@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr0012: (2017-12-13 )
MKKQNNGLIKNPFLWLLFIFFLVTGFQYFYSGNNSGGSQQINYTELVQEITDGNVKELTYQPNGSVIEVSGVYKNPKTSKEGTGIQFFTPSVTKVEKFTSTILPADTTVSELQKLATDHKAEVTVKHESSSGIWINLLVSIVPFGILFFFLFSMMGNMGGGNGRNPMSFGRSKAKAANKEDIKVRFSDVAGAEEEKQELVEVVEFLKDPKRFTKLGARIPAGVLLEGPPGTGKTLLAKAVAGEAGVPFFSISGSDFVEMFVGVGASRVRSLFEDAKKAAPAIIFIDEIDAVGRQRGVGLGGGNDEREQTLNQLLIEMDGFEGNEGIIVIAATNRSDVLDPALLRPGRFDRKVLVGRPDVKGREAILKVHAKNKPLAEDVDLKLVAQQTPGFVGADLENVLNEAALVAARRNKSIIDASDIDEAEDRVIAGPSKKDKTVSQKERELVAYHEAGHTIVGLVLSNARVVHKVTIVPRGRAGGYMIALPKEDQMLLSKEDMKEQLAGLMGGRVAEEIIFNVQTTGASNDFEQATQMARAMVTEYGMSEKLGPVQYEGNHAMLGAQSPQKSISEQTAYEIDEEVRSLLNEARNKAAEIIQSNRETHKLIAEALLKYETLDSTQIKALYETGKMPEAVEEESHALSYDEVKSKMNDEK
Atome Classification :
(39 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160--........170.......180.......190.......200...-....210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320-.......330.......340.......350.......360.......370.......380-........390.......400.......410.......420.......430.......440.......450.......460.......470...-.-...480.......490.......500.......510......--.520.......530.......540.......550-........560..-.....570.......580.......590.......600.......610.......620.......630.......640.......650
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MKKQNNGLIK
N
P
F
L
W
L
L
F
I
F
F
L
V
T
G
F
Q
Y
FYSGNNSGGSQQI
N
Y
T
E
L
V
Q
E
I
TDGNV
K
E
L
T
YQPNG
S
V
I
E
V
S
G
V
YKNPKTSKEGT
G
I
Q
F
FTP
S
V
T
K
V
E
K
F
T
S
TILPADT
T
V
S
E
L
Q
K
L
A
TDHK
A
E
V
T
V
K
HESSS
G
I
W
I
N
L
L
V
S
I
V
P
F
G
I
L
F
F
F
L
F
S
M
M
GNMGGG---NGRN
P
M
SFGRSKAKAANKE
D
I
K
V
R
F
SDVAG
A
E
E
E
K
Q
E
L
V
E
V
V
E
F
-
L
K
D
P
K
R
F
T
K
LGARIPA
G
V
L
L
EGPPGT
G
K
T
L
L
A
K
A
VAGEAGV
P
F
F
SIS
G
S
D
F
V
E
M
F
V
GV
G
A
S
R
V
R
S
L
F
E
D
A
K
KAA
P
A
I
I
F
I
DE
I
D
AVGRQRGVGLGGG
N
D
E
R
E
Q
T
L
N
Q
L
L
I
EMDGFEG-NE
G
I
I
V
I
A
ATNRSDVL
D
P
A
LLRPGRFDR
K
V
LVGRPDVK
G
R
E
A
I
L
K
V
HAKNKPLAEDV
D
L
--
K
L
V
A
QQTPGFV
G
A
D
L
E
N
V
L
N
E
A
A
L
V
A
ARRNKSIIDASDIDEAED
R
V
IAGPSKKDK
T
V
S
Q
K
E
R
E
L
V
A
Y
HEAG
H
T
I
V
G
L
V
LSN
A
R
V
V
H
K
V
T
I
V
PRG-R-AG
G
Y
M
I
A
LPKE
D
Q
M
LL
S
K
E
D
M
K
E
Q
L
A
G
LMG
G
R
V
A
E
E
I
I
F
N
V
Q--TTGASN
D
F
E
Q
A
T
Q
M
A
R
A
M
V
T
EYGMSEKLG
P
V
Q
Y--EGN
H
A
M
LGAQS
P
Q
-
K
S
I
S
E
Q
T
A
Y
E
I
D
E
E
V
R
S
L
L
N
E
A
R
N
K
A
A
E
I
I
Q
SN
R
E
T
H
K
L
I
A
E
A
L
L
K
YETL
D
S
T
Q
I
K
A
L
Y
ETGKM
P
E
A
V
E
E
E
SHAL
S
Y
D
E
V
K
S
K
MNDEK
125
HHSearch
85.57
58%
-91
- C2 -
-
2DHR
1
FTSH_THET8
E:
[24-471]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
K
V
T
F
K
D
V
A
G
A
E
E
A
K
E
E
L
K
E
I
V
E
F
-
L
K
N
P
S
R
F
H
E
M
G
A
R
I
P
K
G
V
L
L
V
G
P
P
G
V
G
K
T
H
L
A
R
A
V
A
G
E
A
R
V
P
F
I
T
A
S
G
S
D
F
V
E
M
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
R
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
R
K
R
G
S
G
V
G
G
G
N
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
E
K
-
D
T
A
I
V
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
I
A
I
D
A
P
D
V
K
G
R
E
Q
I
L
R
I
H
A
R
G
K
P
L
A
E
D
V
D
L
--
A
L
L
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
L
N
E
A
A
L
L
A
A
R
E
G
R
R
K
I
T
M
K
D
L
E
E
A
A
D
R
V
M
M
L
P
A
K
K
S
L
V
L
S
P
R
D
R
R
I
T
A
Y
H
E
A
G
H
A
L
A
A
H
F
L
E
H
A
D
G
V
H
K
V
T
I
V
P
R
G
-
R
-
A
L
G
F
M
M
P
R
R
E
-
D
M
L
H
W
S
R
K
R
L
L
D
Q
I
A
V
A
L
A
G
R
A
A
E
E
I
V
F
D
D
V
--
T
T
G
A
E
N
D
F
R
Q
A
T
E
L
A
R
R
M
I
T
E
W
G
M
H
P
E
F
G
P
V
A
Y
--
A
V
R
E
D
T
Y
L
G
G
Y
D
V
-
R
Q
Y
S
E
E
T
A
K
R
I
D
E
A
V
R
R
L
I
E
E
Q
Y
Q
R
V
K
A
L
L
L
E
K
R
E
V
L
E
R
V
A
E
T
L
L
E
R
E
T
L
T
A
E
E
F
Q
R
V
V
E
G
L
P
L
------------------------
112
Fugue
85.48
56%
-96
- C2 -
-
2CE7
-
FTSH_THEMA
A:
[5-457]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
K
P
S
G
N
K
R
V
T
F
K
D
V
G
G
A
E
E
A
I
E
E
L
K
E
V
V
E
F
-
L
K
D
P
S
K
F
N
R
I
G
A
R
M
P
K
G
I
L
L
V
G
P
P
G
T
G
K
T
L
L
A
R
A
V
A
G
E
A
N
V
P
F
F
H
I
S
G
S
D
F
V
E
L
F
V
G
V
G
A
A
R
V
R
D
L
F
A
Q
A
K
A
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
R
---------
H
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
D
S
-
K
E
G
I
I
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
K
K
I
V
V
D
P
P
D
M
L
G
R
K
K
I
L
E
I
H
T
R
N
K
P
L
A
E
D
V
N
L
--
E
I
I
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
V
N
E
A
A
L
L
A
A
R
E
G
R
D
K
I
T
M
K
D
F
E
E
A
I
D
R
V
I
--------
L
I
S
P
A
E
K
R
I
I
A
Y
H
E
A
G
H
A
V
V
S
T
V
V
P
N
G
E
P
V
H
R
I
S
I
I
K
Y
L
-
V
-----------------
S
R
N
E
L
L
D
K
L
T
A
L
L
G
G
R
A
A
E
E
V
V
F
G
D
V
--
T
S
G
A
A
N
D
I
E
R
A
T
E
I
A
R
N
M
V
C
Q
L
G
M
S
E
E
L
G
P
L
A
W
--
G
K
----------
L
-
R
N
Y
S
E
E
V
A
S
K
I
D
E
E
V
K
K
I
V
T
N
C
Y
E
R
A
K
E
I
I
R
K
Y
R
K
Q
L
D
N
I
V
E
I
L
L
E
K
E
T
I
E
G
D
E
L
R
R
I
L
S
----------------------------
33
PsiBlast_CBE
84.68
57%
-90
- C2 -
-
2DHR
1
FTSH_THET8
E:
[18-467]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
