
-
E
T
T
P
D
Q
A
Q
A
I
N
A
V
L
S
D
M
C
Q
P
L
A
M
D
R
L
V
C
G
D
V
G
F
G
K
T
E
V
A
M
R
A
A
F
L
A
V
D
N
-------
H
K
Q
V
A
V
L
V
P
T
T
L
L
A
Q
Q
H
Y
D
N
F
R
D
R
F
A
N
W
-
P
V
---
R
---
I
E
M
I
S
R
F
R
S
A
K
E
Q
T
Q
I
L
A
E
V
--
A
E
G
K
I
D
I
L
I
G
T
H
K
L
L
Q
S
D
----------
V
K
F
K
D
L
G
L
L
I
V
D
E
E
H
----------
R
F
G
V
---
R
---
H
-----
K
----
E
---
R
I
---
K
---
A
M
-------
R
A
N
V
D
I
L
T
L
T
A
T
P
I
P
R
T
L
N
M
A
M
S
--
G
M
R
D
L
--
S
I
I
A
T
P
----
P
----
A
---
R
R
L
A
V
K
T
F
V
--
R
--
E
Y
D
--
S
--
M
---
V
----
V
R
E
A
I
L
R
E
I
---
L
R
G
G
Q
V
Y
Y
L
Y
N
D
-
V
E
N
I
Q
K
A
A
E
R
L
-----
A
E
-
L
V
-
P
-
E
A
R
I
A
I
G
H
G
Q
M
R
E
R
E
L
E
R
V
M
N
D
F
H
H
-
Q
R
F
N
V
L
V
C
T
T
I
I
E
T
G
I
D
I
P
T
A
N
T
I
I
I
E
R
A
D
H
F
G
L
A
Q
L
H
Q
L
R
G
R
V
G
R
S
H
H
Q
A
Y
A
W
L
L
T
P
H
P
K
A
M
T
T
D
A
Q
K
R
L
E
A
I
A
S
L
E
D
L
G
A
G
F
A
L
A
T
H
D
L
E
I
R
G
A
G
E
L
L
G
E
E
Q
S
G
S
M
E
T
I
G
F
S
L
Y
M
--
E
L
L
E
N
A
V
D
A
L
--
K
A
G
R
E
P
S
L
E
--
D
L
T
S
Q
Q
T
E
V
E
L
R
M
P
S
L
L
P
D
D
F
I
P
D
V
N
T
R
L
S
F
Y
K
R
I
A
S
A
K
T
E
N
E
L
E
E
I
K
V
E
L
I
D
R
F
G
L
L
P
D
P
A
R
T
L
L
D
I
A
R
L
R
Q
Q
A
Q
K
L
G
I
R
K
L
E
G
N
E
K
G
G
V
I
E
F
-----------------------------------------------------------------------
45
HHSearch
60.29
34%
22
- C1 -
-
2EYQ
3
MFD_ECOLI
A:
[16-1116]
-----------------------
A
G
E
Q
R
L
L
G
E
-
L
T
G
A
A
C
A
T
L
V
A
E
I
A
E
R
H
A
G
P
V
V
L
I
A
P
D
M
Q
N
A
L
R
L
H
D
E
I
S
Q
F
T
D
Q
-
M
V
M
N
L
A
D
-------------
W
E
T
L
P
Y
D
S
F
S
P
H
Q
D
I
I
S
S
R
L
S
T
L
Y
Q
L
P
T
-
M
Q
R
G
V
L
I
V
--
P
V
N
T
L
M
Q
R
V
C
P
H
S
F
L
-
H
G
H
A
L
V
M
K
K
G
Q
R
L
S
R
D
A
L
R
T
Q
L
D
S
A
G
Y
R
H
V
D
Q
V
M
E
H
G
E
Y
A
T
R
G
A
L
L
D
L
F
P
M
G
S
-
E
L
P
Y
R
L
D
F
F
D
D
E
I
D
S
L
R
V
F
D
V
D
S
Q
R
T
L
E
E
V
E
A
I
N
L
-----
L
P
---
A
H
E
F
P
T
D
K
A
-----
A
I
E
L
F
R
S
Q
W
R
D
T
F
E
-----------------
V
K
R
D
P
E
H
I
Y
Q
Q
--
V
S
K
G
T
L
P
A
G
I
E
Y
W
Q
P
L
F
F
S
-----
E
P
L
P
P
-
L
F
S
Y
F
P
A
N
T
L
L
V
-------
N
T
G
D
L
E
T
S
A
E
R
F
Q
A
D
T
L
A
R
F
E
N
R
G
V
D
PM
R
P
L
--
L
P
--
P
Q
S
--
L
W
L
R
V
D
E
L
F
S
E
--
L
K
N
W
P
R
V
Q
L
K
T
----
E
H
L
P
----
T
K
A
A
N
A
N
L
---------
G
F
Q
K
L
P
D
L
AV
Q
A
Q
Q
K
A
P
L
D
A
L
R
K
F
-
L
E
T
F
D
G
P
V
V
F
S
V
E
S
E
G
R