R
V
L
T
-
E
A
P
K
V
T
F
K
D
V
A
G
A
E
E
A
K
E
E
L
K
E
I
V
E
F
-
L
K
N
P
S
R
F
H
E
M
G
A
R
I
P
K
G
V
L
L
V
G
P
P
G
V
G
K
T
H
L
A
R
A
V
A
G
E
A
R
V
P
F
I
T
A
S
G
S
D
F
V
E
M
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
R
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
R
K
R
G
S
G
V
G
G
G
N
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
E
K
-
D
T
A
I
V
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
I
A
I
D
A
P
D
V
K
G
R
E
Q
I
L
R
I
H
A
R
G
K
P
L
A
E
D
V
D
L
--
A
L
L
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
L
N
E
A
A
L
L
A
A
R
E
G
R
R
K
I
T
M
K
D
L
E
E
A
A
D
R
V
M
M
L
P
A
K
K
S
L
V
L
S
P
R
D
R
R
I
T
A
Y
H
E
A
G
H
A
L
A
A
H
F
L
E
H
A
D
G
V
H
K
V
T
I
V
P
R
G
-
R
-
A
L
G
F
M
M
P
R
-
R
E
D
M
L
H
W
S
R
K
R
L
L
D
Q
I
A
V
A
L
A
G
R
A
A
E
E
I
V
F
D
D
V
--
T
T
G
A
E
N
D
F
R
Q
A
T
E
L
A
R
R
M
I
T
E
W
G
M
H
P
E
F
G
P
V
A
Y
--
A
V
R
E
D
T
Y
L
G
G
Y
D
V
-
R
Q
Y
S
E
E
T
A
K
R
I
D
E
A
V
R
R
L
I
E
E
Q
Y
Q
R
V
K
A
L
L
L
E
K
R
E
V
L
E
R
V
A
E
T
L
L
E
R
E
T
L
T
A
E
E
F
Q
R
V
V
E
----------------------------
3
PsiBlast_PDB
84.49
57%
-88
- C2 -
-
2DHR
1
FTSH_THET8
A:
[18-467]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
R
V
L
T
-
E
A
P
K
V
T
F
K
D
V
A
G
A
E
E
A
K
E
E
L
K
E
I
V
E
F
-
L
K
N
P
S
R
F
H
E
M
G
A
R
I
P
K
G
V
L
L
V
G
P
P
G
V
G
K
T
H
L
A
R
A
V
A
G
E
A
R
V
P
F
I
T
A
S
G
S
D
F
V
E
M
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
R
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
R
K
R
G
S
G
V
G
G
G
N
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
E
K
-
D
T
A
I
V
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
I
A
I
D
A
P
D
V
K
G
R
E
Q
I
L
R
I
H
A
R
G
K
P
L
A
E
D
V
D
L
--
A
L
L
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
L
N
E
A
A
L
L
A
A
R
E
G
R
R
K
I
T
M
K
D
L
E
E
A
A
D
R
V
M
M
L
P
A
K
K
S
L
V
L
S
P
R
D
R
R
I
T
A
Y
H
E
A
G
H
A
L
A
A
H
F
L
E
H
A
D
G
V
H
K
V
T
I
V
P
R
G
-
R
-
A
L
G
F
M
M
P
R
-
R
E
D
M
L
H
W
S
R
K
R
L
L
D
Q
I
A
V
A
L
A
G
R
A
A
E
E
I
V
F
D
D
V
--
T
T
G
A
E
N
D
F
R
Q
A
T
E
L
A
R
R
M
I
T
E
W
G
M
H
P
E
F
G
P
V
A
Y
--
A
V
R
E
D
T
Y
L
G
G
Y
D
V
-
R
Q
Y
S
E
E
T
A
K
R
I
D
E
A
V
R
R
L
I
E
E
Q
Y
Q
R
V
K
A
L
L
L
E
K
R
E
V
L
E
R
V
A
E
T
L
L
E
R
E
T
L
T
A
E
E
F
Q
R
V
V
E
----------------------------
123
HHSearch
84.45
56%
-56
- C2 -
-
3KDS
1
FTSH_THEMA
E:
[11-458]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
V
T
F
K
D
V
G
G
A
E
E
A
I
E
E
L
K
E
V
V
E
F
-
L
K
D
P
S
K
F
N
R
I
G
A
R
M
P
K
G
I
L
L
V
G
P
P
G
T
G
A
T
L
L
A
R
A
V
A
G
E
A
N
V
P
F
F
H
I
S
G
S
D
F
V
E
L
F
V
G
V
G
A
A
R
V
R
D
L
F
A
Q
A
K
A
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
R
H
---------
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
D
S
-
K
E
G
I
I
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
K
K
I
V
V
D
P
P
D
M
L
G
R
K
K
I
L
E
I
H
T
R
N
K
P
L
A
E
D
V
N
L
--
E
I
I
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
V
N
E
A
A
L
L
A
A
R
E
G
R
D
K
I
T
M
K
D
F
E
E
A
I
D
R
V
I
A
G
P
A
R
K
S
L
L
I
S
P
A
E
K
R
I
I
A
Y
H
E
A
G
H
A
V
V
S
T
V
V
P
N
G
E
P
V
H
R
I
S
I
I
P
R
G
-
Y
K
A
L
G
Y
T
L
H
L
P
E
E
D
K
Y
L
V
S
R
N
E
L
L
D
K
L
T
A
L
L
G
G
R
A
A
E
E
V
V
F
G
D
V
--
T
S
G
A
A
N
D
I
E
R
A
T
E
I
A
R
N
M
V
C
Q
L
G
M
S
E
E
L
G
P
L
A
W
--
G
K
---------
R
L
-
R
N
Y
S
E
E
V
A
S
K
I
D
E
E
V
K
K
I
V
T
N
C
Y
E
R
A
K
E
I
I
R
K
Y
R
K
Q
L
D
N
I
V
E
I
L
L
E
K
E
T
I
E
G
D
E
L
R
R
I
L
S
E
---------------------------
35
PsiBlast_CBE
84.43
57%
-89
- C2 -
-
2DHR
1
FTSH_THET8
C:
[18-467]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
R
V
L
T
-
E
A
P
K
V
T
F
K
D
V
A
G
A
E
E
A
K
E
E
L
K
E
I
V
E
F
-
L
K
N
P
S
R
F
H
E
M
G
A
R
I
P
K
G
V
L
L
V
G
P
P
G
V
G
K
T
H
L
A
R
A
V
A
G
E
A
R
V
P
F
I
T
A
S
G
S
D
F
V
E
M
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
R
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
R
K
R
G
S
G
V
G
G
G
N
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
E
K
-
D
T
A
I
V
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
I
A
I
D
A
P
D
V
K
G
R
E
Q
I
L
R
I
H
A
R
G
K
P
L
A
E
D
V
D
L
--
A
L
L
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
L
N
E
A
A
L
L
A
A
R
E
G
R
R
K
I
T
M
K
D
L
E
E
A
A
D
R
V
M
M
L
P
A
K
K
S
L
V
L
S
P
R
D
R
R
I
T
A
Y
H
E
A
G
H
A
L
A
A
H
F
L
E
H
A
D
G
V
H
K
V
T
I
V
P
R
G
-
R
-
A
L
G
F
M
M
P
R
-
R
E
D
M
L
H
W
S
R
K
R
L
L
D
Q
I
A
V
A
L
A
G
R
A
A
E
E
I
V
F
D
D
V
--
T
T
G
A
E
N
D
F
R
Q
A
T
E
L
A
R
R
M
I
T
E
W
G
M
H
P
E
F
G
P
V
A
Y
--
A
V
R
E
D
T
Y
L
G
G
Y
D
V
-
R
Q
Y
S
E
E
T
A
K
R
I
D
E
A
V
R
R
L
I
E
E
Q
Y
Q
R
V
K
A
L
L
L
E
K
R
E
V
L
E
R
V
A
E
T
L
L
E
R
E
T
L
T
A
E
E
F
Q
R
V
V
E
----------------------------
1
PsiBlast_PDB
84.22
57%
-63
- C2 -
-
3KDS
1
FTSH_THEMA
E:
[12-455]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
F
K
D
V
G
G
A
E
E
A
I
E
E
L
K
E
V
V
E
F
-
L
K
D
P
S
K
F
N
R
I
G
A
R
M
P
K
G
I
L
L
V
G
P
P
G
T
G
A
T
L
L
A
R
A
V
A
G
E
A
N
V
P
F
F
H
I
S
G
S
D
F
V
E
L
F
V
G
V
G
A
A
R
V
R
D
L
F
A
Q
A
K
A
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
R
H
---------
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
D
S
-
K
E
G
I
I
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
K
K
I
V
V
D
P
P
D
M
L
G
R
K
K
I
L
E
I
H
T
R
N
K
P
L
A
E
D
V
N
L
--
E
I
I
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
V
N
E
A
A
L
L
A
A
R
E
G
R
D
K
I
T
M
K
D
F
E
E
A
I
D
R
V
I
A
G
P
A
R
K
S
L
L
I
S
P
A
E
K
R
I
I
A
Y
H
E
A
G
H
A
V
V
S
T
V
V
P
N
G
E
P
V
H
R
I
S
I
I
P
R
G
Y
K
-
A
L
G
Y
T
L
H
L
P
E
E
D
K
Y
L
V
S
R
N
E
L
L
D
K
L
T
A
L
L
G
G
R
A
A
E
E
V
V
F
G
D
V
--
T
S
G
A
A
N
D
I
E
R
A
T
E
I
A
R
N
M
V
C
Q
L
G
M
S
E
E
L
G
P
L
A
W
GK------------
R
L
R
N
Y
S
E
E
V
A
S
K
I
D
E
E
V
K
K
I
V
T
N
C
Y
E
R
A
K
E
I
I
R
K
Y
R
K
Q
L
D
N
I
V
E
I
L
L
E
K
E
T
I
E
G
D
E
L
R
R
I
------------------------------
30
PsiBlast_CBE
84.06
57%
-82
- C2 -
-
4EIW
1
FTSH_THET8
C:
[27-476]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
R
V
L
T
-
E
A
P
K
V
T
F
K
D
V
A
G
A
E
E
A
K
E
E
L
K
E
I
V
E
F
-
L
K
N
P
S
R
F
H
E
M
G
A
R
I
P
K
G
V
L
L
V
G
P
P
G
V
G
K
T
H
L
A
R
A
V
A
G
E
A
R
V
P
F
I
T
A
S
G
S
D
F
V
E
M
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
R
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
R
K
R
G
S
G
V
G
G
G
N
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
E
K
-
D
T
A
I
V
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
I
A
I
D
A
P
D
V
K
G
R
E
Q
I
L
R
I
H
A
R
G
K
P
L
A
E
D
V
D
L
--
A
L
L
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
L
N
E
A
A
L
L
A
A
R
E
G
R
R
K
I
T
M
K
D
L
E
E
A
A
D
R
V
M
M
L
P
A
K
K
S
L
V
L
S
P
R
D
R
R
I
T
A
Y
H
E
A
G
H
A
L
A
A
H
F
L
E
H
A
D
G
V
H
K
V
T
I
V
P
R
G
-
R
-
A
L
G
F
M
M
P
R
-
R
E
D
M
L
H
W
S
R
K
R
L
L
D
Q
I
A
V
A
L
A
G
R
A
A
E
E
I
V
F
D
D
V
--
T
T
G
A
E
N
D
F
R
Q
A
T
E
L
A
R
R
M
I
T
E
W
G
M
H
P
E
F
G
P
V
A
Y
--
A
V
R
E
D
T
Y
L
G
G
Y
D
V
-
R
Q
Y
S
E
E
T
A
K
R
I
D
E
A
V
R
R
L
I
E
E
Q
Y
Q
R
V
K
A
L
L
L
E
K
R
E
V
L
E
R
V
A
E
T
L
L
E
R
E
T
L
T
A
E
E
F
Q
R
V
V
E
----------------------------
28
PsiBlast_CBE
83.76
57%
-83
- C2 -
-
4EIW
1
FTSH_THET8
E:
[27-476]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
R
V
L
T
-
E
A
P
K
V
T
F
K
D
V
A
G
A
E
E
A
K
E
E
L
K
E
I
V
E
F
-
L
K
N
P
S
R
F
H
E
M
G
A
R
I
P
K
G
V
L
L
V
G
P
P
G
V
G
K
T
H
L
A
R
A
V
A
G
E
A
R
V
P
F
I
T
A
S
G
S
D
F
V
E
M
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
R
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
R
K
R
G
S
G
V
G
G
G
N
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
E
K
-
D
T
A
I
V
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
I
A
I
D
A
P
D
V
K
G
R
E
Q
I
L
R
I
H
A
R
G
K
P
L
A
E
D
V
D
L
--
A
L
L
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
L
N
E
A
A
L
L
A
A
R
E
G
R
R
K
I
T
M
K
D
L
E
E
A
A
D
R
V
M
M
L
P
A
K
K
S
L
V
L
S
P
R
D
R
R
I
T
A
Y
H
E
A
G
H
A
L
A
A
H
F
L
E
H
A
D
G
V
H
K
V
T
I
V
P
R
G
-
R
-
A
L
G
F
M
M
P
R
-
R
E
D
M
L
H
W
S
R
K
R
L
L
D
Q
I
A
V
A
L
A
G
R
A
A
E
E
I
V
F
D
D
V
--
T
T
G
A
E
N
D
F
R
Q
A
T
E
L
A
R
R
M
I
T
E
W
G
M
H
P
E
F
G
P
V
A
Y
--
A
V
R
E
D
T
Y
L
G
G
Y
D
V
-
R
Q
Y
S
E
E
T
A
K
R
I
D
E
A
V
R
R
L
I
E
E
Q
Y
Q
R
V
K
A
L
L
L
E
K
R
E
V
L
E
R
V
A
E
T
L
L
E
R
E
T
L
T
A
E
E
F
Q
R
V
V
E
----------------------------
2
PsiBlast_PDB
83.73
57%
-83
- C2 -
-
4EIW
1
FTSH_THET8
A:
[27-476]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
R
V
L
T
-
E
A
P
K
V
T
F
K
D
V
A
G
A
E
E
A
K
E
E
L
K
E
I
V
E
F
-
L
K
N
P
S
R
F
H
E
M
G
A
R
I
P
K
G
V
L
L
V
G
P
P
G
V
G
K
T
H
L
A
R
A
V
A
G
E
A
R
V
P
F
I
T
A
S
G
S
D
F
V
E
M
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
R
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
R
K
R
G
S
G
V
G
G
G
N
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
E
K
-
D
T
A
I
V
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
I
A
I
D
A
P
D
V
K
G
R
E
Q
I
L
R
I
H
A
R
G
K
P
L
A
E
D
V
D
L
--
A
L
L
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
L
N
E
A
A
L
L
A
A
R
E
G
R
R
K
I
T
M
K
D
L
E
E
A
A
D
R
V
M
M
L
P
A
K
K
S
L
V
L
S
P
R
D
R
R
I
T
A
Y
H
E
A
G
H
A
L
A
A
H
F
L
E
H
A
D
G
V
H
K
V
T
I
V
P
R
G
-
R
-
A
L
G
F
M
M
P
R
-
R
E
D
M
L
H
W
S
R
K
R
L
L
D
Q
I
A
V
A
L
A
G
R
A
A
E
E
I
V
F
D
D
V
--
T
T
G
A
E
N
D
F
R
Q
A
T
E
L
A
R
R
M
I
T
E
W
G
M
H
P
E
F
G
P
V
A
Y
--
A
V
R
E
D
T
Y
L
G
G
Y
D
V
-
R
Q
Y
S
E
E
T
A
K
R
I
D
E
A
V
R
R
L
I
E
E
Q
Y
Q
R
V
K
A
L
L
L
E
K
R
E
V
L
E
R
V
A
E
T
L
L
E
R
E
T
L
T
A
E
E
F
Q
R
V
V
E
----------------------------
32
PsiBlast_CBE
80.01
57%
-80
- C2 -
-
2DHR
1
FTSH_THET8
F:
[18-467]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
R
V
L
T
-
E
A
P
K
V
T
F
K
D
V
A
G
A
E
E
A
K
E
E
L
K
E
I
V
E
F
-
L
K
N
P
S
R
F
H
E
M
G
A
R
I
P
K
G
V
L
L
V
G
P
P
G
V
G
K
T
H
L
A
R
A
V
A
G
E
A
R
V
P
F
I
T
A
S
G
S
D
F
V
E
M
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
R