R
E
A
L
G
E
L
L
A
R
I
K
I
---
A
P
Q
R
I
-
M
-
R
----
L
D-----
E
A
S
D
R
--
G
R
Y
L
M
I
G
A
A
E
H
G
F
V
D
T
V
R
N
L
A
L
I
C
E
S
D
L
L
G
E
R
V
A
R
R
----
R
--
Q
--
D
SR
R
T
I
N
P
D
------
T
L
I
R
N
L
A
E
L
H
I
G
--------
Q
P
V
V
H
L
E
H
G
V
G
R
Y
A
G
M
T
T
L
E
A
G
G
I
T
G
E
Y
L
M
L
T
Y
A
N
D
A
K
L
Y
V
P
V
S
S
L
H
L
I
S
R
Y
A
G
G
A
E
E
N
A
P
L
H
K
L
G
G
D
A
W
S
R
A
R
Q
K
A
A
E
K
V
R
D
V
A
A
E
L
L
D
I
Y
A
Q
R
A
A
K
E
G
F
A
F
K
H
D
R
E
Q
Y
Q
L
F
C
D
S
F
P
F
-
E
T
T
P
D
Q
A
Q
A
I
N
A
V
L
S
D
M
C
Q
P
L
A
M
D
R
L
V
C
G
D
V
G
F
G
K
T
E
V
A
M
R
A
A
F
L
A
V
D
N
-------
H
K
Q
V
A
V
L
V
P
T
T
L
L
A
Q
Q
H
Y
D
N
F
R
D
R
F
A
N
W
-
P
V
---
R
---
I
E
M
I
S
R
F
R
S
A
K
E
Q
T
Q
I
L
A
E
V
--
A
E
G
K
I
D
I
L
I
G
T
H
K
L
L
Q
S
D
----------
V
K
F
K
D
L
G
L
L
I
V
D
E
E
H
----------
R
F
G
V
---
R
---
H
-----
K
----
E
---
R
I
---
K
---
A
M
-------
R
A
N
V
D
I
L
T
L
T
A
T
P
I
P
R
T
L
N
M
A
M
S
--
G
M
R
D
L
--
S
I
I
A
T
P
----
P
----
A
---
R
R
L
A
V
K
T
F
V
--
R
--
E
Y
D
--
S
--
M
---
V
----
V
R
E
A
I
L
R
E
I
---
L
R
G
G
Q
V
Y
Y
L
Y
N
D
-
V
E
N
I
Q
K
A
A
E
R
L
-----
A
E
-
L
V
-
P
-
E
A
R
I
A
I
G
H
G
Q
M
R
E
R
E
L
E
R
V
M
N
D
F
H
H
-
Q
R
F
N
V
L
V
C
T
T
I
I
E
T
G
I
D
I
P
T
A
N
T
I
I
I
E
R
A
D
H
F
G
L
A
Q
L
H
Q
L
R
G
R
V
G
R
S
H
H
Q
A
Y
A
W
L
L
T
P
H
P
K
A
M
T
T
D
A
Q
K
R
L
E
A
I
A
S
L
E
D
L
G
A
G
F
A
L
A
T
H
D
L
E
I
R
G
A
G
E
L
L
G
E
E
Q
S
G
S
M
E
T
I
G
F
S
L
Y
M
--
E
L
L
E
N
A
V
--
D
--
A
L
K
A
G
R
E
P
S
LE
D
L
T
S
Q
Q
T
E
V
E
L
R
M
P
S
L
L
P
D
D
F
I
P
D
V
N
T
R
L
S
F
Y
K
R
I
A
S
A
K
T
E
N
E
L
E
E
I
K
V
E
L
I
D
R
F
G
L
L
P
D
P
A
R
T
L
L
D
I
A
R
L
R
Q
Q
A
Q
K
L
G
I
R
K
L
E
G
N
E
K
G
G
V
I
E
F
A
E
K
N
--
H
V
N
P
A
W
L
I
G
L
L
Q
K
Q
P
Q
H
Y
R
L
---------------------------------------------
2
PsiBlast_PDB
56.65
99%
-167
- C3 -
-
2QSR
-
?
A:
[1007-1165]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
K
G
N
A
E
L
I
L
Q
I
D
A
Y
L
P
D
T
Y
I
S
D
Q
R
H
K
I
E
I
Y
K
K
I
R
Q
I
D
N
R
V
N
Y
E
E
L
Q
E
E
L
I
D
R
F
G
E
Y
P
D
V
V
A
Y
L
L
E
I
G
L
V
K
S
Y
L
D
K
V
F
V
Q
R
V
E
R
K
D
N
K
I
T
I
Q
F
E
K
V
T
Q
R
L
F
L
A
Q
D
Y
F
K
A
L
S
V
T
N
L
K
A
G
I
A
E
N
K
G
L
M
-
E
L
V
F
D
V
Q
N
K
K
D
Y
E
I
L
E
G
L
L
I
F
G
E
S
L
L
E
I
K
E
S
K
E
----
59
HHSearch
56.28
100%
-170
- C3 -
-
2QSR
-
?