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
R
K
--------
N
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
E
K
-
D
T
A
I
V
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
I
A
I
D
A
P
D
V
K
G
R
E
Q
I
L
R
I
H
A
R
G
K
P
L
A
E
D
V
D
L
--
A
L
L
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
L
N
E
A
A
L
L
A
A
R
E
G
R
R
K
I
T
M
K
D
L
E
E
A
A
D
R
V
M
M
L
P
A
K
K
S
L
V
L
S
P
R
D
R
R
I
T
A
Y
H
E
A
G
H
A
L
A
A
H
F
L
E
H
A
D
G
V
H
K
V
T
I
V
P
R
G
-
R
-
A
L
G
F
M
M
P
R
-
R
E
D
M
L
H
W
S
R
K
R
L
L
D
Q
I
A
V
A
L
A
G
R
A
A
E
E
I
V
F
D
D
V
--
T
T
G
A
E
N
D
F
R
Q
A
T
E
L
A
R
R
M
I
T
E
W
G
M
H
P
E
F
G
P
V
A
Y
--
A
V
R
E
D
T
Y
L
G
G
Y
D
V
-
R
Q
Y
S
E
E
T
A
K
R
I
D
E
A
V
R
R
L
I
E
E
Q
Y
Q
R
V
K
A
L
L
L
E
K
R
E
V
L
E
R
V
A
E
T
L
L
E
R
E
T
L
T
A
E
E
F
Q
R
V
V
E
----------------------------
4
PsiBlast_PDB
79.92
55%
-50
- C2 -
-
4WW0
1
FTSH_AQUAE
A:
[4-459]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
K
V
Y
I
E
E
K
P
K
V
T
F
K
D
V
A
G
I
E
E
V
K
E
E
V
K
E
I
I
E
Y
-
L
K
D
P
V
K
F
Q
K
L
G
G
R
P
P
K
G
V
L
L
Y
G
E
P
G
V
G
K
T
L
L
A
K
A
I
A
G
E
A
H
V
P
F
I
S
V
S
G
S
D
F
V
E
M
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
K
H
A
P
C
M
I
F
I
D
E
I
D
A
V
G
R
-----------
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
D
T
-
S
D
G
I
I
V
I
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
I
F
I
P
K
P
D
V
R
G
R
Y
E
I
L
K
V
H
A
R
N
K
K
L
A
K
D
V
D
L
--
E
F
V
A
R
A
T
P
G
L
T
G
A
D
L
E
N
L
L
N
E
A
A
L
L
A
A
R
K
G
K
E
E
I
T
M
E
E
I
E
E
A
L
D
R
I
T
M
-------
T
I
S
P
K
E
K
E
K
I
A
I
H
E
A
G
H
A
L
M
G
L
V
S
D
D
D
D
K
V
H
K
I
S
I
I
P
------------------
H
I
Y
D
K
K
D
L
Y
N
K
I
L
V
L
L
G
G
R
A
A
E
E
V
F
F
G
K
D
GI
T
T
G
A
E
N
D
L
Q
R
A
T
D
L
A
Y
R
M
V
S
M
W
G
M
S
D
K
V
G
P
I
A
I
--
R
R
-------------
D
T
S
P
D
L
L
R
E
I
D
E
E
V
R
R
I
I
T
E
Q
Y
E
K
A
K
A
I
V
E
E
Y
K
E
P
L
K
A
V
V
K
K
L
L
E
K
E
T
I
T
C
E
E
F
V
E
V
F
K
----------------------------
124
HHSearch
79.83
56%
-54
- C2 -
-
2CE7
-
FTSH_THEMA
C:
[8-461]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
N
K
R
V
T
F
K
D
V
G
G
A
E
E
A
I
E
E
L
K
E
V
V
E
F
-
L
K
D
P
S
K
F
N
R
I
G
A
R
M
P
K
G
I
L
L
V
G
P
P
G
T
G
K
T
L
L
A
R
A
V
A
G
E
A
N
V
P
F
F
H
I
S
G
S
D
F
V
E
L
F
V
G
V
G
A
A
R
V
R
D
L
F
A
Q
A
K
A
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
-------------
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
D
S
-
K
E
G
I
I
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
K
K
I
V
V
D
P
P
D
M
L
G
R
K
K
I
L
E
I
H
T
R
N
K
P
L
A
E
D
V
N
L
--
E
I
I
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
V
N
E
A
A
L
L
A
A
R
E
G
R
D
K
I
T
M
K
D
F
E
E
A
I
D
R
V
I
--------
L
I
S
P
A
E
K
R
I
I
A
Y
H
E
A
G
H
A
V
V
S
T
V
V
P
N
G
E
P
V
H
R
I
S
I
I
P
R
G
-
Y
K
A
L
G
Y
T
L
H
L
P
E
E
D
K
Y
L
V
S
R
N
E
L
L
D
K
L
T
A
L
L
G
G
R
A
A
E
E
V
V
F
G
D
V
--
T
S
G
A
A
N
D
I
E
R
A
T
E
I
A
R
N
M
V
C
Q
L
G
M
S
E
E
L
G
P
L
A
W
--
G
-------------
R
N
Y
S
E
E
V
A
S
K
I
D
E
E
V
K
K
I
V
T
N
C
Y
E
R
A
K
E
I
I
R
K
Y
R
K
Q
L
D
N
I
V
E
I
L
L
E
K
E
T
I
E
G
D
E
L
R
R
I
L
S
E
E
F
E
------------------------
37
PsiBlast_CBE
79.66
55%
-43
- C2 -
-
4Z8X
1
FTSH_AQUAE
C:
[5-459]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
V
Y
I
E
E
K
P
K
V
T
F
K
D
V
A
G
I
E
E
V
K
E
E
V
K
E
I
I
E
Y
-
L
K
D
P
V
K
F
Q
K
L
G
G
R
P
P
K
G
V
L
L
Y
G
E
P
G
V
G
K
T
L
L
A
K
A
I
A
G
E
A
H
V
P
F
I
S
V
S
G
S
D
F
V
E
M
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
K
H
A
P
C
M
I
F
I
D
E
I
D
A
V
G
R
----------
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
D
T
-
S
D
G
I
I
V
I
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
I
F
I
P
K
P
D
V
R
G
R
Y
E
I
L
K
V
H
A
R
N
K
K
L
A
K
D
V
D
L
--
E
F
V
A
R
A
T
P
G
L
T
G
A
D
L
E
N
L
L
N
E
A
A
L
L
A
A
R
K
G
K
E
E
I
T
M
E
E
I
E
E
A
L
D
R
I
T
M
-------
T
I
S
P
K
E
K
E
K
I
A
I
H
E
A
G
H
A
L
M
G
L
V
S
D
D
D
D
K
V
H
K
I
S
I
I
P
-------------
P
I
E
D
K
H
I
Y
D
K
K
D
L
Y
N
K
I
L
V
L
L
G
G
R
A
A
E
E
V
F
F
G
K
D
GI
T
T
G
A
E
N
D
L
Q
R
A
T
D
L
A
Y
R
M
V
S
M
W
G
M
S
D
K
V
G
P
I
A
I
--
R
R
-------------
D
T
S
P
D
L
L
R
E
I
D
E
E
V
R
R
I
I
T
E
Q
Y
E
K
A
K
A
I
V
E
E
Y
K
E
P
L
K
A
V
V
K
K
L
L
E
K
E
T
I
T
C
E
E
F
V
E
V
F
K
----------------------------
39
PsiBlast_CBE
79.53
55%
-48
- C2 -
-
4WW0
2
FTSH_AQUAE
C:
[9-459]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
E
K
P
K
V
T
F
K
D
V
A
G
I
E
E
V
K
E
E
V
K
E
I
I
E
Y
-
L
K
D
P
V
K
F
Q
K
L
G
G
R
P
P
K
G
V
L
L
Y
G
E
P
G
V
G
K
T
L
L
A
K
A
I
A
G
E
A
H
V
P
F
I
S
V
S
G
S
D
----
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
K
H
A
P
C
M
I
F
I
D
E
I
D
A
V
G
R
----------
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
D
T
-
S
D
G
I
I
V
I
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
I
F
I
P
K
P
D
V
R
G
R
Y
E
I
L
K
V
H
A
R
N
K
K
L
A
K
D
V
D
L
--
E
F
V
A
R
A
T
P
G
L
T
G
A
D
L
E
N
L
L
N
E
A
A
L
L
A
A
R
K
G
K
E
E
I
T
M
E
E
I
E
E
A
L
D
R
---------
M
T
I
S
P
K
E
K
E
K
I
A
I
H
E
A
G
H
A
L
M
G
L
V
S
D
D
D
D
K
V
H
K
I
S
I
I
P
----------------
D
K
H
I
Y
D
K
K
D
L
Y
N
K
I
L
V
L
L
G
G
R
A
A
E
E
V
F
F
G
K
D
GI
T
T
G
A
E
N
D
L
Q
R
A
T
D
L
A
Y
R
M
V
S
M
W
G
M
S
D
K
V
G
P
I
A
I
--
R
-----------
A
-
V
D
T
S
P
D
L
L
R
E
I
D
E
E
V
R
R
I
I
T
E
Q
Y
E
K
A
K
A
I
V
E
E
Y
K
E
P
L
K
A
V
V
K
K
L
L
E
K
E
T
I
T
C
E
E
F
V
E
V
F
K
----------------------------
40
PsiBlast_CBE
79.33
55%
-41
- C2 -
-
4WW0
1
FTSH_AQUAE
B:
[3-459]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
A
K
V
Y
I
E
--
P
K
V
T
F
K
D
V
A
G
I
E
E
V
K
E
E
V
K
E
I
I
E
Y
-
L
K
D
P
V
K
F
Q
K
L
G
G
R
P
P
K
G
V
L
L
Y
G
E
P
G
V
G
K
T
L
L
A
K
A
I
A
G
E
A
H
V
P
F
I
S
V
S
G
S
D
F
V
E
M
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
K
H
A
P
C
M
I
F
I
D
E
I
D
A
V
G
R
----------
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
D
T
-
S
D
G
I
I
V
I
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
I
F
I
P
K
P
D
V
R
G
R
Y
E
I
L
K
V
H
A
R
N
K
K
L
A
K
D
V
D
L
--
E
F
V
A
R
A
T
P
G
L
T
G
A
D
L
E
N
L
L
N
E
A
A
L
L
A
A
R
K
G
K
E
E
I
T
M
E
E
I
E
E
A
L
D
R
I
--------
M
T
I
S
P
K
E
K
E
K
I
A
I
H
E
A
G
H
A
L
M
G
L
V
S
D
D
D
D
K
V
H
K
I
S
I
I
P
R
G
-
M
-
A
L
--------
E
D
K
H
I
Y
D
K
K
D
L
Y
N
K
I
L
V
L
L
G
G
R
A
A
E
E
V
F
F
G
K
D
GI
T
T
G
A
E
N
D
L
Q
R
A
T
D
L
A
Y
R
M
V
S
M
W
G
M
S
D
K
V
G
P
I
A
I
--
R
--------------
D
T
S
P
D
L
L
R
E
I
D
E
E
V
R
R
I
I
T
E
Q
Y
E
K
A
K
A
I
V
E
E
Y
K
E
P
L
K
A
V
V
K
K
L
L
E
K
E
T
I
T
C
E
E
F
V
E
V
F
K
----------------------------
34
PsiBlast_CBE
79.26
57%
-82
- C2 -
-
2DHR
1
FTSH_THET8
D:
[23-467]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
-
E
A
P
K
V
T
F
K
D
V
A
G
A
E
E
A
K
E
E
L
K
E
I
V
E
F
-
L
K
N
P
S
R
F
H
E
M
G
A
R
I
P
K
G
V
L
L
V
G
P
P
G
V
G
K
T
H
L
A
R
A
V
A
G
E
A
R
V
P
F
I
T
A
S
G
S
D
F
V
E
M
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
R
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
R
K
--------
N
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
E
K
-
D
T
A
I
V
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
I
A
I
D
A
P
D
V
K
G
R
E
Q
I
L
R
I
H
A
R
G
K
P
L
A
E
D
V
D
L
--
A
L
L
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
L
N
E
A
A
L
L
A
A
R
E
G
R
R
K
I
T
M
K
D
L
E
E
A
A
D
R
V
M
M
L
P
A
K
K
S
L
V
L
S
P
R
D
R
R
I
T
A
Y
H
E
A
G
H
A
L
A
A
H
F
L
E
H
A
D
G
V
H
K
V
T
I
V
P
R
G
-
R
-
A
L
G
F
M
M
P
R
-
R
E
D
M
L
H
W
S
R
K
R
L
L
D
Q
I
A
V
A
L
A
G
R
A
A
E
E
I
V
F
D
D
V
--
T
T
G
A
E
N
D
F
R
Q
A
T
E
L
A
R
R
M
I
T
E
W
G
M
H
P
E
F
G
P
V
A
Y
--
A
V
R
E
D
T
Y
L
G
G
Y
D
V
-
R
Q
Y
S
E
E
T
A
K
R
I
D
E
A
V
R
R
L
I
E
E
Q
Y
Q
R
V
K
A
L
L
L
E
K
R
E
V
L
E
R
V
A
E
T
L
L
E
R
E
T
L
T
A
E
E
F
Q
R
V
V
E
----------------------------
5
PsiBlast_PDB
79.22
55%
-41
- C2 -
-
4Z8X
1
FTSH_AQUAE
A:
[5-459]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
V
Y
I
E
E
K
P
K
V
T
F
K
D
V
A
G
I
E
E
V
K
E
E
V
K
E
I
I
E
Y
-
L
K
D
P
V
K
F
Q
K
L
G
G
R
P
P
K
G
V
L
L
Y
G
E
P
G
V
G
K
T
L
L
A
K
A
I
A
G
E
A
H
V
P
F
I
S
V
S
G
S
D
F
V
E
M
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
K
H
A
P
C
M
I
F
I
D
E
I
D
A
V
G
R
----------
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
D
T
-
S
D
G
I
I
V
I
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
I
F
I
P
K
P
D
V
R
G
R
Y
E
I
L
K
V
H
A
R
N
K
K
L
A
K
D
V
D
L
--
E
F
V
A
R
A
T
P
G
L
T
G
A
D
L
E
N
L
L
N
E
A
A
L
L
A
A
R
K
G
K
E
E
I
T
M
E
E
I
E
E
A
L
D
R
I
T
M
-------
T
I
S
P
K
E
K
E
K
I
A
I
H
E
A
G
H
A
L
M
G
L
V
S
D
D
D
D
K
V
H
K
I
S
I
I
P
-------------
P
I
E
D
K
H
I
Y
D
K
K
D
L
Y
N
K
I
L
V
L
L
G
G
R
A
A
E
E
V
F
F
G
K
D
GI
T
T
G
A
E
N
D
L
Q
R
A
T
D
L
A
Y
R
M
V
S
M
W
G
M
S
D
K
V
G
P
I
A
I
--
R
R
-------------
D
T
S
P
D
L
L
R
E
I
D
E
E
V
R
R
I
I
T
E
Q
Y
E
K
A
K
A
I
V
E
E
Y
K
E
P
L
K
A
V
V
K
K
L
L
E
K
E
T
I
T
C
E
E
F
V
E
V
F
K
----------------------------
36
PsiBlast_CBE
79.11
57%
-81
- C2 -
-
2DHR
1
FTSH_THET8
B:
[22-467]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
-
E
A
P
K
V
T
F
K
D
V
A
G
A
E
E
A
K
E
E
L
K
E
I
V
E
F
-
L
K
N
P
S
R
F
H
E
M
G
A
R
I
P
K
G
V
L
L
V
G
P
P
G
V
G
K
T
H
L
A
R
A
V
A
G
E
A
R
V
P
F
I
T
A
S
G
S
D
F
V
E
M
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
R
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
R
K
--------
N
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
E
K
-
D
T
A
I
V
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
I
A
I
D
A
P
D
V
K
G
R
E
Q
I
L
R
I
H
A
R
G
K
P
L
A
E
D
V
D
L
--
A
L
L
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
L
N
E
A
A
L
L
A
A
R
E
G
R
R
K
I
T
M
K
D
L
E
E
A
A
D
R
V
M
M
L
P
A
K
K
S
L
V
L
S
P
R
D
R
R
I
T
A
Y
H
E
A
G
H
A
L
A
A
H
F
L
E
H
A
D
G
V
H
K
V
T
I
V
P
R
G
-
R
-
A
L
G
F
M
M
P
R
-
R
E
D
M
L
H
W
S
R
K
R
L
L
D
Q
I
A
V
A
L
A
G
R
A
A
E
E
I
V
F
D
D
V
--
T
T
G
A
E
N
D
F
R
Q
A
T
E
L
A
R
R
M
I
T
E
W
G
M
H
P
E
F
G
P
V
A
Y
--
A
V
R
E
D
T
Y
L
G
G
Y
D
V
-
R
Q
Y
S
E
E
T
A
K
R
I
D
E
A
V
R
R
L
I
E
E
Q
Y
Q
R