A:
[1009-1165]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
N
A
E
L
I
L
Q
I
D
A
Y
L
P
D
T
Y
I
S
D
Q
R
H
K
I
E
I
Y
K
K
I
R
Q
I
D
N
R
V
N
Y
E
E
L
Q
E
E
L
I
D
R
F
G
E
Y
P
D
V
V
A
Y
L
L
E
I
G
L
V
K
S
Y
L
D
K
V
F
V
Q
R
V
E
R
K
D
N
K
I
T
I
Q
F
E
K
V
T
Q
R
L
F
L
A
Q
D
Y
F
K
A
L
S
V
T
N
L
K
A
G
I
A
E
N
K
G
L
M
-
E
L
V
F
D
V
Q
N
K
K
D
Y
E
I
L
E
G
L
L
I
F
G
E
S
L
L
E
I
K
E
S
K
E
----
48
HHSearch
55.90
40%
-61
- C1 -
-
1GM5
1
?
A:
[354-740]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
G
K
L
A
E
E
F
I
K
S
L
P
F
-
K
L
T
N
A
Q
K
R
A
H
Q
E
I
R
N
D
M
I
S
E
K
P
M
N
R
L
L
Q
G
D
V
G
S
G
K
T
V
V
A
Q
L
A
I
L
D
N
Y
E
A
-------
G
F
Q
T
A
F
M
V
P
T
S
I
L
A
I
Q
H
Y
R
R
T
V
E
S
F
S
K
F
-
N
I
---
H
---
V
A
L
L
I
G
A
T
T
P
S
E
K
E
K
I
K
S
G
L
--
R
N
G
Q
I
D
V
V
I
G
T
H
A
L
I
Q
E
D
----------
V
H
F
K
N
L
G
L
V
I
I
D
E
Q
H
----------
R
F
--------------------
E
---
A
L
---
M
---
N
K
-------
G
K
M
V
D
T
L
V
M
S
A
T
P
I
P
R
S
M
A
L
A
F
Y
--
G
D
L
D
V
--
T
V
I
D
E
M
----
P
----
P
---
G
R
K
E
V
Q
T
M
L
--
V
--
P
M
D
R-
V
--
N
---
E
----
V
Y
E
F
V
R
Q
E
V
---
M
R
G
G
Q
A
F
I
V
Y
P
L
I-
K
S
A
V
E
M
Y
E
Y
L
-----
S
K
E
V
F
-----
K
L
G
L
M
H
G
R
L
S
Q
E
E
K
D
R
V
M
L
E
F
A
E
-
G
R
Y
D
I
L
V
S
T
T
V
I
E
V
G
I
D
V
P
R
A
N
V
M
V
I
E
N
P
E
R
F
G
L
A
Q
L
H
Q
L
R
G
R
V
G
R
G
G
Q
E
A
Y
C
F
L
V
V
G
D
V
---
G
E
E
A
M
E
R
L
R
F
F
T
L
N
---
T
D
G
F
K
I
A
E
Y
D
L
K
T
R
G
P
G
E
----
K
Q
H
G
L
S
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
Fugue
51.27
96%
-117
* C3 *
-
2QSR
-
?
A:
[1005-1165]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--
L
R
T
K
G
N
A
E
L
I
L
Q
I
D
A
Y
L
P
D
T
Y
I
S
D
Q
R
H
K
I
E
I
Y
K
K
I
R
Q
I
D
N
R
V
N
Y
E
E
L
Q
E
E
L
I
D
R
F
G
E
Y
P
D
V
V
A
Y
L
L
E
I
G
L
V
K
S
Y
L
D
K
V
F
V
Q
R
V
E
R
K
D
N
K
I
T
I
Q
F
E
K
V
T
Q
R
L
F
L
A
Q
D
Y
F
K
A
L
S
V
T
N
L
K
A
G
I
A
E
N
-
K
G
L
M
E
L
V
F
D
V
Q
N
K
K
D
Y
E
I
L
E
G
L
L
I
F
G
E
S
L
L
E
I
K
E
S
K
E
----
3
PsiBlast_PDB
49.99
39%
-40
- C1 -
-
1GM5
1
?