V
K
A
L
L
L
E
K
R
E
V
L
E
R
V
A
E
T
L
L
E
R
E
T
L
T
A
E
E
F
Q
R
V
V
E
----------------------------
29
PsiBlast_CBE
78.89
57%
-81
- C2 -
-
4EIW
1
FTSH_THET8
D:
[31-476]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
-
E
A
P
K
V
T
F
K
D
V
A
G
A
E
E
A
K
E
E
L
K
E
I
V
E
F
-
L
K
N
P
S
R
F
H
E
M
G
A
R
I
P
K
G
V
L
L
V
G
P
P
G
V
G
K
T
H
L
A
R
A
V
A
G
E
A
R
V
P
F
I
T
A
S
G
S
D
F
V
E
M
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
R
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
R
K
--------
N
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
E
K
-
D
T
A
I
V
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
I
A
I
D
A
P
D
V
K
G
R
E
Q
I
L
R
I
H
A
R
G
K
P
L
A
E
D
V
D
L
--
A
L
L
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
L
N
E
A
A
L
L
A
A
R
E
G
R
R
K
I
T
M
K
D
L
E
E
A
A
D
R
V
M
M
L
P
A
K
K
S
L
V
L
S
P
R
D
R
R
I
T
A
Y
H
E
A
G
H
A
L
A
A
H
F
L
E
H
A
D
G
V
H
K
V
T
I
V
P
R
G
-
R
-
A
L
G
F
M
M
P
R
-
R
E
D
M
L
H
W
S
R
K
R
L
L
D
Q
I
A
V
A
L
A
G
R
A
A
E
E
I
V
F
D
D
V
--
T
T
G
A
E
N
D
F
R
Q
A
T
E
L
A
R
R
M
I
T
E
W
G
M
H
P
E
F
G
P
V
A
Y
--
A
V
R
E
D
T
Y
L
G
G
Y
D
V
-
R
Q
Y
S
E
E
T
A
K
R
I
D
E
A
V
R
R
L
I
E
E
Q
Y
Q
R
V
K
A
L
L
L
E
K
R
E
V
L
E
R
V
A
E
T
L
L
E
R
E
T
L
T
A
E
E
F
Q
R
V
V
E
----------------------------
12
PsiBlast_PDB
72.90
72%
-109
- C2 -
-
1IY1
1
FTSH_THET8
A:
[12-252]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
T
F
K
D
V
A
G
A
E
E
A
K
E
E
L
K
E
I
V
E
F
-
L
K
N
P
S
R
F
H
E
M
G
A
R
I
P
K
G
V
L
L
V
G
P
P
G
V
G
K
T
H
L
A
R
A
V
A
G
E
A
R
V
P
F
I
T
A
S
G
S
D
F
V
E
M
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
R
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
R
---------
N
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
E
K
-
D
T
A
I
V
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
I
A
I
D
A
P
D
V
K
G
R
E
Q
I
L
R
I
H
A
R
G
K
P
L
A
E
D
V
D
L
--
A
L
L
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
L
N
E
A
A
L
L
A
A
R
E
G
R
R
K
I
T
M
K
D
L
E
E
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
70.19
72%
-107
- C2 -
-
1IY0
1
FTSH_THET8
A:
[12-252]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
T
F
K
D
V
A
G
A
E
E
A
K
E
E
L
K
E
I
V
E
F
-
L
K
N
P
S
R
F
H
E
M
G
A
R
I
P
K
G
V
L
L
V
G
P
P
G
V
G
K
T
H
L
A
R
A
V
A
G
E
A
R
V
P
F
I
T
A
S
G
S
D
F
V
E
M
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
R
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
R
K
R
-------
N
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
E
K
-
D
T
A
I
V
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
I
A
I
D
A
P
D
V
K
G
R
E
Q
I
L
R
I
H
A
R
G
K
P
L
A
E
D
V
D
L
--
A
L
L
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
L
N
E
A
A
L
L
A
A
R
E
G
R
R
K
I
T
M
K
D
L
E
E
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
62.14
64%
-52
- C2 -
-
2R65
1
FTSH_HELPY
D:
[2-259]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
A
E
K
P
N
V
R
F
K
D
M
A
G
N
E
E
A
K
E
E
V
V
E
I
V
D
F
-
L
K
Y
P
E
R
Y
A
N
L
G
A
K
I
P
K
G
V
L
L
V
G
P
P
G
T
G
K
T
L
L
A
K
A
V
A
G
E
A
H
V
P
F
F
S
M
G
G
S
S
F
I
E
M
F
V
G
L
G
A
S
R
V
R
D
L
F
E
T
A
K
K
Q
A
P
S
I
I
F
I
D
E
I
D
A
I
G
K
---------
N
D
E
R
E
Q
T
L
N
Q
L
L
A
E
M
D
G
F
G
S
E
N
A
P
V
I
V
L
A
A
T
N
R
P
E
I
L
D
P
A
L
M
R
P
G
R
F
D
R
Q
V
L
V
D
K
P
D
F
N
G
R
V
E
I
L
K
V
H
I
K
G
V
K
L
A
N
D
V
N
L
--
Q
E
V
A
K
L
T
A
G
L
A
G
A
D
L
A
N
I
I
N
E
A
A
L
L
A
G
R
N
N
Q
K
E
V
R
Q
Q
H
L
K
E
A
V
E
R
G
I
A
G
L
E
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
59.31
51%
-94
- C2 -
-
2QZ4
1
A:
[3-256]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
F
K
D
V
A
G
M
H
E
A
K
L
E
V
R
E
F
V
D
Y
-
L
K
S
P
E
------
A
K
V
P
K
G
A
L
L
L
G
P
P
G
C
G
K
T
L
L
A
K
A
V
A
T
E
A
Q
V
P
F
L
A
M
A
G
A
E
F
V
E
V
I
G
G
L
G
A
A
R
V
R
S
L
F
K
E
A
R
A
R
A
P
C
I
V
Y
I
D
E
I
------------------
E
Q
T
L
N
Q
L
L
V
E
M
D
G
M
G
T
-
T
D
H
V
I
V
L
A
S
T
N
R
A
D
I
L
D
G
A
L
M
R
P
G
R
L
D
R
H
V
F
I
D
L
P
T
L
Q
E
R
R
E
I
F
E
Q
H
L
K
S
L
K
L
T
Q
S
S
T
F
Y
S
Q
R
L
A
E
L
T
P
G
F
S
G
A
D
I
A
N
I
C
N
E
A
A
L
H
--------
V
H
T
L
N
F
E
Y
A
V
E
R
V
L
A
G
T
A
K
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
58.96
64%
-55
- C2 -
-
2R65
1
FTSH_HELPY
A:
[2-259]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
A
E
K
P
N
V
R
F
K
D
M
A
G
N
E
E
A
K
E
E
V
V
E
I
V
D
F
-
L
K
Y
P
E
R
Y
A
N
L
G
A
K
I
P
K
G
V
L
L
V
G
P
P
G
T
G
K
T
L
L
A
K
A
V
A
G
E
A
H
V
P
F
F
S
M
G
G
S
S
F
I
E
M
F
V
G
L
G
A
S
R
V
R
D
L
F
E
T
A
K
K
Q
A
P
S
I
I
F
I
D
E
I
D
A
I
G
K
---------
N
D
E
R
E
Q
T
L
N
Q
L
L
A
E
M
D
G
F
G
S
E
N
A
P
V
I
V
L
A
A
T
N
R
P
E
I
L
D
P
A
L
M
R
P
G
R
F
D
R
Q
V
L
V
D
K
P
D
F
N
G
R
V
E
I
L
K
V
H
I
K
G
V
K
L
A
N
D
V
N
L
--
Q
E
V
A
K
L
T
A
G
L
A
G
A
D
L
A
N
I
I
N
E
A
A
L
L
A
G
R
N
N
Q
K
E
V
R
Q
Q
H
L
K
E
A
V
E
R
G
I
A
G
L
E
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
57.64
64%
-45
- C2 -
-
2R65
1
FTSH_HELPY
E:
[2-259]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
A
E
K
P
N
V
R
F
K
D
M
A
G
N
E
E
A
K
E
E
V
V
E
I
V
D
F
-
L
K
Y
P
E
R
Y
A
N
L
G
A
K
I
P
K
G
V
L
L
V
G
P
P
G
T
G
K
T
L
L
A
K
A
V
A
G
E
A
H
V
P
F
F
S
M
G
G
S
S
F
I
E
M
F
V
G
L
G
A
S
R
V
R
D
L
F
E
T
A
K
K
Q
A
P
S
I
I
F
I
D
E
I
D
A
I
G
K
---------
N
D
E
R
E
Q
T
L
N
Q
L
L
A
E
M
D
G
F
G
S
E
N
A
P
V
I
V
L
A
A
T
N
R
P
E
I
L
D
P
A
L
M
R
P
G
R
F
D
R
Q
V
L
V
D
K
P
D
F
N
G
R
V
E
I
L
K
V
H
I
K
G
V
K
L
A
N
D
V
N
L
--
Q
E
V
A
K
L
T
A
G
L
A
G
A
D
L
A
N
I
I
N
E
A
A
L
L
A
G
R
N
N
Q
K
E
V
R
Q
Q
H
L
K
E
A
V
E
R
G
I
A
G
L
E
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
57.14
64%
-46
- C2 -
-
2R65
1
FTSH_HELPY
B:
[2-259]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
A
E
K
P
N
V
R
F
K
D
M
A
G
N
E
E
A
K
E
E
V
V
E
I
V
D
F
-
L
K
Y
P
E
R
Y
A
N
L
G
A
K
I
P
K
G
V
L
L
V
G
P
P
G
T
G
K
T
L
L
A
K
A
V
A
G
E
A
H
V
P
F
F
S
M
G
G
S
S
F
I
E
M
F
V
G
L
G
A
S
R
V
R
D
L
F
E
T
A
K
K
Q
A
P
S
I
I
F
I
D
E
I
D
A
I
G
K
---------
N
D
E
R
E
Q
T
L
N
Q
L
L
A
E
M
D
G
F
G
S
E
N
A
P
V
I
V
L
A
A
T
N
R
P
E
I
L
D
P
A
L
M
R
P
G
R
F
D
R
Q
V
L
V
D
K
P
D
F
N
G
R
V
E
I
L
K
V
H
I
K
G
V
K
L
A
N
D
V
N
L
--
Q
E
V
A
K
L
T
A
G
L
A
G
A
D
L
A
N
I
I
N
E
A
A
L
L
A
G
R
N
N
Q
K
E
V
R
Q
Q
H
L
K
E
A
V
E
R
G
I
A
G
L
E
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
56.53
64%
-36
- C2 -
-
2R65
1
FTSH_HELPY
C:
[2-259]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
A
E
K
P
N
V
R
F
K
D
M
A
G
N
E
E
A
K
E
E
V
V
E
I
V
D
F
-
L
K
Y
P
E
R
Y
A
N
L
G
A
K
I
P
K
G
V
L
L
V
G
P
P
G
T
G
K
T
L
L
A
K
A
V
A
G
E
A
H
V
P
F
F
S
M
G
G
S
S
F
I
E
M
F
V
G
L
G
A
S
R
V
R
D
L
F
E
T
A
K
K
Q
A
P
S
I
I
F
I
D
E
I
D
A
I
G
K
---------
N
D
E
R
E
Q
T
L
N
Q
L
L
A
E
M
D
G
F
G
S
E
N
A
P
V
I
V
L
A
A
T
N
R
P
E
I
L
D
P
A
L
M
R
P
G
R
F
D
R
Q
V
L
V
D
K
P
D
F
N
G
R
V
E
I
L
K
V
H
I
K
G
V
K
L
A
N
D
V
N
L
--
Q
E
V
A
K
L
T
A
G
L
A
G
A
D
L
A
N
I
I
N
E
A
A
L
L
A
G
R
N
N
Q
K
E
V
R
Q
Q
H
L
K
E
A
V
E
R
G
I
A
G
L
E
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
55.20
46%
7
- C2 -
-
3HU3
2
TERA_HUMAN
B:
[200-434]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
G
Y
D
D
I
G
G
C
R
K
Q
L
A
Q
I
K
E
M
V
E
L
P
L
R
H
P
A
L
F
K
A
I
G
V
K
P
P
R
G
I
L
L
Y
G
P
P
G
T
G
K
T
L
I
A
R
A
V
A
N
E
T
G
A
F
F
F
L
I
N
G
P
E
I
M
S
K
L
A
G
E
S
E
S
N
L
R
K
A
F
E
E
A
E
K
N
A
P
A
I
I
F
I
D
E
L
D
A
I
A
P
K
R
E
K
T
H
G
---
E
V
E
R
R
I
V
S
Q
L
L
T
L
M
D
G
L
K
Q
-
R
A
H
V
I
V
M
A
A
T
N
R
P
N
S
I
D
P
A
L
R
R
F
G
R
F
D
R
E
V
D
I
G
I
P
D
A
T
G
R
L
E
I
L
Q
I
H
T
K
N
M
K
L
A
D
D
V
D
L
--
E
Q
V
A
N
E
T
H
G
H
V
G
A
D
L
A
A
L
C
S
E
A
A
L
Q
A
I
R
K
K
M
D
L
I
D
L
E
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
55.13
46%
8
- C2 -
-
4KO8
1
TERA_HUMAN
A:
[200-434]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
G
Y
D
D
I
G
G
C
R
K
Q
L
A
Q
I
K
E
M
V
E
L
P
L
R
H
P
A
L
F
K
A
I
G
V
K
P
P
R
G
I
L
L
Y
G
P
P
G
T
G
K
T
L
I
A
R
A
V
A
N
E
T
G
A
F
F
F
L
I
N
G
P
E
I
M
S
K
L
A
G
E
S
E
S
N
L
R
K
A
F
E
E
A
E
K
N
A
P
A
I
I
F
I
D
E
L
D
A
I
A
P
K
R
E
K
T
H
G
---
E
V
E
R
R
I
V
S
Q
L
L
T
L
M
D
G
L
K
Q
-
R
A
H
V
I
V
M
A
A
T
N
R
P
N
S
I
D
P
A
L
R
R
F
G
R
F
D
R
E
V
D
I
G
I
P
D
A
T
G
R
L
E
I
L
Q
I
H
T
K
N
M
K
L
A
D
D
V
D
L
--
E
Q
V
A
N
E
T
H
G
H
V
G
A
D
L
A
A
L
C
S
E
A
A
L
Q
A
I
R
K
K
M
D
L
I
D
L
E
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
55.12
46%
9
- C2 -
-
4KO8
2
TERA_HUMAN
B:
[200-434]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
G
Y
D
D
I
G
G
C
R
K
Q
L
A
Q
I
K
E
M
V
E
L
P
L
R
H
P
A
L
F
K
A
I
G
V
K
P
P
R
G
I
L
L
Y
G
P
P
G
T
G
K
T
L
I
A
R
A
V
A
N
E
T
G
A
F
F
F
L
I
N
G
P
E
I
M
S
K
L
A
G
E
S
E
S
N
L
R
K
A
F
E
E
A
E
K
N
A
P
A
I
I
F
I
D
E
L
D
A
I
A
P
K
R
E
K
T
H
G
---
E
V
E
R
R
I
V
S
Q
L
L
T
L
M
D
G
L
K
Q
-
R
A
H
V
I
V
M
A
A
T
N
R
P
N
S
I
D
P
A
L
R
R
F
G
R
F
D
R
E
V
D
I
G
I
P
D
A
T
G
R
L
E
I
L
Q
I
H
T
K
N
M
K
L
A
D
D
V
D
L
--
E
Q
V
A
N
E
T
H
G
H
V
G
A
D
L
A
A
L
C
S
E
A
A
L
Q
A
I
R
K
K
M
D
L
I
D
L
E
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
55.07
46%
6
- C2 -
-
3HU3
1
TERA_HUMAN
A:
[200-434]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
G
Y
D
D
I
G
G
C
R
K
Q
L
A
Q
I
K
E
M
V
E
L
P
L
R
H
P
A
L
F
K
A
I
G
V
K
P
P
R
G
I
L
L
Y
G
P
P
G
T
G
K
T
L
I
A
R
A
V
A
N
E
T
G
A
F
F
F
L
I
N
G
P
E
I
M
S
K
L
A
G
E
S
E
S
N
L
R
K
A
F
E
E
A
E
K
N
A
P
A
I
I
F
I
D
E
L
D
A
I
A
P
K
R
E
K
T
H
G
---
E
V
E
R
R
I
V
S
Q
L
L
T
L
M
D
G
L
K
Q
-
R
A
H
V
I
V
M
A
A
T
N
R
P
N
S
I
D
P
A
L
R
R
F
G
R
F
D
R
E
V
D
I
G
I
P
D
A
T
G
R
L
E
I
L
Q
I
H
T
K
N
M
K
L
A
D
D
V
D
L
--
E
Q
V
A
N
E
T
H
G
H
V
G
A
D
L
A
A
L
C
S
E
A
A
L
Q
A
I
R
K
K
M
D
L
I
D
L
E
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
54.77
49%
12
- C2 -
-
3H4M
1
PAN_METJA
B:
[5-259]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
M
E
V
D
-
E
R
P
N
V
R
Y
E
D
I
G
G
L
E
K
Q
M
Q
E
I
R
E
V
V
E
L
P
L
K
H
P
E
L
F
E
K
V
G
I
E
P
P
K
G
I
L
L
Y
G
P
P
G
T
G
K
T
L
L
A
K
A
V
A
T
E
T
N
A
T
F
I
R
V
V
G
S
E