A:
[338-755]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
K
E
R
E
K
H
G
G
I
P
K
K
I
E
G
K
L
A
E
E
F
I
K
S
L
P
F
-
K
L
T
N
A
Q
K
R
A
H
Q
E
I
R
N
D
M
I
S
E
K
P
M
N
R
L
L
Q
G
D
V
G
S
G
K
T
V
V
A
Q
L
A
I
L
D
N
Y
E
A
-------
G
F
Q
T
A
F
M
V
P
T
S
I
L
A
I
Q
H
Y
R
R
T
V
E
S
F
S
K
F
-
N
I
---
H
---
V
A
L
L
I
G
A
T
T
P
S
E
K
E
K
I
K
S
G
L
--
R
N
G
Q
I
D
V
V
I
G
T
H
A
L
I
Q
E
D
----------
V
H
F
K
N
L
G
L
V
I
I
D
E
Q
H
----------
R
F
--------------------
E
---
A
L
---
M
---
N
K
-------
G
K
M
V
D
T
L
V
M
S
A
T
P
I
P
R
S
M
A
L
A
F
Y
--
G
D
L
D
V
--
T
V
I
D
E
M
----
P
----
P
---
G
R
K
E
V
Q
T
-
M
--
L
--
V
P
M
--
D
--
R
---
V
N
E
--
V
Y
E
F
V
R
Q
E
V
---
M
R
G
G
Q
A
F
I
V
Y
P
L
-
I
----
K
S
A
V
E
M
Y
EYLS
K
E
-
V
F
-----
K
L
G
L
M
H
G
R
L
S
Q
E
E
K
D
R
V
M
L
E
F
A
E
-
G
R
Y
D
I
L
V
S
T
T
V
I
E
V
G
I
D
V
P
R
A
N
V
M
V
I
E
N
P
E
R
F
G
L
A
Q
L
H
Q
L
R
G
R
V
G
R
G
G
Q
E
A
Y
C
F
L
V
------
V
G
D
V
G
E
E
A
M
E
R
L
R
F
F
T
L
N
T
D
G
F
K
I
A
E
Y
D
L
K
T
R
G
P
G
E
----
K
Q
H
G
L
S
G
F
K
V
A
D
L
Y
R
DL
K
L
L
E
W
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
Fugue
45.28
18%
-39
- C1 -
-
3HJH
-
MFD_ECOLI
A:
[5-450]
--------------
Y
R
Y
T
L
P
V
-
K
A
G
E
Q
R
L
L
G
E
-
L
T
G
A
A
C
A
T
L
V
A
E
I
A
E
R
H
-
A
G
P
V
V
L
I
A
P
D
M
Q
N
A
L
R
L
H
D
E
I
S
Q
F
T
D
Q
M
V
M
N
L
A
D
-------------
W
E
T
L
P
Y
D
S
F
S
P
H
Q
D
I
I
S
S
R
L
S
T
L
Y
Q
L
P
T
M
-
Q
R
G
V
L
I
V
--
P
V
N
T
L
M
Q
R
V
C
P
H
S
F
L
-
H
G
H
A
L
V
M
K
K
G
Q
R
L
S
R
D
A
L
R
T
Q
L
D
S
A
G
Y
R
H
V
D
Q
V
M
E
H
G
E
Y
A
T
R
G
A
L
L
D
L
F
P
M
G
S
-
E
L
P
Y
R
L
D
F
F
D
D
E
I
D
S
L
R
V
F
D
V
D
S
Q
R
T
L
E
E
V
E
A
I
N
L
-----
L
P
---
A
H
E
F
P
T
D
K
A
-----
A
I
E
L
F
R
S
Q
W
R
D
T
F
E
V
K
R
D
-----------
P
------
E
H
I
Y
Q
Q
--
V
S
K
G
T
L
P
A
G
I
E
Y
W
Q
P
L
F
F
S
-----
E
P
L
P
P
-
L
F
S
Y
F
P
A
N
T
L
L
V
N
-----
T
G
--
D
L
E
T
S
A
E
R
F
Q
A
D
T
L
A
R
F
E
N
R
G
V
D
----
P
M
R
P
L
--
L
P
P
Q
S
L
W
L
R
V
D
E
L
F
S
E
--
L
K
N
W
--
P
R
V
Q
L
----
K
T
E
H
L
P
T
K
A
A
N
A
N
L
G
F
---------
Q
K
L
P
D
L
A
V
--
Q
A
Q
Q
K
A
P
L
D
A
L
R
K
F
L
E
-
T
F
D
G
P
V
V
F
S
V
E
S
E
G
R
R
E
A
L
G
E
L
L
A
R
I
K
I
---
A
P
Q
R
I
-
M
R
L
----
D
------
E
A
S
D
R
--
G
R
Y
L
M
I
G
A
A
E
H
G
F
V
D
T
V
R
N
L
A
L
I
C
E
S
D
L
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
43.00
29%
-100
- C1 -
-
4NL4
1
?
H:
[236-431]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
A
G
I
T
G
S
G
K
T
E
V
Y
L
S
V
L
E
N
V
L
A
Q
-------
G
R
Q
A
L
V
M
V
P
E
I
G
L
T
P
Q
T
I
A
R
F
R
Q
R
F
N
----
A
---
P
---
V
E
V
L
H
S
G
L
N
D
S
E
R
L
S
A
W
L
K
A
--
K
N
G
E
A
A
I
V
I
G
T
R
S
S
L
F
T
P
------------
F
K
D
L
G
V
I
V
I
D
E
E
H
DSSYKQQEGW
R
Y
H
A
---
R
---
D
-----
L
----
A
---
V
W
---
R
---
A
H
-------
S
E
Q
I
P
I
I
L
G
S
A
T
P
A
L
E
T
L
H
N
V
R
Q
--
G
K
Y
R
Q
--
L
T
L
S
K
-----------------
P
A
Q
Q
H
V
--
L
--
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
HHSearch
42.97
19%
37
- C1 -
-
2NMV
3
?
A:
[17-642]
---------
Q
P
K
A
I
E
K
L
V
K
G
I
Q
E
G
K
K
H
Q
T
L
L
G
-
A
T
G
T
G
K
T
F
T
V
S
N
L
I
K
E
V
N
K
P
T
L
V
I
A
H
N
K
T
L
A
G
Q
L
Y
S
E
F
K
E
F
F
P
N
N
A
V
E
Y
F
V
S
YYDYYQ
P
E
A
Y
V
PQ
T
D
T
F
I
E
K
D
A
S
I
N
D
E
I
D
K
L
R
H
S
A
T
S
A
L
F
E
-
R
R
D
V
I
I
I
A
--
S
V
S
C
-
I
Y
G
L
G
S
P
E
E
Y
-
R
E
M
V
V
S
L
R
T
E
M
E
I
E
R
N
E
L
L
R
K
L
V
D
I
Q
Y
A
R
N
D
I
D
F
Q
R
G
T
F
R
V
R
G
D
V
V
E
I
F
P
A
S
R
D
E
H
C
V
R
V
E
F
F
G
D
E
I
E
R
I
R
E
V
D
A
L
T
G
E
I
L
G
D
R
D
H
V
A
I
-----
F
P
---
A
S
H
F
V
T
R
A
E
-----
K
M
E
K
A
I
Q
N
I
E
K
E
L
E
E
Q
L
K
V
M
H
E
N
GK
L
L
E
A
Q
R
L
E
Q
R
T
R
Y
D
L
E
M
--
M
R
E
M
G
F
C
S
G
I
E
N
Y
S
R
H
L
T
L
RPPGS
T
-
P
Y
T
-
L
L
D
Y
F
P
D
D
F
M
I
V
V
-----
D
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V
T
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R
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M
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G
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L
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R
--
L
P
--
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A
L
D
N
R
P
L
R
F
E
E
F
E
K
H
--
M
H
N
I
--
V
Y
V
S
A
----
T
P
G
P
Y
E
I
E
H
T
D
E
M
V
E
Q
I
IRPTGLLD
P
L
I
D
V
R
P
I
--
E
G
Q
I
D
D
L
I
G
E
I
Q
A
R
-
I
-
E
R
N
E
R
V
L
V
T
T
L
T
K
K
M
S
E
D
L
T
D
Y
L
K
E
I
G
I
---
K
V
N
Y
L
H
S
-
E
IK
T
L
E
R
I
E
I
I
R
D
L
R
L
G
KY
D
V
L
V
G
I
N
L
L
R
E
G
L
D
I
P
E
V
S
L
V
A
I
L
D
A
D
K
E
G
F
L
R
S
E
R
S
L
I
Q
T
I
G
R
--
A
--
A
R
N
A
E
G
R
V
I
M
Y
A
D
K
I
T
K
S
M
E
I
A
I
N
E
T
K
R
R
R
E
Q
Q
E
R
F
N
E
E
H
G
I
T
------
P
K
T
I
N
--------------------------------------------
K
K
E
R
Q
K
V
V
E
Q
M
E
H
E
M
K
E
A
A
K
A
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
HHSearch
41.73
18%
-3
- C1 -
-
3HJH
-
MFD_ECOLI
A:
[13-450]
-----------------------
A
G
E
Q
R
L
L
G
E
-
L
T
G
A
A
C
A
T
L
V
A
E
I
A
E
R
H
A
G
P
V
V
L
I
A
P
D
M
Q
N
A
L
R
L
H
D
E
I
S
Q
F
T
D
Q
-
M
V
M
N
L
A
D
-------------
W
E
T
L
P
Y
D
S
F
S
P
H
Q
D
I
I
S
S
R
L
S
T
L
Y
Q
L
P
T
-
M
Q
R
G
V
L
I
V
--
P
V
N
T
L
M
Q
R
V
C
P
H
S
F
L
-
H
G
H
A
L
V
M
K
K
G
Q
R
L
S
R
D
A
L
R
T
Q
L
D
S
A
G
Y
R
H
V
D
Q
V
M
E
H
G
E
Y
A
T
R
G
A
L
L
D
L
F
P
M
G
S
-
E
L
P
Y
R
L
D
F
F
D
D
E
I
D
S
L
R
V
F
D
V
D
S
Q
R
T
L
E
E
V
E
A
I
N
L
-----
L
P
---
A
H
E
F
P
T
D
K
A
-----
A
I
E
L
F
R
S
Q
W
R
D
T
F
E
-----------------
V
K
R
D
P
E
H
I
Y
Q
Q
--
V
S
K
G
T
L
P
A
G
I
E
Y
W
Q
P
L
F
F
S
-----
E
P
L
P
P
-
L
F
S
Y
F
P
A
N
T
L
L
V
N