L
V
K
K
F
I
G
E
G
A
S
L
V
K
D
I
F
K
L
A
K
E
K
A
P
S
I
I
F
I
D
E
I
D
A
I
A
A
K
R
T
D
A
L
T
G
G
D
R
E
V
Q
R
T
L
M
Q
L
L
A
E
M
D
G
F
D
A
-
R
G
D
V
K
I
I
G
A
T
N
R
P
D
I
L
D
P
A
I
L
R
P
G
R
F
D
R
I
I
E
V
P
A
P
D
E
K
G
R
L
E
I
L
K
I
H
T
R
K
M
N
L
A
E
D
V
N
L
--
E
E
I
A
K
M
T
E
G
C
V
G
A
E
L
K
A
I
C
T
E
A
G
M
N
A
I
R
E
L
R
D
Y
V
T
M
D
D
F
R
K
A
V
E
K
I
M
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
54.49
49%
14
- C2 -
-
3H4M
1
PAN_METJA
A:
[5-259]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
M
E
V
D
-
E
R
P
N
V
R
Y
E
D
I
G
G
L
E
K
Q
M
Q
E
I
R
E
V
V
E
L
P
L
K
H
P
E
L
F
E
K
V
G
I
E
P
P
K
G
I
L
L
Y
G
P
P
G
T
G
K
T
L
L
A
K
A
V
A
T
E
T
N
A
T
F
I
R
V
V
G
S
E
L
V
K
K
F
I
G
E
G
A
S
L
V
K
D
I
F
K
L
A
K
E
K
A
P
S
I
I
F
I
D
E
I
D
A
I
A
A
K
R
T
D
A
L
T
G
G
D
R
E
V
Q
R
T
L
M
Q
L
L
A
E
M
D
G
F
D
A
-
R
G
D
V
K
I
I
G
A
T
N
R
P
D
I
L
D
P
A
I
L
R
P
G
R
F
D
R
I
I
E
V
P
A
P
D
E
K
G
R
L
E
I
L
K
I
H
T
R
K
M
N
L
A
E
D
V
N
L
--
E
E
I
A
K
M
T
E
G
C
V
G
A
E
L
K
A
I
C
T
E
A
G
M
N
A
I
R
E
L
R
D
Y
V
T
M
D
D
F
R
K
A
V
E
K
I
M
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
52.68
48%
23
- C2 -
-
5EQT
1
PAN_PYRHO
A:
[2-251]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
Y
N
D
I
G
G
L
K
K
Q
L
Q
E
L
R
E
A
I
E
L
P
L
K
H
P
E
L
F
E
E
V
G
I
D
P
P
K
G
V
L
L
Y
G
P
P
G
C
G
K
T
L
M
A
K
A
L
A
H
E
V
N
A
T
F
I
R
V
V
G
S
E
L
V
R
K
Y
I
G
E
G
A
R
L
V
H
E
L
F
E
L
A
K
E
K
A
P
T
I
I
F
I
D
E
I
D
A
I
G
A
K
--------
E
R
E
V
N
R
T
L
M
Q
L
L
A
E
M
D
G
F
D
P
-
R
G
N
V
K
V
I
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
L
I
E
V
P
L
P
D
F
E
G
R
L
E
I
L
K
V
H
T
R
R
M
K
L
-
K
G
V
D
L
--
R
A
I
A
E
M
T
E
G
A
S
G
A
D
L
K
A
I
A
T
E
A
G
M
F
A
I
R
E
R
R
T
Y
V
T
Q
E
D
F
L
K
A
V
D
K
V
L
G
N
E
R
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
52.24
49%
24
- C2 -
-
3H4M
1
PAN_METJA
C:
[5-259]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
M
E
V
D
-
E
R
P
N
V
R
Y
E
D
I
G
G
L
E
K
Q
M
Q
E
I
R
E
V
V
E
L
P
L
K
H
P
E
L
F
E
K
V
G
I
E
P
P
K
G
I
L
L
Y
G
P
P
G
T
G
K
T
L
L
A
K
A
V
A
T
E
T
N
A
T
F
I
R
V
V
G
S
E
L
V
K
K
F
I
G
E
G
A
S
L
V
K
D
I
F
K
L
A
K
E
K
A
P
S
I
I
F
I
D
E
I
D
A
I
A
A
K
R
T
D
A
L
T
G
G
D
R
E
V
Q
R
T
L
M
Q
L
L
A
E
M
D
G
F
D
A
-
R
G
D
V
K
I
I
G
A
T
N
R
P
D
I
L
D
P
A
I
L
R
P
G
R
F
D
R
I
I
E
V
P
A
P
D
E
K
G
R
L
E
I
L
K
I
H
T
R
K
M
N
L
A
E
D
V
N
L
--
E
E
I
A
K
M
T
E
G
C
V
G
A
E
L
K
A
I
C
T
E
A
G
M
N
A
I
R
E
L
R
D
Y
V
T
M
D
D
F
R
K
A
V
E
K
I
M
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
102
PsiBlast_CBE
47.40
47%
3
- C2 -
-
1E32
1
TERA_MOUSE
A:
[200-434]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
G
Y
D
D
V
G
G
C
R
K
Q
L
A
Q
I
K
E
M
V
E
L
P
L
R
H
P
A
L
F
K
A
I
G
V
K
P
P
R
G
I
L
L
Y
G
P
P
G
T
G
K
T
L
I
A
R
A
V
A
N
E
T
G
A
F
F
F
L
I
N
G
P
E
I
M
S
K
L
A
G
E
S
E
S
N
L
R
K
A
F
E
E
A
E
K
N
A
P
A
I
I
F
I
D
E
L
D
A
I
A
P
K
R
E
K
T
H
G
---
E
V
E
R
R
I
V
S
Q
L
L
T
L
M
D
G
L
K
Q
-
R
A
H
V
I
V
M
A
A
T
N
R
P
N
S
I
D
P
A
L
R
R
F
G
R
F
D
R
E
V
D
I
G
I
P
D
A
T
G
R
L
E
I
L
Q
I
H
T
K
N
M
K
L
A
D
D
V
D
L
--
E
Q
V
A
N
E
T
H
G
H
V
G
A
D
L
A
A
L
C
S
E
A
A
L
Q
A
I
R
K
K
M
D
L
I
D
L
E
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
47.19
47%
1
- C2 -
-
1R7R
1
TERA_MOUSE
A:
[200-468]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
G
Y
D
D
V
G
G
C
R
K
Q
L
A
Q
I
K
E
M
V
E
L
P
L
R
H
P
A
L
F
K
A
I
G
V
K
P
P
R
G
I
L
L
Y
G
P
P
G
T
G
K
T
L
I
A
R
A
V
A
N
E
T
G
A
F
F
F
L
I
N
G
P
E
I
M
S
K
L
A
G
E
S
E
S
N
L
R
K
A
F
E
E
A
E
K
N
A
P
A
I
I
F
I
D
E
L
D
A
I
A
P
K
R
E
K
T
H
G
---
E
V
E
R
R
I
V
S
Q
L
L
T
L
M
D
G
L
K
---
A
H
V
I
V
M
A
A
T
N
R
P
N
S
I
D
P
A
L
R
R
F
G
R
F
D
R
E
V
D
I
G
I
P
D
A
T
G
R
L
E
I
L
Q
I
H
T
K
N
M
K
L
A
D
D
V
D
L
--
E
Q
V
A
N
E
T
H
G
H
V
G
A
D
L
A
A
L
C
S
E
A
A
L
Q
A
I
R
K
K
M
D
L
I
D
L
E
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
114
Fugue
46.41
31%
-13
- C2 -
-
1E32
1
TERA_MOUSE
A:
[21-458]
--
N
R
P
N
R
L
I
V
D
E
A
I
N
E
D
N
S
V
V
S
L
S
Q
P
K
M
D
E
L
Q
L
F
R
G
D
T
V
L
L
K
G
K
K
R
R
E
A
V
C
I
V
L
S
D
D
---
T
C
S
D
E
K
I
R
M
N
R
V
V
R
N
N
L
R
V
R
L
G
D
V
I
S
I
Q
P
C
P
D
V
K
Y
G
K
-
R
I
H
V
L
P
I
D
D
T
V
E
G
I
T
G
N
L
F
E
V
Y
L
K
P
Y
F
L
E
A
Y
R
P
I
R
K
G
D
I
F
L
V
R
G
G
M
R
A
V
E
F
K
V
V
E
T
D
P
S
P
Y
C
I
VAP
D
T
V
I
H
C
E
G
E
P
I
K
R
E
D
E
E
E
S
L
N
E
V
G
Y
D
D
V
G
G
C
R
K
Q
L
A
Q
I
K
E
M
V
E
L
P
L
R
H
P
A
L
F
K
A
I
G
V
K
P
P
R
G
I
L
L
Y
G
P
P
G
T
G
K
T
L
I
A
R
A
V
A
N
E
T
G
A
F
F
F
L
I
N
G
P
E
I
M
S
K
L
A
G
E
S
E
S
N
L
R
K
A
F
E
E
A
E
K
N
A
P
A
I
I
F
I
D
E
L
D
A
I
A
P
K
R
E
K
T
---
H
G
E
V
E
R
R
I
V
S
Q
L
L
T
L
M
D
G
L
K
Q
-
R
A
H
V
I
V
M
A
A
T
N
R
P
N
S
I
D
P
A
L
R
R
F
G
R
F
D
R
E
V
D
I
G
I
P
D
A
T
G
R
L
E
I
L
Q
I
H
T
K
N
M
K
L
A
D
D
V
D
L
--
E
Q
V
A
N
E
T
H
G
H
V
G
A
D
L
A
A
L
C
S
E
A
A
L
Q
A
I
R
K
K
M
D
L
I
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
D
E
T
I
D
A
E
V
M
N
S
L
A
V
T
M
D
D
F
R
W
A
L
S
Q
------------------------------------------