-------
T
G
D
L
E
T
S
A
E
R
F
Q
A
D
T
L
A
R
F
E
N
R
G
V
D
PM
R
P
L
--
L
P
--
P
Q
S
--
L
W
L
R
V
D
E
L
F
S
E
--
L
K
N
W
P
R
V
Q
L
K
T
----
E
H
L
P
----
T
K
A
A
N
A
N
L
---------
G
F
Q
K
L
P
D
L
AV
Q
A
Q
Q
K
A
P
L
D
A
L
R
K
F
-
L
E
T
F
D
G
P
V
V
F
S
V
E
S
E
G
R
R
E
A
L
G
E
L
L
A
R
I
K
I
---
A
P
Q
R
I
-
M
-
R
----
L
D-----
E
A
S
D
R
--
G
R
Y
L
M
I
G
A
A
E
H
G
F
V
D
T
V
R
N
L
A
L
I
C
E
S
D
L
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
HHSearch
40.91
20%
-8
- C1 -
-
1OYW
-
RECQ_ECOLI
A:
[17-344]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
E
T
F
G
Y
Q
Q
F
R
P
G
Q
E
E
I
I
D
T
V
L
S
G
------
R
D
C
L
V
V
M
P
T
G
G
G
K
S
L
C
Y
Q
I
P
A
L
L
L
----------
N
G
L
T
V
V
V
S
P
L
I
S
L
M
K
D
Q
V
D
Q
L
Q
A
N
-----
G
V
---
A
---
A
A
C
L
N
S
T
Q
T
R
E
Q
Q
L
E
V
M
T
G
C
--
R
T
G
Q
I
R
L
L
Y
I
A
P
E
R
L
M
L
D
N
F
L
E
H
-----
L
A
H
W
N
P
V
L
L
A
V
D
E
A
H
----------
C
I
S
Q
---
W
GHD
F
-----
R
P
E
Y
-
A
---
A
L
---
G
Q
L
R
Q
R
-------
F
P
T
L
P
F
M
A
L
T
A
T
A
D
D
T
T
R
Q
D
I
V
R
L
L
G
L
N
D
P
--
L
I
Q
-
I
S
----
S
----
F
---
D
R
P
N
I
R
Y
M
L
--
M
--
E
K
F
--
K
P
L
D
---
Q
----
L
M
R
Y
V
Q
E
-----
Q
R
G
K
S
G
I
I
Y
C
N
S
-
R
A
K
V
E
D
T
A
A
R
L
-----
Q
S
-
K
----
G
I
S
A
A
A
Y
H
A
G
L
E
N
N
V
R
A
D
V
Q
E
K
F
Q
R
-
D
D
L
Q
I
V
V
A
T
V
A
F
G
M
G
I
N
K
P
N
V
R
F
V
V
H
F
D
I
P
-
R
N
I
E
S
Y
Y
Q
E
T
G
R
A
G
R
D
G
L
P
A
E
A
M
L
F
Y
D
P
A
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
HHSearch
39.39
16%
-2
- C1 -
-
5SUQ
3
SUB2_YEAST
A:
[72-413]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
S
R
A
I
I
D
C
G
F
E
-
H
P
S
E
V
Q
Q
H
T
I
P
Q
S
I
H
G
------
T
D
V
L
C
Q
A
K
S
G
L
G
K
T
A
V
F
V
L
S
T
L
Q
Q
L
D
P
VPG----
E
V
A
V
V
V
I
C
N
A
R
E
L
A
Y
Q
I
R
N
E
Y
L
R
F
S
K
Y
M
P
D
V
---
K
---
T
A
V
F
Y
G
G
T
P
I
S
K
D
A
E
L
L
K
N
---
K
D
T
A
P
H
I
V
V
A
T
P
G
R
L
K
A
L
V
R
E
KY-----
I
D
L
S
H
V
K
N
F
V
I
D
E
C
D
----------
K
V
L
E
---
E
L
D
-
M
R
R
D
V
-
Q
----
E
---
I
F
---
R
---
A
T
-------
P
R
D
K
Q
V
M
M
F
S
A
T
L
S
Q
E
I
R
P
I
C
R
R
--
F
L
Q
N
P
--
L
E
I
F
V
-----------------
G
L
Q
Q
Y
Y
--
I
--
K
L
E
--
E
--
R
---
E
----
K
N
R
K
L
A
Q
L
L
D
D
-
L
E
F
N
Q
V
I
I
F
V
K
S
-
T
T
R
A
N
E
L
T
K
L
L
-----
N
A
-
S
----
N
F
P
A
I
T
V
H
G
H
M
K
Q
E
E
R
I
A
R
Y
K
A
F
K
D
-
F
E
K
R
I
C
V
S
T
D
V
F
G
R
G
I
D
I
E
R
I
N
L
A
I
N
Y
D
L
T
-
N
E
A
D
Q
Y
L
H
R
V
G
R
A
G
R
F
G
T
K
G
L
A
I
S
F
V
S
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
HHSearch
38.76
19%
-16
- C1 -
-
4O3M
10
A:
[13-388]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
K
E
M
M
K
I
F
H
K
K
F
G
L
H
N
F
R
T
N
Q
L
E
A
I
N
A
A
L
L
G
------
E
D
C
F
I
L
M
P
T
G
G
G
K
S
L
C
Y
Q
L
P
A
C
V
S
----------
P
G
V
T
V
V
I
S
P
L
R
S
L
I
V
D
Q
V
Q
K
L
T
S
L
-----
D
I
---
P
---
A
T
Y
L
T
G
D
K
T
D
S
E
A
T
N
I
Y
L
Q
L
S
K
K
D
P
I
I
K
L
L
Y
V
T
P
E
K
I
C
A
S
N
R
L
I
S
T
L
E
N
L
Y
E
R
K
L
L
A
R
F
V
I
D
E
A
H
---------------------------
R
Q
D
Y
-
K
---
R
M
N
M
L
R
---
Q
K
-------
F
P
S
V
P
V
M
A
L
T
A
T
A
N
P
R
V
Q
K
D
I
L
T
Q
L
K
I
L
R
P
--
Q
V
F
S
M
-----
S
----
F
---
N
R
H
N
L
K
Y
Y
V
--
L
--
P
K
K
--
P
--
K
---
K
V
A
F
D
C
L
E
W
I
R
K
-
H
---
H
P
Y
D
S
G
I
I
Y
C
L
S
-
R
R
E
C
D
T
M
A
D
T
L
-----
Q
R
-
D
----
G
L
A
A
L
A
Y
H
A
G
L
S
D
S
A
R
D
E
V
Q
Q
K
W
I
N
Q
D
G
C
Q
V
I
C
A
T
I
A
F
G
M
G
I
D
K
P
D
V
R
F
V
I
H
A
S
L
P
K
-
S
V
E
G
Y
Y
Q
E
S
G
R
A
G
R
D
G
E
I
S
H
C
L
L
F
Y
T
Y
H
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
HHSearch
38.36
16%
9
- C1 -
-
5SUP
2
SUB2_YEAST
A:
[16-357]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
S
R
A
I
I
D
C
G
F
E
-
H
P
S
E
V
Q
Q
H
T
I
P
Q
S
I
H
G
------
T
D
V
L
C
Q
A
K
S
G
L
G
K
T
A
V
F
V
L
S
T
L
Q
Q
L
D
P
VPG----
E
V
A
V
V
V
I
C
N
A
R
E
L
A
Y
Q
I
R
N
E
Y
L
R
F
S
K
Y
M
P
D
V
---
K
---
T
A
V
F
Y
G
G
T
P
I
S
K
D
A
E
L
L
K
N
---
K
D
T
A
P
H
I
V
V
A
T
P
G
R
L
K
A
L
V
R
E
KY-----
I
D
L
S
H
V
K
N
F
V
I
D
E
C
D
----------
K
V
L
E
---
E
L
D
-
M
R
R
D
V
-
Q
----
E
---
I
F
---
R
---
A
T
-------
P
R
D
K
Q
V
M
M
F
S
A
T
L
S
Q
E
I
R
P
I
C
R
R
--
F
L
Q
N
P
--
L
E
I
F
V
D
----
D
----
E
AKL
T
L
H
G
L
Q
Q
Y
Y
--
I
--
K
L
E
--
E
--
R
---
E
----
K
N
R
K
L
A
Q
L
L
D
D
-
L
E
F
N
Q
V
I
I
F
V
K
S
-
T
T
R
A
N
E
L
T
K
L
L
-----
N
A
-
S
----
N
F
P
A
I
T
V
H
G
H
M
K
Q
E
E
R
I
A
R
Y
K
A
F
K
D
-
F
E
K
R
I
C
V
S
T
D
V
F
G
R
G
I
D
I
E
R
I
N
L
A
I
N
Y
D
L
T
-
N
E
A
D
Q
Y
L
H
R
V
G
R
A
G
R
F
G
T
K
G
L
A
I
S
F
V
S
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
HHSearch
38.08
19%
19
- C1 -
-
4TYN
2
MS116_YEAST
A:
[40-396]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-
G
L
T
P
V
Q
Q
K
T
I
K
P
I
L
S
S
----
E
D
H
D
V
I
A
R
A
K
T
G
T
G
K
T
F
A
F
L
I
P
I
F
Q
H
L
I
N
T
K
FDSQY
M
V
K
A
V
I
V
A
P
T
R
D
L
A
L
Q
I
E
A
E
V
K
K
I
H
D
M
N
Y
G
L
---
K
KY
A
C
V
S
L
V
G
G
T
D
F
R
---
A
A
M
N
K
M
--
N
K
L
R
P
N
I
V
I
A
T
P
G
R
L
I
D
V
L
E
K
YSN----
K
F
F
R
F
V
D
Y
K
V
L
D
E
A
D
----------
R
L
L
E
---
I
---
G
F----
R
D
D
L
E
T
---
I
S
---
G
---
I
L
N
E
K
NSKS
A
D
N
I
K
T
L
L
F
S
A
T
L
D
D
K
V
Q
K
L
A
N
N
--
I
M
N
K
K
E
C
L
F
L
D
T
V
DKNE
P
----
E
---
A
H
E
R
I
D
Q
S
V
--
V
I
S
E
K
F
--
A
--
N
S
I
F
A
----
A
V
E
H
I
K
K
Q
I
K
E
R
D
S
N
Y
K
A
I
I
F
A
P
T
-
V
K
F
T
S
F
L
C
S
I
L
-----
K
N
-
E
F
K
K
-
D
L
P
I
L
E
F
H
G
K
I
T
Q
N
K
R
T
S
L
V
K
R
F
K
K
-
D
E
S
G
I
L
V
C
T
D
V
G
A
R
G
M
D
F
P
N
V
H
E
V
L
Q
I
G
V
P
-
S
E
L
A
N
Y
I
H
R
I
G
R
T
A
R
S
G
K
E
G
S
S
V
L
F
I
C
K
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
HHSearch
37.93
18%
-9
- C1 -
-
4U7D
-
RECQ1_HUMAN
C:
[31-375]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
K
D
I
L
Q
N
V
F
K
L
E
K
F
R
P
L
Q
L
E
T
I
N
V
T
M
A
G
------
K
E
V
F
L
V
M
P
T
G
G
G
K
S
L
C
Y
Q
L
P
A
L
C
S
----------
D
G
F
T
L
V
I
C
P
L
I
S
L
M
E
D
Q
L
M
V
L
K
Q
L
-----
G
I
---
S
---
A
T
M
L
N
A
S
S
S
K
E
H
V
K
W
V
H
A
E
M
VN
K
N
S
E
L
K
L
I
Y
V
T
P
E
K
I
A
K
S
KMFMSRLEKA
Y
E
A
R
R
F
T
R
I
A
V
D
E
V
H
----------
C
C
S
Q
WGH
D
---
F
-----
R
PDY-
K
ALG
I
L
---
K
---
R
Q
-------
F
P
N
A
S
L
I
G
L
T
A
T
A
T
N
H
V
L
T
D
A
Q
K
IL
C
I
E
K
C
--
F
T
F
-
T
A
----
S
----
F
---
N
R
P
N
L
Y
Y
E
V
--
R
--
Q
K
P
SN
T
--
E
---
D
----
F
I
E
D
I
V
K
L
I
NGR
Y
K
G
Q
S
G
I
I
Y
C
F
S
-
Q
K
D
S
E
Q
V
T
V
S
L
-----
Q
N
-
L
----
G
I
H
A
G
A
Y
H
A
N
L
E
P
E
D
K
T
T
V
H
R
K
W
S
A
-
N
E
I
Q
V
V
V
A
T
V
A
F
G
M
G
I
D
K
P
D
V
R
F
V
I
H
H
S
M
S
K
-
S
M
E
N
Y
Y
Q
E
S
G
R
A
G
R
D
D
M
K
A
D
C
I
L
Y
Y
G
F
G
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
HHSearch
37.57
18%
19
- C1 -
-
3SQW
2
MS116_YEAST
A:
[41-398]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
-
G
L
T
P
V
Q
Q
K
T
I
K
P
I
L
S
S
----
E
D
H
D
V
I
A
R
A
K
T
G
T
G
K
T
F
A
F
L
I
P
I
F
Q
H
L
I
N
T
KFDSQY
M
V
K
A
V
I
V
A
P
T
R
D
L
A
L
Q
I
E
A
E
V
K
K
I
H
D
M
N
Y
G
L
KKY
A
---
C
V
S
L
V
G
G
T
D
F
R
---
A
A
M
N
K
M
--
N
K
L
R
P
N
I
V
I
A
T
P
G
R
L
I
D
V
L
E
K
YSN----
K
F
F
R
F
V
D
Y
K
V
L
D
E
A
D
----------
R
L
L
E
---
I
---
G
F
R
D
D
L
E
----
T
---
I
S
---
G
---
I
L
N
E
K
NSKS
A
D
N
I
K
T
L
L
F
S
A
T
L
D
D
K
V
Q
K
L
A
N
N
--
I
M
N
K
K
EC
L
F
L
D
T
V
----
D
KNEP
E
---
A
H
E
R
I
D
Q
S
V
V
I
S
--
E
K
F
--
A
--
N
S
I
F
A
----
A
V
E
H
I
K
K
Q
I
K
E
R
D
S
N
Y
K
A
I
I
F
A
P
T
-
V
K
F
T
S
F
L
C
S
I
L
-----
K
N
-
E
F
-
K
K
D
L
P
I
L
E
F
H
G
K
I
T
Q
N
K
R
T
S
L
V
K
R
F
K
K
-
D
E
S
G
I
L
V
C
T
D
V
G
A
R
G
M
D
F
P
N
V
H
E
V
L
Q
I
G
V
P
-
S
E
L
A
N
Y
I
H
R
I
G
R
T
A
R
S
G
K
E
G
S
S
V
L
F
I
C
K
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------